ライフサイエンスコーパス: synaptic activity

1 ner, targeting spines during periods of high synaptic activity.

2 uses loss of dendritic spines and changes to synaptic activity.

3 chronic disturbances in SPN excitability and synaptic activity.

4 hed pool of G-actin that can be regulated by synaptic activity.

5 reby limiting inactivation during repetitive synaptic activity.

6 SK channels are not efficiently activated by synaptic activity.

7 avioral preference is encoded by altered AWC synaptic activity.

8 ate neural plasticity and glutamate-mediated synaptic activity.

9 , nourish and maintain neuronal fidelity and synaptic activity.

10 Group I mGluRs as well as their influence on synaptic activity.

11 inergic and neuropeptide signalling modulate synaptic activity.

12 MKII) subunits form a complex that modulates synaptic activity.

13 hich depends on the history of probabilistic synaptic activity.

14 nto these neurons maintains normal levels of synaptic activity.

15 nse to prolonged perturbation of network and synaptic activity.

16 ion of intrinsic conductances with preceding synaptic activity.

17 n gating RA signaling pathway in response to synaptic activity.

18 curs through different pathways regulated by synaptic activity.

19 ion can be regulated locally in dendrites by synaptic activity.

20 unction in mouse rod photoreceptors and thus synaptic activity.

21 ASD-like behaviors and increased excitatory synaptic activity.

22 vation of CB2 receptors has little effect on synaptic activity.

23 fewer synaptic vesicles and lack spontaneous synaptic activity.

24 ein homeostasis at the synapse by regulating synaptic activity.

25 gressive loss of action potential output and synaptic activity.

26 , and surprisingly, CPX mobility depended on synaptic activity.

27 ter spike fidelity even during high rates of synaptic activity.

28 sory-evoked responses and reduced background synaptic activity.

29 at ultimately affects its fine-tuning during synaptic activity.

30 kinase whose functions include regulation of synaptic activity.

31 tic capacity, to adapt to conditions of high synaptic activity.

32 pid bouton formation in response to elevated synaptic activity.

33 urrent sources mediated by network GABAergic synaptic activity.

34 king, which depends on factors active during synaptic activity.

35 ncreased excitatory and decreased inhibitory synaptic activity.

36 in vivo leads to increased spine density and synaptic activity.

37 dynamin 1/3 and that operates during intense synaptic activity.

38 HT1A autoreceptor response, and lack of GABA synaptic activity.

39 temporal patterns of electrical and chemical synaptic activity.

40 non-FS, interneurons and exhibit synchronous synaptic activity.

41 a calcium barrier and sink during low-level synaptic activity.

42 neurons, and, in turn, this modulates NMDAR synaptic activity.

43 egulates alpha-synuclein dissociation during synaptic activity.

44 Ca(2+) signals associated with paired PF-CF synaptic activity.

45 ronize and modulate intra- and extracortical synaptic activity.

46 plasticity in the CNS is modulated by prior synaptic activity.

47 to lower ATP levels and impacts spontaneous synaptic activity.

48 d in >90% decrease in spontaneous excitatory synaptic activity.

49 of the postsynaptic membrane is sculpted by synaptic activity.

50 asodilator nitric oxide during glutamatergic synaptic activity.

51 ds/organoids displayed action potentials and synaptic activities.

52 voked-fMRI cortical responses (189%), evoked synaptic activity (46%), evoked neuronal firing (200%) a

53 Ts21 neurons displayed reduced synaptic activity, affecting excitatory and inhibitory s

54 is strongly upregulated by pathophysiologic synaptic activity after kainic acid (KA) exposure and it

55 ewer action potentials in response to evoked synaptic activity after occlusion, likely because of inc

56 gene induction during periods of heightened synaptic activity, allowing for appropriate responses of

57 Acid-sensing ion channels (ASICs) regulate synaptic activities and play important roles in neurodeg

58 min-1 cKO, and this change depends on strong synaptic activity and actin polymerization.

