ライフサイエンスコーパス: synapse formation

1 their segregation, dendritic outgrowth, and synapse formation.

2 ent binding of both ligands is necessary for synapse formation.

3 t disrupting DIP function results in ectopic synapse formation.

4 in early activation events in NK cell lytic synapse formation.

5 roles of Celsr3 and Vangl2 in glutamatergic synapse formation.

6 instructive role of intrinsic mechanisms in synapse formation.

7 ule play a key role in the efficiency of the synapse formation.

8 ion and its role in dendritic maturation and synapse formation.

9 xin-1, Munc18-1, and/or SNAP-25, well before synapse formation.

10 trate that is required for MT3-MMP-dependent synapse formation.

11 is a fast-acting antidepressant and induces synapse formation.

12 ribute to Sonic hedgehog (Shh) signaling and synapse formation.

13 ein, RTN3, a reticulon protein implicated in synapse formation.

14 ng RNA topoisomerase reaction, and promoting synapse formation.

15 cts in vertebrate motoneuron development and synapse formation.

16 ogenic thrombospondin 1 (TSP-1) release, and synapse formation.

17 aberrant neurite outgrowth and glutamatergic synapse formation.

18 is a critical and poorly understood step in synapse formation.

19 a and Ank2 are targeted to prevent excessive synapse formation.

20 axon trajectories, synaptic specificity, and synapse formation.

21 brain, such as in dendritic arborization and synapse formation.

22 onal growth and impaired dendritic spine and synapse formation.

23 ic adhesion molecules play critical roles in synapse formation.

24 F186) expressed in the PC AIS during pinceau synapse formation.

25 c targets initiates the process of GABAergic synapse formation.

26 at the HIV Env did not disrupt immunological synapse formation.

27 organization of BC axon and impairs pinceau synapse formation.

28 underscoring the importance of FGF-dependent synapse formation.

29 ed the enhancement of PA learning and silent synapse formation.

30 ntified two new genes involved in electrical-synapse formation.

31 sites, where it promotes dendritic spine and synapse formation.

32 is required for both electrical and chemical synapse formation.

33 contact the plasma membrane directly during synapse formation.

34 gions, stimulate axonal pruning, and inhibit synapse formation.

35 aling, cytoskeletal organization, and immune synapse formation.

36 es drive polarity in both cell migration and synapse formation.

37 onset of remodeling and are critical for new synapse formation.

38 on during fever contributes to immunological synapse formation.

39 dNK, and may represent the initial stage of synapse formation.

40 cytoskeleton to regulate neuronal growth and synapse formation.

41 without changing neuronal differentiation or synapse formation.

42 neuronal differentiation, axon guidance and synapse formation.

43 D1; postsynaptic) were explored for chemical synapse formation.

44 anism distinct from conventional virological synapse formation.

45 esting that Tim-3 plays a functional role in synapse formation.

46 of purified hyaluronan suppresses excitatory synapse formation.

47 s suggest that each plays a distinct role in synapse formation.

48 y synapses, while also decreasing inhibitory synapse formation.

49 promote neuronal ion channel maturation and synapse formation.

50 l changes that initiate spine and excitatory synapse formation.

51 d throughout the periphery of T-cells during synapse formation.

52 , forming trans-synaptic triads that promote synapse formation.

53 additional ligands to orchestrate excitatory synapse formation.

54 uPA/uPAR binding triggers axonal growth and synapse formation.

55 to morphogenesis, cellular excitability, and synapse formation.

56 on and impairs excitatory but not inhibitory synapse formation.

57 fic miRNAs have been identified that control synapse formation.

58 heir knockdown impairs spine development and synapse formation.

59 Ps, singly or in combination, in mice before synapse formation.

60 egulates targeted axon growth and inhibitory synapse formation.

61 ce the sprouting response, arborization, and synapse formation.

62 ights into the dynamic process of inhibitory synapse formation.

63 ion, filopodial destabilization, and reduced synapse formation.

64 abundance and are involved in glutamatergic synapse formation.

