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1 enotype is controlled by a single Mendelian 'supergene'.
2 pecies tree is estimated from the resultant 'supergenes'.
3  of disjunct clusters distributed across the supergene.
4 aeders) are controlled by an inversion-based supergene.
5 tion, retaining genetic diversity within the supergene.
6 ber variation in a separate subregion of the supergene.
7 loroplast genome, and the entire heterostyly supergene.
8 combination desert with characteristics of a supergene.
9 uals are recombinant between loci within the supergene.
10 e, function and evolution of this archetypal supergene.
11 egion of suppressed recombination, forming a supergene.
12 n, including inversions, translocations, and supergenes.
13 netic degeneration to drive the evolution of supergenes.
14 nario for the evolution of recombination and supergenes.
15  and establish co-adapted gene complexes, or supergenes.
16  that groups of tightly linked genes (i.e., "supergenes" [1, 2]) facilitate adaptation in suites of t
17                    We first identify the 'BC supergene', a broad region of suppressed recombination a
18  on these processes by investigating the 'BC supergene', a large genomic region comprising multiple r
19  dominance reversal across a large autosomal supergene, a mechanism for sexual conflict resolution ca
20 address the critical issue of what a mimicry supergene actually is at a functional level.
21 ccumulating changes that now distinguish the supergene allele from the standard allele.
22 monal components linked to presence of the b supergene allele in colony workers appear to be involved
23  predicted by allelic imbalance favoring the supergene allele.
24 and phylogenomic data to show that alternate supergene alleles are highly divergent at over 1,000 gen
25 ortance, little is known about how alternate supergene alleles arise and become differentiated, nor t
26      However, the evolution and functions of supergene alleles remain obscure because the identities
27          New research shows how alternative 'supergene' alleles of Estrogen Receptor 1 are differenti
28 election for reduced recombination between a supergene and a nearby locus providing additional benefi
29 aplotype, carrying a single allele of the BC supergene and dragging multiple non-synonymous mutations
30 identification of candidate genes within the supergene and for the mid-banding phenotype.
31  significant deficit of heterozygotes at the supergene and longer stretches of homozygosity in GoM po
32  provides a resource for fine mapping of the supergene and other major shell phenotype loci.
33 es considered separately or combined into a 'supergene') and the way gene-specific rate models are ap
34 ation, involves a putative colour patterning supergene, and co-occurs with infection by the male-kill
35 a set of RAD-seq-derived loci that flank the supergene, and instances of recombination tested by comp
36  a counterexample to classic inversion-based supergenes, and shed new light on the origin and mainten
37                  This finding highlights how supergene architecture can enable a complex adaptive phe
38 ctional role of multiple elements within the supergene architecture has been demonstrated, conclusive
39           We find that this X chromosome has supergene architecture, harboring extensive structural r
40 e shown that the Primula and Turnera distyly supergenes are both hemizygous in thrums, but it remains
41                                              Supergenes are clusters of linked genetic loci that join
42                                              Supergenes are clusters of physically linked, co-evolvin
43                                              Supergenes are clusters of tightly linked genes that joi
44                                Meiotic drive supergenes are complexes of alleles at linked loci that
45 is is in contrast to the long-held view that supergenes are likely to be controlled by a tightly link
46                                              Supergenes are multiple linked genes that regulate compl
47                                              Supergenes are widespread in nature.
48                   Here we reveal the S locus supergene as a tightly linked cluster of thrum-specific
49 support of the human leukocyte antigen (HLA) supergene as a tumor suppressor.
50 ncover 20-40 Ma of evolutionary history of a supergene associated with polymorphic social organizatio
51 but we discovered a ~ 31 megabase bi-allelic supergene associated with the size polymorphism, with th
52                                              Supergenes can evolve when recombination-suppressing mec
53                  These results highlight how supergenes can readily move across species boundaries, p
54                                              Supergene chalcocite enrichment during weathering is an
55                                    Autosomal supergenes, chromosomal regions containing tightly linke
56                             Shuker introduce supergenes - clusters of genes that control complex trai
57                                              Supergenes, clusters of tightly linked genes, play a key
58               Maser maps in a closely linked supergene complex that controls multiple armor, feeding,
59 bility is controlled by a highly polymorphic supergene complex, the S-locus, which is structurally co
60 ity of the evolutionary development of large supergene complexes that confer a selective advantage to
61 f the evolution of sex chromosomes and other supergene complexes.
62                         The major locus is a supergene comprising four genes.
63  Despite recent criticism, we argue that the supergene concept remains relevant and is more testable
64 to satellites and faeders is determined by a supergene consisting of divergent alternative, dominant
65 ween the morphs is controlled by an S-locus "supergene" consisting of several distinct genes that det
66 e or more loci, of which five make a single 'supergene' containing tightly linked colour and banding
67 eveals that the most conserved region of the supergene contains a transcription factor essential for
68 ysically linked and inherited together as a 'supergene', control the shell colour and banding polymor
69 c innovations involved in the formation of a supergene controlling a complex social phenotype.
