ライフサイエンスコーパス: survivin

1 oliferation and survival (e.g. cyclin D1 and survivin).

2 ified survivin peptide but cross-reactive to survivin.

3 ased the levels of the antiapoptotic protein survivin.

4 e of androgen and consequent upregulation of survivin.

5 oteins FLIP, Mcl-1, Bcl-2, cIAP1, cIAP2, and survivin.

6 of activated T cells, B-cell lymphoma 2, and Survivin.

7 ocytes did suppress proliferation and reduce survivin.

8 ion by controlling the cellular abundance of survivin.

9 of activated T cells, B-cell lymphoma 2, and Survivin.

10 r HuR, and the cell-cycle regulators p21 and survivin.

11 p-regulation of CHK1, CHK2, H2AX, BRCA1, and survivin.

12 ors (CHK1 and CHK2), and anti-apoptosis gene survivin.

13 hway, was implicated in the up-regulation of survivin.

14 phorylated form of the antiapoptotic protein survivin.

15 arian cancer cells through downregulation of survivin.

16 orylation and key survival factors, Mdm2 and Survivin.

17 its down-stream targets Aurora kinase B and survivin.

18 cent findings showing that Notch2 suppresses survivin (a key inhibitor of apoptosis), FIH targeting i

19 Survivin, a homodimeric member of the Inhibitor of Apopt

20 a concomitant drop in the protein levels of survivin, a member of anti-apoptotic proteins and a know

21 NA encoded by KSHV upregulates expression of survivin, a member of the inhibitor of apoptosis (IAP) f

22 epithelia decreases the protein abundance of survivin, a member of the inhibitor of apoptosis family.

23 Survivin, a member of the inhibitor of apoptosis protein

24 onversely, siRNA-mediated down-regulation of survivin activated caspases and enhanced the sensitivity

25 Anti-apoptotic survivin, along with other inhibitor of apoptosis (IAP)

26 tion to its role in inhibition of apoptosis, survivin also regulates mitosis.

27 The subsequent increase in survivin among transit amplifying cells promotes epithel

28 The target gene was survivin, an anti-apoptotic protein induced by chemother

29 The target gene was survivin, an inducible chemoresistance gene.

30 Survivin, an inhibitor of apoptosis (IAPs) family member

31 Survivin, an inhibitor-of-apoptosis protein, was also do

32 Survivin, an overexpressed anti-apoptotic protein in can

33 (CD31 and VE-cadherin) expression, increased survivin and Ajuba expression, and a reduction in Hippo

34 Combined blockade of survivin and application of chimeric T cells in vivo sup

35 T/mTOR pathways and stimulating proapoptotic survivin and BAX pathways.

36 ase-3 and PARP, while reducing expression of survivin and Bcl-2.

37 AmEpCs up-regulated anti-apoptotic proteins survivin and Bcl-xL by mechanisms dependent and independ

38 Amniotic membranes naturally expressed both survivin and Bcl-xL, indicating that fetal membranes cou

39 on of INCENP forms a three-helix bundle with Survivin and Borealin, directing the CPC to the inner ce

40 Here, we reveal that in addition to Survivin and Borealin, the single alpha-helix (SAH) doma

41 ated the latter in H. pylori-induced loss of survivin and cell viability.

42 These demonstrated that the mRNA of survivin and CUG-BP1 each contain two functional miR-214

43 pithelial cells leads to an increase in both survivin and CUG-BP1 mRNA and protein.

44 , using miR target prediction programs, both survivin and CUG-BP1 mRNA were found to contain potentia

45 rease in the mRNA and protein levels of both survivin and CUG-BP1.

46 in esophageal cancer cells by targeting both survivin and CUG-BP1.

47 se-3 cleavage, and upregulated expression of survivin and cyclin B1.

48 n completely reversed the paclitaxel-induced survivin and enhanced the paclitaxel activity (p<0.05).

49 lyze the requirements for core CPC subunits, survivin and INCENP, and the mitotic kinesin-like protei

50 R reduces p85alpha and TP53, which increases survivin and intestinal epithelial cell expansion during

51 omotes the ubiquitylation and degradation of survivin and is inhibited by CUL7.

52 issue were assessed immunohistochemically by survivin and Ki-67 staining.

