ライフサイエンスコーパス: surmount

1 hat other scalable approaches have failed to surmount.

2 xt and the resulting challenges that must be surmounted.

3 nd provide suggestions about how they may be surmounted.

4 ll first require significant obstacles to be surmounted.

5 een hardness and toughness may eventually be surmounted.

6 In SURMOUNT-1 (N=2539) and SURMOUNT-2 (N=938), the median (

7 confidence interval [CI], -14.7 to -1.6) for SURMOUNT-1 and -31.1% (95% CI, -40.9 to -19.7) for SURMO

8 eek 72 of -42.3% (95% CI, -60.8 to -15.0) in SURMOUNT-1 and -55.2% (95% CI, -68.5 to -36.4) in SURMOU

9 In this post hoc analysis of the SURMOUNT-1 and SURMOUNT-2 trials, we assessed the associ

10 The magnitude of weight reduction in the SURMOUNT-1 trial of the dual GLP-1 and GIP receptor agon

11 he clinical response of men and women in the SURMOUNT-1 trial who carried pathogenic mutations in the

12 In an earlier analysis of the SURMOUNT-1 trial, tirzepatide was shown to provide subst

13 tabolic risk factors for participants in the SURMOUNT-1 trial.

14 In SURMOUNT-1, participants with overweight or obesity with

15 In SURMOUNT-1, tirzepatide was associated with increased eG

16 In SURMOUNT-1, tirzepatide-associated improvements in cardi

17 SURMOUNT-1: NCT04184622; SURMOUNT-2: NCT04657003.

18 In SURMOUNT-1 (N=2539) and SURMOUNT-2 (N=938), the median (25th-75th percentile) ba

19 In SURMOUNT-2 at week 72, increases in both tirzepatide and

20 this post hoc analysis of the SURMOUNT-1 and SURMOUNT-2 trials, we assessed the association of tirzep

21 In SURMOUNT-2, participants with type 2 diabetes were rando

22 UNT-1 and -55.2% (95% CI, -68.5 to -36.4) in SURMOUNT-2, respectively.

23 NT-1 and -31.1% (95% CI, -40.9 to -19.7) for SURMOUNT-2.

24 SURMOUNT-1: NCT04184622; SURMOUNT-2: NCT04657003.

25 on, (Ge(4)Bi(14))(4-), and they equal (2) or surmount (3) that reported for the anion and the cations

26 PARTICIPANTS: This post hoc analysis of the SURMOUNT-4 trial included tirzepatide-treated participan

27 In this post hoc analysis of the SURMOUNT-4 trial, among participants with obesity who ac

28 In the SURMOUNT-4 trial, most adults with obesity who had tirze

29 ntrast, cyclobutylidenecarbene only needs to surmount a barrier of 1.6 kcal mol(-1) to rearrange into

30 kcal/mol whereas the 1,2-methyl shift has to surmount a much larger barrier of 11.9 kcal/mol.

31 ossible, a biological catalyst would have to surmount a significantly higher activation barrier to fa

32 The gain in energy is used to surmount a small energy barrier on the pathway from the

33 ts into the primary response of C. jejuni to surmount a sudden temperature upshift, allowing the bact

34 packed small squamous epithelial cells that surmounted a highly regimented basal layer with a picket

35 a process that would be expected to involve surmounting a considerable energy barrier.

36 the high-fidelity operation to be possible, surmounting a main obstacle in the pathway to scalable a

37 ergo fragmentation to the lactone product by surmounting a second energy barrier of about 7 kcal/mol.

38 til recently, most of the strategies used to surmount ABC-transporter-mediated MDR have had limited s

39 ible peptidyl transfer and GTP hydrolysis to surmount activation barriers to large-scale conformation

40 larly biomolecules) are caught in the act of surmounting activation barriers.

41 In order to surmount aforementioned problems of LSTM, we adopt the r

42 oach for high-temperature nanophotonics that surmounts all of these difficulties.

