ライフサイエンスコーパス: substantive

1 composition seems to be more structural than substantive.

2 "optimize" binding affinity at the DAT, the substantive activity found for the n-propyl derivative (

3 r repair (numbers needed to harm, four), and substantive adjunctive interventions are needed.

4 ssful or, at a minimum, will have to undergo substantive adjustments before it can be successful.

5 ins an important goal of modern medicine and substantive advances are occurring.

6 er more complex and plentiful in the wake of substantive advances in experimental and computational s

7 In recent years, substantive advances in non-invasive and invasive struct

8 use neither gp49B1 nor alpha(v)beta3 exhibit substantive allelic variation, their newly appreciated i

9 In contrast, loss of xylosylation produced a substantive alteration in the binding behavior of only o

10 V leads to a trunk elongation defect without substantive alteration of cell migration.

11 These findings imply substantive alterations in splanchnic blood flow control

12 all major patterns of temporal expression, a substantive amount of gene expression divergence.

13 ylcarnitine pool) in ischemic hearts without substantive amounts of [3H]eicosenoyl residues in the fa

14 ment protocols had marked heterogeneity, and substantive amounts of data about important outcomes and

15 Substantive and consistent elevations in accommodative l

16 This substantive and continuing shift in body temperature-a m

17 st, have limited the field's ability to make substantive and innovative advances.

18 The most substantive and interesting in terms of the sensory impr

19 nctional and burden of illness measures were substantive and interrelated.

20 neral moderate, in some families the risk is substantive and likely to be the consequence of unidenti

21 that DED is a progressive condition that has substantive and measurable impacts not only on the ocula

22 structural stability, power laws, and other substantive and methodological issues.

23 The incidence magnitude was substantive and persistent throughout follow-up.

24 physicians develop an understanding of basic substantive and procedural law; first, so that their pra

25 Overall, macrophages make substantive and prolonged contributions to fracture heal

26 plementation of these techniques experiences substantive and technical complications (due mainly to t

27 mplete, (2) accurate but incomplete, (3) not substantive, and (4) incorrect.

28 ed and contribute to delirium in independent substantive, and cumulative ways.

29 have focused either on improving conceptual, substantive, and methodologic clarity and precision abou

30 enome and cumulative effects fail to provide substantive arguments against our hypothesis of recurrin

31 r constituents directly on three dimensions: substantive attitudes regarding policy issues, attributi

32 detection of gasoline adulteration and opens substantive avenues for applications in related fields o

33 chieved in this proof-of-concept study opens substantive avenues for characterization and quantificat

34 onic states of Si(2)H(3) and Si(2)H(4), with substantive basis sets.

35 es, and a paucity of baseline data to enable substantive before and after comparisons for affected po

36 MF were consistent with impacts ranging from substantive benefit to neutral effect relative to UC.

37 Cancer immunotherapy offers substantive benefit to patients with various tumour type

38 or researchers and is likely to translate to substantive benefits for patients and health systems.

39 Sites with substantive bioinformatics operations are challenged to

40 A substantive body of evidence found telemedicine to benef

41 acts, clinicians and policymakers require a substantive body of evidence on which to base interventi

42 ng most of the neurosciences, has provided a substantive body of evidence supporting this role of sle

43 A large number of studies offer a substantive body of evidence supporting this role of sle

44 A substantive body of research exists on the psychometric

45 f ZnF-1 led to a partial growth defect and a substantive breakdown of the L-complex, whereas disrupti

46 t that optimizing glycemic control remains a substantive challenge requiring interventional paradigms

47 Biomedical manuscripts undergo substantive change as a result of the peer review and ed

48 ress potential pleiotropic effects led to no substantive change in estimates.

49 ts receiving the low dose of NP2 reported no substantive change in pain.

50 communities demonstrate abrupt nonlinear or substantive change in species composition.

51 Substantive changes in gene expression, metabolism, and

52 urveys, the trends may be harbingers of more substantive changes in less abundant, more sensitive tax

53 No substantive changes in medication adherence were noted a

54 o determine if an intervention that produces substantive changes in the daily living environment will

55 democratic institutions did not predict any substantive changes in the measured cultural values.

56 the 60-month period examined, there were few substantive changes made to the REMS to address evidence

57 ases over Earth history can be used to infer substantive changes to the Earth's surface environment,

58 pite these findings, the FDA did not require substantive changes to the program.

59 ted standard institutional language, with no substantive changes to the protocol.

