ライフサイエンスコーパス: symport

1 mbrane of Escherichia coli (galactoside/H(+) symport).

2 upling galactoside and H(+) transport (i.e., symport).

3 Escherichia coli membrane (galactoside/H(+) symport).

4 ts vicinity affect the pK(a) of glucose/H(+) symport.

5 s offer a mechanistic model for lactose/H(+) symport.

6 se pathway following uptake via sugar:cation symport.

7 conserved glutamate residue mediates proton symport.

8 mobile barrier mechanism for cation-coupled symport.

9 at may be essential for effective H(+)/sugar symport.

10 sm that deviates from the canonical model of symport.

11 terminal domain to initiate galactoside/H(+) symport.

12 de mechanistic insights into Na(+)/melibiose symport.

13 the proteoliposome lumen due to H(+)-proline symport.

14 hat also permits a facultative NO(2)(-)/H(+) symport.

15 ally involved in the mechanism of sugar/H(+) symport.

16 o this site triggers Na(+)-coupled substrate symport.

17 likely to underlie LacY-catalyzed sugar/H(+) symport.

18 nt state that is essential for Na(+)-coupled symport.

19 out this process, it may be driven by proton symport.

20 a mechanical switch device for H(+)-coupled symport.

21 is suggested to result from H(+)-amino acid symport.

22 phatase activity acting as a chloride/proton symport.

23 ports and a bumetanide-sensitive Na+-K+-2Cl- symport.

24 ivotal role in the mechanism of lactose/H(+) symport.

25 rter to uncouple sugar transport from proton symport.

26 counterflow, neither of which involves H(+) symport.

27 osine transporter from the Nucleobase-Cation-Symport-1 (NCS1) transporter family, a member of the wid

28 The nucleobase-cation-symport-1 (NCS1) transporters are essential components o

29 During sugar/H(+) symport, a cavity facing the periplasmic side is thought

30 Galactoside/H(+) symport across the cytoplasmic membrane of Escherichia c

31 transporters have low-to-modest H(+) /Cl(-) symport activity and their mechanism of action remains l

32 east expressing Slc11a orthologues show that symport activity is ancestral.

33 old increase in perchlorate-sensitive Na+/I- symport activity over background.

34 acrocycle that has a record-high H(+) /Cl(-) symport activity similar to that of prodigiosin and most

35 During sugar/H(+) symport, an outward-facing cavity is thought to open wit

36 Despite the availability of structures, the symport and antiport mechanisms still need to be clarifi

37 ies, we propose a mechanism for glucose/H(+) symport and discuss the symport mechanism versus facilit

38 p via a specific proton-coupled electrogenic symport and that this transport is essential for parasit

39 An energy landscape for symport and uniport is presented.

40 relationship between PAT1 (H(+) /amino acid symport) and NHE3 (N(+) /H(+) exchange) explains the app

41 of Escherichia coli catalyzes L-fucose/H(+) symport, and a crystal structure in an outward-facing co

42 driven by the inter- play of different ions (symport, antiport) or by ATP consumption (ATPases).

43 s, where they are energized and regulated by symported, antiported and allosteric ions on both sides

44 tration gradient, both of which involve H(+) symport, Arrhenius plots with wild-type permease exhibit

45 325 in helix X is obligatory for lactose/H+ symport at a step corresponding to deprotonation of lact

46 n, catalyzes stoichiometric galactoside/H(+) symport by an alternating access mechanism and exhibits

47 LacY catalyzes symport by an alternating access mechanism.

48 ional carrier model, accounts for diminished symport by H322N mutant; how H322 mutants become uniport

49 Sugar/H(+) symport by lactose permease (LacY) utilizes an alternati

50 Lactose/H(+) symport by lactose permease of Escherichia coli involves

51 A mechanism proposed for lactose/H(+) symport by the lactose permease of Escherichia coli indi

52 s the role of TM1 in Na(+)-coupled substrate symport by the SSSs, here we have studied the role of a

