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3 ular insights garnered over the past decade, supplanting a clinical classification that has served we
4 of restoring sensation, enabling movement or supplanting abnormal activity patterns in pathological b
5 Imatinib mesylate (IM, Gleevec) has largely supplanted allogeneic hematopoietic cell transplantation
6 n addition, limb-sparing surgery has largely supplanted amputation, though the effect of this change
7 her scavenging of isoLGs could complement or supplant antioxidant therapy, we exposed mice to bright
8 sform the scientific enterprise, potentially supplanting array-based technologies and opening up many
9 t, although other cellular sources of LT may supplant B lymphocytes in the formation of immature ILFs
11 enin-angiotensin-aldosterone system, perhaps supplanting beta blockers as first-line agents to regres
12 cribing patterns could explain why CCBs have supplanted better-substantiated therapies for hypertensi
14 eripheral blood progenitor cells (PBPC) have supplanted bone marrow in autologous and allogeneic tran
16 s not particularly successful because it was supplanted by (18)F-FDG imaging with positron tomography
17 inly species of the Lactobacillus genus) are supplanted by a diverse array of anaerobic bacteria.
18 of all eukaryotic mitochondria and has been supplanted by a host-derived system multiple times in di
19 ptive for the circumstances and needed to be supplanted by a more collaborative solution-focused appr
20 tive care for patients with HIV/AIDS must be supplanted by a more integrated model to provide compreh
22 to relieve epigenetic repression and can be supplanted by agents that hyperacetylate histones and de
23 male mounts rewarding: sexual receptivity is supplanted by aggression and a coincident decline in dop
24 ctomy, an approach that has now been largely supplanted by an array of techniques referred to as the
25 state interaction with the cis-glutamine is supplanted by an elaborate polar network involving criti
26 2p70 and IFN-gamma subsides after 3 wk to be supplanted by an IL-23/IL-25 response beginning after 4-
30 f terminally differentiated cells, which was supplanted by cells that exhibited nuclear SOX9 labeling
31 ventilation/perfusion scintigraphy has been supplanted by computed tomographic pulmonary angiography
32 n the past decade, the barium enema has been supplanted by CT colonography as the major imaging test
33 e protective microbial environment have been supplanted by culture-independent microbiome science, di
35 F-beta on I alpha locus transcription can be supplanted by expression of a heterologous minigene at t
36 low from H(2) to NADH to the reductases were supplanted by extracellular electron flow with the addit
37 nnate inflammatory state also was temporally supplanted by immunoregulatory processes, suggesting a m
39 ogy of 'renal replacement therapy' should be supplanted by more appropriate terminology, 'renal suppo
40 rage retirement of approaches that have been supplanted by more reliable and selective tools for dete
41 thods (e.g., the yeast two-hybrid) have been supplanted by more sophisticated chemical approaches tha
43 se using conventional approaches, a strategy supplanted by one based on the genetic alterations of th
51 sible for adaptive immunity was sequentially supplanted by the concept of separate T and B lymphocyte
52 ial reaction of oxygen gas at the cathode is supplanted by the high-voltage reduction of cerium ammon
54 nd time-intensive and consequently are often supplanted by the more rapid and inexpensive enzyme immu
55 During hypoxia, fictive eupneic activity is supplanted by the neural correlate of gasping, which is
56 r Ca(2+)-activated Cl(-) channels, have been supplanted by the newly discovered anoctamins and now ho
58 pic drug discovery approach has been largely supplanted by the powerful but reductionist approach of
60 limited and short-lived protection, has been supplanted by the superior recombinant zoster vaccine (R
64 the concept of 'the' sodium channel has been supplanted by understanding that excitable cells in mamm
65 ed into clinical practice and may eventually supplant certain traditional tests that have greater var
66 same time, quantum computing likely will not supplant classical computing in the foreseeable future-a
67 LMs) have recently demonstrated potential to supplant classical protein database search methods based
69 er RNA (mRNA) profiling has been proposed to supplant conventional methods for body fluid identificat
71 and whether noncovalent BTK inhibitors will supplant covalent BTK inhibitors as upfront treatment op
72 new and potentially valuable information to supplant current rules based on consensus of expert opin
73 deletion, as proposed here, could enhance or supplant current tests, which define D2 alleles on the b
74 ogenomics offers the potential to enhance or supplant currently applied prognostic criteria for use i
75 a closed-loop recyclable plastic that could supplant currently used (and often unrecycled/unrecyclab
76 e recommendations be used to support and not supplant decisions in individual patient management.
