ライフサイエンスコーパス: suggest a mechanism

1 cancer types that carry SF3B1 mutations and suggest a mechanism-based therapeutic approach for treat

2 le resistance to BRAF inhibitors in melanoma suggests a mechanism-based strategy to limit resistance

3 In summary, our data suggest a mechanism by which ACTN1 determines the motili

4 cannabinoid self-administration in adulthood-suggest a mechanism by which adolescent cannabis exposur

5 Taken together, these data suggest a mechanism by which alphavbeta8, ccl20, and ccr

6 These data suggest a mechanism by which aminopeptidase access is de

7 Our results suggest a mechanism by which cross-talk between DISC1 an

8 Together, these combined findings suggest a mechanism by which damage to the medial dience

9 Our findings suggest a mechanism by which diverse perturbations can a

10 The results suggest a mechanism by which EBV recruits cellular repai

11 rt chain, which compromise bioenergetics and suggest a mechanism by which ET-1 promotes neurodegenera

12 ed by sensory and motor input, these results suggest a mechanism by which functional connectivity and

13 Taken together, these data suggest a mechanism by which HIV-1-infected T cells sens

14 f MBCs in maintaining imprinting effects and suggest a mechanism by which imprinting might confer het

15 lorecognition of graft parenchymal cells and suggest a mechanism by which indirect-pathway CD4 T cell

16 ubjective value representation in humans and suggest a mechanism by which individuals vary in neural

17 Our data suggest a mechanism by which interaction specificity and

18 Our findings suggest a mechanism by which intranasal OT may bolster s

19 Taken together, our data suggest a mechanism by which IRAK4 activity regulates TA

20 This is the first study to suggest a mechanism by which LPS stimulation drives Cdc4

21 The results suggest a mechanism by which neuronal release of transmi

22 Our results suggest a mechanism by which physiological signals, such

23 These observations suggest a mechanism by which structural events inside th

24 These results suggest a mechanism by which TGF-beta and TLR9 responses

25 These data suggest a mechanism by which the hydroxylase is tuned fo

26 nscription factors to the PLPP3 promoter and suggest a mechanism by which the LPP3 substrate, LPA, ca

27 ortant interplay between GAPDH and TRAF3 and suggest a mechanism by which the NleB effector inhibits

28 Our data suggest a mechanism by which the Sp factors control appe

29 BG as a neural correlate of PD insomnia and suggest a mechanism by which this disorder could emerge.

30 om its succinate dehydrogenase activity also suggested a mechanism by which Myc generates reactive ox

31 esynaptic proteins that regulate exocytosis, suggesting a mechanism by which APP tunes transmitter re

32 promoters modulates chromatin condensation, suggesting a mechanism by which ARID4B activates these p

33 n of an interaction between GRNs and TDP-43, suggesting a mechanism by which attenuated PGRN function

34 tions that are lost along with pluripotency, suggesting a mechanism by which cancer cells reacquire p

35 multaneous engagement of two Rac1 molecules, suggesting a mechanism by which cells may sense the dens

36 elevated in the sera and liver of cachectic, suggesting a mechanism by which chronic IL-1R signaling

37 n the presence of network-wide correlations, suggesting a mechanism by which cortex could deal with c

38 uced in macrophages during plaque formation, suggesting a mechanism by which enterovirus infect cells

39 circuit of meso-striato-prefrontal regions, suggesting a mechanism by which genetic vulnerability in

40 emonstrate a neuroprotective role of GluN2C, suggesting a mechanism by which GluN2C is upregulated to

41 tivation in the HIV-positive groups, thereby suggesting a mechanism by which HIV-related inflammation

42 provokes global changes in gene expression, suggesting a mechanism by which its deficiency promotes

43 ccessible within this isolated intermediate, suggesting a mechanism by which membrane-associated aggr

44 in hematopoietic stem and progenitor cells, suggesting a mechanism by which NE regulates myelopoiesi

45 idylserine-induced oligomerization of PSR-1, suggesting a mechanism by which PSR-1 activates phagocyt

46 conditions that promote intimal hyperplasia, suggesting a mechanism by which the IL-2/IL-2R system ma

47 at all joint angles would cause depression, suggesting a mechanism by which the stored energy is rel

48 nant and recessive PS-modeled LamC mutations suggests a mechanism by which abnormal lamina organizati

