ライフサイエンスコーパス: subvert

1 Thus, reduced BMPR2 can subvert a stress granule response, heighten GM-CSF mRNA

2 om the earliest stages of tumor inception to subvert adaptive T cell immunity.

3 The mechanism by which B. melitensis subverts adaptive immunological memory is poorly underst

4 Genetically unrelated viruses can subvert analogous subcellular mechanisms and use similar

5 We review the strategies that EBV uses to subvert and evade host immunity and discuss the implicat

6 sive myeloid-derived suppressor cells (MDSC) subvert antitumor immunity and limit the efficacy of chi

7 that induce NKG2D ligands on myeloid cells, subverting antitumor immune responses.

8 onism by specific pathogenic flaviviruses to subvert antiviral immune responses in human DCs.

9 epatocytes exacerbates Tfr cell responses to subvert antiviral immunity.

10 Elucidating the mechanisms by which CHIKV subverts antiviral immunity to establish and maintain a

11 rial infection modulates miRNA expression to subvert any innate immune response.

12 sites with AP1 motifs, suggesting that BCL6 subverts AP1 activity.

13 hagocytic destruction, some viruses can also subvert autophagy for their own benefit.

14 IAV therefore subverts autophagy by mimicking a host short linear prot

15 T(reg) cells subvert beneficial anti-tumor immunity by modulating inh

16 TNFalpha-mediated suppression of BMPR-II subverts BMP signalling, leading to BMP6-mediated PASMC

17 rate how the cellular death machinery can be subverted by an invasive pathogen to ensure bacterial co

18 icking mechanism of STING regulation that is subverted by bacterial pathogens and is deregulated in h

19 reparative and homeostatic functions can be subverted by chronic insults, resulting in a causal asso

20 Peptide inhibition of F may be subverted by continued engagement of receptor by H, a fi

21 an important regulator of polarity, which is subverted by HCV in epithelial cells.

22 the enzyme that adds ac4C to RNAs, have been subverted by human immunodeficiency virus 1 (HIV-1) to i

23 Ps and identify an antiviral pathway that is subverted by JUNV.IMPORTANCE Arenaviruses are important

24 e inert structures and explains why G3BP1 is subverted by many viruses to promote a productive infect

25 The function of the MALT1 gene is subverted by oncogenic chimeric fusions arising from the

26 tracellular organisms, and often found to be subverted by pathogens through use of host anti-apoptoti

27 n, and a mechanistic account of host factors subverted by the virus in its natural target cell.

28 Among the many cell types subverted by transformed epithelial cells, fibroblasts a

29 ruitment and activation of IRF-3 that can be subverted by viral proteins to evade innate immune respo

30 To identify the host factors subverted by viruses, high-throughput genomics and globa

31 mplicated in myriad human cancers and can be subverted by viruses.

32 uggests that aberrant WNT signaling may also subvert cancer immunosurveillance, hence promoting immun

33 1 and other primate immunodeficiency viruses subvert cell cycle regulatory mechanisms to achieve thes

34 idence that primate immunodeficiency viruses subvert cell cycle regulatory mechanisms to enhance repl

35 dria is a powerful strategy for pathogens to subvert cell physiology and establish infection.

36 coli, Salmonella, Yersinia, and Shigella, to subvert cell signaling and host responses.

37 s of the mechanisms by which C. gattii might subvert cell-mediated immunity, we found that C. gattii

38 rs into the cytosol of mammalian host cells, subverting cell signaling and facilitating the onset of

39 oligomers as secondary toxins to efficiently subvert cellular functions of actin while functioning at

40 uring infection, positive-strand RNA viruses subvert cellular machinery involved in RNA metabolism to

41 Many viruses encode or subvert cellular microRNAs (miRNAs) to aid in their gene

42 lex interplay between viral determinants and subverted cellular membrane homeostasis in biogenesis an

43 cocci within infected lymph nodes resist and subvert clearance by phagocytes, enabling replication th

44 in, providing an unparalleled opportunity to subvert CMV antigens as tumor-specific immunotherapy tar

45 role for NspA in enabling N. gonorrhoeae to subvert complement despite LOS phase variation.

