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1 , 0.8% minor errors) using micafungin as the surrogate marker.
2 des and may eventually be considered as a T2 surrogate marker.
3 unohistochemistry could serve as a potential surrogate marker.
4 ng process in terms of histology and certain surrogate markers.
5 naling, suggesting the peptides may serve as surrogate markers.
6 ages, allowing potential definition of novel surrogate markers.
7 odel and compare its performance to existing surrogate markers.
8 d for future research that evaluates or uses surrogate markers.
9 e were seen for 1 of 23 participant-reported surrogate markers, 2 of 25 visual spatial tests, and 2 o
10 nd cytometric bead array, formed an in vitro surrogate marker and correlate of the in vivo host immun
11 cer undergoing radical resection is an early surrogate marker and correlate to oncologic outcomes.
13 ession of eIF3I in HCC is oncogenic and is a surrogate marker and therapeutic target for treatment wi
14 cle, we examine the challenges of evaluating surrogate markers and describe the framework proposed in
16 nsitivity troponin T (hs-TnT) can be used as surrogate markers and whether genetic variability in ger
20 We present case studies of 2 well-accepted surrogate markers [blood pressure within sodium intake a
21 nd monitored their fate by X-Gal staining, a surrogate marker coexpressed with the K-Ras(G12V) oncopr
25 a genome-wide level by using common promoter surrogate markers (e.g., histone modifications) and were
27 uced intrapatient variability of Tac Cmin, a surrogate marker for 24-hour drug exposure (AUC0-24), ha
28 d the accuracy of discharge destination as a surrogate marker for 6-month mobility impairment in acut
29 )F-FDG PET/MR enterography index as a hybrid surrogate marker for active ileocolonic inflammation in
30 phasizes the potential for DTC analysis as a surrogate marker for adjuvant treatment effect in breast
35 erebrospinal fluid (CSF) tau is an excellent surrogate marker for assessing neuropathological changes
41 ells expressing both a caspase-3 sensor as a surrogate marker for caspase-3 activation and Renilla lu
42 ctivation and Renilla luciferase (Rluc) as a surrogate marker for cell viability were established and
45 light chain (NF-L) could be a more practical surrogate marker for disease staging in amyotrophic late
47 tted from the emergency department acts as a surrogate marker for early aggressive care in the manage
48 y correlated with HER2 status, possibly as a surrogate marker for ER status and a predictor for tamox
49 bacterial clearance could serve as a timely surrogate marker for evaluating the appropriateness of a
50 1 collagen-targeted gadolinium-based probe (surrogate marker for extracellular matrix (ECM) remodeli
51 pecific gadolinium-based probe (0.2 mmol/kg, surrogate marker for extracellular matrix degradation).
58 n oxide-based probe (ferumoxytol, 4 mgFe/kg, surrogate marker for inflammatory activity) and an elast
59 ) remodeling) and an iron oxide-based probe (surrogate marker for inflammatory activity), in one imag
62 flow (RPF), and filtration fraction (FF) (a surrogate marker for intraglomerular pressure) were meas
66 s the importance of MRD-negative status as a surrogate marker for longer PFS in clinical studies to a
67 a clinical sign of intestinal failure and a surrogate marker for markedly increased risk of mortalit
70 nce relative to linear RNAs can be used as a surrogate marker for mRNA stability in the absence of tr
71 minant antiemetic used at GMH, was used as a surrogate marker for nausea in the initial GMH cohort; n
74 Since the catatonic syndrome is likely a surrogate marker for other executive function defects, w
75 recent metaanalysis could validate pCR as a surrogate marker for patient outcomes only in aggressive
77 on, these data implicate Pin1 as a potential surrogate marker for predicting outcome of ERalpha-posit
78 Peritransplant ALC is a novel and useful surrogate marker for prediction of HCV recurrence and pa
80 h using endogenously generated VOCs can be a surrogate marker for recognition of sputum inflammatory
83 study aimed to evaluate vWF-Ag as an adjunct surrogate marker for risk stratification on the waiting
84 eptomeningeal enhancement may prove a useful surrogate marker for such pathology, perhaps improving o
85 pressed higher levels of cell surface CD5, a surrogate marker for TCR avidity for self-pMHC, as compa
86 itude of muscle contractions, representing a surrogate marker for the characteristic loss of muscle s
87 ggest that [F-18]-AV-1451 holds promise as a surrogate marker for the detection of brain tau patholog
88 t the degree of hypointensity can serve as a surrogate marker for the efficacy of tumor vaccination.