49 nd scan within stalled transcription bubbles suggests a mechanism by which AID can initiate SHM and C

50 The ability to mediate ADCP suggests a mechanism by which anti-HIV-1 envelope Abs ca

51 Our study suggests a mechanism by which Nap1 is recruited to activ

52 Structural analysis suggests a mechanism by which residue 121 impacts the co

53 This suggests a mechanism by which SMAD4 is inactivated in ca

54 This property of procrystalline solids suggests a mechanism by which strongly correlated topolo

55 This finding suggests a mechanism by which supercoiling could regulat

56 which leads to a highly compacted structure, suggests a mechanism by which the protein is activated t

57 This suggests a mechanism by which two cytokines can synergis

58 s to reorganization of response subspace and suggests a mechanism by which value-related signals are

59 ral WM in adolescents and adults with BD and suggest a mechanism contributing to WM pathology in BD.

60 henotype, and plasticity in this species and suggest a mechanism explaining variation in shortgrass s

61 These new interactions suggest a mechanism explaining why A3G exhibits a 3' to

62 Additionally, our results suggest a mechanism for a new type of passive chemical v

63 different conformations of A/B heterodimers suggest a mechanism for ATP hydrolysis that triggers a r

64 Our data suggest a mechanism for bacterial cell filamentation dur

65 biochemical, structural and genetic data, we suggest a mechanism for binding and presentation by RapZ

66 l significance for neuronal MT stability and suggest a mechanism for cellular dysfunction in dynein-l

67 We suggest a mechanism for cholesterol ester accumulation i

68 These results suggest a mechanism for chronoregulation of fetal and ad

69 Our findings suggest a mechanism for cooption of existing chromosomal

70 zed spectroscopY (TROSY) NMR experiments and suggest a mechanism for coupling the energy of nucleotid

71 novel role for ARRB1 in VEGFR regulation and suggest a mechanism for cross talk between G protein-cou

72 ructural effects of M-domain phosphorylation suggest a mechanism for diminishing the functional poten

73 These results suggest a mechanism for dynamically maintaining neural h

74 n the greater T cell diversity in humans and suggest a mechanism for ensuring that any V-J gene combi

75 More generally, our results suggest a mechanism for extracting and encoding temporal

76 ructural element in myosin force sensing and suggest a mechanism for generating diversity of function

77 are altered during late pregnancy and might suggest a mechanism for higher birth weight in obese wom

78 Together, these observations suggest a mechanism for HIRA-mediated H3.3/H4 deposition

79 These data suggest a mechanism for how centriolar satellites can sp

80 These results suggest a mechanism for how Kif15 rescues bipolar spindl

81 These results suggest a mechanism for how predictive perception can be

82 Our results suggest a mechanism for increased CELF1 expression downr

83 e so-called missing heritability of HSCR and suggest a mechanism for increased HSCR incidence in chil

84 These findings suggest a mechanism for instrumental action control thro

85 These results suggest a mechanism for integrative control over GCK act

86 Our results suggest a mechanism for intrauterine transmission in whi

87 The structures suggest a mechanism for iron mineral formation at the pr

88 g expression of ethanol-induced aversion and suggest a mechanism for its role in modulating escalatio

89 Collectively, our results suggest a mechanism for LD formation in C. reinhardtii i

90 Our findings suggest a mechanism for lipid mobilization that circumve

91 new structures of the bacterial YidC, which suggest a mechanism for membrane insertion by this famil

92 Our results suggest a mechanism for nascent substrate protein recogn

93 These results are the first to suggest a mechanism for opioid effects on cancer outcome

94 ng, together with these structural insights, suggest a mechanism for pore assembly for lysenin.

95 Our findings suggest a mechanism for posttranscriptional noise genera

96 The structures presented here suggest a mechanism for processivity of the holoenzyme a

97 ir observed enrichment in +1 nucleosomes and suggest a mechanism for selective control of gene expres

98 These results suggest a mechanism for size-based organelle positioning

99 These findings suggest a mechanism for sleep loss to increase risk of A

100 Taken together, these findings suggest a mechanism for targeting dendritic cargo direct

101 resentation of action units in the brain and suggest a mechanism for the analysis of large numbers of

