ライフサイエンスコーパス: sustained

1 occur on the Mexican Pacific coast cannot be sustained.

2 ic ventricular tachycardia/fibrillation (6% [sustained 3%, nonsustained 3%]), ineffectiveness (5%), o

3 Upon DIS3L2 loss, sustained 3'-end uridylation of aberrant 7SL RNA impacts

4 The boy had sustained a bicycle handlebar injury to his upper abdome

5 tudy letters from baseline, as well as first sustained absence of retinal fluid and intraretinal flui

6 Interestingly, 5-ITu causes sustained accumulation of p53, increases markedly the ex

7 a clade of organisms can be explained by the sustained action of natural selection or by a high mutat

8 The persistent population displayed sustained activation following visual cue presentation,

9 We demonstrate that sustained activation of endothelial MAPK causes NF-kappa

10 g in organoids, in part through elevated and sustained activation of mitogen-activated protein kinase

11 lly depends on autocrine IL-3 acting via the sustained activation of STAT5 on the expression of IL-9.

12 xemia and that Zip14 ablation coincides with sustained activity of phosphorylated components of signa

13 ing protein (GAP), providing a mechanism for sustained activity of the RAS ITD protein.

14 ents who responded to lithium; they featured sustained activity with large current injections and a l

15 ation indicating more transient, rather than sustained, activity.

16 Such effects likely contribute to its sustained AD-like activity.

17 nistration of NBQX into the mPFC blocked the sustained AD-like effect of L-655,708.

18 These experiments indicate that the sustained AD-like effects of L-655,708 require protein s

19 p) were followed for 3 weeks: sustained AFL; sustained AF (600 beats/min atrial tachypacing); AF supe

20 Sustained AFL causes atrial repolarization changes like

21 6 dogs per group) were followed for 3 weeks: sustained AFL; sustained AF (600 beats/min atrial tachyp

22 tio, 0.30; 95% CI, 0.22 to 0.42) and was not sustained after that time (week 15 through week 26) (haz

23 The reduction in AIR was also sustained after the first examination (P < .001 to P = .

24 Sero-protection was estimated to be sustained against H1N1pdm09 but to wane by 8-months for

25 of indicator compounds were used to isolate sustained air pollution "events".

26 igher mean pulse rate, beta-blocker use, and sustained albuminuria.

27 a2+]i dynamics observed experimentally after sustained alkalinisation can be reproduced by a model fe

28 IRT3-dependent increases in SOD2 mRNA during sustained anchorage-independence.

29 ficacy benefits with fixed-duration VenR are sustained and particularly durable in patients who achie

30 survival Tasmanian Gondwanan species demands sustained and targeted fire management.

31 o the skin, implanted thin films facilitated sustained and temporal release of individual vaccine com

32 This in turn leads to sustained anomalies in sea ice extent.

33 eptor (NMDAR) antagonist, produces rapid and sustained antidepressant actions in depressed patients,

34 osteric modulator, L-655,708, reproduces the sustained antidepressant-like (AD-like) effect of R,S-ke

35 f GS-9688 is well tolerated and can induce a sustained antiviral response in WHV-infected woodchucks;

36 signals, these neurons produce aversive and sustained appetite-suppressing signals, which discourage

37 se in type 3 cytokines with type 2 mediators sustained at high levels.

38 al atrial fibrosis is a major contributor to sustained atrial fibrillation.

39 Trait-level sustained attention was further quantified using task-ba

40 -theanine, caffeine and their combination on sustained attention, inhibitory control and overall cogn

41 tory infections, but data are conflicting on sustained benefits after intervention discontinuation.

42 nd continuous ocrelizumab treatment provided sustained benefits on measures of disease progression ov

43 We discover that, while elevated, sustained beta-catenin activation sequentially promotes

44 of breastfeeding, and the low prevalence of sustained breastfeeding in this study and Australia in g

45 mers also applied to the steady-state, since sustained Btnl expression is required to maintain the si

46 The liver's cellular functions are sustained by a hierarchical, segmentally-organized vascu

47 vents whose biogeochemical consequences were sustained by a set of positive feedbacks, mediated by th

48 ased phytoplankton biomass, which was likely sustained by an influx of new nutrients.

