ライフサイエンスコーパス: succinate dehydrogenase

1 ane-bound proteins (NADH dehydrogenase I and succinate dehydrogenase).

2 ating variants in genes encoding subunits of succinate dehydrogenase.

3 ropionate, a known irreversible inhibitor of succinate dehydrogenase.

4 h1, a subunit of the heterotetrameric enzyme succinate dehydrogenase.

5 ired for mitochondrial metabolism, including succinate dehydrogenase.

6 alpha-ketoglutarate dehydrogenase (KGDH) and succinate dehydrogenase.

7 emical staining for cytochrome c oxidase and succinate dehydrogenase.

8 n, affects respiratory electron flow through succinate dehydrogenase.

9 eing a consequence of the effects of 3NPA on succinate dehydrogenase.

10 ctase-phospholipid vesicles replenished with succinate dehydrogenase.

11 acetate (OAA) accumulation and inhibition of succinate dehydrogenase.

12 ropionic acid (3-NP), a suicide inhibitor of succinate dehydrogenase.

13 reconstitutive activity of the mitochondrial succinate dehydrogenase.

14 ronments are not affected by the presence of succinate dehydrogenase.

15 ve form of OAA that is a strong inhibitor of succinate dehydrogenase.

16 least in part to oxaloacetate inhibition of succinate dehydrogenase.

17 ndrial proteins such as lipoate synthase and succinate dehydrogenase.

18 ive phosphorylation Complex I, sirtuin 3 and succinate dehydrogenase.

19 es in the iron-sulfur enzymes, aconitase and succinate dehydrogenase.

20 dehydrogenase I, NADH dehydrogenase II, and succinate dehydrogenase.

21 analysis, pyruvate dehydrogenase complex and succinate dehydrogenase.

22 y sensitive to the irreversible inhibitor of succinate dehydrogenase 3-nitropropionic acid (3-NP).

23 2 mV) increases slightly when complexed with succinate dehydrogenase (34 mV).

24 er normoxic conditions through regulation of succinate dehydrogenase A (SDHA) and fumarate hydratase

25 red, leading to reduced glutathionylation of succinate dehydrogenase A (SDHA), a key component of ele

26 ome c oxidase subunits 1 and 2) and nuclear (succinate dehydrogenase A) DNA-encoded respiratory chain

27 The enzyme activity of succinate dehydrogenase, a control for mGPD, was normal

28 transcription of genes encoding subunits of succinate dehydrogenase, a Fe-requiring enzyme.

29 ining proteins are down-regulated, including succinate dehydrogenase, aconitase, cytochromes, and bio

30 Time-resolved kinetic measurements of succinate dehydrogenase activation by succinate furtherm

31 x II relative to complexes I + II and higher succinate dehydrogenase activities in both mitochondrial

32 analyses of the catalysis and inhibition of succinate dehydrogenase activities in samples with both

33 increased hydroxyacyl-coA dehydrogenase and succinate dehydrogenase activities, decreased lactate de

34 to have reduced mitochondrial aconitase and succinate dehydrogenase activities.

35 f reactive oxygen species (ROS); 2) decrease succinate dehydrogenase activity (complex II of the elec

36 oxidase activity (COX-), hyperreactivity for succinate dehydrogenase activity (SDH++; also known as r

37 e in capillary density and a 23% increase in succinate dehydrogenase activity after 3 months of condi

38 ex II's electron transport function from its succinate dehydrogenase activity also suggested a mechan

39 The mutant strain also lacked succinate dehydrogenase activity and did not grow with a

40 y 4HNE is shown to involve the disruption of succinate dehydrogenase activity and subsequent activati

41 py, and function by cytochrome c oxidase and succinate dehydrogenase activity assays.

42 ere was, however, a significant reduction in succinate dehydrogenase activity associated with OAT act

43 :cat(+) strain exhibited wild-type levels of succinate dehydrogenase activity both in vivo and in vit

44 This indicates that succinate dehydrogenase activity had been blocked by the

45 Succinate dehydrogenase activity in islet mitochondrial

46 Peak VO2 was strongly related to integrated succinate dehydrogenase activity in patients (r = 0.896,

47 respiratory complex protein expression, and succinate dehydrogenase activity in skeletal muscles.

