ライフサイエンスコーパス: substitution

1 ramatic drug potency enhancement via halogen substitution.

2 lization, and a final electrophilic aromatic substitution.

3 nger to RAG-1, here we employed phylogenetic substitution.

4 entrosymmetric oxides through rare-earth ion substitution.

5 ate isogenic lines that varied for the F187Y substitution.

6 the focus is on packaging waste or feedstock substitution.

7 combination with the uncoupling p.Glu200Ala substitution.

8 is changed to NPHK with a D -> N amino acid substitution.

9 s are mutually exchangeable by a single-base substitution.

10 pound through trinucleotide patterns of base substitution.

11 es of DNA errors: insertions, deletions, and substitutions.

12 ree positions containing K1I, H18R, and A25T substitutions.

13 th of this gene, including two nonsynonymous substitutions.

14 vage was only moderately enhanced by similar substitutions.

15 is consisting of two subsequent nucleophilic substitutions.

16 an release and can also eliminate phosphoryl substitutions.

17 3)-homo amino acid in position 8 and Tyr(11) substitutions.

18 f which impact the resulting distribution of substitutions.

19 We identified 49 single-base-substitution, 11 doublet-base-substitution, 4 clustered-

20 49 single-base-substitution, 11 doublet-base-substitution, 4 clustered-base-substitution and 17 small

21 Finally, applying space-for-time substitution, a strong antagonistic (i.e. dampening) int

22 is that multimers could become entrenched if substitutions accumulate that are neutral in multimers b

23 ble pairs, and splints with G to I (Inosine) substitutions all allowed for the efficient assembly of

24 doublet-base-substitution, 4 clustered-base-substitution and 17 small insertion-and-deletion signatu

25 were confirmed by (13) C and (15) N isotopic substitution and comparison with frequencies calculated

26 show superior stability toward electrophilic substitution and cyclometalation chemistry.

27 uding rarely reported quaternary nitroalkene substitution and heteroaromatic and hindered ortho-subst

28 chondrial genomes contained 82 intraspecific substitution and insertion/deletion mutations, and provi

29 phase detuning is utilized via isovalent La substitution and thickness scaling in multiferroic BiFeO

30 33 surface-exposed residues in RD3 by single substitutions and deletions to identify side chains that

31 How do substitutions and functionalities impact the activity an

32 ng several distinct mutational signatures of substitutions and of insertions and deletions.

33 gene copy number increases followed by base substitutions and, finally, contraction of the gene copy

34 E-enone (via Nazarov, electrophilic aromatic substitution, and elimination reactions) gave BC-1 (53%

35 splay broad activity, tolerating a number of substitutions, and diphosphate and monophosphate analogu

36 rostyrenes by ozone/Fe(II) -mediated radical substitutions, are reported.

37 olarity and that a tyrosine to phenylalanine substitution at a binding site could be detected.

38 ontaining a threonine (Thr) to alanine (Ala) substitution at amino acid 79, failed to induce these ph

39 ion is a formal stereoretentive nucleophilic substitution at an oxygenated tertiary carbon.

40 much greater extent than decoration at C(7), substitution at benzodioxane C(5) confers very high alph

41 (DOTA)-conjugated CCK2R ligands with proline substitution at different positions were synthesized.

42 d as R3 or R4 had the same proline-to-serine substitution at p106.

43 IV) incorporation into magnetite via Fe(III) substitution at pH 10.00 +/- 0.04.

44 ition, we show that a methionine-to-arginine substitution at residue 58 impairs Orf6 binding to the N

45 Both series have variable substitution at the C-4' position (i.e., OH, Cl, F, H, O

46 a bearing truncation or glutamate-to-alanine substitutions at distal NT causes constitutive cell deat

47 Changes may be triggered by substitutions at epistatically interacting sites elsewhe

48 Amino acid substitutions at peptide position 1 predicted to alter t

49 stone mutations include lysine-to-methionine substitutions at positions 27 and 36 of histone H3.3.