49 success of cattle herding in Africa has been sustained by dynamic food systems, consumption of a broa

50 reatening lupus, with the clinical responses sustained by maintenance therapy with belimumab, an anti

51 chemoattractant synthesis is triggered by a sustained calcium flux upon contact with necrotic tissue

52 multivesicular bodies (MVBs) is required for sustained canonical Wnt signaling.

53 t of plant growth and the ecosystem became a sustained carbon sink well before winter ended, taking u

54 Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in clinical practice and is

55 Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, is associated with substan

56 stress acclimation, and the consequences of sustained CEF in UWO 241 are not known.

57 Sustained cell migration is essential for wound healing

58 includes how respiratory traits acclimate to sustained changes in the environment.

59 immunogenicity of H5 vaccines.IMPORTANCE The sustained circulation of highly pathogenic avian influen

60 s superior to annual treatment for achieving sustained clearance of Onchocerca volvulus MF from the s

61 r characterization of ecosystem responses to sustained climate change.

62 This results in sustained clinical tolerance, even when treatment has st

63 n participants with hemophilia A resulted in sustained, clinically relevant benefit, as measured by a

64 te that chemotherapy produces early, but not sustained, cognitive impairment relative to E, providing

65 in metastatic uveal melanoma, with deep and sustained confirmed responses.

66 so determined that high-avidity T cells have sustained contacts with intratumoral dendritic cells and

67 cal plasticity is mediated through rapid and sustained cortical disinhibition via downregulation of P

68 y trace interval of several seconds requires sustained cue-elicited firing in the prelimbic cortex (P

69 ing all men and women to DTG would lead to a sustained decline in resistance levels, whereas using DT

70 This substantial and sustained decrease in tumour volume suggests that the pr

71 upporting the use of complex coacervates for sustained delivery of immunostimulatory proteins as an e

72 This study investigated the sustained dentin matrix biomodification and dentin-resin

73 s that span investments in sectors that have sustained direct and indirect impact on nutrition.

74 lso resolved their acute AMR episode and had sustained disappearance of circulating DSA for <=30 mont

75 SSCT with allogeneic donor stem cells led to sustained donor-derived spermatogenesis.

76 Besides sustained drug delivery, AFL-assisted powder reservoir p

77 s (41 and 44 degrees C) reveal a non-Fickian sustained drug release that is well-characterized by Kor

78 respect to incorrect ones, and that this is sustained during the entire trial.

79 GB001 may have a rapid and sustained effect on lung function, particularly in patie

80 Replicating prior work, sustained effects associated with autobiographical recal

81 We need a sustained effort within the enteric fever field to accel

82 ed stringent suppression measures as well as sustained efforts to target those at highest risk becaus

83 Moreover, pharmacologically sustained elevation of zinc in WT eggs prior to activati

84 by magnetically stimulated oxygen stress and sustained enzyme bio-oxidation is thus shown with studie

85 ng these sensors, we showed that EGF induces sustained ERK activity near the plasma membrane in sharp

86 n state, United States, founded the earliest sustained European and North America transmission networ

87 ens, such as influenza and measles, generate sustained exponential growth in incidence and have a hig

88 MYC and Twist1 cooperate and their sustained expression is required to elicit a transcripti

89 ng that loss of ARF strongly correlates with sustained expression of inflammatory and cell survival p

90 Pdap1 deficiency leads to sustained expression of the integrated stress response (

91 Empirically, sustained expression of the redox-sensitive S70pBcl2 pre

92 ome this half-life ceiling and maintain high sustained factor VIII activity levels.

93 population activity through its powerful and sustained feedforward inhibition.

94 Individual interneurons did not display sustained firing but instead transiently enhanced their

95 icular to an interface and develop into self-sustained flow convection cells.

96 No sustained focal activity was observed.

97 e aerobic exercise on inhibitory control are sustained for 60 min in children with ADHD.

98 However, a full lockdown cannot be sustained for a prolonged period.

99 Chlorhexidine release was sustained for almost 2 months and the material efficacy

100 one mechanism by which fat oxidation can be sustained for long periods without deleterious effects o

101 ) 0%, p=0.80) in 16 studies, particularly if sustained for more than 1 year (crude OR 0.62, 0.47-0.81

102 These parameters were consistently sustained for over 1 year after the 6-week optimization.

103 seen early after initiation of treatment and sustained for the duration of double-blind therapy.