65 s involving migration, arbor remodeling, and synapse formation.

66 al neurons, as well as abnormal dendrite and synapse formation.

67 f laminar structure, motor coordination, and synapse formation.

68 naling molecule that, among others, enhances synapse formation.

69 cule Semaphorin4D (Sema4D) during inhibitory synapse formation.

70 en WASp activation, F-actin assembly, immune synapse formation, actin foci formation, mechanotransduc

71 ing spatial constraints, Kon/Koff rates, and synapse formation, along with in-depth analysis of CAR s

72 o modify its output by way of an increase in synapse formation and a decrease in synaptic release eff

73 at nascent presynaptic sites initiates both synapse formation and axon branching.

74 hology 1 (RPM-1) is a conserved regulator of synapse formation and axon termination in Caenorhabditis

75 h the Cb(R290H) mutation perturbs inhibitory synapse formation and causes brain dysfunction.

76 nomously in the postsynaptic neuron for both synapse formation and dendritic arborization.

77 ping central nervous system, the dynamics of synapse formation and elimination are insufficiently und

78 tact-mediated glial-neuronal interactions in synapse formation and elimination during development is

79 pearance of dendritic spines, accompanied by synapse formation and elimination may underlie the exper

80 Astrocytes are implicated in synapse formation and elimination, which are associated

81 t assembly requires the fine balance between synapse formation and elimination.

82 thic pain states through abnormal excitatory synapse formation and enhanced presynaptic excitatory ne

83 he structure and function of synapses during synapse formation and experience-dependent synaptic plas

84 eural development by powerfully coordinating synapse formation and function and, as such, may be crit

85 adhesions and how astrocyte contacts control synapse formation and function are largely unknown.

86 Astrocytes are critical for regulating synapse formation and function as well as metabolic supp

87 pecialized anatomical structures, defects in synapse formation and function can often be observed as

88 factors that work synergistically to enhance synapse formation and function, and support neuronal gro

89 integral partners with neurons in regulating synapse formation and function, but the mechanisms that

90 strates the requirement of SPAG6 for optimal synapse formation and function, its direct role in immun

91 in development, including neurite outgrowth, synapse formation and function, long-term and homeostati

92 al about the molecules that support chemical synapse formation and function, we know little about the

93 as a novel deafness gene required for ribbon synapse formation and function, which is critical for so

94 or extracellular matrix proteins in boosting synapse formation and function.

95 and reveal how astrocytes control GABAergic synapse formation and function.

96 f regulators of neuronal differentiation and synapse formation and function.

97 al differentiation and apoptosis, as well as synapse formation and function.

98 15) define the early events of immunological synapse formation and granule release.

99 Synapse formation and growth are tightly controlled proc

100 cells in the central nervous system, promote synapse formation and help to refine neural connectivity

101 Expressing STB-R178Q fails to rescue reduced synapse formation and impaired synaptic transmission and

102 corticospinal axon regeneration, functional synapse formation and improved skilled forelimb function

103 the CD4 T cell immunological synapse affects synapse formation and intracellular signaling to impact

104 -45A is disposable for NK cell immunological synapse formation and lytic granules reorientation but c

105 s a key role in promoting learning-dependent synapse formation and maintenance on selected dendritic

106 MDAR subunits in the brain and may influence synapse formation and maintenance.

107 , indicating its essential role in GABAergic synapse formation and maintenance.

108 important in signal transduction, as well as synapse formation and maintenance.

109 lt nervous system and a crucial regulator of synapse formation and maturation during post-injury remo

110 al knock-outs, we found excessive excitatory synapse formation and maturation in the cortices of P21

111 postnatal day (P) 14-28 period would affect synapse formation and maturation in the developing hippo

112 e-dependent calcium channels that also drive synapse formation and maturation.

