ライフサイエンスコーパス: synapse

1 central regulators of actin dynamics at the synapse.

2 precision of information stored at a single synapse.

3 alpha9 subunits operates at the LL efferent synapse.

4 ation of N-glycosylated CD45 from the immune synapse.

5 ynuclein's physiological function at the pre-synapse.

6 near the presynaptic vesicle clusters at the synapse.

7 on (LTD) and potentiation (LTP) at the PF-PC synapse.

8 ghtly regulated by accessory proteins at the synapse.

9 and six resolvase dimers interact to form a synapse.

10 nAChR operates at the zebrafish LL efferent synapse.

11 esulted instead in an increase in axo-axonic synapses.

12 a direct role in re-establishing the LOC-IHC synapses.

13 ndogenous mouse tau is virtually absent from synapses.

14 plasticity is uniformly expressed across all synapses.

15 including in the formation and refinement of synapses.

16 mission and short-term plasticity in endbulb synapses.

17 o identify and functionally assay axo-axonic synapses.

18 em that delivers selected cargos to specific synapses.

19 ery rate and improves the power of detecting synapses.

20 r the maturation of developing glutamatergic synapses.

21 rted by direct data from sensory ribbon-type synapses.

22 ivaling the synaptic specificity of chemical synapses.

23 d memory impairment and a loss of underlying synapses.

24 ansmission and plasticity properties of real synapses.

25 crosstalk between excitatory and inhibitory synapses.

26 hways via Cx36 gap junctions or via chemical synapses.

27 epression (LTD) induction at hippocampal CA1 synapses.

28 of long-term potentiation (LTP) of MNTB-LSO synapses.

29 o BCs normalizes GABA release in the Fmr1-KO synapses.

30 tical gain while suppressing corticocortical synapses.

31 istribution with a finite fraction of silent synapses.

32 potentiation (LTP) at excitatory, axospinous synapses.

33 t localizes to both excitatory and GABAergic synapses.

34 s, it alters fundamental properties of these synapses.

35 accumulation of ECM proteins in contact with synapses.

36 um of vesicular release probabilities within synapses.

37 l nervous system, engulf surplus neurons and synapses.

38 but prevents synaptic plasticity only at PAG synapses.

39 revents cocaine-induced generation of silent synapses.

40 port an autocrine mode of d-serine action at synapses.

41 By contrast, Int yields only inactive synapses.

42 c plasticity at the Cornu Ammonis (CA) 3-CA1 synapses.

43 d morphological changes that occur at ribbon synapses.

44 its of mapping a mouse brain at the level of synapses.

45 kes), and (3) the stimulation of neighboring synapses.

46 creased neurotransmission at corticostriatal synapses.

47 ferior olive neurons by inhibitory GABAergic synapses.

48 e an integral part of central nervous system synapses(1,2); however, the molecular mechanisms that go

49 pes was a decreased mitochondrial content at synapses, a phenotype that paralleled with alterations o

50 rvous system, in particular at glutamatergic synapses, a potential role for Rh50 proteins at synapses

51 ty appears to arise from the total number of synapses activated by different stimuli.

52 e molecular mechanisms that govern astrocyte-synapse adhesions and how astrocyte contacts control syn

53 dvantage of the rapid advances in memristive synapses, allowing for much denser and complex neural ne

54 he use-dependent adaptation of glutamatergic synapses-along the dendritic arbor.

55 We have investigated whether synapses also adjust to life stages imposed by novel dev

56 mphocytes, MAL is found at the immunological synapse and plays a crucial role in exosome secretion.

57 D by examining miRNA processing machinery at synapse and sequencing miRNAs and analyzing their functi

58 DARs, and mGluRs are co-organized inside the synapse and their respective activation during glutamate

59 ls, where it regulates function of GABAergic synapses and assembly of RBC synaptic dyads.

60 defect resulted in excess immature neuronal synapses and behavioral abnormalities.

