ライフサイエンスコーパス: superoxide radical

1 trochemical system against in-situ generated superoxide radical.

2 sfer and can reduce molecular oxygen forming superoxide radical.

3 al aconitase, suggesting they react with the superoxide radical.

4 bly through metabolic pathways involving the superoxide radical.

5 t antioxidant capacity, particularly against superoxide radical.

6 lecular O(2), facilitating the generation of superoxide radical.

7 D1 and chloroplastic CSD2) that can detoxify superoxide radicals.

8 generation, NOS is also capable of producing superoxide radicals.

9 zing the formation of hydrogen peroxide from superoxide radicals.

10 ling the NADPH oxidase complex and producing superoxide radicals.

11 sed sensitivity to intracellularly generated superoxide radicals.

12 lls in blood vessels to produce an excess of superoxide radicals.

13 ction via photosynthesis and the disposal of superoxide radicals.

14 clinical therapies for diseases mediated by superoxide radicals.

15 ucigenin-derived chemiluminescence evoked by superoxide radicals.

16 the tyrosine kinase-dependent generation of superoxide radicals.

17 complex III, seems to be a primary source of superoxide radicals.

18 hin a few minutes at neutral pH and produces superoxide radicals.

19 y correlated with the level of intracellular superoxide radicals.

20 ys against 2,2-diphenyl-1-picrylhydrazyl and superoxide radicals.

21 sion-controlled reaction of nitric oxide and superoxide radicals.

22 tance to H(2)O(2) have the highest levels of superoxide radicals.

23 apacity of infusions and beverages, based on superoxide radicals.

24 ing the scavenging of DPPH, nitric oxide and superoxide radicals.

25 d to be the scavenging and detoxification of superoxide radicals.

26 omotetramer of the 1Fe-SOR class, can reduce superoxide radicals.

27 ctivities as well as increased production of superoxide radicals.

28 gen deprivation, a donor of nitric oxide and superoxide radicals (3-morpholinosydnonimine), an inhibi

29 Superoxide radical adducts were observed in both WT and

30 In this way, two toxic species, superoxide radical and hydrogen peroxide, are converted

31 producer of reactive oxygen species such as superoxide radical and hydrogen peroxide, which may cont

32 When MnSOD is deficient, superoxide radical and its resulting reactive oxygen spe

33 eroxynitrite, the product of the reaction of superoxide radical and nitric oxide, and the integrity o

34 bination with PUT-CAT may eliminate both the superoxide radical and the H2O2 produced from the dismut

35 ns is exposed to a range of stresses such as superoxide radicals and cationic fluxes.

36 ies, this results primarily in production of superoxide radicals and does not require the Fenton reac

37 ocytosis of GBS was unaltered, production of superoxide radicals and hydrogen peroxide was markedly d

38 g reactions with molecular oxygen, producing superoxide radicals and hydrogen peroxide.

39 LIT1-null promastigotes accumulated superoxide radicals and initiated amastigote differentia

40 mitochondrial antioxidant enzyme, scavenges superoxide radicals and its overexpression provides neur

41 Hydroethidine was used to identify superoxide radicals and lipid peroxidation was visualize

42 SOR protein is a key enzymatic scavenger of superoxide radicals and protects the bacterium from oxid

43 ilar fashion, epithelial cells produced more superoxide radicals and were more susceptible to cytotox

44 oles for STAR-derived peroxysulfate radical, superoxide radical, and sulfo-NAD(P) in the mechanism of

45 the channel for electrostatic recognition of superoxide radical, and the connectivity of the intrasub

46 prevent reduction of cytochrome C(FeIII) by superoxide radical, and they reverse an age-dependent de

47 reactive oxygen species (ROS), specifically superoxide radicals, and induced apoptosis through the m

48 ases (SODs) are metalloenzymes that detoxify superoxide radicals, and occur in cytosolic (Cu,Zn-SOD)

49 Sanguinarine-induced production of superoxide radicals, and the addition of MnTBAP, a scave

50 of ~30 for (*)OH and by a factor of 2-10 for superoxide radicals, and we observed the emergence of or

51 he detection of the intra- and extracellular superoxide radical anion ([Formula: see text]).

