ライフサイエンスコーパス: suboptimal

1 ed for infectious use, 21.0% were considered suboptimal.

2 lthough early detection and surveillance are suboptimal.

3 bute to protection if antibody responses are suboptimal.

4 However, the quality of the trials is suboptimal.

5 from spring assisted cranioplasty may remain suboptimal.

6 men (MSM) in China, yet HIV testing remains suboptimal.

7 atients with heart disease, its use has been suboptimal.

8 Outcomes with medical therapy remain suboptimal.

9 he overall average treatment effect could be suboptimal.

10 the diagnosis of HRS-1 and guide therapy are suboptimal.

11 ementation of delirium guidelines at ICUs is suboptimal.

12 ty between two gene networks, and it is thus suboptimal.

13 comes using oral antifungal triazoles remain suboptimal.

14 hat the reporting quality of such trials was suboptimal.

15 that personal protective equipment (PPE) was suboptimal.

16 eutic efficacy of these technologies remains suboptimal.

17 ated life-threatening cardiac events remains suboptimal.

18 ments of multiple myeloma disease burden are suboptimal.

19 are unknown and therapy success rates remain suboptimal.

20 ents and clinicians are infrequent and often suboptimal.

21 ty, immigrant, or rural populations who have suboptimal access to quality oral health care.

22 99DOTS had suboptimal accuracy for measuring adherence, partly due

23 )B(-) severe combined immunodeficiency), its suboptimal activity is associated with a broad spectrum

24 For individuals showing suboptimal adaptations to resistance training, manipulat

25 Suboptimal adherence and persistence to DOACs was common

26 adult care, but unsuppressed viral load and suboptimal adherence are a concern.

27 In addition, suboptimal adherence to oral daily regimens can negative

28 nal support may be protective; (c) Adherence-suboptimal adherence was associated with older age, barr

29 Sparse, heterogeneous data with suboptimal adjustment for potential confounders.

30 ces, and the selected aptamers often exhibit suboptimal affinity and specificity.

31 graft function (DGF), however, often have a suboptimal allograft milieu, which may alter the risk/be

32 global Abeta burden; however, sensitivity is suboptimal and can lead to low power in clinical trials.

33 This is attributed in part to the suboptimal and short-lived immunity elicited by acellula

34 to solve this task the circuit has adopted a suboptimal and task-specific computation that discards i

35 We conclude that existing tools are suboptimal and that improvements, if they can be made, w

36 nt PrEP coverage in this cohort of YBMSM was suboptimal, and discontinuations were common despite add

37 rsisted to trial completion even when it was suboptimal, and were more likely to complete the trial t

38 in many patients with cancer receiving no or suboptimal anemia therapy.

39 This study shows that suboptimal anti-A3G activity shapes viral fitness and dr

40 Taken together, HIV variants with suboptimal anti-A3G activity were attenuated in the abse

41 d CD8 T cells, potentially contributing to a suboptimal anti-HIV immune response within the lungs.

42 eved reductions in overall, unnecessary, and suboptimal antibiotic prescription rates, which were sus

43 eved reductions in overall, unnecessary, and suboptimal antibiotic prescription rates, which were sus

44 Predictors of suboptimal antibiotic treatment included: prior fluoroqu

45 Predictors of suboptimal antibiotic treatment should be targeted with

46 Potentially suboptimal antibiotic treatment was identified in 65.0%

47 ntify resident characteristics predictive of suboptimal antibiotic treatment, using multivariable unc

48 r infectious use, 25.9% were prescribed >= 1 suboptimal antibiotic.

49 ctivation and increased apoptosis leading to suboptimal antibody responses against common infectious

50 that food insecurity may be associated with suboptimal ART adherence and/or drug absorption.

