ライフサイエンスコーパス: substantial

1 y from acute myocardial infarction are still substantial.

2 in Southeast states where the STI burden is substantial.

3 , sex differences in these comorbidities are substantial.

4 f life and body image, its morbidity remains substantial.

5 We observed substantial (13)C enrichment in SMCs that were adjacent

6 SO (Palm-ASO) in mice results in a rapid and substantial accumulation in the interstitium of muscle t

7 rylation and fatty acid oxidation (FAO) with substantial accumulation of acyl-carnitines accompanied

8 antimalarial activities, and they also show substantial activity against schistosomes-another hemogl

9 d several stabilizing mutations which induce substantial activity reduction without distorting the ac

10 diting in primordial germ cells represents a substantial addition to genotechnology in the chicken, a

11 tic analysis of the nephroproteome can offer substantial additional insights, including the discovery

12 or VC of the influenza vaccine could lead to substantial additional reductions in the influenza burde

13 Batch reactor studies demonstrated substantial adsorption of PFOA and PFOS by polyDADMAC-st

14 The past decade has witnessed substantial advances in non-volatile resistive switching

15 While rare TTN(LOF) variants confer a substantial AF penetrance, the additive effect of many c

16 survival and reduction in complications were substantial after allogeneic transplant.

17 There was substantial agreement (kappa = 0.81) between C.D. and K.

18 SKIE achieved a grading accuracy of 90% and substantial agreement (linear-weighted Cohen's kappa 0.6

19 K103NS, M184VI, and G190A (kappa > 0.85) and substantial agreement for Y181C (kappa = 0.720).

20 Without adaptation, the model demonstrated substantial agreement with the original reporting radiol

21 Accounting for chloride changes resulted in substantial alterations in the neuronal input-output fun

22 , mean increases in list and net prices were substantial, although discounts offset an estimated 62%

23 latory and diagnostic potential has gained a substantial amount of attention, the biogenesis of these

24 ng pathway can confer bistability involves a substantial amount of hypothesis testing.

25 ral monocytes and lymphocytes do not express substantial amounts of pro-inflammatory cytokines.

26 Here we use a substantial and diverse set of 3D numerical dynamo simul

27 with subcutaneous xenografts, we observed a substantial and immediate occlusion of the tumour vessel

28 duced considerably: Lockdown measures caused substantial and long-lasting structural changes in the m

29 This substantial and sustained decrease in tumour volume sugg

30 itative RT-PCR, we found that feeding causes substantial and transient changes in gene expression in

31 Nevertheless, individual variation was substantial, and appears to offer the opportunity for co

32 This substantial annotation gap can be reduced with the help

33 The human corpus callosum exhibits substantial atrophy in old age, which is stronger than w

34 , such as gradient metasurfaces, are drawing substantial attention due to their unconventional contro

35 n batteries (SSLIBs) have recently attracted substantial attention from scientists for the advantages

36 he MI (1.01 [95% CI, 0.80-1.27]) resulted in substantial attenuation.

37 diversity and biogeography, which presents a substantial barrier to understanding community dynamics

38 rcise sessions) lifelong exercise results in substantial benefits in exercise capacity ( VO2max ), ca

39 , level and whether the studies will provide substantial benefits that could not readily be obtained

40 tics of the data or are at risk of producing substantial biases in the estimate.

41 suggests that old-growth grasslands support substantial biodiversity and are slow to recover if dest

42 sion to agricultural plantations and risking substantial biodiversity and carbon losses.

43 In contrast to the substantial body of research on the molecular mechanisms

44 n BPA-treated and untreated plants indicates substantial BPA tolerance in both varieties.

45 Our analysis highlights the substantial burden of candidemia in the US.

46 ally increasing, this condition is causing a substantial burden on health care costs.

47 ecrease patient's quality of life, and are a substantial burden on the healthcare system.