50 nical trial data revealed that PA amino acid substitutions at residue 38 (I38T/F/M) reduced BXM poten

51 Thus, substitutions at rheostat position 267 had wide-ranging

52 esulfonamide scaffold in three ways, namely, substitutions at the 3,5- or 2,4,6-positions or expansio

53 Conversely, phosphorylation-blocking substitutions at these sites enhanced ICAP1 nuclear accu

54 Substitutions at Thr-2 that precluded N (alpha)-acetylat

55 estimate that at least 20% of nonsynonymous substitutions between humans and an outgroup species wer

56 Wheat flour substitution by CF, GF and RF in bread reduces heat tran

57 in PR with resistance-associated amino acid substitutions by formation of optimal sulfur bond and ad

58 The P339A substitution, by contrast, has little effect on KPNA7 bi

59 However, synonymous codon substitutions can affect many distinct cellular processe

60 ighly atroposelective electrophilic aromatic substitution catalyzed by a chiral-at-metal rhodium Lewi

61 ary approaches: perturbation, visualization, substitution, characterization, reconstitution, and simu

62 nic environments, providing access to facile substitution chemistry at both electron-rich and electro

63 a common ancestor of Juglandaceae using site substitution comparative analysis.

64 A synthetic cycle for aryl C-F substitution comprising oxidative addition, ligand metat

65 selective transformations, including allylic substitutions, conjugate additions, proto-boryl addition

66 d models (cake and beef burger) with partial substitution CW2%/AA4% oleogel as the optimized sample s

67 Substitution did not affect CCK2R affinity, and the conj

68 der the curve relative to those without, but substitutions did not significantly affect peak viral lo

69 rovides insight into how specific amino acid substitutions distant from the active site in a Klentaq

70 To elucidate their properties, solvent and substitution effects on their light absorption, thermal

71 o humans and poultry, the impact of these HA substitutions, either individually or in combination, on

72 A human FAAH 385C->A substitution encodes an FAAH enzyme with reduced catabol

73 Here we show that synonymous codon substitutions encoding a single essential enzyme lead to

74 However, we noted that the N53I substitution exposes an additional hydrophobic surface a

75 d mutagenesis, we demonstrate that the M159I substitution extends the temperature optimum of the most

76 This variant causes substitution F302L, in helix S4 of the K(V) 1.2 voltage-

77 Ala substitutions for most alphaM4 residues, including those

78 On the other hand, Ala substitutions for Thr422 and Arg429 caused relatively la

79 utagenesis reinforced the importance of R225 substitutions, found in 100% of selected variants.

80 n models were generated to predict carbonate substitution from peak position within the PDFs.

81 uctural stability for the epitope, while the substitution G172E probably compensates for loss of fitn

82 Specifically, we observe that a G545S substitution hinders rotation of the beta3 strand necess

83 -boryl additions to alkenes, boryl and silyl substitutions, hydride-allyl additions to alkenyl borona

84 We demonstrated that substitutions I38L/M/S/T not only had a differential eff

85 ose that combining specific SIRT6 amino acid substitutions identified in enzymology studies and activ

86 e strength of which was reduced by the R289A substitution, implicating this interaction in the observ

87 ith predicted effects of the novel Asn117Lys substitution in ACTA2.

88 ent in 22% of the population causes an R154Q substitution in an extracellular loop of SLC44A2 that is

89 rom the ChH1A cluster, whereas only a single substitution in antigenic site Sa (G155E) was detected i

90 e was observed to be higher following ketone substitution in comparison to its removal, indicating th

91 We also generated the parallel substitution in ExaF to produce ExaF D319S and found tha

92 A substitution in FTSJ3 and a splice donor insertion in GH

93 However, the D -> N substitution in IRF3 DPHK is again found in cetaceans su

94 We identified a proline to threonine substitution in Kasalath relative to Nipponbare NOMT as

95 causal roles of one AGS-specific amino acid substitution in mediating cytoprotection by AGS ATP5G1.

96 y all emm12 isolates had a single amino acid substitution in penicillin-binding protein PBP2X that co

97 ither a deletion in NS1 (NS1Delta76-86) or a substitution in polymerase basic 2 protein (PB2-D309N).

98 s, which vary by length and level of halogen substitution in position 4 of the phenyl rings.

99 l hypersensitivity using mice with the Y385F substitution in Ptgs2 (Ptgs2(Y385F) mice), mast cell-def

100 ke most SHP2-activating mutations, the T507K substitution in SHP2 is unique in that it exhibits oncog

101 Importantly, O -> S substitution in squaramide synthons resulted in supramol

102 ew mouse model featuring a single amino acid substitution in the coiled-coil motif of BRCA1.