102 These structures suggest a mechanism for the control of constitutive sign

103 Our findings suggest a mechanism for the coupling of structural dynam

104 DUSP6-ERK5 axis in melanoma tumor growth and suggest a mechanism for the development of drug-resistan

105 Our results suggest a mechanism for the direct recognition of effect

106 Our results suggest a mechanism for the emergence of primordial enzy

107 These results suggest a mechanism for the empirical functional changes

108 These results suggest a mechanism for the neuropathogenesis induced by

109 The structure and binding studies suggest a mechanism for the oncogenic inhibition of H3K2

110 labelling for utrophin and beta-dystroglycan suggest a mechanism for the protective effect of MuSK in

111 Taken together, these data may suggest a mechanism for the regulated processing of YME1

112 tional switches and biased dephosphorylation suggest a mechanism for the selective recruitment of cis

113 gulate gene expression in an animal and thus suggest a mechanism for the transmission of experience-d

114 evolution of these Ni3 C nanostructures, we suggest a mechanism for their formation.

115 These data suggest a mechanism for transcription-coupled DNA target

116 These results suggest a mechanism for tremor generation under cerebell

117 BiP observed in the calcium-depleted ER and suggest a mechanism for tuning ER quality control and co

118 t composition for memory destabilization and suggest a mechanism for why some memories are resistant

119 cision is found to contact N3 and N4 of caC, suggesting a mechanism for acid-catalyzed base excision

120 tructure interact leading to DNA compaction, suggesting a mechanism for axial filament formation.

121 on of cytoplasmic LRRs and the channel pore, suggesting a mechanism for channel gating by internal st

122 -interacting surface to regulate mRNA export suggesting a mechanism for coupling transcription initia

123 e-nucleotide substitutions in the RdRp gene, suggesting a mechanism for de novo gene creation within

124 rent copulatory damage to the female intima, suggesting a mechanism for entry of seminal proteins, or

125 Response kinetics vary by concentration, suggesting a mechanism for establishing preferences.

126 ion forks by limiting CMG helicase activity, suggesting a mechanism for fork stabilization by the rep

127 in homozygous and heterozygous mutant eyes, suggesting a mechanism for foxc1a upregulation when its

128 mutant bound GINS in the presence of Dpb11, suggesting a mechanism for how GINS is recruited to Mcm2

129 he polyQ become largely unstructured-thereby suggesting a mechanism for how N17 regulates Htt aggrega

130 inding to Set8 through this basic extension, suggesting a mechanism for how nucleosome binding protec

131 627 domains of the asymmetric FluPolA dimer, suggesting a mechanism for how the adaptive PB2(E627K) m

132 eus spp. into an indigenous cryptic plasmid, suggesting a mechanism for interspecies genetic exchange

133 concentrations previously regarded as safe, suggesting a mechanism for its observed idiosyncratic ef

134 pore expansion during membrane penetration, suggesting a mechanism for lipid factor requirement of B

135 cape of long-range chromosomal interactions, suggesting a mechanism for long-range expression QTLs.

136 ound in astrocytes isolated from these mice, suggesting a mechanism for low GnRH/luteinizing hormone

137 cations for polarocrypsis in the open ocean, suggesting a mechanism for natural selection to shape re

138 on is sufficient to induce Atoh1 expression, suggesting a mechanism for priming the 3' Atoh1 autoregu

139 ll apoptosis in gastric cancer pathogenesis, suggesting a mechanism for prolonged epithelioid tumor c

140 n with histone H3 tails, but not histone H4, suggesting a mechanism for recruitment of the NuRD compl

141 as9 from its apo form to the RNA-bound form, suggesting a mechanism for RNA recruitment in which the

142 with the two integrase active sites of Cas1, suggesting a mechanism for substrate handoff following p

143 e substantia nigra pars reticulata (SNr) and suggesting a mechanism for the cannabinoid-related slown

144 depolarizing but inhibitory in 8.5 mM K(+), suggesting a mechanism for the effects of alpha4betadelt

145 droplet is observed with a few femtoseconds, suggesting a mechanism for the gas to particle conversio

146 hat CXCR3 variant function is not redundant, suggesting a mechanism for tissue specific biased agonis

147 aste cells of an acid-sensitive K(+) channel suggests a mechanism for amplification of sour taste and

148 It suggests a mechanism for associating landmarks to or dis

149 dult glia, inhibitory synapses, and behavior suggests a mechanism for chronic maternal IL-17 effects