48 us antibodies and showed that outgrowth of a substantial but variable fraction of reservoir viruses i

49 Interestingly, hearts in animal species with substantial cardiac regenerative capacity dominantly com

50 umor models, T cells in the tumor experience substantial cell death that is in part mediated by IFN-i

51 f glycosylation genes, which may reflect the substantial cell wall defects in the psd1Delta/Delta psd

52 g discontinuous antigenic epitopes remains a substantial challenge, as exemplified by the case of lip

53 However, modeling copy number evolution is a substantial challenge, because different CNAs may overla

54 Its implementation faces substantial challenges, however; for example, the tremen

55 sents exciting new opportunities, along with substantial challenges.

56 ve been stable or increasing, there has been substantial change in the relative commonness and rarity

57 nvasive crayfish Procambarus clarkii induced substantial changes in multiple phenotypic traits.

58 found that sequence positions which require substantial changes in their local environment across an

59 AP, was highest at 6 h post-injury, while no substantial changes were observed in UCH-L1, Iba-1 or IL

60 temperate latitudes, with several displaying substantial climate change-driven intensification over t

61 trioid ovarian carcinoma (EnOC) demonstrates substantial clinical and molecular heterogeneity.

62 tment with tafamidis is projected to produce substantial clinical benefit but would greatly exceed co

63 describe the use of daratumumab that induced substantial clinical responses in two patients with life

64 t we await further evidence that the model's substantial complexity informs our understanding of fals

65 a reference genome, but the method required substantial computational resources and did not scale to

66 Although substantial concerns about the inflammatory effects of e

67 prefrontal cortex, and ventral striatum, has substantial connectivity with the hypothalamus.

68 ic ice pack during the winter owing to their substantial contribution to the surface energy balance.

69 In particular, RarA makes substantial contributions to intermolecular recombinatio

70 Amazon, indicating that photolysis exerts a substantial control over the atmospheric SOA lifetime, w

71 e complex (PRC) 1 and 2 components indicates substantial cooperativity, but distinguishes a dominant

72 th the current reference genome, but we made substantial corrections within tandem repeat regions.

73 stay of only 3 days, but still incurred both substantial costs ($27.0 million) and unnecessary antibi

74 In contrast, there is substantial cotransport of proteins from distinct domain

75 Modelling results show substantial covariation across tasks, such that an entir

76 formance of neural interfaces while enabling substantial cuts in power consumption.

77 although uncertainty in model prediction was substantial (CV = 28%).

78 scence to middle adulthood, and by a lack of substantial decline from middle to old adulthood, which,

79 tm)), whereby night shift nurses experienced substantial decline-frequently into the "high risk" zone

80 40% and was independently associated with a substantial decrease in all-cause and cardiovascular mor

81 a tipping point, thereby resulting (after a substantial delay) in a selection-induced regime shift.

82 radiographs obtained each day, there can be substantial delays between the time a radiograph is obta

83 To address this issue, we inflicted substantial DG-specific damage in mice of either sex eit

84 n profiles visually exhibited widespread and substantial differences in EGS use and morality.

85 Substantial differences in intake of the other macronutr

86 ity with various elliptical shapes, and with substantial differences in lipid ordering in the centre

87 Our data reveal substantial differences in the circulating antibody spec

88 ittently cloudy day these would translate to substantial differences in total crop carbon assimilatio

89 % CI -0.04% to 0.3%; P = 0.14), but there is substantial difficulty in disentangling the unique assoc

90 Pneumonia constitutes a substantial disease burden among adults overall and thos

91 eatment for severe asthma is associated with substantial disease burden.

92 ive sleep apnea syndrome (OSAS) represents a substantial disease of recurrent sleep fragmentation, le

93 oliferation, but at the expense of incurring substantial DNA damage.

