ライフサイエンスコーパス: superfamily

1 ing to the G protein-coupled receptor (GPCR) superfamily.

2 one of the largest families in the human SLC superfamily.

3 re members of the PLC-like phosphodiesterase superfamily.

4 structurally conserved within the ATP-grasp superfamily.

5 pentameric ligand-gated ion channel (pLGIC) superfamily.

6 kinase (CDPK) and Snf1-related kinase (SnRK) superfamily.

7 nding site in the G-protein-coupled receptor superfamily.

8 enase and a member of the NADH dehydrogenase superfamily.

9 ctivation by ligands of the nuclear receptor superfamily.

10 mprehensive classification of the ABC ATPase superfamily.

11 cogenic mutations were identified in the Ras superfamily.

12 miropin, a protease inhibitor in the serpin superfamily.

13 This residue is conserved in the GT-C superfamily.

14 y Rab5A, a small G protein of the Ras GTPase superfamily.

15 c leucine zipper transcription factor (bZIP) superfamily.

16 ltidrug transporter of the major facilitator superfamily.

17 eins that belong to the solute carrier (SLC) superfamily.

18 urotrophic factor family within the TGF-beta superfamily.

19 mbers of the transforming growth factor beta superfamily.

20 turn part of the larger alpha/beta-hydrolase superfamily.

21 d diversity of the enormously important P450 superfamily.

22 represents a new family within the bCcP/MauG superfamily.

23 of the large type IV secretion system (T4SS) superfamily.

24 e-activation phenotypes observed in the VGIC superfamily.

25 sic helix-loop-helix Per-Arnt-Sim (bHLH-PAS) superfamily.

26 genesis proteins that belong to WD40 protein superfamily.

27 ssociated regions near genes in the TGF-beta superfamily.

28 e proteins of the G-protein-coupled receptor superfamily.

29 atalytic promiscuity is widespread in the AP-superfamily.

30 might be widespread among this translocation superfamily.

31 2, and nearly half are members of the ADAMTS superfamily.

32 s of clades of the alkaline phosphatase (AP) superfamily.

33 ong to the G protein-coupled receptor (GPCR) superfamily.

34 mechanism for the Ca(2+)/cation transporter superfamily.

35 of the gonadotropin-releasing hormone (GnRH) superfamily.

36 ymes from the all-alpha NTP phosphohydrolase superfamily.

37 ansporter belonging to the Major Facilitator Superfamily.

38 smembrane glycoprotein in the immunoglobulin superfamily.

39 s in the genes encoding members of the 2OGDD superfamily.

40 enzymes belonging to the Nitro-FMN-reductase superfamily.

41 on factor and a member of a hormone receptor superfamily.

42 603 as a remote member of the protein kinase superfamily.

43 ing interest as therapeutic drugs in all the superfamily.

44 oglobulin, cadherin, and leucine-rich repeat superfamilies.

45 As a member of the superfamily 2 (SF2) helicases, NS3 requires the binding

46 ining protein 3 (PNPLA3) and transmembrane 6 superfamily 2 (TM6SF2).

47 DHX36 contains the superfamily 2 helicase core and several auxiliary domain

48 We describe the addition of new SUPERFAMILY 2.0 profile HMM library containing a total o

49 an essential protein with a conserved DEDDy superfamily 3'-5' exonuclease domain.

50 ial GCN5-related N-acetyltransferase (bGNAT) superfamily acetylate the epsilon amino group of an acti

51 understand how different members of the AAA+ superfamily achieve specialized biological functions.

52 telium discoideum, model of the evolutionary superfamily Amoebozoa.

53 ucible molecule 14 (Fn14), belong to the TNF superfamily and are involved in proinflammatory response

54 -isomer-specific 2-hydroxyacid dehydrogenase superfamily and displayed the highest similarity to the

55 otein functional constraints are manifest as superfamily and functional-subgroup conserved residues,

56 IL-38 is the most recent member of the IL-1 superfamily and has anti-inflammatory properties similar

57 al (CLC) protein is a member of the Galectin superfamily and is also known as galectin-10 (Gal-10).

58 on of redox regulation in the protein kinase superfamily and may open new avenues for targeting human

59 on of the prokaryotic aldehyde dehydrogenase superfamily and their diversity of function.

