ライフサイエンスコーパス: synaptic function

1 s in the context of cellular trafficking and synaptic function.

2 on of genes related to neural excitation and synaptic function.

3 +) channel levels are modulated to calibrate synaptic function.

4 emory, brain amyloidosis, tau pathology, and synaptic function.

5 tamatergic terminals, which is indicative of synaptic function.

6 s, and thus provide the structural basis for synaptic function.

7 fect between SZ eQTL genes that converges on synaptic function.

8 autophagy-mediated clearance mechanisms and synaptic function.

9 at affect CPG2 expression, localization, and synaptic function.

10 duce enduring changes in neural activity and synaptic function.

11 he short-term dynamics of mossy fibre to CA3 synaptic function.

12 ng is a critical player in the modulation of synaptic function.

13 l new insights into the principles governing synaptic function.

14 ecycling is essential for maintaining normal synaptic function.

15 rties consistent with possible photoreceptor synaptic function.

16 ulation, brain development and regulation of synaptic function.

17 d pathways relevant to neuronal survival and synaptic function.

18 of optogenetics to the molecular control of synaptic function.

19 ificantly enriched for genes associated with synaptic function.

20 f adolescent SHR and restored AMPAR-mediated synaptic function.

21 e encephalopathy, is required for inhibitory synaptic function.

22 a the endolysosomal pathway is essential for synaptic function.

23 es not impair axonal growth or signaling and synaptic function.

24 ering of cortical inputs as well as abnormal synaptic function.

25 of fueling presynaptic function to maintain synaptic function.

26 ne Phosphatase) is an important regulator of synaptic function.

27 hile Np65 is implicated in the regulation of synaptic function.

28 dendritic spines correlates with the loss of synaptic function.

29 ll excitability, two mechanisms required for synaptic function.

30 ociated with ligand receptor interaction and synaptic function.

31 ch has pleiotropic effects, in particular on synaptic function.

32 dwell time of many TM proteins important for synaptic function.

33 0 BDNF-coexpressed genes are associated with synaptic function.

34 e to long-term differences in CNS wiring and synaptic function.

35 The absence of both Cplxs perturbs ribbon synaptic function.

36 cesses to maintain neuronal excitability and synaptic function.

37 ceptors present in the hippocampus regulates synaptic function.

38 singly recognized as a critical regulator of synaptic function.

39 of how various alpha2delta proteins control synaptic function.

40 es with their ability to increase excitatory synaptic function.

41 ttle is known about how AD risk genes impact synaptic function.

42 -deficient mice, and restored NMDAR-mediated synaptic function.

43 l pathways related to neural development and synaptic function.

44 of SCZ by regulating neural development and synaptic function.

45 ered hippocampal-prefrontal connectivity and synaptic function.

46 hways previously implicated in addiction and synaptic function.

47 e significant effects on vesicle release and synaptic function.

48 in the heterozygous condition mediate normal synaptic function.

49 hildren with movement disorders by modifying synaptic function.

50 groups to proteins important for axonal and synaptic function.

51 reased synaptophysin expression and enhanced synaptic function.

52 rylation sites that can acutely regulate its synaptic function.

53 itical proteins that lead to modification of synaptic functions.

54 bit aberrant gene expression and deficits in synaptic functions.

55 oregulation of a subset of genes relevant to synaptic functions.

56 e of many genes, especially those regulating synaptic functions.

57 was "domesticated" in higher vertebrates for synaptic functions.

58 t collaborates with DKaiR1D to promote these synaptic functions.

59 on of gene sets associated with neuronal and synaptic functions.

60 of amyloidosis, immunity, mitochondrial, and synaptic functions.

61 iptional dysregulation, resulting in altered synaptic functions.

62 ers associated with abnormal development and synaptic functioning.

63 neurons in limbic cortical networks to alter synaptic functioning.

64 s fundamental property provides diversity of synaptic function across brain regions, but the source o

65 and supports a multi-level reorganization of synaptic function across the estrous cycle.

66 and cognitive deficits, and exhibit altered synaptic function across various brain areas.