94 esult, ROS-mediated protein damage, which is substantial during the aging of short-lived mice, is sta

95 s of morbidity and mortality, as well as the substantial economic burden, associated with the managem

96 f chicken flocks, the poultry industry faces substantial economic losses by diminished egg quality an

97 he adoption of precision medicine can have a substantial effect on survival in patients with pancreat

98 Preoperative comorbidities can have substantial effects on operative risk and outcomes.

99 these predictors is fragmented and requires substantial effort to find them and to collect and combi

100 F99 pairs in the hexameric channel provide a substantial energetic contribution to Orai1 activation.

101 rimental autoimmune encephalomyelitis (EAE), substantial evidence from patients with MS points to a r

102 Substantial evidence implicates crosstalk between metabo

103 Substantial evidence implicates the nucleus accumbens in

104 We found substantial evidence of secondary infections among house

105 ass traumatic events that are accompanied by substantial financial stressors.

106 Resection tracts averaged 1100 nt, but with substantial fine-scale heterogeneity at individual hot s

107 We suggest that such substantial fitness benefits provide the opportunity for

108 Excess mortality was substantial for severe arrhythmia (univariate hazard rat

109 rsor RNAs serves to regulate expression of a substantial fraction of genes in eukaryotic genomes.

110 tment is lifesaving for some patients, but a substantial fraction of patients initially diagnosed wit

111 landward hydraulic gradients characterize a substantial fraction of the East Coast (>18%) and Gulf C

112 gradient energy) can theoretically provide a substantial fraction of the global electrical demand.

113 loroplast PG in nearly all plants contains a substantial fraction of the unusual trans fatty acid 16:

114 ers in any organism, including those without substantial functional annotations.

115 Overall, this dataset fills a substantial gap in quantitatively describing hippocampal

116 Substantial gaps exist between CDC recommendations for S

117 erosis (MS) is a neurological disease with a substantial genetic component and immune-mediated neurod

118 elian randomization, we show that there is a substantial genetic overlap between voter turnout and bo

119 Very short tandem repeats bear substantial genetic, evolutional, and pathological signi

120 sence of a highly complex virome implies the substantial genomic and pan-genomic complexity of the LU

121 ssing content from genome bins and show that substantial genomic sequence variation is present in a r

122 tors interact in complex ways giving rise to substantial genotype-by-environment interactions (GxE).

123 A substantial global burden of carotid atherosclerosis exi

124 ers of a monogenic risk variant, we estimate substantial gradients in disease risk based on polygenic

125 n in vitro peptide studies) actually retains substantial H3K4 demethylase activity on nucleosome subs

126 editary diffuse gastric cancer can provide a substantial health benefit not only for the patient but

127 Other conditions estimated to have substantial health care spending in 2016 were ischemic h

128 weetened beverage tax designs would generate substantial health gains and savings.

129 Urothelial cancers (UCs) have a substantial hereditary component, but, other than their

130 Family studies have estimated substantial heritability of suicidal behavior; however,

131 gh high-dimensional flow cytometry to reveal substantial heterogeneity in both effector and immature

132 southern Africa and eastern Africa, where a substantial HIV-attributable cervical cancer burden has

133 t climate change mitigation actions can have substantial human health benefits that accrue quickly an

134 arbenes (NHCs) as ancillary ligands has made substantial impact in noble metal catalysis and also sta

135 Diagnosis of an ECI had no substantial impact on long-term survival, health, or soc

136 ion, and in turn, microbiota dysbiosis has a substantial impact on stroke outcome by modulating the i

137 yers, and nanocrystals of lead bromide, with substantial impact on the reaction outcomes.

138 sequences (16S and 23S rRNAs), as well as a substantial improvement on long-distance base pairs (500

139 of protection, the burden of malaria remains substantial in the 2 study areas.

140 usal SNPs explained ~38% of NMR variation, a substantial increase from the ~20 to 30% previously expl

141 Evidence suggests a substantial increase in global photosynthesis since pre-

142 This nanoribbon also displays a substantial increase in molar circular dichroism relativ

143 nterest in Amazonian fires, accompanied by a substantial increase in research in the subject.

144 eport an update of the VDJdb database with a substantial increase in the number of T-cell receptor (T

145 timates of US spending on health care showed substantial increases from 1996 through 2016, with the h

146 In the same treatment scenario but with substantial increases in risk behavior, HCV incidence wo

147 Natural mitigation would require substantial increases in sediment supply well above the

148 Substantial increases in the number of avoidable cancer

149 However, there was substantial individual variation in natural history.

150 Pharmacodynamic studies demonstrated substantial inhibition of phosphorylation of CHK1, the d

151 that are robust on the group level, yet show substantial inter-individual variability.