103 and oligonucleotide to introduce a P663-L663 substitution in the endogenous swine MYO5B (correspondin

104 vity at room temperature than the Pro to Gln substitution in the extracellular segment of S6.

105 agnitude, between hectorite (100% isomorphic substitution in the octahedral layer) and nontronite (10

106 Depending on the substitution in the resulting 1,5-dihydro-2H-pyrrol-2-on

107 The Val to Met substitution in the S4-S5 loop induced a larger increase

108 s, while all RSV B isolates had 2-amino acid substitution in the suptavumab epitope that led to loss

109 edral layer) and nontronite (100% isomorphic substitution in the tetrahedral layer).

110 Additional substitution in the triazolopyridine core disturbed the

111 Here we engineered the spike D614G substitution in the USA-WA1/2020 SARS-CoV-2 strain, and

112 ctional effects of these naturally occurring substitutions in a simplified AgRP scaffold.

113 HE mutations induced successive second-site substitutions in both S and HE.

114 appear to be mutually exclusive and residue substitutions in CdbA regions important for c-di-GMP bin

115 se editors (CBEs) generate C-to-T nucleotide substitutions in genomic target sites without inducing d

116 Furthermore, substitutions in gp120 that increased structural stabili

117 e location of a number of encoded amino acid substitutions in hemagglutinin-esterase fusion (HEF) gly

118 with the emergence of resistance-associated substitutions in mice.

119 r metronidazole, nonsense mutations and R16H substitutions in rdxA correlated with phenotypic resista

120 res a particular investigation of amino acid substitutions in the context of protein structure and fu

121 ariants, DAD2(N242I) and DAD2(F135A), having substitutions in the core alpha/beta hydrolase-fold doma

122 analysis, we identified a pattern of epitope substitutions in the hemagglutinin (HA) of each challeng

123 Notably, the increase of base substitutions in the homologous recombination-deficient

124 bunits, (2) flexibility-inducing polyglycine substitutions in the I-II loop (GGG-alpha(1C)), or (3) i

125 We evaluated the effects of substitutions in the LBD on coactivator, orthosteric, an

126 Substitutions in the main antigenic sites (E153G in Sa,

127 fficient to confer sensitivity to DNMDP, and substitutions in the PDE3A active site abolish compound

128 Upon rescue of 21 mutant viruses, most substitutions in the receptor binding site (RBS) resulte

129 Amino acid substitutions in the thumb subdomain of the RNA-dependen

130 Although nucleotide substitutions in the transcription apparatus accounted f

131 lity assays, we report that point amino acid substitutions in the trigger loop, a flexible element of

132 ential exposures associated with plasticizer substitutions in these products.

133 The mechanism underpinning how substitutions in this position modulate inhibitor effici

134 s without loss of RD3's inhibitory activity, substitutions in two distinct narrow clusters located on

135 codon boxes, differing by at least two-base substitutions, in contrast to Leu and Arg, of which codo

136 ide opportunities to assess how egg-adaptive substitutions influence HA immunogenicity.

137 Selective nitrogen substitution into the ortho positions of the aromatic ri

138 oducing just two post-duplication historical substitutions into the ancestral protein is sufficient t

139 Although the MEIOB N64I substitution is associated with human infertility, the p

140 d to chemically similar but non-native metal substitutions is a long-standing puzzle.

141 anti-influenza drug laninamivir in AIVs with substitutions known to impart resistance to other NAIs.

142 trans isomers and (2) a direct nucleophilic substitution leading to a stereoselective synthesis of t

143 Here, we identify a single amino acid substitution (M159I) that fundamentally alters the therm

144 These surface substitutions markedly reduce oxygen affinity and even c

145 o obtain the latter (aka Tsuji-Trost allylic substitution), metal-catalyzed hydrofunctionalization do

146 Using bioisosteric substitution methods, here, we report the identification

147 phylogenetic tree and incorporate different substitution models, including models of codon selection

148 ds and creation of truncation and amino acid substitution mutants, we provide the first evidence for

149 Genetic studies identify a substitution mutation in gene F12 (T859A, resulting in p

150 For VP7 neutralization epitopes, amino acid substitutions observed at positions T91A/V, S195D and M2

151 Only six substitutions occur at the substrate-binding surface, an

152 [B(12)X(11)](-) reacts by an electrophilic substitution of a proton in an alkane resulting in a B-C

153 equired for ASO binding interactions, and by substitution of abasic nucleotides we identify the posit

154 or, perfunctionalization of this species via substitution of all 12 B-H vertices with alkoxy or benzy

155 Substitution of an A-rich sequence on the 5' side of the

156 Substitution of Arg 289 in Rrp9 to Ala (R289A) specifica

157 that become substantially more dynamic upon substitution of catalytic acid Asp-239 by alanine.