67 grammed cell death, microtubule disassembly, synaptic function, aging, and insulin resistance, all pr

68 ssential not only in development but also in synaptic function and as key regulators of synapse forma

69 This work identifies clear alterations in synaptic function and behavior in a novel, genetically a

70 entification of new mechanisms that regulate synaptic function and behavior.

71 ice has revealed benefits of young plasma on synaptic function and behavior.

72 ssembly of a glycolytic metabolon to sustain synaptic function and behavior.

73 ts role in regulating neuronal excitability, synaptic function and brain disorders has only now begun

74 iments suggest that an age-dependent loss in synaptic function and Cdk5/p39 activity in the NAc may b

75 g use may modulate gene expression, altering synaptic function and circuit activity and leading over

76 tial to long-term depression, rescued normal synaptic function and cognition in cellular and animal m

77 that bioenergetic systems, important in both synaptic function and cognition, are abnormal in psychia

78 hat USP6 enhances NMDAR stability to promote synaptic function and cognition.

79 uired for normal habituation are enriched in synaptic function and converge on Ras/mitogen-activated

80 studied brain metabolism, a direct index of synaptic function and density, and neural connectivity t

81 e essential genes would significantly impair synaptic function and functional brain connectivity.

82 ific phenotype was accompanied by changes in synaptic function and gene expression selectively in fem

83 Developmental maturation of synaptic function and hearing were characterized in the

84 s study demonstrates a dual role of BRAG1 in synaptic function and highlights the functional relevanc

85 compartmentalization profoundly shapes both synaptic function and how that function can be assessed

86 energy metabolism is critical for supporting synaptic function and information processing.

87 ative phosphorylation can fuel low-frequency synaptic function and inhibiting both underlies loss of

88 epilepticus (SE), cause multiple changes in synaptic function and intrinsic properties of surviving

89 fied the physiological role of oAbeta(42) in synaptic function and memory formation providing solid f

90 r, this work reveals a novel role of HSF1 in synaptic function and memory, which likely occurs throug

91 Here, we use MEA-based assays to probe synaptic function and network interactions of hiPSC-deri

92 The dentate gyrus expressed synaptic function and neurogenesis genes correlated with

93 DEGs in the DG of middle-age rats, linked to synaptic function and neurogenesis, correlated with beac

94 cycling endosome function in AMPAR-dependent synaptic function and neuronal connectivity in vivo, and

95 regulation and those related to disorders of synaptic function and neuronal connectivity.

96 vide evidence that PLCgamma1 is critical for synaptic function and plasticity and that the loss of PL

97 that DCAF12 and Cul4 are critical for normal synaptic function and plasticity at larval NMJs.

98 a brain specific phosphatase that regulates synaptic function and plasticity by modulation of N-meth

99 strocytic calcineurin/NFATs helps to protect synaptic function and plasticity in an animal model in w

100 propose that the overall lack of changes in synaptic function and plasticity in DBN deficient mice m

101 aged-related and region-specific changes in synaptic function and plasticity in the aging brain.

102 LIS1 supports synaptic function and plasticity of mature CA1 neurons.

103 Synaptic function and plasticity were measured using ele

104 pse-to-nucleus signaling in neuron survival, synaptic function and plasticity, and memory.

105 with anti-NMDAR encephalitis alter neuronal synaptic function and plasticity, but the effects on oth

106 genes, from neural development and wiring to synaptic function and plasticity, energy balance, social

107 PRMT8 reveal multiple defects in excitatory synaptic function and plasticity.

108 tion, and deficiencies lead to reductions in synaptic function and plasticity.

109 molecular details of how fasting influences synaptic function and plasticity.

110 sents an unexplored regulatory mechanism for synaptic function and plasticity.

111 lting in hyperexcitability and impairment of synaptic function and plasticity.

112 ay alter Mef2a expression and thereby affect synaptic function and plasticity.SIGNIFICANCE STATEMENT

113 deletion of Arc/Arg3.1 before puberty alters synaptic function and prefrontal cortex activity.

114 se model of depression, at both the level of synaptic function and protein expression.