48 arate was provided to alleviate the need for succinate dehydrogenase activity in the tricarboxylic ac

49 A::cat(+) strain was completely deficient in succinate dehydrogenase activity in vitro and was unable

50 Moreover, in vitro succinate dehydrogenase activity observed in wild-type m

51 Lower mu(a) and lower succinate dehydrogenase activity of the fatty liver sugg

52 To assess mitochondrial integrity, succinate dehydrogenase activity was measured in transdu

53 Whole muscle succinate dehydrogenase activity was reduced by 12 +/- 0

54 sectional area was smaller, and single-fiber succinate dehydrogenase activity, a mitochondrial oxidat

55 tch, and increases in mitochondrial markers, succinate dehydrogenase activity, and angiogenesis.

56 rmogenesis, indicated by increases in muscle succinate dehydrogenase activity, SLN expression, mitoch

57 29SVEMS mice have a significant reduction of succinate dehydrogenase activity, succinate oxygen consu

58 r wild type grown under conditions requiring succinate dehydrogenase activity, suggesting that the su

59 and a reduction of cytochrome c oxidase and succinate dehydrogenase activity, when compared with non

60 that adaphostin had no effect on pyruvate or succinate dehydrogenase activity.

61 n approximate 50% decrease in complex II and succinate dehydrogenase activity.

62 fibers, smaller fast twitch fibers and lower succinate dehydrogenase activity.

63 espiratory complex II without fully blocking succinate dehydrogenase activity.

64 containing 5 coimmunoprecipitating proteins (succinate dehydrogenase, adenine nucleotide translocator

65 l cytochemistry for cytochrome c oxidase and succinate dehydrogenase allowed the detection of cytochr

66 onsumption of soy was associated with higher succinate dehydrogenase alpha levels and lower levels of

67 Expression of the TCA cycle protein succinate dehydrogenase alpha was decreased in animals t

68 presence of oxidized cytochrome c, purified succinate dehydrogenase also catalyzed oxidation of succ

69 The homologous enzyme succinate dehydrogenase also plays a prominent role in c

70 ition of the tricarboxylic acid cycle enzyme succinate dehydrogenase, also known as complex II of the

71 Malonic acid methyl ester, an inhibitor of succinate dehydrogenase, also specifically increased glu

72 and for the function, but not stability, of succinate dehydrogenase, an important component of the e

73 into a reconstitutively active, two-subunit succinate dehydrogenase and a two-subunit membrane ancho

74 further confirmed by observing decreases in succinate dehydrogenase and aconitase activities, whose

75 Strains with isc lesions had reduced succinate dehydrogenase and aconitase activities.

76 hern Sweden, with associated deficiencies of succinate dehydrogenase and aconitase in skeletal muscle

77 ted with a myopathy resulting from deficient succinate dehydrogenase and aconitase.

78 hondrial (mt) DNA and polypeptide abundance, succinate dehydrogenase and cytochrome oxidase histochem

79 s that TRX may deactivate both mitochondrial succinate dehydrogenase and fumarase and activate the cy

80 ccinyl-CoA ligase mutants, elevated again in succinate dehydrogenase and fumarase mutants, and dimini

81 h shuts down the Krebs cycle by inactivating succinate dehydrogenase and fumarase.

82 which can accumulate to millimolar levels in succinate dehydrogenase and fumarate hydratase-mutant tu

83 rity to genes coding for the FeS subunits of succinate dehydrogenase and fumarate reductase, were del

84 ty of two mitochondrial iron-sulfur enzymes, succinate dehydrogenase and mitochondrial aconitase, as

85 Complex II of mitochondria contains succinate dehydrogenase and subunits to link this enzyme

86 Isolated succinate dehydrogenase and the SdhC-SdhD fraction alone

87 arkers of mitochondria (citrate synthase and succinate dehydrogenase) and glucose uptake capacity (GL

88 mRNAs for sodB (superoxide dismutase), sdh (succinate dehydrogenase), and a gene encoding a bacterio

89 sdh3 and sdh4 (encoding subunits 3 and 4 of succinate dehydrogenase), and we also show that these ge

90 d the activities of NADH dehydrogenase (ND), succinate dehydrogenase, and cytochrome c oxidase (COX)

91 ey electron transfer proteins (flavoprotein, succinate dehydrogenase, and cytochrome c) and the synth

92 ities of Fe-S proteins, including aconitase, succinate dehydrogenase, and MiaB.