113 t developmental origins influence fine-scale synapse formation and microcircuit assembly of neocortic

114 restored CD8 T-cell cytotoxicity and immune synapse formation and normalized T-cell cytokines and pr

115 Importantly, the convergent effects on synapse formation and plasticity also reverse the well-d

116 Synapse formation and plasticity depend on nuclear trans

117 ncodes the protein menin, is known to induce synapse formation and plasticity in the CNS.

118 ival and metabolism, neuronal morphogenesis, synapse formation and plasticity, and learning and memor

119 e-B (TrkB) to regulate neuronal development, synapse formation and plasticity.

120 and astrocytes perform critical functions in synapse formation and refinement in the developing brain

121 termine how the extracellular matrix directs synapse formation and regulates synaptic function in a m

122 nin signaling pathway promotes neurogenesis (synapse formation and remodeling) and inhibits neurodege

123 underlying activity-dependent Sema4D-induced synapse formation and reveal a novel role for presynapti

124 nsitive to Sema4D at a specific stage during synapse formation and sensitivity to Sema4D is regulated

125 prising link between electrical and chemical synapse formation and show that Nbea acts as a critical

126 re synaptic adhesion molecules with roles in synapse formation and signaling.

127 65 (Np65) highly expressed during periods of synapse formation and stabilization is present at the pr

128 t of excitatory synapses and plays a role in synapse formation and stabilization.

129 Mef2c suppresses corticostriatal synapse formation and striatal spinogenesis, but can its

130 paired mitochondrial function, arborization, synapse formation and synaptic GABA release.

131 sults suggest that the influence of menin on synapse formation and synaptic plasticity occur via modu

132 hesion molecules (SAMs) due to its impact on synapse formation and synaptic plasticity.

133 This disruption in synapse formation and synaptic transmission by SMN defic

134 In motoneuron-astrocyte contact cocultures, synapse formation and synaptic transmission were signifi

135 tem, have general roles in the modulation of synapse formation and synaptic transmission, blood-brain

136 ted normal survival but intrinsic defects in synapse formation and synaptic transmission.

137 sion molecules that are essential for normal synapse formation and synaptic transmission.

138 tory synapses, where it critically regulates synapse formation and the resulting balance between exci

139 mpacts the ratio of excitatory to inhibitory synapse formation and the resulting neural activity.

140 ppocampal neurons respond and integrate into synapse formation and transmission in cultured neuronal

141 developmental switch from axon elongation to synapse formation and transmission that doubles as a sup

142 elium, late viral proteins orchestrate viral synapse formation and viral transfer to the contact cell

143 eneurin may directly or indirectly influence synapse formation and/or maintenance.

144 This cascade acts during development (synapse formation) and ageing (synapse maintenance) alik

145 , receptor expression, proliferation, immune synapse formation, and cytokine signaling.

146 oting neuronal survival, inducing functional synapse formation, and engulfing synaptosomes.

147 ears of life, based on anatomical studies of synapse formation, and establishment of intracortical an

148 s controlling BCR organization during immune synapse formation, and how this impacts BCR signaling, a

149 rf1, thereby impairing actin polymerization, synapse formation, and immune cell migration.

150 y "exhausted" T cells, defective immunologic synapse formation, and immunosuppressive myeloid cells.

151 mechanism for continued circuit plasticity, synapse formation, and integration of new neurons in the

152 lved in Alzheimer's disease, plays a role in synapse formation, and is upregulated in intellectual di

153 anges in genes associated with neurogenesis, synapse formation, and neuronal cell death.

154 role in leukocyte trafficking, immunological synapse formation, and numerous cellular immune response

155 Wnts are known regulators of synapse formation, and our data reveal that Wnt5a inhibi

156 s important for normal neuronal development, synapse formation, and proper propagation of action pote

157 cytes can eliminate dendritic spines, induce synapse formation, and regulate neurotransmission and pl

158 glial cocultures from KCNH2-3.1 mice impairs synapse formation, and replenishing reduced CFH gene exp

159 ction of rapsyn and a role of neddylation in synapse formation, and reveals a potential target of the

160 ble ways in which neurotransmitter may drive synapse formation, and speculate on how the environment

161 uld underlie the repression of inappropriate synapse formation, and suggest mechanistic similarities

162 tivity by increasing dendritic arborization, synapse formation, and synaptic transmission.

