ライフサイエンスコーパス: substantial increase

1 ges are likely to have been limited before a substantial increase accompanying the evolution of flowe

2 ation from rRNA-depleted RNA-seq data showed substantial increased accuracy of linear transcript expr

3 d to the dose of intraduodenal leucine, with substantial increases during both 0.15 and 0.45 kcal/min

4 This is a substantial increase from the genetic variance identifie

5 usal SNPs explained ~38% of NMR variation, a substantial increase from the ~20 to 30% previously expl

6 ersonal health care and public health showed substantial increases from 1996 through 2013; with spend

7 timates of US spending on health care showed substantial increases from 1996 through 2016, with the h

8 sel vehicles (count/min) was associated with substantial increases (>100%) in in-vehicle concentratio

9 A substantial increase in abundance of the PAO Candidatus

10 phatidylinositol 4,5-bisphosphate leads to a substantial increase in adhesion area of the sessile GUV

11 th narrow follow-up intervals did not show a substantial increase in AEs during TIs.

12 hough fungicides have greatly contributed to substantial increase in agricultural productivity, their

13 d type 1 diabetic Akita/129 mice exhibited a substantial increase in albumin-to-creatinine ratio (ACR

14 to standard antirejection therapy and had a substantial increase in alloreactive CD8 T cells with a

15 phorylation by the LKB1 complex results in a substantial increase in AMPK activity.

16 lar-KO, but not to control, neurons led to a substantial increase in Asp (3-fold) and NAA (4-fold) le

17 are specific to each ortholog, as well as a substantial increase in asymmetry in the interactions ob

18 diacaran to the early Cambrian, suggesting a substantial increase in atmospheric oxygen level from 16

19 We report a substantial increase in atopy at all ages and in a remar

20 With the substantial increase in BAV utilization and the continuo

21 o PHLDA2 into one-cell zygotes resulted in a substantial increase in blastocyst development, whereas

22 soenergetic replacement does not result in a substantial increase in blood triglyceride concentration

23 obligation in EU waters will likely cause a substantial increase in bycatch rates in longliners, at

24 rough water-conduction nanochannels led to a substantial increase in carbon dioxide (CO(2)) conversio

25 Cells overexpressing Radil show a substantial increase in cell adhesion, as well as in int

26 nditions, only elevated temperature led to a substantial increase in cell maintenance costs.

27 In vivo, Sort1(-/-) mice showed a substantial increase in cellular infiltration of neutrop

28 ese aberrant behaviors were accompanied by a substantial increase in cFos expression in the VTA-proje

29 Dehalococcoides at millimolar levels with a substantial increase in cobalamin (~20-fold).

30 nisotropy experiments, however, results in a substantial increase in complex formation, indicating a

31 no significant trend in droughts, we show a substantial increase in concurrent droughts and heatwave

32 PD and optimized HCD analyses demonstrated a substantial increase in confidence in identification (as

33 rve at the neck in rats, which may provide a substantial increase in connections between the contrale

34 reased the rate to 80% to 95%, though with a substantial increase in cost.

35 imated that, relative to current coverage, a substantial increase in coverage of midwife-delivered in

36 All scenarios allow for a substantial increase in crop production, using an area 1

37 Our result shows substantial increase in CTC capture, compared with seria

38 As well as a substantial increase in data and additions to existing g

39 protein expressed in Escherichia coli with a substantial increase in efficiency over previous methods

40 the lowest baseline eGFR group, there was a substantial increase in eGFR seen during follow-up with

41 A substantial increase in emission intensity with increasi

42 Consistent with the substantial increase in entropy observed in the course o

43 programme in rural India was associated with substantial increase in equitable contact coverage for d

44 This resulted in a substantial increase in F protein synthesis in infected

45 eas LB1-deficient nuclei exhibit primarily a substantial increase in face area.

46 ries (cod and pollock) that have experienced substantial increase in fishing pressure over the past 6

47 A substantial increase in food production is needed for fu

48 Child health received the most substantial increase in funding since 2003 (286%), follo

49 cocultures, while Western blotting showed a substantial increase in GDNF protein.