60 erase components (hTR and hTERT) revealed no substantive changes, which suggests a nontranscriptional

61 that meaningfully influenced their research (substantive citations) and avoid citing works that had n

62 hodological device appears to morph into the substantive claim that humans are actually resource-rati

63 ests that these restrictions may not reflect substantive clinical differences.

64 n the number of participants who experienced substantive cognitive decline (356 assigned polypill, 32

65 standardised baseline scores, the hazard of substantive cognitive impairment was reduced by 14% in t

66 onary, and skeletal muscle physiology into a substantive composite assessment.

67 observations, it is clear that there are no substantive compromises accompanying the use of extensiv

68 We found substantive concentration differences among three major

69 rameter estimates and hence in contradictory substantive conclusions.

70 arrow-sense heritability of 39%, suggested a substantive contribution of genetic factors to BMI varia

71 As its main substantive contribution, the paper demonstrates that on

72 the knowledge needed for clinicians to have substantive conversations with patients.

73 Substantive cooling only occurred during the latter stag

74 ead, analysis of the 11 mutations revealed a substantive correlation between the effect of the amino

75 tatin on CRP was observed, nor was there any substantive correlation between the magnitude of change

76 and first principles calculations show that substantive coupling between perovskite and intergrowth

77 The paper thereby contributes to both substantive debates on the Muslim experience in Europe a

78 Achieving substantive decarbonization via green hydrogen will requ

79 Our mortality model revealed substantive declines of death rates at every age in most

80 ferred dependencies, our simulation yields a substantive decrease in plant taxa richness in response

81 CASI, representing a substantive departure from earlier approaches by shiftin

82 Failure to detect substantive dephosphorylation of activated PKCalpha was

83 There was no substantive deviation in postnatal growth trajectory or

84 SWV did not provide substantive diagnostic information for lesions classifie

85 8%) and afterwards (86.2% to 90.3%), with no substantive difference associated with guideline adoptio

86 e and mutants subunit 6 failed to reveal any substantive difference of the wild type and mutant prote

87 Few substantive differences among the methods were observed,

88 However, substantive differences between humans and laboratory an

89 These data argue against substantive differences between men and women in the lar

90 rioles of the retractor muscle indicate that substantive differences can exist in the nature of signa

91 There were no substantive differences in clinical performances between

92 aining variables, indicating that subtle but substantive differences in microbial communities occur w

93 Qualitative analyses found no substantive differences in the emotional or communicatio

94 minated only after oral training, indicating substantive differences in the processing of these stimu

95 year of clinical fellowship training in CCM, substantive differences in training requirements exist a

96 ity estimates across racial groups found few substantive differences.

97 pport autoregulation of the vicRKX operon or substantive direct regulation of fatty acid biosynthesis

98 during appetitive behaviors, though there is substantive disagreement about the specific purpose of t

99 hreshold of 3-10 microm, but failed to evoke substantive discharge in TRPV1-/- C-fibres.

100 hose surgeon recommended against CPM with no substantive discussion (14.5%; n = 37).

101 dustry representatives, provided much of the substantive discussion from which this VARC-2 consensus

102 legislation has the potential to reduce the substantive disease burden associated with second-hand s

103 rical, and methodological advances across 10 substantive domains of application.

104 nt scores, which assigns equal weight to the substantive domains rather than the components.

105 this decline primarily to the initiation of substantive dust-borne iron fertilization of the Souther

106 Mutagenesis of N121 has a substantive effect on heme binding (K(D) = 3000 +/- 220

107 in games in which individual actions exert a substantive effect on the environmental state.

108 identify rare disease-causing variants with substantive effects on cancer risk from preexisting geno

109 molecular species of each phospholipid have substantive effects on membrane passive ion permeability

110 Although many antioxidants have shown substantive efficacy in cell culture systems and in anim

111 Substantive efforts over the last three decades have foc

112 e postmenopausal women with vaginal symptoms substantive enough to seek medical treatment.

113 s need to combine biomarker development with substantive epidemiologic studies to improve on this ini

114 tly identified new items unlikely to trigger substantive episodic retrieval.

115 On the basis of substantive ethics, clinical practice, policy, and other

116 Overall, there appear to be few substantive ethnic differences in either systolic or dia

117 ssible long-term benefits observed support a substantive evaluation of this community programme.