46 gonorrhea, has evolved several mechanisms to subvert complement, including binding of the complement

47 The tobacco industry's documented history of subverting control efforts required innovative approache

48 ed a remarkable array of tactics for rapidly subverting control over and dominating cellular regulato

49 MET regulation via the juxtamembrane domain subverts core MET receptor functions that regulate osteo

50 it is unclear whether poxviruses dedicatedly subvert costimulation during infection.

51 Adenovirus E4-ORF3 and E1B-55K converge in subverting critical overlapping cellular pathways to fac

52 HIV-1 is thought to subvert CTLs while preserving NK cell inhibition by Nef-

53 gammaherpesvirus-specific tegument protein, subverts cytosolic DNA sensing by directly inhibiting cG

54 Thus, MV subverts DC-SIGN to control RLR activation and escape an

55 of host proteins, alter auxin signaling, and subvert defense signaling and immune responses.

56 To subvert defense, they may mimic host proteins at the seq

57 (SGs) and modulate viral gene expression by subverting different proteins involved in the stress gra

58 enerated by pathogens, is both activated and subverted during human gammaherpesvirus infection in cul

59 This balance, however, is subverted during infection, injury or autoimmune respons

60 The osteogenic default pathway may be subverted during pathological conditions, leading to ske

61 with many physiologic processes that become subverted during tumorigenesis, the chaperoning activity

62 d explores underappreciated factors that can subvert efforts to purposefully alter cytokine biodistri

63 r inflammation that Clostridioides difficile subverts, enabling continued growth.

64 ila is an amoebae host-adapted effector that subverts encystation of the amoebae natural host, and th

65 We found that the cellular Rpn11 is subverted for tombusvirus replication and Rpn11 has a pr

66 ghly infectious bacterial pathogens avoid or subvert host autophagy mechanisms normally employed to m

67 ptor (PRR)-mediated inflammatory response to subvert host cell functions by using various virulence f

68 of bacterial effectors into host cells that subvert host cell membrane trafficking, leading to the b

69 thogens have evolved intricate mechanisms to subvert host cell signaling pathways and ensure their ow

70 These effectors subvert host cell signaling pathways to ensure bacterial

71 manipulate host cell signaling pathways and subvert host defense mechanisms.

72 r proteins directly into eukaryotic cells to subvert host functions.

73 g HIV and hepatitis C virus, to overwhelm or subvert host immune responses contributes to a prolonged

74 Pathogens use numerous methods to subvert host immune responses, including the modulation

75 Understanding how viruses subvert host immunity and persist is essential for devel

76 te hundreds of effectors into plant cells to subvert host immunity and promote pathogenicity on their

77 ), we investigated whether these drugs might subvert host immunity by activating PAF-R.

78 oral bacterium Porphyromonas gingivalis, can subvert host immunity to remodel a normally symbiotic mi

79 To subvert host immunity, influenza A virus (IAV) induces e

80 ciated EV-D68, have developed a mechanism to subvert host innate immune responses by simultaneously t

81 d EV-D68, have developed novel mechanisms to subvert host innate immune responses by targeting key fa

82 h its hosts, PEDV has acquired mechanisms to subvert host innate immune responses for its survival ad

83 cular structures enable microbial enzymes to subvert host lipid signaling, suppress inflammation, and

84 Many intracellular pathogens subvert host membrane trafficking pathways to promote th

85 e that the Znu system allows A. baumannii to subvert host nutritional immunity and acquire Zn during

86 revealed an important bacterial strategy to subvert host responses in infected cells, demonstrating

87 Bacteria masterfully co-opt and subvert host signal transduction.

88 ve also extensively co-opted the OTU fold to subvert host signaling, but the extent to which bacteria

89 es that pathogens have evolved mechanisms to subvert host-mediated zinc withholding, and these metal

90 dylethanolamine and sterol lipids within the subverted host membranes to promote optimal viral replic

91 This suggested that CteG might function by subverting host cell vesicular transport.

92 amily, are likely to play important roles in subverting host defenses, and constitute a valuable pool

93 e that supports intracellular replication by subverting host proteins that control biogenesis and fus

94 We show that the virus subverts host cell trafficking pathways to effect the re

95 Staphylococcus aureus subverts host defences by producing a collection of viru

96 The human pathogen Shigella flexneri subverts host function and defenses by deploying a cohor

97 The malaria causing parasite Plasmodium subverts host immune responses by several strategies inc

98 filarial nematode Acanthocheilonema viteae, subverts host immune responses towards anti-inflammatory

99 thermore, our results show that P. infestans subverts host immunity by repressing the AS of positive

100 by 3C(pro) may be a mechanism by which EV68 subverts host innate immune responses.

