ライフサイエンスコーパス: subtle

1 S56 phosphorylation, its regulatory role is subtle.

2 e severity of the mutations must be somewhat subtle.

3 Variations in patch spatial density were subtle across different visual eccentricity representati

4 und able to follow human pointing, including subtle actions in which the contralateral hand is used,

5 g which AD class 3 -also known as limited or subtle AD- is the less recognised.

6 onses are likely a form of sensory tuning: a subtle adjustment of the eyes to optimize their properti

7 generated during this study demonstrates the subtle alterations of morphology characterized by reduce

8 uricemia and metabolic alterations, but only subtle alterations of renal urate excretion and ABCG2 ab

9 y occur as transient blurred vision and with subtle alterations of the fundus.

10 ty remained generally preserved with minimal subtle alterations.

11 ne in a closed active site, we observed that subtle amino acid substitutions outside the active site

12 n pathology is not characteristic of autism, subtle anatomical and functional differences have been o

13 in that low-to-moderate neurotoxicity can be subtle and difficult to measure.

14 at evolution in chronic cold has led to both subtle and distinctive changes in the cellular apparatus

15 imaging tools have aided in diagnosing even subtle and early RAH with high sensitivity using Infrare

16 operative response are capable of converting subtle and gradual biological variations into robust out

17 cell types where morphological responses are subtle and heterogeneous.

18 ts, whereas tumor-specific abnormalities are subtle and inconsistently present.

19 These subtle and pervasive effects demonstrate additional comp

20 ic ordinal scoring, quantitative IA detected subtle and progressive features of early and terminal EV

21 Hundreds of SV-gene pairs exhibit subtle and significant expression changes, which could b

22 s in quiescent cells to analyze responses to subtle and strong perturbation of microtubules.

23 cattering can be used to noninvasively probe subtle and transient dynamics.

24 the initial motor symptoms are usually very subtle and, as a result, patients seek medical assistanc

25 The measurements also reveal a subtle anomaly from 0 to 70 K in all samples that does n

26 metal's redox properties, demonstrating that subtle architectural changes can dramatically alter meta

27 ers to clathrate science in elucidating some subtle aspects of the model and to intrigue clathrate ex

28 We propose that subtle asymptomatic alterations in lymphatic vascular fu

29 Complex crystal structures with subtle atomic-scale details are now routinely solved usi

30 ts lack the sensitivity needed for detecting subtle balance impairments associated with mild traumati

31 are used to construct polygenic scores, even subtle biases can cumulatively lead to large errors.

32 etic capacity loss during discharge but as a subtle bimodal compositional distribution early in charg

33 cy as an important diagnostic tool to detect subtle brain injury specifically in mild TBI patients.

34 ne-based event detection, we demonstrate the subtle build-up of aberrant microdomain Ca(2+) transient

35 In order to capture subtle but biologically significant differences in trans

36 , multivariate statistical analyses revealed subtle but consistent and significant variations with de

37 ated vacuoles and lipid bodies and displayed subtle but consistent differences in lipid composition.

38 These findings reveal the subtle but important role of molecular structure includi

39 chanism of SCN8A-related epilepsy and reveal subtle but potentially important distinction of function

40 enes dominates expression across cell types, subtle but significant differences in other genes can be

41 We identify subtle but significant differences that correlate with e

42 Subtle but significant morphological changes result from

43 influence a chemical exchange reaction in a subtle but significant way.

44 ported agar plate experiment, again owing to subtle but very significant differences in methodology.

45 Subtle, but coordinated, gene expression changes may be

46 nts in lymphatic smooth muscle revealed only subtle, but not significant, differences in the resting

47 ethal phenotypes that prevent elucidation of subtle, but physiologically important, metabolic consequ

48 are characteristic for a given subgroup play subtle, but pivotal, roles in guaranteeing that the corr

49 structure and dynamics that are surprisingly subtle, but still sufficient to produce a large effect o

50 nd harmonized multisite DTI study, we showed subtle, but widespread differences in WM microstructure

51 We observed subtle, but widespread, lower fractional anisotropy (FA)

52 ed results provide interesting insights into subtle causality issues underlying the simultaneous exci

53 ty of MMP 13 versus MMP-2 can be achieved by subtle chain contraction in a BITE-modified inhibitor.

