ライフサイエンスコーパス: sulfotransferase

1 Xanthomonas oryzae pv. oryzae, is a tyrosine sulfotransferase.

2 mmobilized HS chain using D-glucosaminyl 3-O-sulfotransferase.

3 racterize the Drosophila heparan sulfate 2-O-sulfotransferase.

4 similarity to vertebrate heparan sulfate 2-O-sulfotransferase.

5 imerase, heparan 6O-sulfotransferase, and 2O-sulfotransferase.

6 e oxidase, catechol O-methyltransferase, and sulfotransferase.

7 rate selection by SULT2A1 and possibly other sulfotransferases.

8 se/N-sulfotransferases and heparan sulfate O-sulfotransferases.

9 s encoding specific glycosyltransferases and sulfotransferases.

10 g heparan sulfate N-sulfotransferase and 6-O-sulfotransferases.

11 the least sequence conservation between TEG sulfotransferases.

12 ferases, heparan sulfate C(5)-epimerase, and sulfotransferases.

13 its homology to vertebrate glycosaminoglycan sulfotransferases.

14 producing the obligatory cosubstrate for all sulfotransferases.

15 brid N-glycans that especially interact with sulfotransferases.

16 fotransferase (KSGal6ST) and chondroitin 6-O-sulfotransferase 1 (C6ST-1).

17 ied with 4-linked sulfate by either GalNAc-4-sulfotransferase 1 (GalNAc-4-ST1) (CHST8) or GalNAc-4-ST

18 ce deficient in both N-acetylglucosamine-6-O-sulfotransferase 1 (GlcNAc6ST-1) and GlcNAc6ST-2 and fou

19 Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) is one of several specialize

20 Reduced HS 6-O-sulfotransferase 1 (HS6ST-1) or 6-O-sulfotransferase 2 (

21 We report here mutations in HS 6-O-sulfotransferase 1 (HS6ST1) in families with idiopathic

22 (HS) modifying enzyme GlcNAc N-deacetylase/N-sulfotransferase 1 (Ndst1) exhibit severe developmental

23 the biosynthetic gene GlcNAc N-deacetylase/N-sulfotransferase 1 (Ndst1) in hepatocytes using the Cre-

24 ulfate biosynthetic gene N-deacetylase and N-sulfotransferase 1 (Ndst1) in murine hepatocytes (Ndst1

25 we generated mice lacking Golgi-associated N-sulfotransferase 1 (Ndst1) that catalyzes sulfation of H

26 N-acetylglucosamine (GlcNAc) N-deacetylase-N-sulfotransferase 1 (Ndst1).

27 ith the levels of the enzyme N-deacetylase/N-sulfotransferase 1 (NDST1).

28 c enzyme N-acetylglucosamine N-deacetylase/N-sulfotransferase 1 (Ndst1).

29 and decreased or absent heparan sulfate 2-O-sulfotransferase 1 in two of three fibroblast cell lines

30 y in planta co-expression of tyrosyl protein sulfotransferase 1, we installed O-sulfated tyrosine in

31 Here we demonstrate that HS 6-O-sulfotransferases 1 and 2 (HS6ST-1 and HS6ST-2), which p

32 the two CS synthetic enzymes chondroitin 4-O-sulfotransferase-1 (C4ST-1/CHST11) and chondroitin 6-O-s

33 ferase-1 (C4ST-1/CHST11) and chondroitin 6-O-sulfotransferase-1 (C6ST-1/CHST3) suppressed cell viabil

34 r sulfate addition to GalNAc on LH, GalNAc-4-sulfotransferase-1 (GalNAc-4-ST1) in mice.

