ライフサイエンスコーパス: synaptic connection

1 ions to the prediction of the longevity of a synaptic connection.

2 two forms of plasticity interact at the same synaptic connection.

3 homeostasis through continued refinement of synaptic connections.

4 ion can be shaped by varying the strength of synaptic connections.

5 about activity-dependent plasticity of their synaptic connections.

6 in ways that are not easily predicted by its synaptic connections.

7 plays an important role in the formation of synaptic connections.

8 ced loss of Inner Hair Cell - Auditory Nerve synaptic connections.

9 ith loss of Inner Hair Cell - Auditory Nerve synaptic connections.

10 sed of local, subcortical, and intercortical synaptic connections.

11 f orthogonal laminar and vertical excitatory synaptic connections.

12 onal membrane properties and formed abundant synaptic connections.

13 l activity that promote the establishment of synaptic connections.

14 sms to downregulate DLK as they form stable, synaptic connections.

15 neurons and PV interneurons formed frequent synaptic connections.

16 in the control circuits and mapping of their synaptic connections.

17 s are thought to reflect those of excitatory synaptic connections.

18 nes that allow predicting future turnover of synaptic connections.

19 te balance between excitatory and inhibitory synaptic connections.

20 rgic synaptic vesicles and involved in local synaptic connections.

21 projections into striatal organoids and form synaptic connections.

22 spinal neurons and testing of 3489 potential synaptic connections.

23 cycles and by comprehensively mapping their synaptic connections.

24 etwork because of pervasive and facilitating synaptic connections.

25 logous neurons with different layer-specific synaptic connections.

26 ce to assess the morphology and lifetimes of synaptic connections.

27 a period of refinement to eliminate aberrant synaptic connections.

28 ely control the development and longevity of synaptic connections.

29 ured to reveal the patterns and strengths of synaptic connections.

30 that they involve strengthening or weakening synaptic connections.

31 GABAergic neurons, which communicate through synaptic connections.

32 eved to be stored in the brain as changes in synaptic connections.

33 t each other to form a network of inhibitory synaptic connections.

34 nt on the activity that emerges from nascent synaptic connections.

35 one sex, leading to sex-specific patterns of synaptic connections.

36 ty-dependent signals to establish functional synaptic connections.

37 when starting from naive or already trained synaptic connections.

38 tworks through a redistribution of recurrent synaptic connections.

39 heir normal territory and establish aberrant synaptic connections.

40 ritical during development and plasticity of synaptic connections.

41 ophrenia, possibly due to loss of excitatory synaptic connections.

42 on not restricted to morphologically defined synaptic connections.

43 ere they elaborate specific morphologies and synaptic connections.

44 t depend on the precise arrangement of local synaptic connections.

45 ress that cause neuronal atrophy and loss of synaptic connections.

46 onal roles for the functional development of synaptic connections.

47 zatin does not compromise the maintenance of synaptic connections.

48 correlation on fast timescale due to shared synaptic connections.

49 promote and inhibit the removal of specific synaptic connections.

50 l circuits requires selective elimination of synaptic connections.

51 neurons via direct glutaminergic excitatory synaptic connections.

52 ween spiking neurons via a complex system of synaptic connections.

53 nd maturation of their afferent and efferent synaptic connections.

54 circuit is determined by the details of its synaptic connections.

55 Nervous system function relies on precise synaptic connections.

56 Mapping such networks at the level of synaptic connections, a field called connectomics, began

57 ize wiring length for a functional number of synaptic connections, a phenomenon called wiring optimiz

58 is refined via selection and elimination of synaptic connections, a process that is prolonged in hum

59 Neurons can maintain stable synaptic connections across adult life.

60 VIP+ cell morphologies, receptive fields and synaptic connections advances our understanding of their

61 We found that unitary synaptic connections among claustrocortical (ClaC) neuro

62 NCE STATEMENT Dendrites are the sites of the synaptic connections among neurons.

63 ccompanied by a reduction in the strength of synaptic connections and altered functional connectivity

64 of the strength of excitatory and inhibitory synaptic connections and are associated with modulation

65 e that enabled us to selectively examine the synaptic connections and behavioural role of the CA2 reg

66 induced neuroplastic effects at the level of synaptic connections and circuits.

67 An offset in the weighting of synaptic connections and differential use of fast and sl

68 ists into adulthood, leading to strengthened synaptic connections and enhanced olfactory memory acqui

69 ived neurons disrupts the formation of these synaptic connections and hinders functional recovery aft

70 Thus, neuronal activity restores synaptic connections and improves significantly the seve

71 postsynaptic actions in dlPFC, strengthening synaptic connections and improving cognitive function.

