ライフサイエンスコーパス: synaptic input

1 ly, these properties reflect correlations in synaptic input.

2 ents (e.g., NMDAR-mediated Ca(2+) influx) by synaptic input.

3 a changing E/I ratio and the tuning of total synaptic input.

4 dendritic L-type channels amplify excitatory synaptic input.

5 elicits a paradoxical increase in inhibitory synaptic input.

6 nterneurons with a characteristic pattern of synaptic input.

7 autophagy for normal dendritic structure and synaptic input.

8 ns with the ability to receive and transform synaptic input.

9 t larger motor units receive more excitatory synaptic input.

10 , amplitude, duration, and shape of rhythmic synaptic input.

11 opographically ordered retinal ganglion cell synaptic inputs.

12 g the interplay of excitatory and inhibitory synaptic inputs.

13 riptive of the model's firing behavior under synaptic inputs.

14 n by responding preferentially to concurrent synaptic inputs.

15 s with single cells' spike outputs and their synaptic inputs.

16 ends action potential duration and increases synaptic inputs.

17 te kisspeptin neurons more sensitive to fast synaptic inputs.

18 oltage fluctuations reflects correlations in synaptic inputs.

19 ate consistently under the action of natural synaptic inputs.

20 ons by integrating excitatory and inhibitory synaptic inputs.

21 ptic neurons, boosting cooperativity between synaptic inputs.

22 rization, which boosts cooperativity between synaptic inputs.

23 erior olive actively integrate glutamatergic synaptic inputs.

24 ory can be tested experimentally by blocking synaptic inputs.

25 smaller spines and receive weaker excitatory synaptic inputs.

26 itability but also the temporal filtering of synaptic inputs.

27 ability to differentiate and receive normal synaptic inputs.

28 ing generated in an intrinsic manner without synaptic inputs.

29 t unbalancing of glutamatergic and GABAergic synaptic inputs.

30 compensatory adjustments in the strength of synaptic inputs.

31 receive inhibitory GABAergic and glycinergic synaptic inputs.

32 ed competition with mature granule cells for synaptic inputs.

33 s that receive and integrate most excitatory synaptic inputs.

34 exquisitely precise integration of binaural synaptic inputs.

35 ctivated, and they receive a distinct set of synaptic inputs.

36 ation, shortens spike duration and decreases synaptic inputs.

37 ike outputs from computationally integrating synaptic inputs.

38 pines that are strongly depolarized by their synaptic input, a process requiring a high spine neck re

39 ral computation relies on the integration of synaptic inputs across a neuron's dendritic arbour.

40 in output neurons of the cortex, integrating synaptic inputs across different cortical layers.

41 ar voltage integration, suggesting they pool synaptic inputs across their neuronal structures.

42 cumulated on trial-to-trial covariability in synaptic inputs activation, subthreshold membrane potent

43 Despite losing their main synaptic input, AII cells were not reduced in number, bu

44 t capture the local non-linear processing of synaptic inputs allowed for by dendrites.

45 Neurons receive a multitude of synaptic inputs along their dendritic arbor, but how thi

46 rporate two separate pathways for processing synaptic inputs: an already established dendrodendritic

47 ates NMDARs, even when the delay between the synaptic input and ADPs is relatively long (e.g., severa

48 1D channels, which activate upon cholinergic synaptic input and amplify EPSPs, thus indicating a cons

49 nonphysiological innervation receive similar synaptic input and could be voluntary controlled as moto

50 d that mutant neurons exhibit alterations of synaptic input and GABAB/GIRK signaling, reflecting a lo

51 tion and linearizes the relationship between synaptic input and neural output.

52 quently, their presence must influence their synaptic input and physiology.

53 itic spine stabilization depends on afferent synaptic input and requires changes in actin cytoskeleto

54 scene arises from the information encoded in synaptic input and shaped by postsynaptic signal integra

55 uli is a consequence of rectified excitatory synaptic input and that accounting for nonlinear spatial

56 of PNNs must have an important impact on the synaptic input and the physiology of PV+ cells.

