ライフサイエンスコーパス: suicide gene

1 oma cells by virus-regulated expression of a suicide gene.

2 with a CD28-containing anti-SLAMF7 CAR and a suicide gene.

3 ed with mCherry, and the inducible Caspase-9 suicide gene.

4 0-fold, suggesting that it may be a superior suicide gene.

5 and a herpes simplex virus thymidine kinase suicide gene.

6 virus thymidine kinase or cytosine deaminase suicide genes.

7 several advantages over currently available suicide genes.

8 allow selection of transduced cells, whereas suicide genes allow selective deletion of administered T

9 the incorporation of an inducible caspase-9 suicide gene allowed efficient elimination of transgenic

10 Incorporation of suicide genes allows the selective destruction of allode

11 fy and to destroy tumor cells expressing the suicide gene alpha(1,3)Galactosyltransferase (alpha GT).

12 effectiveness of combination therapy using a suicide gene and cytokine genes for the treatment of met

13 term immune reconstitution did not carry the suicide gene and displayed high numbers of naive lymphoc

14 dies demonstrate the need for nonimmunogenic suicide genes and identify a strategy for detection of C

15 d herpes simplex virus thymidine kinase as a suicide gene, at different time points after sensitizati

16 ng GVHD reactions and the efficacy of HSV-tk suicide gene-based T-cell deletion.

17 ts thus show that locoregional delivery of a suicide gene by RCR vectors infused into the portal circ

18 ently deleted by using direct repeats, (iii) suicide genes can be functionally reconstituted during r

19 In addition, suicide genes can install a 'safety switch' on adoptivel

20 Therefore, (a) a lytic virus expressing a "suicide" gene can activate a prodrug; and (b) within rRp

21 T cells expressing the anti-SLAMF7 CAR plus suicide-gene construct specifically recognized SLAMF7 in

22 effects developed, and the activation of the suicide gene controlled side effects.

23 rleukin 6 (IL-6) and the bacterial metabolic suicide gene cytosine deaminase (205-IL6-CD) become high

24 After confirmation of suicide gene cytotoxicity in vitro, multifocal hepatic t

25 rpes simplex virus-thymidine kinase (HSV-tk) suicide gene delivery and treatment with ganciclovir (GC

26 Its gene therapy with the TRAIL suicide gene effectively induces apoptosis of HeLa cells

27 Finally, coexpressing a suicide gene enabled fast and efficient pharmacologic ab

28 The suicide gene encoded a dimerization domain fused to a ca

29 ablated these cells by targeting them with a suicide gene encoding herpes simplex virus thymidine kin

30 mbinant VSV (rVSV) that expressed the fusion suicide gene Escherichia coli cytosine deaminase (CD)/ur

31 ant-negative mutant rpoB gene is a potential suicide gene especially for the treatment of multidrug-r

32 d molecularly via microRNA (miRNA)-regulated suicide gene expression to enrich for specific tissues.

33 ke vhs an interesting candidate for use as a suicide gene for HIV gene therapy.

34 We have created a highly compact marker/suicide gene for T cells combining target epitopes from

35 R T cells expressing the inducible caspase 9 suicide gene (GD2-CART01).

36 The genetic modification of T cells with a suicide gene grants a mechanism of control of adverse re

37 The introduction of an inducible suicide gene has been proposed as a strategy to exploit

38 Several methods for delivery of suicide genes have been explored.

39 Suicide genes have been widely investigated for their ut

40 ly modified donor T cells with an inducible "suicide" gene have the potential to improve the safety a

41 of either reporter red florescent protein or suicide genes [herpes simplex virus-thymidine kinase (TK

42 to oocytes in transgenic mice expressing the suicide gene, herpes simplex virus thymidine kinase (HSV

43 The SV40Tag sequence and a suicide gene, herpes simplex virus thymidine kinase (HSV

44 The suicide gene, herpes simplex virus thymidine kinase (tk)

45 l T cells expressing the inducible caspase 9 suicide gene (iC9-T cells).

46 o a lentiviral backbone and secured with the suicide gene iCASP9/rimiducid system.

47 o difficulties in the development of DT as a suicide gene in cancer gene therapy, because toxicity ap

48 nction suggested that vhs could be used as a suicide gene in certain gene therapy applications.

49 ne kinase (HSV1-tk) gene is widely used as a suicide gene in combination with ganciclovir (GCV) and a

50 1) thymidine kinase (TK) is widely used as a suicide gene in combination with ganciclovir.

51 hymidine kinase (HSV-tk) is widely used as a suicide gene in experimental gene therapy of cancer.