104 y characterized photoprotection mechanism, a sustained form of nonphotochemical quenching (sustained

105 eal (90% coverage or adoption) scale-up, and sustained from 2020 to 2030, with outcomes evaluated unt

106 , improvements in mNIS+7 with patisiran were sustained from parent study baseline with treatment in t

107 ine) showed a higher incidence rate of first sustained gain of 15 letters or more than eyes with occu

108 Sustained gazing, such as in silent reading, has a measu

109 erein, we present a polymeric NP system with sustained gene delivery properties, which can be synthes

110 s in colder regions such as the Arctic under sustained global warming, but with complex and not neces

111 3.6 Ma) is the most recent past interval of sustained global warmth with mean global temperatures ma

112 Sustained gluten exposure reliably induces histologic ch

113 hort course of rapamycin regimen resulted in sustained graft survival and function in >90% of allogen

114 Included are a batch culturing system for sustained growth of subject-specific gut microbial commu

115 Unexpectedly, sustained H3K36me3 deposition is dependent on HP1gamma.

116 gin of the GBM resection cavity to provide a sustained high local dose with reduced systemic toxiciti

117 istic intermediate dynamics distinguished by sustained high spindle activities.

118 cued AnxA6(-/-) mice survival after PHx, the sustained hypoglycemia in partially hepatectomized AnxA6

119 ercapnia or after the exposure to short-term sustained hypoxia.

120 the achievement of cure in RA by triggering sustained immune activation and effector cytokine produc

121 nary data argued in favor of substantial and sustained immune pressure exerted upon a developing tumo

122 overy are associated with distinct early and sustained immunologic and endothelial biomarker signatur

123 Durvalumab plus platinum-etoposide showed sustained improvement in overall survival versus platinu

124 RUX cream provided rapid and sustained improvements in AD symptoms and was well toler

125 Higher baseline CRF and sustained improvements in CRF and weight loss were assoc

126 Nemolizumab resulted in rapid and sustained improvements in cutaneous signs of inflammatio

127 body-mediated depletion of NK cells leads to sustained improvements in neurogenesis and cognitive fun

128 Medication reduction was sustained in 187 (66.3%) participants at 12 weeks.

129 r limit to the number of species that can be sustained in stable equilibrium by an ecosystem.

130 global value maximum signals are delayed and sustained in the AH body.

131 is factor-alpha (TNF) treatment were largely sustained in the FLS exposed to chronic inflammation.

132 to understanding how cone-mediated vision is sustained in vivo.

133 he patients and a VT was either inducible or sustained/incessant in 85% of the cases.

134 A sustained increase in intracellular Ca(2+) concentration

135 (BMDMs) showed that LPS treatment induced a sustained increase in NF-kappaB activation and expressio

136 An additional sustained increase in NOD1 abundance to 1.5-fold over ba

137 se in DAG levels, unlike the robust and more sustained increase induced by muscarinic receptor activa

138 s or their bone marrow progenitors, mediates sustained increased responsiveness to secondary challeng

139 ver, patients with persistent opioid use had sustained increases in spending by approximately $200 pe

140 Sustained, indolent immune injury of the vasculature of

141 ammation, the lack thereof may contribute to sustained inflammation and impaired healing in chronic w

142 of CL, supporting participation of parasite-sustained inflammation or deregulated innate immune resp

143 on pressure-volume curve (5-45 cm H2O) and a sustained inflation recruitment maneuver (45 cm H2O for

144 h clear and meconium-stained amniotic fluid, sustained inflations for initiation of positive-pressure

145 e covalent inhibitor, compound 15a exhibited sustained inhibition of SRC signaling both in vitro and

146 regulated kinase (ERK) pathways mediated the sustained inhibitory actions of endogenous opioids and D

147 ritical thickness beyond which the otherwise sustained interfacial reactions are arrested.