115 ndicate that PSD-95 deficiency disrupts mPFC synaptic function and related behavior at a critical age

116 sk gene for major mood disorders involved in synaptic function and related intermediate phenotypes.

117 erall treatment strategy for re-establishing synaptic function and restoring memory in patients with

118 CSP composition, including many CSPs without synaptic function and several that are uncharacterized.

119 area of Lnx1(-/-) mice rescues the defective synaptic function and social memory.

120 coupled, and their coupling is essential for synaptic function and structural stability.

121 ocampal slices to investigate adaptations in synaptic function and synaptic plasticity arising from a

122 intrahippocampal modulators in regulating SC synaptic function and the contributions of these modulat

123 teomics reveals protein networks involved in synaptic function and the etiology of neurodevelopmental

124 to neurodevelopment, neuronal excitability, synaptic function and the immune system in the pathogene

125 nactivation in rat neurons adversely affects synaptic function and thus may contribute to neuronal lo

126 pping neurodevelopmental modules involved in synaptic function and transcriptional regulation, with A

127 Mimicking changes in inhibitory synaptic function and transmembrane chloride regulation

128 a novel role for CDKL5 in the regulation of synaptic function and uncover an intriguing microcircuit

129 tic glutamate transporter EAAT2, influencing synaptic functioning and neural network activity.

130 are targeted to specific synapses, but their synaptic functions and mechanistic redundancy are not co

131 tructural dynamics of dendritic spines while synaptic functions and plasticity were measured via elec

132 as an enduring influence on gene expression, synaptic function, and cognition.SIGNIFICANCE STATEMENT

133 euronal d-serine is important in maintaining synaptic function, and deficiencies lead to reductions i

134 he brain that orchestrates neurodevelopment, synaptic function, and immune response to environmental

135 rocessing, compromise trophic signalling and synaptic function, and interfere with a neuron's ability

136 nt and the processes of chromatin structure, synaptic function, and neuron-glial signaling.

137 sion molecules regulate signal transduction, synaptic function, and plasticity.

138 bition of BACE1 on dendritic spine dynamics, synaptic functions, and cognitive performance of adult m

139 ates that the effects of ELS exposure on BLA synaptic function are sexually dimorphic and possibly re

140 Alterations of excitatory synaptic function are the strongest correlate to the pat

141 Disease-associated changes in synaptic functions are tightly correlated with altered m

142 regulate NPY release, and its effects on CA1 synaptic function, are not fully understood.

143 hich are mostly responsible for neuronal and synaptic functions, are highly enriched for FMRP binding

144 s complementarity extends to these proteins' synaptic function as well.

145 we also find that autophagy is essential for synaptic function, as light-activated damage to, for exa

146 s have implications in both the evolution of synaptic function, as well as the role of iGluRs in heal

147 hat Gbetagamma/SNAP-25 interactions regulate synaptic function at a ribbon-type synapse, contributing

148 JAK-STAT signaling also regulates excitatory synaptic function at the anatomically distinct temporoam

149 rough which group II mGlu receptors modulate synaptic function at the Schaffer collateral input to CA

150 s we study the DLG contribution to the basal synaptic-function at the Drosophila larval neuromuscular

151 l volumes of muscimol, which disrupts normal synaptic functions, before acute and repeated loud noise

152 activates a retrograde signal that restores synaptic function by adjusting neurotransmitter release.

153 that soluble Abeta oligomers interfere with synaptic functions by depleting NMDA-type glutamate rece

154 ment, glutamatergic/cholinergic/dopaminergic synaptic function, calcium and PI3K-AKT signaling.

155 ed by calmodulin activation, suggesting that synaptic function can be dynamically regulated.

156 beneficial effects on memory and hippocampal synaptic function can be reinstated by enhancing the exp

157 Dysfunction of the proteins regulating synaptic function can cause synaptic plasticity imbalanc

158 mbined application of both hormones provoked synaptic function collapse and spine disruption.

159 ic regions relative to somatic regions, with synaptic functions conserved in higher organisms.

