ライフサイエンスコーパス: suppressor

1 ctivators, or filaminA, an integrin activity suppressor.

2 , including those governed by the TP53 tumor suppressor.

3 ther supporting that DCC is a melanoma tumor suppressor.

4 ranscription coactivator and the Warts tumor suppressor.

5 amily member and potent tumor and metastasis suppressor.

6 vate carrier 1 (MPC-1) appears to be a tumor suppressor.

7 ely due to additional sources created by the suppressor.

8 mutated in cancers and functions as a tumor suppressor.

9 gene in prostate cancer and is a gatekeeper suppressor.

10 ,6), suggesting that GSDME might be a tumour suppressor.

11 y of NF2 patients show loss of the NF2 tumor suppressor.

12 s of drive can lead to selection of unlinked suppressors.

13 y the circadian clock are oncogenes or tumor suppressors.

14 pt Grb2-SOS1 association, can serve as tumor suppressors.

15 ancer genes and reduced expression of cancer suppressors.

16 pression levels of proto-oncogenes and tumor suppressors.

17 et-to-be-characterized potential ccRCC tumor-suppressors.

18 ery of a novel function of G protein pathway suppressor 2 (GPS2) in promoting erythroid differentiati

19 NME1 is a metastasis suppressor, a class of proteins which inhibits metastati

20 s on MBNL1 may therefore, yield potent tumor suppressor activities, uncovering new therapeutic opport

21 Here, we report novel tumour suppressor activity for the Drosophila Argonaute family

22 while a subset had clinically relevant tumor-suppressor activity.

23 The tumor suppressor adenomatous polyposis coli (APC) is frequentl

24 e vesicle-trafficking regulator GNOM and its suppressor, ADENOSINE PHOSPHATE RIBOSYLATION FACTOR GTPa

25 seeds are insensitive to the triploid block suppressor admetos.

26 ATM kinase is a tumor suppressor and a master regulator of the DNA damage resp

27 28), which has been reported as both a tumor suppressor and an oncogene.

28 yposis coli (APC), a protein with both tumor suppressor and cytoskeletal functions, concentrates at t

29 fold increase in the levels of several tumor suppressor and DNA repair gene protein products (GP)s at

30 The tumor suppressor and FERM domain protein Neurofibromin 2 (NF2)

31 In addition, Klotho is also a tumor suppressor and has beneficial roles in multiple organs.

32 ings reveal that RGS12 is an essential tumor suppressor and highlights RGS12 as a potential therapeut

33 gulated by the von Hippel-Lindau (VHL) tumor suppressor and is highly expressed in clear cell renal c

34 We also establish H1 as a bona fide tumour suppressor and show that mutations in H1 drive malignant

35 findings indicate that KMT2D is a lung tumor suppressor and that KMT2D deficiency confers a therapeut

36 ation of oncogenes and upregulation of tumor suppressors and apoptosis.

37 r development, occurring in oncogenes, tumor suppressors, and dual role genes.

38 l pairs, including three highly active amber suppressors, and evolve new amino acid substrate specifi

39 oth human TSC1 and TSC2 are important tumour suppressors, and mutations in them underlie the disease

40 h to colorectal cancer through loss of tumor suppressors APC and TP53 and gain of the KRAS oncogene.

41 In addition, jasmonate levels in the fsh suppressor are significantly lower than in bp, which is

42 describe a mechanism by which the ARF tumor suppressor binds PPM1G to negatively regulate its coacti

43 r, we found that the co-binding of the tumor suppressor BRCA1 and RNA polymerase II, a well-known tra

44 elicase and interacting partner of the tumor suppressor BRCA1, is crucial for the repair of DNA inter

45 The tumour suppressor breast cancer type 1 susceptibility protein (

46 established role in inhibiting the p53 tumor suppressor by binding to MDMX and stimulating MDMX-p53 i

47 n Phosphatase 2A (PP2A) functions as a tumor suppressor by negatively regulating multiple oncogenic s