150 A17s and GluN2B-containing receptors to AIIs suggests a mechanism for differential modulation of exci

151 nferring receptor binding and tropism, which suggests a mechanism for efficient virus neutralization

152 This suggests a mechanism for how scaffolding proteins can al

153 in a fuzzy chaperone-substrate ensemble and suggests a mechanism for Hsp70 function whereby the stru

154 The analogy immediately suggests a mechanism for learning through evolution: ada

155 This suggests a mechanism for making rational choices despite

156 motor at the center of the particle further suggests a mechanism for mediating conformational change

157 e of Ndc80 and Ska complexes on microtubules suggests a mechanism for metazoan kinetochores to couple

158 in adjacent regions of the BCL2 P1 promoter suggests a mechanism for precise regulation of BCL2 gene

159 s interspecific social behavioral plasticity suggests a mechanism for rapid adaptation of belowground

160 in the flexible portion of the loop sequence suggests a mechanism for regioselectivity through Dio ty

161 model explains key experimental findings and suggests a mechanism for regulating both the mean and fl

162 red primary gingival epithelial cells, which suggests a mechanism for systemic consequences of period

163 dles during stimulation of the best contacts suggests a mechanism for the observed transient "depress

164 binding to isolated calmodulin domains/lobes suggests a mechanism for the role of CFTR as a molecular

165 Our biochemical analyses suggest a mechanism in coral which differs from that of

166 Density functional theory calculations suggest a mechanism in which hydrogen dissociation and p

167 In conclusion, our results suggest a mechanism in which MEF2 transcriptional activi

168 We suggest a mechanism in which the JC templates IgA oligom

169 We suggest a mechanism in which Unc-104 is particularly imp

170 ly 33 A across an extensive dimer interface, suggesting a mechanism in which polyhydroxybutyrate bios

171 guided mutants at the sensor-pore interfaces suggests a mechanism in which direct interaction between

172 ity, nor displaced of CsA from CypD protein, suggesting a mechanism independent of CypD inhibition.

173 gulated ERBB3 while re-activating pAkt T308, suggesting a mechanism independent of NRG1-ERBB3 but lik

174 Together, these data suggest a mechanism involving altered hedonic state and

175 The studies suggest a mechanism involving an iron(III)-peroxynitrite

176 Our findings therefore suggest a mechanism involving antagonistic activity of X

177 variant threonine in A152T tau toxicity and suggest a mechanism involving impaired retrograde axonal

178 Theoretical studies suggest a mechanism involving Lewis acid promoted insert

179 , and spectroscopic (UV-vis and EPR) studies suggest a mechanism involving metal-substrate complexati

180 Experimental and computational studies suggest a mechanism involving PCET, formation and reacti

181 ndicate that CASP8 might be the target gene, suggesting a mechanism involving apoptosis.

182 for the suppression of dendritic branching, suggesting a mechanism involving gene expression.

183 ghlights novel roles for Shot in mitosis and suggests a mechanism involving Dynein/Dynactin activatio

184 The separability and stability suggest a mechanism-linear summation over static synapti

185 onstrate that HAP2 is the gamete fusogen and suggest a mechanism of action akin to viral fusion, indi

186 l and functional analysis have allowed us to suggest a mechanism of action for the selective inhibiti

187 The data suggest a mechanism of action independent of the etiolog

188 pin a molecular basis for pore formation and suggest a mechanism of action that extends beyond membra

189 These properties suggest a mechanism of efficient acquisition of genic DN

190 These findings suggest a mechanism of induced fit upon ligand binding b

191 resolution which allows us using docking to suggest a mechanism of interaction between compound 187

192 These observations suggest a mechanism of Legionnaires' disease pathogenesi

193 Together, our results suggest a mechanism of macrolide-lincosamide resistance

194 Together, the data suggest a mechanism of phototropin-independent infloresc

195 These data suggest a mechanism of pneumonia-induced extrahepatic vi

196 Overall, our results suggest a mechanism of stepwise changes in ESCRT-III fil

197 These findings suggest a mechanism of transcriptional regulation during

198 al unique features of mammalian V-ATPase and suggest a mechanism of V1-Vo torque transmission.