54 Altogether, the results show that subtle changes can determine for an initially formed met

55 sufficiency-related RP, but rather that more subtle changes can lead to mutant proteins stable enough

56 is the ability of the new method to capture subtle changes for individual patients before and after

57 creases as an indicator for learning, making subtle changes in activity patterns across weeks the mos

58 that the BER DNA ligases are compromised by subtle changes in all 12 possible noncanonical base pair

59 nd dogs and allows us to detect diet-induced subtle changes in ApoAI turnover in mice.

60 To determine whether more-subtle changes in bacterial populations impact viral rep

61 To improve our understanding of how subtle changes in bilayer thickness alter the gramicidin

62 PulseCam can detect subtle changes in blood perfusion below the skin with at

63 Therefore, we suggest that subtle changes in chromatin accessibility are a prerequi

64 We show that, upon subtle changes in crosslinking patterns, composites can

65 communicate occupancy to the active site via subtle changes in dynamics, enabling exquisite fine-tuni

66 rdiac cycles, our model can rapidly identify subtle changes in ejection fraction, is more reproducibl

67 t contain sensory cells capable of detecting subtle changes in electric fields (Figure 1B) [3,4].

68 enging: crystallization can be influenced by subtle changes in environment, such as temperature and m

69 enriched sequences, extreme sensitivities to subtle changes in environmental conditions, and well-kno

70 Additionally, scHOT identifies subtle changes in gene-gene correlations across space us

71 t cell lines revealed how cryo-EM can detect subtle changes in glycan occupancy, composition, and dyn

72 t the initial epsilon-cleavage sites of C99, subtle changes in hinge flexibility were identified that

73 te did not correlate significantly with more subtle changes in indirect calorimetry due to walking wi

74 uum between large conformational changes and subtle changes in internal dynamics.

75 The development of biosensors to track subtle changes in intracellular parameters provides inva

76 Even preserved EF patients showed subtle changes in myocardial deformation, suggesting sub

77 minally similar particles and highlights how subtle changes in particle form can greatly impact elect

78 pproach provides critical information on how subtle changes in protein primary sequence trigger cross

79 Thus, subtle changes in simple activator-inhibitor systems are

80 st-translational modifications can result in subtle changes in structural and dynamic properties, whi

81 brain is particularly plastic, whereby even subtle changes in structure and function produced by in

82 R interval and QRS duration, suggesting that subtle changes in TBX3 expression affect atrioventricula

83 nce the reactivity control is shifted toward subtle changes in the base.

84 Chemical sensing aims to detect subtle changes in the chemical environment by transformi

85 Structural studies reveal that only subtle changes in the ligand binding domain, often ident

86 rements are sensitive probes that can detect subtle changes in the local Seebeck coefficient of gold

87 (+) (Nav) channelopathies can be ascribed to subtle changes in the Nav macromolecular complex.

88 X-ray crystallography studies identify subtle changes in the pose of binding to beta-tubulin th

89 'pseudotime' offers the potential to unpick subtle changes in variability and covariation among key

90 r data collected over time may help identify subtle changes indicating an infection, such as in patie

91 In order to detect the subtle changes of reconstruction of SPA and SA, a few lo

92 macologic activities exhibited by them after subtle changes to their appended substituents, are becom

93 There were also subtle changes which were attributed to prior infarction

94 Locating these subtle changes will be a challenging task for the future

95 These subtle changes, whose functional relevance remains uncer

96 orientation of the hydroxyl groups or harbor subtle chemical modifications.