48 HIF1A can act a tumor suppressor by preventing the expression of PPP1R1B and s

49 binding protein ZFP36L1 functions as a tumor suppressor by regulating the mRNA stability of a number

50 e cancer, SPOP seems to function as a tumour suppressor by targeting several proteins, including andr

51 the clinical relevance of new putative tumor suppressors by showing these are frequently altered in p

52 ine stimulation, and suggest that this tumor suppressor can promote early premalignant epidermal lesi

53 iglioma regimens and autophagic mediators or suppressors can allow us to overcome GBM regrowth in the

54 ain-containing protein BRD9 and glioma tumor suppressor candidate region 1 (GLTSCR1) or its paralog G

55 Human (Homo sapiens) glioma tumor-suppressor candidate region gene2 (GLTSCR2) and yeast (S

56 e CXCR5IFN-gammaCD8 T cells (termed antibody-suppressor CD8 T cells) and that the quantity of CXCR5IF

57 lity of a mutant defective for the apoptotic suppressor ced-9/Bcl-2 implicating SEP-1 in execution of

58 macrophage polarization and myeloid-derived suppressor cell differentiation, respectively, most like

59 e number of granulocyte-like myeloid-derived suppressor cells (and their expression of programmed-dea

60 Granulocytic myeloid-derived suppressor cells (G-MDSCs) promote tumor growth and immu

61 ry emergence of granulocytic myeloid-derived suppressor cells (G-MDSCs) that mediated immune escape b

62 immunosuppressive cells are myeloid-derived suppressor cells (MDSC) and tumor-associated macrophages

63 The increased presence of myeloid-derived suppressor cells (MDSC) and tumor-associated macrophages

64 t of this, T-cell inhibitory myeloid-derived suppressor cells (MDSC) are gaining interest as key faci

65 Myeloid-derived suppressor cells (MDSC) are one of the major negative re

66 Our data suggest that myeloid-derived suppressor cells (MDSC) in the TME are a major source of

67 Myeloid-derived suppressor cells (MDSC) include immature monocytic (M-MD

68 umor infiltration, decreased myeloid-derived suppressor cells (MDSCs) and further decreased circulati

69 Myeloid-derived suppressor cells (MDSCs) are a group of heterogeneous ce

70 Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population

71 Myeloid-derived suppressor cells (MDSCs) are immune cells that exert imm

72 Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells tha

73 As myeloid-derived suppressor cells (MDSCs) are potent immunoregulatory cel

74 essive microenvironment with myeloid-derived suppressor cells (MDSCs) as a dominant population.

75 ont in cancer research, with myeloid-derived suppressor cells (MDSCs) as a main oncology immunotherap

76 lls and fewer Gr1(+)CD11b(+) myeloid-derived suppressor cells (MDSCs) at early time points following

77 eutrophils, and granulocytic myeloid-derived suppressor cells (MDSCs) from cancer patients extrude th

78 Myeloid-derived suppressor cells (MDSCs) increase in patients with cance

79 y decrease the population of myeloid derived suppressor cells (MDSCs) within the tumor microenvironme

80 yeloid immune cells, such as myeloid-derived suppressor cells (MDSCs), populate inflamed or cancerous

81 eneration and recruitment of myeloid-derived suppressor cells (MDSCs).

82 recruitment of granulocytic myeloid-derived suppressor cells (PMN-MDSCs) into tumor tissues, thereby

83 actions of tumor-associated myeloid-derived suppressor cells (tumor-MDSCs).

84 ich are rapidly exploited as myeloid-derived suppressor cells at the cost of tumor-reactive lymphoid

85 ay inhibition and to inhibit myeloid-derived suppressor cells in various melanoma models.

86 hing appears to be caused by myeloid-derived suppressor cells recruited to the premetastatic lungs th

87 Foxp3+ regulatory T cells (Tregs) are potent suppressor cells, essential for the maintenance of immun

88 ch as regulatory T cells and myeloid-derived suppressor cells, into the tumour microenvironment.

89 asing regulatory T cells and myeloid-derived suppressor cells.