93 y succinate in the presence of mitochondrial succinate dehydrogenase, and the rate of cytochrome b556

94 es of mitochondrial Fe-S enzymes (aconitase, succinate dehydrogenase, and ubiquinol-cytochrome c oxid

95 All four subunits of succinate dehydrogenase are tumor suppressor genes predi

96 lly encoding alpha-ketoglutarate, malate, or succinate dehydrogenases are identifiable.

97 mRNA levels for the sdhCDAB operon, encoding succinate dehydrogenase, as well as five other genes pre

98 and determines total protein content, and a succinate dehydrogenase assay that uses dichloroindophen

99 and the respiratory chain Complex II subunit succinate dehydrogenase B (SDHB) in mitochondria of tumo

100 e increase in succinate because of decreased succinate dehydrogenase B expression under fibrotic cond

101 th von Hippel Lindau syndrome (VHL; n = 19), succinate dehydrogenase B-D mutation (n = 21), neurofibr

102 -mediated tumorigenesis in patients carrying succinate dehydrogenase-B mutations.

103 electron transport chain Complex II subunit succinate dehydrogenase-B, maintaining cellular respirat

104 y iron-sulfur enzymes, such as aconitase and succinate dehydrogenase, but also alters the regulation

105 ogenase, fumarase, malate dehydrogenase, and succinate dehydrogenase, but not KDH, are present, raisi

106 lie proximal to the divergently transcribed succinate dehydrogenase C gene, but Sdhc expression was

107 ductive pathway in the opposite direction of succinate dehydrogenase, can replace it during infection

108 fumarate reductase (Cj0408 to Cj0410) and a succinate dehydrogenase (Cj0437 to Cj0439).

109 onic acid (3-NP) and malonate, inhibitors of succinate dehydrogenase, compared with control cell line

110 The succinate dehydrogenase complex (complex II) is a highly

111 ffect patients with genetic mutations of the succinate dehydrogenase complex (SDHx).

112 Mechanistically, LONP1 selectively degrades succinate dehydrogenase complex iron sulfur subunit B an

113 PDAC alters mitochondrial function by losing succinate dehydrogenase complex iron sulfur subunit B ex

114 ssive succinate accumulation despite reduced succinate dehydrogenase complex iron-sulfur subunit b (S

115 2.4%; P < .001), COX4 (26.6%; P < .001), and succinate dehydrogenase complex subunit A (65.8%; P = .0

116 ein levels (P = 0.0006 and P = 0.005) of the succinate dehydrogenase complex subunit A and subunit B

117 Furthermore, inhibition of succinate dehydrogenase complex with dimethylmalonate af

118 SDHD encodes subunit D of the succinate dehydrogenase complex, an integral membrane pr

119 t results in the localization of sympathetic succinate dehydrogenase complex, subunit B, mutation-rel

120 ve metabolism in mice with disruption of the succinate dehydrogenase complex, subunit C gene (Sdhc).

121 most commonly a mutation of a subunit of the succinate dehydrogenase complex.

122 Activities of succinate dehydrogenase (complex II) (+44%) and malate d

123 alone, oxaloacetate accumulates and inhibits succinate dehydrogenase (complex II) in a manner depende

124 three sites, NADH dehydrogenase (complex I), succinate dehydrogenase (complex II), and cytochrome c o

125 nal effector function of T(H)1 cells through succinate dehydrogenase (complex II), but that the activ

126 n enzymes NADH-dehydrogenase (complex I) and succinate dehydrogenase (complex II), inactivation of th

127 ted with decreased activity of mitochondrial succinate dehydrogenase (complex II).

128 l0823 open reading frames encode subunits of succinate dehydrogenase complexes that are active in the

129 Cytochrome c oxidase/succinate dehydrogenase (COX/SDH) staining and electron

130 rial respiratory chain (cytochrome c-oxidase/succinate dehydrogenase [COX/SDH]-ratio) was depressed i

131 Succinate dehydrogenase deficiency is a rare leukoenceph

132 s, the differential diagnosis should include succinate dehydrogenase deficiency, in particular if MRS

133 Nineteen individuals with succinate dehydrogenase deficiency-related leukoencephal

134 Succinate dehydrogenase-deficient leukoencephalopathy is

135 rial marker enzymes cytochrome C oxidase and succinate dehydrogenase, demonstrate abnormal accumulati

136 the largest subcomplex (IIa) represents the succinate dehydrogenase domain composed of SDH1 and SDH2

137 umulated succinate is rapidly re-oxidized by succinate dehydrogenase, driving extensive ROS generatio

138 For instance, mitochondrial succinate dehydrogenase enzyme levels as well as carboni

139 conserved throughout the fumarate reductase/succinate dehydrogenase family of enzymes.

