ライフサイエンスコーパス: swine

1 e is an economically significant pathogen of swine.

2 IAV was concurrently detected in exhibition swine.

3 dovascular approach for inducing ischemia in swine.

4 l access under general anesthesia in healthy swine.

5 ction for virus replication and virulence in swine.

6 iral virulence in the natural host, domestic swine.

7 ion of protective immunity, and virulence in swine.

8 y and irrigated radiofrequency ablation in 3 swine.

9 of great economic and welfare importance in swine.

10 red ASL secretion in CFTR(-/-) and wild-type swine.

11 the development of PEDV-induced diarrhea in swine.

12 ion with avian IAVs are reported in domestic swine.

13 , consistent with further host adaptation to swine.

14 SFV-G produces complete virus attenuation in swine.

15 etween explanted human lungs and a Yorkshire swine.

16 current seasonal human H1pdm co-circulate in swine.

17 amily Bovidae shared the most pathogens with swine (82%).

18 Of 15 swine, 9 had inducible VT (5.2+/-3.0 per animal) while i

19 Swine acute diarrhea syndrome coronavirus (SADS-CoV) is

20 ses, as evidenced by the recent spillover of swine acute diarrhoea syndrome coronavirus (SADS-CoV) to

21 ated ASL height increase in CF and wild-type swine airway.

22 Recent IDV outbreaks in swine along with serological and genetic evidence of IDV

23 Pandemic influenza A viruses can emerge from swine, an intermediate host that supports adaptation of

24 power and standard power were compared in 4 swine and 100 consecutive patients referred for PVI.

25 novel picobirnavirus most closely related to swine and dromedary viruses.

26 lecular basis for the mixing vessel trait of swine and further our understanding of the evolution and

27 Genomic analysis showed that the swine and human isolates were nearly identical.

28 bot and the combined system was validated in swine and human patients.

29 ewed showed significant similarities between swine and human skin, as previously published.

30 ewed showed significant similarities between swine and human skin, as previously published.

31 us replication, ANP32A, is different between swine and humans.

32 acilitates IAV transmission among exhibition swine and into humans.

33 type 2 is an important bacterial pathogen of swine and is also an emerging zoonotic agent that may be

34 ta-2) that becomes dominant among exhibition swine and is associated with the majority of zoonotic in

35 Swine and patient samples were studied using bulk RNA se

36 For example, swine and rat plasmas demonstrated similar TG, but swine

37 tially reduce IAV transmission in exhibition swine and spillover into humans, and this merits further

38 pressurized skeletal muscle arterioles from swine, and (3) humans.

39 , subsequently spilling over into exhibition swine, and caused a majority of H3N2 variant (H3N2v) cas

40 Swine ANP32A allows a greater range of influenza viruses

41 We map the enhanced proviral activity of swine ANP32A to a pair of amino acids, 106 and 156, in t

42 In this study, we describe how swine ANP32A, uniquely among the mammalian ANP32 protein

43 ere economic losses in the pork industry and swine are key intermediate hosts of human disease outbre

44 Swine are often described as "mixing vessels," being sus

45 ffecting the ability of avian IAVs to infect swine are still not fully understood.

46 Outbreaks have killed millions of swine around the world, and there is currently no vaccin

47 In swine arteries, the BEM increases cellular proliferation

48 rk helps to explain the unique properties of swine as mixing vessels.

49 rtment does not result in the acquisition of swine-associated genes and swine virus genomic sequences

50 hm, and random forest algorithms to identify swine-associated sequences in the hemagglutinin gene to

51 tic signatures can differentiate circulating swine-associated strains from circulating human-associat

52 -oxygen-level-dependent (BOLD) activation in swine brain.

53 ae and pose major threats for the horse- and swine-breeding industries worldwide.

54 try into mammalian species such as humans or swine, but they only continue to transmit if they accumu

55 ) was established in mechanically ventilated swine by adjusting the tidal volume.

56 ntraluminal imaging was performed in healthy swine carotid arteries.