52 DeltaCD34-tk is an attractive candidate as a suicide gene in man because of the ensured expression of

53 rpes simplex virus-thymidine kinase (HSV-tk) suicide gene in mouse mammary adenocarcinoma (TSA) cells

54 we assessed the efficacy of the DeltaCD34-tk suicide gene in the absence of extended ex vivo manipula

55 the transduction and regulation of a double suicide gene in tumor cells and may provide a unique app

56 city can be accomplished by RIP coupled to a suicide gene in vivo, preventing hypoglycemic death.

57 We recently constructed a novel chimeric suicide gene in which the entire coding region of HSV th

58 ancer gene therapy by selectively expressing suicide genes in cancer cells and not normal cells.

59 ified MSCs to stably express a panel of four suicide genes including TK (TK007 and TK(SR39) mutants),

60 ed: a retroviral construct incorporating the suicide gene inducible caspase-9 (CD19-CAR-Retro_ALLO) f

61 reacting T cells by T cell subset selection, suicide gene insertion or selective allodepletion, and t

62 Thus, Cas9-mediated suicide-gene insertion may be a viable genotype-specific

63 dly applicable to introducing therapeutic or suicide genes into patient-specific iPS cells for use in

64 l injections of a plasmid in which the HSVtk suicide gene is expressed from a melanocyte-specific pro

65 sgenic mice in which a thymidine kinase (TK) suicide gene is targeted to the T cell using a CD3 promo

66 th the herpes simplex virus thymidine kinase suicide gene linked to the IL-2 promoter were used as a

67 odel, we demonstrate that early-intervention suicide-gene-mediated senescent cell ablation improves p

68 The elimination of senescent cells by suicide gene-meditated ablation of p16(Ink4a)-expressing

69 We conclude that a suicide gene of pneumococcus is spxB, which induces an a

70 The HSV1-TK enzyme can act as a suicide gene of transduced cells through treatment with

71 SC elimination by suicide gene or ABT263 increased the right ventricular s

72 SC clearance was obtained by a suicide gene (p16 promoter-driven killer gene construct

73 d carrier to deliver the inducible caspase-9 suicide gene (pLVSIN-iC9) into breast cancer cells.

74 clusion, the insertion of the fusion CD/UPRT suicide gene potentiates the oncolytic efficiency of VSV

75 r stomatitis virus (VSV) able to produce the suicide gene product thymidine kinase (TK) or cytokine i

76 of the mutants make them good candidates for suicide-gene/protein-therapy applications.

77 rpes simplex virus thymidine kinase (HSV-TK) suicide gene protocols has resulted in enhanced antitumo

78 and herpes simplex virus-1 thymidine kinase suicide genes render malignant cells sensitive to specif

79 Replacement of the reporter gene with a suicide gene resulted in selective killing of SW480 cell

80 cell therapy, such as the incorporation of a suicide gene safety system.

81 The use of any of these mutants as a suicide gene should provide a more effective and safer a

82 estes antigen NY-ESO-1, coexpressing the PET/suicide gene sr39TK.

83 e reconstitution associated with a different suicide gene strategy to abrogate graft-versus-host dise

84 The introduction of an inducible suicide gene such as the herpes simplex virus thymidine

85 of direct viral oncolysis to the HSV-tk/GCV suicide gene system resulted in a striking improvement i

86 Inducible suicide gene systems, often viewed solely as safety mech

87 A compact marker/suicide gene that utilizes established clinical-grade re

88 divided into four main areas: 1) transfer of suicide genes that convert inactive prodrugs into cytoto

89 cancer, one improvement would be to develop suicide genes that effectively kill both dividing and no

90 in which tumor cells are transfected with a 'suicide' gene that encodes a metabolic enzyme capable of

91 Prior transduction of T lymphocytes with the suicide gene, the viral thymidine kinase (TK), permits s

92 tween the oncolytic adenovirus and/or double-suicide gene therapies and radiation therapy.

93 Suicide gene therapies provide a unique ability to targe

94 ductase enzyme (NTR) has been widely used in suicide gene therapy (GDEPT and ADEPT) applications as a

95 They are self-immolative prodrugs for suicide gene therapy activation by the enzyme carboxypep

96 Cancer suicide gene therapy affords the prospect of using the m

97 , this cytokine approach was combined with a suicide gene therapy and subcutaneous B16 melanomas were

98 sent the findings on improved techniques for suicide gene therapy and various oncolytic viral therapi

99 We designed a novel suicide gene therapy approach wherein the gene product (

100 In an effort to optimize this suicide gene therapy approach, we have determined the th

101 x virus type 1 (HSV-1) thymidine kinase (TK) suicide gene therapy as a potential antitumor treatment.