59 Synaptic activity and action potentials can independentl

60 plish these, we analyzed laminar profiles of synaptic activity and action potentials recorded in A1 o

61 ouse ZI GABAergic neurons at birth decreased synaptic activity and apical dendritic complexity of cor

62 At the molecular level, we find that synaptic activity and BDNF up-regulate Satb2, which itse

63 derived neurotrophic factor (BDNF) regulates synaptic activity and behavioral flexibility, and reduct

64 in cortical motor areas reflect asynchronous synaptic activity and contribute to plasticity processes

65 ) regulation in neurons during physiological synaptic activity and disease.

66 Hibernation causes reduced synaptic activity and experiments with mammals reveal th

67 Thus, in addition to attenuating cell death, synaptic activity and expression of ATF3 render hippocam

68 induced in neurons in response to excitatory synaptic activity and in glial cells in response to infl

69 sensitivity directly onto multiple inputs on synaptic activity and might begin to provide a molecular

70 In turn, and to fine-tune synaptic activity and neuronal communication, numerous n

71 ed posterior parietal and occipital cortical synaptic activity and nigrostriatal function than PD non

72 activity was caused in part by increases of synaptic activity and NMDA-receptor-dependent calcium sp

73 teract dynamically with neurons by modifying synaptic activity and plasticity.

74 dent mechanisms results in the modulation of synaptic activity and plasticity.SIGNIFICANCE STATEMENT

75 whether glial cells are capable of decoding synaptic activity and properties during early postdevelo

76 ytic cleavage of neuroligin-3 in response to synaptic activity and protein kinase C signaling resulti

77 ondrial biogenesis, mitochondrial fusion and synaptic activity and reduced mitochondrial fission in l

78 ntial and action potential firing, decreased synaptic activity and reduced synaptic plasticity.

79 agmentation, enhances fusion, biogenesis and synaptic activity and reduces Abeta42 levels and protect

80 1 levels normalizes the increased excitatory synaptic activity and reverses mechanical hypersensitivi

81 l impact on the apparent correlation between synaptic activity and running speed, demonstrating the i

82 Interestingly, synaptic activity and spatial memory induces Crtc1 depho

83 ation, resulting in persistent alteration of synaptic activity and stabilization of memory.

84 hat Mint overexpression increased excitatory synaptic activity and that APP was internalized predomin

85 govern translational control in response to synaptic activity and the mRNA populations that are spec

86 RRK2 mutation dramatically alters excitatory synaptic activity and the shape of postsynaptic structur

87 te the position of lysosomes is regulated by synaptic activity and thus plays an instructive role in

88 t the interaction between glutamate-mediated synaptic activity and TrkB signaling is imperative to BD

89 ded on spontaneous but not evoked excitatory synaptic activity and was shown to be N-methyl-d-asparta

90 e interval evoking synchronous pre- and post-synaptic activity and which strengthens interregional co

91 nd glial inflammatory responses, spontaneous synaptic activity, and active cerebral metabolism in the

92 naptic drive, elevated levels of spontaneous synaptic activity, and decreased neuronal intrinsic exci

93 s converged on pathways of neurodevelopment, synaptic activity, and immune functions.

94 tructural and functional brain connectivity, synaptic activity, and information processing require hi

95 ngent upon neuronal activity, NMDAR-mediated synaptic activity, and L-type Ca(2+) channel activity.

96 hannel that regulates neuronal excitability, synaptic activity, and retinal homeostasis.

97 fasting-induced spinogenesis and excitatory synaptic activity, and that the AMPK phosphorylation tar

98 s the buildup of acquired neuroprotection, a synaptic activity- and gene transcription-mediated incre

99 0 pathway in the neuronal response to strong synaptic activity as a consequence of excitotoxic insult

100 ariances, and decrease the autocovariance of synaptic activity as a consequence of single node and la

101 gonist functions are driven by the levels of synaptic activity as inferred by recording long-term pot

102 ndent CORT-induced suppression of inhibitory synaptic activity, as previously observed in males.

103 sent the brain's response to the increase in synaptic activity associated with prolonged wake, cleari

104 Using slice recordings and modeling of synaptic activity at cerebellar granule cell to Purkinje

105 Furthermore, synaptic activity at cornu ammonis 3-cornu ammonis 1 syn

106 g two-electrode dynamic clamp and found that synaptic activity at physiologically relevant rates elic

107 CaMKII in triggering long-lasting changes in synaptic activity at some synapses has been established,

108 ustering behavior through the measurement of synaptic activity at the single-cell level, thus providi

109 ferent inputs by diffuse stimulation changes synaptic activity at the target brain region.