53 ted decrease in protein levels of Cyclin Ds, Survivin and Mcl-1 is independent of transcription or pr

54 /Akt/mTORC1 mechanism elevates expression of Survivin and promotes growth of prostate epithelial cell

55 of adherens junction molecule modulation of survivin and the Hippo pathway in the proliferation and

56 omplex ClpXP associates with the oncoprotein survivin and the respiratory chain Complex II subunit su

57 6(INK4a) contributes to the up-regulation of survivin and thereby provides a survival advantage to ce

58 sed a siRNA against the chemoresistance gene survivin and two model polyanion drugs (suramin, heparin

59 cules, including c-myc, axl, CTGF, cyr61 and survivin and upregulation of the tumor growth inhibitor

60 tment induced reduction of CK2alpha, Bcl-xL, survivin and xIAP protein expression along with suppress

61 ng anti-apoptosis factors (MCL-1, PTTG1, and survivin) and cell-cycle regulators (c-Myc).

62 ed regulation of c-MYC, GSK3beta, p27(KIP1), survivin, and components of the RB pathway, resulting in

63 -CATENIN target genes, CYCLIN D1, c-MYC, and SURVIVIN, and enhanced lymphoma cell death.

64 rgets of STAT3, including cyclin D1, bcl-XL, survivin, and micro-RNA-21.

65 nal epithelial cells had less Trp53 and more survivin, and relative responses to resection were blunt

66 pha, nuclear factor of activated T cells and survivin, and signal transducers and activators of trans

67 tical survival pathways, including RAS, p53, survivin, and the BCL2 family of cell death regulators.

68 ukin-13 receptor alpha 2 (IL-13Ralpha2), and survivin, and their peptide epitopes were emulsified in

69 F1-alpha (hypoxia-inducible factor-1 alpha), survivin, and VWF (Von Willebrand factor).

70 Finally, Survivin antagonists impede growth of MB cells in vivo.

71 sensor with covalently bound monoclonal anti-survivin antibody can detect Sur with the limit of detec

72 e-potential barrier layer structure and anti-survivin antibody.

73 NF-kappaB and survivin are coordinately up-regulated in GBM patient tu

74 a cells, and two siRNAs specific to EGFR and survivin are fused between two aptamers.

75 Consistently, both alphavbeta6 and survivin are significantly increased in prostatic adenoc

76 ll cycle regulators, including cyclin D1 and survivin, are downregulated in the germinative zone of t

77 es IGF-I-stimulated cell growth, implicating Survivin as a mediator of this growth response.

78 a lines in vitro, supporting the validity of survivin as an attractive therapeutic target for high-gr

79 insulted CA1 neurons and identify STAT3 and survivin as potentially important therapeutic targets in

80 uction of phosphorylation of the oncoprotein survivin at residue T34.

81 nase B (AK-B) and induces phosphorylation of survivin at residue T34.

82 ther cell cycle regulators such as Aurkb and survivin, Aurka is required for hematopoiesis, but is di

83 The in-situ applications of survivin biomarkers' detection technologies to equip nan

84 s of the inner-centromere-targeting proteins survivin (Bir1), borealin (Nbl1), Bub1 and Sgo1.

85 CENP-A chaperone HJURP(Scm3), CENP-C(Mif2), Survivin(Bir1), and INCENP(Sli15); and a reduced chromat

86 endent expression of the prosurvival protein survivin (BIRC5) and attenuation of sensitivity to EGFR

87 gulation of several survival factors such as survivin (BIRC5) and Bcl-xL (BCL2L1) when cells were exp

88 n of transcription of the antiapoptosis gene survivin (BIRC5) and the CSC-associated cytokine interle

89 anti-apoptotic and proliferation-associated survivin (BIRC5) gene generates six isoforms, which regu

90 short form of c-FLIP (FLIP(S), CFLAR(S)) and survivin (BIRC5).

91 downregulated transcriptional expression of survivin (BIRC5a).

92 vated apoptotic proteins BAD, cytC, c-casp3, Survivin, BIRC7.

93 Together, our results suggest that survivin blockade is required for therapeutic responses

94 In conclusion, survivin blockade provides a strategy to sensitize RMS c

95 mposed of inner centromere protein (INCENP), Survivin, Borealin, and the kinase Aurora B, contributes

96 ces while mTORC2 represses the expression of Survivin by IGF-I.