61 de important advances to emulate neurons and synapses and brain-computer interfacing concepts that in

62 long-term plasticity at distinct inhibitory synapses and its regulation of hippocampal network activ

63 quired to maintain NMDARs at dendritic spine synapses and mediates the direct extracellular interacti

64 GABA(A)Rs by positioning NLG-1/neuroligin at synapses and regulates the synaptic content of GABA(A)Rs

65 sprouting of new axons, the formation of new synapses and the remapping of sensory-motor functions, a

66 tamate transmission at mossy fibers (MF)-CA3 synapses, and (2) an increased number of cFos-activated

67 axo-dendritic and axo-spinous glutamatergic synapses, and intracellular labeling on the surface of m

68 postsynaptic scaffold protein in excitatory synapses, and its disruption is implicated in neurodevel

69 pulation affects translation specifically in synapses, and not at the whole-cell level.

70 moving dying neurons, pruning non-functional synapses, and producing ligands that support neuronal su

71 ) of conditioning-induced potentiation at LA synapses, and the ZIP-induced depotentiation was prevent

72 t and maintenance of functional bipolar cell synapses, and TPBG may play a similar role in RBCs.

73 tructural complexity when part of tripartite synapses, and we provide evidence that astrocytic activa

74 utes to the developmental acquisition of the synapse- and plasticity properties of PV-INs, we investi

75 sities and terminals where the sites forming synapses are connected with other neurons.

76 These results establish that silent synapses are generated by an astrocyte-mediated synaptog

77 k activity in older mice (P40-P46), when ChC synapses are inhibitory, resulted instead in an increase

78 retina in 1 week, but interneurons and their synapses are maintained for as long as 9 weeks postinduc

79 ensory epithelial cells, and those that form synapses are referred to as neuropod cells.

80 These synapses are strengthened by repeated cocaine-cue pairin

81 Chemical synapses are the main interface for transfer of informat

82 ns through a single calyx of Held excitatory synapse arising from the cochlear nucleus.

83 t mitochondrial function and localization to synapses as well as neurotransmission and synaptic plast

84 citatory transmission at hippocampal CA3-CA1 synapses, as well as suppressing hyperexcitable circuits

85 How synapses assemble remains unknown.

86 Abnormal excitatory and inhibitory synapse assembly and elevated expression of the GABAergi

87 ic adhesion protein regulating glutamatergic synapse assembly on dendrites of central neurons.

88 ve switching have provided a path to emulate synapses at the 10 nm scale, a scalable neuron analogue

89 cidence detection compared with single large synapses at the soma.

90 nt negative approach against myosin V, spine synapses became stronger compared to controls.

91 otential therapeutic strategy to protect the synapse before the development of irreversible brain dam

92 eport that spike-timing dependent LTP at the synapse between PV-INs and principal neurons of layer 4

93 verexposure to intense noise can destroy the synapses between auditory nerve fibers and their hair ce

94 Ganglion cells can form electrical synapses between dendrites of neighboring cells in suppo

95 xperience alters the number and structure of synapses between the retina and the thalamus.

96 and weakening synaptic transmission at these synapses blocks the effect of traumatic stress on aggres

97 nraveling and tension decay, which result in synapse breaking.

98 cellular membranes particularly enriched in synapses but its role in synaptic transmission remains p

99 profoundly depresses PAG and RMTg inhibitory synapses but prevents synaptic plasticity only at PAG sy

100 sin phosphorylation was attenuated within DS synapses, but enhanced in the nucleus accumbens, suggest

101 CAM overexpression also attenuated GABAergic synapses, but the effect is mediated by the loss of post

102 s leak closure in wild-type (WT), but not FX synapses, by stimulus-dependent ATP synthase beta subuni

103 We further demonstrated that the CAR synapse can be engineered to recruit either LCK to enhan

104 f inhibitory synapses relative to excitatory synapses can be tuned from weak to strong to generate a

105 We show that synapses can switch from glycolytic to oxidative metabol

106 peated mechanical bending as well as organic synapses capable of emulating a trainable and reconfigur

107 gical and morphological properties of ribbon synapses change with age remains largely unknown.

108 ls of demyelinating disease, we investigated synapse changes in the visual system.