140 e identified one of the Complex II subunits, succinate dehydrogenase flavoprotein (SdhA) subunit, as

141 fumarase (fum-1), glyoxylate shunt (gei-7), succinate dehydrogenase flavoprotein (sdha-2), or solubl

142 d in metabolism (ATP synthase alpha-subunit, succinate dehydrogenase flavoprotein [SDH Fp] subunit, a

143 show that the reason for the failure of the succinate dehydrogenase flavoprotein SdhA (an almost-ide

144 opionic acid, an irreversible inactivator of succinate dehydrogenase, forms a covalent adduct with th

145 ubsequent to mutations in the genes encoding succinate dehydrogenase, fumarate hydratase or isocitrat

146 Deletion of SDHD (Succinate dehydrogenase) gene from the complex II in the

147 Itaconate inhibited the activity of succinate dehydrogenase, generating a metabolic state in

148 mutations in the fumarate hydratase (FH) and succinate dehydrogenase genes (SDHA, SDHB, SDHC and SDHD

149 Germline variants in succinate dehydrogenase genes (SDHx) co-occurring with P

150 e patient series that germline variations in succinate dehydrogenase genes (SDHx) occur in 8% (49/608

151 of the virulence-associated Rv0249c-Rv0247c succinate dehydrogenase genes demonstrated that CRP dire

152 ion in paragangliomas harboring mutations in succinate dehydrogenase genes.

153 This treatment reduced succinate dehydrogenase glutathionylation, impaired the

154 Succinate dehydrogenase has a major effect on the PQ red

155 . jejuni and that the protein annotated as a succinate dehydrogenase has been misannotated.

156 tochondrial genes for fumarate hydratase and succinate dehydrogenase have been linked to uterine leio

157 Abundance of the 17-kd subunit of complex I, succinate dehydrogenase histochemical activity, and cris

158 ETS-abnormal, cytochrome c oxidase-negative/succinate dehydrogenase-hyperreactive (COX-/SDH++) fiber

159 These data indicate that Frd is the only succinate dehydrogenase in C. jejuni and that the protei

160 ty possibly resulting from inhibition of the succinate dehydrogenase in heart mitochondria, contribut

161 nfection by running in the same direction as succinate dehydrogenase in order to run a full TCA cycle

162 PQI toxicity in isolated liver mitochondria (succinate dehydrogenase inactivation, SDH) from these ra

163 lectrons to fumarate through the reversal of succinate dehydrogenase, independent of environmental O(

164 ction and the most significant member of the succinate dehydrogenase inhibitor group of fungicides.

165 Inactivation of succinate dehydrogenase is a key event in the evolutiona

166 Kinetic results indicated that succinate dehydrogenase is activated by both ATP (K(1/2)

167 ly that flavinylation of the Sdh1 subunit of succinate dehydrogenase is dependent on a set of two spa

168 esults demonstrate that in vitro activity of succinate dehydrogenase is modulated by the protonmotive

169 The iron-sulfur subunit of succinate dehydrogenase is one of the four subunits of c

170 complete tricarboxylic acid (TCA) cycle and succinate dehydrogenase is small under heterotrophic con

171 These results suggest that reduced FAD of succinate dehydrogenase is the electron donor for oxygen

172 The results indicate that succinate dehydrogenase is the main respiratory electron

173 ivity of Fe-S-containing enzymes (aconitase, succinate dehydrogenase) is decreased, whereas the activ

174 It was previously shown that mutations in succinate dehydrogenase lead to the inactivation PHDs un

175 te transaminase (GOT2) as well as malate and succinate dehydrogenases (MDH2 and SDH) to transfer oxid

176 S-like syndrome, or BRRS have germline SDHx (succinate dehydrogenase, mitochondrial complex II) varia

177 Succinate dehydrogenase mRNA abundance was greater in ce

178 reductase of Wolinella succinogenes and the succinate dehydrogenase of Bacillus subtilis.

