ライフサイエンスコーパス: suppressive

1 reated and pembrolizumab-treated iTregs were suppressive.

2 vironment that is highly fibrotic and immune suppressive.

3 ous cell carcinomas, in which Notch is tumor suppressive.

4 pore-defective GSDME proteins are not tumour suppressive.

5 yet other evidence supports them being tumor suppressive.

6 This seizure-suppressive action during daily stimulation remained sta

7 in PP2A Aalpha scaffold abrogates the tumor suppressive actions of PP2A, thereby potentiating oncoge

8 pressor complex (E2F-Rb-HDAC) to reverse its suppressive activities and facilitate downstream gene ex

9 ed high levels of Foxp3 and exhibited potent suppressive activities both in vitro and in vivo.

10 The lack of mechanistic insight into MDSC suppressive activity and a marker for their identificati

11 3(flox/flox)/CD4-cre(tg/wt) mice had similar suppressive activity as Tregs from CD83(flox/flox)/CD4-c

12 T(reg) cell function to increase or decrease suppressive activity in autoimmunity and cancer, respect

13 The main mechanism of FATP2-mediated suppressive activity involved the uptake of arachidonic

14 tions of the serine trio restored the tumour suppressive activity of extracellular oncogenic mutants.

15 ever, CD137 was critical for the in vivo T1D-suppressive activity of FOXP3(+) Tregs, suggesting that

16 HOXB13 deletion demonstrates that the tumor-suppressive activity of MEIS1 is dependent on HOXB13.

17 Deletion of FATP2 abrogated the suppressive activity of PMN-MDSCs.

18 ons, as well as its important impacts on the suppressive activity of regulatory T cells.

19 omplex is required for the contact-dependent suppressive activity of Tregs, including suppression of

20 ked mole-rat p53 retains its canonical tumor suppressive activity.

21 TSDR demethylation, enhanced stability, and suppressive activity.

22 tratumoral CD4+ effector Tregs with superior suppressive activity.

23 d therapies for the oncogenic, but not tumor-suppressive, activity of BRD4.

24 Cs and found that it mediated opposing tumor-suppressive and -promoting effects on ASCL1lo and ASCL1h

25 D4(+) T helper 2 (Th2) cell responses, since suppressive and activating roles have been reported.

26 n of inflammatory mediators mobilizes immune-suppressive and angiogenic myeloid cells, emerging studi

27 st in cancers because it can play both tumor suppressive and oncogenic roles.

28 hagy in cancer development being both tumour suppressive and oncogenic, sequentially.

29 insic effects of autophagy can be both tumor suppressive and tumor promotional.

30 a pleiotropic protein, promoting both tumor-suppressive and tumor-promoting activities.

31 s, characteristics associated with maximally suppressive, anti-inflammatory T(reg) cells.

32 ) PJI-related death; or (3) use of long-term suppressive antibiotics.

33 erized pathway of adenocarcinoma escape from suppressive anticancer therapy.

34 vertically infected with HIV-1 who initiated suppressive antiretroviral therapy (ART) regimens in inf

35 size of the latent reservoir in patients on suppressive antiretroviral therapy (ART).

36 om people living with HIV who were receiving suppressive antiretroviral therapy.

37 CD4(+) T cell subsets isolated from PLWH on suppressive ART (n = 8).

38 that more than 70 years of continuous, fully suppressive ART are needed to eliminate the HIV reservoi

39 articularly useful for screening children on suppressive ART for enrolment into therapeutic vaccine t

40 immunodeficiency syndrome (AIDS) or death on suppressive ART were calculated by PIR status.

41 fferent couples (HIV-positive partner taking suppressive ART) who reported condomless sex, whereas th

42 the dynamics of the HIV DNA reservoir during suppressive ART, even when ART is initiated during the e

43 PORTANCE In people living with HIV (PLWH) on suppressive ART, latent HIV can be found in a diverse ra

44 es, may sustain HIV tissue reservoirs during suppressive ART, suggesting future cure strategies shoul

45 We show that in CD4(+) T cells from PLWH on suppressive ART, the use of the coreceptor CXCR4 was pre

46 ize proviral sequences after 6 to 9 years on suppressive ART.

47 the dynamics of the HIV DNA reservoir during suppressive ART.

48 immune response (PIR) in children receiving suppressive ART.