199 ted Aedes aegypti mosquitoes, these findings suggest a mechanism of viral immune evasion at the very

200 The structure suggested a mechanism of base selection relying on Loop1

201 pled with publicly available microarray data suggested a mechanism of impaired PLGA degradation and i

202 ) 2/TM3 at the G-protein-coupling interface, suggesting a mechanism of engaging G-proteins that may h

203 e role of this protein in RNA metabolism and suggesting a mechanism of genome maintenance that depend

204 l role of PVH neurons in feeding inhibition, suggesting a mechanism of indirect action.

205 PVM that express Ki-67 and are SIV-infected, suggesting a mechanism of macrophage accumulation in the

206 with coherent vibrations of the 2D lattice, suggesting a mechanism of phonon-assisted charge transfe

207 has a strong influence on rNMP distribution, suggesting a mechanism of rNMP accommodation by DNA poly

208 oth chemokines having virtually the same Kd, suggesting a mechanism of signal amplification in DCs re

209 s showed larger increases in sensory cortex, suggesting a mechanism of susceptibility.

210 lating with NF-kappaB nuclear translocation, suggesting a mechanism of tolerance.

211 e RasC binds to the catalytic domain of TOR, suggesting a mechanism of TORC2 activation that is simil

212 spike timing synchrony across the population suggests a mechanism of active inhibition underlying thi

213 This suggests a mechanism of coordination between cells, prev

214 on between host skin peptides and microbiota suggests a mechanism of host-directed symbiosis througho

215 sustain colonization during inflammation and suggests a mechanism of how interphylum iron metabolism

216 remained largely unchanged in these mice, it suggests a mechanism of mTORC1 activation by ERK1/2 in a

217 The present study suggests a mechanism of p62 phase condensation by a prot

218 nzyme with an active site configuration that suggests a mechanism of phosphodiester hydrolysis by a m

219 The location of the region suggests a mechanism of temperature-dependent gating of

220 The model suggests a mechanism of viral adaptation by antigenic co

221 DFT calculations suggest a mechanism proceeding via nucleophilic attack o

222 ion, but phage DNA replication is prevented, suggesting a mechanism reminiscent of superinfection exc

223 ounded by locally decreased broadband power, suggesting a mechanism synchronizing cortical, thalamic,

224 ng occurs along a vectorial pathway and also suggest a mechanism that chaperones may exploit to preve

225 The structures suggest a mechanism that couples H+ flux to substrate re

226 These results suggest a mechanism that electrostatically couples the e

227 Our results suggest a mechanism that excess hemin of beta-thalassaem

228 ur understanding of IAV-induced shutoff, and suggest a mechanism that facilitates the translation of

229 These results suggest a mechanism that involves swapping of an intramo

230 ructural timeline for ILY pore formation and suggest a mechanism that is relevant to understanding ot

231 These findings suggest a mechanism that links the identity of the G12X

232 These results suggest a mechanism that links top-down prior informatio

233 These results suggest a mechanism that links top-down prior informatio

234 risk and risk variants, and our observations suggest a mechanism that may explain the very different

235 Our results suggest a mechanism that prevents inadvertent CMG destru

236 the thin filament before statically binding, suggesting a mechanism that involves a weak-binding mode

237 of MAP7 is responsible for branch formation, suggesting a mechanism that is independent of its known

238 ia the COP1/SPA E3 ubiquitin ligase complex, suggesting a mechanism that maintains low HY5 in the dar

239 E-P aggregates spanning large neighborhoods, suggesting a mechanism that stabilizes enhancer contacts

240 plant MPKs as protein kinase inhibitors and suggest a mechanism through which guard cell CO2 signali

241 Our studies suggest a mechanism through which the structure, functio

242 tially modulate interneuron excitability and suggest a mechanism through which this occurs in silico

243 following rewards in alcohol-consuming rats, suggesting a mechanism through which adolescent alcohol

244 xpressing mutant, but not wild-type, PDGFRA, suggesting a mechanism through which the oncogenic activ

245 ector of cytokine-induced IKKbeta signaling, suggesting a mechanism through which the tumor microenvi

246 Activation in the ventral visual circuitry suggests a mechanism through which signals of social app

247 These results suggest a mechanism to control organization, morphology,

248 he role of autophagy in YAP/TAZ biology, and suggest a mechanism to coordinate transcriptional rewiri

249 These results suggest a mechanism to delay ILV budding while cargoes u

250 The results suggest a mechanism to distinguish signaling responses t

251 Our studies suggest a mechanism to establish functional differentiat

252 Our results suggest a mechanism to establish RXR therapeutic targets

253 We also suggest a mechanism to help explain social collapses wit

254 nd activation in naive CD8(+) T cells, which suggest a mechanism to overcome anergy induction by the

255 ating GPCR recycling from bulk recycling and suggest a mechanism to tune downstream responses of GPCR

256 esion but can bind to individual chromatids, suggesting a mechanism to enable formation of asymmetric

257 ts increases Hsp90 binding to its inhibitor, suggesting a mechanism to enhance the efficacy of Hsp90

258 ed in precise proportions over a short time, suggesting a mechanism to ensure a reproducible outcome.