79 uggest that generalization is implemented by supplanting dynamic processing conducted in the PPC with
83 gical doses, the plasma leptin concentration supplants FM as an independent determinant of EE in both
84 uorouracil with leucovorin (FU/LV), and have supplanted FU/LV as the standard systemic approach for m
85 ions: uncertainties in climate forcings have supplanted global climate sensitivity as the predominant
86 ) that structural priming experiments should supplant grammaticality judgments for testing linguistic
87 This work examines several approaches to supplant H(2)S as a deprotection reagent in favor of a s
88 from our laboratory showed that Ez does not supplant H2z in the contribution to lupus-like disease.
91 all cells within a tumour, may instigate VM, supplant host-derived endothelium, and form PECAM1-depen
95 cus on readiness as self-regulation does not supplant interest in the development of acquired ability
96 e initial therapy of choice in this disease, supplanting interferon and allogeneic stem cell transpla
99 percutaneous interventional treatments have supplanted many surgical approaches for simple lesions,
101 ssays, which are available in kit form, have supplanted microbiological assays in many clinical labor
102 context-based learning and estimation should supplant models of adaptive processes with different lea
105 hoice stimuli appeared, feature-based coding supplanted order-based coding, and position-based coding
106 id and lymphoid lineages at 1 month but were supplanted over time by multilineage clones, initially m
112 lian cells express RAD52, but BRCA2 may have supplanted RAD52 in mediating RAD51 loading onto ssDNA.
113 Cross-sectional imaging techniques have supplanted radiographic imaging for both urinary and gen
115 cells is lacking, and the idea that they can supplant reactive-oxygen-species (ROS)-scavenging enzyme
118 e centrifugal microfluidic ELISA system that supplants repetitive pipetting with rotationally control
119 e (TMD) semiconductors as a future option to supplant silicon transistors at sub-10nm physical gate l
120 ombined radioisotope therapy will ultimately supplant single radioisotope therapy, much as combinatio
124 rship" of valuable food items rather than by supplanting subordinates according to well-defined domin
125 scatheter aortic valve replacement (TAVR) is supplanting surgical aortic valve replacement (SAVR) and
126 potential of DTA to augment or perhaps even supplant suture repair and warrant further exploration.
127 y for many renewable sources of energy, have supplanted synchronous generators in ever growing number
129 chinery and that these pathways synergize to supplant the adhesion requirements of specific cell cycl
130 ne and in many instances this derivative can supplant the bromo and fluoro analogues that are more cu
133 increasingly supplement and, in some cases, supplant the genetic variation that occurs naturally.
134 tissues condition macrophage activities and supplant the influence of macrophage origins in favor of
140 kin 17-producing T(H)-17 lineage appeared to supplant the pre-eminence of T(H)1 cells in promoting au
141 c cascade, mediated by vicuna density, could supplant the predator-induced trophic cascade, mediated
142 disrupted lymphocyte trafficking, the BM can supplant the secondary lymphoid tissue either as a site
145 nary revascularization did not substantially supplant the use of antianginal medications, which were
147 e SARS-CoV-2 spike (S) protein variant D614G supplanted the ancestral virus worldwide, reaching near
149 of functional selectivity has now thoroughly supplanted the previously entrenched notion of intrinsic
150 f the product to decrease donor exposure has supplanted the use of fresh red blood cells with each tr
152 hases and diverse mutant enzyme libraries by supplanting the common practice of using larger scale re
153 ld meet 80% of anticipated 2040 power demand supplanting the country's current reliance on coal.
155 c complexes act as iron siderophore analogs, supplanting the natural iron uptake of most bacteria.
156 the conceptual foundations of microbiology, supplanting the notion of species genomes with fixed gen
157 oietic stem cells from intraembryonic sites, supplanting the original primitive population of extraem
158 e adaptive radiation of early vertebrates by supplanting the skin as the dominant site of gas exchang
159 g into the TREX mRNA export complex, thereby supplanting the splicing requirement for efficient mRNA
160 contraindications, a case cannot be made for supplanting the traditional on-pump CABG technique with
164 multifaceted viral protein that functionally supplants the cellular cap-binding complex is a unique s
166 ith research staff from their own home often supplants the need for many or all on-site clinic visits
168 Our hypothesis supplements, but does not supplant, the traditional view of carcinogenesis in whic
169 hloroplast tRNA genes that have functionally supplanted their mitochondrial counterparts, appear to b
170 is-acting RNAs that in some cases completely supplant these factors by recruiting and activating the
171 ioxidant assays" (e.g., the DPPH assay) have supplanted these in popularity, they are generally very
172 on across diverse tumor types is unlikely to supplant tissue-of-origin considerations in addressing c
173 s and bioprinted 3D tissues are beginning to supplant traditional 2D cell cultures and preclinical an
174 rrying microparticles are envisioned to help supplant traditional drug delivery methods and enhance e
178 , with hybrid systems augmenting rather than supplanting traditional surveillance systems, and better
180 -cyclooctene-containing primary alcohols can supplant water as the nucleophile in the PLD active site