52 nown agent of oxidative stress and source of superoxide radical anion (and indirectly, a causative of

53 d oxidation reaction mechanisms initiated by superoxide radical anion (O(2)()) and nitric oxide ((*)N

54 NO/O(2) (via nitrogen dioxide, (*)NO(2)) and superoxide radical anion (O(2)(*)(-)) promote Ras guanin

55 Reactive oxygen species (ROS), including the superoxide radical anion (O(2)(*-)), hydrogen peroxide (

56 enge three specific reactive oxygen species (superoxide radical anion (O(2)(-)), hydroxyl radical (HO

57 n be reoxidized by O2to Fe(III)-CBS, forming superoxide radical anion (O2 ()).

58 ing CDNMPO shows distinctive EPR spectra for superoxide radical anion (O2(*-)) compared to other biol

59 in trap that incorporates high reactivity to superoxide radical anion (O2(*-)), more persistent super

60 radical ((*)OH), singlet oxygen ((1)O2) and superoxide radical anion (O2(*-)).

61 reactivity of functionalized spin traps with superoxide radical anion (O2*-).

62 Scavengers of superoxide radical anion (superoxide dismutase), hydroge

63 s with HPLC-based simultaneous monitoring of superoxide radical anion and hydrogen peroxide provides

64 gulate platelet CD36 signaling by increasing superoxide radical anion and hydrogen peroxide through a

65 assays for monitoring cellular production of superoxide radical anion and hydrogen peroxide using hyd

66 omposition of SIN-1, a thermal source of the superoxide radical anion and nitric oxide.

67 ferentiate and quantify, for the first time, superoxide radical anion and singlet oxygen generated by

68 The results reveal that relative amounts of superoxide radical anion and singlet oxygen generated by

69 to differentiate two important types of ROS, superoxide radical anion and singlet oxygen, and to quan

70 cating involvement of enhanced generation of superoxide radical anion as an upstream signal.

71 gen species suggest a nucleophilic attack of superoxide radical anion followed by TNT denitration thr

72 lective NO synthase inhibitor), and Tiron (a superoxide radical anion scavenger) on the development o

73 ion of membrane lipids against oxidation and superoxide radical anion scavenging activity.

74 ctions with water, molecular oxygen, and the superoxide radical anion support the experimental findin

75 of balls, which promoted the generation of a superoxide radical anion via a SET process.

76 ar oxygen, leading to Ce (IV) and O(2) (*-) (superoxide radical anion) in approximately 1.0 ps, as co

77 athway requiring Src kinases, NADPH oxidase, superoxide radical anion, and hydrogen peroxide.

78 mediated photogeneration of singlet oxygen, superoxide radical anion, and photo-oxidation of added l

79 which is produced by the reaction of NO with superoxide radical anion.

80 rom the droplets using mass spectrometry and superoxide radical anions (*O(2)(-)) and hydroxyl radica

81 udies prove that the reaction progresses via superoxide radical anions (.O2(-)).

82 Oxidation is initiated by superoxide radical anions (O(2)(-)) that originate from

83 NAD(P)H/O2 system revealed the generation of superoxide radical anions (O2 *-).

84 ar oxygen leading to increased production of superoxide radical anions and oxidase-like activity.

85 secretory product from Necator americanus on superoxide radical anions generated by xanthine/xanthine

86 shown to depend markedly on the presence of superoxide radical anions.

87 High levels of the superoxide radical are still toxic.

88 vant to several neurological disorders where superoxide radicals are generated in the vicinity of gli

89 Reactive oxygen species (ROS) such as superoxide radicals are responsible for the pathogenesis

90 superoxide dismutase-deficient astrocytes to superoxide radicals artificially produced by paraquat tr

91 g hydrogen peroxide as the major product and superoxide radical as a minor product.

92 pe, surB1, and delta(cydAB) strains produced superoxide radicals at the same rate in vitro.

