ライフサイエンスコーパス: susceptibility loc(us|i)

1 ry loci for a total of 85 cutaneous melanoma susceptibility loci.

2 ments in the fine-mapping resolution at many susceptibility loci.

3 entified multiple renal cell carcinoma (RCC) susceptibility loci.

4 enia (SCZ) in Han Chinese identified several susceptibility loci.

5 eract with the 92 DRE that were found at IBD susceptibility loci.

6 nderstanding the biology of specific disease susceptibility loci.

7 ncorporating information from common genetic susceptibility loci.

8 heterogeneous, with evidence for hundreds of susceptibility loci.

9 nked to >30 insulin-dependent diabetes (Idd) susceptibility loci.

10 :03 (Pcombined=1.83 x 10(-9)) as independent susceptibility loci.

11 d by fixed-effect meta-analyses, to identify susceptibility loci.

12 ysis using Immunochip data have uncovered 36 susceptibility loci.

13 ified numerous common prostate cancer (PrCa) susceptibility loci.

14 wer, leading to the discovery of six new EOC susceptibility loci.

15 as likely causative genes at respective AMD susceptibility loci.

16 cinoma may be attributable to shared genetic susceptibility loci.

17 heterogeneity to discover additional obesity susceptibility loci.

18 ltiple biologically relevant lupus nephritis susceptibility loci.

19 mapping for detecting previously overlooked susceptibility loci.

20 -1 receptor-like 1 (IL1RL1)/IL18R1 as asthma susceptibility loci.

21 tent not previously observed in other cancer susceptibility loci.

22 tive phenotypes to identify putative disease-susceptibility loci.

23 rlap with previously reported SLE-associated susceptibility loci.

24 reveals a strong enrichment for DMRs in T2D-susceptibility loci.

25 e provided strong evidence for 3 genome-wide susceptibility loci.

26 ping studies in the search for CCLE specific susceptibility loci.

27 ere associated with novel, to our knowledge, susceptibility loci.

28 ncluded 94 437 individuals and discovered 24 susceptibility loci.

29 and annotated several cardiovascular disease susceptibility loci.

30 ich is genetically associated with different susceptibility loci.

31 have identified more than 170 breast cancer susceptibility loci.

32 confound attempts to identify additional T1D susceptibility loci.

33 on of PBT heritability attributable to these susceptibility loci.

34 is, revealing new targets that map to asthma susceptibility loci.

35 tifying traits or diseases that share common susceptibility loci.

36 (IFIH1, STAT1, and IRF7) encompassed in SLE susceptibility loci.

37 udies (GWASs) of vitiligo have identified 50 susceptibility loci.

38 ariant and effector transcripts at T2DM GWAS susceptibility loci.

39 8 cases and 13,970 controls) to identify new susceptibility loci.

40 mmary, we provide evidence of five novel SLE susceptibility loci.

41 dies (GWAS) have reported several suggestive susceptibility loci.

42 ve T cells in mice carrying the Sle1a1 lupus-susceptibility locus.

43 tenic with the human 10q22-q23 schizophrenia-susceptibility locus.

44 the 17q12-21 locus, near a well-known asthma susceptibility locus.

45 We identify an additional four susceptibility loci: 11q23.3 CADM1, a metastasis suppres

46 y proxy points to 27 candidate schizophrenia susceptibility loci, 12 of which are associated with sch

47 tive immunity and genetic variants on asthma susceptibility locus 17q21.

48 H (CFH) and A69S in age-related maculopathy susceptibility locus 2 (ARMS2).

49 Here we show the discovery of four new BCC susceptibility loci: 2p24 MYCN (rs57244888[C], OR=0.76,

50 We identified 25 new susceptibility loci, 3 of which contain integrin genes t

51 gies have led to the discovery of 242 common susceptibility loci, 45 of which have been fine-mapped t

52 The major AF susceptibility locus 4q25 establishes long-range interac

53 -9) for the leading rs259919) and two cancer susceptibility loci 6p21.32 (rs3135001, HLA-DQB1) and 6p

54 selection plausibly acted on a human disease susceptibility locus, a form of balancing selection comp

55 We identified 18 susceptibility loci achieving genome-wide significance,

56 We identified 16 additional psoriasis susceptibility loci achieving genome-wide significance,

57 ave led to the identification of hundreds of susceptibility loci across cancers, but the impact of fu

58 We found that up to 35% of the susceptibility loci affect in vitro cytokine production

59 ls, including 27 new genome-wide significant susceptibility loci and 3 unreported shared risk loci.