152 There is substantial interest in liquid biopsy approaches for can

153 This AI system overcomes substantial interobserver variability in expert predicti

154 ameters optimized for each patient indicated substantial interpatient variability.

155 ore than 50 million years(14), pointing to a substantial invasion of aquatic environments by dinosaur

156 s with AF+AFLs had shorter cycle lengths and substantial irregularity versus dogs with AFL.

157 rrence risk for autism spectrum disorders is substantial, leading many families to decline future pre

158 Each of these strategies, however, has substantial limitations.

159 geographically isolated clusters suggesting substantial localized variants.

160 n in the lower two terciles seem to derive a substantial long-term relapse-free survival benefit from

161 athogenic Candida spp. was associated with a substantial loss in bacterial burden and diversity, part

162 y involved in the food trade, it experienced substantial losses in water and land due to the construc

163 MVA-NP+M1 elicits a substantial M1-specific T-cell response, including TRM c

164 We tested this hypothesis by measuring substantial macroscopic CDI, in physiologic conditions,

165 ffects of diversity were significant, and of substantial magnitude, in forests, grasslands, and wetla

166 access to antimalarial treatments to prevent substantial malaria epidemics.

167 The DI is subject to substantial measurement errors due to cell offset from t

168 udal abdomen, mild anxiety-like behavior and substantial memory deficits associated with the presence

169 e management of rheumatoid arthritis (RA), a substantial minority of patients are exposed to multiple

170 al association and leaf venation, suggesting substantial modifications in fine-root morphology during

171 Diarrhea is common and associated with substantial morbidity among hematopoietic cell transplan

172 Allergic asthma causes substantial morbidity and constitutes a public health bu

173 Substantial morbidity and mortality occurred among IC ad

174 lla enterica serovar Typhi (S. Typhi) causes substantial morbidity and mortality worldwide, particula

175 entral nervous system (CNS) infections cause substantial morbidity and mortality worldwide, with moun

176 Influenza infection causes substantial morbidity and mortality.

177 Surgery for rectal cancer is associated with substantial morbidity and mortality.

178 2019 (COVID-19) pandemic is associated with substantial morbidity and mortality.

179 ained cardiac arrhythmia, is associated with substantial morbidity, mortality, and healthcare use.

180 OVID-19 with cardiogenic shock, PPCI offered substantial mortality benefit to patients relative to th

181 ARS-CoV-2) has rapidly become pandemic, with substantial mortality.

182 tibiotic utilization predictions and yielded substantial movement in hospitals' utilization rankings.

183 stress than the commercial lines and showed substantial natural variation in their responses.

184 Substantial necrosis helped identify 65% (17 of 26; 95%

185 isabling, cosmetically disfiguring and has a substantial negative impact on a patient's quality of li

186 This study highlights the existence of a substantial new source of this valuable clay which is cu

187 oparticle-based O(2) imaging, we demonstrate substantial NIR-driven oxygenic photosynthesis by endoli

188 ogressing lesions was low, indicating that a substantial number of lesions appear to continue to bene

189 A substantial number of patients in the ARISTOTLE trial to

190 le to diagnose inherited thrombophilias in a substantial number of patients with venous thromboemboli

191 PRIEVE enrolled a diverse cohort including a substantial number of PWH with reduced kidney function.

192 ing a recent ZIKV outbreak in South America, substantial numbers of neurological complications, such

193 eutic(3,4) and industrial(5) problems, but a substantial obstacle is the myriad of unanticipated cell

194 om the diet is poorly understood and poses a substantial obstacle to harnessing their potential for a

195 Substantial OPA responses were elicited against all sero

196 igh-income countries; and that screening has substantial opportunity costs in low- and middle-income

197 n for a promiscuous enzyme activity provides substantial opportunity for competition between endogeno

198 le range) 1.9 (1.0) vs 1.2 (0.7)), there was substantial overlap in quality between nonprocured and p

199 en by CpGs in intergenic regions that showed substantial overlap with H3K9me3, H3K27me3, and E2F1 tra

200 ters, glaucoma suspect patients demonstrated substantial overlap with healthy and glaucoma cohorts.