70 ll shape, suggesting the inversion acts as a supergene controlling multiple linked traits.
71                The locus is an example of a 'supergene' controlling multiple complex phenotypes.
72                                The doublesex supergene controls mimicry polymorphism in the swallowta
73 victa and closely related species, a "social supergene controls whether a colony maintains one or mul
74 g Batesian mimicry, a multi-gene complex or 'supergene' controls the multiple differences between mim
75 ern of divergence indicates that the Formica supergene does not follow standard models of sex chromos
76 al gradient in ecotype distribution suggests supergene driven variation in color and bill morphology
77 ee inversions constituting the Social b (Sb) supergene emerged sequentially during the separation of
78 activity may thus be a fundamental factor in supergene enrichment of copper deposits.
79   As hemizygosity has major consequences for supergene evolution and loss, clarifying whether this ge
80 s around the world and have implications for supergene evolution broadly.
81 uggests that rare recombination events shape supergene evolution in surprising ways.
82 otypes, our empirical understanding of early supergene evolution is limited.
83 esults therefore support classic theories of supergene evolution, but update those ideas to match wha
84 nger supergene, providing novel insight into supergene evolution.
85 ay reflect the functional diversification of supergene families consistent with major differences in
86 veals that a considerable expansion of these supergene families has occurred in the mosquito.
87       This process is facilitated by several supergene families that catalyze oxidative metabolism as
88 coproteins are members of the immunoglobulin supergene family and are related structurally to carcino
89 ithelial adhesion molecule of immunoglobulin supergene family and has been implicated in the growth s
90 uzi CRP and its relationship to the T. cruzi supergene family comprising active trans-sialidase (TS)
91 mbers of the glutathione S-transferase (GST) supergene family is associated with altered NMSC risk in
92  that the function of many members of the Ig-supergene family is dependent on interactions with cytop
93            The protein tyrosine kinase (PTK) supergene family is the key mediator in cellular signali
94  of the desmoglein subfamily of the cadherin supergene family of cell adhesion molecules.
95                    Apobec-1 is a member of a supergene family of cytidine deaminases, with several ho
96 ma and PPARalpha, comprise a subclass of the supergene family of nuclear receptors.
97 ells express one or more members of the Ly-6 supergene family of small glycosylphosphatidylinositol-l
98 osophila mef2 gene, a member of the MADS box supergene family of transcription factors, is critical f
99 cytochromes P450, the dominant froms of this supergene family that catalyze the oxidation of numerous
100                 CD200R is a member of the Ig supergene family that is primarily expressed on myeloid
101 member of the carcinoembryonic antigen (CEA) supergene family, indicate that it is a multifunctional
102 in (or spectrin II), members of the spectrin supergene family.
103 146, is a novel member of the immunoglobulin supergene family.
104 protein belonging to the carcinoembryonic Ag supergene family.
105 ly assembled in the S. richteri lineage, the supergene first introgressed into S. invicta, and from t
106 f recombination tested by comparing inferred supergene genotype against RAD-marker genotype.
107                                              Supergenes govern multi-trait-balanced polymorphisms in
108 organization is under the control of a novel supergene haplotype (termed Sb), which evolved by sequen
109                       Here, we show that the supergene haplotype associated with multiple-queen colon
110  (SNPs) consistently distinguish alternative supergene haplotypes across all five species.
111 y under environmental selection, maintaining supergene haplotypes as a balanced polymorphism.
112 mica ant species, wherein we identified four supergene haplotypes on chromosome 3 underlying colony s
113 ings paint a picture of dynamic evolution of supergene haplotypes, fuelled by incomplete recombinatio
114 very small portion of this large and ancient supergene harbors conserved trans-species SNPs linked to
115                                          The supergene has captured ESR1, the gene that encodes estro
116    Recently, the molecular basis for several supergenes has been resolved.
117                                     Although supergenes have been identified in many species, we lack
118 ses during the early evolutionary stages of 'supergenes.' Here, we generated, synthesized, and analyz
119 ic architecture and evolution of the distyly supergene in Linum by generating a chromosome-level geno
120                    A new study of an ancient supergene in several ant species suggests that rare reco
121 ee inversions, with the single origin of the supergene in their common ancestor inferred by phylogeno
122  ratio is determined, at least in part, by a supergene in two species opens future research on the ev
123  investigating the evolutionary history of a supergene in white-throated sparrows, Zonotrichia albico
124  to lead to the discovery of many additional supergenes in a broad range of organisms and reveal simi
125 influence the phenotypic effects of presumed supergenes in hybrids.