60 the entire two-barrel nucleotide polymerase superfamily, and a nucleotide selectivity (s) motif spec

61 transport, complement system, immunoglobulin superfamily, and hemostasis are increased in early plaqu

62 utative transporter of the major facilitator superfamily, and show that it is rapidly phosphorylated

63 The membership of the PIR superfamily, and whether the family includes Plasmodium

64 h genome size, but a diversity of around 200 superfamilies appeared to correlate with an abrupt switc

65 Twenty-six of the 33 superfamilies are disulfide-rich peptides, and we show t

66 Most members of the MttB superfamily are encoded by genes that lack the codon for

67 Members of this superfamily are key in triggering sexual maturation in v

68 to the resistance-nodulation-division (RND) superfamily are ubiquitous in Gram-negative bacteria.

69 Enzymes of the serine hydrolase superfamily are ubiquitous, highly versatile catalysts t

70 Using the NTF2-like structural superfamily as a model system, we developed an enumerati

71 a member of the haloacid dehalogenase (HAD) superfamily, as previously unrecognized modulators of fe

72 aracterized member of the scavenger receptor superfamily-as a receptor for VEEV.

73 Members of this superfamily assemble from five subunits, each of which c

74 the latest structural domain boundaries and superfamily assignments, and CATH+, which adds layers of

75 present a comprehensive analysis of the FAO superfamily based on reaction mechanism and substrate re

76 aptive immune system based on the MHC and Ig superfamily-based AgR.

77 y a dehalogenase of the alpha/beta hydrolase superfamily (BbdC).

78 udokinases are members of the protein kinase superfamily but signal primarily through noncatalytic me

79 he short-chain dehydrogenase/reductase (SDR) superfamily, but its potential role in Pel-dependent bio

80 thin the large HD-domain/PDEase-like protein superfamily, but no eukaryotic members of this subfamily

81 at the Activin/Nodal pathway of the TGF-beta superfamily, but not the BMP pathway, is the primary dor

82 ep toward understanding evolution of the TFF superfamily by determining a global phylogeny and using

83 CPD belongs to the 2H phosphotransferase superfamily by dint of its conserved central concave bet

84 orters from the ubiquitous Major Facilitator Superfamily can successfully insert into a synthetic bil

85 ber of the bacterial cytochrome c peroxidase superfamily, capable of generating a highly unusual Fe(I

86 e CD19 belongs to the extensively studied Ig superfamily, CD81 belongs to a poorly understood family

87 Two conserved IgCAMs (immunoglobulin superfamily cell adhesion molecules), neuroglian (Nrg) a

88 n-remodeling activities directed by SWI/SNF2 superfamily complexes play important roles in these proc

89 The TGF-beta superfamily comprises two distinct branches: the Activin

90 rase MttB is the first described member of a superfamily comprising thousands of microbial proteins.

91 The flavin-dependent amine oxidase (FAO) superfamily consists of over 9000 nonredundant sequences

92 n this study, we show that LarA is part of a superfamily containing many different enzymes.

93 that it belongs to the alkaline phosphatase superfamily, contains a Zn(2+) ion at its active center,

94 lammatory MoAPC are the key providers of TNF superfamily costimulatory signals, a signal we refer to

95 The C1q complement/TNF-related protein superfamily (CTRPs) displays differential effects on the

96 models induced by AT(1) -AA or LIGHT, a TNF superfamily cytokine (TNFSF14).

97 ort here that tumor necrosis factor receptor superfamily death receptor 3 (TNFRSF25, DR3) and Fas rec

98 hted the structural similarity of the kinase superfamily despite notable differences in primary amino

99 Domain superfamily diversity correlated with genome size, but a

100 BA receptors, while the other members of the superfamily do not have assigned ligands.

101 The database now includes Superfamily domain annotations for millions of protein s

102 Here we show that major facilitator superfamily domain containing 7C (MFSD7C) uncouples mito

103 ScoA3V, also featuring a PUA superfamily domain, but of a different clade, exhibited

104 , a transmembrane protein, and MGRN1, a RING superfamily E3 ligase, assemble to form a receptor-like

105 tems, Cas4-like activity is supplied by DnaQ-superfamily exonucleases, providing a beautiful example

106 tructure of DslA reveals a modified lysozyme superfamily fold, with several adaptations.

107 requirement for around 36 protein structural superfamilies for a viable NCLDV, and beyond around 200

108 one of the largest and most ancient protein superfamilies found in all living organisms.

109 divergent evolution of the adenylate-forming superfamily from a core enzyme scaffold most related to

110 ssects the genetic landscape of the TGF-beta superfamily genes in HCC and discusses the essential eff

111 r follistatin, an antagonist of the TGF-beta superfamily genes.