92 olute lymphocyte count (ALC) is considered a surrogate marker for the level of immunosuppression and
93 an fluorescence intensity was not a suitable surrogate marker for the prediction of complement bindin
96 eperfusion treatment but rather represents a surrogate marker for the severity of risk and injury to
97 guidelines recommend trough monitoring as a surrogate marker for the target area under the curve ove
98 hinococcosis (AE) and has been proposed as a surrogate marker for therapeutic decisions on structured
99 ribosomal protein S6 (P-S6) was defined as a surrogate marker for TOR-dependent anabolic activity in
100 salpinx in women and mice has been used as a surrogate marker for tubal infertility, the medical rele
105 thrombosis, despite the lack of evidence of surrogate markers for atherosclerosis in primary APS.
106 and CRISP2 DMRs hold promise as novel blood surrogate markers for early risk stratification and CVD
107 O-a free radical gas-has been difficult, and surrogate markers for eNOS activation are widely utilize
108 binding MR contrast agent and may be used as surrogate markers for evaluating the healing response of
110 and interleukin-6 (IL-6) levels were used as surrogate markers for inflammation and were measured at
112 ereas serum levels of phytosterols represent surrogate markers for intestinal cholesterol absorption,
113 r arterial blood gas monitoring, noninvasive surrogate markers for lung disease severity are needed t
115 T KO mice, RhBG expression was not affected, surrogate markers for oxidative stress were strongly up-
116 retina is an attractive source of potential surrogate markers for paediatric cerebral malaria becaus
119 magnitude of EBVd were assessed as potential surrogate markers for the occurrence of late adverse eve
120 verity markers, which use SpO2, are adequate surrogate markers for those that use PaO2 in children wi
121 al progenitor cell (EPC) counts are proposed surrogate markers for vascular function and cardiovascul
122 r potential usefulness in the development of surrogate markers for vector delivery during the first w
124 lity may not be a feasible endpoint and many surrogate markers have been explored, ranging from pulmo
127 status of the optic nerve and will provide a surrogate marker in future remyelination clinical trials
128 lcitonin (PCT) has been shown to be a useful surrogate marker in identifying patients with various ba
129 At present, the suitability of CIMT as a surrogate marker in trials of cardiovascular therapies t
130 says and breath tests could become important surrogate markers in early bactericidal activity (EBA) s
133 The correlation of PD with ASVD outcomes and surrogate markers is discussed, as well as the correlati
134 ve model with the use of different vitamin D surrogate markers (latitude of residence, mean annual re
138 arms, ICR (compared with CR) seemed to be a surrogate marker of a greater burden of anatomical coron
143 noninvasive imaging technique that detects a surrogate marker of apoptosis may help characterize the
144 show increased concentrations of copeptin, a surrogate marker of arginine vasopressin (AVP), to be as
145 ter of >/=40 from month 13 to month 25) as a surrogate marker of asymptomatic infection in the vaccin
146 easing peptide (pro-GRP) was identified as a surrogate marker of Bcl-2 amplification and changes corr
147 or partially the IGFBP and vWC domains as a surrogate marker of CCN1 activity in PDR distinguishing
148 significantly correlated with 2-week Ki67, a surrogate marker of clinical outcome (r = -0.179; P = .0
149 onounced coronary artery calcification, as a surrogate marker of coronary atherosclerosis, does not u
151 ilure strongly reduce midazolam clearance, a surrogate marker of CYP3A-mediated drug metabolism, in c
153 rophy on serial MRI are frequently used as a surrogate marker of disease progression in Alzheimer's d
157 hosterol-to-cholesterol ratio (L:C ratio), a surrogate marker of endogenous cholesterol synthesis, se
159 endothelium-dependent vasodilation and is a surrogate marker of endothelial function and NO bioavail
160 a valid, reliable, repeatable, and specific surrogate marker of eosinophils and/or eosinophil degran
161 tion and fatty liver index (FLI; a validated surrogate marker of fatty liver), as well as the associa
162 alactomannan assay (GM), a non-culture-based surrogate marker of fungal infection, is widely used in
167 ft ventricular ejection fraction (LVEF) is a surrogate marker of heart failure (HF) status and associ
168 nsferase-to-platelet ratio index (APRI) as a surrogate marker of hepatic fibrosis to characterize liv
169 perioperative aspartate aminotransferase, a surrogate marker of hepatic ischemia reperfusion injury,
172 gher residual SYNTAX Score was shown to be a surrogate marker of increasing clinical comorbidity and
174 ole retinal thickness in the rat as a useful surrogate marker of inner and outer retinal changes.