109 e used in this context, the resulting neuron-synapse circuits require multiple transistors and compli

110 wer, but larger, individual remaining ribbon synapses colocalized with the post-synaptic afferent ter

111 Beyond these common synapse configurations are less-studied, non-canonical s

112 VN to IO synapses contain fast synaptotagmin isoforms, release ne

113 Climbing-fiber synapses, conversely, were unaffected.

114 nization during the recovery period in which synapse counts recover from 16 to 91% of normal in the m

115 endritic spine nano-architecture, and single-synapse currents, evaluated using two-photon glutamate u

116 Similar to chemical synapses, Cx36-containing gap junctions undergo activity

117 tudies suggest that Abeta drives neurite and synapse degeneration through an array of tau-dependent a

118 gic (VGlut1 and VGlut2) and GABAergic (VGAT) synapses demonstrated that overall synaptic patterns rem

119 striatum and thalamus showed a wide range of synapse densities.

120 The encoding efficacy of this large synapse depends on its activity rate, which is primarily

121 We conclude that NPTX2 is a promising synapse-derived disease progression biomarker in genetic

122 present an automatic probability-principled synapse detection algorithm and integrate it into our sy

123 However, how these proteins regulate synapse development and presynaptic function in a develo

124 l mode by which neuroligin splicing controls synapse development through protein-glycan interaction a

125 mportant for axon guidance, innate immunity, synapse development, and synaptic plasticity.

126 e phenomenon occurs at conventional neuronal synapses due to the difficulties in collecting such data

127 to influence both excitatory and inhibitory synapses during development can potentially contribute t

128 to influence both excitatory and inhibitory synapses during development can potentially contribute t

129 Synapse dysfunction is emerging as an early pathological

130 neuroglia, resulting in complement-mediated synapse elimination in AD models.

131 been shown to be required for developmental synapse elimination in the mouse visual thalamus as well

132 glial activation and complement C3-dependent synapse elimination in vivo.

133 nhibitor that regulates complement-dependent synapse elimination.

134 would also be abnormal without C1q-mediated synapse elimination.

135 , within the cleft of two different neuronal synapses encourages a reassessment of the scope of activ

136 ive inputs appears to be reserved for weaker synapses, enhancing the contribution of weak synapses to

137 hyperpolarization component of spikelets (a synapse-evoked action potential passively propagating fr

138 Functionally distinct synapses exhibit diverse and complex organisation at mol

139 uscular junction (NMJ) has long been a model synapse for the study of neurotransmission, its presynap

140 eural development by powerfully coordinating synapse formation and function and, as such, may be crit

141 adhesions and how astrocyte contacts control synapse formation and function are largely unknown.

142 postnatal day (P) 14-28 period would affect synapse formation and maturation in the developing hippo

143 termine how the extracellular matrix directs synapse formation and regulates synaptic function in a m

144 re synaptic adhesion molecules with roles in synapse formation and signaling.

145 Immunological synapse formation between cytotoxic T lymphocytes (CTLs)

146 While the cellular processes underlying synapse formation have been well characterized, those th

147 The synaptotrophic hypothesis posits that synapse formation stabilizes dendritic branches, but thi

148 ion of common genetic factors that drive the synapse formation within these subgraphs.

149 Synapse formation, maturation, and turnover require a fi

150 After axon outgrowth and synapse formation, the nervous system transitions to a s

151 Ps, singly or in combination, in mice before synapse formation.

152 their segregation, dendritic outgrowth, and synapse formation.

153 in early activation events in NK cell lytic synapse formation.

154 is a fast-acting antidepressant and induces synapse formation.

155 on and infantile memory, indicating that the synapse formation/maturation is necessary for creating i

156 Here, an organic memristive synapse formed of monochloro copper phthalocyanine, whic

157 g and degradation is especially important in synapses formed between cells, which create signaling 'n

158 Synapses from each inhibitory population change accordin

159 Here, we show that inhibitory synapses from parvalbumin and somatostatin expressing in

160 Synapses from the posterior medial thalamic nucleus to e

161 and local interneurons while also receiving synapses from the retina.