51 Compounding the problem, outcomes remain suboptimal because of a lack of awareness and a severe p

52 s at the expense of hepatocyte injury and is suboptimal because of lower expression of thyroid hormon

53 Unfortunately, current treatments of AF are suboptimal because they are not targeted to the molecula

54 t the lower contrast-to-noise ratio of BOLD, suboptimal behavioural performance, and motion artefacts

55 ased integration noise, displayed a range of suboptimal behaviours: they ignored stimulus base rates,

56 Our results support suboptimal biological sampling as a contributor to false

57 ceptible to ecological traps by returning to suboptimal breeding habitats that were dramatically alte

58 tools for prostate cancer (PC) prognosis are suboptimal but may be improved by better knowledge about

59 ted that human perceptual decision making is suboptimal but the nature and origins of this suboptimal

60 regional lymphatics and who were considered suboptimal candidates for conventional RT were eligible.

61 ore broadly since genomic analysis indicates suboptimal canonical miRNAs are enriched in operons, and

62 re produced with delayed kinetics and induce suboptimal CD8(+) T cell responses.

63 lp maintain protein-folding homeostasis in a suboptimal cellular folding environment.

64 echniques are based on Euclidean geometry, a suboptimal choice for modeling complex cell trajectories

65 istinct reward representations confirms that suboptimal choice for temporally extended outcomes can b

66 mbers individually have information favoring suboptimal choices but the group collectively has inform

67 y when an environment becomes worse leads to suboptimal choices: options that are valuable given the

68 ysiological reserve and a key contributor to suboptimal clinical outcomes in various lung disease gro

69 extent translational selection drives use of suboptimal codons or codon pairs.

70 omputationally grounded explanation of human suboptimal cognitive inference.

71 isonii in its historic mangrove habitat, the suboptimal colonized salt marsh ecosystem, and on docks

72 impacts of internal noise and deterministic suboptimal computations.

73 y: stimulus variability, internal noise, and suboptimal computations.

74 o permits isolation of the direct effects of suboptimal conditions during development on the cardiac

75 ng too much or too little fuel would lead to suboptimal conditions for development.

76 not previously inhabited, it may experience suboptimal conditions that challenge its continued persi

77 However, during suboptimal conditions, urban stork diet expanded to incl

78 in increased reproductive performance during suboptimal conditions.

79 y having the genetic capability to withstand suboptimal conditions.

80 mmon abnormal behaviours that often arise in suboptimal conditions.

81 and fetal death, but findings are limited by suboptimal control of biases.

82 ose studies are difficult to compare, due to suboptimal control populations and wide variations in fo

83 Suboptimal coverage markedly reduced DALYs averted and c

84 kers encode overall value more strongly, and suboptimal decision-makers encode the disincentive markd

85 can separate efficient decision-makers from suboptimal decision-makers.

86 o support viewing rationalization as a quite suboptimal defense mechanism.

87 d for infectious use that were classified as suboptimal, defined as inappropriate or needing modifica

88 ffects and low effectiveness associated with suboptimal delivery systems have impeded their use in tr

89 vation in SHIV(SF162P3)-infected RMs despite suboptimal depletion of CD8(+) T cells and profound ART-

90 Fluconazole monotherapy was suboptimal despite Cryptococcus-negative CSF.

91 .992), but the immune gene sets demonstrated suboptimal diagnostic performance (AUC <= 0.720).

92 immunodeficiency virus (HIV) globally, with suboptimal diagnostics and management contributing to hi

93 ler of people living with HIV globally, with suboptimal diagnostics and management contributing to hi

94 and type 2 diabetes that was associated with suboptimal dietary quality was 62.2% in 1982, 57.9% in 1

95 highlighting the vulnerability conferred by suboptimal disease control.

96 Coordination also remains suboptimal, documented by multiple governmental reports

97 ion (NMP) can be used to assess viability of suboptimal donor livers before implantation.

98 dopamine-enhancing drugs, whereas those with suboptimal dopaminergic signaling would benefit and exhi

99 Furthermore, suboptimal dose administration of DNTs in highly aggress

100 choice was identified in 45.6% of residents, suboptimal dose frequency in 28.6%, and longer than reco

101 LV.InsB in combination with a suboptimal dose of anti-CD3 monoclonal antibody (combine

102 od clinical response, and one who received a suboptimal dose of letermovir experienced an increase of

103 Our results stress the need to evaluate suboptimal dosing for any new RSV vaccine candidate deve

104 However, current therapies are suboptimal due to adverse effects.

105 CLL, residual disease, acquired resistance, suboptimal durability of response in patients with high-

106 including prasugrel or ticagrelor, provides suboptimal early inhibition of platelet aggregation (IPA

107 System challenges include: the suboptimal education and training of primary health-care

108 , and current seasonal influenza vaccine has suboptimal effectiveness.