112 es for a viable NCLDV, and beyond around 200 superfamilies, genome expansion by the acquisition of ne

113 and ALG10-are glycosyltransferases of the C-superfamily (GT-Cs), which are loosely defined as contai

114 ol protein 42 homolog (Cdc42) protein, a Ras superfamily GTPase, regulates cellular activities, inclu

115 RAC2) is a member of the RHO subclass of RAS superfamily GTPases required for proper immune function.

116 genin (hANG), a member of the Ribonuclease A superfamily has angiogenic, neurotrophic and neuroprotec

117 hia coli, MurJ, a member of the MOP exporter superfamily, has been recently shown to have lipid II fl

118 ceptors in the ionotropic glutamate receptor superfamily have been targeted for the treatment of mood

119 Members of the arrestin superfamily have great propensity of self-association, b

120 ontains primary sequence homology to the GST superfamily; however, the question of whether GDAP1 is a

121 t stalled replication, serves as a model for Superfamily I helicases.

122 d proteins, most of which are immunoglobulin superfamily (IgSF) proteins, using a high-throughput, au

123 e its clinical relevance, the immunoglobulin superfamily (IgSF) remains uncharacterized and underrepr

124 ngs to gonadotropin-releasing hormone (GnRH) superfamily, implying an analogous role in growth and ma

125 plant, extend our knowledge of the anoctamin superfamily important for plants and fungi, and provide

126 the 56-member P. falciparum serine hydrolase superfamily in the asexual erythrocytic stage of P. falc

127 luciferase-like hydride transferase protein superfamily in the biosynthesis of bioactive molecules.

128 hylogenetic relationships of the SEC14L-PITP superfamily in the green lineage.

129 r analyses suggest an origin of this protein superfamily in the last common eukaryotic ancestor.

130 A2a and OXA2b are unique members of the Oxa1 superfamily, in that they possess a tetratricopeptide re

131 eactive Intermediate Deaminase (Rid) protein superfamily includes eight families among which the RidA

132 ell adhesion molecules of the immunoglobulin superfamily including neurofascin, encoded by the NFASC

133 The transforming growth factor-beta superfamily, including activins and growth differentiati

134 broader functionalities of members of the Ig superfamily, including cell surface-exposed receptors.

135 Perspective provides an overview of the SLC superfamily, including their biochemical and functional

136 structures including a sub-classification of superfamilies into functional families (FunFams).

137 ood network were constructed, organizing the superfamily into eight subgroups that accord with substr

138 Of these, the class A GPCR superfamily is highly represented, and continued drug di

139 nical member of the NRPS condensation domain superfamily is identified, named the interface domain, w

140 Signaling by the TGF-beta superfamily is important in the regulation of hematopoie

141 The GPCR superfamily is the largest in the human genome, and GPCR

142 mino acid, polyamine, and organocation (APC) superfamily is the second largest superfamily of membran

143 APETALA2/ethylene response factor (AP2/ERF) superfamily, is a transcription factor that regulates st

144 death receptor 3 (DR3), a member of the TNFR superfamily, is ex vivo expressed and predominantly upre

145 coli, FtsEX, a member of the ABC transporter superfamily, is involved in regulating the assembly and

146 selective channel in the metal ion transport superfamily, is the major Mg(2+)-influx pathway in proka

147 denosylmethionine (RaS) enzymes, a versatile superfamily known to catalyze some of the most unusual r

148 Genes encoding most members of the MttB superfamily lack the codon for pyrrolysine that distingu

149 n that binds transforming growth factor beta superfamily ligands to reduce SMAD2 and SMAD3 signaling,

150 ds to select transforming growth factor beta superfamily ligands, may enhance erythroid maturation an

151 iameter of model proteins, including the APC-superfamily lysine transporter Lyp1.

152 OPA1, a large GTPase of the dynamin superfamily, mediates fusion of the mitochondrial inner

153 a member of the Phase II detoxifying enzyme superfamily, mediates reduction of cisplatin ototoxicity

154 Thioesterase superfamily member 1 (Them1) is transcriptionally up-reg

155 esistant (Acp5), cathepsin K (Ctsk), and TNF superfamily member 11 (Tnfsf11) mRNA, receptor activator

156 ecreased the induction of mRNA levels of TNF superfamily member 11 (Tnfsf11, encoding the osteoclasto

157 TNF receptor superfamily member 14 (TNFRSF14, also called HVEM) and l

158 stigate the effects of tumor necrosis factor superfamily member 14 (TNFSF14, also called LIGHT) on fi