162 h presynaptic neurexins (NRXNs) and regulate synapse function.

163 th non-invasive stimulation targeting spinal synapses further promotes functional recovery.

164 ew ephaptic coupling, in which an excitatory synapse generated large negative extracellular signals t

165 determines the ultrafast kinetics of endbulb synapses glutamatergic currents by promoting the inserti

166 ere, we examine how Drosophila neuromuscular synapses grow to match the size of their target muscles.

167 autonomous muscle growth and non-autonomous synapse growth.

168 apses, a potential role for Rh50 proteins at synapses has not yet been investigated.

169 Optoelectronic synapses hold the special potential of integrating these

170 At excitatory synapses, how endogenous AMPARs, NMDARs, and mGluRs are

171 ands by dynamically changing the gain of its synapses; however, some tasks require ongoing linear tra

172 rexins perform a major function at the calyx synapse in coupling presynaptic calcium channels to rele

173 role of miRNAs and their functioning at the synapse in MDD by examining miRNA processing machinery a

174 ecruitment of GABA(A) receptors at GABAergic synapses in C. elegans The interaction of N-MADD-4B with

175 ty at parallel fibre (PF)-Purkinje cell (PC) synapses in cerebellar cortex.

176 Severe loss of excitatory synapses in key brain regions is thought to be one of th

177 K-1.1 forms phase-separated condensates near synapses in response to energy stress from transient hyp

178 c chains are underappreciated in neurons and synapses in the brain.

179 ative roles of glutamatergic and cholinergic synapses in the induction of LTP to be distinguished.

180 We found the highest densities of synapses in the isocortex, olfactory areas, hippocampal

181 antitative map of the features of excitatory synapses in the lumbar spinal cord, detailing synaptic d

182 outer plexiform layer and increased ectopic synapses in the outer nuclear layer compared to controls

183 tant animals have significantly fewer ribbon synapses in the outer plexiform layer and increased ecto

184 smitter release is a fundamental property of synapses in which neurotransmitter filled vesicles relea

185 roligin-2, a key component of the inhibitory synapse, in the NAc that modifies behavioral coping mech

186 does not influence transmission at PC-to-DCN synapses, indicating that conclusions based on studies o

187 density or ultrastructure of corticostriatal synapses, indicating that the observed functional defect

188 ry for the expression of LTP at PV-IN output synapses, involving gene expression programs that need t

189 propose that the receptor at the LL efferent synapse is a alpha9alpha10 nicotinic acetylcholine recep

190 We conclude that the Tn3/Bart family synapse is assembled exclusively by R interactions betwe

191 These results suggest that the MOC-OHC synapse is immature at the onset of hearing.SIGNIFICANCE

192 on in which the z intensity profile for each synapse is modelled as a Moffat function.

193 rolling unmodified serotonin levels in brain synapses is a primary objective when treating major depr

194 lasticity at thalamo-lateral amygdala (T-LA) synapses is critically involved in the regulation of coc

195 ing runaway potentiation of individual spine synapses, keeping most of them at an intermediate streng

196 ond goosebumps, muscle-anchored nerves form "synapse-like" connections with hair follicle stem cells

197 vely diminished the ongoing microgliosis and synapse loss in AD models.

198 cal traits include reduced axonal transport, synapse loss, defective climbing ability and olfactory p

199 transnitrosylation reactions contributes to synapse loss, the major pathological correlate to cognit

200 pression, F-actin accumulation at the immune synapse, lytic granule trafficking, and cytotoxicity.

201 currently not known, it has been shown that synapses made between MLIs and Purkinje cells exhibit lo

202 lar and axonal navigation also play roles in synapse maturation and homeostasis.

203 acid (TCA) cycle enzyme levels, and triggers synapse maturation.

204 Therefore, we hypothesized that inhibitory synapses may have different organizing principles.

205 pening and closing, respectively, the silent synapse-mediated destabilization window.

206 dry-responsive VP PNs, meaning that just two synapses might separate hygrosensory inputs from motor c

207 that in addition to excitatory glutamatergic synapses, MOC neurons receive inhibitory GABAergic and g

208 trol attack duration, whereas the MeApv-BNST synapses modulate attack frequency, both with no effect

209 reduced cell viability, whereas ICM reduced synapse number independent of changes in cell viability.