158 Patterned substitution of d-amino acids into the primary sequences

159 f the peptide identified three key residues, substitution of each of which results in ~1000 fold loss

160 literature reports, we found that the single substitution of either 3-hydroxyasparagine (HOAsn) or 3-

161 Substitution of either conserved histidine compromised t

162 of the quinolinoquinoline moiety, while the substitution of electron-withdrawing groups lowers the b

163 An isovalent substitution of Fe(III) for the central Mn(III) ion form

164 LOS HepI glycans extended beyond the lactose substitution of HepI (lactose alone, Gal-lactose, LNnT,

165 Substitution of high-GI foods with minimally processed,

166 Methodology of nucleophilic substitution of hydrogen (S(N)(H)) was first applied for

167 At low temperatures holes introduced via substitution of La by Sr segregate into lines to form bo

168 des for the CysLTR2-L129Q receptor, with the substitution of Leu to Gln at position 129 (3.43).

169 The substitution of moxifloxacin for ethambutol produced pro

170 ring the development of the enantioselective substitution of one fluorine atom to form a stereogenic

171 r in vitro In this study, we discovered that substitution of p.Cys-53 in hGH significantly increased

172 The substitution of paramagnetic chlorine atoms for IAEs pro

173 with a large bandgap of 2.9 eV; the partial substitution of PBDB-T by PTAA reduces the absorption of

174 AlPorF(5)) redox potentials are tuned by the substitution of phenyl (Ph), 3,4,5-trifluorophenyl (PhF(

175 phosphopeptide binding, but rather a tandem substitution of R398A (SH2 position betaD4) and K400A (S

176 The substitution of REG1A with REG1B enhanced the performanc

177 both of which were rescued by a single K214R substitution of RPS3.

178 Substitution of s(2)C(32) for C(32) in the Saccharomyces

179 f different organic acids relevant for the N-substitution of the 3-phenylisoserine side chain of taxo

180 othermal titration calorimetry, we find that substitution of the FLVR arginine R377A does not cause a

181 Substitution of the lactam nitrogen with electronically

182 Specifically, we show that substitution of the N-terminal plug His-221 disrupts bot

183 ylacetophenone, (ii) sequential nucleophilic substitution of the resulting alpha-bromo o-arylacetophe

184 Deletion or substitution of this 'master controller' prevents aggreg

185 Substitution of this lead-contaminated opium by Opioid M

186 By contrast, substitution of tungsten with tellurium induces redox st

187 Breads were produced with partial substitution of wheat flour by corn (CF), green banana (

188 y that stems from the presence of isomorphic substitutions of Fe(2+) by Fe(3+) in its layers.

189 l sites of phosphorylation, we show that Ala substitutions of Ser-561 and Ser-641/Thr-642 recapitulat

190 Distal H-bonding substitutions of the N(6)-(2-phenylethyl) moiety particu

191 o hIL-23R and found that the combined site 3 substitutions of W156A and L160E, which become buried at

192 tely predicting the quantitative impact of a substitution on a protein's molecular function would be

193 sites for compositional variation: elemental substitution on both the metal (M) and carbon/nitrogen (

194 rated thermally or photochemically underwent substitution on readily prepared dialkyl, diaryl, and di

195 Radical substitution on tetrasulfides is demonstrated to be a hi

196 Benzylamine compounds with methyl group substitution on the charged amine or with electron-donat

197 Optimal substitution on the PP scaffold included 2-pyridyl ether

198 abled us to measure the effect of individual substitutions on specificity in hundreds of genetic back

199 d a small series of compounds with either no substitutions on the TPE phenyl ring containing the anti

200 The three detected SREBF1 mutations caused substitution or deletion of residues 527, 528, and 530,

201 of NHE6 expression, but how subtler missense substitutions or nonsense mutations that partially trunc

202 sen with different proportions of isomorphic substitutions (origin of clay charge) located in octahed

203 ive site, we observed that subtle amino acid substitutions outside the active site in the ancestor CY

204 Conditions that favor the tele-substitution pathway were identified: the use of increas

205 rred at given sites and identified intuitive substitution pathways that can be explored for compound

206 The relative stereochemistry and isomeric substitution pattern of organic molecules is typically d

207 d as the optimal catalyst depending upon the substitution pattern within the substrate.