43 emical reactions, reactant molecules need to surmount an energy barrier to allow their transformation

44 Many pathogens must surmount an epithelial cell barrier in order to establis

45 ate for the unguided residue-level search to surmount an initial kinetic barrier rather than for the

46 In these experiments, unfolding requires surmounting an energy barrier that separates the native

47 ce coverage appear to be a crucial factor in surmounting an ongoing but treatable chronic disease.

48 riers to human xenotransplantation have been surmounted and identifies where new knowledge is needed

49 llenges and limitations which will be likely surmounted as our understanding of plant volatile networ

50 into two TCNE(-) anions that can be quickly surmounted at room temperature but not at 77 K.

51 ly used as pain relievers in the clinic, can surmount axon growth restrictions from myelin and proteo

52 thod, transition path sampling is capable of surmounting barriers in path phase space and focuses sim

53 a viruses into the human population requires surmounting barriers to cross-species infection.

54 There is growing interest in identifying and surmounting barriers to employment for people with schiz

55 design criteria and key hurdles that must be surmounted before clinical implementation.

56 ntial hurdles have also surfaced and must be surmounted before therapeutic RNAi applications can beco

57 g them from unrestricted pluripotency can be surmounted by a single reprogramming factor.

58 Here we show that such resistance can be surmounted by an injectable depot of thermally responsiv

59 ive FA cells, this restriction was partially surmounted by antagonizing the DNA-dependent protein kin

60 urthermore, the effects of SCH23390 could be surmounted by co-administration of a sub-threshold dose

61 t the poor immunogenicity of peptides can be surmounted by delivery vehicles that overcome the system

62 receptor antagonist whose inhibition can be surmounted by glycine.

63 ion was voltage-independent and could not be surmounted by increasing concentrations of either coagon

64 adenosine, and whether the antagonism can be surmounted by increasing the adenosine dose.

65 nce, and enzalutamide drug resistance can be surmounted by indomethacin a potent inhibitor of AKR1C3.

66 The obstacle can be surmounted by newly developed theoretical methods of car

67 ion polymer solar cells, this problem can be surmounted by solution-based incorporation of fulleropyr

68 This difficulty could be surmounted by the use of N-substituted pyrazoles.

69 This long-standing challenge was surmounted by training a deep convolutional generative a

70 anwhile, screening pro-drug variants enabled surmounting cell permeability limitations imposed by aci

71 e we introduce an interferometric technique, surmounting challenges of bulk motion to apply it in awa

72 Understanding how pathogens surmount control strategies and cope with new climates i

73 ard a portable OP quantification method that surmounts conventional limitations involving sensitivity

74 ble for a broad range of applications, which surmounts current limitations of high-throughput fabrica

75 Moreover, the well-known paradox is surmounted, delivering record-high Na utilization (e.g.,

76 in the harnessing of unconventional NCIs to surmount difficult selectivity challenges in glycosylati

77 Reaching this goal requires surmounting diverse challenges in nanofabrication and at

78 cles (sEVs) possess significant potential in surmounting drug resistance as they can effectively evad

79 xpression of KRAS due to rare codons must be surmounted during drug resistance.

80 Provided potential barriers to success are surmounted, each achieves high efficacy at reducing tran

81 Such process surmounts enormous specificity, efficiency and celerity

82 ce and temperature, a challenge that must be surmounted every time a cell divides.

83 We highlight surmounting evidence suggesting that some T cell clones

84 while helpful in bacterial clearance and in surmounting excessive inflammatory tissue damage, could

85 cells and induced pluripotent stem cells, to surmount existing challenges.

86 ight-enabled aza Paterno-Buchi reaction that surmounts existing limitations and represents a mild sol

87 re still poorly understood and processes for surmounting fitness valleys remain controversial.

88 trial vertebrates, so the main barrier to be surmounted for dispersal between hemispheres was likely

89 teps in the aggregation pathway that must be surmounted for tau filaments to form in disease.

90 ted the existing limitations that need to be surmounted for the effective implementation of MIP-based

91 coenzyme Q presents a paradigm for how cells surmount hydrophobic barriers in lipid biology.