35 Mice deficient in N-acetylglucosamine-6-O-sulfotransferase-1 (GlcNAc6ST-1) failed to synthesize su

36 ransferase (Hs2st(f/f)) and glucosaminyl 6-O-sulfotransferase-1 (Hs6st1(f/f)) and the bacterial Cre r

37 ivation of the gene encoding N-deacetylase/N-sulfotransferase-1 (Ndst1), a key enzyme involved in the

38 mpted targeting of lymphatic N-deacetylase/N-sulfotransferase-1 (Ndst1), a major sulfate-modifying he

39 hat the sulfation activity of tyrosylprotein sulfotransferase-1 (TPST-1) is required for Xenopus dors

40 d at position 21 by expressed tyrosylprotein sulfotransferase-1 and unmodified peptide are both disor

41 ted a conditional allele for N-deacetylase/N-sulfotransferase-1 by using Cre-loxP technology.

42 Mammary tumor cells lacking N-deacetylase/N-sulfotransferase-1 exhibited reduced toxoplasma infectiv

43 lfation of HS resulting from elevated HS 6-O-sulfotransferase-1 expression in IPF HLF accounted, in p

44 enzyme N-acetyl glucosamine N-deacetylase-N-sulfotransferase-1 in endothelial cells and leukocytes,

45 In Hs3st1(-/-) (HS 3-O-sulfotransferase-1 knockout) cells, reduced 3-O-S levels

46 -4-sulfotransferase-1, but not of dermatan-4-sulfotransferase-1, accelerates regeneration of zebrafis

47 heparan sulfate initiated by N-deacetylase/N-sulfotransferase-1, but 2-O sulfation and 6-O sulfation

48 Knockdown of chondroitin-4-sulfotransferase-1, but not of dermatan-4-sulfotransfera

49 d invasion were unchanged in N-deacetylase/N-sulfotransferase-1-inactivated cells as well, but replic

50 n, we studied the effect of chondroitin 4- O-sulfotransferase-1/carbohydrate sulfotransferase-11 (C4S

51 ferase-11 (C4ST-1/Chst-11) and dermatan 4- O-sulfotransferase-1/Chst-14 (D4ST-1/Chst-14) down-regulat

52 subjected to enzymatic modifications by 3-O-sulfotransferases-1 (3-OST1) to provide 3-O-sulfated der

53 re, we identified and validated carbohydrate sulfotransferase 10 (CHST10) as a novel RARgamma target

54 allele and the carbohydrate (chondroitin 4) sulfotransferase 11 (CHST11) locus at 12q23, with a reci

55 droitin 4- O-sulfotransferase-1/carbohydrate sulfotransferase-11 (C4ST-1/Chst-11) and dermatan 4- O-s

56 s to serve as substrates for human cytosolic sulfotransferase 1A1 (hSULT1A1) was assessed by OH-PCB-d

57 DP-glucuronosyltransferase (UGT), and phenol sulfotransferase 1A1 (SULT1A1) were measured in brain of

58 P4501A2 (CYP1A2), N-acetyltransferase 2, and sulfotransferase 1A1 enzyme activity.

59 m-specific inhibitors of the human cytosolic sulfotransferase 1A3 (SULT1A3)-the isoform responsible f

60 ensively sulfonated and inactivated by human sulfotransferase 1A3 (SULT1A3).

61 Cytosolic sulfotransferase 1C3 (SULT1C3) is the least characterize

62 pha) phosphorylation plays a pivotal role in sulfotransferase 1E1 gene regulation within mouse liver.

63 show that heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2 (HS3ST-2) is a marker for specific su

64 d HS 6-O-sulfotransferase 1 (HS6ST-1) or 6-O-sulfotransferase 2 (HS6ST-2) expression in endothelial c

65 Tyrosylprotein sulfotransferase 2 (TPST2) and solute carrier family 35

66 Here, we report that 2-O-sulfotransferase (2-OST) is an essential component of ca

67 hemopoietic PGD(2) synthase, N-deacetylase/N-sulfotransferase-2 (enzyme involved in heparin biosynthe

68 ncreased expression of bile acid-detoxifying sulfotransferase 2A (Sult2a) and selected bile acid tran

69 ), UDP-glucuronosyltransferase 1a1 (Ugt1a1), sulfotransferase 2a1 (Sult2a1), and organic anion-transp