60 sociation between genetic variants at 21 T2D-susceptibility loci and all-cause mortality in an elderl

61 m six East Asian cohorts to identify new SLE susceptibility loci and better localize known loci.

62 tion between 12 GWAS-identified hypertension-susceptibility loci and cardiotoxicity in a cohort of lo

63 We identified shared susceptibility loci and commonalities in pathways betwee

64 we used an alternative approach to annotate susceptibility loci and identify candidate genes for hum

65 s and Epidemiology (PAGE) study, we identify susceptibility loci and investigate pleiotropy among gen

66 Our results highlight several promising new susceptibility loci and reinforce the importance of lyso

67 We identify new CBD susceptibility loci and show that CBD and PSP share a ge

68 to examine the molecular mechanisms of known susceptibility loci and to detect and interpret pleiotro

69 the general population to a potential autism susceptibility locus and a linkage region for dyslexia,

70 e functional landscape of the 11q23.3 glioma susceptibility locus and identify a network of functiona

71 k alleles carried at 27 validated common CRC susceptibility loci), and history of endoscopic examinat

72 iously published loci, we discovered six new susceptibility loci, and further gene prioritization ana

73 e 2 diabetes risk variants at 37 established susceptibility loci, and indices of proinsulin processin

74 22.2-22.1 schizophrenia and bipolar disorder susceptibility locus, and additional neurodevelopmental

75 We thus identify a sexually dimorphic IS susceptibility locus, and propose the first functionally

76 We conclude that PTPRG is an ischemia susceptibility locus; and RPTPgamma-dependent sensing of

77 pped and examined for enrichment for disease susceptibility loci annotated in the genome-wide associa

78 ciation (GWA) studies-identified lung cancer susceptibility loci assessed, a variant (rs2808630) of t

79 tudies (GWAS) have identified 11 independent susceptibility loci associated with bladder cancer risk.

80 smoking women have previously identified six susceptibility loci associated with lung cancer risk.

81 ation studies (GWAS) have identified over 41 susceptibility loci associated with Parkinson's Disease

82 and 83,943 male controls) to identify novel susceptibility loci associated with PCa risk.

83 (GWAS) have identified thousands of germline susceptibility loci associated with risk for cancer as w

84 04 controls, among which we identified 3 new susceptibility loci at 11q12 (rs174549), 6p21 (rs2857595

85 This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31.

86 P<5.0 x 10(-8)) evidence of 4 additional CHD susceptibility loci at 4q31.22 (rs1400558, upstream of E

87 We also identified two novel susceptibility loci at 5q15 near ERAP2 (rs7705093; OR =

88 Finally, we identify two EOC susceptibility loci at 9q22.33 (rs1413299 in COL15A1, P(

89 ,000 controls, identifies five new psoriasis susceptibility loci at genome-wide significance (P<5 x 1

90 We identified 4 susceptibility loci at genome-wide significance: rs58923

91 We have thus identified a novel susceptibility locus at 3p21, and confirmed previous sug

92 The CLPTM1L gene lies within a cancer susceptibility locus at chromosome 5p15.33 defined by ge

93 ween the immune system, psoriasis-associated susceptibility loci, autoantigens, and multiple environm

94 y is unexplained, indicating that additional susceptibility loci await identification.

95 e frequencies at these and other established susceptibility loci (BMI1, PIP4K2A, and CEBPE) and found

96 d IL1RL1, were previously reported as asthma susceptibility loci, but the effect sizes for these loci

97 2 was identified recently as a neuroblastoma susceptibility locus, but its mechanistic contributions

98 It maps to the PRC1 locus, a type 2 diabetes susceptibility locus, but its specific role in pancreati

99 ested in mapping common and uncommon disease susceptibility loci by focusing on output linking correl

100 ng to functionally interpret complex-disease susceptibility loci by GWAS and eQTL integration have pr

101 or which the goal is to discover new genetic susceptibility loci by leveraging G-E interaction when p

102 eth cells associated with particular genetic susceptibility loci can be used to define specific subty

103 genetic basis of the disease, the identified susceptibility loci can only account for a small portion

104 ts at four established type 2 diabetes (T2D) susceptibility loci (CDKAL1, CDKN2A-B, IGF2BP2 and KCNQ1

105 We use examples of four T2DM susceptibility loci (CDKAL1, MTNR1B, SLC30A8 and PAM) to

106 Many disease susceptibility loci colocalize with DNA regulatory eleme

107 omprehensive analysis of a major albuminuria susceptibility locus detected in these models.