49 T cell exhaustion and a suppressive bone marrow microenvironment have been impli

50 We here demonstrate suppressive but not curative effect of remdesivir in an

51 Significantly lower concentrations of tumor-suppressive butyrate (22.5 +/- 3.1 compared with 47.2 +/

52 NOX4 is critical for maintaining the immune-suppressive CAF phenotype in tumors.

53 hereas ectopic USP11 expression enhanced the suppressive capacity and lineage commitment of these cel

54 T(regs), we found no differences in in vitro suppressive capacity nor in their ability to limit the e

55 The suppressive capacity of myeloid cells was tested in cocu

56 o show that this cytokine enhanced the viral suppressive capacity of NK cells from HD and elite contr

57 s, compromised proliferation, and diminished suppressive capacity of Tregs.

58 human peripheral blood exhibited more potent suppressive capacity than Notch-1(high) Tregs.

59 rs, yet without developing enhanced in vitro suppressive capacity.

60 t persist in HIV-infected individuals during suppressive cART are translationally competent and produ

61 During suppressive cART, integrated HIV-1 DNA copies decreased

62 TSA-reactive CD4(+), CD8(+) T cells, and TSA-suppressive CD4(+) T cells can be detected and separated

63 We show that highly suppressive CD4(+)FOXP3(+)TNFR2(+) Tregs contribute to t

64 erived suppressor cells (MDSCs) are immature suppressive cells found in tumors and immunological nich

65 showed that blood monocytic myeloid-derived suppressive cells mediate the Delta9-THC-induced early r

66 their viral kinetics and persistence during suppressive combination antiretroviral therapy (cART) an

67 phenotype in CD8(+) T cells and was equally suppressive compared to PD-1 signaling; (2) PD-L1(+) T c

68 Proliferation marker Ki67 and suppressive competence markers Foxp3 and CTLA4 were indu

69 ut Model, to characterize the excitatory and suppressive components of RGC receptive fields.

70 chy, particularly in terms of excitatory and suppressive contributions.

71 chy, particularly in terms of excitatory and suppressive contributions.SIGNIFICANCE STATEMENT Using s

72 We established that the immune-suppressive cytokine interleukin-27 (IL-27) is elevated

73 t of equilibrium by a simple low-dimensional suppressive drive might ameliorate inference bias.

74 A global suppressive effect impacting ongoing motor responses and

75 The suppressive effect is mediated through direct phosphoryl

76 tion at 1 mm glucose and did not prevent the suppressive effect of 7 mm glucose.

77 However, the suppressive effect of bacterial-derived histamine on BAL

78 -binding activity in the retina and that the suppressive effect of diabetes on Nrf2 activity is absen

79 This suppressive effect of EVs was lost when they were obtain

80 The suppressive effect of GZMB(+) B cells was partially GZMB

81 out NK-A receptor antagonist (NK2), showed a suppressive effect of HMGB1 on hematopoietic progenitors

82 TAT1, SMCHD1, and PML may partly mediate the suppressive effect of IFN-alpha on hepadnaviral cccDNA t

83 Consistent with a potential tumor-suppressive effect of Norrin suggested by the tumor outc

84 elated lung cancer mouse models revealed the suppressive effect of PIERCE1 knockout in urethane- and

85 is on a unique domain, and a potential tumor-suppressive effect of Pol epsilon in curbing genome re-a

86 r cells quantitatively, but diminished their suppressive effect on CD8+ proliferation.

87 they resorb less and have in vitro an immune-suppressive effect on Cx3cr1(neg) i-OCLs, mediated by PD

88 provide evidence that DDB2 has a significant suppressive effect on expression of the endogenous marke

89 MDM model, we show that ZL0580 also induces suppressive effect on HIV in human primary macrophages.

90 Notably, this tumour-suppressive effect was completely abolished by the gut m

91 absence of uroS In addition, this DeltauroS suppressive effect was enhanced by the deletion of the y

92 tion, invasion, and tube formation, and this suppressive effect was relieved by HIV Tat.

93 ng factor, SFA-1, similarly exerts an immuno-suppressive effect, working downstream or parallel to RN

94 tumour organoids it had a pronounced tumour-suppressive effect.

95 underlying basal cells, constituting a tumor-suppressive effect.