70 HS 2-O-sulfotransferase (2OST) is a key enzyme in this pathway.

71 le specialized sulfotransferases such as 2-O-sulfotransferase (2OST) that transfers the sulfo group t

72 HS 2-O-sulfotransferase (2OST) transfers the sulfo group to the

73 ) heparan sulfate (HS)-generating enzyme 3-O sulfotransferase 3 (3-OST-3) but not nectin-1 or nectin-

74 We identified carbohydrate sulfotransferase 3 (CHST3), an enzyme that catalyzes pro

75 pathophysiological significance for the 3-O-sulfotransferase 3-OST3A (HS3ST3A), catalyzing the final

76 d demonstrate the clinical value of the HS-O-sulfotransferase 3-OST3A as a prognostic marker in HER2+

77 3-O-Sulfation of HS is catalyzed by the 3-O-sulfotransferase (3-OST) enzyme.

78 The 3-O-sulfotransferase (3-OST) family catalyzes rare modificat

79 mine residues in heparan sulfate (HS) by 3-O-sulfotransferase (3-OST) is a key substitution that is p

80 Heparan sulfate 3-O-sulfotransferase (3-OST) is an enzyme that transfers a s

81 First, 3-O-sulfotransferase-3 (3-OST-3) expression in HIS cells pro

82 se genes, heparan sulfate d-glucosaminyl 3-O-sulfotransferase 3A1 and hyaluronan synthase 2, are also

83 tidase 2, heparan sulfate d-glucosaminyl 3-O-sulfotransferase 3A1, and hyaluronan synthase 2) that ha

84 ated by heparan sulfate (HS) glucosamine 3-O-sulfotransferase 3B1 (HS3ST3B1).

85 plicated in human PE, encoding Galactose-3-O-sulfotransferase 4.

86 and synaptic activity.SIGNIFICANCE STATEMENT Sulfotransferase 4A1 (SULT4A1) is a brain-specific sulfo

87 Sulfotransferase 4A1 (SULT4A1) is a cytosolic sulfotrans

88 erred to as rs752084147, in the Carbohydrate Sulfotransferase 9 (CHST9) gene, was detected in two fam

89 to be the only C. elegans cytosolic alcohol sulfotransferase, a family of enzymes that catalyze a su

90 l of the protease cascade relies on the Pipe sulfotransferase, a fly homolog of vertebrate glycosamin

91 Here, we report that O-sulfotransferases, a class of enzymes that modify hepara

92 T carrying mutations of these residues lacks sulfotransferase activity and the ability to bind 3'-pho

93 of bacterially expressed SSU-1 demonstrates sulfotransferase activity and thus confirms the function

94 tations at these residues led to the loss of sulfotransferase activity but maintained the ability to

95 This work demonstrates sulfotransferase activity in C. elegans and indicates th

96 thelium can support the requirement for Pipe sulfotransferase activity in embryonic DV patterning.

97 cation of a gene, lpsS, which encodes an LPS sulfotransferase activity in S. meliloti.

98 mechanism through which spatially restricted sulfotransferase activity in the developing egg chamber

99 cking LpsS displayed an 89% reduction in LPS sulfotransferase activity in vitro.

100 regulator of HS-sulfation, increasing the N-sulfotransferase activity of HS-modifying N-deacetylase/

101 that embryonic DV polarity depends upon the sulfotransferase activity of Pipe.

102 O-sulfation in a C41C4.1 mutant and in vitro sulfotransferase activity of recombinant C41C4.1 protein

103 by sulfate esters, consistent with bacterial sulfotransferase activity.

104 propose to name lpsS), which encodes an LPS sulfotransferase activity.

105 wed by modifications using heparan sulfate N-sulfotransferase and 6-O-sulfotransferases.