179 NA encoding the iron protein (Ip) subunit of succinate dehydrogenase of yeast is its rate of turnover

180 ty between FsrA and the leader region of the succinate dehydrogenase operon is consistent with an RNA

181 cle mutants (sdh2Delta or fum1Delta) lacking succinate dehydrogenase or fumarase activities.

182 eductase activity increases as the amount of succinate dehydrogenase or the SdhC-SdhD fraction added

183 hD fraction is mixed with varying amounts of succinate dehydrogenase or vice versa succinate-ubiquino

184 succinate-ubiquinone reductase) and E. coli succinate dehydrogenase or vice versa.

185 ontrast, similar cation depletion stimulates succinate dehydrogenase (or glutamate dehydrogenase) in

186 A prevalent side-reaction of succinate dehydrogenase oxidizes malate to enol-oxaloace

187 gh potential 3Fe-4S cluster, situated in the succinate dehydrogenase part of the enzyme, and the low

188 teins, YgfY (a DUF339 protein, renamed SdhE; succinate dehydrogenase protein E) and YgfX (a DUF1434 p

189 dehydrogenase activity, suggesting that the succinate dehydrogenase reaction consumes energy.

190 stimated using the lactate dehydrogenase and succinate dehydrogenase reaction, respectively.

191 value of 3.37, obtained by assuming 1 mol of succinate dehydrogenase reacts with 1 mol of SdhC and Sd

192 ation by the Fdh-N formate dehydrogenase and succinate dehydrogenase respectively.

193 -nitropropionic acid (3-NP), an inhibitor of succinate dehydrogenase, Rhes disrupts mitochondrial mem

194 han unimodal distribution of sizes and lower succinate dehydrogenase (SDH) activities for neurons of

195 d origin of each peak were assessed by using succinate dehydrogenase (SDH) activity as the IM marker

196 and analysis of biochemical traits including succinate dehydrogenase (SDH) activity, ATP content and

197 ubling time, and cell survival and growth by succinate dehydrogenase (SDH) activity.

198 sed mitochondrial oxidation of succinate via succinate dehydrogenase (SDH) and an elevation of mitoch

199 ty of ATP resulted from higher activities of succinate dehydrogenase (SDH) and cytochrome c oxidase (

200 ty of ATP resulted from higher activities of succinate dehydrogenase (SDH) and cytochrome c oxidase (

201 Succinate dehydrogenase (SDH) and fumarate hydratase (FH

202 rs was supplied by the recent discovery that succinate dehydrogenase (SDH) and fumarate hydratase (FH

203 CHK2 controlled expression of succinate dehydrogenase (SDH) and intervened with mitoch

204 ency for the tricarboxylic acid cycle enzyme succinate dehydrogenase (SDH) can lead to Leigh-like syn

205 reduction accumulate ubiquinol, driving the succinate dehydrogenase (SDH) complex in reverse to enab

206 5 interact with the catalytic subunit of the succinate dehydrogenase (SDH) complex, a component of bo

207 canonical kinase mutations but instead have succinate dehydrogenase (SDH) deficiency and global DNA

208 Knowledge about succinate dehydrogenase (SDH) deficiency and mutations i

209 mocytomas and paragangliomas associated with succinate dehydrogenase (SDH) deficiency are characteriz

210 analyzed for cytochrome c oxidase (COX) and succinate dehydrogenase (SDH) enzyme activities.

211 tion of myosin heavy chain (MHC) IIB and low succinate dehydrogenase (SDH) expressing myofibers, with

212 The enzyme succinate dehydrogenase (SDH) functions in the citric ac

213 Cytochrome c oxidase (COX) and succinate dehydrogenase (SDH) histochemistry was perform

214 ional role for stretch-induced inhibition of succinate dehydrogenase (SDH) in mediating normoxic HIF1

215 ng mutation in the TCA cycle enzyme complex, succinate dehydrogenase (SDH) in paraganglioma (PGL), it

216 The role of mitochondrial succinate dehydrogenase (SDH) in salicylic acid (SA) sig

217 ntly, decreased that of the metabolic enzyme succinate dehydrogenase (SDH) in the tumor cells.