210 PX2(-/Y) mice show decreased thalamocortical synapse numbers and increased spine pruning.

211 stereotyped, but not identical, in cell and synapse numbers between brain hemispheres.

212 We show that the auditory synapse of GLAST KO mice is more vulnerable to cisplatin

213 Tau enriched in the synapse of line 66 mice, therefore, appears to be in an

214 Natural tree structures displayed by synapses of the brain involves potentiation and depressi

215 receptor (A1R) activation at corticostriatal synapses of the direct pathway [cortico-striatal project

216 exin-36-containing glutamatergic mossy fiber synapses of the rat hippocampus express previously unrec

217 ortex arrive at corticospinal-motor neuronal synapses of upper- or lower-limb muscles (depending on t

218 hair cell force to the inner hair cells that synapse on afferent nerves.

219 we find that LRRTM4 is enriched at GABAergic synapses on axon terminals of rod bipolar cells (RBCs).

220 behavioral distinctions, all ~15 individual synapses on each muscle cell are shared by a 1 degrees M

221 eir terminals form excitatory, glutamatergic synapses on host cortical neurons.

222 thorough evaluation of dendritic spines and synapses on pathway-identified SPNs.

223 by abstinence selectively potentiates their synapses on targets that encode aversion.

224 eus of the hypothalamus (PVN) that appear to synapse onto vasopressin-synthesizing neurons.

225 nts established that the number of GABAergic synapses onto abDGCs increased with maturation, whereas

226 ddress this issue, we studied auditory nerve synapses onto bushy cells in the cochlear nucleus of mic

227 firms MNTB neurons as a source of inhibitory synapses onto MOC neurons.

228 We provide evidence that Syt2a localizes to synapses onto neurons implicated in social behavior in t

229 that the AON forms glutamatergic excitatory synapses onto piriform pyramidal neurons; and while thes

230 lly-coupled neurons that make climbing fiber synapses onto Purkinje cells.

231 -distance indirect projections (two to three synapses) onto the main olfactory bulb (MOB).

232 tatory-inhibitory balance is defined at most synapses or about the mechanisms for establishing or mai

233 axon initial segment, in the axon shaft, at synapses or in growth cones.

234 LRRTM4 is thus a key synapse organizing molecule at RBC terminals, where it r

235 Astrocyte dysfunctions are also linked to synapse pathologies associated with neurodevelopmental d

236 Glycinergic synapses play a central role in motor control and pain p

237 At hearing onset, the MOC-OHC synapse presented facilitation during MOC fibers high-fr

238 uctance-update characteristics of artificial synapses prevent a hardware neural-network from deliveri

239 These defects coincided with altered synapse protein organization, and horizontal cell neurit

240 al cell neurites were misdirected to ectopic synapse protein regions.

241 bidirectional interaction between sleep and synapse pruning after antennal injury: locally increasin

242 etection algorithm and integrate it into our synapse quantification tool SynQuant.

243 ntigen-presenting cell form an immunological synapse, rapid dynein-driven translocation of the centro

244 We show that the strength of inhibitory synapses relative to excitatory synapses can be tuned fr

245 e symmetry, and thereby the stability of the synapse, remain unknown.

246 Furthermore, we find that the MeApv-VmH synapses selectively control attack duration, whereas th

247 Interestingly, synapse signaling-associated gene signatures (such as sy

248 previous intracellular observations in these synapses.SIGNIFICANCE STATEMENT Although synaptic dynami

249 ria functional integrity and localization to synapses.SIGNIFICANCE STATEMENT Menkes and Wilson diseas

250 At the phagocytic synapse, SIRPA inhibited integrin activation to limit ma

251 l activity, in synaptic vesicle dynamics, in synapse size, and in synaptic mRNA amounts.

252 1 anterograde transneuronal spread is highly synapse specific.

