ライフサイエンスコーパス: substituent

1 rature, solvent, ancillary ligand, and arene substituent.

2 ough addition of a beta-carbonyl-based polar substituent.

3 i)Pr group are similar to those of the (t)Bu substituent.

4 lectron donor character of the aromatic ring substituent.

5 of the presence or absence of a 1beta-methyl substituent.

6 the configuration of the 13(2)-carbomethoxy substituent.

7 n accompanied by an alkylation of the enoate substituent.

8 H addition at pH 7.4, relative to a hydrogen substituent.

9 bolically labile naphthalene with a haloaryl substituent.

10 y influenced by the nature of the 6-position substituent.

11 manner that is notably independent of the N-substituent.

12 positions with a fluoro, O-methyl, or azido substituent.

13 usion of additional steric bulk of the alpha-substituent.

14 which is neither ortho nor para to a methyl substituent.

15 y aromatic, could be achieved by varying the substituent.

16 oxide independently on the nature of a meta substituent.

17 uaternary centers with four-different carbon substituents.

18 idation of 5mC or demethylation of N4-methyl substituents.

19 onal interactions involving certain triazole substituents.

20 ctivity (up to >20:1 dr) for a wide scope of substituents.

21 ing bearing 13(1)-oxo and 13(2)-carbomethoxy substituents.

22 ctronic polarization induced by the appended substituents.

23 preprogrammed installation of two different substituents.

24 that bear halogen, aryl, and perfluoroalkyl substituents.

25 ps, including C-, Hal-, Si-, S-, Se-, and Sn-substituents.

26 sfully implemented for alkenes bearing alkyl substituents.

27 und for analogous PGCs with ether side-chain substituents.

28 sphocholine (PC) or phosphoethanolamine (PE) substituents.

29 h electron-withdrawing and electron-donating substituents.

30 zation of the positive charge by appropriate substituents.

31 e bond position(s) in unsaturated fatty acyl substituents.

32 ion/deactivation effects exerted by proximal substituents.

33 thout the necessity of additional bulky N(6)-substituents.

34 ating from aldehydes and sterically hindered substituents (2-ClC(6)H(4), 2-BrC(6)H(4), 2-CNC(6)H(4),

35 bond-containing (23a and 23b) or cycloalkane substituents (23e) abrogated the binding to Na(v)1.6.

36 For the first time, very electron-rich substituents (4-Me(2)NC(6)H(4), 3-(OH)C(6)H(4), pyrrol-2

37 tion to introduce the unusual dichloromethyl substituent, a completely diastereoselective rhodium(II)

38 arbon substituents on the double bond, boron substituents accelerate the alkyne coupling.

39 ation of the ring and oxidation of the alkyl substituent accounted for approximately 15-40% of the re

40 ations in the solid state with the P-organyl substituents adopting mutually exo arrangements.

41 uorophores is reported with focus on how the substituents affect the absorption and emission spectra,

42 ctron-withdrawing and electron-donating core substituents affect the rate-determining step of the rea

43 teric, polar, and cationic nature of the C-3 substituents affected intrinsic activity to afford parti

44 ble impact on the optical properties, styryl substituents allow a welcoming extension of the conjugat

45 ide range of electron-rich and electron-poor substituents, allowing tuning of the optoelectronic and

46 tronic effects promoted by the aromatic ring substituents also play an important role in reaction reg

47 =C=C group into the alpha-C-H bond of an iPr substituent and by C-C and P-C bond formation to a new i

48 ructure-reactivity relationship between ring substituent and direct photodefluorination for 16 differ

49 are operating, depending upon the migrating substituent and electrophile used.

50 zation involving the vicinal aryl or hetaryl substituent and the N=C bond of isocyanate, generated by

51 DBF-based protecting group bearing a methoxy substituent and use it to prepare a protected form of cy

52 col accommodates both aromatic and aliphatic substituents and a broad range of functional groups, pro

53 Cyclophanes bearing Me, Et, and MeO cap substituents and beta-Me, Et, or Ph arm substituents are

54 pyrroles bearing an ordered arrangement of N-substituents and C-substituents ranging from coumarin, q

55 ghly efficient, tolerant of a broad range of substituents and can be applied to both carbocyclic and

56 chiral intermediate with two different boron substituents and cobalt bound to the same carbon.