218 The tricarboxylic acid (TCA) cycle enzyme succinate dehydrogenase (SDH) is a tumor suppressor.

219 Succinate dehydrogenase (SDH) is an inner mitochondrial

220 Mitochondrial complex II or succinate dehydrogenase (SDH) is at the crossroads of ox

221 The enzymatic function of succinate dehydrogenase (SDH) is dependent on covalent a

222 Here, we identify that succinate dehydrogenase (SDH) is essential for maintaini

223 Succinate dehydrogenase (SDH) is inhibited by mitoK(ATP)

224 Mutations in succinate dehydrogenase (SDH) lead to the development of

225 ndrial alteration and by marked increases in succinate dehydrogenase (SDH) levels and activity.

226 rticularly high in tumors with an underlying succinate dehydrogenase (SDH) mutation.

227 nd the highest SUVs are observed in cases of succinate dehydrogenase (SDH) mutations, possibly relate

228 /paragangliomas (PHEOs/PGLs) associated with succinate dehydrogenase (SDH) mutations.

229 Succinate dehydrogenase (SDH) requires a covalent additi

230 activity with cytochrome c oxidase (COX) and succinate dehydrogenase (SDH) staining, retinal layer th

231 LACC1 constitutively associates with succinate dehydrogenase (SDH) subunit A, and amplifies p

232 imutation of additional genes, including the succinate dehydrogenase (SDH) subunit A, B, C, and D gen

233 ith pathogenic variants in the gene encoding succinate dehydrogenase (SDH) subunit B (SDHB) often hav

234 ed by immunohistochemical analysis (IHC) for succinate dehydrogenase (SDH) subunit B, sequencing of S

235 Mutations in genes coding for succinate dehydrogenase (SDH) subunits are believed to c

236 anglioma, is caused by germline mutations in succinate dehydrogenase (SDH) subunits B, C, or D, leadi

237 dehydrogenase (LDH) and decreased levels of succinate dehydrogenase (SDH) were also detected.

238 y of the genes encoding the four subunits of succinate dehydrogenase (SDH), a mitochondrial membrane-

239 actor-1 (HIF-1), but mutations in Complex II-succinate dehydrogenase (SDH), a tumor suppressor, stabi

240 Succinate dehydrogenase (SDH), also known as complex II,

241 nts demonstrated that they were defective in succinate dehydrogenase (Sdh), an enzyme of the tricarbo

242 at alpha-ketoglutarate dehydrogenase (KGDH), succinate dehydrogenase (SDH), and aconitase were suscep

243 A cycle enzymes, fumarate hydratase (FH) and succinate dehydrogenase (SDH), and combined metabolomics

244 rs: mutated isocitrate dehydrogenases (IDH), succinate dehydrogenase (SDH), and fumarate hydratase (F

245 ial metabolite succinate during ischemia via succinate dehydrogenase (SDH), and this succinate is rap

246 ic acid (TCA) cycle, including aconitase and succinate dehydrogenase (SDH), are major targets of FsrA

247 have been identified in the metabolic genes succinate dehydrogenase (SDH), fumarate hydratase (FH) a

248 Mitochondrial complex II, also known as succinate dehydrogenase (SDH), is an integral-membrane h

249 ation disrupts the TCA cycle at the level of succinate dehydrogenase (SDH), leading to succinate accu

250 bstrate methylmalonyl-CoA and which inhibits succinate dehydrogenase (SDH), produced dose-related cel

251 rt that suppression requires inactivation of succinate dehydrogenase (SDH), which greatly reduces the

252 Although there was no difference in percent succinate dehydrogenase (SDH)-positive (type I) and SDH-

253 rs, type-I NAD(P)H dehydrogenase (NDH-1) and succinate dehydrogenase (SDH).

254 a TCA derivative, itaconate, an inhibitor of succinate dehydrogenase (SDH).

255 Germline mutations in three of the succinate dehydrogenase (SDH, mitochondrial complex II)

256 sophila mutant with a defect in subunit b of succinate dehydrogenase (SDH; mitochondrial complex II).

257 Mutations in mitochondrial complex II (succinate dehydrogenase; SDH) genes predispose to paraga

258 coding subunit B of the mitochondrial enzyme succinate dehydrogenase (SDHB) predispose to malignant p

259 s cycle enzymes, fumarate hydratase (FH) and succinate dehydrogenase (SDHB, -C and -D), act as tumour

260 Succinate dehydrogenase (sdhCDAB) gene expression in Esc

261 d by mutations in genes encoding subunits of succinate dehydrogenase (SDHx) complex.