53 ers that use either facilitated diffusion or symport can have a rate-affinity tradeoff, where an incr

54 Therefore, lactose/H(+) symport catalyzed by LacY very likely involves a global

55 pose a possible mechanism for lactose/proton symport (co-transport) consistent with both the structur

56 he low-affinity, high-capacity, arabinose/H+ symport, conserves the ATP expended in pentose transport

57 rs that facilitate transmembrane H(+) /Cl(-) symport (cotransport) have anti-cancer potential due to

58 ication was countered by the chloride/proton symport cycloprogidiosin.

59 the primary site, thereby functioning as a "symport effector." Because tricyclic antidepressants bin

60 e transport protein of the nucleobase-cation-symport family and a member of the widespread 5-helix in

61 ch are conserved in the oligosaccharide/H(+) symport family of the major facilitator superfamily.

62 Moreover, in the ground state, the symported H(+) is shared between His-322 (helix X) and G

63 Moreover, in the ground state, the symported H(+) is shared between His322 (helix X) and Gl

64 s-319 with Asp-240 paradoxically inactivates symport; how some multiple mutants become revertant tran

65 ted before sugar binding during lactose/H(+) symport in either direction across the membrane.

66 appear essential not only for sodium-coupled symport in general but also for the function of other ty

67 ) transporters in plants and that Na(+)/K(+) symport in HKT proteins is associated with a glycine in

68 e measured SUT1 mRNA levels and sucrose-H(+) symport in leaf discs.

69 wing: (i) The limiting step for lactose/H(+) symport in the absence of the H(+) electrochemical gradi

70 recently proposed mechanism for lactose/H(+) symport in which substrate binding induces a conformatio

71 bound to the neurotransmitter glutamate with symported ions, potassium ions, sodium ions alone, or wi

72 oor affinity for sugar, and galactoside/H(+) symport is abolished as well.

73 An energy profile for symport is also presented.

74 hSMVT-mediated Na(+)/I(-) symport is inhibited by the other three organic hSMVT su

75 chieve million-fold transmitter gradients by symporting it with three sodium ions and a proton, and c

76 ies to gain insights into the cation-coupled symport mechanism for Na(+)-coupled MFS transporters.

77 ing conformation have led to a model for the symport mechanism in which both sugar and H+ binding sit

78 owever, understanding of the cation site and symport mechanism is still vague.

79 ns with LeuT-like fold, in the Na(+)-coupled symport mechanism of SSSs.

80 membrane, leading to an unusual H(+) /Cl(-) symport mechanism that involves only charged species.

81 ism for glucose/H(+) symport and discuss the symport mechanism versus facilitated diffusion.

82 irect visualization of the ion and substrate symport mechanism.

83 ide (TMG) by a permease-catalyzed sugar:H(+) symport mechanism.

84 released into the synapse in a co-transport (symport) mechanism driven by the Na(+) electrochemical g

85 Although the symport mechanisms have been well-studied, mechanisms of

86 ed in an H(+) electrochemical gradient using symport mechanisms, which are discussed herein.

87 H(2)PO(4)(-) uniport, and Cs(+)/H(2)PO(4)(-) symport mechanisms.

88 e primary driving force for the H(+)-coupled symport mediated by MelB(St).

89 ctate fluxes, is that monocarboxylate-proton symport occurs via a rapid-equilibrium ordered mechanism

90 CCs) NKCC1 and NKCC2 catalyze electroneutral symport of 1 Na(+), 1 K(+), and 2 Cl(-) across cell memb

91 a highly dynamic membrane protein, catalyzes symport of a galactopyranoside and an H(+) by using an a

92 nsmembrane helix protein LacY that catalyzes symport of a galactoside and an H(+), was studied.

93 ease (LacY) catalyzes coupled stoichiometric symport of a galactoside and an H(+).