96 ld improve immune function, counteracting LA suppressive effects in the immunosuppressive phase of se

97 ogical mTOR inhibition potently enhanced the suppressive effects of alpelisib on cancer cell prolifer

98 Our study reveals that previously described suppressive effects of CB-LDG on CD4(+) T cell prolifera

99 Moreover, the fear-suppressive effects of FAAH overexpression were also mit

100 ral circuits and cell types that mediate the suppressive effects of GLP-1R agonists on cocaine-seekin

101 Asxl2DeltaLysM mice were protected from the suppressive effects of HFD, a phenomenon associated with

102 central role for EBV in mediating the tumour suppressive effects of MAOA and that loss of MAOA could

103 d HIC1 overexpression phenocopied the growth suppressive effects of MDFIC in HCT116 cells.

104 Mechanistically, the tumour-suppressive effects of mutant p53 were driven by disrupt

105 Forced ASCL1 expression reversed the tumor-suppressive effects of Norrin in ASCL1lo GSCs.

106 P) ZMAT3 is important in mediating the tumor-suppressive effects of p53.

107 , HDAC6, or HDAC8 inhibition, reproduced the suppressive effects of pan-HDACi on the inflammatory gen

108 iomas and confirm in vivo differential tumor suppressive effects of Pten between these tumors.

109 y pifithrin-alpha caused abrogation of tumor-suppressive effects of Rig-G in lung cancer.

110 is highly effective in mitigating the marrow-suppressive effects of sublethal and lethal TBI in mice.

111 ells in response due at least in part to the suppressive effects of the chronic infection milieu.

112 f profibrotic fibroblasts and by eliminating suppressive effects on adaptive immunity.

113 desensitization, and this leads to long-term suppressive effects on allergic disease without eliminat

114 The L512P mutation was verified for its suppressive effects on Fgprp4, suggesting that mutations

115 f an inhibitory role for these 2 CLRs in Msg-suppressive effects on host cell immune response.

116 s, 5-HT input provides balanced but distinct suppressive effects on ongoing and evoked activity compo

117 , LPS-induced ATP accumulation exerted these suppressive effects on T cells by activating the puriner

118 e show that serotonergic input has separable suppressive effects on the gain of ongoing and evoked vi

119 tes the pathway in stroma to drive its tumor suppressive effects-a novel role for IHH in the lung.

120 w mechanism by which PRDM16 exerts its tumor suppressive effects.

121 This immune suppressive environment promotes gastric cancer lung met

122 preferentially in areas with low content of suppressive epigenetic marks.

123 Re-expression of histone H1.0, a tumor-suppressive factor that inhibits cancer cell self-renewa

124 SC counts correlated with higher circulatory suppressive factors arginase-1 and interleukin-10, and l

125 antigen presenting cells via upregulation of suppressive factors such as checkpoint molecules.

126 nse dissociation appears to rely on enhanced suppressive feedback between regions and reveals a previ

127 severity, appeared to result from amplified suppressive feedback from MT+ to V1, and was not present

128 biological accounts of selection-independent suppressive filtering in attention.SIGNIFICANCE STATEMEN

129 and T(EFF) cells, in turn driving increased suppressive function and lineage commitment in thymic-de

130 turnover provides a rationale for its tumor suppressive function and reveals that in PTPRK-RSPO3 rec

131 1A-deficiency lead to loss of TGF-beta tumor suppressive function and that inactivation of ARID1A/TGF

132 hanisms underlying Treg cell homeostasis and suppressive function are still not fully understood.

133 We found that Tfr cells have a program for suppressive function fine-tuned by tissue microenvironme

134 er tumors, here we show that CIC has a tumor suppressive function in GBM through an alternative mecha

135 etic signatures to induce and maintain their suppressive function in the context of inflammation and

136 owever, HDAC10(-/-) Treg exhibited increased suppressive function in vitro and in vivo.

137 Their immune suppressive function is attributed to relatively rare po

138 lyze Ras-GTP to Ras-GDP, suggesting that its suppressive function is independent of Ras signaling.

139 immunity due to systemic impairment of their suppressive function limits its therapeutic potential.

140 ignaling via CRTH2 was found to diminish the suppressive function of CRTH2(+) Tregs which partially n

141 GDH regulation that contributes to the tumor-suppressive function of Parkin and identified Parkin dow

142 Although the tumor-suppressive function of PTEN has mainly been attributed

143 egion (TSDR) in the mouse Foxp3 gene and the suppressive function of sorted induced Tregs.

144 in axis as a molecular mediator of the tumor-suppressive function of WWOX.