97 biquitylation and proteasomal degradation of survivin by interacting with Glu-126 within its carboxyl

98 uces Survivin expression, and that silencing Survivin by lentiviral-mediated small hairpin RNA (shRNA

99 Down-regulation of survivin by siRNA or pharmacologically in RMS cells incr

100 cumventing ciliary function by re-expressing survivin can rescue polycystic kidney disease phenotypes

101 red with controls, whereas the extracellular survivin CD4(+) percentage was unaffected.

102 n of known p53-repression targets, including survivin, CDC25C, and CDC25B in response to p53 inductio

103 Compared with wild-type survivin, cellular expression of a survivin mutant prote

104 eased expression of anti-apoptotic proteins (survivin, cIAP-2, XIAP), induced apoptosis, and arrested

105 ntained a higher percentage of extracellular survivin compared with controls.

106 tory vesicles containing the HSP90alpha-AHA1-survivin complex toward the leading edge.

107 and a codon-optimized form of the human TAA survivin (coSVN), an oncoprotein that is overexpressed i

108 Survivin could be detected in the small intestine and as

109 f anti-apoptotic molecules Bcl-2, Bcl-xL and survivin, coupled with down-regulation of signaling path

110 mediates Gas6/Axl-mediated overexpression of survivin, cyclin D1 and FAK, leading to enhanced surviva

111 dependent translation of mRNAs which include Survivin, Cyclin D1 and Mcl-1.

112 ery, B cell homeostasis is not affected, but survivin-deficient B cells are unable to mount humoral r

113 LQZ-7F induced proteasome-dependent survivin degradation, mitotic arrest, and apoptosis, and

114 e compound that induced proteasome-dependent survivin degradation.

115 l for stimulating apoptosis through XIAP and survivin degradation.

116 as, the most severe lesions in the biallelic survivin deleted mice were high-grade prostatic intra-ep

117 of the animals with wild-type or monoallelic survivin deletion developed adenocarcinomas, the most se

118 as a cellular marker for proliferation, and survivin demonstrated a coincidental localization of the

119 ets of eIF4E-mediated translation, including survivin, demonstrated that eIF4E(S209) phosphorylation

120 , understanding the mechanisms that regulate survivin DEx3 mRNA AS is clearly important.

121 ance the exclusion of exon 3 to generate the survivin DEx3 mRNA isoform.

122 the first clues regarding the regulation of survivin DEx3 mRNA splicing.

123 One of the isoforms is survivin DEx3, in which the exclusion of exon 3 generate

124 ffolds that can directly bind to and inhibit survivin dimerization.

125 r, chemical inhibition of either Aurora B or survivin does not target CPC specifically due to off-tar

126 , but the clinical pathology associated with survivin downregulation or knockout has never been studi

127 a role in cystic kidney and aneurysm through survivin downregulation.

128 In this article, we show that deletion of survivin during early B cell development results in a co

129 immunodominant epitope (Sur20-28) of murine survivin during early stages of thymopoiesis.

130 5, first discovered as a potent inhibitor of Survivin, effectively kills many carcinomas in preclinic

131 Survivin (encoded by BIRC5), the smallest member of the

132 to get deeper insights in the regulation of survivin expression after tissue damage, we also studied

133 chanistically, [pIC](PEI) repressed XIAP and survivin expression and activated an immune response by

134 Furthermore, survivin expression and ciliary localization are regulat

135 ed upregulation of STAT3 phosphorylation and survivin expression and delayed recovery.

136 of PCat-siSurvivin reversed the TPM-induced survivin expression and enhanced the antitumor activity

137 al accumulation of hepatocytes, reduction in survivin expression and prominent regression in tumor si

138 dherin expression correlating with increased survivin expression and YAP nuclear localization, consis

139 d understanding of the mechanisms regulating survivin expression in different cancer cells will be cr

140 However, there is also evidence of survivin expression in differentiated tissues, including

141 e the role of microRNAs (miRs) in regulating survivin expression in esophageal cancer cells.

142 I induces the renoprotective upregulation of survivin expression in kidney epithelial cells, but the

143 ls, consistent with TCR signaling induced by survivin expression in the murine thymus.

144 There is rather limited information on survivin expression in the small intestine.

145 ed animal survival and, as expected, induced survivin expression in tumors.

146 sion analysis found an increase in bcl-2 and survivin expression induced by 4-1BB that was associated

147 vels of survivin from cancer cells with high survivin expression levels.