92 aps more natural responses scientists use to surmount impediments to research.

93 ranslational obstacle that is challenging to surmount in neurons, where primary tissue availability i

94 e of the challenges that CAR T cells have to surmount in the solid tumor microenvironment and new app

95 lly demanding challenge that must be met and surmounted in a short time if the patient is to survive.

96 These challenges have been surmounted in limited initiatives and now must be transl

97 nhibition may present a barrier that must be surmounted in order to achieve an increase in M1 excitab

98 g because of the energy barrier that must be surmounted in order to bring together and fuse the two e

99 nt of the energetic barriers that need to be surmounted in the motion, and as a by-product results in

100 fically address the problems that need to be surmounted in the push toward a therapeutic application

101 decade to develop new antimalarial drugs to surmount increasing resistance to common therapies, chal

102 gene expression in the differentiated cells, surmounting issues of transgene silencing.

103 The synthetic route surmounts issues of individual step stereoselectivity an

104 -ALS) algorithm in confocal Raman imaging to surmount its instrumental limits and to characterize che

105 nt can provide an innovative solution to the surmounting levels of e-waste.

106 odels; simulations of the latter then easily surmount long equilibration time scales and enable rigor

107 mbly in living cells offers the potential of surmounting many of the limitations inherent in other ap

108 dless of its activating mutation, compound 3 surmounts many of the common limitations of available Ra

109 Here, to explore cellular strategies for surmounting mitochondrial stress, we conducted a series

110 ffective blockade of CGRP signaling required surmounting multiple challenging hurdles, including defe

111 t maintain nitric oxide (NO) homeostasis and surmount nitric oxide stress from host immune responses

112 ta support the notion that ImmSig assists in surmounting normal barriers related to oxidative and rep

113 have at least one PNS on its faculty and to surmount obstacles that currently impede the incorporati

114 e do-not-resuscitate policy is essential for surmounting obstacles to a well functioning perioperativ

115 Malhotra A, Grunstein RR, Fietze I, et al; SURMOUNT-OSA Investigators.

116 Herein, we review recent efforts to surmount pathway engineering challenges and to rationall

117 al design and execution issues which, unless surmounted, predictably generate a distorted image of th

118 tial electron transfer in catalytic sites to surmount radical transition states without involving the

119 more visible public and political support to surmount remaining hurdles.

120 ce is high but teams have a critical role in surmounting residual vaccine resistance.

121 aditional therapeutics, present a pathway to surmount resistance within tumors that no longer respond

122 l for augmenting immunotherapy responses and surmounting resistance to existing cancer therapies.

123 as an early targeting strategy to assist in surmounting resistance to pro apoptotic therapies.

124 Surmounting strong inhibition by CSPG-rich scar is an im

125 As barriers to xenotransplantation are surmounted, such as suppression of hyperacute rejection

126 NDSN scholars surmount systemic funding barriers by building relations

127 h atoms in the anions in 2 and 3 furthermore surmount that of the Bi-richest binary main-group anion,

128 en (LFA)-1 with costimulatory blockade could surmount the barrier posed by heterologous immunity in a

129 nase, both cofactor-independent enzymes that surmount the barriers to direct substrate/O2 reactivity

130 To surmount the barriers to empirical studies of the minusc

131 Creative and effective strategies that surmount the barriers to provision of mental healthcare

132 disorders, novel approaches are required to surmount the blood-brain barrier (BBB).

133 enzymes that assemble these macrocycles must surmount the challenge of installing a single specific s

134 l-world evidence have already taken steps to surmount the challenges associated with research into lo

135 uired to address these knowledge gaps and to surmount the challenges faced in the clinical applicatio

136 ntegrating TPD into delivery platforms could surmount the challenges of in vivo applications of TPD s

137 Here, we surmount the conventional hurdles of activity measuremen

138 clinical practice, our novel algorithm could surmount the current limitations of manual 2D measuremen

139 romiscuity of chemokines and CCR was able to surmount the deletion of CCR2, still resulting in full e

140 ed (IR) and visible (VIS) spectrum images to surmount the difficulties posed by low-light settings.