145 d from aNotch-1-treated mice showed enhanced suppressive function on a per-cell basis, confirmed with

146 3 protein levels and caused defects in their suppressive function that led to spontaneous autoimmunit

147 enesis in certain contexts despite its tumor-suppressive function through inhibition of growth-promot

148 Rapamycin is able to affect Treg suppressive function via a FOXP3-independent mechanism,

149 d that specific CD8 Tregs from NOD mice lack suppressive function, representing a previously unreport

150 reduction in both Treg frequencies and their suppressive function, which was prevented by the additio

151 ding to miR-519e-5p and destroying its tumor suppressive function.

152 ssion of GILZ in mature Tregs inhibits their suppressive function.

153 ion without changes in genes associated with suppressive function.

154 e for its transcriptional activity and tumor suppressive function.

155 P3(+) Tregs, but psoriatic Tregs had reduced suppressive function.

156 lation, enhancing Treg lineage stability and suppressive function.

157 establishment and stability of identity and suppressive function.

158 bition of the PGE2/p50/NO axis prevents MDSC-suppressive functions and restores the efficacy of antic

159 Importantly, NR4A3 exhibited tumor suppressive functions both in p53-dependent and independ

160 miR124 axis enhances the differentiation and suppressive functions of MDSCs and may be a potential ta

161 tudies that establish oncogenic versus tumor-suppressive functions of two BRD4 isoforms in the regula

162 icantly reduced the MDSC frequency and their suppressive functions.

163 is, and highlighted their oncogenic or tumor suppressive functions.

164 ment and have both tumor-promoting and tumor-suppressive functions.

165 s that can translate into tumor-promoter or -suppressive functions.

166 cells promoted the MDSC differentiation and suppressive functions; conversely, silencing of HOTAIRM1

167 ospho-STAT1 activation, turning on its tumor-suppressive gene-expression program and turning off STAT

168 have been conducted, new oncogenic or tumor suppressive genes need to be detected because a large pr

169 targets a suite of pro-apoptotic and tumour suppressive genes, including tumour suppressor candidate

170 DB1 via the downregulation of critical tumor-suppressive genes.

171 with higher expression of lymphocytic immune suppressive genes.

172 ubiquitination and degradation of the tumor suppressive histone variant macroH2A1, leading to enhanc

173 e metabolism of tumors and the metabolism of suppressive immune cells.

174 ed a unique immune signature that suggests a suppressive immune phenotype and reduced CD11C(+) autoim

175 tory factors (TNF-alpha, IL-1beta, IL-5) and suppressive immune populations (myeloid-derived suppress

176 es can reduce pro-inflammatory cytokines and suppressive immune populations.

177 f balanced vaccine-induced activating versus suppressive immune responses in affording protection fro

178 (BRD4-S) is oncogenic while BRD4-L is tumor-suppressive in breast cancer cell proliferation and migr

179 olizumab-treated iTregs were relatively less suppressive in higher Treg ratios and failed to produce

180 lthough wild-type (WT) PLP-CD8 were robustly suppressive in IFN-gammaR-deficient mice, IFN-gammaR-def

181 hich is released during flight, reverses the suppressive influence of background motion, rendering bo

182 rning optimizes perceptual decisions through suppressive interactions in decision-related networks.

183 Global deficiency of antiviral tumor-suppressive interferon regulatory factor 1 (IRF-1) selec

184 myeloid-derived suppressor cells, the immune-suppressive interleukin-10 (IL-10) cytokine, and the dow

185 A cytoplasmic tumor-suppressive lncRNA interacts with and inhibits a major k

186 ssing development and/or expansion of immune-suppressive lymphocytes (Bregs and Tregs).

187 ls, lowered the hypoxia level, decreased the suppressive lymphocytes such as tumor associated macroph

188 reduce TAMs, especially the protumor, immune-suppressive M2 TAMs.

189 ammed death ligand-1 (PD-L1)-positive immune-suppressive macrophages than those with WT ER.

190 ntly, virtual lesion of pSTS eradicated this suppressive mechanism and restored object weight-driven

191 escence is a primary aging process and tumor suppressive mechanism characterized by irreversible grow

192 lated in many types of cancer, and its tumor-suppressive mechanism is poorly defined.

193 e results provide evidence of a novel immune suppressive mechanism of glucocorticoids involving the t

194 iven by object weight but easily masked by a suppressive mechanism reflecting the correctness of weig

195 ysiologically, senescence serves as a tumour-suppressive mechanism that prevents the expansion of pre

196 gated in 24 humans (14 females) whether this suppressive mechanism was driven by higher-order cortica

197 ulatory T lymphocytes (Tregs) display immuno-suppressive mechanisms and tissue repairing functions, w

198 croptosis need to overcome these independent suppressive mechanisms before plasma membrane disruption

199 e significance of potential immune promotive/suppressive mechanisms induced by MSCs loaded with oncol

200 can adopt tissue- or immune-context-specific suppressive mechanisms is unclear.