110 psyn-EGFP (WT and mutants) is independent of synaptic activity because they were inserted at denervat

111 to what extent alphaSyn aggregates modulate synaptic activity before neuron loss, we demonstrate tha

112 ascr#3 imprinting is mediated by increased synaptic activity between the ascr#3-sensing ADL neurons

113 We found that synaptic activity bi-directionally regulates neuronal Te

114 Specifically, we show that synaptic activity blockade persistently down-regulates m

115 We studied mitochondrial and synaptic activities by measuring mRNA and the protein le

116 py methods, we studied (i) mitochondrial and synaptic activities by measuring mRNA and the protein le

117 novo spinogenesis, but instead may increase synaptic activity by inducing morphological and function

118 in the control of the efficacy of GABAergic synaptic activity by regulating the trafficking and synt

119 ated release of presynaptic glutamate during synaptic activity by regulating tissue levels of the tra

120 eated dTg-211 cortices overrepresentation of synaptic activity, Ca(2+) transmembrane transport, TGFBR

121 This work demonstrates that synaptic activity can induce mRNA localization and local

122 Finally, increased synaptic activity caused an increase in the ratio of l-l

123 mouse and rat primary hippocampal cultures, synaptic activity caused an up-regulation of glycolytic

124 lating gene expression in response to global synaptic activity changes.

125 ntly, inner retinal neurons develop aberrant synaptic activity, compounding visual impairment.

126 namically form and dissociate in response to synaptic activity, comprising the biophysical basis for

127 Because increased MRI signal reflects synaptic activity, concomitantly increased signals in th

128 Healthy control levels of synaptic activity could be restored by treatment of ChAc

129 Our data indicate that synaptic activity counteracts the negative effects of Ta

130 ecreased slow wave activity (SWA), increased synaptic activity, decreased glymphatic clearance, and i

131 Prolonged blockade of synaptic activity decreases resting Ca(2+) levels in neu

132 rong correlations between action potentials, synaptic activity, dendritic complexity and gene express

133 is a new modulator, operating at the NE, of synaptic activity-dependent neuronal functions.

134 e we show that in mouse hippocampal neurons, synaptic activity-dependent nucleo-cytoplasmic shuttling

135 Neuronal activity also evokes non-synaptic activity-dependent potassium currents that are

136 Stimulating sympathetic neurons with virtual synaptic activity, designed to replicate in vivo recordi

137 The local synaptic activity differs between hemispheres in prepube

138 ase (AMPK) is also an important regulator of synaptic activity-driven eEF2K dynamics in neurons.

139 Synaptic activity drives changes in gene expression to p

140 Together, these results suggest that intense synaptic activity drives tau to the postsynaptic density

141 gs reveal a signaling pathway that regulates synaptic activity during central nervous system developm

142 The role of synaptic activity during early formation of neural circu

143 he occurrence of specific impairments in the synaptic activity during SIV infection.SIGNIFICANCE STAT

144 d stronger excitatory synapses and expressed synaptic activity earlier in development.

145 at in the presence of spontaneous background synaptic activity, electrically coupled cerebellar Golgi

146 iving downstream molecular events related to synaptic activity embedded in these systems.

147 esult, an imbalance of excitatory-inhibitory synaptic activity emerges in the PFC that correlates lin

148 onal spikes in concert with local population synaptic activity, enhancing comprehension of neural pro

149 conductance had major negative consequences: synaptic activity evoked action potentials with lower fi

150 DCS applied during synaptic activity facilitates cumulative neuromodulation

151 ng increases dendritic spines and excitatory synaptic activity; feeding does the opposite.

152 SD) is a transient propagating excitation of synaptic activity followed by depression, which is impli

153 rative disorders, suggesting that uncoupling synaptic activity from nuclear signaling may prompt syna

154 Hence, because of their ability to decode synaptic activity, glial cells should be able to integra

155 Last, synaptic activity has a small impact on intrinsic membra

156 e of glutamate triggered by pathophysiologic synaptic activity has been put forward as key mechanism

157 Stimulation of synaptic activity has been shown to be protective in mod

158 hypothesis is that increased random afferent synaptic activity (i.e. synaptic noise) within the epile

159 at alphaSyn preformed fibrils (PFFs) reduced synaptic activity in a dose- and time-dependent manner.