159 unostaining for tumor necrosis factor ligand superfamily member 14; sparse mast cell degranulation; n

160 Thioesterase superfamily member 2 (Them2) is an acyl-coenzyme A (CoA)

161 e rs58542926 polymorphism in transmembrane 6 superfamily member 2 (TM6SF2) is a genetic factor predis

162 n containing 3 (PNPLA3), and transmembrane 6 superfamily member 2 (TM6SF2) variants, and gut microbio

163 omal TG transfer protein and transmembrane 6 superfamily member 2 (TM6SF2), the latter being confirme

164 protein 3 [PNPLA3] p.I148M; transmembrane 6, superfamily member 2 [TM6SF2] p.E167K; and hydroxysteroi

165 omain containing 7), TM6SF2 (transmembrane 6 superfamily member 2), GCKR (glucokinase regulator), and

166 olipase domain containing 3, transmembrane 6 superfamily member 2, membrane-bound O-acyltransferase d

167 t transforming growth factor-beta (TGF-beta) superfamily member activin A is increased in the DH on a

168 Here, we identified the BAR domain superfamily member bridging integrator 2 (BIN2) as an in

169 mimic of the tumor necrosis factor receptor superfamily member HVEM (herpesvirus entry mediator), wh

170 The superfamily member MtcB is found in the human intestinal

171 The TNF receptor superfamily member OX40 (CD134) is a cell surface marker

172 Gdf15 encodes a TGF-beta superfamily member that is rapidly activated in response

173 Expression of TNF-receptor-superfamily-member 18 (TNFRSF18, glucocorticoid-induced

174 anscription elongation factor A-like (Tceal) superfamily members Bex1 and Tceal8.

175 ression of T-cell stimulating immunoglobulin superfamily members CD300LB, CD83, SIGLEC12, as well as

176 Poly(ADP-ribose) polymerase (PARP) superfamily members covalently link either a single ADP-

177 XPG DNA binding elements conserved with FEN1 superfamily members enable insights on DNA interactions.

178 Unlike other dynamin superfamily members including MFN1, MFN2 forms sustained

179 IL-36 cytokines are proinflammatory IL-1 superfamily members, yet their role in enteropathogenic

180 tudies have focused on comparing a subset of superfamily members.

181 the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms

182 icted interbacterial toxins of the deaminase superfamily, members of which have found application in

183 erized gene that encodes a major facilitator superfamily (MFS) transporter.

184 oding members of the DExD/H-box RNA helicase superfamily might also underlie developmental delay and/

185 transport by the bacterial major facilitator superfamily multidrug-proton antiporter LmrP in Lactococ

186 genic regions, with a preference for certain superfamilies of DNA transposable elements.

187 this question, we characterized the expansin superfamilies of the greater duckweed Spirodela, the mar

188 hal Australian funnel-web spider produces 33 superfamilies of venom peptides and proteins.

189 The cadherin superfamily of adhesion molecules carry O-linked mannose

190 s that the NPN cofactor is used by a diverse superfamily of alpha-hydroxyacid racemases and epimerase

191 Within the larger ABC superfamily of ATPases, ABCF family members eEF3 in Sacc

192 e structural maintenance of chromosome (SMC) superfamily of ATPases.

193 or (FXR) is a member of the nuclear receptor superfamily of bile acid-activated transcription factors

194 tance (MscS) constitute a remarkably diverse superfamily of channels critical for management of osmot

195 The histone deacetylases (HDACs) are a superfamily of chromatin-modifying enzymes that silence

196 BREX (for BacteRiophage EXclusion) is a superfamily of common bacterial and archaeal defence sys

197 In this review, we summarize the RND superfamily of efflux transporters with a primary focus

198 Members of the metallo-beta-lactamase (MBL) superfamily of enzymes harbor a highly conserved alphabe

199 All of these oncometabolites inhibit a superfamily of enzymes known as alpha-ketoglutarate-depe

200 The ATP-grasp superfamily of enzymes shares an atypical nucleotide-bin

201 tarate-dependent dioxygenases (2OGDDs) are a superfamily of enzymes that play diverse roles in many b

202 CT) is a eukaryotic enzyme that belongs to a superfamily of exoribonucleases, endonucleases, and phos

203 l assemblies of type IV pilins, constitute a superfamily of filamentous nanomachines virtually ubiqui

204 we show that Fsq is a member of the diverse superfamily of flavin- and deazaflavin-dependent oxidore

205 zed during vertebrate evolution, and the TNF superfamily of genes has been identified as essential fo