148 osphorylation and subsequent upregulation of survivin expression mediated by Notch-2 signaling in ren

149 a more detailed and thus complete picture of survivin expression patterns in the gastrointestinal tra

150 pletion by antimycin A treatment upregulated survivin expression through a phospho-STAT3-dependent pa

151 ults suggest that there is already a maximal survivin expression under normal conditions.

152 whether the observed effect of miR-214-3p on survivin expression was direct, mediated through CUG-BP1

153 PCNA Cyclin D1 Cyclin E and Survivin expression was measured by Western blot.

154 tentiates apoptotic cell death by inhibiting survivin expression, a member of the inhibitor of apopto

155 ine as a model, we showed that IGF-I induces Survivin expression, and that silencing Survivin by lent

156 thway involving cilia function or structure, survivin expression, cytokinesis, cell ploidy, symmetric

157 Moreover, we show that PDT inhibited survivin expression.

158 Bcl-2, Bcl-xL, Mcl-1, cyclin D1, c-Myc, and survivin expression.

159 eening of small-molecule inhibitors of human survivin expression.

160 racterized by chromosome instability and low survivin expression.

161 an cancer cells to PTX and DOX by inhibiting survivin expression.

162 tor of apoptosis repeat-containing 5 (BIRC5; survivin) expression) is synergistically cytotoxic acros

163 guish healthy cells expressing low levels of survivin from cancer cells with high survivin expression

164 shown that E2F1 directly interacted with the survivin gene (BIRC5) promoter in cells that spontaneous

165 onal mouse and zebrafish models confirm that survivin gene deletion in the kidneys results in a cysti

166 take of ligand-anchored NCs and silencing of survivin gene in a targeted manner.

167 First, we demonstrated that mice lacking the survivin gene in prostate epithelium were fertile and ha

168 line in which the Sam68 binding site in the survivin gene was mutated with the CRISPR/Cas system.

169 However, targeting survivin has been challenging due to its "undruggable" n

170 level of expression in many types of cancer, survivin has long been regarded as a promising therapeut

171 ly overexpressed in cancer cells; therefore, survivin has potential as a target for cancer immunother

172 The inhibitor of apoptosis protein, survivin, has been implicated in many adaptive responses

173 ith a capture DNA sequence for cancer marker survivin, hybridized with a short oligonucleotide bearin

174 Treatment with small-molecule antagonists of Survivin impairs proliferation and survival of both muri

175 sis through downregulating the expression of survivin in breast cancer.

176 We confirmed the increased expression of survivin in CD20(+) lymphocytes from MG patients compare

177 This further supports the decisive role of survivin in cell division.

178 of cancer therapy by inhibiting Aurora B or survivin in different types of cancer including neurobla

179 complex proteins Aurora B kinase (AURKB) and Survivin in early mitosis.

180 g in HUVECs leads to selective repression of survivin in endothelial cells, thus promoting cell apopt

181 he bacterial factors responsible for loss of survivin in gastric cells exposed to H. pylori.

182 f STAT3 and STAT3-dependent transcription of survivin in insulted CA1 neurons and identify STAT3 and

183 The current study examines survivin in intestinal epithelial cells after ileocecal

184 reases activation of STAT3 and expression of survivin in intestinal epithelial cells and expression o

185 omoted activation of STAT3 and expression of survivin in intestinal tumor cells.

186 Restoration of survivin in melanoma cells partially rescued the growth-

187 wed an increased percentage of intracellular survivin in MG patients compared with controls, whereas

188 To further define the role of survivin in MG, we have assessed PBMCs from 29 patients

189 A study with human colon specimens exhibited survivin in most basal crypt epithelial cells of normal

190 Genetic deletion of survivin in Ptch mutant tumor cells significantly inhibi

191 These studies highlight the importance of Survivin in SHH-driven MB, and suggest that it may repre

192 viously identified the antiapoptotic protein survivin in the autoreactive B cells and plasma cells of

193 r cells and post-transcriptionally regulates survivin in these cells.

194 13: to IL-13Ralpha2 in 10, EphA2 in 11, and survivin in three.

195 In infant small bowel, survivin in transit amplifying cells increased 71% after

196 A reduced expression of Ki-67 and survivin in tumor tissues accompanied the observed effec

197 senger complex (CPC; consisting of Borealin, Survivin, INCENP, and the Aurora B kinase) is essential

198 er ileocecal resection, epithelial levels of survivin increased relative to sham-operated on mice, wh

199 Survivin increases proliferation and blunts apoptosis.

200 ads 2 and 3 with kinetics similar to that of Survivin induction.