50 Evidence suggests a substantial increase in global photosynthesis since pre-

51 reliminary results of Phase 2 studies show a substantial increase in growth rate of ACH children afte

52 poprotein B-containing particles, leads to a substantial increase in HDL-C levels.

53 s predicted that vaccination could lead to a substantial increase in hospitalisation because of dengu

54 RS-CoV-2), has caused a worldwide sudden and substantial increase in hospitalizations for pneumonia w

55 (whites, blacks, and Hispanics) experienced substantial increase in hypertension treatment and contr

56 The substantial increase in IHCL seen over this period in bo

57 igh incidence in developed countries and the substantial increase in incidence in developing countrie

58 Despite the substantial increase in internodal length, no significan

59 ovascular glaucoma patient who experienced a substantial increase in IOP associated with severe eye p

60 In a companion study, we demonstrated a substantial increase in Kir2.1 protein occurs in beta-ce

61 ogy, genetics, and imaging has resulted in a substantial increase in knowledge about the development

62 The treated wash showed a substantial increase in lactic, acetic and succinic acid

63 ase in left and right ventricular size and a substantial increase in left ventricular mass.

64 esis in brown adipose tissue is defined by a substantial increase in levels of mitochondrial reactive

65 ling in the liver was also associated with a substantial increase in lipoprotein lipase activity in t

66 fluenza infection has been associated with a substantial increase in local and systemic IFN-gamma con

67 In contrast, there was a substantial increase in long-term mortality after a spon

68 t disease (CHD) and stroke has resulted in a substantial increase in longevity, with subsequent growt

69 RNA-mediated knockdown of TPC2 also caused a substantial increase in melanin content in both MNT-1 ce

70 e, ovarian suppression was associated with a substantial increase in menopausal symptoms, sexual dysf

71 This nanoribbon also displays a substantial increase in molar circular dichroism relativ

72 A substantial increase in molecular complexity occurred th

73 ic fatigue syndrome, but our findings show a substantial increase in mortality from suicide.

74 d-moderate in severity, is associated with a substantial increase in mortality in patients with acute

75 All cities showed a substantial increase in mortality risk associated with m

76 These novel muscle-specific CRMs result in a substantial increase in muscle-specific gene transcripti

77 SLIP-GC-deficient mice experienced a substantial increase in mutations at G:C base pairs at t

78 Concurrently, there was a substantial increase in neo-oligodendrogenesis as manife

79 Interestingly, we observed a substantial increase in Neto2 Ser-409 phosphorylation in

80 We specifically show that 27-OHC induces a substantial increase in NF-kappaB binding to the BACE1 p

81 e of the SCR systems were found to lead to a substantial increase in NH(3) emissions after operation

82 In conclusion, substantial increase in NOAC usage has occurred.

83 among the elderly (increased by 2%) due to a substantial increase in nonvaccine types (NVTs).

84 at elimination of Chop during obesity led to substantial increase in number of adipose tissue T and B

85 geing of the world's population is causing a substantial increase in number of people affected.

86 The substantial increase in open-circuit voltage and reducti

87 oltage fluctuation conditions that include a substantial increase in overall membrane conductance.

88 The hot solid shows a substantial increase in oxygen disorder around the lambd

89 A substantial increase in papillary thyroid carcinoma (PTC

90 show that increasing convenience produces a substantial increase in parking for passenger pickup/dro

91 midst of an opioid crisis that has led to a substantial increase in patients at risk for this vision

92 he offshore and coastal reference sites with substantial increase in PCDD/F concentrations in the mid

93 In AIH/AISC we noted a substantial increase in peripheral blood-derived CD4(+)

94 This treatment of polymersomes resulted in substantial increase in permeability for organic compoun

95 Concomitantly, there is a substantial increase in phosphorylation likely tied to c

96 Here, we analyze the substantial increase in platelet count induced by ALA an

97 d consistently small by LSA standards, and a substantial increase in population size is obvious only

98 missense variant in KCNT1, which produced a substantial increase in potassium channel current.

99 rate advantages of the approach, including a substantial increase in power over competing methods.