160 otoxic dendritic damage following a burst of synaptic activity in a manner dependent on platelet-acti

161 with recombinant human alphaSyn compromised synaptic activity in a time- and dose-dependent manner a

162 in brain slices rapidly increased excitatory synaptic activity in anorexigenic proopiomelanocortin ne

163 amics, enhances mitochondrial biogenesis and synaptic activity in APP mice.

164 cs and enhances mitochondrial biogenesis and synaptic activity in APP mice; and that SS31 may confer

165 e-projecting vCA1 neurons induces excitatory synaptic activity in both the mPFC and amygdala.

166 f neural compensation consisting of enhanced synaptic activity in brain regions spared by Abeta load.

167 Thus, CALHM1 controls synaptic activity in cerebral neurons and is required fo

168 analysis revealed a pathologically elevated synaptic activity in ChAc MSNs.

169 ology, we detected a pathologically enhanced synaptic activity in ChAc neurons.

170 on NL-1 and is phosphorylated in response to synaptic activity in cultured rodent neurons and sensory

171 ent manner, leading to reduced GlyR-mediated synaptic activity in cultured spinal cord neurons and th

172 Excitatory synaptic activity in D2017A SPNs was similar to wild typ

173 ade implicated in behavioral plasticity, and synaptic activity in different subpopulations of striata

174 othesis that global reductions of background synaptic activity in DOCs will associate with changes in

175 f GABA, ACh, and glutamate receptor-mediated synaptic activity in DSGCs evoked by motion.

176 and calcium currents, voltage responses and synaptic activity in hair cells from the lateral line an

177 ium transients in the cell nucleus evoked by synaptic activity in hippocampal neurons function as a s

178 population activity, but its relationship to synaptic activity in individual neurons is not fully est

179 This work highlights the importance of synaptic activity in initiating signalling cascades that

180 es to external stimuli, we imaged neural and synaptic activity in larval zebrafish during fictive swi

181 plore eEF2K dynamics in depth, we stimulated synaptic activity in mouse primary cortical neurons.

182 for increased frequency of spontaneous GABA synaptic activity in MSNs.

183 lace preference (CPP), focusing on GABAergic synaptic activity in neurons of the central nucleus of t

184 NF/TrkB signaling as a critical regulator of synaptic activity in ovBNST, which acts at postsynaptic

185 How the TSCs sense the synaptic activity in physiological conditions remains un

186 hen apply them to correcting measurements of synaptic activity in populations of vasoactive-intestina

187 Long-term potentiation and depression of synaptic activity in response to stimuli is a key factor

188 amics, enhances mitochondrial biogenesis and synaptic activity in Tau mice.

189 investigated how PPARgamma agonism affected synaptic activity in Tg2576 DG.

190 Drosophila larvae with (and without) blocked synaptic activity in the brain, suboesophageal ganglion

191 eric ligand-gated ion channels that regulate synaptic activity in the central and peripheral nervous

192 ic acetylcholine receptors (nAChRs) modulate synaptic activity in the central nervous system.

193 The afferent synaptic activity in the hippocampus was modulated by fo

194 ficits induced by GI and produces changes in synaptic activity in the hippocampus.

195 ized in this brain region, leading to higher synaptic activity in the right than in the left hemisphe

196 Thus, under conditions of increased synaptic activity in the RVLM, glycinergic inhibition is

197 The model allows computing the statistics of synaptic activity in the spontaneous condition and in pu

198 GluN2D NMDA receptor subunits contribute to synaptic activity in the STN and may represent potential

199 Notably, synaptic activity in these neurons can be restored by co

200 uN2D-containing NMDA receptors contribute to synaptic activity in these regions.

201 Next, we engineered mice in which synaptic activity in this gut-to-brain circuit was genet

202 Subsequent silencing of VGluT1(+) synaptic activity in VGluT1 KO mice significantly reduce

203 ble membrane tubules in vitro and to promote synaptic activity in vivo.