206 ember of the transforming growth factor beta superfamily of growth factors and negatively regulates s

207 The superfamily of hepatic cytochrome P450 (CYP) enzymes is

208 be a unifying characteristic of the emerging superfamily of HO-like diiron oxidases and oxygenases (H

209 Rhomboids, the most widespread and largest superfamily of intramembrane proteases, are known to pla

210 ithelial sodium channel/degenerin (ENaC/DEG) superfamily of ion channels and are expressed throughout

211 The transient receptor potential (TRP) superfamily of ion channels has garnered significant att

212 tion (APC) superfamily is the second largest superfamily of membrane proteins forming secondary trans

213 the founding member of a widely distributed superfamily of microbial proteins.

214 is achieved by peptidylprolyl isomerases, a superfamily of molecular chaperones.

215 ide natural products (RPNPs), form a growing superfamily of natural products that are produced by man

216 The active-site belongs to the 'PD-D/EXK' superfamily of nucleases and contains the motif SD-X11-E

217 yzed by a suite of enzymes that comprise the superfamily of oxidoreductases (Enzyme Classification EC

218 Immunophilins, a superfamily of peptidyl-prolyl cis-trans isomerase (PPIa

219 smembrane segments and belongs to the dCache superfamily of periplasmic sensor domains.

220 transferase mu-1 (GSTM1), which belongs to a superfamily of phase 2 antioxidant enzymes.

221 They are also part of a widespread superfamily of photoreceptors with diverse spectral and

222 Expansins comprise a superfamily of plant cell wall loosening proteins that c

223 proteostatic functions performed by the AAA+ superfamily of protein molecular machines.

224 of the Resistance-Nodulation-Division (RND) superfamily of proteins creating an efficient permeabili

225 ed with various cellular activities (AAA(+)) superfamily of proteins.

226 The Ras superfamily of small GTPases are guanine-nucleotide-depe

227 X receptors, members of the nuclear receptor superfamily of transcription factors, by type I interfer

228 effect of LTalpha, another member of the TNF superfamily, on HSV-1 latency and eye disease is not kno

229 Death Receptor 3 (DR3), a member of the TNF superfamily, on visceral adipose tissue (VAT)-derived mu

230 Members of the nuclear receptor (NR) superfamily orchestrate cellular processes that can impa

231 is perhaps the most enigmatic member of the superfamily, owing to its extra C-terminal domain of unk

232 signaling pathways, such as Wnt and Tgf-beta superfamily pathways, that are involved in their cell-fa

233 ubiquitous Nuclear Transport Factor-2 (NTF2) superfamily (pfam02136).

234 he resistance-nodulation-cell division (RND) superfamily play significant roles in mediating bacteria

235 EGFL6, a member of the EGF-like superfamily, plays an important role during embryonic de

236 Results reveal that the superfamily predates the divergence of Bacteria and Arch

237 Csx3 is a distant member of the CARF domain superfamily previously characterized as a Mn(2+)-depende

238 scriptomic approaches, we report that the Ig superfamily protein GPA33 is expressed on a subset of hu

239 antibiotic biosynthesis monooxygenase (ABM) superfamily protein leads to a significant increase both

240 tudy identified expression of a conserved Ig superfamily protein, Basigin, at the glial membrane of D

241 ing protein 1 (hGBP1) belongs to the dynamin superfamily proteins and represents a key player in the

242 ntly identified two groups of immunoglobulin superfamily proteins in Drosophila, Dprs and DIPs, as st

243 pe and identify a non-catalytic role for ABM superfamily proteins in type II polyketide synthase asse

244 neuroligins, protocadherins, immunoglobulin superfamily proteins, and leucine-rich repeat proteins,

245 structural maintenance of chromosomes (SMC) superfamily proteins.

246 cule downstream of the tumor necrosis factor superfamily receptors such as CD27, in the regulation of

247 xP crystal structures and those of other int-superfamily recombinases.

248 The GTPases of the Ras superfamily regulate cell growth, membrane traffic and t

249 During development, signaling by this superfamily regulates a variety of embryological process

250 4-1BBL, a member of the TNF superfamily, regulates the sustained production of infla

251 overexpression of BMP7, a member of the TGFB superfamily, represents a mechanism for resistance to an

252 Overall, analysis of the FAO superfamily reveals a modular fold with cofactor and sub

253 cids of the binuclear metallophosphoesterase superfamily serve as the enzymic metal ligands in MPE: A

254 8 and 9509), revealing significantly reduced superfamily sizes.