100 in future Abeta imaging studies, providing a substantial increase in power over currently used SUVr m

101 We demonstrate a substantial increase in power to detect SCZ associations

102 Our findings show a substantial increase in practice consultation rates, ave

103 The substantial increase in prescription and illicit opioid

104 These 4 early surgery trials showed a substantial increase in procedures in the early surgery

105 s protective effect correlated well with the substantial increase in production of KatB, a Mn-catalas

106 ple challenges including the necessity for a substantial increase in production to meet the needs of

107 B(12) deprivation also caused a substantial increase in reactive oxygen species, which p

108 mono-N-oxide analogue 17a did indeed cause a substantial increase in reactivity of the mustard unit,

109 Confined treatment options and substantial increase in relapse rate after miltefosine (

110 nterest in Amazonian fires, accompanied by a substantial increase in research in the subject.

111 susceptible, PUSA population (Asia-II-7), a substantial increase in resistant ratios was observed in

112 tube IMS and highlight the advantages of the substantial increase in resolution.

113 lts indicate that hippocampal neurons show a substantial increase in responsiveness to task-relevant

114 hese nine LOF variants was associated with a substantial increase in risk of T2D (OR = 7.22; P = 0.00

115 nally stable atropisomeric alcohol, with the substantial increase in rotational barrier arising from

116 BCL11A knockdown was associated with a substantial increase in S/G2-phase human HSCs after engr

117 time available at XFELs and should enable a substantial increase in sample throughput at these facil

118 s with localized surface plasmons allows for substantial increase in sensitivity of chem/bio sensors.

119 infrastructure in Exmouth Gulf will cause a substantial increase in shipping traffic with the risk o

120 These studies were enabled by a substantial increase in solubility compared to previousl

121 increase in mortality and morbidity, with a substantial increase in stroke and systemic thromboembol

122 dynamic perturbation by AF considered led to substantial increase in stroke propensity (i.e., 2.5-3.8

123 erived prostaglandin E2 (PGE2) parallels the substantial increase in stroke-mediated blood-brain barr

124 US enlisted Marines have experienced a substantial increase in suicide rates.

125 nt exchange and desolvation), resulting in a substantial increase in surface area from 725 to 2,749 m

126 Previous studies revealed a substantial increase in surface oxygen content after exp

127 es and clouds is less frequent, leading to a substantial increase in surface shortwave forcing.

128 ignificantly lower all-cause mortality and a substantial increase in survival for both men and women.

129 on from grassland to shrubland resulted in a substantial increase in terrestrial C sequestration.

130 mation encoded by neuronal firing; and (2) a substantial increase in the ability of both single neuro

131 A substantial increase in the abundance of [M + Na](+) add

132 D19 BBzeta T cells and was associated with a substantial increase in the abundance of the most pro-ap

133 onstrained experimental conditions demands a substantial increase in the acquisition speed of high re

134 This resulted in a substantial increase in the amount of F protein expresse

135 This reduction in error resulted in a substantial increase in the amount of genetic variation

136 e assembly of the liquid crystals promotes a substantial increase in the condensation rate of silicic

137 ion of mesothelial ultrastructure revealed a substantial increase in the density of microvilli in DIO

138 d before screening) and more the result of a substantial increase in the detection of small tumors (w

139 er, and (3) multivariate methods may offer a substantial increase in the discovery of genetic variant

140 Compared with their unlocked counterparts, a substantial increase in the emission yield is also obser

141 se in fatty acid (FA) oxidation as well as a substantial increase in the expression of PPARalpha and

142 and contraction force generation, and caused substantial increase in the fibrogenic marker miR-21 exp

143 entify the molecular level mechanism for the substantial increase in the fluorescence signal strength

144 n vivoandin vitro Finally, we demonstrated a substantial increase in the helicity of this region in t

145 suggest that ibrutinib is associated with a substantial increase in the incidence and severity of HT

146 Adolescence is characterised by a substantial increase in the incidence of tuberculosis, a

147 pharmacologic suppression of FasL produced a substantial increase in the influx of tumor-rejecting CD

148 We found no substantial increase in the likelihood of a positive tes

149 in the percentage of myelinated axons and a substantial increase in the mean g-ratio of myelinated a

150 in the percentage of myelinated axons and a substantial increase in the mean g-ratio of myelinated a