118 A substantive evidence base supports cardiac rehabilitatio

119 human genome: 47% (35 of 74) of genes showed substantive evidence for a hot spot, and many more showe

120 We conclude that there is no substantive evidence for deforestation at Chaco and no o

121 Our findings provide substantive evidence for RNA G-quadruplex formation in t

122 Together these findings provide substantive evidence for the formation of G-quadruplex s

123 There are limited data with substantive evidence of outcome ascertainment bias, and

124 Together, our results provide substantive evidence of the suitability of hiPSC-based n

125 based recommendations on ECG interpretation, substantive evidence on the training needed to obtain an

126 Control experiments provide substantive evidence supporting the mechanistic cycle an

127 These data provide substantive evidence supporting the use of SGLT2 inhibit

128 bination with toxicological data now provide substantive evidence that chlorinated drinking water lea

129 In addition, we provide substantive evidence that the inhibition of mGluR1/mGluR

130 t of gp78 in Insig-1 degradation, we find no substantive evidence to support roles for either gp78 or

131 effects, and we illustrate this with several substantive examples.

132 -1 in muscle cells, these findings provide a substantive expansion of our understanding of IGF-1 acti

133 intragenerational social mobility provides a substantive expected benefit for adult members to stay i

134 ture coevolution is a framework within which substantive explanations of human evolution must be loca

135 Doing so allows us to learn substantive facts about representation and diversity in

136 xamples of their application in a variety of substantive fields.

137 Our substantive findings suggest that the dominance of an id

138 Children showed substantive gains in cardinal knowledge of number words

139 fertilization and improved maize seed, with substantive gains in productivity for millions of farmer

140 a crucial role in pathogenesis by triggering substantive gene expression alterations to up-regulate t

141 Substantive genetic and phenotypic differences have emer

142 to co-occur, and collectively account for a substantive global disease burden.

143 road areas of opportunity with potential for substantive growth and clinical impact.

144 racism in health care, but few have provided substantive guidance on operational steps to address the

145 f-report fluctuates due to causes other than substantive health changes.

146 A substantive health outcomes trial of invasive versus non

147 prosecute top Khmer Rouge leaders and began substantive hearings in March 2009.

148 However, the substantive heterogeneity in the studies' results and de

149 ires at least 27 separate hybridizations for substantive HPV-type discrimination.

150 imental parameters in LIBS studies present a substantive hurdle for robust classification, even when

151 well tolerated and were not associated with substantive immunologic or virologic changes.

152 latter may lead to an underestimation of the substantive impact of VI on mortality.

153 ionally, PSH site characteristics can have a substantive impact on GWP, with brownfield sites resulti

154 Similarly, the work should have a substantive impact on how genetic variation contributes

155 Ventilator-induced lung injury has substantive impact on mortality of patients with acute r

156 leading cause of untreatable blindness with substantive impact on the quality of life of affected in

157 wever, has been underappreciated despite its substantive impact on the sensing performance.

158 Key conceptual and substantive implications are outlined in relation to bot

159 These results have substantive implications for calculation of recurrence r

160 the origins of the research question and the substantive implications of the debate.

161 a dosage of 30 mg 3 times daily resulted in substantive improvement by increasing the rate of saliva

162 cancer is an ongoing challenge with minimal substantive improvement in patient outcomes despite many

163 machine learning models were associated with substantive improvement in the discrimination of in-hosp

164 otal and HDL-C were in the model, no further substantive improvement was achieved with the addition o

165 n with formal inference systems, can produce substantive improvements in performance over surface-for

166 ed here indicate that it is possible to make substantive improvements in the development of women's c

167 Our focus is on whether such research is substantive in both directions and whether interdiscipli

168 Post-RT SM depletion was more substantive in competing multivariate models of mortalit

169 Running on adulterated fuel leads to a substantive increase in air pollution, because of increa

170 esity epidemic" is paralleled by a rapid and substantive increase in our understanding of molecular p

171 brain complexity, glial cells have undergone substantive increases in cell number, diversity, and fun

172 ttransplant renal function may contribute to substantive increases in resource use, with some variati

173 of health requires research to eliminate the substantive inequities in health care delivery and outco

174 Neither VSV-EBOV nor VSV-EBOVDeltaMLD showed substantive infection of the brains of normal immunocomp

175 nd demonstrate how selection biases can pose substantive inferential hazards in observational studies

176 Conversely, athymic rats produced substantive inflammatory changes that degraded grafts (a

177 Neither new algorithm provided substantive information about women at very low risk bas

178 attendant risk estimations, can provide more substantive information for the individual patient for b

179 rsity of insects, but it is still unclear if substantive insect diversity losses are occurring in int

180 ntigenic challenge with vaccines can provide substantive insight into the status of human immune func

181 m outcome and therapeutic response, yielding substantive insights into mechanisms of hematopoietic tr

182 We conducted a substantive, interdisciplinary literature review focused

183 We posit that proposed substantive interpretations of p do not explain the full

184 the general factor of personality disorder, substantive interpretations of p, and the potential clin

185 ompared with 15 percent of those for whom no substantive interventions were made (P<0.001).