160 ce, brain glucose uptake and metabolism, and synaptic function, could be preserved by the insulin-lik

161 es related to presynaptic neurotransmission, synaptic function, cytoskeletal rearrangements, energy m

162 impacts of TREM2 deficiency on cognitive and synaptic function during aging and suggest that TREM2 ma

163 ulation of neuronal and spine morphology and synaptic function during non-pathological aging which co

164 These data suggest that changes in synaptic function early in development caused by mutatio

165 d gene expression, indicating that restoring synaptic function early in the disease progression may r

166 BP2 in mice alters excitatory and inhibitory synaptic functions, engendering autistic-like behaviors.

167 rons to a less degenerative state, improving synaptic function, enhancing neuroprotective factors, an

168 e role of each of these genes in neuronal or synaptic function, evaluating the response of neuronal a

169 defects in endosomal trafficking that impair synaptic function, even in the absence of motor neuron c

170 ly within exons on transcripts that regulate synaptic function, excitatory synaptic transmission, and

171 aos in AD, while intracellular Abetaos alter synaptic function, extracellular Abetaos promote a vicio

172 o the long-term deficits in connectivity and synaptic function following early-life iron deficiency.

173 y excitatory synapses in the brain, changing synaptic function for several weeks after exposure.

174 of both Cplxs perturbs photoreceptor ribbon synaptic function; however, Cplx3/4 function in photorec

175 Pathways relevant to neuronal and synaptic function, immune signaling, and glucocorticoid

176 ent of in vitro methods that can investigate synaptic function in a high-throughput format could be h

177 trix directs synapse formation and regulates synaptic function in a model of human cortical brain dev

178 nd tau interdependently cause impairments in synaptic function in AD.

179 w loss of PS activity inhibits glutamatergic synaptic function in Alzheimer's disease patients.

180 roteins, which may contribute to the loss of synaptic function in Alzheimer's disease.

181 avage of tau at Asp314 impairs cognitive and synaptic function in animal and cellular models of tauop

182 ence has accumulated that autophagy controls synaptic function in both the axon and dendrite.

183 The importance of genes related to synaptic function in brain disease has been implied in s

184 ses to meet local energy demands and support synaptic function in Caenorhabditis elegans neurons.

185 islocating glutamate receptors and impairing synaptic function in cultured neurons, and it prevented

186 related to synaptic overgrowth, with reduced synaptic function in developing cortex in a regional-, e

187 r whether this innate property helps restore synaptic function in disease once the primary cause of d

188 aling cascade offers new avenues to modulate synaptic function in disease.

189 he presynaptic compartment but do not impair synaptic function in fly neurons.

190 rate that CDKL5 is an important regulator of synaptic function in glutamatergic neurons and serves a

191 tic response gone awry and underlie impaired synaptic function in HAND.

192 r juvenile mice only modestly impaired basal synaptic function in hippocampus and caused no alteratio

193 Vision loss also strengthened inhibitory synaptic function in L4 and L2/3 of A1, but via laminar

194 R1 driven changes in behavior and changes in synaptic function in layer 2/3 neurons in the PL, which

195 o examine roles of alpha2delta in excitatory synaptic function in male and female Cacna2d2 knock-out

196 ochemical approaches to assess cognitive and synaptic function in male and female young and aged TREM

197 edly critical for dendritic excitability and synaptic function in mature pyramidal neurons in additio

198 rugs and stress trigger divergent changes in synaptic function in NAc.

199 bution at postsynaptic densities and impairs synaptic function in neurons derived from human embryoni

200 gulates food intake by modulating excitatory synaptic function in neurons in the hypothalamus.

201 glutamate receptor expression and excitatory synaptic function in prefrontal cortex and hippocampus.

202 ophysiology and anatomical methods to assess synaptic function in Ptchd1-deficient dentate granule ce

203 ctrum disorders as well as in alterations in synaptic function in regions involved in social activity

204 tin state of subjects and restore memory and synaptic function in the aging brain.

205 cognition and decreases synapse numbers and synaptic function in the brain, thereby increasing the r

206 pport further exploration into their role in synaptic function in the brain.

207 de electrophysiological assessment of better synaptic function in the inhibitor-treated group.

208 (D(2)R-GSK-3beta(-/-)) in the brain affects synaptic function in the medial PFC (mPFC).