94 (MelB) catalyzes the coupled stoichiometric symport of a galactoside with a cation (either Na(+), Li

95 of Escherichia coli catalyzes stoichiometric symport of a galactoside with an H(+), using a mechanism

96 LacY carries out the coupled stoichiometric symport of a galactoside with an H(+), using the free en

97 somal transporter that mediates H(+)-coupled symport of acidic sugars N-acetylneuraminic acid and glu

98 s (CCCs) mediate the coupled, electroneutral symport of cations with chloride across the plasma membr

99 otransporters (CCCs) catalyze electroneutral symport of Cl(-) with Na(+) and/or K(+) across membranes

100 rium (MelB(St)) catalyzes the stoichiometric symport of galactopyranoside with a cation (H(+), Li(+),

101 MelB(St) catalyzed the symport of galactosides with Na(+), Li(+), or H(+) but p

102 reviously proposed mechanisms for the linked symport of K(+) with Na(+) and H(+).

103 typhimurium (MelB-ST) catalyzes the coupled symport of melibiose and Na(+), Li(+), or H(+).

104 Salmonella typhimurium (MelB(St)) catalyzes symport of melibiose with Na(+), Li(+), or H(+), and bio

105 ica serovar Typhimurium (MelB(St)) catalyzes symport of melibiose with Na(+), Li(+), or H(+).

106 Unlike WT NIS, which mediates symport of Na(+) and the environmental pollutant perchlo

107 that couple the reuptake of substrate to the symport of one or two sodium ions.

108 mitter glutamate from synapses are driven by symport of sodium ions and counter-transport of a potass

109 should also be able to perform proton/toxin symport or uniport, leading to toxin susceptibility rath

110 of uniport and voltage-dependent H(+) /Cl(-) symport originate from strong binding to phospholipid he

111 icted to form a pseudosymmetric proton/metal symport pathway.

112 of transporters the amino acid/auxin:proton symport permeases with homology to AUX1, a putative IAA

113 tifiable physical changes in the L-fucose-H+ symport protein, FucP, from Escherichia coli, and this p

114 ficant homology to a family of metabolite/H+ symport proteins from gram-negative bacteria.

115 shed that SdcS facilitates an electroneutral symport reaction having a 2:1 cation/dicarboxylate ratio

116 m efflux by an ATP-dependent proton-ethidium symport reaction in which the carboxylate E314 is critic

117 truncated protein mediates a proton-ethidium symport reaction without the requirement for ATP.

118 cular mechanisms for H(+)- and Na(+)-coupled symport remain poorly understood.

119 egree of coupling is realized and H(+)/sugar symport represents only a specific instance.

120 t mechanism, adopting uniport and sugar/H(+) symport, respectively.

121 -)/HCO(3)(-) exchange versus Na(+)-CO(3)(2-) symport) revealed highly conserved three-dimensional org

122 access model for transport, namely, that all symported substrates must bind together before transloca

123 em to contain at least one amino acid-cation symport system that allows their cells to accumulate cer

124 in uncoupling of sugar transport from proton symport (the response).

125 ibrium exchange, which does not involve H(+) symport, the change in activation energy is much less pr

126 ntact with several amino acids essential for symport; the switch model requires allosteric interactio

127 s manner that is neither a competitive nor a symport transport.

128 rate of H322 being 100-fold faster than the symport turnover rate.

129 elease from the primary site and thus act as symport uncouplers and inhibit transport.

130 e permease (LacY) catalyzes galactoside/H(+) symport via an alternating access mechanism in which sug

131 A mechanistic model for lactose/H(+) symport via the lactose permease of Escherichia coli pro

132 itochondrial phosphate carrier (PiC, Pi/H(+) symport), which provides Pi to the matrix to sustain ATP

133 tes that coordinated activity of H(+)/solute symport with apical Na(+)/H(+) exchange optimizes the ef

134 hich are transported into the cell together (symported) with 5-HT.