102 this attribute could be exploited in cancer suicide gene therapy by using a lentiviral (LV) vector e

103 ication-competent adenovirus-mediated double-suicide gene therapy can be combined safely with convent

104 hypothesis that the effectiveness of HSV-TK suicide gene therapy can be enhanced by coexpression of

105 deficiencies, chronic granulomatous disease, suicide gene therapy for graft-versus-host disease, vira

106 d HVP22 to enhance Etk/ganciclovir (Etk/GCV) suicide gene therapy for neuroblastomas by GCV cytotoxic

107 Clinical experience with suicide gene therapy for prostate cancer using first-gen

108 utic potential of BVP22 and HVP22 in Etk/GCV suicide gene therapy in this tumor system is not due to

109 Suicide gene therapy is one approach being evaluated for

110 emonstrate that CID-regulated, caspase-based suicide gene therapy is safe and can inhibit the growth

111 One example of suicide gene therapy is the bacterial nitroreductase (NT

112 Suicide gene therapy may contribute to the treatment of

113 Adenovirus-mediated suicide gene therapy may hold promise in the treatment o

114 Suicide gene therapy of cancer is a method whereby cance

115 e cell-based, non-viral or viral vectors for suicide gene therapy of cancer make more informed decisi

116 B1954) have been used for stem cell mediated suicide gene therapy of cancer.

117 evelop a stem cell-based system for targeted suicide gene therapy of recurrent, metastatic, and unres

118 ible to utilize such nucleoside analogues in suicide gene therapy or protein therapy applications tha

119 or obstacle to the successful application of suicide gene therapy strategies that rely on in situ tra

120 in combination with the pro-drug CB1954 in a suicide gene therapy strategy.

121 We have designed a targeted systemic suicide gene therapy that combines the advantages of tum

122 evaluated the safety and efficacy of a novel suicide gene therapy that could potentially spare normal

123 fferences have been exploited in a potential suicide gene therapy treatment for solid tumors.

124 Suicide gene therapy using the cytosine deaminase (CD) g

125 with established liver metastases show that suicide gene therapy using TK- vaccinia virus as a vecto

126 Suicide gene therapy using vv with the CD/5-FC system le

127 Thus, telomerase-specific suicide gene therapy vectors expressing bacterial nitror

128 In a mouse xenograft model of lung cancer, suicide gene therapy with LV-ARE-TK/GCV was effective co

129 Suicide gene therapy with the herpes simplex virus thymi

130 udied antiglioma gene therapy strategies are suicide gene therapy, genetic immunotherapy and oncolyti

131 est the potential therapeutic efficacy of DT suicide gene therapy, we first developed a DT-resistant

132 Using HSVtk suicide gene therapy, we showed that macrophages can dis

133 d molecular imaging agents targeting HSV1-tk suicide gene therapy.

134 nic alternative modality for prostate cancer suicide gene therapy.

135 ndidate for anti-microbial drug development, suicide-gene therapy, and cell-specific mRNA labeling te

136 Insulinoma-specific cytotoxicity using the suicide gene thymidine kinase (tk) was studied both in v

137 T cells expressing the HSV thymidine kinase suicide gene (TK+ cells).

138 approach likely requires the inclusion of a suicide gene to deal with the potential development of T

139 neered human CAF cell line with an inducible suicide gene to enable selective in vivo elimination of

140 bination of tumor killing by activation of a suicide gene to release tumor antigens and in situ HSP70

141 h donor T cells expressed a thymidine kinase suicide gene, to test whether separation of GVL and graf

142 . injection of plasmids encoding hsp70 and a suicide gene transcriptionally targeted to melanocytes g

143 st disease include CD4 lymphocyte infusions, suicide gene-transfected cells, and the use of cloned T

144 aft-versus-host disease may be controlled by suicide gene transfection of the donor lymphocytes.

145 r data suggest that the HSV-tk/GCV metabolic suicide gene transfer system could serve as an adjuvant

146 In situ killing of tumor cells using suicide gene transfer to generate death by a non-apoptot

147 Here we have developed an in vivo HSP-suicide gene tumor vaccine by generating a recombinant r

148 road relevance to the use of the in vivo HSP/suicide gene tumor vaccine in therapy for human solid tu

149 ful for positive T-cell selection and (2) a "suicide" gene useful for elimination of transfected T ce

150 erpes simplex virus-thymidine kinase (HSVtk) suicide gene, using a murine fibrosarcoma model, in the

151 In 1 patient, the suicide gene was activated, with rapid elimination of GD

152 eated cells that express an NF-kappaB-driven suicide gene, we discovered that the LPS receptor Toll-l

153 pes simplex virus thymidine kinase (HSV-TK) "suicide gene," we demonstrate Smad4-responsive regulatio

154 certain viral infections, the inclusion of a suicide gene with an anti-SLAMF7 CAR is prudent.