141 a large selective advantage to the vector to surmount the effects of a moderate dissociation rate and

142 ed fibroblasts into induced TSCs (iTSCs) and surmount the epigenetic barrier separating somatic from

143 s exploit DAF-mediated signaling pathways to surmount the epithelial barrier.

144 al priority for ECD, proponents will need to surmount the framing and governance challenges and lever

145 Neuropsychiatry has yet to surmount the fundamental challenge of mapping behavioral

146 To surmount the inherent limitations and fully harness the

147 an opportunity to study molecules that might surmount the intrinsic limitations they share with mamma

148 How these enzymes surmount the kinetic barrier to reactions between single

149 ense functional imaging of brain activity to surmount the limitations of present methodologies.

150 Our analysis attempts to surmount the limitations of prior grant studies by exami

151 a novel computational framework designed to surmount the limits of conventional simulation methods.

152 This innovative approach aims to surmount the long-standing barrier, facilitating the syn

153 at essentially has an unstructured region to surmount the noisy proximal region, a homomeric polyprot

154 97, while unfolding a protein substrate, can surmount the obstacle of a DNA crosslink site in the sub

155 Finally, we surmount the perennial limitation of rigid interconnects

156 COT sequences are designed to surmount the potential pitfalls stemming from sampling b

157 earch algorithm was applied in an attempt to surmount the problem of genetic heterogeneity.

158 Low-coverage sequencing approaches surmount the problems induced by the ascertainment of co

159 h allowed for sufficient collision energy to surmount the reaction barrier.

160 orrhiza (AM) and nitrogen-fixing bacteria to surmount the scarcity of soil nutrients and tap into atm

161 to the high levels of activation required to surmount the threshold barriers.

162 ur findings uncover specific mechanisms that surmount the unique challenges of X-Y recombination.

163 These carriers must be able to surmount the various intracellular and extracellular bar

164 equilibrium after a subset of reactants have surmounted the barrier to become products.

165 ing technologies and use of gene sets likely surmounted the limitations of previously inconsistent HD

166 on is due to the supplementary RF-activation surmounting the activation barrier energy of the entranc

167 tion of reactants is the main contributor to surmounting the barrier, since all transition states (TS

168 Surmounting the barriers to progression for female surge

169 t reprogramming mouse fibroblasts into TSCs, surmounting the first lineage barrier established in dev

170 Surmounting the heart regeneration barrier would transfo

171 e (QR) codes, and Bluetooth technologies, by surmounting the limitations encountered by these systems

172 s enable mesotrypsin-BPTI complex formation, surmounting the predicted steric clash introduced by Arg

173 ed new therapeutic targets for chronic pain, surmounting the redundancy of the pain signaling pathway

174 nces the possibility of nonthermal electrons surmounting the Schottky barrier for successful injectio

175 Integrated strategies are needed for surmounting the stringent experimental requirements of n

176 Evidence suggests that compression surmounts the boundary of elasticity via intermolecular

177 The routine use of MBR capably surmounts the difficulties brought about by the anatomic

178 midazopyridines" with distinct amines, which surmounts the long-standing requirement for a superfluou

179 performing carbohydrate epimerizations that surmounts the main disadvantages of current enzymatic an

180 Successful trisomy silencing in vitro also surmounts the major first step towards potential develop

181 Ability of peptide-specific IgG4 to surmount their IgE counterpart seems to be important in

182 itial pairing of Cys(A20) and Cys(B19), thus surmounting their wide separation in sequence.

183 and bias, along with potential directions to surmount them.

184 ficant obstacles and suggested approaches to surmounting them are elaborated.

185 nts and implementing practical approaches to surmounting them is a rational approach to advancing hea

186 trials and propose potential strategies for surmounting them.

187 nd 10.4 kcal mol(-1) are much too high to be surmounted thermally under cryogenic conditions.