201 Irrespective of whether one has substantial perceptual expertise for a class of stimuli,

202 climate change, those indigenous varieties' substantial polyphenol amounts, and the differences betw

203 Unprimed mice harbor a substantial population of 'memory-phenotype' CD8(+) T ce

204 local DNM rate, and that DNM rate explains a substantial portion (8.98 to 34.92%, depending on the mo

205 In addition, a substantial portion of epigenetic alterations in schizop

206 sensitive to warming, creating a potentially substantial positive feedback to climate change.

207 We identified substantial processing differences using a glycoproteomi

208 inct sets of mutated genes derived here show substantial prognostic power and suggest specific vulner

209 olecular imaging of metastases has witnessed substantial progress as an area of clinical inquiry, det

210 For example, substantial progress has been achieved in creating biode

211 atial environment of gene transcription, and substantial progress has been made towards its high-reso

212 he literature where this approach has led to substantial progress in understanding host-microbiota in

213 e among all people living with HIV, and make substantial progress towards achieving 90-90-90 in a rel

214 encing reveals that chromothripsis affects a substantial proportion of human breast cancers, with a p

215 cilities with in-network primary surgeons, a substantial proportion of operations were associated wit

216 In addition, a substantial proportion of patients do not respond to the

217 A substantial proportion of patients in the may be appropr

218 otrophic lateral sclerosis (up to 97%) and a substantial proportion of patients with frontotemporal l

219 espite these improvements in patient care, a substantial proportion of patients, for example, those w

220 le suicide attempt and suicide death share a substantial proportion of their hereditary risk, they do

221 A substantial proportion of these SINEs harbor a high dens

222 Seroconversion (IgA >= 20 U/mL) conferred substantial protection against any and severe rotavirus

223 ts people of all ages and ethnicities, has a substantial psychosocial impact on patients and relative

224 Evidence-based interventions can deliver substantial public health and economic value; however, c

225 OLYP 2 (n = 127) exhibited severe CRSwNP and substantial quality of life impairment evidenced by a me

226 We found that all five ASR systems exhibited substantial racial disparities, with an average word err

227 sufficient for fast desensitization and that substantial rearrangements likely correspond to stable d

228 ultured rat hippocampal neurons results in a substantial reduction in axonal outgrowth and arborizati

229 at BRCA2 tumor suppressor function tolerates substantial reduction in full-length transcripts, helpin

230 Patients with UEL appear to have a more substantial reduction in limb volume differential compar

231 These cell lines exhibit a substantial reduction in total HCP content (40%-70%).

232 emonstrates sub-national actions can lead to substantial reductions and support increased national ac

233 creening past age 75 years did not result in substantial reductions in 8-year breast cancer mortality

234 r the last decade has already contributed to substantial reductions in HIV-1 incidence and mortality

235 oxic highly hazardous pesticides have led to substantial reductions in pesticide-attributable suicide

236 ding on specialty drugs were associated with substantial reductions in spending on specialty drugs am

237 y important mode of migration that generates substantial remittance flows, but raises important conce

238 otal Medicare payments for surgical care are substantial, representing 51% of Program spending in 201

239 ysis and proteomic screening, and identified substantial reprogramming of tumor metabolism involving

240 ethylene-containing compounds have attracted substantial research interest over the past decades for

241 Substantial research over the past two decades has estab

242 e the widespread belief that caregiving is a substantial risk factor for increased inflammation.

243 nd despite the high costs, would still be at substantial risk for a spuriously null result.

244 ally resectable but that resection carried a substantial risk of morbidity because of the potential n

245 These results suggest a substantial role for CD8(+) lymphocytes in suppressing t

246 ho report that the complement system plays a substantial role in creating the hyperinflammation and t

247 ons, the perpendicular components can play a substantial role in the enhancement.