57 d with the parental virus, in an established swine cell line (SK6) and in primary swine macrophage cu

58 tween DCTN6 and E2 proteins in CSFV-infected swine cells by using two additional independent methodol

59 l impact of the mutation on interaction with swine cells was consistent with an alternative mechanism

60 outcomes were favorable neurologic outcome (swine Cerebral Performance Category <= 2) and mitochondr

61 is variable in terms of its size and type of swine, counties in states historically known for breedin

62 DNA virus (NCLDV) that causes a devastating swine disease currently present in many countries of Afr

63 ndrome (PRRS) is one of the most significant swine diseases.

64 ission demonstrated for the H3.2010.1 IAV in swine emphasizes the need for further characterization o

65 PEDV), porcine deltacoronavirus (PDCoV), and swine enteric alphacoronavirus (SeACoV).

66 20 s versus 50 W.10 s) were performed at the swine epicardium.

67 l cells, and a relatively small reduction in swine epithelial cells.

68 CFTR(-/-) swine ex-vivo tracheal preparations showed substantially

69 collected from individuals exposed to IAV at swine exhibitions (n = 7) or while working at live bird

70 illness onset, while another did not report swine exposure.

71 exposure and infection status of individual swine facilitates introduction, transmission, and dissem

72 study the impact of confined and controlled swine farm environments on temporal changes in the gut m

73 personnel from waste pits at two sites on a swine farm in North Carolina.

74 In conclusion, sustainable swine farming management can be beneficial for both anim

75 infections had previously been performed in swine, ferrets, calves, and guinea pigs in order to stud

76 rospray ionization (DESI) - MS of a complete swine fetus at 50 days of gestation.

77 African swine fever (ASF) is a devastating disease for domestic

78 African swine fever (ASF) is a severe viral disease that is curr

79 e absence of any available vaccines, African swine fever (ASF) outbreak containment relies on the con

80 srupt its own replication.IMPORTANCE African swine fever (ASF) poses a major threat to pig population

81 fecal microbiota composition of the African swine fever (ASF) resistant warthogs (Phacochoerus afric

82 e is no effective vaccine to control African swine fever (ASF), and therefore, efficient disease cont

83 All pigs developed acute forms of acute swine fever (ASF).

84 Surveillance of Classical Swine Fever (CSF) should not only focus on livestock, bu

85 The E2 protein in classical swine fever (CSF) virus (CSFV) is the major virus struct

86 African swine fever causes substantial economic losses in the sw

87 the causative pathogen of the recent African swine fever epidemic, with devastating impacts on econom

88 novel companion software script, the African swine fever fast analysis sequencing tool (ASF-FAST), th

89 se in domestic pigs and wild boar, classical swine fever is recognised by the World Organisation for

90 m which the capping enzyme NP868R of African swine fever virus (ASFV) and the T7 RNA polymerase were

91 African swine fever virus (ASFV) causes a lethal hemorrhagic dis

92 African swine fever virus (ASFV) causes a lethal, haemorrhagic d

93 African swine fever virus (ASFV) causes hemorrhagic fever in dom

94 this devastating disease.IMPORTANCE African swine fever virus (ASFV) causes incurable and often leth

95 The CD2-like African swine fever virus (ASFV) gene 8DR, (also known as EP402R

96 However, the recombination events in African swine fever virus (ASFV) genomes have been poorly annota

97 African swine fever virus (ASFV) is a complex nucleocytoplasmic

98 African swine fever virus (ASFV) is a complex, cytoplasmic doubl

99 African swine fever virus (ASFV) is a highly pathogenic, double-

100 African swine fever virus (ASFV) is among the most complex DNA v

101 African swine fever virus (ASFV) is contagious and can cause hig

102 African swine fever virus (ASFV) is the causative agent of a sev

103 African swine fever virus (ASFV) is the causative pathogen of th

104 tion protocols, naturally attenuated African swine fever virus (ASFV) isolate OURT88/3 and deletion m

105 and isothermal detection system for African Swine Fever Virus (ASFV).