259 Aicda) and termination (Socs1/p53 response), suggesting a mechanism to explain the quantitative defec

260 eneity was observed at individual promoters, suggesting a mechanism to generate gene- and stress-spec

261 ntially higher affinity than wild-type Mcm4, suggesting a mechanism to recruit Dpb11 to DDK-phosphory

262 ndon progenitor number in the perichondrium, suggesting a mechanism to regulate attachment location.

263 irectional movement of proteasomes in axons, suggesting a mechanism to regulate loading of proteasome

264 This suggests a mechanism to restrain proliferation at steady

265 tion, proliferation, and differentiation and suggest a mechanism underlying the improved cardiac rege

266 ation of CBX2-PRC1 subunits depends on CBX2, suggesting a mechanism underlying the assembly of CBX2-P

267 e NMJs suffered limited level of remodeling, suggesting a mechanism utilized by NMJs in dry season to

268 These findings also suggest a mechanism via which anthropogenic climate chan

269 ally the neurovirulence factor, ICP34.5) and suggest a mechanism (via ICP4) for the transition from l

270 DFT calculations suggest a mechanism where divergence to the two products

271 These data suggest a mechanism where FeP initially forms encounter

272 Our structural and biochemical data suggest a mechanism where reversible binding of the A49-

273 Taken together, our data suggest a mechanism where TRPM8, PIRT, and PIP(2) form a

274 of chromosomes reproduce changes in snHi-C, suggesting a mechanism where cohesin locally compacts ch

275 o target promoters is temperature dependent, suggesting a mechanism where temperature directly contro

276 ntermolecular dynamics and inhibitor potency suggests a mechanism where polymorphisms between genotyp

277 Our results suggest a mechanism whereby bacteria use Ras family prot

278 Collectively, these findings suggest a mechanism whereby changes in the peptide reper

279 Our data suggest a mechanism whereby ICs directly inhibit inflamm

280 These studies suggest a mechanism whereby increased adrenocortical act

281 These results suggest a mechanism whereby Mga influences pluripotent c

282 On the basis of our structural analyses, we suggest a mechanism whereby molecular interactions withi

283 These findings suggest a mechanism whereby oncogenic KRAS saturates sig

284 Our results suggest a mechanism whereby oscillatory blood glucose le

285 tation of CATC-interacting vertex triplexes, suggest a mechanism whereby the portal orchestrates proc

286 platelet granule secretion and spreading and suggest a mechanism whereby VAMP-7 links granule exocyto

287 e for capsaicin and other vanilloid ligands, suggesting a mechanism whereby chemical or thermal stimu

288 measures of context retrieval on each trial, suggesting a mechanism whereby cues trigger retrieval of

289 ls are more flexible earlier in development, suggesting a mechanism whereby neural circuits begin as

290 t RNA species accumulate within this window, suggesting a mechanism whereby Paf1 loss leads to aberra

291 nd expression of IL-17 in malignant T cells, suggesting a mechanism whereby SEA-producing bacteria pr

292 urrents in the PVN following AngII infusion, suggesting a mechanism whereby TNFR1 activation contribu

293 This work suggests a mechanism whereby an increase in the abundanc

294 Overall, our study suggests a mechanism whereby S. aureus modulates cytokin

295 This suggests a mechanism whereby SRm300/SRRM2, might influen

296 This suggests a mechanism whereby the impact of any SL signal

297 This observation suggests a mechanism whereby the mutations may work main

298 Our results suggest a mechanism wherein nanoscale buckling instabili

299 rmations with 1-2 nt fraying around the gap, suggesting a mechanism wherein Pol recognises a pre-bent

300 DFT calculations suggest a mechanism with intramolecular nucleophilic aro