72 Our findings indicate that RIN1 destabilizes synaptic connections and is a key player in postsynaptic

73 , a process requiring functional analysis of synaptic connections and morphological identification of

74 erophilically, and they are thought to shape synaptic connections and neural circuits by acting in tr

75 Mapping synaptic connections and projections is crucial for unde

76 gical mechanisms include unmasking of latent synaptic connections and rapid synaptic remodeling drive

77 ng and extinction induce opposing changes in synaptic connections and somatic activities of layer 5 p

78 en inflammation does occur, microglia modify synaptic connections and synaptic plasticity required fo

79 d analytical method was used to quantify the synaptic connections and to assess the kinetics of synap

80 dendrites is used to guide the formation of synaptic connections and to store information.

81 nge networks, local circuits, and individual synaptic connections) and highlights opportunities for f

82 erm changes in cell specification, growth of synaptic connections, and adaptation that occur througho

83 ugh the network size, strength and number of synaptic connections, and connection architecture may va

84 ntributes to behavioral deficits by altering synaptic connections, and RhoA-ROCK inhibition enhances

85 ulation activities, the fixed parameters are synaptic connections, and the latent variables are multi

86 ction and development in juvenile flies when synaptic connections are actively being formed in respon

87 The formation and refinement of synaptic connections are dependent on the activity that

88 These synaptic connections are detected by trans-synaptic Neur

89 Neuronal synaptic connections are either chemical or electrical,

90 In the developing nervous system, synaptic connections are formed in excess and must remod

91 ctivity-dependent changes in the strength of synaptic connections are fundamental to the formation an

92 ment, as this is when central and peripheral synaptic connections are made onto and from MNs.

93 Surprisingly, reciprocal inhibitory synaptic connections are major players in choosing, sequ

94 rms of synaptic plasticity specific to these synaptic connections are markedly impaired at an early s

95 Redundant synaptic connections are removed in a process known as s

96 The laminar synaptic connections are symmetric sparse, random, and d

97 s (JL) matrices implemented by sparse random synaptic connections are thought to be a prime candidate

98 ablishment, specification, and validation of synaptic connections are thought to be mediated by inter

99 ems that different circuits, indeed specific synaptic connections, are differentially sensitive to th

100 a constant increase in the number of links (synaptic connections) as a function of the number of nod

101 ExM further resolved putative synaptic connections, as well as molecular differences b

102 Using a modified GRASP method to probe synaptic connections at the single-cell level, we reveal

103 x2-1-derived interneurons possess functional synaptic connections before emerging pyramidal cell netw

104 neurons interacting with each other through synaptic connection between axons and dendrites, therefo

105 tch experiments which allowed probing of 150 synaptic connections between 17 neurons in one human cor

106 ned anatomically at a cellular scale as 2287 synaptic connections between 279 neurons.

107 s to investigate the functional operation of synaptic connections between a specific population of ex

108 Here we interrogate synaptic connections between afferent pathways, PV-INs,

109 Such noise exposure destroys synaptic connections between cochlear hair cells and aud

110 e or aging, there can be massive loss of the synaptic connections between cochlear sensory cells and

111 ally depends on the selection of appropriate synaptic connections between cortical projection and spi

112 Dendrogram analyses of all the synaptic connections between DAN-i1 and its two main tar

113 The generation of precise synaptic connections between developing neurons is criti

114 mbined with Ca(2+) imaging, we characterized synaptic connections between dFB neurons and distinct se

115 lly, anatomical studies revealed specialized synaptic connections between epithelial cells and nerve

116 The strength and variability of electrical synaptic connections between GABAergic interneurons are

117 In the present study, we analyzed unitary synaptic connections between GCs and basket cells in acu

118 g techniques, we examined the effects of the synaptic connections between glycinergic interplexiform

119 icantly decreased, indicating a reduction in synaptic connections between hippocampal newborn neurons

120 cified during development, (2) revealing the synaptic connections between identified cell types ("con

121 Here, we investigated patterns of synaptic connections between identified motoneurons with

122 Recurrent synaptic connections between neighboring neurons are a k

123 ng training.SIGNIFICANCE STATEMENT Recurrent synaptic connections between neighboring neurons are cha

124 ic insights into the development of specific synaptic connections between nerve cells and contribute

125 Precise patterns of synaptic connections between neurons are encoded in thei

126 Lineage regulates the synaptic connections between neurons in some regions of

127 reveals the existence of sexually dimorphic synaptic connections between neurons present in both sex

128 Stereotypic patterns of synaptic connections between neurons underlie the abilit

129 and stability is constrained by the sign of synaptic connections between neurons within the network.