163 ease-associated Kirrel3 missense variants on synapse formation, and thereby, increases understanding

164 ith an RNA-binding protein, FMRP, to promote synapse formation; and Top3beta gene deletion has been l

165 Axon pathfinding and synapse formation are essential processes for nervous sy

166 he molecular processes underlying inhibitory synapse formation are not well understood.

167 Axonal branching and synapse formation are tightly linked developmental event

168 rise to mossy fibers--and promotes GABAergic synapse formation as a result of release from axons.

169 emonstrate Kirrel3 regulates target-specific synapse formation at hippocampal mossy fiber (MF) synaps

170 initial RAG binding events and characterize synapse formation at the single-molecule level, yielding

171 gulators of neuronal development function in synapse formation, axon guidance, and axon termination.

172 shapes bipolar-->ganglion cell glutamatergic synapse formation, beginning around the time of eye-open

173 Immunological synapse formation between cytotoxic T lymphocytes (CTLs)

174 inhibit Zap70 catalytic activity we examined synapse formation between cytotoxic T lymphocytes and th

175 t auditory fiber activity has stimulated the synapse formation between fast-spiking parvalbumin posit

176 l steps, the molecular mechanisms underlying synapse formation between group Ia proprioceptive sensor

177 Synapse formation between implanted and host neurons was

178 We believe immune synapse formation between MCs and gammadelta T cells is

179 hyperactivity and attention by inducing new synapse formation between neurons.

180 relates to a coordinated inhibitory chemical synapse formation between sparsely labelled interneurons

181 LFA-1, a critical molecule for immunological synapse formation between T cells and APCs, and for cyto

182 synaptic proteins likely affect not only on synapse formation but also on ongoing synaptic function.

183 cal modifications, including myelination and synapse formation, but also pruning of aberrant connecti

184 Thus, LAR-RPTPs are not essential for synapse formation, but control synapse properties by reg

185 ell adhesion molecules is thought to mediate synapse formation, but the mechanisms involved remain el

186 raising the question of how SPARCL1 enhances synapse formation by binding to these molecules.

187 e axonal transport of synaptic materials and synapse formation by controlling the nucleotide state of

188 Synapse formation by each hair cell of the zebrafish's l

189 ding of mechanisms mediating target-specific synapse formation by providing evidence that Kirrel3 tra

190 postsynaptic latrophilins promote excitatory synapse formation by simultaneous binding of two unrelat

191 functions of Rem2 in neurons: regulation of synapse formation, dendritic morphology, and voltage-gat

192 Excitatory synapse formation during development involves the comple

193 e report impairments in dendritic growth and synapse formation early on during Purkinje cell developm

194 This increased excitatory synapse formation elevates network activity, as demonstr

195 ities afforded to Int(E499K) in reattempting synapse formation enhances the probability of success at

196 remains unclear, as does the extent to which synapse formation enhances the stability of newly formed

197 tein(s) orchestrates T cell polarization and synapse formation, followed by anterograde dynein-mediat

198 ics and a data-driven computational model of synapse formation for R7 photoreceptor axons in developi

199 vide neurotrophic support; are implicated in synapse formation, function, and pruning; and help maint

200 While many molecules impact synapse formation generally, we know little about molecu

201 While the cellular processes underlying synapse formation have been well characterized, those th

202 onal transport of presynaptic components for synapse formation, however, remain unclear.

203 hat are thought to contribute to early spine synapse formation; however, the actin regulatory protein

204 d knockdown of spinophilin hinders spine and synapse formation in Asef2-expressing neurons.

205 aberrant dendrite development and defective synapse formation in CA1 neurons.

206 neuroligins are generally not essential for synapse formation in CA1 pyramidal neurons but shape syn

207 ata indicate, for first time, that GABAergic synapse formation in corticostriatal pairs depends on tw

208 h target and non-target motor neurons during synapse formation in culture.