255 Inhibition of the PARP superfamily tankyrase enzymes suppresses Wnt/beta-cateni

256 meric ion channel from the Cys-loop receptor superfamily targeted for psychiatric indications and inf

257 verse phyla, consistent with other ParE/RelE superfamily TAs, but more unusually occurring as a multi

258 cuta trans-species sRNAs can be grouped into superfamilies that have variation in a three-nucleotide

259 f receptor 4 (CXCR4) is a member of the GPCR superfamily that binds the CXC motif chemokine ligand 12

260 rs of the Cellulose synthase-like (Csl) gene superfamily that encode known (HvCslF6 and HvCslH1) and

261 es of the radical S-adenosylmethionine (SAM) superfamily that harbor one or more auxiliary [4Fe-4S] c

262 long to the binuclear metallophosphoesterase superfamily that includes the well-studied DNA repair nu

263 related gene (GITR) is a member of the TNFR superfamily that is expressed on cells of the immune sys

264 (MAP4K4) is an "upstream" member of the MAPK superfamily that is implicated in human cardiac muscle c

265 T2SS is part of an ancient type IV filament superfamily that may have been present within the last u

266 sequences from the carbon-nitrogen hydrolase superfamily that represent possible green catalysts for

267 , which is a member of the cytokine receptor superfamily that signals via Janus kinase-2-signal trans

268 Da member of the drug/metabolite transporter superfamily that traverses the membrane of the acidic di

269 We demonstrate that members of the cadherin superfamily, the clustered gamma-Protocadherins (PCDHGs)

270 eptor in the transforming growth factor-beta superfamily, the development of high-throughput sequenci

271 roduce a function for a member of the serpin superfamily, the largest and most ubiquitous group of pr

272 ease is a paradigm for the major facilitator superfamily, the largest family of ion-coupled membrane

273 rafficking of tumor necrosis factor receptor superfamily (TNFRSF) is tightly regulated, disruption of

274 Tumor necrosis factor superfamily (TNFSF) members, including TRAIL (TNFSF10),

275 okines (LTB; CD40; and tumor necrosis factor superfamily [TNFSF] members TNFSF11 [RANKL], TNFSF13B [B

276 rases from the Primase-Polymerase (Prim-Pol) superfamily to maintain genome stability.

277 hydrolyzed by a member of the amidohydrolase superfamily to yield 2-carboxy-l-lyxonate.

278 tory member of the serine protease inhibitor superfamily-translocates from the cytosol to mitochondri

279 n and activity of ATP-binding cassette (ABC) superfamily transporters.

280 s of the human UDP-glycosyltransferase (UGT) superfamily typically catalyze the covalent addition of

281 e function(s) of most of the enzymes in this superfamily unknown.

282 Proteins in the alpha-macroglobulin (alphaM) superfamily use thiol esters to form covalent conjugatio

283 The glycyl radical enzyme (GRE) superfamily utilizes a glycyl radical cofactor to cataly

284 sister to vombatids, with which it forms the superfamily Vombatoidea as defined here.

285 tand the evolution of this PCAD-Memo protein superfamily, we explored their structural and functional

286 large, yet poorly characterized conotoxin H-superfamily, we used NMR and CD spectroscopy along with

287 derlies the functional diversity of the AAA+ superfamily were uncertain.

288 ret, species belonging to the two carnivoran superfamilies, which have had independent evolutionary t

289 ubclass of the ionotropic glutamate receptor superfamily, which functions as glutamate-gated cation c

290 member of the tumor necrosis factor receptor superfamily, which has been considered as a target for t

291 art of the microtubule-binding motor protein superfamily, which serves important roles in cell divisi

292 is a member of the voltage-gated ion channel superfamily, which stands out in design: It is a dimer o

293 SLAMF6 is a homotypic receptor of the Ig-superfamily whose exact role in immune modulation has re

294 long to the universally distributed ferritin superfamily, whose members function as iron detoxificati

295 gs to the functionally diverse HEPN nuclease superfamily, whose members rely on distinct cues for nuc

296 provide classification of almost all domain superfamilies with representatives in the PDB.

297 ilin)-based light sensors in the phytochrome superfamily with a broad spectral range from the near UV

298 ifies a discrete member of the P-type ATPase superfamily with a role in leaf-to-leaf electrical signa

299 he transforming growth factor beta (TGFbeta) superfamily with potential therapeutic applications due

300 ral matches covered 429 known protein domain superfamilies, with the most highly represented being an