130 machinery immunostaining can define putative synaptic connections between neurons, as well as map put

131 in damage involve changes in the strength of synaptic connections between neurons.

132 and development of excitatory and inhibitory synaptic connections between neurons.

133 In rodent visual cortex, synaptic connections between orientation-selective neuro

134 triple EM labeling experiments demonstrated synaptic connections between primary afferents, descendi

135 acilitate future physiological assessment of synaptic connections between pRS neurons and spinal neur

136 effects of Tat on inhibitory and excitatory synaptic connections between rat hippocampal neurons usi

137 l adhesion proteins required for appropriate synaptic connections between specific subtypes of retina

138 orporates trace learning in the feed-forward synaptic connections between successive neuronal layers.

139 Here we probe alterations in the synaptic connections between the dentate gyrus and CA3,

140 and withdrawal networks, we found no direct synaptic connections between the interneuronal and moton

141 nervous system, it is necessary to know the synaptic connections between the neurons, yet to date, o

142 However, it remains unclear when synaptic connections between these structures emerge or

143 We found rapid, strong excitatory synaptic connections between uPNs and LNs.

144 s, such as the biophysical parameters of, or synaptic connections between, particular recorded cells.

145 ansactivator of transcription (Tat) disrupts synaptic connections both in vitro and in vivo and has b

146 ited ability to extend neurites and make new synaptic connections, but the mechanisms that inhibit su

147 ronal cell types and precise arrangements of synaptic connections, but the processes that generate th

148 role for astrocytes as organizers of active synaptic connections by coordinating both pre and post s

149 Strengthening of synaptic connections by NMDA (N-methyl-d-aspartate) rece

150 We showed that direct synaptic connection can exist between AgRP1 and AgRP2 ne

151 sponses must exist before specific recurrent synaptic connections can be established.

152 Advances in automated mapping of the brain's synaptic connections (connectomics) suggest that the com

153 presynaptic expression of En strengthens the synaptic connection, consistent with there being more sy

154 Stereotyped synaptic connections define the neural circuits of the b

155 c development, thalamic axons must establish synaptic connections despite the presence of the more ab

156 Divergent synaptic connections did not contribute directly to the

157 d synaptic plasticity to allow the change of synaptic connections due to the training in awake or rep

158 onment and play essential roles in sculpting synaptic connections during brain development.

159 The formation and disruption of synaptic connections during development are a fundamenta

160 lly, we identified sidekick-1--important for synaptic connections during development--as a critical P

161 ines is a key component of the refinement of synaptic connections during learning.

162 -sensitive primary afferent nerve fibers via synaptic connections, enabling them to detect and transd

163 Precise coordination of synaptic connections ensures proper information flow wit

164 elimb area of mouse M1 have multiple L4-like synaptic connections: excitatory input from thalamus, la

165 tes that changes in neuronal activity of one synaptic connection following early-life pheromone expos

166 ecific, and sensitive to modulation, and the synaptic connections formed by these newborn cells are f

167 neurons suppressed development of excitatory synaptic connections from all local input pathways teste

168 Thalamocortical neurons have thousands of synaptic connections from layer VI corticothalamic neuro

169 we mapped over 300 excitatory and inhibitory synaptic connections from more than 1,700 neurons that w

170 jection is partially explained by changes in synaptic connections from primary mechanoafferents to fi

171 The strength of synaptic connections fundamentally determines how neuron

172 et of hub-like neurons have large numbers of synaptic connections (>40).

173 s and 50 projection neuron (PN) classes form synaptic connections in 50 glomerular compartments in th

174 Establishment of functional synaptic connections in a selective manner is essential

175 ity, and abnormally reduced local excitatory synaptic connections in CA1 neurons.

176 ophila visual system, different neurons form synaptic connections in different layers.

177 ifferent neuronal populations, Npas4 affects synaptic connections in excitatory and inhibitory neuron

178 Inhibitory autapses are self-innervating synaptic connections in GABAergic interneurons in the br

179 d optogenetic approaches to re-examine these synaptic connections in mice.

180 elayed maturation and network integration of synaptic connections in middle layers.

181 elayed maturation and network integration of synaptic connections in middle layers.SIGNIFICANCE STATE

182 sed connectomics aims to comprehensively map synaptic connections in neural tissue.

183 rs regulate neuronal response properties and synaptic connections in order to adjust circuit function

184 During the process of skill learning, synaptic connections in our brains are modified to form

185 strate selective reorganization of recurrent synaptic connections in the adult neocortex following no

186 optic nerve, and (2) the re-establishment of synaptic connections in the brain.