201 gest that a loss of NOD-LNSC MHC-independent suppressive mechanisms may contribute to diabetes develo

202 90 days-remaining inactive without receiving suppressive medications at all of the last visits.

203 ake(8-12), our results suggest that pathogen-suppressive microbiome members produce siderophores that

204 al therapeutic targets to remodel the immune-suppressive microenvironment in patients with lung cance

205 Recognising that the immune suppressive microenvironment promotes tumour growth in H

206 or efficacy through modulation of the immune suppressive microenvironment, leading to an increased re

207 ed CCL3 production in turn creates an immune-suppressive milieu by altering T cell subpopulations.

208 The tumor-suppressive miR-186 that is downregulated in neuroblasto

209 ated with known PDAC pathways, loss of tumor-suppressive miRNA binding sites, and increased heterogen

210 ominantly regulates expression of metastasis-suppressive miRNAs in the 14q32 cluster.

211 genic activity without interfering its tumor suppressive MMP-inhibitory function.

212 In the tumour-suppressive mode, mutant p53 eliminated dysplasia and tu

213 regulatory T cells and expression of immune-suppressive molecules similar to escape mechanisms seen

214 erapies by modifying cells to express immune-suppressive molecules such as PD-L1 and CTLA4-Ig.

215 llergen and lung inflammation, expression of suppressive molecules, and induction of regulatory T cel

216 parts, IRF4+ Tregs expressed a vast array of suppressive molecules, and their presence correlated wit

217 P3(+)) and characteristically display immune-suppressive molecules, including the coinhibitor recepto

218 Further characterization of the intragenic suppressive mutations located in the RRS1-R TIR domain r

219 ve tumor microenvironment by decreasing both suppressive myeloid and plasma cells in the tumor.

220 The critical role of suppressive myeloid cells in immune regulation has come

221 anced expression of CXCL3 and recruitment of suppressive myeloid cells, and subsequent resistance to

222 he immune receptor TIGIT and the deletion of suppressive myeloid populations appear attractive, parti

223 t STING deficiency contributes to the immune suppressive nature of MCCs.

224 Leveraging well-characterized suppressive neural circuits in the visual system, we use

225 ycle, cultivating a br-met-promoting, immune-suppressive niche.

226 DTG for all patients, including patients on suppressive NNRTI-based ART.

227 on the colonic microbiota that produce tumor-suppressive or -promoting metabolites.

228 ived exosomes towards tumor cells can induce suppressive or active immune responses.

229 -revealing a dedicated tRNA-regulated growth-suppressive pathway for oxidative stress response.

230 s are also potentially susceptible to immune-suppressive pathways in the tumor microenvironment that

231 ion provokes alterations in inflammatory and suppressive pathways that potentially affect the functio

232 rophages to express MARCO and gain an immune-suppressive phenotype through the release of IL37.

233 es and show that inert tumors have an immune-suppressive phenotype with numerous exhausted CD8 T cell

234 dendritic cells (DCs) into a tumor-promoting suppressive phenotype.

235 polarized to a mixed proinflammatory/immune-suppressive phenotype.

236 racy of scene segmentation is sharpened by a suppressive process that resolves local ambiguities by a

237 -based invigorating processes vs. peripheral suppressive processes.

238 We demonstrate layer-specific suppressive processing within visual cortex, as indicate

239 nstrate that oncogenic KRAS drives an immune suppressive program in colorectal cancer by repressing I

240 to control expression of a plethora of tumor-suppressive programs.

241 These Tregs maintained their suppressive properties as well as their phenotype in a h

242 ficient T(reg) cells demonstrated attenuated suppressive properties in vivo and facilitated tumor reg

243 Additionally, we show new tumour suppressive properties of RBMS1 whose observed loss may

244 its ablation restored Il33(-/-) T(reg) cell-suppressive properties.

245 led to increased protein levels of the tumor-suppressive protease prostasin.

246 ation, and altered T cell differentiation to suppressive regulatory phenotypes.

247 eatment-associated toxicity and expansion of suppressive regulatory T cells (Tregs) limit its use in

248 ressive immune responses are counteracted by suppressive rejoinders.