186 Forty-six percent of the patients for whom substantive interventions were made changed their minds

187 eated chronically with losartan suggest that substantive intrarenal actions of Ang II can be maintain

188 Two substantive issues are relevant to discussions of the ev

189 first on the variety of research designs and substantive issues to which SEM can be applied productiv

190 w because these are less likely to represent substantive knowledge flow.

191 icians, methodologists, and researchers with substantive knowledge in the specific area of nutrition

192 nerally assumes that each citation documents substantive knowledge transfer that informed the concept

193 citation classes that are known to represent substantive knowledge transfer.

194 this general overview briefly addresses the substantive law of medical malpractice, informed consent

195 , and feline models with no true macula have substantive limitations.

196 Moreover, we explore a substantive link between large deviation bounds for tail

197 -term graft survival may be possible without substantive long-term immunosuppressive treatment of the

198 d ACR-1, -4, or -5 (aa 447-454), resulted in substantive loss of biochemical activity.

199 n a model of acute pancreatitis, we observed substantive luminal acidification and provide evidence t

200 nce for g in nonmammalian species, for which substantive material exists.

201 These data provide a substantive mechanism linking gonadal hormones to cellul

202 There are few substantive methods to measure the health of the immune

203 king both Yme1 and Taz1 function, there were substantive mitochondrial ultrastructural defects, ineff

204 affect, are too weak to be the basis of any substantive moral judgment and do not fit with the idea

205 taphylococcus aureus (MRSA) infections cause substantive morbidity and mortality in neonates.

206 Influenza B viruses (IBVs) cause substantive morbidity and mortality, and yet immunity to

207 neumocystis jirovecii pneumonia (PCP) causes substantive morbidity in immunocompromised patients.

208 Thus, any further substantive mouse Y-gene functions in spermatogenesis ar

209 However, there is a substantive need for methods that do not require excess

210 ter symptoms had developed did not result in substantive neurologic improvement.

211 In the presence of FIB, substantive non-covalent interactions occurred between r

212 also expressed as a self-protein, additional substantive obstacles are operative within the tumor mic

213 No substantive or statistically significant effects were fo

214 0.05) and was treated as a covariate with no substantive outcome effect.

215 normothermia, there was no evidence that any substantive outcome varied.

216 y managed, and how MPA management influences substantive outcomes remain unknown.

217 he tetracene core is planar and there exists substantive overlap among neighboring pi-conjugated back

218 Substantive overlap with human CCA specimens was reveale

219 tion, the physician implemented at least one substantive palliative intervention, such as control of

220 Substantive palliative interventions lead some--but not

221 vel evidence of a very rapid time course for substantive perceptual changes in tactile location perce

222 ll as the role of theory testing, studies of substantive phenomena, and relevance in consumer researc

223 (two untreated and one preconditioned), and substantive platelet aggregates containing porcine leuko

224 come countries are unlikely to narrow unless substantive policy interventions occur.

225 These results show the first substantive post-exposure protection by a small-molecule

226 and memory of plants to abiotic stress holds substantive potential for improving agriculture.

227 Substantive progress in biological understanding will re

228 we find transcriptional activity explains a substantive proportion (78% and 26%) of the estimated ef

229 that common genetic variation accounts for a substantive proportion of the genetic architecture under

230 Overall, DBA seems to be a substantive proxy for movement-based power but considera

231 e postoperative pulmonary complications as a substantive public health concern demanding national att

232 This article reports the findings of two substantive qualitative studies, both examining similar

233 gant application of theoretical methods to a substantive question.

234 es with tighter cultures have lower rates of substantive/radical innovations yet higher rates of incr

235 elieve our data constitute a mechanistic and substantive rationale for clinical trials of selected MT

236 Fibroblast-ablated mice demonstrated a substantive reduction in cardiac fibroblasts, but fibril

237 ased apoptosis, impaired angiogenesis, and a substantive reduction in the number of invasive carcinom

238 The substantive reduction in the ocean fixed-N inventory at

239 itive to induced polarization resulting in a substantive reduction of the number of waters within the

240 is factor alpha (TNFalpha) blockade provides substantive reduction of the symptoms of rheumatoid arth

241 ers themselves is feasible and would produce substantive reductions in extinction risks.