57 spatially aligned X-ray ligands, alternative substituents and compound cores are identified, enabling

58 y can be altered by controlling the chemical substituents and configuration of the CFC structure with

59 ates the assignment of individual fatty acyl substituents and phosphatidic acid moieties.

60 zation by electronic effects provided by the substituents and the reaction rate of the described proc

61 late, an N-linked aromatic or heteroaromatic substituent, and a hydrophobic side chain.

62 effect of the reaction temperature, solvent, substituent, and type of reducing agent using a synergis

63 these compounds have different connections, substituents, and functionalities, their main core can b

64 s, even in the presence of challenging ortho-substituents, and widens the currently available couplin

65 ating that both the type and position of the substituent are pivotal for the design of Cy7-based appl

66 els of enantioselectivity, even when the two substituents are both primary alkyl groups.

67 The strategy wherein trans-dialkyl substituents are installed very early and carried throug

68 -heterocyclic carbenes (NHCs), where the 4,5-substituents are Me, H, or Cl.

69 In addition, alkyl substituents are not tolerated, and the N-H proton of th

70 cap substituents and beta-Me, Et, or Ph arm substituents are obtained, and a modified condensation m

71 ]CPP nanohoops with electronically modifying substituents are reported, accompanied by TDDFT calculat

72 electron-withdrawing and electron-releasing substituents are well tolerated on the phthalide core as

73 them after subtle changes to their appended substituents, are becoming increasingly important and sh

74 The description of substituents as electron donating or withdrawing leads t

75 of ring hydroxylation and oxidation of alkyl substituents as well as a suite of ring-cleavage product

76 position of the attached donor and acceptor substituents as well as the polarity of the environment.

77 in situ-generated 2-en-1-imine moiety of the substituent at C3 makes it possible to construct two new

78 f an isolated oxaphosphetane having a phenyl substituent at C3 of the ring.

79 blocks bearing a pyrid-2-yl or quinolin-2-yl substituent at the 3-position and Pd(0)-catalyzed cross-

80 Introducing an alkoxy substituent at the 6-position onto the phenalenone frame

81 zodioxanes bearing a small, hydrogen-bonding substituent at the 7-, 6-, or 5-position of benzodioxane

82 ed materials, the introduction of a butoxide substituent at the 7-position of the benzocyclobutene pe

83 [a]phenoxazone dye containing a diethylamino substituent at the 9-position.

84 The nature of the substituent at the allene seems crucial for the reaction

85 ic chemistry, describes the preferences of a substituent at the anomeric carbon in glycosides to adop

86 ricyclic scaffolds bearing a trifluoromethyl substituent at the bridgehead position were obtained wit

87 Depending on the steric bulk of the substituent at the isonitrile, migration of a Hyp group

88 The methoxy substituent at the para position changes the direction o

89 ining a pai-donor N-heterocyclic vinyl (NHV) substituent at the phosphorus atom.

90 resence of electron-withdrawing or -donating substituents at C(2).

91 lysis efficiency is favored by electron-rich substituents at C4, giving important insights into the m

92 tetrapyridyl templates with trifluoromethyl substituents at different positions were used to probe t

93 udy highlights that the introduction of aryl substituents at position 23 of the helical moieties has

94 t but also are responsible for the nature of substituents at position 5 of the pyrrole ring in the ne

95 Piperidines with substituents at the 2-position did not behave well unles

96 Systematic incorporation of bulky substituents at the 6-position of the fulvene ring led t

97 y of l- and d-halotryptophans with different substituents at the indole moiety was synthesized employ

98 within a series of analogues with different substituents at the N(3) position, which govern the redo

99 Insights into the influence of the substituents at the phosphorus center on the energy prof

100 tation of ester bonds linking the fatty acyl substituents at the sn-1 and sn-2 positions of the glyce

101 tions identify the thiophene units and cyano substituents at the vinylene linkage as active sites for

102 roup (at the C-4 position) and an additional substituent (at the C-3 atom), in turn synthesized from

103 e complexes with 5'-(R)- and 5'-(S)-C-methyl substituents attached to the 5'- and 3'-terminal nucleot

104 rs, we applied an approach of augmenting the substituents attached to the benzenesulfonamide scaffold