148 s underlines the importance and potential of sustained intervention regarding the skin pH and urges f

149 glaucoma provides effective IOP reduction or sustained IOP control and meaningful medication reductio

150 Cataract surgery was more likely to yield sustained IOP reduction for patients with primary open-a

151 logy of innate immunity and to determine how sustained ISG upregulation can be compatible with robust

152 s an intrinsic castration-resistant and self-sustained lineage that emerges early during prostate dev

153 ntrations at some sites are primarily due to sustained local emissions, while the low concentrations

154 the release of nucleic acid drug payload for sustained, long-term gene expression or silencing.

155 ound that cyclin D2(-/-) mice had robust and sustained loss of long-term memory in two separate behav

156 vaccination with a biennial disease pattern, sustained low rates of rotavirus in children < 3 years o

157 tivate the postsynaptic receptors generating sustained low-amplitude current and desensitize the rece

158 steroid allows for initial proliferation and sustained M. abscessus pulmonary infection and permits e

159 inducing anxiety in a simple, consistent and sustained manner.

160 pulation contributes to impede the spread of sustained measles epidemics, rather than favoring it.

161 In contrast, sustained mesoaccumbal inactivation greatly reduced moti

162 The primary end point was a sustained molecular response in the bone marrow after th

163 findings led to a more recent proposal that sustained MOR signaling caused analgesic tolerance.

164 , we found that flies, like humans, perceive sustained motion in the stationary gradients.

165 nsive LC polymers, shape programmability and sustained motions to finally achieve bioinspired untethe

166 Th1 cells exhibited significantly higher and sustained mTOR activity than effector T-bet- (non-Th1) A

167 ates the effects of fibroblasts resulting in sustained MTOR signaling and poor lapatinib response.

168 by fibroblasts in tumor cells that exhibited sustained MTOR signaling due to a strong gain-of-functio

169 rowth beyond Ras-transformed tumor cells via sustained mTORC1 activation.

170 nologic responses; juvenile mice displayed a sustained myeloid infiltrate (including monocytes and ne

171 jury secondary to the collateral damage from sustained myocardial inflammation within the infarct zon

172 uted to axon degeneration/neuronal death and sustained neuroinflammation.

173 Self-sustained Ni(I/III) cycles are established as a potentia

174 ustained form of nonphotochemical quenching (sustained NPQ).

175 identified one of the involved cell types as sustained ON alpha-ganglion cells.

176 on mission requirements of night shift work, sustained operations, and rapid re-entrainment to time z

177 The beneficial effects of sustained or lifelong (>25 years) endurance exercise on

178 ence of de-novo ventricular arrhythmias (non-sustained or sustained ventricular tachycardia or ventri

179 h, to implement comprehensive change that is sustained over decades, and scaled up into the entire gl

180 an excellent low-temperature performance is sustained over hydrothermal aging and sulfation as a res

181 served that this enhanced lysosomal state is sustained over time and defines an adaptive homeostasis

182 could potentially result in major losses if sustained over time.

183 se that is released from mitochondria during sustained oxidative stress.

184 Sustained P2RX7 signaling was required for long-term Trm

185 Sustained pharmacological inhibition of autophagy using

186 These results demonstrate that sustained physiologic hyperglycemia for 72 h 1) increase

187 studies also demonstrate the requirement for sustained PI supply from the ER for the maintenance of m

188 nd primordia patterning that results in self-sustained planar intercalations.

189 y driven by aeolian vibration, enabling self-sustained PM adhesion.

190 iEEG deconvolution revealed sustained positive responses to visual-only speech and l

191 Sustained postoperative surveillance for all patients is

192 whether an increase in hydrogen peroxide is sustained posttreatment and potential mechanisms involve

193 nds and Maillard products are related to the sustained production of H(2)O(2) over time, which in tur

194 on in mice, leading to high mortality due to sustained production of pro-inflammatory cytokines.

195 disorders of muscle wasting associated with sustained proinflammatory signaling.

196 Sustained proliferation is a significant driver of cance

197 of hepatic steatosis, and 4) evidence for a sustained protection against steatosis induced by exerci

198 patients, adverse event in 34 patients, and sustained quiescence in 25 patients.