188 a developmental pipeline that may be able to surmount these challenges and bring novel biomarker solu

189 we describe ongoing efforts in the field to surmount these challenges and precisely characterize psy

190 The use of an application ontology helps surmount these challenges by combining image data with i

191 To surmount these challenges, we created a first-in-class,

192 sively developed in the preclinical phase to surmount these challenges.

193 ticles and siRNA conjugates, are designed to surmount these challenges.

194 To surmount these difficulties, we used probability analysi

195 the efforts of the ant research community to surmount these hurdles and obtain novel mechanistic insi

196 scalable logic tiles for nanoprocessors that surmount these hurdles.

197 To surmount these impediments, we have adapted a costimulat

198 and speculating on the future strategies to surmount these impediments.

199 ial block-face electron microscopy (SBEM) to surmount these limitations and investigate the establish

200 To surmount these limitations, a paper-based biosensor was

201 To surmount these limitations, we have developed a silicon-

202 To surmount these limitations, we here present multi-eGO, a

203 To surmount these limitations, we introduce a two-step asse

204 emand alternative compounds that are able to surmount these limitations.

205 anotechnology offers innovative solutions to surmount these obstacles and amplify the potency of mRNA

206 Finding ways to surmount these obstacles will provide opportunity for im

207 ture's carbon capture machinery, can help us surmount these threats.

208 We surmounted these limitations by using saturating genomic

209 Only a few mucosal vaccines have surmounted these obstacles thus far.

210 This review focuses on identifying and surmounting these barriers.

211 Surmounting these challenges will require the cooperatio

212 ies such as wearable sensors show promise in surmounting these limitations in that they measure heter

213 still developing and challenges remain to be surmounted, these recent advances nevertheless hold trem

214 s enable the IAV RNA polymerase (FluPolA) to surmount this barrier.

215 Scalable models of care may help surmount this barrier.

216 To surmount this challenge, we extend traction force micros

217 main (S4) of voltage-gated ion channels must surmount this energy barrier to initiate channel activat

218 To surmount this inherent limitation, we developed an appro

219 Here we surmount this issue and report that spike shape and neur

220 d by leukocyte contamination; an approach to surmount this problem is single cell analysis.

221 To try and surmount this problem we have constructed a retroviral p

222 To surmount this problem, we conjugated a heptamer of argin

223 To surmount this problem, we developed a sequence-based mac

224 In an effort to surmount this problem, we have generated gene delivery v

225 To surmount this problem, we produced perceptual priming (i

226 To surmount this shortcoming, we devised a method for mucos

227 Attempts to surmount this therapeutic challenge are hindered by a po

228 To surmount this, a comprehensive deep learning pipeline is

229 psid engineering is one possible approach to surmounting this challenge but necessitates an understan

230 In AMKL, surmounting this differentiation blockade through restor

231 One potential approach to surmounting this impediment is to exploit MRI of magneti

232 by sequestering iron within haem, S. aureus surmounts this challenge by employing high-affinity haem

233 n a noncontractile state until term and then surmounts this state to enter labor.

234 s Ion-based Data Extraction Algorithm) which surmounts this void.

235 of the different obstacles that viruses must surmount to achieve entry; among virus particles attachi

236 t a solvent-dependent energy barrier must be surmounted to access the singlet-to-triplet crossing reg

237 cell development and what obstacles must be surmounted to bring hematopoietic cell therapies from hu

238 d the ethical, logistic, and medical hurdles surmounted to enable donation.

239 evant funding agencies to support efforts to surmount today's data barriers and facilitate analytical

240 RNA polymerase must surmount translocation barriers for continued transcript

241 ion route and selection of materials able to surmount transport barriers are important considerations

242 se of a repulsive interaction, which TRAPPII surmounts using the Trs120 subunit as a "lid" to enclose

243 s associated with multi-species tracking are surmounted, we envision a future where individual moveme

244 The first barrier is surmounted with the assistance of 2 conserved residues (

245 DESIGN, SETTING, AND PARTICIPANTS: The Surmounting Withdrawal to Initiate Fast Treatment with N

246 c acquisition mechanism used by Y. pestis to surmount zinc limitation during the infection of both th