93 d in detail for their capability to generate superoxide radicals both in isolated enzymatic one- and

94 OD), the mitochondrial enzyme that catalyzes superoxide radical breakdown, in brain mitochondria from

95 The trapping of the superoxide radical by cytochrome c in the reaction of BH

96 The superoxide radical can scavenge endothelium-derived rela

97 , in addition to being a potential source of superoxide radical, CBS constitutes a previously unrecog

98 posing, concentration-dependent roles of the superoxide radical comprise a form of hormesis and show

99 n signaling and PLETHORA gradient as well as superoxide radical content, resulting in reduction of ce

100 n of 6-OHDA by COX-2 triggered production of superoxide radicals critical for both propagation of 6-O

101 ine interacts and oxidizes the iron to evoke superoxide radicals directly.

102 hypothesis, we first used in situ imaging of superoxide radical distribution by hydroethidine oxidati

103 l-2-picrylhydrazyl radical, nitric oxide and superoxide radicals (DPPH, NO and O(2)(-), respectively)

104 , and the addition of MnTBAP, a scavenger of superoxide radicals, efficiently inhibited sanguinarine-

105 spectrum produced implies that, besides the superoxide radical expected to be formed during autoxida

106 ical that efficiently reduces oxygen to form superoxide radicals for catalytic oxidative coupling rea

107 The amount of superoxide radicals formed during oxidation was investig

108 temporal release and dose of the therapeutic superoxide radicals from QDs.

109 e (from inducible nitric oxide synthase) and superoxide radicals (from NADPH oxidases and other sourc

110 he primary cellular defense against damaging superoxide radicals generated by aerobic metabolism and

111 Consistently, superoxide radicals generated by hypoxanthine and xanthi

112 IV deficiency and elevated nitric oxide and superoxide radical generation precede neuronal death in

113 function was associated with a reduction in superoxide radical generation, vascular cell adhesion mo

114 s cells sensitive to H(2)O(2) but not to the superoxide radical generator menadione.

115 cells and dopaminergic neurons by modifying superoxide radical handling in these selectively vulnera

116 The superoxide radical has not previously been directly dete

117 rite, a reaction product of nitric oxide and superoxide radicals, has been implicated in N-methyl-D-a

118 reases in levels of mitochondrially produced superoxide radicals have a protective effect during H(2)

119 uction of reactive oxygen species, including superoxide radical, hydrogen peroxide, and hypochlorous

120 active oxygen species (ROS; peroxyl radical, superoxide radical, hypochlorous acid), cytotoxicity ass

121 assays performed, a remarkable inhibition of superoxide radicals i.e. 94.25% observed with extracts o

122 he class of metalloenzymes that detoxify the superoxide radical in aerobic organisms.

123 s, a single MnSOD caters to the reduction of superoxide radical in both cytosol and thylakoid lumen/p

124 ismutases (SODs) catalyze the dismutation of superoxide radicals in a broad range of organisms, inclu

125 Manganese superoxide dismutase removes superoxide radicals in mitochondria, and thus protects m

126 ced the NADPH oxidase-mediated production of superoxide radicals in neurons that was involved in the

127 induce NADPH oxidase-mediated production of superoxide radicals in neurons, which was involved in th

128 ntravenous injection of hydroethidine due to superoxide radicals in photoreceptors, greater photorece

129 Involvement of superoxide radicals in selenomethionine toxicity in vivo

130 sults provide further evidence for a role of superoxide radicals in the long-term effects of METH.

131 2-MPTP-induced toxicity, thereby implicating superoxide radicals in the mechanism of action of a neur

132 ty and generated reactive oxygen species and superoxide radicals in vitro.

133 we show that H/R enhances the generation of superoxide radicals in wt CA (25.8 +/- 0.7 relative ligh

134 d from the reaction between nitric oxide and superoxide radicals, in impairing endothelial AKAP150-TR

135 eural debris and prevented the production of superoxide radicals induced by challenge with neural deb

136 MPO-OOH adduct converts the very short-lived superoxide radical into a more stable spin adduct.

137 The SODs convert superoxide radical into hydrogen peroxide and molecular

138 iron-oxygen bond resulting in the release of superoxide radical into the heme pocket.

139 e dismutase (SOD) is an enzyme that converts superoxide radicals into hydrogen peroxide and molecular

140 agnetic resonance spectroscopy, we show that superoxide radical ions (O2-) form directly on Mars-anal

141 turally dissolved oxygen (approx. 2 mM), the superoxide radical is co-electrogenerated during analyte

142 latter observation strongly supports that a superoxide radical is involved in the maturation mechani

143 anine lesions via combination of guanine and superoxide radicals is greatly reduced in the presence o

144 SOD), which catalyzes the dismutation of the superoxide radical, is present in the cytosol and mitoch

145 (2)-sensitive mutant strains have the lowest superoxide radical levels, and strains with the highest

146 l reactions between a versatile molecule and superoxide radical/Li(2)O(2).