106 sed on their structural homology to estrogen sulfotransferase and HS 3-O-sulfotransferase isoform 3 (

107 oduct of the gene C41C4.1 as a C. elegans CS-sulfotransferase and renamed it chst-1 (CarboHydrate Sul

108 e at LGS1 codes for an enzyme annotated as a sulfotransferase and show that functional loss of this g

109 this scheme the curacin A PKS employs tandem sulfotransferase and TE domains to form a terminal alken

110 proportion of 6-O-sulfation suggest that 6-O-sulfotransferase and/or 6-O-sulfatase enzymes may also b

111 Biosynthesis of HS involves sulfotransferases and an epimerase.

112 ncluding exostosin-2 (Ext2), N-deacetylase/N-sulfotransferases and heparan sulfate O-sulfotransferase

113 we found that the activities of only Gal 3-O-sulfotransferases and not sialyltransferases were advers

114 enzymes, glucuronyl C5-epimerase, heparan 6O-sulfotransferase, and 2O-sulfotransferase.

115 d with increased expression of HS6ST1, a 6-O-sulfotransferase, and GLCE, an epimerase that promotes 6

116 rXa21 activity if raxST, encoding a putative sulfotransferase, and raxA are provided in trans.

117 approach involving glycosyltransferases, HS sulfotransferases, and C(5)-epimerase.

118 glycosidases, nucleotide-sugar transporters, sulfotransferases, and glycan-bearing protein/lipid scaf

119 HS function is mainly controlled by sulfotransferases, and here we report a novel cellular a

120 Because the recombinant sulfotransferases are expressed in bacteria, and the met

121 Although tyrosylprotein sulfotransferases are known to exist as homodimers in th

122 Only two sulfotransferases are known to generate Gal6S, namely ke

123 GPA-modifying sulfotransferases are promising tools for generating the

124 Gal6ST and C6ST-1 to determine whether these sulfotransferases are required for the generation of end

125 identify GlyCAM-1 and high endothelial cell sulfotransferase as new IKKalpha-dependent target genes,

126 The identification of sulfotransferases as candidate genes suggests that DO mi

127 We used a newly developed sulfotransferase assay and ultraviolet photodissociation

128 we show that Drosophila melanogaster HS 3-O sulfotransferase-b (Hs3st-B), which catalyzes HS 3-O sul

129 nsferase and renamed it chst-1 (CarboHydrate SulfoTransferase) based on loss of CS-4-O-sulfation in a

130 ur data provide evidence that Pipe acts as a sulfotransferase, but argue against the hypothesis that

131 of the hormone-metabolizing enzyme estrogen sulfotransferase by certain BFRs.

132 ransferases, glutathione S-transferases, and sulfotransferases can protect cells against the toxic an

133 effects have been measured for the estrogen sulfotransferase-catalyzed sulfuryl (SO3) transfer from

134 presence of corneal N-acetylglucosamine 6-O sulfotransferase (CGn6ST).

135 reased KSPG core protein genes and galactose sulfotransferase CHST1 expressions 2-fold; and reduced K

136 They also suggested that the sulfotransferase CHST1 regulates the abundance and inten

137 te with specific functions using immobilized sulfotransferases combined with a 3'-phosphoadenosine 5'

138 glucosamine, whereas chondroitin sulfate 2-O-sulfotransferase (CS-2OST) transfers the sulfo group to

139 evels for Gal3st1 (also known as cerebroside sulfotransferase [CST]), known to play a crucial role in

140 dysmyelinated mutants including the ceramide sulfotransferase deficient (CST-/-) mouse, which are mor

141 ISPR-Cas9 screening and identified PAPST1, a sulfotransferase encoded by SLC35B2, as a host entry fac

142 ansferase 1A1, 1A3, 1A4, 1A6, hydroxysteroid sulfotransferase enzyme 2A1, multidrug resistance protei

143 ike proteins sharing regulatory roles with a sulfotransferase enzyme.

144 ase activity of HS-modifying N-deacetylase/N-sulfotransferase enzymes.

145 e report an essential role for the oestrogen sulfotransferase (EST or SULT1E1), a conjugating enzyme

146 his transfer reaction, catalyzed by estrogen sulfotransferase (EST), is investigated here in detail.