242 with ACEI versus no ACEI was associated with substantive reductions of risk of nonfatal events (adjus

243 Although there were substantive regional differences in receipt of gender-af

244 science and progressing through a series of substantive research and intervention domains that chara

245 , teaching, and methods to critical areas of substantive research.

246 breadth of the problem calls for an equally substantive response not only from frontline workers suc

247 The substantive results were consistent across all models; t

248 The purposes of this substantive review of alternatives assessment frameworks

249 We conducted a substantive review of EBPH, identified a consensus EBPH

250 full occupancy by water molecules, requires substantive revision.

251 e, the Update Panel concluded that no major, substantive revisions to the 2006 American Society of Cl

252 the relationship of disclosure to patients' substantive rights, and the impact of disclosure on trus

253 clusion HL survivorship is associated with a substantive risk of a second cancer.

254 , addiction to nicotine continues to carry a substantive risk of recidivism.

255 ants toward their cognate Rubisco presents a substantive roadblock to both Rubisco protein engineerin

256 channel activity in bipolar cells suggest a substantive role for an endogenous cannabinoid signaling

257 ork - for it better enables them to defend a substantive role for emotion in moral cognition.

258 of NK cells in PAH and suggests a novel and substantive role for innate immunity in the pathobiology

259 ta types in nearly 1000 patients, we find no substantive role for the lung cancer microbiome in treat

260 esults indicate that the LDN does not play a substantive role in either the generation or the stabili

261 Our results indicate that NPAS2 plays a substantive role in maintaining circadian behaviors in n

262 These findings provide further support for a substantive role of in utero infection or inflammation i

263 n male meiosis, with AtKIN14a playing a more substantive role.

264 biology, there is new evidence that heme has substantive roles in cellular signaling and regulation.

265 ensitivity of the diagnostic test all having substantive roles.

266 ptically detected magnetic resonance (ODMR), substantive room-temperature magnetoelectroluminescence

267 Multiclass analyses offered substantive separation between fresh and aged samples.

268 Simple yet substantive separations of organic reaction mixtures are

269 , with most independent variables yielding a substantive share of statistically significant positive

270 Our findings show that a substantive share of university students support viewpoi

271 Substantive simulation studies under various scenarios d

272 ant throughout the life course, although the substantive size of associations indicated by simulation

273 the Asgard archaea superphyla has provided a substantive step toward addressing this evolutionary que

274 The brain undergoes substantive structural and functional changes with a dif

275 In this update, we report substantive structural annotation improvements for A. ni

276 As predicted, FBXL5-Hr undergoes substantive structural changes when iron becomes limitin

277 These studies provide substantive support for a unique clinical management of

278 the adjacent peptide bond, thereby providing substantive support for the mechanism of HCF-1 processin

279 merging epidemic of CD in the area, giving a substantive support to the World Gastroenterology Organi

280 onetheless, the finding is not without other substantive support.

281 Substantive systematic evidence is needed to clarify thi

282 In substantive terms, use of family names and new historica

283 group, and individual differences; and many substantive themes that cross from psychology into other

284 Our analysis thereby has substantive, theoretical, and methodological implication

285 are in widespread use and have demonstrated substantive therapeutic efficacy.

286 creasing obesity past 51 years of age pose a substantive threat to future gains in life expectancy.

287 The discovery of substantive top-down effects of cognition on perception

288 Given the breadth of substantive topics in the fields of epidemiology and pub

289 nological changes were widespread, revealing substantive transitions in grassland seasonal cycling.

290 ations and methods, and identifying emerging substantive trends.

291 ent of children in high-income countries, no substantive trials have been done of the interventions a

292 orm on the design and resource provision for substantive trials.

293 al targets whose inactivation will lead to a substantive tumor growth arrest.

294 There were no substantive untoward consequences accompanying these hem

295 esults highlight the importance of releasing substantive updates at regular intervals during a crisis

296 ts and assessments have elucidated five core substantive values for ethical allocation: maximising be

297 a paper if they have contributed to it in a substantive way.

298 esence did not benefit glycemic control in a substantive way.

299 contributors: early life education, midlife substantive work complexity, late life leisure activitie

300 e neonatal period in these infants, but less substantive work has explored the long-term impact of pr