147 s of the primary defense of the cell against superoxide radicals, manganese superoxide dismutase.

148 A mechanism of superoxide radical-mediated dimerization of EGCG and H2O

149 During T. cruzi invasion to macrophages, superoxide radical (O(2) (*-)) is produced at the phagos

150 Quantitation of superoxide radical (O(2)(*)(-)) production at the site o

151 , whereas increasing levels of extracellular superoxide radical (O(2)(*-)) using xanthine/xanthine ox

152 t enzymes responsible for the elimination of superoxide radical (O(2)(-)).

153 pecies, including hydroxyl radicals (HO(*)), superoxide radicals (O(2)(* -)), singlet oxygen ((1)O(2)

154 Cellular superoxide radicals (O(2)(-)) are mostly generated durin

155 fense against oxidative damage by converting superoxide radicals (O(2)(-)) to O(2) and H(2)O(2).

156 iplasm to offer protection from host-derived superoxide radicals (O(2)(-)).

157 rradiation with 730 nm light, LuCXB produces superoxide radicals (O(2)(-*)) via a type I photodynamic

158 iving tissues under inflammatory conditions, superoxide radicals (O(2)*)) are generated and are known

159 cCer stimulated the endogenous generation of superoxide radicals (O-2) about 5-fold compared with the

160 res in DOM, can reduce dioxygen molecules to superoxide radicals ((*)O(2)(-)) through a one-electron

161 Rate constants of superoxide radical (O2(*-)) reactions with nitrones were

162 s (SOD) are essential enzymes that eliminate superoxide radical (O2-) and thus protect cells from dam

163 roxynitrite is formed by the reaction of the superoxide radical (O2.-) with the nitric oxide radical

164 Superoxide radicals (O2( *-)) and their protonated form

165 (NO) in combination with singlet oxygen and superoxide radicals (O2(*-)) as reactive oxygen species

166 When C60 and HA were present as a mixture, superoxide radicals (O2(*-)) were 2.2-2.6 times more tha

167 known, mainly in non-neuronal systems, that superoxide radicals (O2-) activate these (and other) kin

168 ombination reaction between the 8-oxoGua and superoxide radicals occurs with the rate constant of (1.

169 The deleterious effect of superoxide radicals on cell growth and survival is predo

170 he conclusion that this new radical is not a superoxide radical or a mixture of superoxide and biopte

171 ing cells from oxidative damage arising from superoxide radical or reactive oxygen species produced f

172 they are sensitive to degradation induced by superoxide radicals or increased temperatures.

173 we challenge this view by examining the FAD-superoxide radical pair within cryptochrome, a protein h

174 According to this model, a flavin-superoxide radical pair, born in the singlet spin config

175 These results suggest that superoxide radicals play a role in the delayed ischemic

176 otocin, 3-morpholinosydnonimine (SIN-1), and superoxide radical produced by xanthine/xanthine oxidase

177 entify xanthine oxidase as a major source of superoxide radical production causing these toxic effect

178 to H(2)O(2), the wild-type strain increases superoxide radical production to activate this defense m

179 orting the notion that doxorubicin increases superoxide radical production.

180 reatment, yeast cells significantly increase superoxide radical production.

181 aintain iron in soluble form, EDDS acts as a superoxide radical-promoting agent, enhancing the genera

182 n peroxide, but not those that eliminate the superoxide radical, recapitulates the phenotype, thereby

183 tem for reliable and continuous detection of superoxide radical release from cell culture was develop

184 generated higher levels of nitric oxide and superoxide radicals, resulting in increased local peroxy

185 Addition of the superoxide radical scavenger tempol restored the ability

186 Hydroxyl and superoxide radical scavengers had no effect on the rate.

187 Thus, we propose that superoxide radical scavenging activity is a useful metho

188 enced by DPPH, a beta-carotene bleaching and superoxide radical scavenging activity-non-enzymatic ass

189 f the trypsin hydrolysate showed the highest superoxide radical scavenging activity.