97 We showed that subtle chromatin binding changes in differentiated cells

98 ts appear, increasing evidence suggests that subtle cognitive changes may begin early, potentially be

99 A subtle competition between hydrogen, halogen, and carbon

100 Importantly, the effect induced by subtle compositional changes on intermetallic energy tra

101 ts movements of the fingers, and RdRPs use a subtle conformational change within the palm domain to c

102 CIU detects subtle conformational changes of proteins and emerges as

103 Subtle conformational effects seen for singly charged me

104 ysics to cosmology including an intimate but subtle connection in magnetic systems, for example Mn(1-

105 l response to finer spatial details and more subtle contrasts at only higher spatial frequencies in t

106 rium architectures, however, requires a more subtle control over the thermodynamics and kinetics of r

107 frustrated magnet, with its spins exhibiting subtle correlations, albeit in the absence of a long-ran

108 More subtle cross-genotype variant contamination can be used

109 uncertainty, such as when the resource is in subtle decline and intragroup communication sparse.

110 pmental delays and uncoordinated movement to subtle deficits in sensory and learning behaviors.

111 first confirm that this task is sensitive to subtle deterioration in memory performance across ageing

112 ified more differential splicing events with subtle difference across cell types compared to Census a

113 d with Alzheimer's disease, highlighting the subtle difference between functional and dysfunctional a

114 elical bicarbazole monoradicals along with a subtle difference of electronic coupling between the two

115 The study findings suggest robust but subtle differences across different age groups among ADH

116 Therefore, subtle differences and complementarity will be highlight

117 Differentiation of subtle differences between cultivars of the rose flower

118 n be used to investigate situations in which subtle differences between ligands may lead to diverse c

119 gmentation of THF-doped DOM in APPI resolved subtle differences between riverine DOM that was absent

120 ony level variation in infection levels, and subtle differences between the microbiota of colonies wi

121 trucCompare captures both the large and more subtle differences found between structures, enabling vi

122 oligosaccharide degradation suggest that the subtle differences in amino-acid sequence within the sub

123 However, subtle differences in ASD profiles distinguish CNV group

124 chromatin accessibility provides a basis for subtle differences in binding specificity and affinity t

125 On the posterior region, subtle differences in body shape and kinematics allow tr

126 species, which may play a role in modulating subtle differences in emotional processing and species-t

127 the simulation analysis can distinguish the subtle differences in exchange due to mutation.

128 lds promise as a clinical tool for capturing subtle differences in heterogeneity between malignant, b

129 Subtle differences in life histories, thermal requiremen

130 d in their ability to describe the impact of subtle differences in molecular structure on the overall

131 Our findings demonstrate that subtle differences in neuronal projection patterns can h

132 for sophisticated models in order to explain subtle differences in release, such as those observed at

133 be unprecedentedly highly sensitive to even subtle differences in the inductor structure (i.e., O vs

134 hanges in free-carrier concentrations and to subtle differences in the interlayer displacement or spa

135 Despite high sequence divergence, and subtle differences in the models, E2 from different stra

136 itivity of tunneling charge-transport to the subtle differences in the overall composition of SAMs an

137 While each surrogate virus exhibited subtle differences in the sensitivity with which neutral

138 This study illustrates how subtle differences in these novel amino GABA bioisostere

139 ly modern humans, with a particular focus on subtle differences in thumb morphology and how this may

140 eferences of human and mouse DNMT3B revealed subtle differences suggesting a co-evolution of flanking

141 rated development and others indicating only subtle differences vs. modern humans.

142 mily abundance on individual proteins showed subtle differences, providing an additional level of mol

143 reness about the fact that implicit bias and subtle discrimination are widespread, our findings spotl

144 We further demonstrate that subtle disequilibria also affect Delta(47) in biogenic c

145 o differences in conversion rate and implies subtle distinctions in the final polymer structure.

146 the characteristics of the disease with very subtle dopaminergic neuron degeneration.

147 erivatives with fast elongation rates show a subtle downstream shift in poly(A) sites.

148 eration and offer an explanation as to why a subtle dysfunction of BCCIP can be tumorigenic but a com

149 Here we show that subtle economic status cues in clothes affect perceived

150 Nevertheless, subtle edits such as single base changes or small deleti

151 be recoverable from relative data, but more subtle effects are challenging to identify.