105 We report the incorporation of large substituents based on heavy main-group elements that are

106 ealed approaches to increase potency through substituents believed to enhance separate intramolecular

107 rongly xenobiotic character of some of these substituents, biodegradation of trifluralin does occur,

108 fluorenyl phosphaalkenes with heteroaromatic substituents (bithiophene, benzothiophene, pyridine) off

109 are largely influenced by the nature of the substituents both on the aromatic ring and on the N-tert

110 direct photodefluorination for 16 different substituents, by determining fluoride production rates,

111 lose core bearing polyunsaturated fatty acyl substituents (called phleic acids) and a straight-chain

112 alpha-alkylation was overcome by appropriate substituent choice, leading to enantioselective synthese

113 Dopamine-derived N(6)-substituents, compared to N(6)-(2-phenylethyl), in trunc

114 These substituents contained well-known R-groups as well as no

115 o-(Trifluoromethyl)phenyl substituent contributes to stereoselectivity of 1,3-dipo

116 Quantifying chemical substituent contributions to ligand-binding free energie

117 reveal a mechanism wherein the beta-carbonyl substituent creates a structural buffer between the dono

118 olidin-2-ones bearing new functionalized C-5 substituents derived from conjugated 1,3-dienyl and cumu

119 The increased size of the substituents determined the spatial limitations of the a

120 om competing cyclometalation of chelate aryl substituents, deuterium labeling experiments were consis

121 with electron-donating or -withdrawing ring substituents displayed decreases in cation exchange-norm

122 es and several pyrrolidines carrying bulky 2-substituents, due to reversibility of the initial attack

123 luence of the donor/acceptor strength of the substituent E on the photophysical properties has been e

124 luster cage and an exopolyhedral boron-based substituent (e.g., -BF(3)K, -B(OH)(2)).

125 -[BDan] (BDan = 1,8-diaminonaphthalatoboryl) substituent each were hydrogenated in high yield and ena

126 culations have been performed to explore the substituent effect on benzene's structure and aromaticit

127 4n and Huckel's 4n + 2 rules, together with substituent effects (electronic and steric) and benzanne

128 ascade proceeding by both pathways including substituent effects and KIE.

129 anate ligands and demonstrate how electronic substituent effects can be used to modulate the thermall

130 Additionally, substituent effects were investigated in order to give f

131 Kinetics, substituent effects, computational modeling, and spectro

132 n by the preformed AB ring system and subtle substituent effects.

133 otherwise difficult to access via classical substituent effects.

134 icant differences result from intramolecular substituent effects.

135 enes carrying opposing strong donor-acceptor substituents either along the long axis of the molecule

136 e utilized to generate TATBPs with different substituents either in the meso-positions or the periphe

137 The amino group must carry two substituents, either two aryl, one aryl and one alkyl, o

138 terfly-shape pyrene ligand with a tert-butyl substituent enables the formation of the disordered 12-c

139 2 B-H vertices with alkoxy or benzyloxy (OR) substituents engenders reversible redox chemistry, provi

140 e slope indicating that electron-withdrawing substituents enhance the radical-cation acidity.

141 Peptides featuring backbone N-amino substituents exhibit unique conformational properties ow

142 Substituent factors of F(-Si(CH(3))(2)OR) and F(-SiCH(3)

143 The alkynyl substituent favorably tunes catalyst solubility, aggrega

144 on repulsive interaction from opposing ester substituents favors Chair.

145 indicated a crucial role for both meta-nitro substituents for antitubercular activity, while the intr

146 ate the influence of isomerism of the -NO(2) substituents for the electrocatalytic multi electron oxi

147 r that, functional monomers derivatized with substituents forming stable complexes with the templates

148 of compounds that can be tuned by choice of substituents from Baird-antiaromatic to Baird-aromatic i

149 -energy calculations to prioritize different substituents from the large accessible chemical space.

150 Steric shielding due to the bulky P-substituent gives marked different reactivities at the 2

151 ng both electron-rich and electron-deficient substituents, giving good yields of the N-heterocycle pr

152 The magnitude of SOC can be tuned by the substituent groups (e.g. heavy atoms, carbonyl moieties)

153 Notably, the substituent groups on the meta-positions alter both the

154 bstituted carboxymethoxy and N-benzylglycine substituents had high antischistosomal efficacies.