187 e spatial distribution and strength of local synaptic connections in the central nucleus of the infer

188 beta) triggers the elimination of excitatory synaptic connections in the CNS, an early manifestation

189 receptor, Frazzled, dictate the strength of synaptic connections in the giant fiber system (GFS) of

190 for efficient information transfer at DG-CA3 synaptic connections in the intact circuit.

191 muscular junctions and emerging parallels at synaptic connections in the mammalian central nervous sy

192 Synaptic connections in the nervous system are rearrange

193 ed by dramatic increase of newly established synaptic connections in the nervous system.

194 Establishment of synaptic connections in the neuropils of the developing

195 In addition, the synaptic connections in the outer plexiform layer are de

196 Plasticity of synaptic connections in the primary motor cortex (M1) is

197 ct of inflammation and cytokine elevation on synaptic connections in the primary somatosensory cortex

198 e investigated functional AII amacrine-->RGC synaptic connections in the retina of the guinea pig (Ca

199 we investigated functional AII amacrine->RGC synaptic connections in the retina of the guinea pig (Ca

200 We dissected the excitatory synaptic connections in the somatosensory thalamus forme

201 onnectivity of all four types of hippocampal synaptic connections, including two forms of increased i

202 m algebraic topology, we find that weakening synaptic connections increase spatial learning times, pr

203 aracterized by a change in the strength of a synaptic connection induced by repetitive and properly p

204 Long-lasting changes in synaptic connections induced by relevant experiences are

205 tem requires a significant refinement of the synaptic connections initially formed during development

206 Unitary GPe-STN synaptic connections initially generated large conductan

207 The elaboration of nascent synaptic connections into highly ordered neural circuits

208 Optimal mPFC functioning relies on synaptic connections involving dendritic spines in pyram

209 Loss of synaptic connections is a hallmark of many neurocognitiv

210 This target area of synaptic connections is characterized by extensive ramif

211 Formation of appropriate synaptic connections is critical for proper functioning

212 Maintaining established synaptic connections is essential for generating functio

213 Delineation of functional synaptic connections is fundamental to understanding sen

214 EMENT The ability of neurons to modify their synaptic connections, known as synaptic plasticity, is a

215 ng to characterize the long-range excitatory synaptic connections made by multiple cortical and thala

216 hat there is some loss of specificity in the synaptic connections made in the SCG during reinnervatio

217 has been frustrated by the lack of detailed synaptic connection maps, or connectomes.

218 These augmented synaptic connections mediate a feedforward inhibition of

219 o investigate how structural variation among synaptic connections might affect neural computation, we

220 nd users should be cognizant that functional synaptic connections might exist despite the absence of

221 the biophysical properties of a well-defined synaptic connection of the cortical microcircuit of huma

222 We reconstructed the morphologies and synaptic connections of all 983 neurons within the three

223 o track changes in the afferent and efferent synaptic connections of developing neocortical interneur

224 ermis functions could be mediated by modular synaptic connections of distinct fastigial cell types wi

225 oscopy, we evaluated morphology, number, and synaptic connections of dopaminergic cells and their pos

226 arily coded by dopamine, which modulates the synaptic connections of medium spiny neurons in the stri

227 al part in the maintenance and refinement of synaptic connections, often via competitive mechanisms,

228 is elegans DA cholinergic motor neurons form synaptic connections only on their dorsal axons.

229 c circuit, with an enhancement of excitatory synaptic connections onto MSNs.

230 the songbird basal ganglia that makes strong synaptic connections onto output pallidal neurons, often

231 CNS and regulates the density of excitatory synaptic connections onto pyramidal neurons in a genetic

232 both SPNs and cholinergic interneurons, and synaptic connections onto SPNs are made exclusively over

233 We have characterized the afferent synaptic connections onto these neurons in the rat subst

234 lve early specification of extremely precise synaptic connections or, by contrast, emerge slowly in c

235 f a cortical hypercolumn linked via vertical synaptic connections, or two different cortical hypercol

236 Networks with few synaptic connections per neuron and network-activity-dep

237 The multifaceted synaptic connections provide spinal networks with a rema

238 LN-LN synaptic connections putatively implement a bistable gai

239 maller on average but are still able to make synaptic connections regardless of their size, as assess

240 implicated in the assembly and modulation of synaptic connections required to shape neural circuits,

241 well their local gap junction and inhibitory synaptic connections reveals this period to be highly dy

242 A comprehensive mapping of synaptic connections reveals three recurrent circuit mod

243 can cooperate to mediate release at a given synaptic connection.SIGNIFICANCE STATEMENT During synapt

244 al network size, the addition of neurons and synaptic connections starts to impede learning performan

245 neurons form highly stereotypic patterns of synaptic connections that are designed to serve specific

246 Immature neural circuits form excessive synaptic connections that are later refined through prun

247 are interconnected with recurrent excitatory synaptic connections that are thought to amplify signals

248 y neurons display characteristic patterns of synaptic connections that are under genetic control.