151 or Disease Control and Prevention reported a substantial increase in the number of acute hepatitis B

152 The redesigned rrnDB brings a substantial increase in the number of genomes described,

153 are required for gene silencing, providing a substantial increase in the number of identified compone

154 , the organ donor shortage has resulted in a substantial increase in the number of patients who under

155 nt decrease in the power of attacks and (ii) substantial increase in the number of queries needed to

156 eport an update of the VDJdb database with a substantial increase in the number of T-cell receptor (T

157 Overexpression of AtADS2 resulted in a substantial increase in the percentage of glycerolipid a

158 ine, the 2017 ACC/AHA guideline results in a substantial increase in the prevalence of hypertension,

159 ine, the 2017 ACC/AHA guideline results in a substantial increase in the prevalence of hypertension,

160 recommended for hypertension treatment and a substantial increase in the proportion of adults conside

161 sitive troponin assays will likely lead to a substantial increase in the proportion of detectable tro

162 5 mm methyl-beta-cyclodextrin (MCD) caused a substantial increase in the rate of agonist-evoked pore

163 ale genome sequencing is poised to provide a substantial increase in the rate of discovery of disease

164 demonstrate that depletion of CALM causes a substantial increase in the ratio of "open" clathrin-coa

165 sulfate reduction, and were accompanied by a substantial increase in the relative abundance of Desulf

166 of the IFN-stimulated gene signature with a substantial increase in the release of proinflammatory c

167 , population-based cohort study suggested no substantial increase in the risk of cardiac malformation

168 are R47H mutation of TREM2 correlates with a substantial increase in the risk of developing Alzheimer

169 ease stages 3 to 5 and are associated with a substantial increase in the risk of ESRD and ACM before

170 e medications examined was associated with a substantial increase in the risk of severe illness among

171 with external systems by >90% because of the substantial increase in the separation between the subst

172 severe reactions, MCA can be documented by a substantial increase in the serum tryptase level above b

173 This substantial increase in the server capacity is achieved

174 is approximately 25%, and this results in a substantial increase in the signal-to-noise ratio allowi

175 omic integrity in these cells is linked to a substantial increase in the stability of RAD51 at DNA do

176 This paper shows that a substantial increase in the throughput of the TOF MS-bas

177 alyzing genetic variation data have led to a substantial increase in the understanding of genetic var

178 Between 2006 and 2010, we found a substantial increase in the use of broad-spectrum antibi

179 The substantial increase in the worldwide prevalence of asth

180 nanopore sequencing technology have led to a substantial increase in throughput and sequence quality.

181 The Dm-dNK-expressing mice showed a substantial increase in thymidine-phosphorylating activi

182 aboveground large wood pools, resulting in a substantial increase in total system carbon.

183 nsity (BMD), surprisingly caused mainly by a substantial increase in trabecular bone mass, resulting

184 orted in the mug/h/cm(2) range, presenting a substantial increase in transport capacity in comparison

185 We also demonstrated MVA-NP+M1 activated a substantial increase in TRM cells exhibiting effector me

186 We also demonstrated MVA-NP+M1 activated a substantial increase in TRM cells exhibiting effector me

187 ome-wide significant loci, each conferring a substantial increase in TS risk (NRXN1 deletions, OR = 2

188 The HFCS-treated mice showed a substantial increase in tumor size and tumor grade in th

189 0 nm) revealed that laser treatment caused a substantial increase in tumor temperature, from 37 degre

190 ensitivity (1 ppb) can be achieved through a substantial increase in turn-on emission fluorescence in

191 ation on all three stop codons, to provide a substantial increase in unnatural amino acid incorporati

192 2 in double-negative thymocytes and caused a substantial increase in usage of TRAV12 in Tcrd recombin

193 randomized controlled data, there has been a substantial increase in use of percutaneous mechanical c

194 We find a substantial increase in water-use efficiency in temperat

195 consumption of ITF-rich vegetables allows a substantial increase in well-tolerated dietary fiber, wh

196 adoption of longer season cultivars caused a substantial increase in yield ranging from 13% to 38% ov