108 -associated loci, suggesting that additional susceptibility loci exist.

109 some 19p13.11 (p = 1.0 x 10(-11) ) as shared susceptibility loci for ALS and FTD-TDP.

110 This meta-analysis discovered 19 susceptibility loci for Alzheimer's disease in populatio

111 vances have been made in identifying genetic susceptibility loci for autoimmune diseases, but evidenc

112 s have driven the discovery of more than 300 susceptibility loci for autoimmune diseases.

113 To search for additional genetic susceptibility loci for breast cancer, here we perform a

114 To identify functional susceptibility loci for breast cancer, we interrogated t

115 East Asian women to search for novel genetic susceptibility loci for breast cancer.

116 The recent identification of over 60 susceptibility loci for CAD confirms not only the import

117 d with lupus, potentially harboring distinct susceptibility loci for CCLE.

118 We discuss genetic susceptibility loci for CD and how these affect Paneth c

119 ation studies (GWAS) have identified several susceptibility loci for childhood acute lymphoblastic le

120 Several susceptibility loci for classical Hodgkin lymphoma have

121 a good alternative method to detect disease susceptibility loci for clinic genomic data.

122 ion studies (GWASs) have identified multiple susceptibility loci for colorectal cancer, but much of h

123 To identify additional susceptibility loci for colorectal cancer, here we perfo

124 ociation Studies (GWAS) have identified many susceptibility loci for common diseases, they only expla

125 Most susceptibility loci for complex dermatologic diseases fa

126 ssociation studies (GWAS) have revealed many susceptibility loci for complex genetic diseases.

127 wide association study (GWAS) identified two susceptibility loci for congenital heart disease (CHD) i

128 gulatory elements that colocalize with known susceptibility loci for coronary artery disease (CARDIoG

129 Genetic susceptibility loci for Crohn's disease (CD) are numerou

130 We discover 16 susceptibility loci for CTS with p < 5 x 10(-8).

131 ieve the large sample sizes needed to detect susceptibility loci for depression.

132 We identified nine new susceptibility loci for different EOC histotypes: six fo

133 ngle nucleotide polymorphisms (SNPs) at four susceptibility loci for diffuse large B-cell lymphoma (D

134 We report two susceptibility loci for DLB at genome-wide significance,

135 To identify genetic susceptibility loci for DLBCL, we conducted a meta-analy

136 In humans, these genes reside in susceptibility loci for epilepsy, and, in flies, we obse

137 vious candidate gene studies suggested a few susceptibility loci for food allergy, but no study inves

138 Conclusion: We identified six susceptibility loci for gallstone disease.

139 nal candidate-gene annotation for 37 disease susceptibility loci for human atherosclerotic disease th

140 city, leading to the hypothesis that genetic susceptibility loci for hypertension may serve as predic

141 nochip genotyping array expand the number of susceptibility loci for IBD in Caucasians to 163, but th

142 We correlated these regions with susceptibility loci for IBD.

143 ommon variants in genomic regions containing susceptibility loci for inflammatory bowel disease and c

144 Genetic studies have identified 163 susceptibility loci for inflammatory bowel disease, most

145 Major susceptibility loci for islet autoantibodies are separat

146 and to investigate relationships with known susceptibility loci for kidney function and lipids.

147 (GWAS) have led to the discovery of several susceptibility loci for leprosy with robust evidence, pr

148 To identify genetic susceptibility loci for MacTel, we performed a genome-wi

149 ubstantially increases the number of genetic susceptibility loci for NSCLP and provides important ins

150 ome-wide interaction study to identify novel susceptibility loci for occupational exposure to biologi

151 ermine whether the identified genes are true susceptibility loci for occupational exposures and wheth

152 udies (GWAS) have identified multiple common susceptibility loci for pancreatic cancer.