109 ically tested anti-CTLA-4 antibodies exhibit suboptimal efficacy but high toxicity.

110 Rotavirus vaccines have suboptimal efficacy in low- to middle-income countries,

111 Putative mechanisms of suboptimal efficacy of DARA include downregulation of CD

112 ibuting to the poor clinical outcomes is the suboptimal efficacy of standard therapies due to dose li

113 inhibit FAAH activity which may have led to suboptimal efficacy.

114 uch biohybrid systems are often plagued with suboptimal electrodes, which limits the incorporation an

115 ediction but also challenges when there is a suboptimal evidence base for the clinical consequences o

116 rgy CT colonography phantom, especially with suboptimal fecal tagging.

117 and quality creates an increasing period of suboptimal feeding conditions for zooplankton at a time

118 pregnancy prevention measures and addressing suboptimal feeding practices are beneficial to mitigate

119 infants whose birth weights did not indicate suboptimal fetal growth.

120 nd practice in patients with aortic VHD, the suboptimal figure in mitral VHD and late referral for va

121 The phantom's complexity led to suboptimal filling, particularly of the hot rod section,

122 unctional assays on neuronal cultures (i.e., suboptimal fluorescence signals, phototoxicity, and unph

123 tibiotic use, excess antibiotic duration, or suboptimal fluoroquinolone use.

124 ues, indicating that the Rcr3 co-receptor is suboptimal for Avr2 binding.

125 Scoring systems are suboptimal for determining risk in patients with upper g

126 Survival remains suboptimal for intermediate-risk and high-risk patients

127 Metronidazole is suboptimal for nonsevere CDI as it is less beneficial th

128 nt conditions in the Salish Sea are actually suboptimal for Olympia oyster larvae from populations in

129 tive and false-positive rates makes the test suboptimal for prevaccination screening.

130 ple size studies and case-control models are suboptimal for tackling heterogeneity.

131 cific antibodies (DSA), but its mechanism is suboptimal for the inhibition of alloimmunity in that CT

132 compared to rodents, rendering this approach suboptimal for treatment of the global brain lesions pre

133 ns, the predictive accuracy of the former is suboptimal for use in clinical practice.

134 e, we present evidence that psMEK indeed has suboptimal functionality in vivo and propose a strategy

135 Accordingly, suboptimal GC responses in ATM-deficient animals are cha

136 >2 hours duration) compared to studies with suboptimal GE test methods.

137 basis of medically attended case numbers is suboptimal given its reliance on testing strategy, chang

138 risk of hypoglycemia and are associated with suboptimal glycemic control outcomes.

139 ealth in adult life may occur partly through suboptimal growth and development, as suggested by epide

140 The basis for suboptimal growth is the imbalanced metabolism that is r

141 ctose induction requires cell cultivation in suboptimal growth media, which is tedious especially whe

142 However, the suboptimal growth of CVVs in mammalian cells and chicken

143 e southern edge of their distribution due to suboptimal habitat conditions.

144 season, pelican cohorts began by foraging in suboptimal habitats relative to the availability of high

145 Proximity-based enhancement of suboptimal hairpin processing provides a rationale for g

146 on-premises continuous safe water supplies, suboptimal household water storage practices are likely

147 Many patients have suboptimal iliofemoral access options or reasons why ear

148 nfidence interval: 1.01 to 1.59) and poor or suboptimal image quality (odds ratio: 4.93; 95% confiden

149 TEE, with longer procedural time and poor or suboptimal image quality determining an increased risk.

150 l; quality was considered optimal in 89% and suboptimal in 11%.

151 tion through the WDD, and IL-10 signaling is suboptimal in cells lacking the WDD owing to delayed end

152 Current blood biomarkers are suboptimal in detecting drug-induced liver injury (DILI)

153 However, immune checkpoint blockade is still suboptimal in HCC treatment and more immune modification

154 act through common end-effectors and may be suboptimal in patients with comorbidities.