90 egulatory, B regulatory, and myeloid-derived suppressor cells.

91 r-associated fibroblasts and myeloid-derived suppressor cells.

92 mmatory functions, miR-146a is a known tumor suppressor commonly deleted or expressed at reduced leve

93 ers or nucleic acid targets, while enzymatic suppressors covalently modify Cas ribonucleoprotein comp

94 consistency, we demonstrated that an unknown suppressor decreases miRNA-processing activity and light

95 Ptpn2, has been shown to function as a tumor suppressor during skin carcinogenesis.

96 results reveal a role of JAK3 as a potential suppressor for melanoma metastasis.

97 rts of SFOAE-frequency residuals produced by suppressor frequencies far above the SFOAE frequency are

98 Oncogene activation and loss of tumor suppressor function changes the metabolic activity of ca

99 ion of emergency granulopoiesis and leukemia suppressor function in MLL1-rearranged AML.

100 Mdm2 targeting plays a predominant tumor suppressor function in wild-type TP53 contexts, whereas

101 ovide a novel mechanism regulating the tumor suppressor function of TGFbeta in liver carcinogenesis.

102 Consistent with the tumor suppressor function of UBR5 (HYD) in Drosophila, HYD sup

103 These findings demonstrate that BRCA2 tumor suppressor function tolerates substantial reduction in f

104 ls, mRNA-containing exosomes restored tumour-suppressor function, enhanced inhibition of tumour growt

105 ive phosphorylation is a main driver of Treg suppressor function.

106 showing that Tfr cells have both helper and suppressor functions in IgE production in the germinal c

107 ranscription factor confers its potent tumor suppressor functions primarily through the regulation of

108 usual example, where inactivation of a tumor-suppressor gene and activation of an oncogene are incomp

109 g located on chromosome 10 (PTEN) is a tumor suppressor gene and one of the most frequently mutated/d

110 ings herein identify TMIGD1 as a novel tumor suppressor gene and provide new insights into the pathog

111 oncogene and inactivation of the ATRX tumor-suppressor gene correlate with high-risk disease and poo

112 Lung tumor suppressor gene Gprc5a-knockout (ko) mice are susceptibl

113 tions as a medulloblastoma oncogene or tumor suppressor gene is not known.

114 ne downregulated the expression of the tumor suppressor gene N-myc downstream-regulated gene 1 (NDRG1

115 Notably, the HIC1 tumor suppressor gene was stimulated by JMJD1A and MDFIC, but

116 l death 4 (PDCD4) is a proinflammatory tumor-suppressor gene which helps to prevent the transition fr

117 ociated mutants that arose in the DLC1 tumor suppressor gene.

118 holipase C delta 1 (PLCD1), a proposed tumor suppressor gene.

119 loss of the Neurofibromatosis 2 (NF2) tumor suppressor gene.

120 e 5-hmC in the promoter region of MGMT tumor suppressor gene.

121 m two hits to the same allele of PLCD1 tumor suppressor gene.

122 in the neurofibromatosis type 1 (NF1) tumor suppressor gene.

123 yndrome caused by mutations in the NF1 tumor suppressor gene.

124 ation and gene silencing of hemizygous tumor suppressor genes (TSG), we thus hypothesized that this e

125 hanges in the RT rate or set of driver tumor-suppressor genes (TSGs) were observed to alter the dynam

126 initiation through inactivation of two tumor suppressor genes and activation of one oncogene, account

127 n WT mice via in utero deletion of key tumor suppressor genes and serially monitored cortical epilept

128 ons can be exploited to identify novel tumor suppressor genes and to obtain a deeper characterization

129 The order in which oncogenes or tumour suppressor genes are functionally selected for in a stem

130 Cas9 system to model loss of candidate tumor suppressor genes in SCLC, and we anticipate that this ap

131 number alterations or mutations in the tumor suppressor genes RB1 and TP53.

132 to miR-486-5p-dependent modulation of tumor suppressor genes that feeds back to regulate glioma stem

133 the overexpression of DNA repair and tumour suppressor genes, rendering these genes susceptible to m

134 ut their combined role as oncogenes or tumor suppressor genes.