153 idence for SMAP1, B3GAT2, and RIMS1 as novel susceptibility loci for pediatric VTE and warrant future

154 STAT4, IL10, and CCR1-CCR3 were significant susceptibility loci for PFAPA, suggesting that the patho

155 We identify two independent susceptibility loci for prostate cancer at 11p15.4 (rs12

156 dies (GWAS) have identified >100 independent susceptibility loci for prostate cancer, including the h

157 the MYC oncogene on chromosome 8q24 contains susceptibility loci for several major forms of human can

158 ion studies (GWAS) have identified dozens of susceptibility loci for SU/gout, but few have been condu

159 tion (GWA) studies have reported 19 distinct susceptibility loci for testicular germ cell tumor (TGCT

160 ighted SNP-scores were built involving known susceptibility loci for the aforementioned traits (53, 7

161 IoGRAM and METASTROKE, are ongoing to reveal susceptibility loci for their underlying disease-atheros

162 studies (GWAS) have identified more than 20 susceptibility loci for these conditions.

163 To identify additional susceptibility loci for this common cancer, we conducted

164 To identify further susceptibility loci for this common, complex skin diseas

165 Known genetic susceptibility loci for type 2 diabetes (T2D) explain on

166 studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most

167 To conclude, we identified 16 novel susceptibility loci for VTE; for some loci, the associat

168 loss in autism, suggest SPRY3 as a candidate susceptibility locus for autism.

169 encoding fetuin-A, has been identified as a susceptibility locus for diabetes and metabolic syndrome

170 The QTL has further been supported as a susceptibility locus for dyslipidemia and related metabo

171 common mutation, perhaps responsible for the susceptibility locus for genetic generalized epilepsy on

172 y, we observed the first example of a common susceptibility locus for genetic mosaicism, specifically

173 We have therefore identified a new susceptibility locus for HPS.

174 STAT4 is highly plausible as a susceptibility locus for invasive NTS disease.

175 IN1) gene within the second most significant susceptibility locus for late-onset AD.

176 ATXN1 was recently nominated as a susceptibility locus for multiple sclerosis (MS).

177 FTO is the strongest known genetic susceptibility locus for obesity.

178 roles in neurodevelopment and is a putative susceptibility locus for schizophrenia.

179 iption factor of HLA class II (HLA-II), at a susceptibility locus for several autoimmune diseases, in

180 We investigated whether the MBOAT7-TMC4 is a susceptibility locus for the development and progression

181 hort of 1,481 individuals and identified two susceptibility loci: for lobar ICH, chromosomal region 1

182 h as discoveries of large numbers of disease susceptibility loci from genome-wide association studies

183 dies have had limited success in identifying susceptibility loci, genome-wide association studies (GW

184 Subsequently, the search for susceptibility loci has been reinvigorated by the use of

185 lay between lifestyle risk factors and these susceptibility loci has not been fully elucidated.

186 mewide association studies, over 50 vitiligo susceptibility loci have been discovered.

187 Over 40 susceptibility loci have been identified for type 1 diab

188 More than 200 susceptibility loci have been identified in populations

189 ory skin disorder for which multiple genetic susceptibility loci have been identified, but few resolv

190 Although several lung cancer susceptibility loci have been identified, much of the he

191 cing dyslipidemia and currently; 157 genetic susceptibility loci have been reported to be associated

192 Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of

193 Thirteen common susceptibility loci have been reproducibly associated wi

194 have identified common risk variants in >100 susceptibility loci; however, the contribution of rare v

195 mer's disease, with the identification of 40 susceptibility loci; however, this does not equate to th

196 Additional susceptibility loci identified at genome-wide significan

197 Susceptibility loci identified by GWAS generally account

198 ion to prioritize candidate genes in disease susceptibility loci identified by GWAS.

199 In addition to susceptibility loci identified in genome-wide associatio

200 tion of genes causing beta cell failure from susceptibility loci identified in type 2 diabetes genome

201 Intriguingly, two PBC susceptibility loci identified through genome-wide assoc

202 tudy, we aimed to investigate whether the OA susceptibility loci identified to date are functioning a

203 eritability for PsA, the majority of genetic susceptibility loci identified to date are shared with p

204 ntribution to prostate cancer, with over 100 susceptibility loci identified to date that can explain

205 MR-MEGA to fine-mapping four type 2 diabetes susceptibility loci in 22,086 cases and 42,539 controls

206 to investigate established RA, IBD, and T1D susceptibility loci in AD.