57 But spatial correlations in synaptic input and those introduced by network connectiv

58 erial section electron microscopy to map 899 synaptic inputs and 623 outputs in one inhibitory intern

59 Modifications of synaptic inputs and cell-intrinsic properties both contr

60 ally modeling spike outputs from integrating synaptic inputs and comparing them with real spike respo

61 integrating a large number of male-specific synaptic inputs and conveying them to both male-specific

62 Neurons within clusters received stronger synaptic inputs and displayed increased membrane potenti

63 ndritic arbours and spine densities, general synaptic inputs and expression of specific glutamate rec

64 Here we investigate the interaction of local synaptic inputs and global activation of a neuron by a b

65 ed persistent plasticity of their excitatory synaptic inputs and hippocampal memory consolidation, un

66 the effects of trial-to-trial variability of synaptic inputs and intra-trial variability of thalamoco

67 ns are recruited systematically according to synaptic inputs and intrinsic cellular properties and co

68 nt firing rates reflect interactions between synaptic inputs and intrinsic currents.

69 process, we studied the interaction between synaptic inputs and intrinsic properties using whole-cel

70 e typically achieved during response to fast synaptic inputs and membrane capacitance.

71 Here we image the excitatory synaptic inputs and outputs of retinal ganglion cells to

72 temporal components due to ongoing activity, synaptic inputs and recurrent connectivity.

73 ich neurones in the inferior olive integrate synaptic inputs and the roles of particular ion channels

74 es orientation selectivity of the inhibitory synaptic inputs and the spiking responses.

75 excitability regulates how neurons integrate synaptic inputs and thereby influences neuronal output.

76 terogeneous; subpopulations receive distinct synaptic inputs, and project to anatomically and functio

77 d by both action potentials and subthreshold synaptic inputs, and that conversion level is correlated

78 te nuclear calcium transients in response to synaptic inputs, and the subsequent induction of express

79 ic sites that receive most of the excitatory synaptic inputs, and thus provide the structural basis f

80 a(2+)channels and NMDA receptors occurs when synaptic inputs are either clustered onto individual den

81 How synaptic inputs are functionally organized at the subcel

82 uts drive neuronal selectivity, whereas weak synaptic inputs are less correlated with the somatic out

83 Therefore, early synaptic inputs are powerfully converted into reliable s

84 ous firing is that excitatory and inhibitory synaptic inputs are precisely correlated, nearly canceli

85 revealed that both excitatory and inhibitory synaptic inputs are strongly inhibited by GABA(B)Rs, whi

86 tracellular transformation of information as synaptic inputs are translated into action potentials.

87 neurons, and mGluR-dependent tetanization of synaptic input - are separate pathways that converge at

88 ns across all subject groups received common synaptic input as identified by coherence analysis of th

89 ing activity of VP neurons in the absence of synaptic inputs as neither the mean intraburst frequency

90 changes that preserved the fraction of total synaptic input associated with each pre-synaptic partner

91 Additionally, the persistence of substantial synaptic input at least to P60 suggests that this pathwa

92 anule cell number, morphology and excitatory synaptic inputs at 7 dpi are modified by voluntary wheel

93 ligands, which is required for formation of synaptic inputs at specific dendritic localizations.

94 Excitatory synaptic inputs, but not inhibitory synaptic inputs, wer

95 ies suggest that MOC neurons receive diverse synaptic inputs, but the functional effect of additional

96 turn modulated by the organization of their synaptic inputs, but the principles governing the develo

97 th models that predict active integration of synaptic inputs by inferior olive neurones, we find that

98 Subsets of synaptic input can be selected or 'gated' by precise mod

99 show how, via this D2R-dependent phenomenon, synaptic input can enhance the excitability of prefronta

100 Strong, sparse synaptic inputs can be distinguished by their amplitudes

101 efficient integration of subthreshold distal synaptic inputs compared with the same cell type in sens

102 cting the coincidence of binaural excitatory synaptic inputs distributed along the dendrites.

103 the prediction that a small number of strong synaptic inputs drive neuronal selectivity, whereas weak

104 omuscular activity and elimination of excess synaptic input during development.

105 ting MN morphology and glutamatergic central synaptic inputs during late embryonic development.

106 These results suggest an emergence of novel synaptic inputs during MD that disrupt the representatio

107 will be non-linear dendritic integration of synaptic inputs during synchronous activation.