101 Our understanding of how rotavirus (RV) subverts host innate immune signaling has greatly increa

102 of glycosyltransferase effectors employed to subvert hosts.

103 observations, we propose a model whereby WNV subverts human DC activation to compromise priming of WN

104 Tumors subvert immune cell function to evade immune responses,

105 iological responses in host cells thought to subvert immune defenses.

106 ccessfully infect host cells, pathogens must subvert immune responses and avoid detection to prevent

107 al and non-professional phagocytic cells and subvert immune responses for chronic persistence in the

108 us (HBV) has been described as stealth virus subverting immune responses initially upon infection.

109 Cancers are able to grow by subverting immune suppressive pathways, to prevent the m

110 Because S. aureus biofilms are capable of subverting immune-mediated clearance, we examined whethe

111 N. meningitidis subverts immune responses by hijacking a host-immune reg

112 pothesize that this effect of FLT3-ITD might subvert immunosurveillance and promote leukemogenesis in

113 Unexpectedly, this system is subverted in B cell lymphomas harboring translocations t

114 sponses to injury, a continuum that often is subverted in cancer.

115 various mechanisms and consider how they are subverted in disease.

116 f signaling by regulatory IDPs, which can be subverted in human disease.

117 beta-dependent program of gene expression is subverted in SCCs from various body sites, and there are

118 nize and eliminate myeloma, although this is subverted in the majority of patients who eventually suc

119 inant in the M1T1 GAS clone, allowing GAS to subvert innate immune functions that are critical in cle

120 It is well established that UPEC can subvert innate immune responses, but the role of UPEC in

121 ance uses multiple mechanisms to effectively subvert innate immune-mediated zinc poisoning for system

122 Many pathogens subvert intestinal immunity to persist within the gastro

123 HIV and simian immunodeficiency virus (SIV) subvert intracellular membrane traffic as part of their

124 These viruses subvert intracellular membranes for virus replication an

125 retain dependency on the target oncogene or subvert it through a parallel pathway.

126 he chemical cues evolved by the parasites to subvert its host defences.

127 (hypoxia) is a major stressor that generally subverts life of aerobic species and is a prominent feat

128 e may select for pneumococci, which avoid or subvert macrophage NF-kappaB activation.

129 2-dependent negative regulatory mechanism to subvert macrophage-mediated innate immune defense agains

130 uggest that L. donovani may exploit SOCS for subverting macrophage apoptotic machinery toward establi

131 any intracellular pathogens cause disease by subverting macrophage innate immune defense mechanisms.

132 Tumors frequently subvert major histocompatibility complex class I (MHC-I)

133 2'-O methylation of the 5' cap of viral RNA subverts mammalian antiviral responses by evading restri

134 These viruses subvert many aspects of the innate and adaptive immune r

135 The subverted membranes facilitate the assembly of viral rep

136 that expression of mutant JAK2 augmented and subverted metabolic activity of MPN cells, resulting in

137 n response, bacteria have evolved systems to subvert metal sequestration and toxicity.

138 Adenoviruses (Ads) subvert MHC class I Ag presentation and impair host anti

139 s, suggesting that influenza virions form by subverting microvesicle production.

140 proteins in the miRNA biogenesis pathway to subvert miRNA-induced antiviral effects.

141 The findings in this study suggest that CVB subverts mitophagy machinery to support viral disseminat

142 tigen array signifies a unique approach that subverts monotypic immunodominance and allows otherwise

143 two important viral pathogens that naturally subvert multiple death pathways via a single evolutionar

144 MPA, but not NET-A, subverts mycobacterial containment in vitro and downregu

145 onaute pathway may play a pathogenic role in subverting neuronal function in FXTAS.

146 to inject proteins into eukaryotic cells to subvert normal cellular functions.

147 re commonly activated in acute leukemias and subvert normal gene expression networks to reprogram hem

148 at dynamic feedback between tumor and stroma subverts normal inflammatory responses by triggering the

149 ng enzyme functional diversity, that help to subvert obstacles presented by the human host, which per

150 However, some viruses can subvert or even enhance host autophagic machinery to inc

151 t become clinically manifest have managed to subvert or hide from immunosurveillance.