204 n of excitation and inhibition of excitatory synaptic activity induced by exogenous application of ca

205 reas steady-state Abeta levels were similar, synaptic activity-induced endogenous Abeta production wa

206 nd promotes the transcription of a subset of synaptic activity-induced genes, including brain-derived

207 Here we show that following synaptic activity-induced SCOP degradation, SCOP is rapi

208 Synaptic activity induces rapid Ca(2+) signals mediated

209 ce salience, through alterations in afferent synaptic activity, induces rapid changes in endocannabin

210 t synapses to which it has bound and whether synaptic activity influences Abeta synaptic binding and

211 rritory is the source of travelling waves of synaptic activity into adjacent cortical areas.

212 eptors (mGluRs) are also suitable to convert synaptic activity into intracellular signals for synapti

213 resence of voltage fluctuations arising from synaptic activity is a critical component in models of g

214 architecture and modulate it in response to synaptic activity is a crucial component of the cellular

215 Loss of synapses or alteration of synaptic activity is associated with cognitive impairmen

216 Here we show that synaptic activity is coupled, via the NMDA receptor (NMD

217 ed in Munc18-1(-/-) mice, demonstrating that synaptic activity is dispensable for early nervous syste

218 "fatigue" accrued during wake, when overall synaptic activity is higher than in sleep.

219 but the impact of RAB39B loss of function on synaptic activity is largely unexplained.

220 A presynaptic role for CaMKII in regulating synaptic activity is less clear with evidence for CaMKII

221 Aberrant synaptic activity is observed in many neurological disor

222 napsin, perturbed reclustering of SVs during synaptic activity is observed.

223 ing of axon terminals by positional cues and synaptic activity is required for appropriate numbers of

224 to corticostriatal synapses, thalamostriatal synaptic activity is unaffected by Sapap3 deletion.

225 The reduced synaptic activity is unlikely due to changes in motoneur

226 trans-synaptic spread of tau pathology with synaptic activity itself.

227 One proposed model suggests that synaptic activity leads to increased Abeta deposition.

228 egments in the dark, modulates photoreceptor synaptic activity; light exposure stimulates a reduction

229 that changes in action potential firing and synaptic activity may be secondary to altered resting me

230 on these data we suggest the existence of a synaptic activity-mediated neuronal Warburg effect that

231 Core-glycosylation is regulated by synaptic activity, modulates synaptic signaling and acce

232 induced action potential activity, enhanced synaptic activity, more complete development of a mature

233 In response to pathophysiologic synaptic activity, multiple signaling cascades are activ

234 i are enriched in auditory processes such as synaptic activities, nervous system processes, inner ear

235 alter the frequency or temporal precision of synaptic activity observed.

236 rence electrode, they often reflect those of synaptic activity occurring in distant sites as well.

237 Synaptic activity of axons and interaxonal competition a

238 d that DAF failed to perturb singing-related synaptic activity of HVCX cells, although many of these

239 ty and optimally supports the electrical and synaptic activity of neurons in culture.

240 cytes selectively promote neurite growth and synaptic activity of neurons only from the same region i

241 napse elimination is accelerated by enhanced synaptic activity of one axon and also by increased area

242 recorded electrophysiological changes in the synaptic activity of the two types of medium spiny neuro

243 The synaptic activity of V1 neurons is given as input to the

244 to enhance excitatory synapses dependent on synaptic activity or Ca(2+)/calmodulin kinase II (CaMKII

245 ion of entropy, meaning that the spontaneous synaptic activity outlines a larger multidimensional act

246 ayed reward, which poses the question of how synaptic activity patterns associate with a delayed rewa

247 and as key regulators of synapse formation, synaptic activity, plasticity, and synaptic vesicle recy

248 se findings suggest that central glycinergic synaptic activity plays a vital role in regulating MN mo

249 Here, we show that increased synaptic activity prior to excitotoxic injury protects,

250 rn of gene expression changes suggested that synaptic activity promotes a shift of neuronal energy me

251 sition confers specificity to the program of synaptic activity-regulated gene transcription in develo

252 mate receptors (NMDARs) are key mediators of synaptic activity-regulated gene transcription in neuron

253 re re-examined previously identified sets of synaptic activity-regulated genes to identify genes that

254 data suggest that spontaneous glutamatergic synaptic activity regulates constitutive neuronal COX-2

255 , when, and how much zinc is released during synaptic activity remains highly controversial.