209 of growth cone dynamics from axon growth to synapse formation in cultured Drosophila brains.

210 icate that it is not required for structural synapse formation in dentate granule cells or for Shh-de

211 lexinA2 interactions that inhibit excitatory synapse formation in developmentally born and adult-born

212 NgR1 is sufficient to accelerate excitatory synapse formation in dissociated cortical neurons and in

213 , axonal targeting, dendritic branching, and synapse formation in Drosophila, novel features related

214 mitochondrial development, neurogenesis and synapse formation in hiPSCs-derived cortical neurons.

215 Both myostatin and GDF11 affected synapse formation in isolated rat cortical neuron cultur

216 Cdc42 in presynaptic neurons is required for synapse formation in monosynaptic sensory-motor circuits

217 , we show that the Rho GTPase Cdc42 controls synapse formation in monosynaptic sensory-motor connecti

218 s antigen receptor signaling in lymphocytes, synapse formation in neurons, and bacterial adhesion to

219 to visualize differential allogeneic immune synapse formation in polyclonal CD4(+) T cells using hig

220 1, a secreted non-neuronal protein, promotes synapse formation in rodent and human neurons.

221 Improper synapse formation in Spag6KO mice was associated with de

222 ts in considerable HOA-AVG fasciculation and synapse formation in the absence of the other two.

223 nd unravel a distinct architectural rule for synapse formation in the adult brain.

224 ubiquitin-signaling network that suppresses synapse formation in the brain.

225 An important component of synapse formation in the cochlea is a process of SGN "de

226 deficit to impaired myelination and aberrant synapse formation in the cochlea, which manifest during

227 n regulates activity-dependent glutamatergic synapse formation in the developing striatum.

228 ptic sensory neurons is essential for proper synapse formation in the development of monosynaptic sen

229 tanding of precise excitatory and inhibitory synapse formation in the mammalian brain.

230 Despite their apparent behavioral rescue, synapse formation in these fish was significantly altere

231 ons, but the molecular mechanisms underlying synapse formation in these monosynaptic sensory-motor co

232 observed for APLP1, is essential for proper synapse formation in vitro and synapse maintenance in vi

233 C. elegans SYG-1's specification of proper synapse formation in vivo closely correlates with the he

234 xact temporal relationship between spine and synapse formation in vivo remains unclear, as does the e

235 Here we find that electrical synapse formation in vivo requires an intracellular scaf

236 Despite these differences, neuromuscular synapse formation in zebrafish and mice share similar me

237 t, suggest a second mode in which cumulative synapse formation inhibits further dendrite growth, and

238 Synapse formation is a process tightly controlled in spa

239 talytic activity Vav-1 activation occurs and synapse formation is arrested at a stage with actin and

240 In gon-1 mutants, once synapse formation is complete, motor neuron presynaptic

241 Synapse formation is comprised of target cell recognitio

242 A key factor expressed early in synapse formation is Msp300/Nesprin-1, which organizes a

243 isms specify spatial and temporal aspects of synapse formation is not well understood.

244 Proper synapse formation is pivotal for all nervous system func

245 ted neurons are positioned in the volume and synapse formation is restricted to biological bouton den

246 le research suggests that the specificity of synapse formation is supported by complex intercellular

247 an CD4(+) T cells, and, during immunological synapse formation, it transiently redistributed to the T

248 building that it also drives the process of synapse formation itself.