190 c acid), 2,2-diphenyl-1-picryl-hydrazyl, and superoxide radical scavenging assays with IC(50) of 53.3

191 these heat products were studied by ABTS and superoxide radical scavenging assays.

192 vamide and these extracts by measuring their superoxide radical scavenging capabilities in a Rotating

193 Superoxide radical scavenging, lipid peroxidation inhibi

194 Superoxide radicals seem to participate in AMPH-induced

195 ssues of parasitic reactions associated with superoxide radicals, singlet oxygen, high overpotentials

196 tion of reduced oxygen intermediates such as superoxide radicals, singlet oxygen, hydrogen peroxide,

197 respiration generates a proton gradient and superoxide radicals, suggesting a possible link between

198 o be correlated with their ability to quench superoxide radicals suggests that the regulation of phas

199 in the absence of MnTBAP either formation of superoxide radicals suppressed NO production or part of

200 ations GD3 recruits nitric oxide to scavenge superoxide radicals that triggered signaling events that

201 cellular microenvironment (formation of the superoxide radical), the chemistry of NO will turn into

202 te that, under identical ratios of enzyme to superoxide radical, the dismutation efficiencies scaled

203 it simultaneously triggers the production of superoxide radicals, thereby causing toxicity in the Del

204 agosomes, they generate large amounts of the superoxide radical through the reduction of molecular ox

205 g) caused conversion of approximately 70% of superoxide radical to a novel radical, explaining how l-

206 Nitric oxide reacts with superoxide radical to form peroxynitrite, which generate

207 ial primary antioxidant enzyme that converts superoxide radical to hydrogen peroxide and molecular ox

208 ial primary antioxidant enzyme that converts superoxide radical to hydrogen peroxide and molecular ox

209 D1 ), which catalyses the dismutation of the superoxide radical to hydrogen peroxide and oxygen.

210 dismutase (SOD) catalyzes the conversion of superoxide radical to hydrogen peroxide.

211 of approximately 15 s(-1), the time for the superoxide radical to leave the heme pocket and reach th

212 ble for catalyzing the disproportionation of superoxide radical to oxygen and hydrogen peroxide.

213 e activity that converts O(2) into cytotoxic superoxide radicals to efficiently kill tumor cells.

214 superoxide dismutase catalyzes conversion of superoxide radicals to H(2)O(2), with catalase neutraliz

215 g enzymes that can catalyze the reduction of superoxide radicals to hydrogen peroxide and are importa

216 dismutases (SODs) catalyze the conversion of superoxide radicals to hydrogen peroxide and oxygen.

217 reactive oxygen species (ROS), specifically superoxide radicals, to induce apoptosis through both mi

218 The thermodynamic quantities for superoxide radical trapping by various nitrones have bee

219 t react with molecular oxygen and produce no superoxide radical under the typical settings of inhibit

220 cer cells prior to PS-mediated generation of superoxide radicals under near-infrared (NIR) illuminati

221 haride (glycan) of N. commune DRH1 generated superoxide radicals upon exposure to UV-A or -B irradiat

222 BH(4)-free eNOS(ox) produced the superoxide radical very efficiently in the absence of L-

223 In vivo oxidation of dihydroethidium by superoxide radical was also significantly lower in brain

224 Scavenging of superoxide radical was generally weak, except for the <1

225 The most potent peptide towards superoxide radicals was the four-amino-acid chain with a

226 lhydrazyl (DPPH), hydroxyl, nitric oxide and superoxide radicals were evaluated.

227 The superoxide radicals were spin-trapped via reaction with

228 nfection in part by issuing a burst of toxic superoxide radicals when challenged.

229 reactions with PFOA showed that hydroxyl and superoxide radicals, which are typically the primary pla

230 venging activity towards ABTS, hydroxyl, and superoxide radicals, which might explain their excellent

231 As MnSOD has been shown to remove superoxide radical with varying efficiency depending upo

232 ls on blood vessels to produce and excess of superoxide radicals, with attendant alterations in endot

233 vity resulted in significant accumulation of superoxide radicals (WT, 4.54 mumol/mg tissue/min; CatA-