152 phenotypes may be due, at least in part, to subtle effects of genetic background.

153 The subtle effects of symmetric and asymmetric methylation c

154 pact survival of fish larvae in situ through subtle effects on larval behavior.

155 More subtle effects on membrane function mediated via changes

156 indicates that these differences are due to subtle effects on PA function.

157 onstrate that the miR-23-27-24 clusters have subtle effects on skeletal muscle development and endura

158 the interaction between contextual cues and subtle emotional faces, such that participants' ratings

159 ant) on emotional attribution (the rating of subtle emotional faces: fearful, neutral, or happy).

160 ndreds of adaptive yeast mutants responds to subtle environmental shifts.

161 inability to record interviews, and possible subtle errors in translation.

162 es allows to obtain a precise picture of the subtle events directing the encapsulation and is thus a

163 opulations, and that the E1297 variant shows subtle evidence of positive selection specifically withi

164 iour in skates in response to EMF and a more subtle exploratory response in lobsters.

165 mental delay and/or intellectual disability, subtle facial dysmorphisms, behavioral and psychiatric p

166 Covert facial mimicry involves subtle facial muscle activation in observers when they p

167 Subtle features of common language can imply to young ch

168 Thus, subtle features of language shape children's beliefs and

169 and speech and shows that language acts as a subtle filter through which we understand and interact w

170 cess, but the clinical significance of these subtle findings is not known.

171 be robust enough and here, we show that the subtle FMI of early PD patients can be effectively estim

172 Remote and unobtrusive screening of subtle FMI via natural smartphone usage, may assist in c

173 st, disease risk increase appears to be less subtle for disease-predisposing environmental insults.

174 Exposure to even subtle forms of misleading information can significantly

175 More subtle forms of multiple testing are not as widely recog

176 ulus was more often sensitive to the sound's subtle frequency variation compared with spiking during

177 ost mutations have no impact, some result in subtle functional differences that ultimately manifest i

178 5b prevented subtle gait deficits in WT alphaS mice and the PD-like r

179 However, we have yet to know whether subtle genetic differences within a population can be di

180 ch a successful way of creating progeny with subtle genetic variations that the vast majority of euka

181 wed an 80% decrease, the mice displayed only subtle impairment in their motor functions.

182 er the first eight postoperative weeks, with subtle improvement afterwards.

183 may induce behavioral disturbances that are subtle in nature following early repeated exposures to a

184 These outcomes might be subtle in terms of cognition but appear to persist into

185 paramagnetic to photonic glass phase is more subtle in that the Parisi overlap function broadens inst

186 expand and decline, generally showing only a subtle increase in VAF (mean, 0.56%) over the course of

187 nd molecular analysis are not performed, the subtle infiltrate may be easily overlooked.

188 Signs of subtle inflammation were marked with cardiorenal, endoth

189 It was found that ethanol has a subtle inhibitory effect on the binding of hydrophobic c

190 ult to observe directly in live cells, these subtle interactions can be discerned by their impact on

191 can reduce loop formation times because of a subtle interplay between the nucleosome size and the mea

192 spite having been studied for centuries, the subtle interplay between topology and mechanics in elast

193 Subtle interstitial changes in the lung parenchyma of sm

194 Knockdown of VASH1 conferred subtle kinetic improvements in nonfailing cardiomyocytes

195 ns, and even highly trained experts may miss subtle life-threatening findings.

196 whole, but they are inaccurate in detecting subtle local changes of reconstruction.