249 expression leads to a profound overgrowth of synaptic connections that correlates directly with the l

250 Wnt signalling increases axon plasticity and synaptic connections that drive greater functional recov

251 stnatal life are prerequisites for selective synaptic connections that mediate meaningful neurotransm

252 uencies did not deviate between autaptic and synaptic connections, the frequency of mEPSCs in mixed p

253 tudy tested the hypothesis that the types of synaptic connections these boutons form are altered with

254 promote long-term changes in the strength of synaptic connections through a phenomenon known as synap

255 hway split is thought to occur at individual synaptic connections through a sign-inverting synapse in

256 e expressed by strengthening or weakening of synaptic connections through morphological changes.

257 an rapidly and reversibly silence excitatory synaptic connections through the regulation of presynapt

258 We describe synaptic connections through which information essential

259 We describe the synaptic connections through which information required

260 MDA receptor activity is involved in shaping synaptic connections throughout development and adulthoo

261 ay a central role in shaping the strength of synaptic connections throughout development and in media

262 ngs in neonatal CA1, MGE interneurons formed synaptic connections to and from neighboring pyramidal c

263 ind that robustness to output noise requires synaptic connections to be in a balanced regime in which

264 Glutamate neurotransmission refines synaptic connections to establish the precise neural cir

265 unclear how local excitatory and inhibitory synaptic connections to excitatory neurons are spatially

266 ntive to evaluate interventions that restore synaptic connections to treat depression.

267 central nervous system ranging from removing synaptic connections, to maintaining brain homeostasis b

268 Synaptic connections undergo activity-dependent plastici

269 Synaptic connections underlie learning and memory in the

270 direct anatomical visualization of callosal synaptic connections using post hoc expansion microscopy

271 The strength of synaptic connections varies significantly and is a key d

272 replay', the active potentiation of relevant synaptic connections via reactivation of patterns of net

273 In addition, the number of synaptic connections was increased and astroglial synapt

274 ites and allowing probabilistic formation of synaptic connections, we reconstruct network connectivit

275 ay provide a mechanism that ensures that the synaptic connection weights in the sparse population of

276 We found that human synaptic connections were purely depressing and that the

277 s is thought to regulate the strength of the synaptic connection, which depends vitally on the number

278 inted via alteration of activity of a single synaptic connection, which in turn shapes experience-dep

279 ys provide the physical substrate to the new synaptic connection, while cell-cell signaling may provi

280 factory receptor neurons (ORNs) make precise synaptic connections with 50 classes of partner projecti

281 d along other dendrites to form strong multi-synaptic connections with a subset of partners.

282 he prefrontal cortex (PFC) exhibit extensive synaptic connections with deep layer neurons, implying t

283 , rod and cone photoreceptors form selective synaptic connections with different classes of bipolar c

284 n of AgRP fibers revealed direct, inhibitory synaptic connections with Kiss1(ARH) and Kiss1(AVPV) neu

285 es of NPY(+) (NPY(+) NGF) interneurones form synaptic connections with MSNs, although the strength of

286 nce that tank-expressing neurons form likely synaptic connections with neurons expressing the neural

287 tions and optogenetic interrogation of their synaptic connections with neurons in the basolateral amy

288 r cell have a greater probability of forming synaptic connections with one another and are biased to

289 tical (ClaC) projection neurons, rarely form synaptic connections with one another and are unlikely t

290 6s, and determine the presence or absence of synaptic connections with patch-clamp electrophysiologic

291 ansplanted rod precursors form classic triad synaptic connections with second-order bipolar and horiz

292 d in the extrastriate cortex where they form synaptic connections with spines and small-diameter dend

293 articularly diverse intrinsic properties and synaptic connections with the local network, suggesting

294 entral processes of primary nociceptors form synaptic connections with the second-order nociceptive n

295 icated in the response to hypoglycemia, make synaptic connections with the specific subset of glucore

296 at the MeApv mediates aggression priming via synaptic connections with the ventromedial hypothalamus

297 ually interconnected at random by excitatory synaptic connections (with a variable delay and a random

298 pses towards weakening, while preserving the synaptic connections within active neuronal assemblies.S

299 how that neurons can undergo injury at their synaptic connections within the gray matter, independent

300 y of novel mechanisms that establish precise synaptic connections within the nervous system.