135 onine phosphatases are important human tumor suppressor genes.

136 nd epigenetic changes in oncogenes and tumor suppressor genes.

137 e findings reveal that mutation of the tumor suppressor HACE1 disrupts its role as a regulator of the

138 with an upregulation of caspase 3 and tumor suppressors i.e., p53, MEG3 and GAS5, in U251 cells upon

139 on receptor (AHR) pathway as a potent tumour suppressor in a SHH medulloblastoma mouse model.

140 HIF1alpha has been termed a tumor-suppressor in clear cell renal cell carcinoma (ccRCC), p

141 von Hippel-Lindau (VHL) is a critical tumor suppressor in clear cell renal cell carcinomas (ccRCCs).

142 ster regulator of liver function and a tumor suppressor in hepatocellular carcinoma (HCC).

143 ultifunctional cue netrin-1, acts as a tumor suppressor in intestinal cancer and lung metastasis by t

144 etic evidence for FBP1 as a metabolic tumour suppressor in liver cancer and establish a critical cros

145 Our findings establish IL-17RD as a tumor suppressor in mice and suggest that the protein exerts i

146 pair in human cells and functions as a tumor suppressor in mice.

147 This study identifies HRK as a novel tumor suppressor in neuroblastoma and suggests dual MEK and YA

148 h KRAS mutation and loss of the CDKN2A tumor suppressor in PDAC, clinical and preclinical studies ind

149 Forkhead box protein A1 (FOXA1), an invasion suppressor in prostate cancer.

150 R for degradation and has a role as a tumour suppressor in prostate cancer; however, in kidney cancer

151 ngs reveal a novel role for PADI4 as a tumor suppressor in regulating breast cancer stem cells and pr

152 deletion in ccRCC and that it is not a tumor-suppressor in this malignancy.

153 We discover inactivation of tumor suppressors in intron regions and that tissue type and s

154 oles of microRNA(miR)-124, a novel ER stress suppressor, in As-induced ER stress response and cytotox

155 enzyme reported as an important ferroptosis suppressor, in the pancreas of mice with cerulean- or L-

156 anscripts affecting core oncogenic and tumor suppressors, including cyclin D2 and PTEN.

157 However, another tumor suppressor, inositol-polyphosphate 4-phosphatase type II

158 Although well recognized as a tumor suppressor, involvement of PTEN mutations in mediating s

159 taneous mutations, or selection for inherent suppressors, is critical since field release studies are

160 To generate suppressor iTreg cells, cells were then differentiated i

161 ta-HPV 8E6 reduced activation of large tumor suppressor kinase (LATS), an HP kinase.

162 ion of the hippo effector kinase large tumor suppressor kinase-1 and reduces nuclear accumulation of

163 -deficient pancreatic tumors, with the tumor suppressor LATS exhibiting enhanced ubiquitin-dependent

164 at genetic deficiency of Folliculin, a tumor suppressor, leads to misconnection of blood and lymphati

165 Here, we report a DNA repair suppressor, leucine-rich repeat-containing protein 31 (L

166 sruption of the Bap1, Nf2, and Cdkn2ab tumor suppressor loci in various combinations as also frequent

167 s uncovered novel associations between tumor suppressor loss and targetable kinases.

168 vitro We conclude that loss of DAB2, a tumor suppressor, may enhance myosin VI-mediated transcription

169 re shortening is currently viewed as a tumor suppressor mechanism and should protect from cancer.

170 f microRNAs include both oncogenic and tumor suppressor microRNAs.