208 Dependent on the exact substitution pattern, the absorption onsets of the new m

209 istinct features: aglycon, glycan, and amine substitution pattern.

210 he FDA through 2019 and show that only a few substitution patterns (1-, 1,2-, 1,4-, and 1,2,4-) preva

211 A systematic analysis using monomer substitution patterns established that sequence-defined

212 Here, we analyze the substitution patterns of benzenoid rings in small molecu

213 of the quaternary center, allowing different substitution patterns on the aromatic ring and the alken

214 explored, with piperidines bearing multiple substitution patterns providing the arylated products in

215 nd protection/deprotection of the TFP group, substitution patterns that do not conform to classical S

216 ives, one of the most challenging anthracene substitution patterns to obtain, is presented.

217 We explore a number of substitution patterns, such as 1,2-dimethoxybenzene, nap

218 gree of sequence conservation (20 nucleotide substitutions per kb).

219 Single base substitutions predominated including frequent A:A (templ

220 r C-H borylation, (i) electrophilic aromatic substitution (prevalent with B-X electrophiles); (ii) si

221 We screened viruses with NA substitutions previously found during OS and ZAN selecti

222 s time-reversibility and stationarity of the substitution process.

223 of nonconserved positions for which various substitutions produced progressive functional changes; w

224 Mechanistically GLP-2 substitution promoted regeneration of PCs and ISCs, whic

225 d degradation upon DNA damage, whereas S429A substitution protects MDM2 from auto-degradation.

226 eact with cysteine via nucleophilic aromatic substitution, providing a mechanistically selective and

227 ease deficiency with a polymerisation domain substitution raised the organelle DNA polymerase error r

228 The highest substitution rate was lineage-specific within the araphi

229 tle evidence of diversifying selection, with substitution rates comparable across structural versus n

230 e show that neutral evolution and nucleotide substitution rates up to forty-fold faster than observed

231 n an enantioselective intramolecular allylic substitution reaction catalyzed by a combination of pall

232 ical and to estimate the rate of the radical substitution reaction involved in the methyl transfer; a

233 age of CS(2)/aromatization/nucleophilic acyl substitution reaction of 2-(4-oxo-2-thioxothiazolidin-5-

234 s, as its acetate 4, discovered to undergo a substitution reaction with cysteine derivatives.

235 an effective LG for activating nucleophilic substitution reactions on tyrosine sites of proteins.

236 idine products undergo nucleophilic aromatic substitution reactions with oxygen and carbon nucleophil

237 was demonstrated via highly enantiospecific substitution reactions with suitably reactive nucleophil

238 We found that R55/R57 substitutions reduced recognition of a UUG start codon a

239 Here, we show that the E344Q substitution reduces KPNA7 binding to nuclear localizati

240 ted that the frequently recurring STK19 D89N substitution represents a gain-of-function change, allow

241 converts unresolved or compound errors into substitutions, restoring synchronization for correction

242 Both T5A and T7A substitutions result in functional carboxylases that are

243 None of the tested substitutions resulted in a clear step toward a human-ad

244 ing to a single atom at the site of isotopic substitution, reveals a remarkable result for both impli

245 remote regioselective electrophilic aromatic substitution (S(E)Ar) reactions that are enabled via the

246 etition between the bimolecular nucleophilic substitution (S(N)2) and base-induced elimination (E2) p

247 biological thiols via nucleophilic aromatic substitution (S(N)Ar).

248 Functional studies were performed for all 20 substitutions (S267X) with three substrates (TCA, estron

249 effects on overall transport, and individual substitutions showed varied effects on transport kinetic

250 Moreover, Bi substitution significantly tunes the Seebeck coefficient

251 Substitution site-specific replacement and network analy

252 how long-term experiments and space-for-time substitution sites can serve as sources of knowledge and

253 ular hydrogen bonding formed by 1,10-diamide substitution stabilizes Boat, spiking the temperature at

254 or the first time that the amide-to-triazole substitution strategy offers new opportunities in drug d

255 groups that are susceptible to nucleophilic substitution such as alkyl halides.