108 We found that synaptic input (either excitatory, inhibitory, or both)

109 IFICANCE STATEMENT Persistent alterations in synaptic input elicit homeostatic plastic changes in neu

110 The direct inhibitory synaptic input engages mitral cell intrinsic membrane pr

111 s of abstinence, and then recorded GABAergic synaptic input evoked either electrically or optogenetic

112 mporal profiles of excitatory and inhibitory synaptic inputs evoked by the same sound stimuli in laye

113 s permissive for the efficient generation of synaptic input-evoked nuclear calcium transients driving

114 that the control of motor neurons and their synaptic input, following reinnervation, was remarkably

115 and require coincident timing of excitatory synaptic inputs for the generation of dendritic plateau

116 orm scaling of quantal amplitudes across all synaptic inputs formed on neurons, as well as on the pos

117 reactive puncta suggesting that they receive synaptic input from bipolar cells.

118 releasing peptide (Grp), that receive direct synaptic input from both pain and itch primary sensory n

119 t one projection neuron type received direct synaptic input from both temperature and dry-air glomeru

120 bipolar cells are interneurons that receive synaptic input from cone photoreceptor cells and provide

121 Individual RGC types receive synaptic input from distinct presynaptic circuits; there

122 these cells receive much of their excitatory synaptic input from MrgA3/MrgD-expressing nociceptive/pr

123 served that clonally related neurons receive synaptic input from olfactory sensory neurons expressing

124 vity is mainly a consequence of an increased synaptic input from osmoresponsive neurons in regions ad

125 ignificant change in area postrema volume or synaptic input from PHOX2B-derived neurons.

126 Purkinje cells receive synaptic input from several classes of interneurons.

127 tergic warm-sensing POA neurons that receive synaptic input from several thermoregulatory nuclei.

128 s was found, there was no evidence of direct synaptic input from the basal forebrain.

129 It was shown that nerve injury strengthens synaptic input from the BLA onto inhibitory interneurons

130 expectedly long dendrites, which may receive synaptic input from the cerebral cortex and other brain

131 and the isthmic complex that receives strong synaptic input from the ICX and projects broadly upon th

132 esentations of odors in DG GCs that required synaptic input from the LEC.

133 Np13 neurons respond to male song via direct synaptic input from the pC2l auditory neurons.

134 t the lateral habenula (LHb) receives direct synaptic input from the PFC and that activation of LHb n

135 luctuations are driven by the convergence of synaptic inputs from a diverse cross-section of upstream

136 Pyramidal neurons integrate synaptic inputs from basal and apical dendrites to gener

137 aneous mechanical stimuli and receive strong synaptic inputs from both high- and low-threshold primar

138 omuscular circuit, where the muscle receives synaptic inputs from different motoneurons.

139 s are matched to dendrite size, and by which synaptic inputs from different transmitter systems are c

140 We propose that dFB neurons integrate synaptic inputs from distinct sets of upstream sleep-pro

141 ctively decreased spine numbers and impaired synaptic inputs from entorhinal but not Schaffer-collate

142 Sensitization is present in the excitatory synaptic inputs from midget bipolar cells and is mediate

143 ectivity both from excitatory and inhibitory synaptic inputs from other neurons and from their own in

144 are input-output (I/O) devices-they receive synaptic inputs from other neurons, integrate those inpu

145 city mechanisms involving the enhancement of synaptic inputs from spared axon populations is a powerf

146 Thus enhancing GABAergic inhibitory synaptic inputs from SST(+) interneurons to pyramidal ce

147 neurons (SPNs) receive convergent excitatory synaptic inputs from the cortex and thalamus.

148 eralization and receives enhanced excitatory synaptic inputs from the medial entorhinal cortex, which

149 Here, we obtained spike outputs and synaptic inputs from the same neurons within characteris

150 uditory cortex neurons nonlinearly integrate synaptic inputs from the thalamus and cortex, and genera

151 nt actions serve as important integrators of synaptic inputs from upstream centers, including the bas

152 By solving an inverse problem to uncover synaptic inputs from Ve patterns we provide a new perspe

153 all, these results indicate that spontaneous synaptic inputs generate a low-conductance state in whic

154 ed long-term plasticity of nearby excitatory synaptic inputs has been proposed to shape experience-re

155 mbine the integration of local and extrinsic synaptic input in a nuanced, region-specific manner.SIGN

156 d an increase in amplitude of the inhibitory synaptic input in cerebellar Purkinje cells.

157 that were associated with greater excitatory synaptic input in females.

158 tory synchrony is evident in the spontaneous synaptic input in mitral cells (MCs) separated up to 220

159 ly encode high-frequency components of their synaptic input in output spike trains.