171 A novel tumor suppressor miR-1185-1 is involved in molecular regulatio

172 According to TCGA data, the tumor suppressor miR-200b is overedited in thyroid tumors, and

173 ravel the underlying mechanisms, we isolated suppressor mutants that can tolerate toxic serine concen

174 restricted trichome distribution involving a suppressor mutation and for a pleiotropic effect of H on

175 One line, which carries a suppressor mutation in a gene required for cholesterol s

176 otranslational folding defect by second site suppressor mutations also partially restores folding of

177 In this and other lines, two suppressor mutations confer greater improvement than one

178 Surprisingly, these suppressor mutations restored normal hypoxic sensitivity

179 egulation often affects oncogenic and tumour-suppressor networks, tumour immunogenicity and immune ce

180 by germline pathogenic variants in the tumor suppressor NF2.

181 survival due to second-site maternal-effect suppressors occur at a ~10(-5) frequency.

182 osome profiling, we show that ARF is a major suppressor of 5'-terminal oligopyrimidine mRNA translati

183 BI3 and acts upstream of the splicing factor SUPPRESSOR OF ABI3-ABI5.

184 We demonstrate that rice SMAX1 is a suppressor of AM symbiosis, negatively regulating fungal

185 of neuronal FGF2 signaling, which is a known suppressor of astrocyte activation.

186 We isolated an intragenic suppressor of atprmt3-2, which rescues the developmental

187 iquitin ligase of nuclear beta-catenin and a suppressor of colorectal cancer (CRC) growth in cell cul

188 shmania donovani involve the exploitation of suppressor of cytokine signaling (SOCS) proteins that ar

189 ion of several STAT3 target genes, including suppressor of cytokine signaling 2/3 (Socs2/3); Pim-1 pr

190 ial cells (ECs) by transcellular delivery of suppressor of cytokine signaling 3 (SOCS3) within extrac

191 act post-translationally, such as the SOCS (suppressor of cytokine signaling) family.

192 nd insulin signaling, including induction of suppressor of cytokine signaling.

193 rotein Xanthomonas outer protein N (XopN), a suppressor of early defense signaling.

194 he second division requires a lower level of Suppressor of Hairless protein, and, consequently, a low

195 A and identify hyperuricemia as an intrinsic suppressor of innate immunity, in which sUA modulates th

196 Degradation of SUPPRESSOR OF MAX2 1 (SMAX1) after ligand perception is

197 ase complex SCF(MAX2) and downstream targets SUPPRESSOR OF MAX2 1 (SMAX1) and SMAX1-LIKE2 (SMXL2).

198 secondary phloem depends on the function of SUPPRESSOR OF MAX2 1-LIKE (SMXL) genes.

199 to the homologue of the Arabidopsis thaliana Suppressor of MAX2-1 (AtSMAX1) that functions in karriki

200 osis 1 (Tsc1) gene which encodes an upstream suppressor of mTORC1.

201 ro-3-hydroxyanthranilic acid (4-Cl-3-HAA), a suppressor of NMDAR agonist quinolinic acid (QUIN), is a

202 of recent studies on FLAGELLIN SENSING 2 and SUPPRESSOR OF NPR CONSTITUTIVE 1, respectively, as examp

203 ion analysis revealed that the expression of SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (SOC1) and AP

204 Thus, COP1 is an important suppressor of pathogenic c/EBPbeta-dependent gene expres

205 y, thus validating that 4E-BP1 is a powerful suppressor of PD-linked pathogenic insults.

206 s elevated constitutive expression levels in suppressor of prosystemin-mediated responses2 (spr2), a

207 linked ALS identified the USP7 ortholog as a suppressor of proteotoxicity in the nervous system.

208 res of MEK bound to the scaffold KSR (kinase suppressor of RAS) with various MEK inhibitors, includin

209 Suppressor of site IQ electron leak and vehicle were adm

210 Suppressor of site IQ electron leak, which inhibits comp

211 V-domain immunoglobulin (Ig) suppressor of T cell activation (VISTA) is an immune che

212 tes, V-type immunoglobulin domain-containing suppressor of T cell activation (VISTA) is expressed on

213 V-domain Ig suppressor of T-cell activation (VISTA) is an immune che

214 ukaryotes, such a function was attributed to suppressor of target of Myb protein 1 (Stm1; SERPINE1 mR