147 Estrogen sulfotransferase (EST), the enzyme responsible for the s

148 Estrogen sulfotransferase (EST, encoded by SULT1E1) catalyzes the

149 Estrogen sulfotransferase (EST/SULT1E1) is known to catalyze the

150 arin, and HS3ST3A1, another glucosaminyl 3-O-sulfotransferase expressed in cells.

151 nding cassette subfamily G member 8 [ABCG8], sulfotransferase family 2A member 1, cytochrome P450 7A1

152 ities between members of the human cytosolic sulfotransferase family correlate with small-molecule bi

153 irst example of half-sites reactivity in the sulfotransferase family.

154 tly sulfates, which indicated conjugation by sulfotransferases followed by efflux from the enterocyte

155 g modes of TBBPA and 3-OH-BDE-47 to estrogen sulfotransferase for comparison with binding of the endo

156 Using the teicoplanin aglycone and the 3 sulfotransferases found in one of these gene clusters, m

157 These experiments identified one sulfotransferase, GAL3ST3, and one glycosyltransferase,

158 d kinetic properties of three cloned Gal:3-O-sulfotransferases (Gal3STs) ST-2, ST-3, and ST-4 along w

159 olgi transmembrane N-acetylgalactosamine-4-O-sulfotransferase (GalNAc4-ST1), which we show by immunof

160 on of Ndst1, the predominant N-deacetylase/N-sulfotransferase gene essential for the formation of mat

161 SULT2B1 gene is unique among steroid/sterol sulfotransferase genes in that it encodes for two isofor

162 re, mice lacking two N-acetylglucosamine-6-O-sulfotransferases (GlcNAc6ST-1 and GlcNAc6ST-2) demonstr

163 Two HEV-expressed sulfotransferases, GlcNAc6ST-1 and GlcNAc6ST-2, are esse

164 emicals, including cytochromes P450 (P450s), sulfotransferases, glutathione transferases, and UDP-glu

165 several galactose-sulfurylases, carbohydrate-sulfotransferases, glycosyltransferases, and one family

166 Bs, including OH-PCB3s, as the substrates of sulfotransferases have not been studied in many organism

167 ransferase 4A1 (SULT4A1) is a brain-specific sulfotransferase highly expressed in neurons.

168 h substrate in the absence of a carbohydrate sulfotransferase; however, they produced extended GlcNAc

169 Heparan sulfate 2-O-sulfotransferase (HS-2OST) transfers the sulfo group fro

170 for cranial axon patterning, whilst the 2-O-sulfotransferase HS2ST (also known as HS2ST1) is importa

171 Mutant mouse embryos lacking the heparan sulfotransferases Hs2st or Hs6st1 have severe CC phenoty

172 e functions of the Drosophila HS 2-O and 6-O sulfotransferase (Hs2st and Hs6st) genes in FGF-mediated

173 vious study using Drosophila HS 2-O- and 6-O-sulfotransferase (Hs2st and Hs6st) mutants showed that l

174 xP-flanked conditional alleles of uronyl 2-O-sulfotransferase (Hs2st(f/f)) and glucosaminyl 6-O-sulfo

175 . elegans ortholog of vertebrate heparan 2-O-sulfotransferase (HS2ST) and the gene named hst-2.

176 Inactivation of heparan sulfate uronyl 2-O-sulfotransferase (Hs2st) in neutrophils substantially re

177 the biosynthetic enzyme, heparan sulfate 2-O-sulfotransferase (Hs2st) leads to kidney agenesis.

178 Because HS 2-O-sulfotransferase (Hs2st) shows a strong substrate prefer

179 HS biosynthetic enzyme, heparan sulfate 2-O sulfotransferase (Hs2st; an enzyme which catalyzes the 2

180 etically ablated heparan sulfate 2-O and 6-O sulfotransferases (Hs2st, Hs6st1, and Hs6st2) in develop

181 Simultaneous block of Hsepi and HS 6-O-sulfotransferase (Hs6st) activity disrupted tracheoblast

182 We show that the 6-O-sulfotransferases HS6ST1 and HS6ST2 are essential for cr

183 dues, which is generated by glucosaminyl-6-O-sulfotransferases (HS6STs) and selectively removed by ce