106 Classical swine fever virus (CSFV) is the causative agent of class

107 ing caused by circulating strains of African swine fever virus derived from the Georgia 2007 isolate.

108 omegalovirus support plasmid for the African swine fever virus NP868R capping enzyme.

109 In the case of African swine fever virus vaccine candidates, this issue has rec

110 ht play an important role.IMPORTANCE African swine fever, a devastating disease for domestic pigs and

111 s (CSFV) is the causative agent of classical swine fever, a notifiable disease of economic importance

112 mmercially available vaccine against African swine fever.

113 of bacterial spores, proteins, and classical swine fever.

114 uted worldwide to combat the H1N1 influenza "swine flu" pandemic.

115 Disease outbreaks such as SARS, MERS, Swine Flu, Ebola, and COVID-19 (on-going) have caused su

116 Most shipments carried young swine for feeding or breeding purposes and carried a med

117 ofrequency lesions were delivered in 4 and 1 swine from the inferior vena cava onto a forcefully devi

118 Results Swine gross necropsy did not show any extracardiac damag

119 o characterize longitudinal variation in the swine gut microbiome, the extent to which a host's genom

120 Here, the swine gut microbiota and liver transcripts were investig

121 study was to characterize antigenically the swine H1 IAVs circulating in Chile.

122 g variations in serologic data for human and swine H1N1 IAVs.

123 2010.1 to differentiate it from the previous swine H3 virus.

124 3N2 (H3.2010.1) influenza A virus (IAV) from swine has been frequently detected in commercial and exh

125 ASFV isolates showing decreased virulence in swine has been shown to be non-hemadsorbing suggesting a

126 Novel H1N2 influenza A viruses (IAVs) in swine have been identified in Chile co-circulating with

127 om complex mixtures extracted from human and swine heart tissue.

128 s work, we developed computational models of swine hearts to study the electrophysiological vulnerabi

129 Efficient infection of primary human and swine hepatocytes using the developed protocol could be

130 Preclinical swine hindlimb transplantation models have an important

131 imens from the skin component of heterotopic swine hindlimb transplants.

132 imens from the skin component of heterotopic swine hindlimb transplants.

133 urveillance comprising nearly 2,500 European swine holdings and more than 18,000 individual samples i

134 otein-protein interaction between E2 and the swine host protein DCTN6 during virus infection.

135 wo-hybrid system, we previously identified a swine host protein, dynactin subunit 6 (DCTN6) (a compon

136 s with A(H1N1)pdm09 viruses originating from swine hosts and classify them as "swine-origin" variant

137 ows that these viruses not only circulate in swine hosts, but are continuing to evolve and distinguis

138 ll hemagglutinin subtypes of IAVs can infect swine; however, only sporadic cases of infection with av

139 aracterization of viruses circulating at the swine-human interface for transmission potential prior t

140 ish a model for evaluating the propensity of swine IAV to transmit from pig to ferret as a measure of

141 al for zoonotic transmission associated with swine IAV, we performed an in vivo study of transmission

142 ited information on the genetic diversity of swine IAVs within farrow-to-wean farms, which is where m

143 identify antigenic variants of subtype H3N2 swine IAVs.

144 Derby) subtypes in human and swine identified isolates with a distinct PFGE profile t

145 Genetic analysis highlighted that Italian swine IDVs are closely related to the D/swine/Oklahoma/1

146 ic H1N1 (pH1N1) influenza virus emerged from swine in 2009 with an adequate capability to infect and

147 ases have been children who had contact with swine in agricultural fairs.

148 ts highlight the need to update vaccines for swine in Chile and the importance of continued surveilla

149 s discovered in Escherichia coli in domestic swine in China that conferred resistance to colistin, an

150 uently detected in commercial and exhibition swine in recent years and has been associated with H3N2

151 and genetic sequencing of IAVs in exhibition swine in six U.S. states in 2018 (n = 212), we character

152 d that one individual had direct exposure to swine in the week preceding illness onset, while another

153 ide a national-level characterization of the swine industry by quantifying the demographic (i.e. age,

154 t poses serious economic consequences to the swine industry due to the high mortality rate and impact

155 utbreaks of this disease are devastating the swine industry from Central Europe to East Asia, and the

156 er causes substantial economic losses in the swine industry in affected countries.