209 gnaling in mice, which subsequently increase synaptic function in the mPFC, and provide evidence for

210 s, PSD95, GluA1, and Synapsin 1 and enhanced synaptic function in the mPFC.

211 or increased levels of synaptic proteins and synaptic function in the mPFC.

212 ol-dependent D1R/mTORC1-mediated increase in synaptic function in the NAc may reflect a neural imprin

213 tin cytoskeleton, an organelle necessary for synaptic function in the presynaptic and postsynaptic co

214 What remains unknown is how EAAC1 shapes synaptic function in the striatum.

215 ritical regulator of axonal excitability and synaptic function in unmyelinated axons.SIGNIFICANCE STA

216 expression improves learning and memory and synaptic function in vivo AD mice, and alleviates Abeta-

217 CA1 synapse ultrastructural morphology, and synaptic functioning in adult C57BL/6J and DBA mice.

218 erentially impaired excitatory or inhibitory synaptic functions in an isoform-specific manner.

219 ce of drug abuse by influencing neuronal and synaptic functions in multifaceted ways.

220 abinoid degradation normalized behaviors and synaptic functions in n-3 PUFA-deficient adult mice.

221 key factors in development, neurogenesis and synaptic functions in the central nervous system.

222 ive and diverse roles in modulating neuronal/synaptic functions in the CNS.

223 ts suggest that WRB plays a critical role in synaptic functions in these two sensory cells, and that

224 ging mutations in genes that are critical to synaptic function, including neural circuitry mediated b

225 , OPHN1 has been reported to control several synaptic functions, including synaptic plasticity, synap

226 nt to many aspects of disrupted neuronal and synaptic function, increased permeability to inflammator

227 sma lipid levels can influence cognition and synaptic function independent of ApoE expression in the

228 ical and neurophysiological modifications in synaptic functions independently from age of disease ons

229 synapses are diminished, whereas inhibitory synaptic function is enhanced.

230 Moreover, the FAD mutation impairs synaptic function, learning and memory, and age-dependen

231 and control vesicle acidification and hence synaptic function, likely through regulation of the asse

232 se findings provide insights into how stable synaptic function may be maintained in the nervous syste

233 n brain and that genes encoding for neuronal synaptic function may be particularly sensitive to the a

234 ccumulating evidence suggests that APP has a synaptic function mediated by an unidentified receptor f

235 including neuronal electrical activity, pre-synaptic functions, MEK-ERK signaling, and axonal guidan

236 ingual central nervous tissue that underpins synaptic function, memory acquisition, and social behavi

237 (Abeta) are signaling molecules involved in synaptic function, memory formation and cognition, such

238 Disturbances of synaptic function might underlie abnormalities of neuron

239 CPTX restored synaptic functions, motor coordination, spatial and cont

240 DR) proteins are causally linked to abnormal synaptic function, neuronal growth and survival are unkn

241 In this study, we explore the synaptic function of A(2A)R in age-related conditions.

242 normalized glutamate receptor expression and synaptic function of gamma2(+/-) mice to wild-type level

243 Thus, the synaptic function of heteromeric receptors is likely to

244 treatment enhanced neurite total length and synaptic function of human neurons.

245 nslational target, which is required for the synaptic function of LRRK2.

246 ations in Nrxn1alpha surface trafficking and synaptic function of Mint2.

247 Our results described the synaptic function of neuroligin-2 in the LS, uncovered a

248 nPhys medium, previously reported to enhance synaptic function of neurons in culture, would accelerat

249 hts into the molecular mechanisms underlying synaptic functions of AMPAR-auxiliary subunit complexes.

250 gonism regulates TRN development, as well as synaptic functions of GABAergic motor neurons.

251 soform, we studied excitatory climbing fiber synaptic function onto PCs in Cacna2d2 KO mice.

