ライフサイエンスコーパス: substance

1 )-arborisidine, an enantiomer of the natural substance.

2 ation of cannabis as a Schedule 1 controlled substance.

3 nk for many of the over 100 million man-made substances.

4 s challenged by the availability of standard substances.

5 nsors of environmental irritants and noxious substances.

6 plays an important role in identifying spicy substances.

7 ther macromolecule-stabilizing (kosmotropic) substances.

8 l migration limits exist currently for these substances.

9 onstrated on advanced intermediates and drug substances.

10 enable the reduction of the use of hazardous substances.

11 and displays diverse spatial patterns of the substances.

12 r that becomes contaminated with radioactive substances.

13 on of potentially mutagenic and carcinogenic substances.

14 ants are not able to completely remove these substances.

15 being influenced by extracellular polymeric substances.

16 iscated street sample containing two unknown substances.

17 ugh increased regulatory control of chemical substances.

18 n include more than production of vasoactive substances.

19 w detection limits to be reached for all the substances.

20 actors (log BAF > 5) were found for priority substances.

21 tosphere due to emissions of ozone-depleting substances(9-11).

22 d social support; (2) limited cognition; (3) substance abuse (alcohol and drug); (4) severe psychiatr

23 gia (aOR 1.81, 95% CI 1.49-2.19, p < 0.001), substance abuse (aOR 1.72, 95% CI 1.65-1.79, p < 0.001),

24 impaired decision-making-typified by chronic substance abuse and relapse-observed after drug use.

25 exposure predicts negative outcomes such as substance abuse and traumatic stress disorders.

26 Substance abuse disorders are linked to alteration of ci

27 most prevalent psychosocial risk factor was substance abuse in 1941 (12.6%) recipients.

28 ould be screened for and counseled regarding substance abuse to facilitate a successful quit.

29 group had significantly higher prevalence of substance abuse, sexually transmitted diseases, decompen

30 disorders including depression, anxiety, and substance abuse.

31 the Northeast, and history of depression or substance abuse.

32 s a nexus of frustration, physical pain, and substance abuse.

33 but so were somatic diseases, pregnancy, and substance abuse.

34 emotional abuse; emotional neglect; parental substance abuse; parental mental illness or suicide atte

35 ections for the delivery of iron oxide based substances across the blood-brain barrier for targeting,

36 The transport of substances across the placenta is essential for the deve

37 , including extensive investigation of novel substances active against Gram-negative bacteria.

38 ing technique permits precise control of the substances affecting the chemical reactions, the sample

39 -to-treat (ITT) analysis include male use of substances (alcohol and khat) and women's depressive sym

40 actions were rich in nutrients and bioactive substances and could be useful in the development of nov

41 nfections as well as a wide variety of toxic substances and drugs and systemic immune-mediated diseas

42 their sensitivity for detection of chemical substances and light.

43 Non-volatile substances and molar mass fractions influence sensory pe

44 in the natural environment, where different substances and phases of the same substance forms globul

45 space accumulations of off-flavour volatile substances and thus demonstrated the best retention of s

46 tent class analysis based on any use of each substance, and latent profile analysis based on use freq

47 Lithium is an emerging varroa control substance, and we investigated its accumulation in honey

48 onses against exogenous allergens, microbial substances, and pollutants might occur, rendering indivi

49 ion, entrapment of environmentally hazardous substances, and sensitive and selective nanomaterials re

50 not previously known and where no reference substances are available.

51 to locally released bacterial bitter "taste" substances are most probably initiated by tracheal brush

52 (LSM) were used for the analysis of standard substances as well as complex biological fluids (milk).

53 efining the structure and properties of many substances, as well as phenomena and processes.

54 ated Dienes and Thiobarbituric acid reactive substances assays.

