ライフサイエンスコーパス: surfactant protein A

1 following exposure to surfactant lipids and surfactant protein A.

2 l infection, and as the SP-R210 receptor for surfactant protein A.

3 ells differentiate and exhibit expression of surfactant protein A, a constituent of the surfactant la

4 CARDS TX binds to human surfactant protein A and annexin A2 on airway epithelial

5 on of vascular endothelial growth factor and surfactant protein A and B, but this effect was countera

6 cs were analyzed using a combination of anti-surfactant protein A and BrdU immunohistochemistry and c

7 es even though several rare proteinopathies, surfactant protein A and C deficiencies, cause severe pu

8 was no increase in plasma concentrations of surfactant protein A and Clara cell protein.

9 es specific to the pulmonary epithelium, the surfactant protein A and Clara cell secretory protein ge

10 e role in production of parturition signals, surfactant protein A and platelet-activating factor, by

11 By dissecting the sequence derived from Surfactant Protein A and synthesizing short collagen-lik

12 type II pneumocyte lineage markers MUC1 and surfactant protein-A and the Clara cell lineage marker C

13 ein (endothelial permeability) and preserved surfactant proteins A and B concentrations as compared w

14 and by enzyme-linked immunosorbent assay for surfactant proteins A and B.

15 Surfactant proteins A and D (SP-A and -D) play a role in

16 Surfactant proteins A and D (SP-A and SP-D) are believed

17 Surfactant proteins A and D (SP-A and SP-D) are collecti

18 Surfactant proteins A and D (SP-A and SP-D) are lung col

19 vels of expression of mRNA for antimicrobial surfactant proteins A and D and sheep beta-defensin 1 we

20 r acute lung injury, lower concentrations of surfactant proteins A and D in the pulmonary edema fluid

21 The concentrations of surfactant proteins A and D were greater in both uninfec

22 The concentrations of surfactant proteins A and D were measured in pulmonary e

23 Surfactant proteins-A and -B and phospholipid in broncho

24 Surfactant proteins-A and -D, lactate dehydrogenase and

25 ines (e.g., transforming growth factor-beta, surfactant protein A, and angiotensin II) and a specific

26 hromatography with noncovalently immobilized surfactant protein A, and was purified from rat lung by

27 llagen-like peptides, using defense collagen Surfactant Protein A as a model.

28 Although surfactant protein A, B, and C content and surfactant pr

29 explants, immunostaining of lung tissue for surfactant protein A, B, and C, and electron microscopic

30 The levels of the other surfactant proteins (A, B, D) in alveolar lavage were co

31 hosphatidylcholine expanded 54-fold, and the surfactant proteins A, B, and C expanded 144-, 4-, and 1

32 itative lipidomic analysis of lipids and the surfactant proteins A, B, and C in lavage fluids from pa

33 uding lamellar body formation, expression of surfactant proteins A, B, and C, alpha-1-antitrypsin, an

34 Plasma surfactant protein A, but not surfactant protein D, was

35 eolar wall thickness, cell infiltration, and surfactant protein A concentration in bronchoalveolar la

36 2 +/- 2 n/field; p < 0.0001), and normalized surfactant protein A concentration was higher with flow-

37 uid surfactant protein D and elevated plasma surfactant protein A concentrations at the onset of acut

38 B. dermatitidis without or with normal BALF, surfactant protein A-deficient (SP-A-/-) or surfactant p

39 Subsequently, surfactant lipids and/or surfactant protein A enhance CD36 transcript and protein

40 by normal thyroid transcription factor 1 and surfactant protein A gene expression.

41 interactions between M. pneumoniae and human surfactant protein-A (hSP-A).

42 Enrichment of surfactant protein-A in the lung and surfactant of the m

43 Rat pulmonary surfactant protein A is an oligomer of 18 polypeptide ch

44 We have reported that surfactant protein A kills some Gram-negative organisms

45 n = 8), whereas incubation of bacteria with surfactant protein A leads to significantly increased ad

46 Surfactant protein A mRNA was reduced and, SP-A protein

47 onary surfactant isolated from gene-targeted surfactant protein A null mice (SP-A(-/-)) is deficient

48 Mannose binding lectin and lung surfactant protein A, other ligands of C1qR(P), also enh

49 neumonia and viral pneumonitis had decreased surfactant protein A/protein concentration (p < .001).