152 ted microbes to manipulate these pathways to subvert or inhibit plant defense.

153 HCMV) employs numerous strategies to combat, subvert, or co-opt host immunity.

154 y viruses, bacteria, and parasites to alter, subvert, or otherwise manipulate host DNA damage and rep

155 ectly infects subsets of monocytic cells and subverts overall immune responses.

156 uses an enzyme, GlpQ, to hydrolyze ChoP and subvert PAF function, suggesting that mimicry-driven imm

157 pects of this explanation have been recently subverted, particularly those related to how GTP-tubulin

158 In summary, various (+)RNA viruses might subvert PE to build membrane-bound VRCs for robust repli

159 tes mutations in bacteria that allow them to subvert phage infection, but with a cost to their fitnes

160 e data support predictions that rhizobia can subvert plant defenses and evolve to exploit hosts.

161 To manipulate host cell physiology and subvert plant immune responses, pathogens secrete an arr

162 he microtubule-associated protein MAP65-1 to subvert plant immunity.

163 egulatory mechanisms through which pathogens subvert plant immunity.

164 presses NPR1-dependent SA signaling, thereby subverting plant innate immunity.

165 These findings reveal a natural means of subverting PRC1 activity, linking key epigenetic modulat

166 effect induced by some microbial products to subvert production of antigen-specific immune responses.

167 ons, many pathogens have evolved to avoid or subvert pyroptosis.

168 Cancer is a disease of subverted regulatory pathways.

169 ver a mechanism by which an enteric pathogen subverts repair processes by targeting stem cells during

170 Viruses activate inflammasomes but then subvert resulting inflammatory responses to avoid elimin

171 Unlike other effector proteins that subvert Rho GTPases to modulate uptake, CirA is the firs

172 A proviral role to subvert RNA silencing through binding of these host RNP

173 The results of ZIKV relocalizing and subverting select stress granule proteins might have bro

174 direct compensation, whereas others do so by subverting senescence or tumor-suppressor pathways.

175 in (HlyA) insert into host-cell membranes to subvert signal transduction and induce apoptosis and cel

176 In this review, we focus on effectors that subvert signaling pathways that impact on endosomal traf

177 novirus early region 4 ORF4 protein (E4orf4) subverts signaling by Src family kinases (SFK) to pertur

178 Bacterial pathogens subvert signalling pathways to promote invasion and/or r

179 s focused on novel approaches that strive to subvert skin's excellent barrier function, and broaden t

180 s and pathobionts have evolved strategies to subvert spatial restrictions, thereby undermining immune

181 e a dual role of sensing the environment and subverting specific host defense processes.

182 sequences of ZIKV modulating SG assembly and subverting specific SG proteins are alterations to cellu

183 icts SG assembly, likely by relocalizing and subverting specific SG proteins to modulate ZIKV replica

184 to microbes that have devised strategies to subvert Stat1-dependent responses.

185 rms race, viruses have evolved strategies to subvert sumoylation.

186 enhances virulence, suggesting that bacteria subvert syndecan-1 ectodomains released by shedding for

187 ode large arsenals of molecules that seek to subvert T cell and natural killer cell function via a re

188 rogrammed death-1 (PD-1) ligand 1 (PD-L1) to subvert T-cell-mediated immunosurveillance.

189 Notch4 subverted T(reg) cells into the type 2 and type 17 helpe

190 sculature in supporting immunoevasion and in subverting T cell-mediated immunosurveillance.

191 Ablation of ITK subverts Th2 immunity, thereby potentiating Th1-based im

192 ally to the germ cells of transgenic mice to subvert the activity of endogenous receptors.

193 th cellular factors to disrupt signaling and subvert the cell cycle.

194 ow a lentiviral accessory protein is able to subvert the cell's normal protein degradation pathway to

195 Persistent virus is able to subvert the cellular interferon response, a powerful bra

196 rect afferents by deep brain stimulation may subvert the clinical efficacy of deep brain stimulation.

197 s against avirulent mutants that exploit and subvert the division of labor within these populations.

198 mor response, immune regulatory pathways can subvert the effector phase and enable tumor escape.