55 le contamination or misinterpretation due to substances associated with disposable laboratory gloves

56 interfacial tension than PFOA, FPOS, or FOSA substances below 100 mg/L, while above 100 mg/L, these f

57 oxide value and thiobarbituric acid reactive substances but high sensory scores than others (P < 0.05

58 l strategy to identify HCPs in antibody drug substance by applying molecular weight cutoff (MWCO) fil

59 The initial response to an addictive substance can facilitate repeated use: That is, individu

60 Alcohol and other addictive substances can remold neural circuits important for memo

61 These substances can significantly disrupt sleep acutely and i

62 infection of cells activates proinflammatory substances, causing diffuse alveolar damage, which is th

63 d offers the possibility for a more detailed substance class mapping.

64 oo little studied but biologically important substance class.

65 e analysis (>5 samples per second) for three substance classes (peptides, antibiotics, and lipids).

66 ochemical profiling) is needed before single-substance considerations.

67 ues become even more important when the drug substance contains an isotope such as deuterium, which h

68 Although the definitive substance or substances contributing to injury have not been determin

69 Most excitingly, the second unknown substance could nevertheless be identified by using comp

70 ons in flexible decision-making functions in substance-dependent individuals are a consequence of dru

71 reened 231 FDA-approved oncology and natural substance drugs included in two NCI drug libraries repre

72 work based on their similarity with unwanted substances (e.g. failed drugs) and (ix) build custom com

73 of accelerated electrons to penetrate into a substance, ELT provides the decomposition of both dissol

74 ty acids (PLFAs) and extracellular polymeric substance (EPS) of biofilms show a S-type trend, the max

75 Extracellular polymeric substances (EPS) are polymers secreted by bacteria to es

76 interquartile range, 2-4); 51.5% were single-substance exposures.

77 supplement in MI and may be a good candidate substance for anti-fibrosis approach.

78 different substances and phases of the same substance forms globules due to differences in pressure

79 Exposure of male fish to estrogenic substances from wastewater treatment works (WwTWs) resul

80 maceutical agents, drugs of abuse, and toxic substances have a large impact, positive and negative, o

81 Ligands within humic-like substances have long been considered important for iron

82 For the other substance, however, this approach proved inconclusive du

83 Natural organic matter and humic substances (HS) in soils and sediments participate in nu

84 Humic substances (HSs) are important electron acceptors and do

85 Humic-like substances (HULIS), extracted from atmospheric aerosols,

86 nterface of refractive index (RI)-mismatched substances (i.e., a discrepancy between the RI of the im

87 n (p < 0.05) against thiobarbituric reactive substances (IC(50) = 23 +/- 2 ug/mL) and oxidative haemo

88 of DPPH scavenging activity in each studied substance identified significant variations in the time

89 rmation of a boron-carbon bond between these substances in a two-step process.

90 nsation compared with stimulation with other substances in all patient groups but not in healthy cont

91 try of humic acid, as a proxy for humic-like substances in atmospheric aerosols, to contribute to sec

92 d diphenyl ethers in fat, and perfluoroalkyl substances in plasma in pelagic and coastal adult female

93 onstituents such as phenolic and antioxidant substances in terms of being useful for human health and

94 ism as it is in charge of transforming toxic substances in the body.

95 , characterization, and quantitation of drug substances in the development of new medicines.

96 A rise of potentially harmful substances in the product water (NO(2)(-), NO(x)(-), NH(

97 that termites contained several paramagnetic substances in their bodies, such as Fe(3+), Cu(2+), Mn(2

98 phorus (P) is increasingly adsorbed to humic substances in this enrichment zone.

99 the potential to treat addiction to various substances, including opiates, alcohol and psychostimula

100 Any infection increased the risk of substance-induced psychosis (hazard ratio=1.30, 95% CI=1

101 predicted conversion to schizophrenia after substance-induced psychosis (hazard ratio=1.87, 95% CI=1

102 of efflux proteins prevents entry of foreign substances into the brain parenchyma.

103 isms that lead to their clearance of harmful substances involve phagocytosis, endocytosis, adhesion,

104 tify target organs in the human body where a substance is estimated to be more likely to produce effe

105 r, the profile overlapping between different substances is addressed by the introduction of an electr

106 s of both known and emerging opioid fentanyl substances is crucial.