215 onnexin 43) hemichannel blockade as a robust suppressor of the abnormal phenotypes in both models of

216 ition of histone deacetylase 11 (HDAC11) and suppressor of variegation 3-9 homolog 2 (SUV39H2), key h

217 identify insulin as a previously undescribed suppressor of YAP activity in insulin target cells and p

218 ), embryonic ectoderm development (EED), and suppressor of zeste 12 (SUZ12), along with a number of a

219 Overexpression suppressors of a conditional myo2 smy1 mutant identified

220 Interestingly, common genetic suppressors of abnormalities displayed by ERMES mutants

221 ive regulators of presynaptic growth and are suppressors of active zone expansion at the developing m

222 e mechanisms of stoichiometric and enzymatic suppressors of CRISPR-Cas.

223 t the isolation of MltG-defective mutants as suppressors of lethal deficits in either aPBP or SEDS/bP

224 t of CTCs may merit exploration as potential suppressors of metastatic progression.

225 mpounds were earlier identified as potential suppressors of OLIG2 dimerization and found to inhibit t

226 expressing virulence factors known as viral suppressors of RNAi (VSR).

227 In a forward mutagenesis screen for suppressors of the hpat1/3 low seed-set phenotype, we id

228 genes function as activators, modifiers, and suppressors of trh expression, which in turn results in

229 combinatorial library of oncogenes and tumor suppressors on cell growth.

230 to bind and degrade the retinoblastoma tumor suppressor or activate E2F target gene expression.

231 G4 can function either as a contextual tumor suppressor or as an oncogene, depending on the tissue be

232 , as concomitant deletion of the Trp53 tumor suppressor or Chek2 DNA damage checkpoint kinase rescued

233 s activated by TGF-beta, which determine the suppressor or enhancing activities of iTreg cells.

234 cycle arrest at G2/M, upregulation of tumor suppressor p53 and p21 protein.

235 ased acetylation and protection of the tumor suppressor p53 from degradation.

236 The tumor-suppressor p53 is a critical regulator of the cellular r

237 sordered transactivation domain of the tumor suppressor p53, alpha-synuclein, and folded ubiquitin.

238 ell stress and DNA damage activate the tumor suppressor p53, triggering transcriptional activation of

239 kinase pathway or inactivation of the tumor suppressor p53, two alterations that occur in a large ma

240 ted, many of them directed towards the tumor suppressor p53, which coordinates the DNA damage respons

241 h and survival when the upstream Hippo tumor suppressor pathway is silenced, but efforts to pharmacol

242 hereby promoting activity of the Hippo tumor suppressor pathway.

243 Alternative tumour suppressor pathways need to be explored to treat p53- de

244 rvival of GBM stem cells by repressing tumor suppressor pathways.

245 hers do so by subverting senescence or tumor-suppressor pathways.

246 hange factor, and are regulated by the tumor-suppressor protein APC.

247 he presence of the RAD52 protein, the tumour suppressor protein BRCA2 acts as the predominant mediato

248 shown to interact with p3, an RNA-silencing suppressor protein encoded by Rice stripe virus (RSV), a

249 The p53 tumor suppressor protein is a potent activator of proliferativ

250 The adenomatous polyposis coli (APC) tumor suppressor protein is associated with the regulation of

251 th the recognition motif of either the tumor suppressor protein p53 or the oncogenic transcription fa

252 SH3 domain-containing protein 1) is a tumor suppressor protein that has roles in key cellular proces

253 ARCB1 has also been recognized to be a tumor suppressor protein which controls many tumorigenic event

254 E-cadherin is a tumor suppressor protein, and the loss of its expression in as

255 onsible for the nuclear export of many tumor-suppressor proteins and viral ribonucleoproteins.

256 high prevalence of pDGVs that truncate tumor suppressor proteins.