253 (2020) reveal that the synapse-specific breakdown of endocannabinoid signaling

254 n for high-spontaneous-rate ANFs, implying a synapse-specific contribution to lowpass filtering.

255 We integrate findings pertaining to synapse structure and morphology, neurotransmission, pos

256 ld Ca(V)2s to presynaptic release sites, and synapse structure is Ca(V)2 independent.

257 are two competing models for their roles in synapse structure.

258 We previously identified thalamo-amygdala synapses (T-LA) that project via the interal capsule, as

259 usually involve some partners receiving more synapses than others.

260 euromuscular junction (NMJ) is a specialized synapse that is the point of connection between motor ne

261 intensity fluctuations in structures such as synapses that are small compared to the axial point-spre

262 inals instead of output neuron Purkinje cell synapses that dominate the adult cerebellum.

263 etric dimer in which the two central domains synapse the ends while two C-terminal domains form a sep

264 the integrity and full functionality of this synapse, the contribution of this structure as a primary

265 ation of GABA(A)R accumulation at inhibitory synapses, thereby regulating the strength of synaptic in

266 h factors impact the diversity of excitatory synapses throughout the lumbar spinal cord.

267 Astrocytic glial cells interact with synapses throughout the whole brain and are recognized a

268 autophagy in neurons, from biogenesis at the synapse to degradation in the soma.

269 uch mesophasic self-organization might allow synapses to achieve a 'Goldilocks' state, striking a bal

270 ed across a range of scales, from individual synapses to circuit pathways.

271 synapses, enhancing the contribution of weak synapses to somatic responses.

272 CG) at the target cell interface, the immune synapse, to kill virus-infected and tumorigenic target c

273 put provides a signal to parallel fiber (PF) synapses, triggering PF synaptic plasticity.

274 nfigurations are less-studied, non-canonical synapse types that are prevalent throughout the brain an

275 ells do not necessarily generalize to mature synapses under physiological conditions.

276 These synapses undergo bidirectional presynaptic and postsynap

277 ircuit models with non-identical neurons and synapses underlying rhythmic behavior, we analyzed the c

278 independent inhibitory currents at GABAergic synapses, using (+)-bilobalide as a negative control.

279 itment and strengthening of GABA(A) receptor synapses via Ca(2+)/calmodulin-dependent protein kinase

280 The loss of afferent synapses was present in all strains at 15 months.

281 cle exocytosis at cultured mouse hippocampal synapses, we induced single action potentials by electri

282 The axial profiles of ROIs corresponding to synapses were described using a Moffat function and this

283 Using this technology, 24,752 synapses were fully reconstructed in CA1, revealing that

284 Afferent synapses were lost from inner hair cells throughout the

285 erived Purkinje cells (hPSC-PCs) that formed synapses when cultured with mouse cerebellar glia and gr

286 G granule cell dendritic arbors, spines, and synapses, whereas it restricts the survival of adult-bor

287 crosstalk between excitatory and inhibitory synapses whereby Ca(2+)-entering through postsynaptic NM

288 intercellular junctions termed immunological synapses which facilitate exchange of crucial biochemica

289 ty guides the strengthening and silencing of synapses which underlies tonotopic map refinement.

290 platin, less is known regarding the afferent synapse, which is an essential component in the faithful

291 s express previously unrecognized electrical synapses, which are normally silent.

292 ers an increase in the density of inhibitory synapses, which is accompanied by enhanced axonaloutgrow

293 e a reduction of BRI2 levels and function at synapses, which results in reduced glutamatergic transmi

294 arger fraction of their neighbors and create synapses with a greater proportion of their neighbors.

295 is currently being made to mimic neurons and synapses with hardware components, an approach known as

296 ation, AII ACs maintain a constant number of synapses with RGCs, preferentially increase synaptogenes

297 rease synaptogenesis with BCs, and eliminate synapses with wide-field amacrine cells.

298 buted connectivity in the LH, preferentially synapsing with principal neuron types based on transmitt

299 n geometries representative of extracellular synapses, within which we localize the nucleotidases.

300 illover of glutamate onto nearby glycinergic synapses would permit rapid crosstalk between excitatory