50 sphingomyelin ratio (r2 = .11, p < .001) and surfactant protein A/protein concentration (r2 = .03, p

51 The lecithin/sphingomyelin ratios and surfactant protein A/protein concentration were signific

52 o M. tuberculosis and indicate that SP-D and surfactant protein A serve different roles in the innate

53 ar macrophages (AM) from female mice lacking surfactant protein A (SP-A knockouts; KO) after "rescue"

54 munosuppressed Swiss Black mice deficient in surfactant protein A (SP-A(-/-)) and wild-type control m

55 In the lungs, surfactant protein A (SP-A) and SP-D contribute to immun

56 binding capability of surfactant-associated surfactant protein A (SP-A) and surfactant protein D (SP

57 Surfactant protein A (SP-A) and surfactant protein D (SP

58 Mice lacking surfactant protein A (SP-A) are susceptible to bacterial

59 The identification of surfactant protein A (SP-A) as an important innate immun

60 Our previous studies suggest that surfactant protein A (SP-A) can act as a ligand in the a

61 The host antimicrobial agent surfactant protein A (SP-A) effectively reduced ciliary

62 A single gene for rat surfactant protein A (SP-A) encodes two isoforms that ar

63 In the lung, surfactant protein A (SP-A) enhanced interleukin-4 (IL-4

64 Surfactant protein A (SP-A) enhances phagocytosis of Pse

65 Expression of the rabbit pulmonary surfactant protein A (SP-A) gene is lung-specific, occur

66 The surfactant protein A (SP-A) gene was disrupted by homolo

67 nserted in the protein-coding region for the surfactant protein A (SP-A) gene, which is highly expres

68 , tandem mutagenesis of Glu195 and Arg197 of surfactant protein A (SP-A) has implicated both residues

69 We previously reported that mice lacking surfactant protein A (SP-A) have increased airway hyperr

70 To determine the role of surfactant protein A (SP-A) in host defense, the murine

71 The current study investigated the role of surfactant protein A (SP-A) in opsonization and clearanc

72 hypothesize a central role for the collectin surfactant protein A (SP-A) in regulating the developmen

73 onal importance of the N-terminal domains of surfactant protein A (SP-A) including the N-terminal seg

74 onization of F. novicida with lung collectin surfactant protein A (SP-A) increased bacterial associat

75 Previous studies reported that surfactant protein A (SP-A) inhibits lymphocyte prolifer

76 Surfactant protein A (SP-A) is a C-type lectin found pri

77 Surfactant protein A (SP-A) is a hydrophilic glycoprotei

78 Surfactant protein A (SP-A) is a member of the collectin

79 Surfactant protein A (SP-A) is an abundant protein in pu

80 Surfactant Protein A (SP-A) is an abundant, multifunctio

81 Surfactant protein A (SP-A) is an immune modulator that

82 Surfactant protein A (SP-A) is an important mediator of

83 Surfactant protein A (SP-A) is an innate immune molecule

84 The carbohydrate recognition domain (CRD) of surfactant protein A (SP-A) is critical for the modulati

85 Surfactant protein A (SP-A) is important for immune defe

86 Pulmonary surfactant protein A (SP-A) is involved in innate immuni

87 While surfactant protein A (SP-A) is known to regulate TLR4 in

88 Surfactant protein A (SP-A) is selectively synthesized i

89 Surfactant protein A (SP-A) is the major protein compone

90 Surfactant protein A (SP-A) is well-known for its protec

91 The human surfactant protein A (SP-A) locus consists of two functi

92 We have previously shown that surfactant protein A (SP-A) mediates in vitro killing of

93 Surfactant protein A (SP-A) modulates host responses to

94 We tested the effects of surfactant protein A (SP-A) on inflammation and surfacta

95 Surfactant protein A (SP-A) plays a critical role in the

96 Pulmonary surfactant protein A (SP-A) plays a key role in innate l

97 Surfactant protein A (SP-A) plays a role in lung innate

98 Lung surfactant protein A (SP-A) plays an important function

99 Surfactant protein A (SP-A) plays an important role in t

100 Mass spectrometric characterization of the surfactant protein A (SP-A) receptor 210 (SP-R210) led t

101 rred through a mechanism involving increased surfactant protein A (SP-A) receptor density.

102 report we have characterized the binding of surfactant protein A (SP-A) to bone marrow-derived macro

103 st to immobilized human fibronectin (FN) and surfactant protein A (SP-A) under this condition.