155 rents and the presence of the internal alkyl substituents had little effect on the global aromatic ch

156 icate that the electronic nature of the para-substituent has a different influence depending on wheth

157 sized to investigate the impact the chlorine substituents have on the photodegradation rate and the p

158 esence of three influences from the selected substituents: hyperconjugative, resonance, and electrost

159 Using the beta-carbonyl substituent, improvements in the photophysical propertie

160 tep is not compatible with dCTP or the bromo substituent in beta,gamma-CHBr-dNTP analogues.

161 The same substituent in different positions of the chain often ex

162 Finally, we show incorporation of a methyl substituent in one of the carbon atoms of the DKP ring t

163 dity of its pai system, which depends on the substituent in the 4,5-positions of the imidazolylidene.

164 nt tetrahydrofuran derivatives with an amino substituent in the side chain is reported.

165 steric repulsions involving the pseudoaxial substituent in the six-membered allylation transition st

166 es on the impact of the steric demand of the substituent in the ylide-backbone on the catalytic activ

167 Here, we demonstrate that the A-site substituent in yttrium ruthenium pyrochlores Y(1.8)M(0.2

168 of methine groups with heteroatoms or other substituents in aromatic or heteroaromatic ring-containi

169 relative "head-to-tail" arrangement of the N-substituents in Bn(4)Me(4)BU[4], 5a, clearly observed by

170 the macrocycle along with the trans-dialkyl substituents in both pyrroline rings (B and D).

171 s depend on internal nucleophilicity of aryl substituents in CF(3)-pentenynes and external nucleophil

172 ibrary of Cy7 derivatives containing diverse substituents in different positions of the heptamethine

173 s (sigma-holes) on the surface of the iodine substituents in I(4) Q(-.) responsible for the attractiv

174 oactive alicyclic amines containing variable substituents in multiple ring positions typically relies

175 arise when photoisomerization of spiropyran substituents in pH-responsive poly(acrylamide-co-acrylic

176 Swapping the substituents in positions 2 and 4 of the previously synt

177 ate)s (PGCs) containing carbonate side chain substituents in the 2- and 3-positions, whereas regioirr

178 ith different electron-withdrawing or -donor substituents in the benzene ring are higher than that of

179 The N-substituents in the electrophile influence the reactivit

180 In the divergent synthesis, p-Cl substituents in tris(4-chloro-2-pyridylmethyl)amine (TPM

181 d the pai-donor is an electron-rich aromatic substituent, in particular, the 1-pyrrolyl or the 4-hydr

182 rs, structurally modified by core and bridge substituents, in methanol and aqueous solutions are repo

183 (4), with electron-withdrawing or -donating substituents increasing or decreasing the strength of ex

184 an be achieved by simply introducing a small substituent into the 2-position of AOPCP without the nec

185 ectivity through the divergent projection of substituents into both the "selectivity" and "alkyl-indu

186 SAR around the C-3 substituents investigated effects on NOP binding, intrin

187 The P-fluoro substituent is exchanged for hydride by treatment with D

188 utational data suggest the nature of the 5-R substituent is key in directing the inter-ring angle and

189 an electron-donating or electron-withdrawing substituent is to increase the stability of both arene a

190 We demonstrate that a wide array of substituents is tolerated with this novel scaffold that

191 force spectroscopy reveals that the methoxy substituent lowers the force required for rapid (k(open)

192 Substituent migration occurs in some cases.

193 deacylating water by the 6alpha-hydroxyethyl substituent of carbapenems.

194 s deficient in heptose II and the phosphoryl substituent of heptose I of the inner core lipopolysacch

195 2-7 explained how charge, conformation, and substituent of iminocyclitols affect their potency and s

196 yst influence the orientation of alpha-vinyl substituent of the allylboronate reagent to occupy a pse

197 is reported that occurs at the aliphatic C3-substituent of various quinolones and pyridones.

198 O-Acetyl moieties are the dominant backbone substituents of glucuronoxylan in dicots and play a majo

199 wing groups placed on the N-vinyl and N-aryl substituents of hydroxypyridinium ion salts lead to enha

200 Hydrophobic C2 substituents of sufficient size generally provide for po

201 al changes to the C-3, C-4, and C-5 position substituents of the core pyridine ring afforded compound

202 teractions through fine-tuning of the remote substituents of the D(2)-symmetric chiral amidoporphyrin

203 the reaction, which can be tuned through the substituents of the heteronorbornadienic systems.