252 focused on 3,087 candidate genes with known synaptic functions or prior evidence from genome-wide as

253 urden was enriched for genes associated with synaptic function (OR = 1.68, P = 2.8 x 10(-11)) and neu

254 ndamental role in ensuring normal and stable synaptic function, our findings suggest that aberrant fu

255 changes in the trajectory of microglial and synaptic function over the first two decades, and sugges

256 athways for glutamatergic neurotransmission, synaptic function, pain sensing, metalloproteinases, and

257 device array to emulate the light-adaptable synaptic functions (photopic and scotopic adaptation) of

258 S modulation and its impact on excitability, synaptic function, plasticity, and brain clearance requi

259 can regulate dendritic spine morphology and synaptic function, possibly via interaction with the Glu

260 e steps are linked to significant changes in synaptic function, potentially resulting in emergence an

261 A longitudinal gene cluster involved in synaptic function primarily drives the association with

262 e despite the improved learning behavior and synaptic function relative to controls with normal level

263 ose to autism, but how such mutations affect synaptic function remains incompletely understood.

264 el role for CC2D1A in regulating hippocampal synaptic function.SIGNIFICANCE STATEMENT CC2D1A is abund

265 roteins required for proper connectivity and synaptic function.SIGNIFICANCE STATEMENT Proper function

266 aintain not only synapse integrity, but also synaptic function.SIGNIFICANCE STATEMENT The real-time s

267 the former associated with inflammation and synaptic function similar to changes observed in human A

268 d with neurotrophins, programmed cell death, synaptic function, sirtuins and aging, and insulin resis

269 ice successfully demonstrates diverse visual synaptic functions such as phototriggered short-term pla

270 Evidence from research on both autophagy and synaptic function suggests that there are links between

271 atal day 0 (P0) or day 21 (P21) and measured synaptic function, synaptic plasticity and spine numbers

272 hippocampus and central amygdala, affecting synaptic function, systemic glucose homeostasis, behavio

273 alamus (PVN) found no significant changes in synaptic function that corresponded with the blunted HPA

274 trafficking and its role in maintaining the synaptic function that underlies higher cognitive proces

275 these zones is believed to be essential for synaptic function, the mechanisms controlling their mutu

276 iven the large number of proteins needed for synaptic function, the proliferation of defective protei

277 Given their effects on synaptic function, they might contribute to a broad spec

278 Somatodendritically released peptides alter synaptic function through a variety of mechanisms, inclu

279 talloproteinase 10 (ADAM10) is implicated in synaptic function through its interaction with postsynap

280 ng region Y-box 2, nestin, and also enhances synaptic function through upregulation of synaptophysin

281 n 2 (SV2) family of proteins are involved in synaptic function throughout the brain.

282 ll-regulated endocytosis, which is vital for synaptic function to recycle membrane and synaptic prote

283 of key elements of AD pathology and enhance synaptic functions to counteract oAbeta-induced synaptic

284 energy efficiencies, but they still lack the synaptic functions to facilitate concurrent convolutiona

285 Multiple forms of homeostasis influence synaptic function under diverse activity conditions.

286 To establish which synaptic functions unequivocally require neuroligins, we

287 oreover, while Abeta1-42 oligomers impact on synaptic function, vAbeta1-42 does not.

288 ignificantly contributed in the retention of synaptic functions (VGLUT1 and GAD65) in cerebellar neur

289 o the role of presenilins (PS) in excitatory synaptic function, we address the relevance of the prote

290 n/BLOC-1 participate in a pathway-regulating synaptic function, we examined the role for NSF in dysbi

291 AARs at synapses, GABAergic innervation, and synaptic function were reduced in GODZ KO and DKO neuron

292 vels, expression of presynaptic proteins and synaptic function were restored.

293 Finally, synaptic functions were characterized using electrophysi

294 biological processes, including neuronal and synaptic functions, were consistently associated with ge

295 for example, Synaptophysin only compromises synaptic function when autophagy is simultaneously block

296 y the morphological correlates of defects in synaptic function which may underlie motor impairments a

297 trocytic NRCAM markedly decreases inhibitory synaptic function, with minor effects on excitation.

298 onal autophagy in homeostatic maintenance of synaptic functions, with particular focus on how disrupt

299 moter-specific effects can drastically alter synaptic function within a specific region, without para

300 We hypothesized that NMJ synaptic functions would be altered precociously in an M