107 low skin keratinocytes to disperse bioactive substances is via microvesicle particles, which are subc

108 otic therapeutics based on naturally derived substance library screens for the treatment of cardiac f

109 tigated dissipation half-lives (DT50s) of 31 substances (mainly pharmaceuticals) under different comb

110 But consumption of multiple substances may itself have unique effects.

111 combination of a desorption of exopolymeric substance-metal complexes and a small active efflux duri

112 The ongoing substance misuse epidemic in the United States is comple

113 ted with an increased risk of any subsequent substance misuse outcomes (adjusted hazard ratio [aHR],

114 ociation between ICD diagnoses of TS/CTD and substance misuse outcomes, accounting for psychiatric co

115 associated with various types of subsequent substance misuse outcomes, independently of psychiatric

116 A few new psychoactive substances (NPS) that mimic the effects of controlled ne

117 for the identification of novel psychoactive substances (NPS).

118 identify Old astrocyte specifically induced substance (OASIS)/cAMP responsive element-binding protei

119 The intraocular pressure (IOP), the active substances of the applied IOP-lowering drugs, the best c

120 ting a critical need to monitor HCPs in drug substance or product to ensure product safety and qualit

121 Although the definitive substance or substances contributing to injury have not

122 Substance P (SP), S100beta, GFAP, and phosphorylated mit

123 Activation of the substance P (SP)/neurokinin 1 receptor (NK1R) axis trigg

124 ars critical, nerve growth factor, CGRP, and substance P all appear to be required.

125 ERK, and MMP-1; p <= 0.039) and spinal cord (substance P and MMP-1; p <= 0.041).

126 Colonic IL-6 levels as well as substance P and S100beta density in myenteric ganglia of

127 with secretion elicited by compound 48/80 or substance P but not by FcepsilonRI aggregation.

128 Substance P induced CD301b(+) DC migration to the dLN wh

129 y excitatory interneurons and many coexpress substance P, a marker for a discrete subset of nocicepti

130 ed by vagal sensory axons expressing Phox2b, substance P, calcitonin-gene related peptide, and the se

131 IL-31 when stimulated with a combination of substance P, periostin, and red blood cell lysate (repre

132 e mediators were increased in the periphery (substance P, pERK, and MMP-1; p <= 0.039) and spinal cor

133 ted organics (e.g., per- and polyfluoroalkyl substances), particularly the perfluorinated ones, the d

134 We found that a large fraction of the target substance particulate mass was carried by submicrometer

135 g combustion for remediating polyfluoroalkyl substance (PFAS)-impacted granular activated carbon (GAC

136 Per- and polyfluoroalkyl substances (PFAS) and melamine (MEL)-based compounds are

137 Per- and polyfluoroalkyl substances (PFAS) are a diverse class of industrial chem

138 Perfluoroalkyl substances (PFAS) are a group of widely used persistent

139 Per- and polyfluoroalkyl substances (PFAS) are an ensemble of persistent organic

140 Per- and polyfluoroalkyl substances (PFAS) are anthropogenic, globally distribute

141 Per- and polyfluoroalkyl substances (PFAS) are emerging as harmful environmental

142 Per- and polyfluoroalkyl substances (PFAS) are environmentally persistent chemica

143 e of anthropogenic per- and poly-fluoroalkyl substances (PFAS) are of global concern.

144 Per- and polyfluoroalkyl substances (PFAS) are widespread and persistent pollutan

145 Per- and polyfluoroalkyl substances (PFAS) are widespread persistent organic poll

146 cial sweeteners and per- and polyfluoroalkyl substances (PFAS) as potential tracers for OSPW.

147 effectively degrade per- and polyfluoroalkyl substances (PFAS) at a high concentration (~100 mg/L) an

148 Transport of poly- and perfluoroalkyl substances (PFAS) at aqueous film-forming foam (AFFF)-im

149 ce for an association between perfluoroalkyl substances (PFAS) exposure and attention deficit and hyp

150 hile the effects of poly- and perfluoroalkyl substances (PFAS) have been poorly documented.