256 Synaptic activity reshapes the morphology of dendritic s

257 These three proteins bind to the synaptic activity response element (SARE), an enhancer s

258 This triggered condensed chromatin at the synaptic activity response element site and promoter of

259 ing in the amygdala, particularly at the Arc synaptic activity response element site, contributes to

260 Chronic inhibition of synaptic activity resulted in opposite outcomes, with bu

261 We find that synaptic activity results in a rapid, but transient, inc

262 ndritic spine loss, patch-clamp recording of synaptic activity revealed an increase in miniature EPSC

263 ALS (120 d), but PSC detection of endogenous synaptic activity revealed by intracellular Ca(2+) chang

264 hich morphogens, transcription programs, and synaptic activity sculpt neuronal form.

265 Thus, Tet3 serves as a synaptic activity sensor to epigenetically regulate fund

266 ction by modulating dendritic morphology and synaptic activity.SIGNIFICANCE STATEMENT Sulfotransferas

267 A accumulates at activated synapses and that synaptic activity simultaneously triggers mRNA decay tha

268 ng Ca(2+)-permeable forms and thereby alters synaptic activity, specifically in hippocampal neurons.

269 ynapses capable of capturing both neural and synaptic activity statistics relevant to BBCI conditioni

270 rom dendrites or cytosol to the nucleus upon synaptic activity, suggesting that they could contribute

271 nds to short pulses of correlated background synaptic activity synchronizing the output of cortical n

272 ERK1/2 activation, and long term changes in synaptic activity that are implicated in learning, memor

273 eveal that detection inside the RF increases synaptic activity that depolarizes membrane potential re

274 h steady-state LFPs could reflect underlying synaptic activity that does not necessarily lead to cort

275 The synaptic activity that is evoked by visual stimulation d

276 thology likely arises from poorly controlled synaptic activity that leads to excitotoxicity and neuro

277 Although UP states are maintained by synaptic activity, the mechanisms that underlie the init

278 ese oscillations arise from local inhibitory synaptic activity, these findings point to excitation-in

279 en species (ROS) in neurons and they control synaptic activity through their roles in energy producti

280 ediate early gene product Arc/Arg3.1 couples synaptic activity to postsynaptic endocytosis of AMPA-ty

281 leased opioids as neuromodulators engaged by synaptic activity to regulate moment-to-moment neuronal

282 edium to high expression, possibly by tuning synaptic activity to the stimulus features and hence a m

283 orded local field potentials as a measure of synaptic activity together with spiking activity and low

284 excitatory-inhibitory balance of prefrontal synaptic activity toward a state of disinhibition.

285 This raises an important question: how does synaptic activity trigger translation of once-silenced m

286 of astrocytic genes are acutely regulated by synaptic activity via mechanisms involving cAMP/PKA-depe

287 consequence of dopamine release, D2-receptor synaptic activity was assessed via virally overexpressed

288 Across tested frequencies, sustained synaptic activity was modulated by DCS with polarity-spe

289 ubset of sustained ON bipolar cells in which synaptic activity was suppressed by fluctuations at freq

290 left is highly dynamic and depends on recent synaptic activity, we explored the kinetics of ASIC1a an

291 To test whether alphaSyn aggregates modulate synaptic activity, we used a recently developed model in

292 ndent changes in membrane resistance amplify synaptic activity, whereas the frequency of voltage fluc

293 ation, we discovered new maps for excitatory synaptic activity, which were organized similarly to tho

294 o implement and allows population imaging of synaptic activity while scanning a single plane in a sta

295 activity and has the potential to coordinate synaptic activity with a BMP retrograde signal required

296 n synaptic plasticity and the integration of synaptic activity with neuronal activity.

297 assess neuronal excitability and the derived synaptic activity within a controlled microenvironment w

298 of inhibition under conditions of increased synaptic activity within the RVLM.

299 ergy demands of growth, differentiation, and synaptic activity within their complex cellular architec

300 tected synapses, while chronic inhibition of synaptic activity worsened Tau pathology and caused detr