204 strongly affected by the nature of the para substituents of the substrate during the OAT step, a rea

205 Varying the substituents of the trimethoxyphenyl moiety gave rise to

206 modation in the membrane for the hydrophobic substituents of transported drug-like cations.

207 Adding an ortho substituent on one phenyl ring of a prochiral diazo enha

208 Modification of the substituent on the bridging 5,5'-R(2)bpym radical anion

209 ticularly on the importance of the end-group substituent on the crystal packing of nonfullerene accep

210 ncorporation of a radical-stabilizing phenyl substituent on the cyclopropyl group.

211 cells, we demonstrated that an acid group as substituent on the imidazobenzodiazepine scaffold leads

212 mputational analysis, the role of each ortho-substituent on the mechanism and rate of conformational

213 ring a hydroxyl, an acetate, or an acetamide substituent on the N-tert-butyl moiety and para-substitu

214 ould be accessed by the choice of ligand and substituent on the propargylic amine, leading to a stere

215 etriones (SPTs) incorporating N-linked azole substituents on a benzisoxazole scaffold with improved G

216 strate scope of this reaction by varying the substituents on aromatic nitriles and amino thiols and t

217 The steric effects of substituents on five-membered rings are less pronounced

218 nstrate that, depending on the nature of the substituents on positions 3, 4, and 5, this scaffold lea

219 he type and relative position of fluoroalkyl substituents on the acidity and lipophilicity of monofun

220 the xyloside moiety and the influence of the substituents on the alkyne part.

221 ntally observed only for triads with certain substituents on the anthracene and the pyridine.

222 the sulfonylpyridine molecule by introducing substituents on the aromatic regions.

223 nto substituent space and identify preferred substituents on the basis of analogue series.

224 96 to +1.64 V vs Fc(+/0), depending upon the substituents on the benzene ring.

225 ctions are absent in the complex with phenyl substituents on the borate backbone.

226 ere, we report the influence of halogen para-substituents on the crystal structure of benzylammonium

227 ritical requirement of having at least three substituents on the cyclopropanecarboxylate ligands to h

228 In contrast to carbon substituents on the double bond, boron substituents acce

229 ], both of which involve positively charged substituents on the outer circumference of the respectiv

230 hosphasilenes with Mes, Tip, Dur, and NMe(2) substituents on the P atom, using muon spin spectroscopy

231 itration experiments reveal that the methoxy substituents on the p-phenylene linkers do not influence

232 to different starting materials with various substituents on the phenyl ring and varied functional mo

233 ethylgermanyl)-4-methoxyphenyl groups as the substituents on the phosphorus, as a new ligand that for

234 ar activity, while the introduction of polar substituents on the quinazolinone core allowed reduction

235 |g(lum) | up to 0.240) by introducing chiral substituents onto the macrocyclic scaffolds.

236 nides, in particular on the influence of the substituents onto the structural and energetics paramete

237 endent role of isomerism of secondary sphere substituents over their nature, a factor often overlooke

238 In the aryl ether moiety, substituents para to the nitrile demonstrated an electro

239 never systematically studied, that the ring substituents play an important role on the direct photoc

240 rk analysis revealed that chemically similar substituents preferentially occurred at given sites and

241 inding orientation of the different chemical substituents proposed.

242 Compound 35, bearing a para-benzyladenine substituent, proved particularly potent against USA300 a

243 gen in combination with variable N(2) simple substituents provided novel analogues with increased AR

244 One of these, in which the glycol substituent provides an enhanced water solubility withou

245 ordered arrangement of N-substituents and C-substituents ranging from coumarin, quinoline, phthalimi

246 substrate and analogues with different para substituents ranging from electron-donating groups (e.g.