249 s that at the initial stage of immunological synapse formation, LZTFL1 is concentrated at the APC con

250 GF-1) pathway as well as pathways related to synapse formation, maintenance and neuronal differentiat

251 e mechanism described here likely applies to synapse formation, maintenance, and function in multiple

252 ells are emerging as important regulators of synapse formation, maturation, and plasticity through th

253 Synapse formation, maturation, and turnover require a fi

254 on and infantile memory, indicating that the synapse formation/maturation is necessary for creating i

255 Our live data support a "serial synapse formation" model, where at any time point only 1

256 Thus two major aspects of synapse formation, morphological plasticity and subtype-

257 ockout mice to in vitro analyses of impaired synapse formation, morphology, and aberrant neuronal exc

258 issue repair and regeneration by stimulating synapse formation, neurite outgrowth, and neuronal survi

259 ays involved in brain development, including synapse formation, neuron differentiation, cell adhesion

260 ed for microcluster formation, immunological synapse formation, nor actin remodeling following CAR ac

261 d to axon guidance (associated with SEMA6D), synapse formation (NTNG1), and neuronal specification (H

262 Synapse formation occurred through clustered growth of a

263 pre and postsynaptic neurons that accompany synapse formation often temporally and spatially overlap

264 rganizing synapses but are not essential for synapse formation or maintenance.

265 trans-neuronal interaction processes such as synapse formation or maintenance.

266 Absence of Pyk2 has no major effect on synapse formation or the basal parameters of synaptic tr

267 ic questions extending from axonal guidance, synapse formation, or axonal transport to the developmen

268 ct subcellular domains that locally regulate synapse formation, or by axon guidance cues restricting

269 tal alteration in dendritic arborization and synapse formation, our findings provide new insights int

270 Given the key roles of astrocytes in synapse formation, plasticity, and function, we sought t

271 this cross-dressed MHC can assist in immune synapse formation prior to the induction of full T cell

272 understanding of the molecular mechanisms in synapse formation provides insight into both learning an

273 typic wiring patterns by promoting selective synapse formation rather than elimination.

274 Functional synapse formation requires tight coordination between pr

275 pecifically promote excitatory or inhibitory synapse formation, respectively.

276 We find that WT Kirrel3 induces synapse formation selectively between Kirrel3-expressing

277 systems that play key roles in immunological synapse formation, shear-dependent thrombus formation, a

278 uggest that they do not play a major role in synapse formation.SIGNIFICANCE STATEMENT Human neuroligi

279 Excitatory spine synapse formation (spinogenesis) is a poorly understood

280 The synaptotrophic hypothesis posits that synapse formation stabilizes dendritic branches, but thi

281 g and cell aggregation, but failed to induce synapse formation, suggesting that IgSF9 acts as a cell

282 domain or catalytic residue fail to promote synapse formation, suggesting that Top3beta requires bot

283 n synaptic function and as key regulators of synapse formation, synaptic activity, plasticity, and sy

284 protein of postsynaptic density involved in synapse formation, synaptic plasticity, and synaptic tar

285 l process that more closely resembles immune synapse formation than it does conventional chemotaxis.

286 After axon outgrowth and synapse formation, the nervous system transitions to a s

287 iverse physiological functions, ranging from synapse formation to formation of the kidney filtration

288 NK cell lytic granule trafficking and immune synapse formation to trigger apoptosis of targeted cells

289 entially disrupting neuronal development and synapse formation, ultimately leading to ASD.

290 ic-independent mechanism, controls GABAergic synapse formation via trans-synaptic interactions mediat

291 ty for T-cell activation and superior immune synapse formation when compared with paired peripheral b

292 rophilins (LPHNs/ADGRLs) promotes excitatory synapse formation when LPHNs simultaneously interact wit

293 dogenous Asef2 with shRNAs impairs spine and synapse formation, whereas exogenous expression of Asef2

294 urin or FLRT alone did not induce excitatory synapse formation, whereas together they potently did so

295 Neural circuit wiring relies on selective synapse formation whereby a presynaptic release apparatu

296 activities were required for input-specific synapse formation, which suggests that coincident bindin

297 ial metabolism and network, neurogenesis and synapse formation, while Mfn2 overexpression enhances mi

298 such stimulation enhances APP synthesis and synapse formation with an ApoE4>ApoE3>ApoE2 potency rank

299 DIP mis-expression is sufficient to promote synapse formation with Dpr-expressing neurons and that d

300 ion of common genetic factors that drive the synapse formation within these subgraphs.