184 n of 6-O-sulfate is catalyzed by a family of sulfotransferases (HS6STs), and genetic manipulation of

185 that the HS C-5 epimerase hse-5, the HS 2-O-sulfotransferase hst-2, or the HS 6-O-sulfotransferase h

186 HS 2-O-sulfotransferase hst-2, or the HS 6-O-sulfotransferase hst-6 inhibit N-sulfation.

187 navigation phenotypes in two heparan sulfate sulfotransferase (Hst) mutant embryos, Hs2st-/- and Hs6s

188 C. elegans but also a mutant lacking two HS sulfotransferases (hst-6 hst-2), as we suspected that th

189 ified by co-expression of the human GalNAc 4-sulfotransferase I, which generates SO4-4GalNAcbeta1-4Gl

190 Here we show that inactivation of uronyl 2-O-sulfotransferase in endothelial cells (Hs2st), an enzyme

191 f Toll depends upon the activity of the Pipe sulfotransferase in the ventral region of the follicular

192 ults establish an essential function for the sulfotransferases in L-selectin ligand synthesis and may

193 Human SULT2A1 is one of two predominant sulfotransferases in liver and catalyzes transfer of the

194 The widespread role of sulfotransferases in modulating glycan function makes th

195 ps on HS, which are controlled by various HS sulfotransferases in the Golgi apparatus as well as extr

196 target genes, Chst2, encodes a carbohydrate sulfotransferase integral to glycosaminoglycan sulfation

197 PAPST1 is a sulfotransferase involved in heparan sulfate proteoglyca

198 the downregulated genes were chondroitin-4-O-sulfotransferase involved in the synthesis of chondroiti

199 an-1 and hepatocyte-specific inactivation of sulfotransferases involved in heparan sulfate biosynthes

200 for the study of sialyltransferases and 3-O-sulfotransferases involved in the biosynthesis of O-glyc

201 Typical of its family, estrogen sulfotransferase is partially k(cat)-inhibited by its ac

202 ting that neither of the known galactose 6-O-sulfotransferases is required for ligand synthesis.

203 and kinetics of the interaction between 3-O-sulfotransferase isoform 1 (3-OST-1) and HS have been ex

204 logy to estrogen sulfotransferase and HS 3-O-sulfotransferase isoform 3 (3-OST3), for which crystal s

205 saccharide (3-OH octasaccharide) with HS 3-O-sulfotransferase isoform 3.

206 HS3st1 (heparan sulfate 3-O-sulfotransferase isoform-1) is a critical enzyme involve

207 on of both HS3st1 and NDST2 (N-deacetylase/N-sulfotransferase isoform-2) afforded HS with a very low

208 cDNAs for rat SULT2B1 steroid/sterol sulfotransferase isoforms were cloned, and the encoded p

209 Mice deficient in sulfatide (cerebroside sulfotransferase knock-out, CST (-/-)) or complex gangli

210 The same vessels also expressed a GlcNAc-6-O-sulfotransferase known as HEC-GlcNAc6ST, which is known

211 Gal6S, namely keratan sulfate galactose 6-O-sulfotransferase (KSGal6ST) and chondroitin 6-O-sulfotra

212 ed a homolog of the S. meliloti carbohydrate sulfotransferase, LpsS, in Mesorhizobium loti.

213 orphisms in UDP-glucuronosyltransferases and sulfotransferases may contribute to variability in phyto

214 sequence and structural similarities, these sulfotransferases modify distinct side chains on the GPA

215 O-sulfotransferases modify heparan sulfate proteoglycans (

216 Unlike the wild type protein, 2-O-sulfotransferase mutant (2OST Y94I) transfers sulfate to

217 The glucosaminyl N-deacetylase/N-sulfotransferase (NDST) enzymes have a key role during b

218 y the action of glucosaminyl N-deacetylase/N-sulfotransferase (NDST).

219 ation of N-acetylglucosamine N-deacetylase-N-sulfotransferase (Ndst1) in endothelial cells.