199 More recently, it was proposed that sustained, rather than reduced, MOR signaling caused tol

200 and synovial fluid samples from 30 dogs that sustained RCCL and 9 clinically healthy dogs were analyz

201 receptor domain is responsible for the Fls3-sustained reactive oxygen species, suggesting involvemen

202 TNFR1 transport to cell membrane, leading to sustained receptor responsiveness and downstream NF-kapp

203 bstinence, alcohol-dependent patients showed sustained recovered mGluR5 availability in cortical and

204 The rate ratio for a sustained recovery was 1.06 (95% CI, 0.77 to 1.47).

205 uring the first 3 years of warming where the sustained reductions in soil inorganic N could not meet

206 U.S.-born residents was projected to produce sustained reductions in TB incidence.

207 ansplantation, and PEAD-base Coa exhibited a sustained release of bioactive IGF-1 over 3 weeks.

208 Additionally, successful treatments require sustained release of drug payloads to maintain the effec

209 ntly encapsulate nucleic acid cargo, exhibit sustained release of payload, and can stably transfect c

210 nstrate that membrane budding results in the sustained release of platelets directly into the periphe

211 neutrophil-mediated lung metastasis via the sustained release of Zileuton.

212 on, prolonged circulation, reduced toxicity, sustained release, and improved efficacy.

213 ns of CsA-loaded DIANAs in mice provided CsA sustained release, decreasing alloantigen-induced immune

214 Additionally, sustained-release NP-EFs, administered 24 h prior to inf

215 tes achieved high GRFT loading, and provided sustained-release of GRFT for up to 90 d.

216 -electrospun fiber (EF) composite to provide sustained-release of GRFT, and to examine its safety and

217 Furthermore, we develop a slow sustained-release strategy to overcome the limited dispe

218 A majority of patients had sustained remissions.

219 et genes in T2D-PTECs that may contribute to sustained renal dysfunction in DKD.

220 This environment relies on sustained research support, commitment to providing the

221 ngaging 16-18-year-old A level biologists in sustained research.

222 l to ~15 months, most patients do not have a sustained response to treatment.

223 treatment is expected to achieve a rapid and sustained response, the response at a fixed time point d

224 ces of ~220 nN and pressures of ~5.6 kPa and sustained responses at higher forces of ~360 nN and pres

225 as expressed as the selective suppression of sustained responses to low-identity faces.

226 We tested whether fragmentation of sustained rest/activity patterns derived from actigraphi

227 pigmentosa, a lead compound, Q525, afforded sustained RET activation and prevented photoreceptor neu

228 We hypothesized that sustained RTK signaling, because of decreased TRIAD1 act

229 mitter switching provides the basis by which sustained running benefits motor skill learning, present

230 tized S1P(1) These findings demonstrate that sustained S1P(1) activation can occur pharmacologically

231 The induction of sustained sensitivity and nociception without joint dama

232 According to sustained sensitization in tiers 1 and 2, T cell-related

233 elucidate when, where, and how the earliest sustained severe acute respiratory syndrome coronavirus

234 ellular signalling, such as through tonic or sustained signalling after ligand engagement.

235 eleration, distance to goal, and licking) in sustained slow firing modulation.

236 MOC neurons diminishes over the course of a sustained sound.SIGNIFICANCE STATEMENT Medial olivocochl

237 Overall, our findings demonstrate that sustained spatial attention alone, even in the absence o

238 ls, but not PV+ cells, significantly reduces sustained spectral surround suppression in excitatory ce

239 neration of F-actin bundles required for the sustained stabilization of highly contractile actomyosin

240 These results signal the need for sustained stringent suppression measures as well as sust

241 nitoring, beyond the scope of TAS, to ensure sustained success.

242 ter 104 livebirths, classified as reflecting sustained suppression (31 [30%]), rebound viraemia (55 [

243 Posttransplant, sustained suppression of 3 of 3, 4 of 6, and 8 of 8 DSA

244 c patients who died had early, profound, and sustained suppression of innate and adaptive immunity.

245 dorse the use of whole-genome sequencing for sustained surveillance of NTS internationally.

246 to infection with B. burgdorferi resulted in sustained swelling, as well as histopathological changes

247 Specifically, superior sustained systemic and mucosal HIV Gag-specific poly-fun

248 t offers the promise of clean power for self-sustained systems(1,2).

249 ss during chronic T cell stimulation allowed sustained T cell proliferation and induced genes associa

250 and release of the depot coincided with the sustained TAF release.