199 nding can inform therapeutic strategies that subvert the evolution of drug resistance.

200 rax, relies on multiple virulence factors to subvert the host immune defense.

201 encode chemokines and chemokine receptors to subvert the host immune response.

202 w that LANA blocks MHC-II gene expression to subvert the host immune system by disrupting the MHC-II

203 HIV-1 envelope protein (Env) has evolved to subvert the host immune system, hindering viral control

204 type II decoy receptors used by poxvirus to subvert the host innate immune response would be an attr

205 ucleoprotein and phosphorylation protein, to subvert the host innate immune system.

206 ggest a novel mechanism that CVB3 employs to subvert the host signaling and facilitate consequent vir

207 To subvert the host's immune response, Y. enterocolitica us

208 athogenic microbes often release toxins that subvert the host's immune responses to render the enviro

209 n most common strategies that viruses use to subvert the IFN response with examples from publications

210 How they subvert the immune check-point function of the spleen to

211 ogens have adopted an array of mechanisms to subvert the immune pathways of their respective hosts.

212 at mediate the host-pathogen interaction and subvert the immune response are shut off at intermediate

213 onism by specific pathogenic flaviviruses to subvert the immune response in infected DCs.IMPORTANCE F

214 s been hypothesized that sGP may potentially subvert the immune response or may contribute to pathoge

215 results show how pandemic influenza viruses subvert the immune response.

216 tly considered one of the pathogens that can subvert the immune system by limiting the activation of

217 Bacteria subvert the immune system by suppressing antimicrobial r

218 athogens that utilize 2'-O-MTase activity to subvert the immune system.

219 rsistently replicating viruses outcompete or subvert the initial antiviral response, allowing the est

220 Mycobacterium tuberculosis (MTB) is able to subvert the innate immune response and survive inside ma

221 lved several ways to target IRF3 in order to subvert the innate immune response.

222 g RNA transcript employed by adenoviruses to subvert the innate immune system protein double-stranded

223 Bacterial pathogens often subvert the innate immune system to establish a successf

224 ens have developed specialized strategies to subvert the mammalian immune response controlled by the

225 he need for defining how prostate metastases subvert the MSC-osteoblast differentiation program.

226 e monocytes are short-lived cells, HCMV must subvert the natural short life-span of these blood cells

227 intact TIR domain was essential for TcpB to subvert the non-canonical inflammasome activation as a T

228 ABC) different carbazole units, we needed to subvert the synthetic preferences for one-pot macrocycli

229 Influenza viruses subvert the transcriptional machinery of their hosts to

230 immunity and that a range of plant pathogens subvert the ubiquitin-proteasome system to enhance their

231 Furthermore, inactivation of the MSH pathway subverted the expression of whiB3 along with other pH-sp

232 enesis by affecting genomic stability and by subverting the cellular molecular signaling machinery an

233 d for virulence of Francisella tularensis by subverting the host innate immune response.

234 An important player in subverting the host response to HCV infection is the vir

235 exploit sophisticated approaches, including subverting the immune system, hijacking host factors, an

236 ealth, evasion and persistence strategies in subverting the onslaught of host immune response during

237 eptidase cleaves the SNARE complex proteins, subverting the synaptic exocytosis responsible for acety

238 Here, we have shown how HCV subverts the ability of NK cells to positively mediate c

239 e that activity-dependent Cl(-) accumulation subverts the actions of PV(+) interneurons to perpetuate

240 HCV subverts the antiviral actions of these miRNAs by dampen

241 enomic analyses to elucidate how P. syringae subverts the attack and defense responses of the cohabit

242 Vpr subverts the DDB1-cullin4-associated-factor 1 (DCAF1) ad

243 We describe a mechanism by which HPV E7 subverts the function of RNF168 at DNA double-strand bre

244 HCMV lytic infection subverts the host cell cycle machinery in multiple ways.

245 cific Us3 kinase as an mTORC1 activator that subverts the host cell energy-sensing program to support

246 How Vibrio subverts the host defenses to mount a successful infecti

247 trate a mechanism by which this binary toxin subverts the host immune response.

248 ogy are uncovering in growing detail how Nef subverts the host immune system, facilitates virus relea

249 Shigella flexneri invades and subverts the human colonic epithelium by the injection o

250 for the mechanisms by which PVM efficiently subverts the IFN response of the murine cell.