201 n vivo suppressed tumor proliferation during survivin inhibition.

202 deliver survivin inhibitors, co-delivery of survivin inhibitors with chemotherapeutic agents, synchr

203 cation of nanoparticulate systems to deliver survivin inhibitors, co-delivery of survivin inhibitors

204 further optimization of this novel class of survivin inhibitors.

205 Survivin is a member of the inhibitor of apoptosis famil

206 Survivin is a tumor-associated antigen (TAA) that inhibi

207 Survivin is a unique member of the inhibitor of apoptosi

208 n promoting cell survival and proliferation, survivin is an attractive candidate for targeted therapy

209 Survivin is an essential component of the chromosomal pa

210 Survivin is an inhibitor of apoptosis protein that regul

211 Down-regulation of survivin is at the translational level and is probably m

212 Thus, survivin is essential for proliferation of B cell progen

213 Here we show that Survivin is overexpressed in tumors from patched (Ptch)

214 Correspondingly, we show that survivin is required for cell division in response to mi

215 It was also shown previously that survivin is up-regulated during telomerase-mediated immo

216 nfant small-bowel sections were analyzed for survivin, Ki-67, and TP53 by immunohistochemistry.

217 The finding that in vivo survivin knockdown by PCat-siSurvivin was successful onl

218 Despite the modest effect of survivin knockdown on tumor growth, reduction of the tra

219 parison, PCat-siSurvivin alone did not yield survivin knockdown or antitumor activity, indicating the

220 Survivin knockout also contributes to abnormal oriented

221 Depletion of CUL7 decreases survivin level, and overexpression of survivin rescues t

222 An increase in survivin levels was also detected following C. trachomat

223 s exposed to 100 mGy exhibited elevations in survivin levels, reductions in apoptosis frequencies, an

224 inhibits xenograft tumor growth and induces survivin loss in tumors.

225 Therefore, we hypothesized that Survivin may have a critical role in growth and survival

226 acrylate nanoparticles (PMMA-NPs) to promote survivin MB uptake in human A549 cells was investigated.

227 e the ability of the PMMA-NPs to promote the survivin-MB internalization, suggesting that this comple

228 This survivin-mediated adaptive response has the potential fo

229 be induced in vascular-specific normotensive survivin mice.

230 vin) was active in cultured cells (decreased survivin mRNA and protein levels, reduced cell clonogeni

231 apy and a Molecular Beacon (MB) specific for survivin mRNA is available.

232 portantly, these LNA nanoparticles knockdown survivin mRNA, an established target for cancer therapy,

233 activity in a vector carrying the 3'-UTR of survivin mRNA.

234 wild-type survivin, cellular expression of a survivin mutant protein deficient in its ability to inte

235 poly(ADP ribose) polymerase, and suppressed survivin, myeloid cell leukemia 1, Bcl-xL, cyclin D1, an

236 ffect is abrogated with rescue expression of survivin or CUG-BP1.

237 therapeutic agents, synchronous targeting of survivin, other drug resistant molecules, and survivin r

238 ancer samples analyzed showed BRCA1-IRIS and survivin overexpression and lacked nuclear FOXO3a expres

239 Survivin overexpression is associated with cancer, but t

240 target gene expression, activated caspase-3, survivin, p85alpha, and Trp53.

241 We propose a 3M-CUL9-survivin pathway in maintaining microtubule and genome i

242 utic potential of an Ab raised to a modified survivin peptide but cross-reactive to survivin.

243 rived TCRs had tighter interactions with the survivin peptide than did fratricidal TCRs.

244 CR-Tg mice, which cannot effectively present survivin peptides on class I major histocompatibility co

245 Strikingly, Survivin, previously suggested to target the CPC to cent

246 The expression of survivin proceeds during embryonic development and in ad

247 , reduction of the translationally regulated survivin profoundly inhibited motility and metastasis of

248 PR, AR, Bcl-2, HER2, p53, E-cadherin, Ki67, survivin, prolactin, FOXA1) for survival impact.

249 ation assay, we demonstrate occupancy of the survivin promoter by CBP that is decreased by ICG-001 in

250 n antisurvivin drug that interferes with Sp1-survivin promoter interactions, and survivin small inter

251 a, which lowers TP53 activation and releases survivin promoter repression.