197 diction method for hybrid yield and showed a substantial increase in yield through genomic hybrid bre

198 ) through day 28 (0.20%; P = .14), driven by substantial increases in 2 participants who received BMS

199 This was compounded by substantial increases in astrocyte reactivity and phosph

200 in contrast, rainfall addition alone caused substantial increases in biomass, whereas fertilization

201 urther demonstrate that dysc mutants exhibit substantial increases in both evoked and spontaneous syn

202 These findings support substantial increases in both short-term and long-term n

203 into classic fluorophore structures elicits substantial increases in brightness and photostability,

204 duals that lived between 1960-2000 indicated substantial increases in C3 herbaceous plants in their d

205 y to enhance T cell function has resulted in substantial increases in clinical efficacy.

206 e reduction in the Raoult effect, leading to substantial increases in cloud droplet concentrations.

207 l motor injury (F2 lesion), which results in substantial increases in contralateral M2 labeling in la

208 ly higher amount of repetitive elements, and substantial increases in copy number and diversity of bo

209 Substantial increases in data availability and in the in

210 ated, because it can result in transient but substantial increases in daytime sleepiness.

211 ka virus (ZIKV) in Brazil has been linked to substantial increases in fetal abnormalities and microce

212 position that we observed occurred alongside substantial increases in forest density, and lead to a l

213 This study shows that substantial increases in handwashing with soap can be ac

214 rdiovascular disease risk, despite producing substantial increases in HDL levels.

215 resents a major health problem, resulting in substantial increases in health care costs.

216 curse of the converted, whereby gBGC causes substantial increases in hereditary disease risks.

217 but not the training add-on, associated with substantial increases in home dialysis, which were ident

218 and nonvascular events were associated with substantial increases in hospital care costs.

219 Ecological comparisons revealed substantial increases in HPV vaccination during this tim

220 Here we report that RTS,S/AS01E induces substantial increases in IgG levels from pre- to post-va

221 do not cause T cell activation do not induce substantial increases in intracellular HIV-1 mRNA in pat

222 Various studies report substantial increases in intrinsic water-use efficiency

223 ent in California non-Hispanic whites showed substantial increases in invasive melanoma incidence for

224 emical stimulation of DMH/PeF neurons evokes substantial increases in IOP, ICP, and the translaminar

225 This led to substantial increases in IPSC activity among WT relay ne

226 by (liquid chromatography) LC/MS identified substantial increases in lactosylceramide in AB-/- mouse

227 These changes in PS resulted from substantial increases in LDL-ApoB-100 FCRs in both group

228 c LSD1 blunted these responses, which led to substantial increases in liver and serum BA levels, seru

229 interventions.Conclusions: We estimated that substantial increases in lung function would occur as a

230 oject the impact of future warming, and find substantial increases in malnutrition depending on locat

231 l Hg was observed in floodwater, followed by substantial increases in MeHg in seston and sediment.

232 after cardiac surgery are common and lead to substantial increases in morbidity and mortality.

233 in node-positive disease was associated with substantial increases in mortality (rate ratios, breast

234 at scale in a low-income setting resulted in substantial increases in mothers' optimal breastfeeding

235 CLP caused substantial increases in mRNAs for IL-1beta and NLRP3 in

236 gene resulted in an enlargement of NMJs and substantial increases in muscle strength and life span.

237 ecovery from P limitation requires rapid and substantial increases in N assimilation and demonstrate

238 PI3K overactivation caused substantial increases in numbers of memory and follicula

239 Despite substantial increases in our understanding of the clinic

240 its mitochondrial dysfunction independent of substantial increases in oxidative stress, but rather ma

241 Tobacco use in PAD is associated with substantial increases in PAD-related hospitalizations, c

242 ducation, a few specialised centres have had substantial increases in patient numbers (in some cases

243 arming at high northern latitudes has caused substantial increases in plant productivity of tundra ve

244 These substantial increases in plasma and urinary dopa and dop

245 tivation of plasmacytoid dendritic cells and substantial increases in plasma interferon-alpha2 levels

246 However, concomitant substantial increases in plasma PYY and glucagon may cou

247 r maintained in vitro than in vivo, allowing substantial increases in platelet storage times.