257 Tumor suppressor PTEN (phosphatase and tensin homologue delete

258 Quantification of the tumor suppressor PTEN in Colo-205 cells by immuno-MRM and immu

259 While the loss of the tumor suppressor, PTEN (phosphatase and tensin homolog), is we

260 HPV E7 binds the putative tumor suppressor PTPN14 and targets it for degradation using t

261 Insights into the role of the tumor suppressor pVHL in oxygen sensing motivated the testing

262 r induced by germline mutations in the tumor suppressors RB1 or DICER1.

263 Given the role of TGFbeta1 as a tumor suppressor, reduced epithelial TGFbeta1 activity and enh

264 ustain proliferative signaling, evade growth suppressors, resist cell death, promote replicative immo

265 osis regulators such as BCl-xL and the tumor suppressor retinoblastoma-associated protein 1 (RB1).

266 cancer suggesting a haploinsufficient tumor suppressor role for BAP1.

267 icle, Ramos et al. demonstrate a novel tumor-suppressor role of the circadian transcription factor BM

268 d to be frequently deleted, implying a tumor-suppressor role.

269 oncogenic signaling, we conducted a genetic suppressor screen in Drosophila melanogaster.

270 WTH INHIBITION RELIEVED 1 (GIR1) gene from a suppressor screen.

271 Here we use genome-wide CRISPR-Cas9 suppressor screens to identify the oxidative organelles

272 ption factor IRF-1, a well-established tumor suppressor, selectively attenuates MHV68-driven germinal

273 r of genes are bona fide oncogenes and tumor suppressors such as Ras, Myc, beta-catenin, p53, and APC

274 a functional link between oncomiR-31, tumor suppressor target EGLN3, and up-regulated NF-kappaB-cont

275 Retinoblastoma protein (Rb) is a tumor suppressor that binds and represses E2F transcription fa

276 PTEN is a frequently mutated tumor suppressor that has been linked to the PTEN hamartoma tu

277 e findings reveal that KLF3 is a fundamental suppressor that operates as a feedback inhibitor of RELA

278 Thus, DDX3X is a medulloblastoma tumor suppressor that regulates hindbrain development and rest

279 , FOXO proteins are context-dependent tumour suppressors that are frequently inactivated in human can

280 e harboring mutations in oncogenes and tumor suppressors that promote cancer growth, T-cell acute lym

281 aining high levels of transcription of tumor suppressors that promote cell death.

282 ere, we report the identification of genetic suppressors that result in anthocyanin accumulation in t

283 Unlike most tumor suppressors, they are rarely mutated/deleted, but rather

284 major genes, most commonly the dominant awn suppressor Tipped1 (B1).

285 tissue may explain AMPK switching from tumor suppressor to activator during tumor evolution.

286 The switch of p53 from tumor suppressor to oncogene is location-dependent and is impa

287 variants has been used to isolate lethality suppressors to assess important residues for GreA functi

288 ng wave, but several studies using far-basal suppressor tones claimed that SFOAE components originate

289 d kinase-dead DNA-PKcs and lacked the tumour suppressor TP53 developed myeloid disease, whereas all o

290 Specific deletion of the tumor suppressor TRAF3 from B lymphocytes in mice leads to the

291 ely regulates the gene expression of the AKT suppressor, TRIB3, through the CHOP pathway, which is a

292 pH-dependent proteins, including the mTORC1 suppressor Tsc2 and the longevity regulator Sirt1.

293 ate for the first time that p190A is a tumor suppressor using a xenograft mouse model with carcinoma

294 oprotein Mdm2 can bind directly to the tumor suppressor VHL, and conjugate nedd8 to VHL within a regi

295 n VHL, which encodes von Hippel-Lindau tumor suppressor (VHL), are associated with divergent diseases

296 To identify candidate tumor suppressors we applied CRISPR/Cas9 gene inactivation scr

297 the hypothesis that BC200 is a translational suppressor, we overexpressed BC200 by transfection of in

298 To investigate BCOR as a putative tumor suppressor, we used a genetically engineered mouse model

299 p16(INK4a) (CDKN2A) is a central tumor suppressor, which induces cell-cycle arrest and senescen

300 D1-mediated stress response as a novel tumor suppressor whose loss defines a RAS mutant tumor subset