249 on non-Th17 effector CD4+ T cells to induce suppressive resistance, and this resistance can be rever

250 NTHi infection in the ME induces the immune suppressive response by inducing the T-reg cell populati

251 ield, we found no amplifying responses, only suppressive responses to the non-preferred motion direct

252 astoma progression, consistent with a tumour suppressive role for AHR.

253 ast cancer datasets, consistent with a tumor-suppressive role for PADI4 in estrogen receptor-positive

254 These data further support a suppressive role for PL in cocaine seeking by implicatin

255 ancer patients, our findings suggest a tumor-suppressive role for steroidal signaling by promoting po

256 l, our results demonstrate that Gal2 plays a suppressive role in colon tumor growth and highlights th

257 e regulator of Notch signaling, could have a suppressive role in T-ALL.

258 ors and demonstrates a mechanistic and tumor suppressive role of ATF3.

259 Our results provide evidence for a tumour suppressive role of kappaB-Ras proteins and highlight lo

260 They also connect the tumor-suppressive role of KDM6A deficiency with a cell-specifi

261 F8b-deficient MERS-CoV further confirmed the suppressive role of ORF8b in type I IFN induction and it

262 our data provide new insights into the tumor suppressive role of PARK2 in malignant melanoma and unco

263 Moreover, the suppressive role of TET1 in the thermogenic gene regulat

264 Despite the tumor-suppressive role of TGFbeta signaling, transcriptome pro

265 intrinsic coagulation pathway; (4) a local, suppressive role of the anticoagulant thrombomodulin/pro

266 These findings not only determine a suppressive role of the stress response regulators JNK1/

267 Consistent with the tumor-suppressive role of TP53, patients harbor both mono- and

268 molecules (JAM) in cancer suggested a tumor-suppressive role where decreased expression led to incre

269 ly, however, SETDB1 can also acquire a tumor-suppressive role, depending on cancer type and stage.

270 can either have a tumour-promoting or tumour-suppressive role.

271 on mutations in lung cancer, but their tumor-suppressive roles are poorly characterized.

272 se is yet licensed, partly because of immune suppressive side-effects beyond control of islet autoimm

273 e, could help to recreate a similar melanoma-suppressive signaling environment in melanoma high-risk

274 ng macrophages more susceptible to receiving suppressive signals from adenosine.

275 l, and biological characteristics of disease-suppressive soils.

276 Suppressive soluble factors, cytokines, anti-HLA antibod

277 applications for evaluating eradicative and suppressive strategies against the HIV reservoir, includ

278 y is critical to investigate eradicative and suppressive strategies that target HIV-1 Env.

279 e response by inducing development of immune-suppressive T cells.

280 , the precise chemotherapy instead induced a suppressive tendency of immune system, manifested by a s

281 of patients treated with (selective) immune suppressive therapies for MS.

282 Thus, the clinical use of antivirals as suppressive therapy for EBV lytic reactivation may aid e

283 rsons with HIV-1 infection receiving virally suppressive therapy.

284 ar to be small across sexes during long-term suppressive therapy.

285 y serve as a facile platform to modulate the suppressive TME, and enable in situ personalized cancer

286 both tumor monocytes and macrophages from a suppressive to a proinflammatory, immunostimulatory phen

287 ome circumstances, EVs were also found to be suppressive to disease, but more often promote inflammat

288 We reveal that loss of the tumour suppressive transcription factor Elf5 in TNBC cells acti

289 p53 is an intensely studied tumor-suppressive transcription factor.

290 EST corepressor 1 (CoREST) in promoting Treg suppressive transcriptional and functional programs.

291 SKP2) by the more widely expressed and tumor-suppressive TRbeta1.

292 methylation inhibitors capable of inhibiting suppressive trimethylation marks.

293 This may be because of a suppressive tumor immune microenvironment and lack of re

294 ibute to tumor immune evasion by promoting a suppressive tumor microenvironment (TME).

295 mportantly, IPI-549 NP treatment reduced the suppressive tumor microenvironment by decreasing both su

296 itumoral effect, even within a highly immune-suppressive tumor microenvironment.

297 to evade immune surveillance and sustain the suppressive tumor microenvironment.

298 notherapy could enable physicians to obviate suppressive tumors while avoiding systemic treatments th

299 treating pancreatic cancer and other immune-suppressive tumors.

300 Expanded GPA33(high) Treg cells are suppressive, unable to produce proinflammatory cytokines