197 In real paramagnets, there is always a subtle many-body contribution to the system's energy, wh

198 egimes (shear and inertial) which can expose subtle mechanical properties arising from subcellular co

199 ction of fundal interneurons (WIFI) underpin subtle middle-retinal opacification with periarterial sp

200 tional mouse mutants for these genes display subtle migratory defects in the abdominal muscles of the

201 Our study demonstrates that a subtle modification of TRPV1 in different species global

202 Through subtle modification to a steroidal backbone, a recently

203 These molecular insights suggest that subtle modifications to the catalyst framework could be

204 ical molecules whose complicated structures, subtle modifications, and large sizes often impede molec

205 s with sufficient sensitivity to discern the subtle molecular differences among all twenty amino acid

206 omised, but their motor neurons exhibit only subtle morphological and electrophysiological changes th

207 at 3D refractive index tomograms can capture subtle morphological differences among the parental, cir

208 matically derived image features can capture subtle morphological differences between TFE3-RCC and cc

209 Our data show evidence of subtle motor and non-motor signs of Parkinson's disease

210 inical complementary tool aiming to identify subtle motor behaviors that might reflect residual cogni

211 to use in machine-learning models to capture subtle multi-parametric perfusion properties, including

212 A novel FeLV variant arose from a subtle mutation of FeLV-A Env, which altered the specifi

213 at birth, and the full impact of these more subtle neuropathologies has yet to be determined.

214 zed reactions is an ongoing challenge due to subtle, noncovalent interactions that drive selectivity.

215 This technique uses subtle nonverbal and verbal conversational primes to inf

216 atforms are sufficiently accurate to resolve subtle nucleotide substitutions (but not insertions/dele

217 An appreciation of these somewhat subtle paradigms can inform efforts to compare the resul

218 oke syndrome known as lacunar stroke or more subtle pathological alterations of the brain parenchyma,

219 Here we identify regimes where more subtle, patterned surfaces enable saddle-splay effects t

220 s highly powered collaborative effort showed subtle patterns of age-related structural brain abnormal

221 sequencing costs, and the ability to resolve subtle patterns of population genetic structure.

222 ng contributions generally interplay in more subtle patterns, only giving the impression of a clear-c

223 A subtle perturbation of the edge-to-face conformation by

224 is widely promoted for its ability to detect subtle perturbations in protein structure, but such pert

225 d that these phenotypes were associated with subtle perturbations in the photorespiratory cycle of HP

226 ionally inactive forms may be accessible via subtle perturbations of Ras' orientational preferences a

227 res, other substitutions will likely be more subtle, perturbing predominantly the protein folding pat

228 ve results due to poor understanding of this subtle phenomenon.

229 tical aspects of embryogenesis, for example, subtle phenotypic differences or gene expression dynamic

230 erol-rich membrane by CDCs is a surprisingly subtle process that takes place at the interface between

231 nd over 1,100 children) to test if targeting subtle properties of language can increase science engag

232 ith 117 experimental variables to assess how subtle protein sequence variations drive the molecular t

233 ial B-class dimerization was associated with subtle, quantitative differences in stamen shape.

234 eral magnetic measurements, we show that the subtle random potential of frozen BCO Brownian rotors su

235 Given the strong cancer susceptibility to subtle reductions in PTEN, the ability of PRL2 to down-r

236 genome-wide chromatin accessibility through subtle refinement of H2A.Z patterns, providing a means t

237 and read intentions via explicit signals and subtle reflections of arousal visible in the face.

238 To examine these potentially subtle relationships, we amassed a large multi-site data

239 ing of dynamic changes in sleep posture, and subtle respiration and ballistocardiograph (BCG) monitor

240 E2 glycosylation on S binding and revealed a subtle sensitivity with hypersialylated or oligomannose-

241 , shape complementary interfaces to read out subtle sequence differences for subtype-specific antagon

242 There are subtle sex-related differences in the predictive value o

243 Subtle shadings of LacZ signal, jointly with pan-DLX imm

244 These findings illustrate how a subtle shift in language establishes a powerful sense of

245 its rugged free-energy landscape, with very subtle shifts in the populations of a small number of st

246 Subtle shifts in the relative abundance of 14 bacterial

247 iet period provides an opportunity to detect subtle signals from subsurface seismic sources that woul

248 rained at lower dimensionalities, while more subtle signals such as pathway activity are best identif

249 0 mg, and topotecan 2 mg) and noting certain subtle signs of early regression can help to minimize un

250 Additionally, we explore whether subtle, societally common reductions in sleep trigger el

251 ent effects and will shed light on extremely subtle solvation phenomena.