104 Nitrated pulmonary surfactant protein A (SP-A) was also detected in the ede

105 We hypothesized that the expression of surfactant protein A (SP-A) would be altered in developi

106 Surfactant protein A (SP-A), a C-type lectin, plays an i

107 Surfactant protein A (SP-A), a major component of lung s

108 Surfactant protein A (SP-A), a major component of lung s

109 Pulmonary surfactant protein A (SP-A), a member of the collectin f

110 Surfactant protein A (SP-A), a member of the collectin f

111 Surfactant protein A (SP-A), a pulmonary member of the c

112 Pulmonary surfactant protein A (SP-A), an alveolar glycoprotein co

113 The biological functions of rat surfactant protein A (SP-A), an oligomer composed of 18

114 KGF is known to stimulate the expression of surfactant protein A (SP-A), an oxidant-sensitive T cell

115 The lung collectin, surfactant protein A (SP-A), has emerged as an important

116 Surfactant protein A (SP-A), one of four proteins associ

117 Surfactant protein A (SP-A), the most abundant pulmonary

118 retion of the major lung surfactant protein, surfactant protein A (SP-A), was first detected in amnio

119 ctin family of proteins, including pulmonary surfactant protein A (SP-A), we hypothesized that SP-A m

120 We observed that surfactant protein A (SP-A)-deficient mice have impaired

121 stance to antibacterial effects of pulmonary surfactant protein A (SP-A).

122 al cells (AEC) in the presence or absence of surfactant protein A (SP-A).

123 The PLA(2) activity is inhibited by surfactant protein A (SP-A).

124 roteins B and C (SP-B/C); with SP-B/C and 5% surfactant protein A (SP-A); and with SP-B/C, SP-A, and

125 ctivators 1 and 2 (SRC-1 and SRC-2) regulate surfactant protein-A (SP-A) and platelet-activating fact

126 L-1alpha caused a dose-dependent increase in surfactant protein-A (SP-A) and SP-B mRNAs (maximally, f

127 Previous reports demonstrate that surfactant protein-A (SP-A) binds live M. pneumoniae and

128 for measurements of the alveolar Sat-PC and surfactant protein-A (SP-A) concentrations.

129 Surfactant protein-A (SP-A) gene expression is developme

130 Surfactant protein-A (SP-A) is an important antimicrobia

131 Surfactant protein-A (SP-A) is an important mediator of

132 It has been suggested that surfactant protein-A (SP-A) protects surfactant activity

133 One component of this defense mechanism, surfactant protein-A (SP-A), exerts multifunctional role

134 eptor (VDR); soluble C-type lectins, such as surfactant protein-A (SP-A), SP-D, and mannose-binding l

135 Surfactant protein-A (SP-A), which is secreted by fetal

136 member of this protein family in particular, surfactant protein-A (SP-A).

137 mniotic fluid (AF) macrophages, activated by surfactant protein-A (SP-A).

138 Surfactant proteins A (SP-A) and D (SP-D) are important

139 Surfactant proteins A (SP-A) and D (SP-D) are members of

140 Surfactant proteins A (SP-A) and D (SP-D) are thought to

141 We now report that the hydrophilic surfactant proteins A (SP-A) and D (SP-D) directly prote

142 ophil elastase (NE) dependent degradation of surfactant proteins A (SP-A) and D (SP-D) in lungs of mi

143 Surfactant proteins A (SP-A) and D (SP-D) play an import

144 e N-terminal domains of the lung collectins, surfactant proteins A (SP-A) and D (SP-D), are critical

145 The pulmonary collectins, surfactant proteins A (SP-A) and D (SP-D), have been rep

146 The pulmonary collectins--surfactant proteins A (SP-A) and D (SP-D)--play importan

147 crobial actions of the pulmonary collectins, surfactant proteins A (SP-A) and D (SP-D).

148 To determine the role of surfactant protein-A(SP-A) in antiviral host defense, mi

149 mannose-binding lectin (MBL), and pulmonary surfactant protein A (SPA) are structurally similar mole

150 mannose-binding lectin (MBL), and pulmonary surfactant protein A (SPA) interact with human monocytes

151 Surfactant protein A (SPA) regulates macrophage function

152 Surfactant protein A (SPA), a lung-specific collectin, s

153 , plasminogen activator inhibitor-1 (PAI-1), surfactant protein-A, surfactant protein-D, and intracel

154 ry edema fluid surfactant protein D, but not surfactant protein A, was lower in patients with worse o

155 acheal aspirate surfactant phospholipids and surfactant protein A were noted in children with bacteri