252 minicircles that use the pan-tumor-specific Survivin promoter to drive expression of a secretable re

253 or growth but also significantly induced the survivin protein level in residual tumors, whereas addit

254 way of a collective result of suppression of survivin protein, beta-catenin, and mammalian target of

255 sponsible for the procancerous properties of survivin proteins.

256 esents an overview of the mechanism by which survivin regulates cell function, followed by a discussi

257 urvivin, other drug resistant molecules, and survivin regulators.

258 reases survivin level, and overexpression of survivin rescues the defects caused by CUL7 depletion.

259 ence-mediated or pharmacologic inhibition of survivin restored sensitivity to trastuzumab in resistan

260 lotinib and the small-molecule antagonist of survivin, S12.

261 Furthermore, both Lys-90 and Lys-91 within survivin serve as ubiquitin acceptor sites.

262 The chimera is able to inhibit EGFR and survivin simultaneously and induce apoptosis effectively

263 PCat-loaded with survivin siRNA (PCat-siSurvivin) was active in cultured

264 study, an effective, safe and biocompatible survivin siRNA encapsulated, GalNAc decorated PEGylated

265 e-specific membrane antigen, and loaded with survivin siRNA, inhibited prostate cancer xenograft.

266 Likewise, survivin siRNA-loaded and folate-displaying extracellula

267 of an adaptive response if transfected with survivin siRNA.

268 with Sp1-survivin promoter interactions, and survivin small interference RNA (siRNA) transfection eli

269 Application of HLA-A2-restricted survivin-specific T cell receptors (TCRs) isolated from

270 Here, we identified an HLA-A2-restricted survivin-specific TCR isolated from autologous TCR reper

271 Phosphorylation of survivin specifically on residue T34 enhances the activi

272 Phosphorylation of survivin specifically on residue T34 upregulates the act

273 Phosphorylation of survivin specifically on residue T34 upregulates the act

274 receptor-specific Abs, and decreased CD19(+) survivin(+) splenocytes.

275 Moreover, a small-molecule inhibitor of survivin strongly impaired the growth of representative

276 d the antitumor activity of a small-molecule survivin suppressant YM155 alone and in combination with

277 tems and biosensors for the detection of two survivin (Sur) biomarkers: the Sur protein and its messe

278 The anti-apoptotic protein survivin (Sur) plays an important role in the regulation

279 of apoptosis proteins (IAP) family, protein survivin (Sur), a ubiquitous re-organizer of the cell li

280 ting the current limitations associated with survivin-targeted therapies and speculating on the futur

281 owed by a discussion of the current state of survivin-targeted therapies.

282 providing preclinical proof of concept for a survivin-targeting anticancer agent, our work offers nov

283 We generated mice (survivin-TCR-transgenic [Sur-TCR-Tg]) expressing a TCR r

284 y inhibiting dimerization of the oncoprotein survivin, thereby promoting its degradation along with s

285 The ability to target survivin through Ab recognition of autoreactive cells of

286 orylation and prevents Histone H3 binding to survivin, thus providing mechanistic insight of how Sang

287 omplex that regulates CUL9 and its substrate survivin to link mitosis to cell survival.

288 rentially expressed antigen of melanoma, and survivin to patients with relapsed/refractory solid tumo

289 get of rapamycin complex 1 (mTORC1)-mediated survivin translation by ERK and AKT signaling.

290 ng siRNAs (Bcl-2, P-glycoprotein [P-gp], and survivin) via encapsulation and surface coordination, re

291 Likewise, expression of survivin was detected in the ischemically damaged small

292 The expression of survivin was downregulated by TP.

293 Survivin was expressed strongly in epithelial cells of s

294 extracellular signal-related kinase 1/2, and survivin were determined by enzyme-linked immunosorbent

295 pathway, and the downstream targets MMP7 and survivin were down-regulated upon BMVC or BMVC4 treatmen

296 allenged by the observation that Bir1 (yeast survivin), which recruits Ipl1-Sli15 (yeast Aurora B-INC

297 egrin, alphavbeta3, promotes upregulation of survivin, which in turn supports anchorage-independent g

298 ining Aurora B kinase, borealin, INCENP, and survivin, which orchestrates chromosome dynamics.

299 cruitment of the CPC requires interaction of survivin with histone H3 phosphorylated at threonine 3,

300 Lewis lung carcinoma, vaccination of the TAA survivin with SA-4-1BBL/MPL yielded superior efficacy ag