157 The disease is devastating the swine industry in Central Europe and East Asia, with cur

158 work, therefore, suggests that although the swine industry is variable in terms of its size and type

159 Our study suggests that the US swine industry may be vulnerable to infectious disease o

160 auses enormous economic losses to the global swine industry.

161 36% of swine operations and 63% of the U.S. swine industry.

162 ng significant economic losses to the global swine industry.

163 rging pathogen detection that appeals to the swine industry.

164 t viral pathogen, causing huge losses to the swine industry.

165 in pigs, posing a great economic loss to the swine industry.

166 Swine influenza A viruses (swIAVs) can play a crucial ro

167 equence comparison of the variant viruses to swine influenza genomes.

168 The results suggest swine influenza viruses containing both a stabilized HA

169 For swine influenza viruses isolated in 2009-2016, gamma-cla

170 Critically, both human and swine influenza viruses replicated in the immortalized c

171 all proposed to have been caused by avian or swine influenza viruses that acquired virulence factors

172 Since its detection in swine, influenza D virus (IDV) has been shown to be pres

173 measures to limit the dissemination at human-swine interfaces to reduce the risk of zoonotic infectio

174 amics of IAV transmission through exhibition swine is critical to mitigating the high incidence of va

175 ining positive proof-of-concept results with swine kidneys, we studied donated human kidneys undergoi

176 (HLA) antibody cross-species reactivity with swine leukocyte antigen (SLA).

177 Swine leukocyte antigens play indispensable roles in imm

178 blished swine cell line (SK6) and in primary swine macrophage cultures.

179 unoff and soil following land application of swine manure slurry.

180 Economic models for the entire US swine market revealed that following across-the-board ac

181 Using porcine swine mesenteric arteries, the effects of up to 6-day in

182 Using a swine model (n=9), we demonstrate that to induce a 1 uV

183 data with histopathological evaluation of a swine model of concussion demonstrated a notably similar

184 irculation platform in a clinically relevant swine model of gastric aspiration injury.

185 ent (LGE) and myocardial wall thickness in a swine model of healed left ventricular infarction.

186 a similar transcriptome was identified in a swine model of MI and in heart tissue from patients with

187 n our previous studies using a translational swine model of RVD.

188 recently performed a feasibility study in a swine model using high doses of high-energy C-ions to ta

189 tion of kidney and liver in an acute in vivo swine model was evaluated for 6 animals.

190 Materials and Methods An in vivo swine model was used (n = 4, ~50 kg) for 20 procedures g

191 In the swine model, lung collapse and intratidal recruitment/de

192 -loop method to dynamically modulate RA in a swine model.

193 kinetics for 1 mo in vitro and in vivo in a swine model.

194 ac metabolism, and mitochondrial function in swine models of acute myocardial infarction.

195 lution ex-vivo CMR images in 20 post-infarct swine models who underwent an electrophysiology study fo

196 Then, we create a swine movement network using the estimated probabilities

197 Swine movement networks among farms/operations are an im

198 he objectives of this work are: (1) estimate swine movement probabilities at the county level from co

199 e a P663-L663 substitution in the endogenous swine MYO5B (corresponding to the P660L mutation in huma

200 In these studies, we isolated primary swine nasal and tracheal respiratory epithelial cells an

201 espiratory epithelial cells and immortalized swine nasal epithelial cells (siNEC) and tracheal epithe

202 d higher-titer viral isolates from human and swine nasal swabs, supported the replication of isolates

203 -origin viruses adapt and become enzootic in swine, nascent reverse zoonoses may result in virus dete

204 uated the propensity of a 2010.1 H3N2 IAV (A/swine/Ohio/A01354299/2017 [sw/OH/2017]) isolated from a

205 tudy, we rescued the recombinant influenza D/swine/Oklahoma/1314/2011 (D/OK) virus by using a bidirec

206 lian swine IDVs are closely related to the D/swine/Oklahoma/1334/2011 cluster.