207 olism (VTE) and identified a number of novel susceptibility loci in adults.

208 substantially increased the number of known susceptibility loci in Alzheimer's disease to 40.

209 e we identified a role for nine genes in IBD susceptibility loci in antibacterial autophagy and chara

210 We recently identified ten novel SLE susceptibility loci in Asians and uncovered several addi

211 sing the Immunochip to determine whether IBD susceptibility loci in Caucasians also affect risk in AA

212 Here we map common genetic susceptibility loci in European ancestry women for the N

213 ing regulatory biofeatures at 17 known HGSOC susceptibility loci in FTSECs (P = 3.8 x 10(-30)), OSECs

214 s have been reproducibly identified as major susceptibility loci in large-scale genome-wide associati

215 rches the NHGRI-EBI GWAS Catalog to identify susceptibility loci in linkage disequilibrium (LD) with

216 (GWAS1 and GWAS2), we identified 27 vitiligo susceptibility loci in patients of European ancestry.

217 NXB, and ERBB3, which had been identified as susceptibility loci in previous genome-wide association

218 We identify four novel inguinal hernia susceptibility loci in the regions of EFEMP1, WT1, EBF2

219 have not previously been identified as TGCT susceptibility loci in these GWA scans, demonstrating th

220 discovered HLA risk factors and four non-HLA susceptibility loci in VPS8, SVEP1, CFL2, and chr13q21 a

221 entified a 3p21.31 gene cluster as a genetic susceptibility locus in patients with Covid-19 with resp

222 te gene for the Idd9.3 type 1 diabetes (T1D) susceptibility locus in the nonobese diabetic (NOD) mous

223 diovascular phenotypes, we identify novel AD susceptibility loci, including 2 genome-wide significant

224 s of this study identify three candidate LSL susceptibility loci, including one that appears to be as

225 We have mapped 43 susceptibility loci, including ten new associations.

226 50-IL13 and IL4), and 12q13 (STAT6) as major susceptibility loci influencing the regulation of total

227 cellular structure affected by schizophrenia susceptibility loci is the actin cytoskeleton, an organe

228 spite the large number of identified disease-susceptibility loci, it is not known which loci influenc

229 gene (MGEA5) is a documented human diabetes susceptibility locus, its role in maintaining insulin-gl

230 n linkage disequilibrium might be unreported susceptibility loci located in the epidermis differentia

231 determine whether, similarly, common cancer susceptibility loci map to genes that have altered frequ

232 A combined analysis identified new susceptibility loci mapping to 3q26.2 (rs10936599, P = 1

233 o date, but the identification of additional susceptibility loci might be important to enhance our un

234 studies (GWAS) have identified ~20 melanoma susceptibility loci, most of which are not functionally

235 pots were enriched in breast cancer germline susceptibility loci (odds ratio (OR) = 4.28) and breast-

236 addition to PLG, the currently known shared susceptibility loci of CAD and periodontitis, ANRIL and

237 Several susceptibility loci of differentiated thyroid cancer (DT

238 , including SLC25A39 and SLC25A40, reside in susceptibility loci of severe forms of epilepsy.

239 ned interactions between smoking and obesity susceptibility loci on BMI.

240 he additive impact of the known adult glioma susceptibility loci on the pediatric brain tumor (PBT) r

241 GWAS have identified a breast cancer susceptibility locus on 2q35.

242 report the discovery of a new endometriosis susceptibility locus on 4q12 (rs17773813[G], OR=1.28; P=

243 imity to the previously reported lung cancer susceptibility locus on 6q.

244 ols of Japanese populations, we identified a susceptibility locus on chromosome 15q24.