151 ver the presence of per- and polyfluoroalkyl substances (PFAS) in biosolids, while sales in commercia

152 renatal exposure to per- and polyfluoroalkyl substances (PFAS), a ubiquitous class of chemicals, is a

153 ntaminants, such as per- and polyfluoroalkyl substances (PFAS), are increasingly found in high trophi

154 Per and polyfluoroalkyl substances (PFAS), legacy chemicals used in firefighting

155 evels of long-chain per- and polyfluoroalkyl substances (PFAS), which pose serious health concerns.

156 Large volumes of per- and polyfluoroalkyl substances (PFAS)-contaminated wastewaters, such as muni

157 compared with other per- and polyfluoroalkyl substances (PFAS).

158 releases of unknown per- and polyfluoroalkyl substances (PFAS).

159 Per- and polyfluoroalkyl substances (PFASs) are a class of environmentally persis

160 tionic, and anionic per- and polyfluoroalkyl substances (PFASs) are identified in aqueous film-formin

161 Per- and polyfluoroalkyl substances (PFASs) are widespread in the blood of the ge

162 Per- and polyfluoroalkyl substances (PFASs) have attracted scientific and regulat

163 The occurrence of per- and polyfluoroalkyl substances (PFASs) in aquatic ecosystems is a global con

164 for characterizing per- and polyfluoroalkyl substances (PFASs) in life cycle impact assessment (LCIA

165 distribution of 29 per- and polyfluoroalkyl substances (PFASs) in seawater was investigated along a

166 Per- and polyfluoroalkyl substances (PFASs) occur in groundwater as mixtures of a

167 of a wider range of per- and polyfluoroalkyl substances (PFASs) onto soils covering diverse soil prop

168 Perfluoroalkyl substances (PFASs) persist and are ubiquitous in the env

169 l contaminated with per- and polyfluoroalkyl substances (PFASs) raises concerns among regulators task

170 storically contains per- and polyfluoroalkyl substances (PFASs) that can be very persistent and pose

171 mpletely mineralize poly- and perfluoroalkyl substances (PFASs) through potential-driven electron tra

172 degrade individual per- and polyfluoroalkyl substances (PFASs), including perfluorooctanesulfonic ac

173 and identify clades with naturally occurring substances potentially suitable for the development of n

174 er against the noxious chemicals and harmful substances present in the blood stream and regulates the

175 lorofluorocarbons (CFCs) are ozone-depleting substances previously thought to be persistent in ground

176 monitoring purification, and evaluating drug substance purity.

177 Overlap of opioids with other substances ranges from shifts among the substances used

178 rs, trauma and stress-related disorders, and substance-related and addictive disorders as well as in

179 ted disorder (aHR, 6.84; 95% CI, 6.32-7.40), substance-related criminal convictions (aHR, 2.56; 95% C

180 victions (aHR, 2.56; 95% CI, 2.36-2.77), and substance-related death (aHR, 2.54; 95% CI, 1.83-3.52).

181 anuloma to the central veins, suggested that substances released from schistosome eggs were responsib

182 ted transcription factors including STAT3 by substances released from tissue-trapped schistosome eggs

183 induced by apoptosis, necrosis or cell lysis substances, respectively.

184 xetine) to 306 days (carbamazepine), with 20 substances responding significantly to bacterial diversi

185 sitivity reactions against normally harmless substances, scientists have started inventing strategies

186 s such as those from the International Humic Substance Society (IHSS), wide-ranging values exist in t

187 inction among analyzed HE materials based on substance spectral signatures.

188 st research suggests that use of psychedelic substances such as LSD or psilocybin may have positive e

189 col, vegetable glycerin, nicotine, and toxic substances, such as aldehydes and heavy metals, has been

190 a functions in the defense against cytotoxic substances, such as antibiotics.

191 2-thiobarbituric acid reactive substances (TBARS), hexanal and propanal formation were

192 Cu-Zn SOD), and thiobarbituric acid reactive substances (TBARS).

193 oxides (PV) and thiobarbituric acid reactive substances (TBARS).

194 Nicotine is another substance that is widely used.

195 oach has enabled detection of HCPs in a drug substance that were not observed in other conventional f

196 970s, an intense race to identify endogenous substances that activated the same receptors as opiates

197 ngermarks made in blood, other biofluids and substances that can elicit a false-positive response to

198 HC is an illicit drug, CBD and CBG are legal substances that have a variety of unique pharmacological

199 mixtures and the presence of polyfluorinated substances that may undergo metabolic transformation.