207 2011 from eight states that represent 36% of swine operations and 63% of the U.S. swine industry.

208 and production, and improve the economics of swine operations in the global agro-food system.

209 % of wastewater treatment plant capacity and swine operations that generate ~500 M tons/y manure.

210 plications were stopped 2 s (study group and swine) or 5 s (control group) after unipolar signal modi

211 Swine origin A(H3N2) variant (A(H3N2)v) viruses continue

212 Swine origin A(H3N2) variant [A(H3N2)v] viruses continue

213 ], the Hong Kong flu of 1968 [H3N2], and the swine origin flu of 2009 [H1N1]) are all proposed to hav

214 riable sites exist in H3N2 IAVs of human and swine origin, where the number of head glycosylation sit

215 on of the 2009 pandemic H1N1 IAV of Eurasian swine origin.

216 The swine-origin A(H1N1) variant cases were resolved by full

217 ne to differentiate between human-origin and swine-origin A(H1N1)pdm09 viruses.IMPORTANCE Influenza v

218 y responsible for driving antigenic drift in swine-origin H3 IAV.

219 work, we have identified the first case of a swine-origin influenza A(H1N1)pdm09 virus resulting in a

220 Rarely, an avian- or swine-origin influenza virus adapts to humans and starts

221 We further show that after the swine-origin influenza virus emerged in humans and cause

222 tures can be used to enhance surveillance of swine-origin influenza.

223 chniques for distinguishing human-origin and swine-origin viruses are necessary for the continued sur

224 etections that are difficult to classify as "swine-origin" or "human-origin" due to the genetic simil

225 ating from swine hosts and classify them as "swine-origin" variant influenza viruses based on phyloge

226 disease surveillance and control for endemic swine pathogens in the United States.

227 y of conducting noninvasive surveillance for swine pathogens through the study of swine slurry.

228 nary study was to explore if we could detect swine pathogens using a non-invasive, indirect approach

229 and rat plasmas demonstrated similar TG, but swine plasmas did not generate plasmin.

230 virus (PEDV), which causes acute diarrhea in swine, plays a role in antagonizing the innate response

231 2011 IAV season was introduced into the U.S. swine population and termed H3.2010.1 to differentiate i

232 age became widespread in the U.S. commercial swine population, subsequently spilling over into exhibi

233 ke influenza viruses circulating in the U.S. swine population.

234 The spread of pathogens in swine populations is in part determined by movements of

235 Thus, European swine populations represent reservoirs for emerging IAV

236 e the movement probabilities among different swine populations.

237 gs were cloned by transfer of chromatin from swine primary fetal fibroblasts, which were edited with

238 The method was validated on fish or swine processed food products contaminated at 5 mug g(-1

239 pig whipworm Trichuris suis is important in swine production because of its negative effects on pig

240 r period (2000 to 2016) from the poultry and swine production chains, in Brazil, were investigated by

241 Domestic swine production in the United States is a critical econ

242 used for routine surveillance in commercial swine production systems.

243 uctive performance is critical for efficient swine production.

244 Enabled by cross-circulation with a living swine, prolonged extracorporeal support of damaged lungs

245 Exhibition swine represent a small, defined population (~1.5% of th

246 Swine represent the only livestock with an established i

247 We have developed immortalized swine respiratory epithelial cells that retain the abili

248 a A viruses (IAVs) circulating in exhibition swine, resulting in over 450 lab-confirmed zoonotic infe

249 Phase II: in 8 swine, right atrial lines were created in the posterior

250 Struvite-bearing solids from swine (S) and dairy (D) wastewater, heat-treated to 150-

251 and biphasic (PFA(Bi)) waveforms in 7 and 7 swine sequentially and irrigated radiofrequency ablation

252 irus, but also against all human, avian, and swine serotypes and, therefore, potential pandemic strai

253 assortants within pig populations.IMPORTANCE Swine serve as a mixing vessel for generating pandemic s

254 ly no large-scale quantitative assessment of swine shipments available to support risk assessments.