251 Understanding how S. aureus subverts the immune response is critical for the rescue

252 Understanding the mechanisms by which Tax subverts the immune system may lead to the development o

253 findings provide a miRNA-based strategy that subverts the immunosuppression of CTLs that is often obs

254 Here we demonstrate that GITR ligation subverts the induction of Foxp3(+) Tregs and directs the

255 her, our data indicated that IL-25 signaling subverts the induction of protective immunity and amplif

256 at protein, or a nonfunctioning protein that subverts the molecular system within which the protein w

257 establish that the HSV-1 Us3 protein kinase subverts the normal response to low-energy-induced stres

258 ytes to facilitate viral dissemination, HCMV subverts the short 48-h life span of monocytes by induci

259 2, released by the host on pathogen contact, subverts the tyrosine signaling network of a number of b

260 ors are enzymes that modify host proteins to subvert their normal functions.

261 nstrate that Tregs can finely adapt, or even subvert, their classical inhibitory machinery in distinc

262 w of these processes, pathogen strategies to subvert them, and their crosstalk with various cell deat

263 corticoid surge and Tsc22d3 upregulation can subvert therapy-induced anticancer immunosurveillance.

264 ncode inhibitors of programmed cell death to subvert these host responses during infection, thereby f

265 specific mechanisms by which microorganisms subvert these host responses have been uncovered.

266 lved diverse anti-CRISPR (Acr) proteins that subvert these immune systems.

267 esponse, DENV has developed numerous ways to subvert these intracellular antiviral responses and dire

268 Nascent tumors must subvert these mechanisms to achieve cancerous overgrowth

269 gens and demonstrated how pathogen effectors subvert these mechanisms.

270 To subvert these pathways and suppress the antimicrobial re

271 volved multiple strategies to inhibit and/or subvert these pathways and to take advantage of their in

272 drate diets have been suggested to partially subvert these processes by increasing energy expenditure

273 hage killing ability, explored how pathogens subvert these responses, identified subsets of macrophag

274 t human pathogens have evolved mechanisms to subvert these responses.

275 the vertebrate host via the salivary glands; subverting these processes could be used to interrupt pa

276 veterinary practices directly or indirectly subvert this 'illness-mediated anorexia'.

277 onella enterica serovar Typhi, can partially subvert this critical innate immune recognition event.

278 ruses causing chronic infections are able to subvert this immune response and represent a human healt

279 mechanisms used by malignant brain tumors to subvert this innate type of immune surveillance remain u

280 However, sialic acid-expressing pathogens subvert this mechanism through molecular mimicry.

281 As such, viruses have evolved strategies to subvert this potent antiviral response.

282 t surprising that viruses have found ways to subvert this process.

283 Some pathogens may subvert this response to promote infection through manip

284 in, providing an unparalleled opportunity to subvert this viral protein as a tumour-specific target.

285 vo, H. influenzae has evolved mechanisms for subverting this host defense, most of which have been sh

286 By understanding how these 4 foci are subverted to cause disease, we aim to improve the identi

287 er, how the functional activity of PrP(C) is subverted to deliver neurotoxic signals remains uncertai

288 he general reducing power of bacteria can be subverted to induce the abiotic production of a carbon-c

289 s from liver sinusoidal endothelial cells is subverted to promote fibrosis.

290 chronic tissue inflammation this role may be subverted to promote tumour growth.

291 regs are developmentally linked and GITR can subvert tolerogenic conditions to boost Th9 immunity.

292 ed it as being a dominant negative ligand to subvert TRAIL-mediated killing.

293 genic driver activate divergent pathways and subvert transformation.

294 l., 2018), and demonstrated that viruses can subvert type III CRISPR immunity by means of a potent an

295 t selection of viral CD8 escape variants can subvert vaccine-conferred immunity.

296 The oxidation instability of I is subverted via its incorporation into the coordinated str

297 the mechanism by which human cytomegalovirus subverts viperin; they also provide a biochemical ration

298 as well as antiviral factors responsible for subverting viral infection.

299 ve, alternative preventive approach where we subvert virus-induced pneumococcal disease without inter

300 efficacy in treating Wnt-driven cancers and subverting Wnt-mediated therapy resistance in preclinica