200 ss, cell aging, and subsequent production of substances that promote chronic fungal infections.

201 he model overpredicted the concentrations of substances that reach this condition after longer period

202 cross the lifespan to simultaneous co-use of substances that span similar and disparate pharmacologic

203 because the opioid crisis includes multiple substances, the opioid specificity of interventions may

204 Our results provide additional substance to a previous report of a functional overlap b

205 owing exclusive direct access of blood-borne substances to hippocampal NSCs.

206 Hs and OPAHs) are some of the most hazardous substances to public health, mainly because of their car

207 possibility for circulation of brain-derived substances to serve as a rapid mode of communication fro

208 rns and neurobiological effects of different substances to understand the range of critical SUD-relat

209 d female genotypes related to the effects of substances transferred by males at mating on female phys

210 r substance use excluding meth (36%), and no substance use (26%).

211 izophrenia (HR = 2.70, 95%CI 1.14-6.37); and substance use (HR = 2.28, 95%CI 1.08-4.80), increased th

212 asthma (RD = 0.76, 95% CI: 0.03, 1.48), and substance use (RD = 0.74, 95% CI: 0.00, 1.47).

213 e different methods to measure the impact of substance use (SU) on population health.

214 se craving, impatience, and actual addictive substance use and 2) do so through mechanisms selectivel

215 This research suggests that integrated substance use and mental health prevention and treatment

216 med the genetic correlations between PAU and substance use and psychiatric disorders.

217 ly correlated with 138 phenotypes, including substance use and psychiatric traits.

218 ed on social media posts of users engaged in substance use and recovery on the forum Reddit, we emplo

219 While men had more lifetime substance use and related consequences, women had more p

220 roups for suicide in the United States, with substance use as a significant risk factor.

221 ences of prenatal parental smoking and youth substance use as they are modifiable and of relevance fo

222 Across 1880 visits, mutually exclusive substance use categories were as follows: 5% meth inject

223 nd is high even in those who did not undergo substance use counseling.

224 r persistent opioid use with past or current substance use disorder (ARI, 10.5% [CI, 4.2% to 19.8%]),

225 olled 801 persons living with HIV (PLWH) and substance use disorder (SUD) from 11 hospitals across th

226 ipment, and unmet needs for medical care and substance use disorder (SUD) treatment.

227 ystems have independently been implicated in substance use disorder and obesity.

228 ent services for the infectious diseases and substance use disorder care continuum.

229 reports suggest that females diagnosed with substance use disorder experience enhanced relapse vulne

230 Relapse vulnerability in substance use disorder is attributed to persistent cue-i

231 People with substance use disorder may be especially susceptible to

232 ocarditis disease burden with related IDU or substance use disorder terms since 2011.

233 ice systems, modeled an average efficacy for substance use disorder treatment, and did not include co

234 nsurance coverage, access to healthcare, and substance use disorder treatment, for many Americans.

235 s, or patients with high rates of concurrent substance use disorder) was 27% (95% CI, 18% to 37%).

236 rbidities, a history of depression, anxiety, substance use disorder, and chronic pain (all P < 0.01).

237 s needle and syringe programs, treatment for substance use disorder, and HIV and HCV treatment, as we

238 midst of an unprecedented epidemic of opioid substance use disorder, and while pharmacotherapies incl

239 lated reward seeking is a central feature of substance use disorder.

240 tive processes governing memory retrieval to substance use disorder.

241 ircadian disruptions are a common symptom of substance use disorders (SUDs) and chronic exposure to d

242 other serious infections among persons with substance use disorders (SUDs) are unknown.

243 s for depression, patients with co-occurring substance use disorders are less likely to receive guide

244 epressant treatment, such that patients with substance use disorders had 21% lower odds of guideline-

245 ssion treatment to patients with and without substance use disorders in a large integrated health car

246 Unlike most medications for the treatment of substance use disorders, anecdotal reports suggest that

247 are common neural characteristics with other substance use disorders, that could inform prevention an

248 iatric, anxiety, depressive, personality, or substance use disorders.