155 However, GE test methods were suboptimal in some studies.

156 iagnostic accuracy of the CryptoPS assay was suboptimal in the context of CrAg screening, with poor s

157 uired pneumonia (HAP) classifications may be suboptimal in this context and merits strict academic sc

158 uman brain development is rudimentary due to suboptimal in vitro and animal models.

159 Besides waning of antibody responses, suboptimal induction of T-cell responses may reduce prot

160 ism transmission of resistance determinants, suboptimal infection prevention practices and increasing

161 Unexpectedly, we found that TLR9L induced a suboptimal inflammatory milieu and promoted the antigen-

162 Recurrent reports of suboptimal influenza vaccine effectiveness have renewed

163 Potentially suboptimal initial drug choice was identified in 45.6% o

164 ive risk assessment, in which the effects of suboptimal intakes of 12 dietary factors, individually a

165 ends on the slow reorganization of many weak suboptimal interactions within the mRNA.

166 ormance throughout the detector array due to suboptimal intercrystal light sharing.

167 mited to oncology indications based on their suboptimal kinase selectivity.

168 2.03); RIF, PZA, and LZD showed moderate yet suboptimal lesion penetration (median RPL 0.61, range 0.

169 al drugs, causing therapeutics to reach only suboptimal level to the brain.

170 hotosynthetic competence, particularly under suboptimal light regimes.

171 iction of graft function and modification of suboptimal livers.

172 nsplant has led transplant centers to accept suboptimal livers.

173 s and the ability for strains to escape from suboptimal local fitness maxima.

174 ng memory during optimal (high-attention) or suboptimal (low-attention) moments.

175 of MOUD; however, the uptake of MOUD remains suboptimal (<50%).

176 Despite rising prevalence and incidence, suboptimal management of gout continues in many countrie

177 ffects and/or lack of efficacy can result in suboptimal management of symptoms and, in many cases, si

178 We found suboptimal management practices across 3 management leve

179 A suboptimal maternal diet combined with accelerated postn

180 t only age, high-risk MM, renal disease, and suboptimal MM control remained independent predictors of

181 ion and belief, leading to the production of suboptimal models of the world.

182 ematic threshold determination may result in suboptimal module identification and a large number of u

183 I in cases was considered optimal in 60% and suboptimal (motion artifacts in one or two sequences) in

184 either permanent darkness or light leads to suboptimal muscle growth.

185 3 (ISS3), high-risk disease, renal disease, suboptimal myeloma control (active or progressive diseas

186 inflammasome activation under conditions of suboptimal NAIP/NLRC4 activation, as observed in THP-1 c

187 cal concept embeddings generally suffer from suboptimal NER tools, small-scale evaluation, and limite

188 ions over false beliefs, actually stems from suboptimal neural heuristics over rational beliefs about

189 Degranulation was enhanced upon suboptimal neutrophil activation, whereas production of

190 in cancer treatment has been criticized for suboptimal non-representative inclusion.

191 tively, suggesting that flaviviruses may use suboptimal NS3 helicase activity for optimal genome repl

192 stock and an additional barcoded stock with suboptimal nucleotides corrected (SIVmac239Opt5M).

193 ned to receive triptorelin and letrozole had suboptimal OFS after cycle 1 (six events during 127 meas

194 However, the contacts are suboptimal on both sides.

195 in quality control during the translation of suboptimal open reading frames.

196 ion is an emerging principle that eliminates suboptimal or potentially dangerous cells.

197 Y) SPECT/CT or PET/CT was scored as optimal, suboptimal, or not optimal.

198 s would not have routinely reviewed 46.1% of suboptimal orders.

199 edical problem upon admission, 5 (2%) due to suboptimal organ quality on arrival, and only 4 (1.6%) d

200 significant associations were found between suboptimal outcome and other baseline factors (magnitude

201 articular, integrates information related to suboptimal outcomes from different psychological domains

202 employing each component separately may have suboptimal outcomes.

203 ossible in a field that has been hampered by suboptimal outcomes.