247 ions with the "C-H"-groups of the cyclohexyl substituents result in an unusual low-spin square planar

248 ay photoelectron spectroscopy suggest that a substituent's isomerism in molecular catalysts conjoins

249 Compounds with a 2-methoxy substituent showed a faster cross-linking reaction rate

250 ts of our analysis provide new insights into substituent space and identify preferred substituents on

251 ysis concept for the exploration of chemical substituent space that is based upon bioactive analogue

252 These calculations predict that substituents stabilizing negative charge on the pyridine

253 Substituent steric and electronic perturbations across a

254 readily accessible properties of the linker substituent, such as the Hammett sigma-constant or elect

255 ting or withdrawing effect of the peripheral substituent ((t)Bu vs. CF(3), respectively) and its infl

256 Di-p-methoxyphenylamine (DMPA) substituents tailored to the central SBA-platform define

257 to select aptamers with large hydrophobic 2' substituents that bind human neutrophil elastase or the

258 o) ligand [L(Ph)](3-) with bulky m-terphenyl substituents that can host two Ni-H units in close proxi

259 ed that it is the nature and position of the substituents that determine their activity and selectivi

260 ylureas typically functionalized with F or P substituents that may be readily converted into alpha,al

261 The method is versatile, tolerating substituents that vary in size and that bear a range of

262 Apart from the aromatic substituent, the benzylic leaving groups greatly affecte

263 In the presence of the benzyloxy substituent, the high selectivity for the cis isomer is

264 Without either of these substituents, the environmental fate of triclosan would

265 of aryl sulfonates with electron-withdrawing substituents, the rate of deprotection for the correspon

266 action proceeds via exchange of the NR and O substituents through intermediates featuring an aluminiu

267 ffered in the number and location of methoxy substituents, through in vitro assays: MCF-7 cell prolif

268 1,6-zwitterion interceptors allows the alkyl substituent to be grown to give the corresponding acycli

269 undergo hepatic oxidation of its 2-naphthyl substituent to produce two regioisomeric 1,2-dihydronaph

270 e simultaneous introduction of more than one substituent to unprotected amines has never been accompl

271 elated to destabilizing steric clash between substituents upon ring-opening.

272 Subject to the size and nature of the 2-substituent, variable binding modes were observed by X-r

273 lky bisphenol and 1,1'-bi-2-naphthol-derived substituents via the functionalization of a readily acce

274 In addition, the 2'-Cl substituent was critical for the high quantum yield meas

275 on of the lipophilic ribose pocket-targeting substituent was followed by the introduction of a variet

276 The key pendant aryl substituent was modified by (i) introducing polar functi

277 ariation based upon the nature of the amidic substituent was observed for any of the N-(hydroxybenzyl

278 e chain cis to the bulky octahydronapthalene substituent was pivotal in fashioning the challenging co

279 The 4-Cl substituent was responsible for higher rates of light ab

280 2)C(6)H(3)] (LH), containing two different N-substituents was prepared by the direct reaction of the

281 To offset the increased size of this substituent, we also removed the para i-Pr group of the

282 intramolecular stabilization by a ferrocene substituent, we have characterized the zwitterionic inte

283 hosphinite pincer ligand and bulky substrate substituents, we demonstrate how the mechanical bond can

284 The best results were obtained when substituents were added at the C4 position, which improv

285 More importantly, the substituents were found to have a substantial effect on

286 caffold, whereas various alkyl and aryl urea substituents were introduced after a yield-limiting macr

287 3-Arylated benzofurans bearing various substituents were obtained with good to excellent yields

288 opylamines bearing CH(2)F, CHF(2), and CF(3) substituents were synthesized by different methods on a

289 pairs carrying various electron-withdrawing substituents were synthesized with selected ammonium or

290 id organocatalysts with electron-withdrawing substituents were synthesized, and their relative acidit

291 tho-tolyl (pinkYPhos) and mesityl (mesYPhos) substituents were synthesized, which are slightly more s

292 h electron-withdrawing and electron-donating substituents were tolerated.

293 alpy of formation depending on the choice of substituent, which is accompanied by only a small change

294 subsites of 21 is functionalized with alkyl substituents, which are shown to effectively modulate bo

295 installed at the beta-position, aminomethyl substituents with amine pK(a)'s > 7 accelerate, while th

296 nthracene will favor the LEPT pathway, while substituents with the reverse effects will favor the CSS

297 tertiary alcohols bearing an adjacent ester substituent, with both reaction conversion and enantiose

298 lexes, featuring unprotected carboxylic acid substituents, with Cu(OAc)(2) .

299 otides are readily functionalized with CF(3) substituents within the nucleobase.

300 It was a surprise that the effect of the substituent X on the extent of the structural rearrangem