248 Preliminary results demonstrate substantial room for improvement in BP control (<140/90

249 0):998-1010) have demonstrated that there is substantial room for improvement with regards to diversi

250 noise 2D solid-state NMR spectra, yielding a substantial S/N ratio increase while preserving the line

251 This update is a result of a substantial scaling to accommodate constantly growing mi

252 in animals are challenging, however, due to substantial scattering and autofluorescence in tissue at

253 LUAD samples show substantial SCNA and methylation ITH, and clonal archite

254 Na(V)1.7(-/-) showed substantial scratch reduction mainly towards strong prur

255 ons, although it may be prudent to prevent a substantial shift toward early vaccination.

256 mmons has often been a game of catch-up with substantial social costs.

257 uding both roads and transmission lines, are substantial sources of mortality.

258 y demonstrated that MEndoT-derived cells are substantial sources of neovascularization, which can be

259 worthiness evaluation and use it to document substantial, stable individual differences in trustworth

260 f plastics loss into the oceans, including a substantial standing stock, previous research has not de

261 voring higher F-M than M-F transmission with substantial statistical heterogeneity across studies.

262 Continuous learning AI presents the next substantial step in this direction and brings a new set

263 This hybrid interface makes a substantial step towards quantum communication at large

264 lopment of lattice-preferred orientations by substantial stress.

265 Substantial structuring of human populations in Orkney h

266 Substantial suppression of basophil activation was requi

267 PHIP knockdown produced substantial suppression of tumor growth upon intracrania

268 This integrin mAb induces a substantial survival benefit in highly metastatic murine

269 ly diagnosed multiple myeloma to result in a substantial survival benefit.

270 We demonstrate that alphaCD3 alone induced substantial T-cell depletion, impacting both conventiona

271 ties and x-ray free-electron lasers; despite substantial theoretical work the ultimate efficiency of

272 has been hampered by its complexity and the substantial time and human resources necessary for sampl

273 Consequently, therapists spent substantial time performing exercises that elicited litt

274 tercriteria agreement for each site was also substantial to almost perfect.

275 However, CAR T cells can induce substantial toxic effects, and the manufacture of the ce

276 nified in wildlife, such as poor control and substantial trait variation within and among species.

277 nt exchange, the root cortical cells undergo substantial transcriptional reprogramming.

278 s, and Rift Valley Fever viruses), most with substantial transmission in temperate regions.

279 We propose that substantial UDB contributes to the observed antiarrhythm

280 Limitations include substantial uncertainty due to the long-term predictions

281 sms underlies many diseases that represent a substantial unmet medical need.

282 A substantial unmet need remains for safe and effective va

283 's locomotor plant and controller, revealing substantial variability between fish.

284 We found substantial variability in access and that many front-li

285 ow-fat diets can both lead to weight-loss, a substantial variability in achieved long-term outcomes e

286 n estimated 62% of list price increases with substantial variation across classes.

287 There was substantial variation across studies in the proportions

288 .3% (interquartile range, 35.0%-65.9%), with substantial variation between hospitals (adjusted median

289 We found substantial variation in all 23 root phenes measured.

290 We found substantial variation in the degree of placentation amon

291 onses to climate change has been hampered by substantial variation in the rates and even directions o

292 Substantial variations in ambient illumination had no ob

293 , most eyes treated with ranibizumab achieve substantial vision gains, and only older age and better

294 del of lethal HS, despite decreased OCC from substantial volume-expansion.

295 iation in measures of oxidative balance were substantial, we found high consistency in measures of li

296 rce or method, the burden of disease appears substantial, with estimates of thousands of episodes of

297 Our corrections to the genome were substantial, with the length of new genes and tandem rep

298 Substantial within-group variance and overlap between gr

299 There was a substantial within-individual variation on the accuracy

300 eatments of devices with ZnO layer result in substantial Zn diffusion, which can penetrate the full a