249 have efficacy for the treatment of mood and substance use disorders.

250 ntrolling for potential confounders, such as substance use disorders.

251 costly, chronic diseases such as obesity and substance use disorders.

252 externalizing behaviors relevant to mood and substance use disorders.

253 system disorders including schizophrenia and substance use disorders.

254 en investigated as a potential treatment for substance use disorders.

255 otential therapeutic target for treatment of substance use disorders.

256 5%), meth use without injection (33%), other substance use excluding meth (36%), and no substance use

257 ctive and social consequences of psychedelic substance use in naturalistic settings.

258 ation, which is related to obesity and toxic substance use in young adults, may be associated with po

259 moking, life events, and negative affect and substance use in youth (|rho| = 0.10-0.23).

260 , we investigated the effects of psychedelic substance use on transformative experience, social conne

261 on externalizing traits that predict future substance use problems, half were at low risk, half were

262 nors based on metabolic, cardiovascular, and substance use risk factors.

263 a were used to assess the IDU population and substance use services utilization among RWHAP clients i

264 IDU; among IDU clients, 6.3% (1988) accessed substance use services.

265 d individuals to confirm viremia and link to substance use treatment or primary care with hepatitis C

266 History of participation in substance use treatment was associated with greater like

267 tions included support for HIV infection and substance use treatment.

268 proportion of women not listed due to active substance use was significantly higher versus men (42% v

269 enes and environmental factors (for example, substance use) that may alter disease vulnerability and

270 bipolar or unipolar depression, anxiety, and substance use) to matched healthy control participants.

271 ng ACEs, socioeconomic deprivation, parental substance use, and mental health.

272 , or bipolar disorder, personality disorder, substance use, and number of previously documented psych

273 y factors associated with the development of substance use, but the project has expanded far beyond t

274 Incident mental disorders (mood, anxiety, substance use, personality, posttraumatic stress disorde

275 participants were surveyed for demographics, substance use, risk behavior (previous 3 months), HIV pr

276 therapeutic strategy for managing adolescent substance use-related emotional disorders.

277 with the control group, the hazard ratio for substance use-related mortality among men unemployed fro

278 on genetic risk factors between insomnia and substance use.

279 tion was partially mediated by infection and substance use.

280 to target related risks of mental health and substance use.

281 nd STI-incidence/-seroprevalence, sexual and substance-use behavior data were collected during study

282 Recent animal research on substance-use disorders (SUDs) has emphasized learning m

283 However, substance-use outcomes among men and women, and fatal ac

284 trative diagnostic codes and were grouped by substance used (opioids, stimulants, or both) and site o

285 We evaluated the association between substance used and the outcomes: patient-directed discha

286 ther substances ranges from shifts among the substances used across the lifespan to simultaneous co-u

287 and Word Count and Empath and activities of substance users on various Reddit sub-forums to analyze

288 encing the mental and physical well-being of substance users were found to be positively associated w

289 and persistence, especially for younger and substance-using YBMSM, are necessary to achieve full PrE

290 ders, but also pro-thrombotic medications or substances, vascular and anatomic abnormalities, and und

291 contained plant resin, indicating that this substance was probably applied as a ritual funerary liqu

292 essure of hyphae and extracellular polymeric substances was investigated for biophysical weathering.

293 Median number of ingested substances was three (interquartile range, 2-4); 51.5% w

294 tively high LOD, the LODs of the rest of the substances were 0.1-14.1 mug/kg with a precision of 1.9-

295 While all eight substances were attenuated by at least 60%, five (atenol

296 Eight polyfluoroalkyl substances were detected; perfluorooctanesulfonic acid (

297 ters such as, hydrogen peroxide and reactive substances were significantly elevated (p < 0.01 or p <

298 wn amounts of HCPs to purified antibody drug substance with low levels of HCPs, we demonstrated that

299 ral compound library screening identified 15 substances with antiproliferative effects in human cardi

300 The affinity values of the three spicy substances with hTRPV1 analyzed by molecular docking sim