252 highlight SEER's enhancement of specific and subtle spectral differences, providing a fast, intuitive

253 nal responses and an enhanced sensitivity to subtle stimuli.

254 ision formation while subjects discriminated subtle stimulus feature changes whose timing relative to

255 re consistent with prior studies, suggesting subtle strain differences.

256 Subtle structural changes exerted significant influence,

257 tool for studying these problems, revealing subtle structural changes in proteins not accessible by

258 g six rings only, illustrating the impact of subtle structural changes on spin-density distribution.

259 lective binding sites for discriminating the subtle structural difference of isomers are urgently nee

260 rides and two isomeric tetrasaccharides with subtle structural differences are distinguished rapidly

261 The subtle structural differences between digenite and tetra

262 -resolution tools are needed to observe more subtle structural differences between particles of diffe

263 able crystal structures of SK1 suggests that subtle structural differences exist in the foot of the l

264 d the power of this method by (1) extracting subtle structural differences from visually indistinguis

265 This analysis reveals how subtle structural differences in the cage framework affe

266 We explain how subtle structural differences, mostly depending on the s

267 of Ub polymer lengths and linkages and their subtle structural differences.

268 Subtle structural discrepancies on mechanosensitive chan

269 Subtle structural features in bacterial lipids such as u

270 nship study of haloperidol and revealed that subtle structural modifications dramatically change bind

271 By including subtle structural perturbations in individual metasurfac

272 nization by the preformed AB ring system and subtle substituent effects.

273 ommunication during learned movement is more subtle than expected, with changes in firing rates possi

274 mple sizes, some of these mechanisms were so subtle that they were overlooked in our initial modeling

275 issue characterization, but fails to capture subtle thermal properties in heterogeneous systems.

276 These findings demonstrate that subtle timing cues fundamentally shape the experience of

277 ng (qMRI) techniques allow the assessment of subtle tissue changes not only of structure and morpholo

278 Subtle tissue deformations caused by mass-effect in Glio

279 These differences range from subtle to overt, suggesting that isolated epibulbar lacr

280 hat polymorphisms in rocA result in either a subtle transcriptome change, causing a wild-type-like vi

281 Subtle tuning of the laser pulse shape caused an 80% inc

282 We reveal that mAb 3D11 can accommodate all subtle variances of the PbCSP repeating motifs, and, upo

283 uired for avian functional traits to predict subtle variation in trophic niches and provide a global

284 is important for the efficient detection of subtle variations among reconstructed macromolecular str

285 In addition, numerous subtle variations in chemoarchitecture between the two s

286 Here, we uncover tuning to subtle variations in frequency trajectories in auditory

287 same stability region of a Pourbaix diagram, subtle variations in pH and redox potential can redirect

288 Our studies demonstrate that subtle variations in the structure of an abiotic energy

289 by an ATXN1 polyglutamine protein, although subtle variations in WT AXTN1 levels also lead to ataxia

290 tion, mucosal biopsies allowed detecting the subtle variations of local microbial communities.

291 However, detecting subtle variations of mobility between different chromati

292 efore, analytical techniques that can detect subtle variations without interfering with native biomol

293 easurement of mechano-acoustic signals, from subtle vibrations of the skin at accelerations of around

294 ry variants of genes that contribute in more subtle ways to the disorder.

295 lso modify the electronic properties in more subtle ways when electron motion becomes governed by tim

296 fluid (3)He the role of bound states is more subtle: when a macroscopic object moves in the superflui

297 osition of patients with FGIDs are generally subtle, whereas changes in microbial function, reflected

298 culoskeletal tensioning of the body, such as subtle wrist movements.

299 ohol use during pregnancy is associated with subtle yet significant psychological and behavioral effe

300 Here we induce subtle zinc perturbations and track asynchronously cycli