204 mors and has been associated clinically with suboptimal outcomes.

205 of brain network dysfunctions, resulting in suboptimal outcomes.

206 nd its engineered variants for canonical and suboptimal PAMs correlated with previous findings on the

207 histological typing difficult and leading to suboptimal patient care and decisions regarding treatmen

208 d with work dissatisfaction and provision of suboptimal patient care.

209 Suboptimal patient cohort selection and recruiting techn

210 Resource rationality may explain suboptimal patterns of reasoning; but what of "anti-Baye

211 ng chemistry efforts to produce a probe with suboptimal performance when applied in vivo.

212 sh-frozen or similar-type samples, may cause suboptimal performance.

213 alidation of the hospital-onset rule yielded suboptimal performance.

214 atives in this case but they also often show suboptimal performances, especially when signals are wea

215 Except for extremely preterm infants with suboptimal perinatal care or major antenatal events that

216 ltration into and activation within tumours, suboptimal persistence in vivo, antigen escape and heter

217 However, suboptimal photothermal conversion and limited therapeut

218 pic high-throughput screening (HTS) hit with suboptimal physicochemical properties.

219 Suboptimal position was more common in obese patients.

220 suffered from a short in vivo half-life and suboptimal potency in whole blood.

221 ion due to pathogen-contaminated edibles, to suboptimal potency of temperature-sensitive vaccines.

222 k of access to testing and concern regarding suboptimal PPE are common among residency programs.

223 or further improvement, as inappropriate and suboptimal prescribing remained common.

224 r, random distribution of masks is generally suboptimal; prioritized coverage of the elderly improves

225 ts with acute myeloid leukemia (AML) remains suboptimal, prompting the search for additional and syne

226 to overcome the limitations arising from the suboptimal properties of the generic molecular fluoresce

227 ration but to a lesser extent, likely due to suboptimal PTEN mRNA knockdown using this approach.

228 and healthcare provider dissatisfaction, and suboptimal quality of services and retention in care.

229 imitations of this study include the largely suboptimal quality of studies.

230 promise, the poor temperature tolerance and suboptimal quantum yield of the existing metal halide pe

231 ater osteoclast differentiation potential at suboptimal RANK-L concentrations.

232 ironments, older adults rely more heavily on suboptimal reinforcement-learning strategies supported b

233 The ability to stop a suboptimal response is integral to decision making and i

234 with newly diagnosed multiple myeloma and a suboptimal response to immunomodulatory induction therap

235 mercaptopurine (MP) due to adverse events or suboptimal response.

236 fulfilling current guidelines criteria have suboptimal responses following cardiac resynchronization

237 nts has been necessarily empirical, yielding suboptimal results when translated to patients.

238 suggests that this approach likely produces suboptimal results.

239 were associated with lower relative risk of suboptimal retention (N=2,576; LR aRR 0.88, 95% CI 0.87

240 models were 0.69 (95% CI = 0.67 - 0.71) for suboptimal retention and 0.76 (95% CI = 0.72 - 0.79) for

241 re of engagement in HIV care (the Index) and suboptimal retention and viral suppression (VS) outcomes

242 dex scores are significantly associated with suboptimal retention and VS outcomes.

243 tionship between poorer cardiac function and suboptimal retinal microvascular geometry, among Chinese

244 unger and more likely to have likely to have suboptimal risk factor control but had fewer prescriptio

245 Suboptimal S1PR1 angiocrine signaling causes reduced res

246 infection in the United States, in light of suboptimal screening coverage, remains unclear.

247 KE had reduced repeatability because of suboptimal segmentation methods and requires further dev

248 many of the available chemical tools possess suboptimal selectivity and efficacy.

249 ecurity is a well-established determinant of suboptimal, self-reported antiretroviral therapy (ART) a

250 e to the heterogeneous nature of PCa and the suboptimal sensitivity of the techniques themselves.

251 t (Alere Determine TB LAM Ag [AlereLAM]) has suboptimal sensitivity, which restricts its use in clini

252 lead to a mismanagement of byproducts and to suboptimal solutions in terms of regional GHG emissions.

253 iably change IDU prevalence estimates due to suboptimal specificity of data points.