175 elationship between body mass index (BMI), a surrogate marker of insulin resistance, and iron burden
177 Allergen-specific IgG, which served as a surrogate marker of maintaining protective IgG responses
178 DC) at low- and medium-b-value regimens as a surrogate marker of microcirculation, to study its corre
179 d antibody-in-lymphocyte supernatant (ALS, a surrogate marker of mucosal immune responses) from patie
182 elin-specific CD4 T cells expressing CD56, a surrogate marker of NK cells, were shown to be cytotoxic
183 P-43-related disease, and which is used as a surrogate marker of non-amyloid-beta protein aggregation
185 tracerebral haemorrhage, and may be a useful surrogate marker of ongoing ischaemic injury from small-
188 om arterial plasma to tissues) was used as a surrogate marker of perfusion to correct the binding pot
190 llular volume fraction (ECV), representing a surrogate marker of reactive interstitial fibrosis, and
192 n-binding contrast agent, gadofosveset, is a surrogate marker of rupture-prone atherosclerotic plaque
194 an indicator of diastolic dysfunction and a surrogate marker of significant left to right shunts.
195 ce is a crude explanatory variable that is a surrogate marker of socioeconomic status, education, and
197 -67, indicative of cell division, and CD5, a surrogate marker of TCR avidity, and produced the cytoki
198 t that early metabolic response can act as a surrogate marker of the benefit of antiangiogenic therap
199 Circulating CLA(+) T cells may be a reliable surrogate marker of the inflammatory events occurring in
200 ein-Barr virus (EBV) DNAemia (EBVd) may be a surrogate marker of the net state of immunosuppression a
202 ot only a signpost of cholestasis but also a surrogate marker of the severity of primary biliary cirr
205 f allergen immunotherapy and may be a useful surrogate marker of treatment efficacy in future studies
207 orrelation with PSA levels (P < 0.0001) as a surrogate marker of tumor burden, whereas SUVmax (P = 0.
208 colony-forming unit osteoblasts (CFU-Os), a surrogate marker of undifferentiated mesenchymal cells a
210 correlated with fetal copeptin production, a surrogate marker of vasopressin, and dependent on the ex
213 yer (RNFL) thickness have been proposed as a surrogate marker of vision but this technique is also li
215 were used to validate salivary VZV DNA as a surrogate marker of VZV reactivation and then to determi
216 to be associated with T1 relaxation times, a surrogate marker of water content, but not with GABAA re
218 3S/C33S) mice as determined from analyses of surrogate markers of active TGF-beta, such as P-Smad2, C
220 afor uptake is significantly associated with surrogate markers of atherosclerosis and is linked to th
221 tween serum micronutrient concentrations and surrogate markers of atherosclerosis in a cohort of HIV-
222 though quantified decoy cells are acceptable surrogate markers of BK viral replication with unexcepti
223 DED and ePiB, respectively) were compared as surrogate markers of brain perfusion, and the extent to
224 t on cIMT and little or no effect on several surrogate markers of cardiovascular disease in non-diabe
226 ation of atherogenic risk factors, including surrogate markers of carotid and coronary atherosclerosi
233 Therefore, Vbeta expansions can serve as surrogate markers of CTL clonality to assess clonal kine
234 ls from uninfected animals, but importantly, surrogate markers of cytotoxicity in infected macaques w
235 rocirculatory perfusion status, as direct or surrogate markers of disease, are therefore of uttermost
236 ected imprinted genes may therefore serve as surrogate markers of DNA methylation in cancer tissue.