255 We characterize annual networks of swine shipments using a 30% stratified sample of Interst

256 atterns, and the production diversity within swine shipments.

257 eted mitigation strategy, such as postponing swine shows for 1 to 2 weeks following the early-season

258 characterized how a heterogeneous circuit of swine shows, comprising fairs with different sizes and g

259 ride removal by electrodialysis.Methods: Ten swine (six treated and four control animals) were sedate

260 Two hundred fourteen swine skin biopsy specimens were reviewed, including 88

261 214 swine skin biopsy specimens were reviewed, including 88

262 r, unified grading criteria for rejection in swine skin have not yet been established.

263 From April to November 2018, 105 swine slurry samples were collected by farm personnel fr

264 Such swine slurry surveillance may supplant the need to handl

265 nce for swine pathogens through the study of swine slurry.

266 sive, indirect approach through the study of swine slurry.

267 f the monocyte-macrophage lineage, affecting swine species and provoking severe economic losses and h

268 Notable swine-specific characteristics, including pauci-cellular

269 Notable swine-specific characteristics, including paucicellular

270 c3, human-specific HF183/BFDrev and CPQ_056, swine-specific Pig-2-Bac, and cattle-specific Bac3qPCR a

271 The identification of higher-risk swine strains can then be targeted for control measures

272 es to mitigate human exposure to higher-risk swine strains.

273 In in-vivo swine studies (N = 17), 12-lead ECG signals were recorde

274 During ex vivo human and in vivo swine studies, the device consistently delivered the mic

275 Both mechanisms fail in CFTR(-/-) swine, suggesting that cystic fibrosis airways do not re

276 e used genomic sequences from our exhibition swine surveillance to characterize the hemagglutinin and

277 We conducted in vivo studies in rats and swine that support the applicator's safety and, using in

278 s a lethal, haemorrhagic disease in domestic swine that threatens pig production across the globe.

279 In swine the upper reproductive tract undergoes early postn

280 airs bring people into intimate contact with swine, they provide a unique interface for zoonotic tran

281 ak to replicate in ferrets and transmit from swine to ferret.

282 a A viruses (IAV) sporadically transmit from swine to humans, typically associated with agricultural

283 Human-to-swine transmission of seasonal influenza viruses has led

284 performed in nine 12-week-old domestic male swine under general anesthesia by using fluoroscopic gui

285 Adult swine underwent 20 minutes of circulatory arrest, induce

286 Twenty-two swine underwent 7 minutes of asphyxia followed by ventri

287 to replicate well in epithelial cells of the swine upper respiratory tract, and these viruses were sh

288 suggests that the tissue tropisms (i.e., in swine upper respiratory tracts) of avian IAVs affect the

289 iphasic, 24 amperes) were investigated in 25 swine using a lattice-tip catheter and system (Affera In

290 urate comparison of rejection in preclinical swine VCA models.

291 In vivo phase: in 9 swine, ventricular ablation at Tmax60 degrees C versus 4

292 he acquisition of swine-associated genes and swine virus genomic sequences are not available from the

293 ducible VT (5.2+/-3.0 per animal) while in 6 swine VT could not be induced despite stimulation from 4

294 Two cohorts of 6 swine were treated with pulsed fields at low dose (PF(LD

295 maternal immune activation (MIA) model using swine, which results in altered social behaviors of pigl

296 omposition with growth and carcass traits in swine, while also identifying putative host genetic mark

297 studied during low/high PEEPs in a model of swine with ARDS and high P(PL) (n=9) versus healthy swin

298 Six swine with healed myocardial infarction underwent cardio

299 ARDS swine with high P(PL) demonstrated unchanged transmural

300 ith ARDS and high P(PL) (n=9) versus healthy swine with normal P(PL) (n=6).