220 women, indicating changes in N-deacetylase/N-sulfotransferases (NDSTs), the enzymes involved in the i

221 d at specific positions by heparan sulfate O-sulfotransferase (OST) families.

222 -47) have been suggested to inhibit estrogen sulfotransferase, potentially affecting estrogen metabol

223 form to high-toxicity forms through expanded sulfotransferases, probably as deterrence against predat

224 ediction results in the functionally diverse sulfotransferase protein family.

225 ided by plastids to serve as a substrate for sulfotransferase reactions in the cytosol and the Golgi

226 structure, we ablated the gene encoding the sulfotransferase responsible for sulfate addition to Gal

227 ession of an engineered human tyrosylprotein sulfotransferase, resulting in antigen-binding and virus

228 formation of these compounds, we studied the sulfotransferase (SOT) gene family in P trichocarpa (PtS

229 t to the limited expression of the cytosolic sulfotransferase SSU-1 in the ASJ neuron pair.

230 chain termination module containing adjacent sulfotransferase (ST) and thioesterase (TE) catalytic do

231 tructure of the ternary complex of bacterial sulfotransferase StaL with the cofactor product 3'-phosp

232 Mycobacterial carbohydrate sulfotransferase Stf0 catalyzes the sulfuryl group trans

233 sphosulfate and a previously uncharacterized sulfotransferase, stf3.

234 res provide insights into the ability of the sulfotransferase substrate binding pocket to accommodate

235 S biosynthesis involves multiple specialized sulfotransferases such as 2-O-sulfotransferase (2OST) th

236 Sulfotransferase sulfonation of beta-hydroxy-acyl-ACP is

237 CH), on thyroid hormone deiodinase (DIO) and sulfotransferase (SULT) activity were investigated using

238 The superfamily of sulfotransferase (SULT) enzymes catalyzes the sulfate co

239 d mRNA expression levels of five major human sulfotransferase (SULT) enzymes in 10 matched pericarcin

240 osomal prodrug oxamniquine is activated by a sulfotransferase (SULT) in the parasitic flatworm Schist

241 idine glucuronic acid transferase (UGT), and sulfotransferase (SULT)) in their biotransformation.

242 Cytosolic sulfotransferase (SULT)-catalyzed sulfation regulates bi

243 Cytosolic sulfotransferase (SULT)-catalyzed sulfation regulates bi

244 Cytosolic sulfotransferase (SULT)-mediated sulfation plays an esse

245 Sulfotransferase (SULT)-mediated sulfation represents a

246 hether sulfonation of PAH catechols by human sulfotransferases (SULT) could intercept the catechol in

247 ofactors of N,O-acetyltransferases (NAT) and sulfotransferases (SULT) were added to cytosolic samples

248 In primates but not lower order animals, a sulfotransferase (SULT1A3) is present that can rapidly m

249 uced the expression and activity of estrogen sulfotransferase (SULT1E1 or EST), an enzyme important f

250 n by rifampicin (RIF) represses the estrogen sulfotransferase (SULT1E1) gene in human primary hepatoc

251 Estrogen sulfotransferase (SULT1E1) inactivates estrogen and regu

252 elopment of specific substrates for estrogen sulfotransferase (SULT1E1) to produce molecular imaging

253 Estrogen sulfotransferase (SULT1E1, or EST) plays an important ro

254 PXR-mediated gene induction of the phase II sulfotransferase Sult2A1 in the livers of 4-month- and 2

255 SNPs in the hydroxysteroid sulfotransferase, SULT2A1, have been identified in Afric

256 The cholesterol sulfotransferase SULT2B1b catalyzes the sulfoconjugation

257 xcept for genes encoding aromatase (cyp19b), sulfotransferase (sult2st3), and cyp2k22 that were induc

258 allosteric regulation of the human cytosolic sulfotransferase (SULTs) family-13 disease-relevant enzy

259 Cytosolic sulfotransferases (SULTs) are phase II detoxification en

260 Human cytosolic sulfotransferases (SULTs) regulate the activities of hun

261 Human cytosolic sulfotransferases (SULTs) regulate the activities of tho

262 Acting during phase II metabolism, sulfotransferases (SULTs) serve detoxification by transf

263 Human cytosolic sulfotransferases (SULTs) transfer the sulfuryl moiety (

264 NSAIDs allosterically inhibit cytosolic sulfotransferases (SULTs) with high specificity and ther

265 dary reactive intermediate by some mammalian sulfotransferases (SULTs).