248 iAEs are independently associated with substantial increases in postoperative mortality, morbid

249 d variance-component tests, they can achieve substantial increases in power.

250 There were substantial increases in pretreatment NNRTI resistance p

251 s more than 40 million people worldwide with substantial increases in prevalence anticipated.

252 Because of the established health risks and substantial increases in prevalence, obesity has become

253 Substantial increases in proinflammatory, antiinflammato

254 LV replication is only slightly inhibited by substantial increases in readthrough frequency, but as w

255 selectivity filter mutation (E191D) yielded substantial increases in relative permeability (P(X)/P(N

256 In the same treatment scenario but with substantial increases in risk behavior, HCV incidence wo

257 multiple genes (apart from NRXN1) and cause substantial increases in risk to develop schizophrenia (

258 Natural mitigation would require substantial increases in sediment supply well above the

259 We have previously observed substantial increases in spectral power in the 25-40 Hz

260 These changes caused substantial increases in steady-state photoluminescence

261 was common among the VCs and correlated with substantial increases in the abundance of mRNAs encoding

262 s process, leukocyte demargination, leads to substantial increases in the clinical white blood cell a

263 species, magnetic measurements demonstrated substantial increases in the concentration of magnetic p

264 Moreover, there were substantial increases in the content of all three cognat

265 y data for breast-cancer screening that show substantial increases in the detection of early-stage no

266 ry transcriptional environment that includes substantial increases in the expression of cytokine sign

267 ethylated promoter CpG positions can lead to substantial increases in the expression of endogenous hu

268 main results in: (i) JNK1/2 activation; (ii) substantial increases in the mitochondrial levels of act

269 Substantial increases in the number of avoidable cancer

270 using the drug praziquantel is resulting in substantial increases in the number of people, mainly ch

271 whether repeated shocks of this kind lead to substantial increases in the prevalence of firearm owner

272 "invisible" supramolecular crosslinks causes substantial increases in the ultimate gel properties wit

273 There were substantial increases in the use of evidence-based medic

274 Despite substantial increases in the use of less invasive ventil

275 Overall, substantial increases in vaccine coverage have occurred

276 decreased in a similar fashion to kh despite substantial increases in xylem area.

277 Median changes in confidence were substantial (increases of 25%, 20%, and 13%, respectivel

278 pared to mfDCA and plmDCA, DIRECT produces a substantial increase of 41 and 18%, respectively, in acc

279 lement to antiretroviral therapy, leads to a substantial increase of all CD4+ T cell subsets in HIV-1

280 Substantial increase of BrC light absorption coefficient

281 oncentration, however, were accompanied by a substantial increase of certain other air pollutants, sp

282 nscranial magnetic stimulation resulted in a substantial increase of EEB, and so did reducing visuo-t

283 ided during cooling, a liquid will display a substantial increase of its viscosity, and will form a g

284 ocal coevolution-based methods, leading to a substantial increase of precision by 19.2 percentage poi

285 with some beneficial effects but also with a substantial increase of risks for harms.

286 The measurements also evidence a substantial increase of the "lifetime" of the electron g

287 ontrol of cell morphology that resulted in a substantial increase of the cell area.

288 Additionally, we observed a substantial increase of the ceratohyal angle of the cran

289 Our experiments indicate a substantial increase of the exchange coupling ratio from

290 exploit extended causal structures, finding substantial increase of the quantum advantage.

291 A substantial increase of the superfluid density and a lin

292 eleton interaction is weakened, resulting in substantial increase of the tensile stress in the lipid

293 IPMK deletion elicits a substantial increase of VEGF (vascular endothelial growt

294 al (3D) liquid-metal (LM) network exhibiting substantial increases of EMI SE when stretched is report

295 This response was accompanied by substantial increases of neuronal calcitonin gene-relate

296 Overall, the substantial increases of nutrients (TN >200%, TP >100%)

297 care delivered to the population, we found a substantial increase over the two-year study period in t

298 These estimated prevalence rates represent substantial increases over the last 2 decades (relative

299 increased in response to perceived risk with substantial increases to toxicity.

300 Since Natsal-2, substantial increases were noted in attendance at sexual