262 ioma carry a germline mutation in one of the succinate dehydrogenase (SDHx) genes (SDHA, SDHB, SDHC a

263 ectively recruited into two genetic cohorts (succinate dehydrogenase [SDHx]-mutated v apparent sporad

264 The structure of Escherichia coli succinate dehydrogenase (SQR), analogous to the mitochon

265 ady-state levels of the catalytic complex II succinate dehydrogenase subunit A alongside hyperpigment

266 ed germline mutations in SDHA, which encodes succinate dehydrogenase subunit A, in all three patients

267 Mutations of succinate dehydrogenase subunit B (SDHB) play a crucial

268 Analysis of the proteins in TCA cycle showed succinate dehydrogenase subunit B (SDHB) was nearly depl

269 tivation triggers Complex II disassembly and succinate dehydrogenase subunit B loss through sequestra

270 and aggressiveness in certain patients with succinate dehydrogenase subunit B(SDHB) mutations sugges

271 ransport chain with a down-regulation of the succinate dehydrogenase subunit B, leading to deregulati

272 sidues lie at the protein-lipid interface of succinate dehydrogenase subunit B.

273 r-suppressor gene and germline variations in succinate dehydrogenase subunit D gene (SDHD-G12S, SDHD-

274 tations in SDHD, a mitochondrial complex II (succinate dehydrogenase) subunit gene at chromosome band

275 VHL, NF-1, c-Ret, and Succinate Dehydrogenase Subunits B and D act on a develo

276 Loss of different succinate dehydrogenase subunits can lead to different c

277 Germline mutations in succinate dehydrogenase subunits SDHB-D cause pheochromo

278 tural and catalytic properties of beef heart succinate dehydrogenase (succinate-ubiquinone oxidoreduc

279 enase (complex II), but that the activity of succinate dehydrogenase suppresses T(H)1 cell proliferat

280 acid (3-NP), is an irreversible inhibitor of succinate dehydrogenase that induces apoptosis in vitro

281 nitropropionic acid (3-NP) are inhibitors of succinate dehydrogenase that produce energy depletion an

282 itution is obtained when the weight ratio of succinate dehydrogenase to the SdhC-SdhD fraction reache

283 -nitropropionic acid (3-NP), an inhibitor of succinate dehydrogenase, to produce neurodegeneration.

284 twitch markers [myosin heavy chain 7 (MyH7), succinate dehydrogenase, troponin I 1, troponin C1, trop

285 ding the VHL, MET, FLCN, fumarate hydratase, succinate dehydrogenase, TSC1, TSC2, and TFE3 genes, hav

286 H:Ubiquinone Oxidoreductase Core Subunit S1, Succinate dehydrogenase, Ubiquinol-Cytochrome C Reductas

287 ow lactate dehydrogenase activity and strong succinate dehydrogenase velocity.

288 = 1), SDHB (n = 2), and SDHD (n = 4) (SDH is succinate dehydrogenase); von Hippel-Lindau (VHL; n = 2)

289 nsistent with itaconate's ability to inhibit succinate dehydrogenase, VPA treatment of human hearts i

290 The electron donation capacity of succinate dehydrogenase was found to be an order of magn

291 Regulation of succinate dehydrogenase was investigated using tightly c

292 In Escherichia coli, expression of succinate dehydrogenase was necessary for OAT1-associate

293 When succinate dehydrogenase was reconstituted with the bc1 p

294 r), malate dehydrogenase was unaffected, and succinate dehydrogenase was stimulated by Zn(2+).

295 The sdhCDAB operon, encoding succinate dehydrogenase, was cloned from the soybean sym

296 e-S cluster-containing enzymes aconitase and succinate dehydrogenase were dramatically reduced.

297 ndrial Fe-S enzymes, including aconitase and succinate dehydrogenase, were not affected.

298 -CoA to succinate, and a DeltasdhCDA mutant (succinate dehydrogenase), which blocks the conversion of

299 ccinate accumulation arises from reversal of succinate dehydrogenase, which in turn is driven by fuma

300 In contrast, succinate dehydrogenase, with high potential clusters, g