266 road-specificity enzymes-the human cytosolic sulfotransferases (SULTs).

267 roblem has now been solved for the cytosolic sulfotransferases (SULTs).

268 viii) Just like LNCaPalpha1,2-FT and Gal-3-O-sulfotransferase T2, the cloned alpha2,3(N)ST which modi

269 gene cluster contains three closely related sulfotransferases (Teg12, -13, and -14) that sulfate tei

270 CHST10 is a sulfotransferase that forms HNK-1 glycan on neural cell

271 ulfotransferase 4A1 (SULT4A1) is a cytosolic sulfotransferase that is highly conserved across species

272 work demonstrates that SSU-1 is a functional sulfotransferase that likely modifies endocrine signalin

273 ynthesis of HS includes numerous specialized sulfotransferases that generate a variety of sulfated sa

274 higher organization level of tyrosylprotein sulfotransferases that may serve for substrate selectivi

275 and DS in the Golgi apparatus is mediated by sulfotransferases that modify sugar chains through trans

276 7 Mb) that contained a pair of overexpressed sulfotransferases that were inversely correlated with ge

277 alized glycosyl transferases, epimerase, and sulfotransferases, this approach should mimic the synthe

278 are tyrosine sulfated by the tyrosylprotein sulfotransferase TPST/SGN2.

279 on by using recombinant human tyrosylprotein sulfotransferases TPST-1 and TPST-2 to modify a peptide

280 lfate (PAPS) synthase-coupled tyrosylprotein sulfotransferase (TPST) catalysis system that involves i

281 Tyrosyl protein sulfotransferase (TPST) is an enzyme required for produc

282 dification (PTM) catalyzed by tyrosylprotein sulfotransferases (TPST).

283 mediated by one of two Golgi tyrosylprotein sulfotransferases (TPST-1 and -2) expressed in all mamma

284 modification catalyzed by two tyrosylprotein sulfotransferases (TPST-1 and TPST-2) in the trans-Golgi

285 ion is mediated by two Golgi tyrosyl-protein sulfotransferases (TPST-1 and TPST-2) that are widely ex

286 mediated by one of two Golgi tyrosylprotein sulfotransferases (TPST1 and TPST2) that catalyze the tr

287 ed markedly by overexpression of the tyrosyl sulfotransferase TPST2.

288 Tyrosylprotein sulfotransferases (TPSTs) are enzymes that catalyze post

289 urylation is catalyzed by the tyrosylprotein sulfotransferases (TPSTs), and in humans there are two i

290 es mediated by purified human tyrosylprotein sulfotransferases (TPSTs), and unambiguously determined

291 ST followed by keratan sulfate galactose 6-O sulfotransferase treatment.

292 Recent evidence indicates that the same two sulfotransferases underlie the formation of functional P

293 A sulfotransferase was identified as the causative gene by

294 Remarkably these sulfotransferases were uniquely specific for sulfated su

295 1 (DS-epi1), together with the 6-O- and 4-O-sulfotransferases, were highly upregulated in ESCC biops

296 ggested that OH-PCB3s were the substrates of sulfotransferases which catalyzed the formation of PCB3

297 tion of ligand formation depends on the Pipe sulfotransferase, which is expressed in ventral cells of

298 dictated by sulfation patterns controlled by sulfotransferases, which add sulfate groups, and sulfata

299 is directly mediated by cytosolic and Golgi sulfotransferases, which use 3'-phosphoadenosine 5'-phos

300 that clearance of the nucleotide product of sulfotransferases within the Golgi plays an important ro