251 re to Ags, such as chronic viral infections, sustained TCR signaling can result in T cell exhaustion

252 The primary end point was sustained testosterone suppression to castrate levels (<

253 A sustained TFR lower than the replacement level in many c

254 polymer depots with p(Alkyl-TAFMA) exhibited sustained TFV and TAF release profiles in skin and blood

255 Only the 1 and 25Hz rTMS groups sustained the improvements in TUG, and had a significant

256 To achieve a sustained therapeutic efficacy and reduced toxicities, m

257 These reductions were sustained through to days 28 and 29 (p = 0.050 and p = 0

258 eosinophil subgroups, respectively) and were sustained through treatment completion.

259 have formed within days, if these rates are sustained throughout pegmatite formation.

260 Exposure was dose-proportional and sustained throughout the dosing period for all patients

261 on aryl bromides as well as on heteroarenes sustained throughout the standard reaction conditions fo

262 reating residents of index households over a sustained time period could contribute to malaria elimin

263 s is the first time that high-dose week-long sustained transdermal delivery of hydrophilic drugs was

264 The genetic data reflect sustained transmission within reservoir areas, further e

265 The ability of sustained treatment of a single extraocular muscle with

266 tors and ADRs persisted in mice and produced sustained tumor eradication in two mouse models of allog

267 on, reducing protein glycosylation, causes a sustained Unfolded Protein Response (UPR), a significant

268 Eighteen subjects underwent an optional sustained unresponsiveness assessment; 14 of those (77.8

269 in LNCaP tumor xenografts, and this peak was sustained up to 120 h after injection.

270 climate change mitigation, assuming primary, sustained use of LPG for daily cooking.

271 We found that sustained use over two weeks was accompanied by increase

272 Prior sustained VA and the extent of functional heart disease

273 Altogether, these results suggest that sustained VDR levels in beta-cells may preserve beta-cel

274 o lentiviral transfection was used to induce sustained VDR-KD in C2C12 cells to analyse myogenic regu

275 Secondary outcomes included sustained ventricular tachyarrhythmia and appropriate IC

276 vo ventricular arrhythmias (non-sustained or sustained ventricular tachycardia or ventricular fibrill

277 or therapy, resuscitated cardiac arrest, and sustained ventricular tachycardia).

278 mal heart, and is at least as susceptible to sustained VF as the untreated failing heart.

279 e-ART, are the main features associated with sustained viral control after ATI in SIV-infected RMs.IM

280 Children <18 years at ART initiation, with sustained viral suppression (VS) (<=400 copies/mL) for >

281 rapy associated with increased likelihood of sustained virologic response (SVR) and an association be

282 Key outcomes included sustained virologic response (undetectable HCV RNA 12 we

283 The primary efficacy endpoint was sustained virologic response 12 weeks after therapy (SVR

284 in in 12 centers across Thailand to estimate sustained virologic response at post-treatment week 12 (

285 Sustained virologic response was high in nonadherent (89

286 treatment course, and 61 (50%) have achieved sustained virologic response.

287 HIV drug resistance (HIVDR) is a barrier to sustained virologic suppression in low- and middle-incom

288 started on treatment, which can result in a sustained virological response (effective cure).

289 ple living with hepatitis C virus (HCV) with sustained virological response (SVR) develop hepatic com

290 a (HCC) in HCV-infected patients who achieve sustained virological response (SVR) with direct-acting

291 Sustained virological response at 12 weeks post-treatmen

292 us infection (which was treated, achieving a sustained virological response when she was 18 years old

293 generated new antiviral CD8 T cells, despite sustained virus replication in the thymus, indicating an

294 Cumulative incidence of time to first sustained vision gain of 15 or more Early Treatment Diab

295 The devices produce a sustained voltage of around 0.5 volts across a 7-microme

296 LMM aRR 0.85, 95% CI 0.83 - 0.87 and lack of sustained VS (N=2,499; LR aRR 0.75, 95% CI 0.68 - 0.83;

297 The incidence and timing of CHB or sustained VT within 30 days post-ASA were assessed.

298 material resonances in chalcogenide crystals sustained well inside the mid-infrared, choosing Bi(2)Te

299 nts in auditory and vestibular function were sustained well into adulthood.

300 ng dynamics, were switched from transient to sustained when receptor internalization was inhibited wi