254 event the possibility of a chronic blood CoQ suboptimal status in such groups of patients.

255 airpin with a suboptimal terminal loop and a suboptimal stem length, accumulates to 40-fold higher le

256 Thus, suboptimal stimulation and weak and mostly reversible in

257 w researchers entering the field, leading to suboptimal study designs.

258 10 LPMO, an observation likely indicative of suboptimal substrate binding leading to autocatalytic ox

259 ment and transfer of Microprocessor enhances suboptimal substrate processing.

260 ical trials of various AKT inhibitors remain suboptimal, suggesting that AKT-driven tumor metastasis

261 mice, IFN-gammaR-deficient PLP-CD8 exhibited suboptimal suppression in WT mice.

262 The cumulative probability of a suboptimal surgical outcome by 3 years was 28% (19 of 72

263 The primary outcome was suboptimal surgical outcome by 3 years, defined as const

264 icipants (10%) in the BLRc group (8 of 9 met suboptimal surgical outcome criteria) and in 4 participa

265 rticipants (5%) in the R&R group (3 of 4 met suboptimal surgical outcome criteria; treatment group di

266 Between optimal vs suboptimal surgical outcomes 99 probes displayed signifi

267 in asthma management, and can partly explain suboptimal symptom control.

268 r cause of failed drug discovery programs is suboptimal target selection, resulting in the developmen

269 ial for T cell activation and survival after suboptimal TCR activation, as mice engineered with a T c

270 e identified; shared safety threats included suboptimal technology design, whereas shared resilience

271 at Escherichia coli DeltabipA cells grown at suboptimal temperature accumulate immature large subunit

272 ion of the media with lysine and arginine or suboptimal temperature appears to delay block 3 folding,

273 miR-451, which derives from a hairpin with a suboptimal terminal loop and a suboptimal stem length, a

274 ection against C. rodentium infection due to suboptimal Th17 cell differentiation in vivo.

275 One-quarter of these children are receiving suboptimal therapy, and nearly half of suboptimal use is

276 vere symptoms, with aggregation occurring at suboptimal thrombin concentrations.

277 plantation, are being explored yet have been suboptimal to date.

278 that spatial correlation in risk can make it suboptimal to focus solely on the highest-risk sites, me

279 Methods based on SVR seem to be suboptimal to handle sparse data and yield results compa

280 paradigms that have been used previously are suboptimal to measure the speed of spatiotopic updating.

281 Limiting factors in ACT experiments include suboptimal trafficking to, and poor persistence in, the

282 predictions on average and sometimes yields suboptimal transplant decisions.

283 rience medication fatigue that might lead to suboptimal treatment adherence and the emergence of drug

284 We described the frequency of potentially suboptimal treatment among residents with an incident UT

285 ky blood vessels contribute significantly to suboptimal treatment efficacy.

286 with frequent drug-related side effects and suboptimal treatment outcomes.

287 o findings in non-VA facilities, potentially suboptimal treatment was common but improving in CLC res

288 Residents with UTIs receiving potentially suboptimal treatment were compared to those receiving op

289 Women continue to receive suboptimal treatment, compared with men, with no obvious

290 However, less is known about the extent of suboptimal treatment, in terms of antibiotic choice, dos

291 and metabolic contributions to the disease, suboptimal trial designs, and lack of a clear understand

292 However, enrollment was suboptimal, triggering premature study discontinuation.

293 This off-target uptake can lead to suboptimal tumor-to-background activity concentration ra

294 riven by increased apoptosis, and results in suboptimal up-regulation of T cell-polarizing cytokines

295 iving suboptimal therapy, and nearly half of suboptimal use is not captured by current ASP practices.

296 sk for severe influenza infection because of suboptimal vaccine immunogenicity.

297 iencing measles reemergence as the result of suboptimal vaccine uptake and marked immunity gaps among

298 stically on two competing Tcrb alleles, with suboptimal Vbeta recombination signal sequences limiting

299 e-related impairments in innate immunity and suboptimal virus-specific T cell and antibody responses

300 imize nitrogen (N(2)) fixation, resulting in suboptimal yields.