245 tudies uncovered a major atrial fibrillation susceptibility locus on human chromosome 4q25 in close p

246 In addition to revealing two new TGCT susceptibility loci, our results continue to support the

247 Our joint analysis identifies new ESCC susceptibility loci overall as well as a new locus uniqu

248 We identified 32 novel susceptibility loci (P < 5.0 x 10(-8)), 15 of which show

249 genetic variation at CSMD1, a schizophrenia susceptibility locus, plays a role in the ratio between

250 In gene regions harboring known susceptibility loci, Primo performs conditional associat

251 These susceptibility loci provide deeper insight into the path

252 We describe six new susceptibility loci reaching a genome-wide threshold of

253 previously reported loci and identify 14 new susceptibility loci reaching genome-wide significance (P

254 These observations suggest that OA susceptibility loci regulate the level of DNA methylatio

255 These two studies identified 27 and 29 susceptibility loci, respectively.

256 Ultimately, we identified a NSCL/P susceptibility loci (rs17095681 at 10q25.3, intron of SH

257 Two GVHD susceptibility loci (rs17114803 and rs17114808) within t

258 de association study (GWAS) has identified a susceptibility locus (rs41270488) for HPV8 seropositivit

259 scovery of the first genome-wide significant susceptibility locus (rs4769613; P = 5.4 x 10(-11)) in 4

260 es of rheumatoid arthritis (RA) identified a susceptibility locus, rs874040(CC), which implicated the

261 ormatics using all 82 loci revealed that SLE susceptibility loci share many gene regulatory features,

262 nforced IL12B, PTK2B, and chr21q22 as robust susceptibility loci shared across ancestries.

263 -DR2 and HLA-DR3, two well established lupus susceptibility loci, showed evidence of association with

264 e Pbx1 that corresponds to the NZM2410 lupus susceptibility locus Sle1a1.

265 ar germ cell tumor (TGCT) have identified 18 susceptibility loci, some containing genes encoding prot

266 ion (ITC-SIS, for short) to detect important susceptibility loci that are associated with the polycys

267 ically analyze chromatin-interactions at IBD susceptibility loci that localize to regulatory DNA.

268 e polymorphisms in lncRNAs, such as the 9p21 susceptibility locus that encodes the lncRNA antisense n

269 and progression of DR, the identification of susceptibility loci through candidate gene approaches, l

270 ction of heritability, discovery of vitiligo susceptibility loci through candidate gene, genomewide l

271 f colorectal cancer (CRC) have identified 23 susceptibility loci thus far.

272 , using a mouse model based on the human SLE susceptibility locus TNFAIP3-interacting protein 1 (TNIP

273 e a mouse model based on the human psoriasis susceptibility locus TNIP1, also referred to as ABIN1, w

274 We identified 19 susceptibility loci to be significantly associated with

275 WAS) have mapped multiple independent cancer susceptibility loci to chr5p15.33.

276 thnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethni

277 studies have identified not only hundreds of susceptibility loci to immune-mediated diseases but also

278 cts demonstrated a high tendency for leprosy susceptibility loci to show association with autoimmunit

279 Known susceptibility loci together can only explain about 6-8%

280 sequencing and targeted resequencing of IBD susceptibility loci), transcriptome information generate

281 were coupled to position a new hypertension-susceptibility locus, uncovering a previously unsuspecte

282 T1D studies and examined to identify new T1D susceptibility loci using molecular inversion probe sequ

283 report a fine-mapping analysis of the 9q31.2 susceptibility locus using 43 160 cases and 42 600 contr

284 NKX2-1 and DIRC3) and identified seven novel susceptibility loci (VAV3, PCNXL2, INSR, MRSB3, FHIT, SE

285 ide chip heritability explained by all known susceptibility loci was 54.2% for luminal A-like disease

286 ly, the aggregated effect of all 170 disease susceptibility loci was not associated with disease prog

287 k score quantifying the risk across multiple susceptibility loci was strongly associated with CC risk

288 To identify new susceptibility loci, we carried out a genetic study of m

289 To identify additional FL susceptibility loci, we conducted a large-scale two-stag

290 To identify new glioma susceptibility loci, we conducted a meta-analysis of fou

291 To identify novel CRC susceptibility loci, we conducted a new GWAS and perform

292 tter understand the genetic basis of the MHC susceptibility loci, we genotyped 7,264 MHC SNPs in 22,6

293 To further discover new susceptibility loci, we imputed data from four GWAS of A

294 In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11

295 To identify new susceptibility loci, we performed a meta-analysis of 11

296 To identify new susceptibility loci, we performed meta-analysis on genom

297 Twenty-three new susceptibility loci were identified at association P < 5

298 Four novel susceptibility loci were identified with genome-wide sig

299 After adjusting for these factors, 100 susceptibility loci were identified.

300 n the allele frequencies and effect sizes of susceptibility loci, which we use to interpret the volum