240 ajor limitation of this study was the use of surrogate markers of frailty and comorbid conditions to
243 o-ethyl)-l-tyrosine ((18)F-FET) were used as surrogate markers of glucose utilization, proliferative
244 dothelial cell therapy showed mean levels of surrogate markers of hepatobiliary injury that were cons
248 l studies that assessed associations between surrogate markers of innate technical abilities in surgi
249 indications for empirical treatment based on surrogate markers of invasive candidiasis are warranted.
250 contact force, ablation duration, and these surrogate markers of lesion formation may allow us to de
254 s have tended to use biochemical and imaging surrogate markers of NAFLD, such as elevated gamma gluta
255 disease (sCJD) are based on the detection of surrogate markers of neuronal damage such as CSF 14-3-3,
256 cortex showed that JNK inhibition suppressed surrogate markers of neurovascular remodeling, including
257 Many proteins have been proposed to act as surrogate markers of organ damage, yet for many candidat
258 iopoietin-2 release correlated strongly with surrogate markers of organ dysfunction and disease sever
259 artially independent of insulin resistance), surrogate markers of oxidative stress and gut microbial
261 es of trials of aggressive statin therapy on surrogate markers of progression have shown no benefit f
262 e factor 6 (KLF6) as critical regulators and surrogate markers of prostatic tissue architectures, whi
263 transcriptome data may be useful in defining surrogate markers of protection and pathology, they shou
264 tive tuberculosis (aTB) may help to identify surrogate markers of protection, as LTBI subjects are mo
265 ighlight the limitations of current in vitro surrogate markers of protection, such as cell-based neut
266 to women of all ancestries; 2) intermediate surrogate markers of response to preventive measures; 3)
267 ly that these 2 structural parameters may be surrogate markers of retinal function in the early stage
271 ign of embolic protection devices focuses on surrogate markers of the clinical disease, primarily on
274 tigen (PCNA) and FANCD2 monoubiquitinations (surrogate markers of TLS and FA pathway activation, resp
275 (RNAi)-mediated suppression of ENOX1 impairs surrogate markers of tumor angiogenesis/vasculogenesis,
279 ondary adjuvant treatment and the subsequent surrogate marker potential of DTCs for outcome determina
280 en FSR, suggesting applications as direct or surrogate markers, respectively, of hepatic fibrogenesis
281 genes in the peripheral blood can be used as surrogate marker(s) for DOX-induced cardiotoxicity.
282 e of the improved CSF RT-QuIC is superior to surrogate marker tests for prion diseases such as 14-3-3
284 hosphoinositide cycle and has CNS effects on surrogate markers that may be relevant to the treatment
285 score which uses biopsy transcriptomics as a surrogate marker to accurately track disease severity.
286 erefore, MRD quantification might serve as a surrogate marker to assess treatment efficacy in randomi
287 high frequency oscillations can be used as a surrogate marker to distinguish the core seizure territo
288 erase chain reaction can be used as a timely surrogate marker to evaluate the appropriateness of anti
292 cCEST MRI signal can be used as a label-free surrogate marker to non-invasively assess mucin glycosyl
293 Anidulafungin can accurately serve as a surrogate marker to predict S and R of Candida to caspof
294 ressed the application of anidulafungin as a surrogate marker to predict the susceptibility of Candid
295 ues, we evaluated the use of micafungin as a surrogate marker to predict the susceptibility of Candid
296 t in childhood, there is a critical need for surrogate markers to best assess, predict, and treat the
297 or monitoring disease progression and act as surrogate markers to identify underlying disease process
298 ver-operating-characteristic curves for each surrogate marker were created and tested against each ot
300 r the identification of treatment-associated surrogate markers, which may be provided by neuroimaging