256 cines boosted titers to HA with egg-adaptive substitutions, suggesting boosting from past antigens or

257 of the exact location of the phosphomimetic substitutions, suggesting that modulation of PrLD phosph

258 se in stability with as few as 18 amino acid substitutions suggests that this bovinization process is

259 s are distinguished depending on whether the substitution takes place from their neutral forms, from

260 ed Word Recall Test (DWRT), the Digit-Symbol Substitution Test (DSST), and the Word Fluency Test (WFT

261 Cognitive Assessment (MoCA) and Digit Symbol Substitution Test (DSST).

262 We identify a historical substitution that has pleiotropic effects on S100A9 proi

263 d in lignin biosynthesis, showed a base-pair substitution that is associated with decreased PD.

264 or and S. vitellina, including an amino acid substitution that is unique to warblers but otherwise hi

265 A synonymous substitution that results in exon eight skipping in most

266 Three GmVTL1a amino acid substitutions that block nitrogen fixation in Ljsen1 pla

267 d spike designs and identified 26 individual substitutions that increased protein yields and stabilit

268 nding domain, we identified several sequence substitutions that together improve binding to Ral prote

269 ctive synthetic auxin herbicide, using alien substitution (the S genome of Aegilops searsii) and aneu

270 th unemployment, Gini coefficient, or opioid substitution therapy coverage provision at the country l

271 on shows that it involves an initial allylic substitution to form a new Michael acceptor, followed by

272 Substitution to helix-enhancing alanine at either of the

273 A simple fluorine substitution to phenethylammonium for the organic cation

274 d constant heavy domain 3 heterodimerization substitutions to create TTR-mediated conatumumab tetrame

275 mutations ranged from single amino acid (aa) substitutions to frameshift mutations causing premature

276 erspecies chimeras and individual amino acid substitutions, to identify regions required for channel

277 ar initial biotransformation reactions, with substitution-type reactions maintaining Arrhenius-type b

278 blueprint for affecting redox-neutral S(N)1 substitutions under mild conditions.

279 tive homology model containing 61 amino acid substitutions unique to the indirect flight muscle isofo

280 sequence-based methods to detect nucleotide substitution variants have error rates (about 10-3) that

281 Erwinia chrysanthemi ASNase (Erwinia) substitution was approved in 2011 for allergic reactions

282 The highest degree of substitution was found in FHIA 21 (0.020) starch with 3%

283 Frequency of phenotypically resistant substitutions was higher with regimens containing lower

284 Through a facile Gly to Pro substitution, we have altered backbone dynamics, complet

285 determine the fitness impact of the I38T/F/M substitutions, we generated recombinant A/California/04/

286 randomized cohort, glycoprotein 120 (gp120) substitutions were found in 20 of 47 patients (43%) with

287 wer for the Trp variants, but effects of the substitutions were moderate and sometimes negligible.

288 the ettringite crystal structure via sulfate substitution when synthesized by aqueous precipitation m

289 more detrimental to activity than the double substitution where both HOAsn and MeOAsp are replaced wi

290 gas phase reactivity of Al(3)O(4)(+) upon Fe-substitution, which is correctly predicted by multirefer

291 morphic ventricular tachycardia-causing N53I substitution, which resides in the N-terminal domain (N-

292 ii) fast exchange of monomers by competitive substitution, which together enable rapid kinetics.

293 tibacterial activity enhancement via halogen substitutions, which afforded new anti-C. difficile agen

294 81K-N3(R292K)) or Q136K (ma81K-N8(Q136K)) NA substitutions, which impart in vitro susceptibility only

295 Patients with Erwinia substitution who completed subsequent courses were not a

296 of the reactant ketone from the feed, or its substitution with a similarly structured species.

297 d by means of solvent solution and by strand substitution with DNA and unmodified PNA.

298 Interestingly, substitution with SR-17018 in morphine-tolerant mice res

299 e constructed several Cyt1Aa variants having substitutions with a single cysteine residue in differen

300 Hence, we introduced additional hIL-23p19 substitutions within its binding interface to hIL-23R an

301 ty of the surface-exposed residues tolerated substitutions without loss of RD3's inhibitory activity,

302 ype-1 (HIV-1) with HBV-associated amino acid substitutions Y115F/F116Y/Q151M in its RT (HIV(Y115F/F11