126  been made, suggesting an important role for supergenes in the evolution of divergent behavioral phen
127 ilizing selection maintains three extensive "supergenes" in Atlantic cod, linking these genes to spec
128  within a number of putative differentiated "supergenes" in the rice genome, which may reflect crypti
129  but application at molecular levels (e.g., 'supergenes' in genetics) is more recent, with a consensu
130 ctional selection, whereas the single-locus (supergene) inheritance controlling polymorphism in H. nu
131                             Strikingly, this supergene is adjacent to another supergene spanning 5 Mb
132      Furthermore, molecular evolution of the supergene is dominated not by adaptive protein evolution
133                The functional basis for this supergene is manifold, enriched with genes that influenc
134 hen show that haplotype diversity within the supergene is surprisingly extensive: there are at least
135  the excess of heterozygote genotypes at the supergene locus controlling wing-pattern variation in na
136 herefore, shows that the architecture of the supergene may not be as previously supposed.
137 gation of adaptive variation within species, supergenes may facilitate the spread of complex phenotyp
138                                         Some supergenes may span entire chromosomes, because selectio
139 butterflies from a recent radiation in which supergene mimicry has been isolated to the gene doublese
140 show that a single gene, doublesex, controls supergene mimicry in Papilio polytes.
141                                              Supergene mimicry is a striking phenomenon but we know l
142 rk has explored the evolutionary dynamics of supergene mimicry, there are almost no empirical data th
143 cing an ore assemblage previously unknown in supergene mineralizing environments.
144 lanced polymorphisms are often controlled by supergenes: multiple tightly linked loci that function t
145          Here we focus on the young 'social' supergene of fire ants, a powerful system for disentangl
146 sically linked to sex determining loci as a 'supergene' on the sex chromosome.
147 lting from recent sub-surface replacement of supergene oxyhydroxides by carbonate and sulphide minera
148 d evolution of independently derived distyly supergenes, provide a counterexample to classic inversio
149 lutionary consequences of a size-determining supergene providing new insights for the management of v
150 lleles at a balanced >100-Mb inversion-based supergene, providing a unique system for studying gene-b
151 derlying queen winglessness within a younger supergene, providing novel insight into supergene evolut
152      Here, we study the evolution of a large supergene region that determines a major social and ecol
153                                              Supergene regions maintain alleles of multiple genes in
154            This barrier might be overcome in supergene regions, where suppressed recombination leads
155 agonism shaped the evolution of the fire ant supergene, resulting in distinct patterns of gene expres
156                                  Despite the supergene's size, only 142 single nucleotide polymorphis
157                                       These 'supergenes' segregate as stable polymorphisms within or
158 rom different hypotheses for the identity of supergenes, showing that a single gene can switch the en
159                                         This supergene shows strong genetic differentiation between p
160               This killer hidden in a social supergene shows that large nonrecombining genomic region
161 ingly, this supergene is adjacent to another supergene spanning 5 Mbp that is associated with variati
162                                We identify a supergene spanning 5.5 Mbp that is closely associated wi
163 for the chromosomal region that contains the supergene, specifically the colour locus (C), and the un
164 he traditional theory is that the underlying supergene that determines colour has evolved to prevent
165 he origin and possible fate of a fascinating supergene that determines the coloration and mating beha
166 irst phylogeny inferred from the heterostyly supergene that includes all species of Primula sect.
167 ve lost one of the two alleles of a putative supergene that is heterozygous in WTs.
168 s) and characterize a 55-Mb double-inversion supergene that mediates sex-specific migratory tendency
169 eries of chromosomal inversions has formed a supergene that segregates with an aggressive phenotype.
170 divergence and elucidated the composition of supergenes that control complex multi-trait polymorphism
171 ple of a balanced polymorphism governed by a supergene, the distyly S-locus.
172 the importance of large-effect mutations and supergenes, the role of development in shaping genetic v
173                                      The dsx supergene thus contains multiple functional genetic elem
174                                              Supergenes underlie striking polymorphisms in nature, ye
175             We discovered a novel rearranged supergene variant (9r) on chromosome 9 underlying queen
176 social forms) attributed to IGEs of a social-supergene variant (b allele).
177 365 haploid fire ant males, we show that the supergene variant responsible for multiple-queen colonie
178 s by identifying allelic differences between supergene variants, characterizing allelic expression ac
179 jor role in the evolution and maintenance of supergene variants.
180 ces of recombination between loci within the supergene were not easily verified.
181 such polymorphisms led to the concept of the supergene, where alternative phenotypes in a balanced po
182 rangement behave like Mendelian alleles of a supergene, which affect a suite of complex fitness-relat
183                        Chromosomal inversion supergenes, which form blocks of linked genes, are incre
184  yellow, within an inverted subregion of the supergene, while forewing tip pattern is most likely ass
185  evolved to be controlled by non-recombining supergenes, whose origins remain enigmatic.
186 etailed insight into the assembly of a plant supergene yet and have important implications for the ev

 
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