160 assess intrinsic excitability and functional synaptic input in spiny projection neurons (SPNs) and fa

161 Active amplification of organized synaptic inputs in dendrites can endow individual neuron

162 By contrast, stimulation of synaptic inputs in the RVLM decreased GABAergic inhibiti

163 of neurotransmitter release from the active synaptic inputs in the RVLM produced saturation of GABAe

164 on intrinsic excitability, in the absence of synaptic input, in hippocampal CA3 neurons, a classical

165 The proportion of dendrites with synaptic input increased from 50% to 80% by 6 months.

166 hibitory Dmrt3-Cre neurons receive extensive synaptic inputs, innervate surrounding CPG neurons, intr

167 ase neuronal gain, i.e., the conversion of a synaptic input into a firing output.

168 ic tree receives, propagates, and transforms synaptic inputs into action potential output.

169 garding the spatial distribution of thalamic synaptic inputs into layer 4, the model predicted charac

170 putation they perform is clear: they convert synaptic inputs into spatially modulated, periodic firin

171 ugh these properties reflect correlations in synaptic inputs, intrinsic membrane properties often ind

172 ctive ganglion cells (ON-OSGCs) reveals that synaptic input is mediated almost exclusively through th

173 simple model in which a fraction of the pre-synaptic input is silenced can reproduce this reduction

174 Precise timing of synaptic inputs is a fundamental principle of neural cir

175 The level of conversion by subthreshold synaptic inputs is correlated to the strength of input,

176 dence detection of excitatory and inhibitory synaptic inputs is essential for LSO neurons to encode b

177 lar excitability in a manner that depends on synaptic input, is mediated at the cellular level throug

178 determined largely by the number and type of synaptic inputs it receives, and these, in turn, are gre

179 bility is presumed to arise from overlapping synaptic input, its precise relationship to local circui

180 y in which the cell body integrates proximal synaptic inputs, leading to spike generation in the prox

181 Therefore, synaptic input locally directs dendrite growth, but intr

182 SCG2-dependent reorganization of inhibitory synaptic input might be predicted to affect network func

183 Further, blocking synaptic inputs minimally altered somatic membrane resis

184 Analysis of over 100,000 synaptic input neurons demonstrated that cocaine-activat

185 We examined the synaptic inputs of age-defined populations of DGCs using

186 dy the dynamics of excitatory and inhibitory synaptic inputs of each neuron.

187 n identified Drosophila neuron, we show that synaptic inputs of two different transmitter classes loc

188 ge GABAergic projections provide a prominent synaptic input on granule and short axon cells in deep l

189 Synaptic inputs on dendrites are spatially clustered by

190 sor in awake monkeys, and map the excitatory synaptic inputs on dendrites of individual V1 superficia

191 Neurons receive synaptic inputs on extensive neurite arbors.

192 begun to outline the spatial organization of synaptic inputs on individual neurons, the underlying pr

193 eflects directly the functional influence of synaptic inputs on somatic membrane potential dynamics,

194 and a deficit in the formation of excitatory synaptic inputs on to these neurons in neonatal Fmr1 KO

195 reversible method for modulating inhibitory synaptic input onto genetically determined cells.

196 convergence of muscle and cutaneous afferent synaptic input onto individual projection neurons.

197 sely corresponds to the physical location of synaptic input onto its dendrites, a relationship called

198 ic spines are the primary site of excitatory synaptic input onto neurons, and are biochemically isola

199 orporated biological detail using sequential synaptic input onto spines in morphologically, electrica

200 on of any neuron is to uncover the source of synaptic input onto the cell, its intrinsic physiology a

201 d rabies virus evidence was found for direct synaptic input onto V1 inhibitory neurons.

202 ion, may reflect near-synchronous excitatory synaptic inputs onto cortical pyramidal neurons.

203 el indicates that the spatial arrangement of synaptic inputs onto dendrites could play a significant

204 The integration of synaptic inputs onto dendrites provides the basis for ne

205 reorganizations of excitatory and inhibitory synaptic inputs onto glutamatergic and GABAergic neurons

206 ncreased excitatory and decreased inhibitory synaptic inputs onto granule cells of Pafah1b1(+/-) mice

207 ones suppress both excitatory and inhibitory synaptic inputs onto layer 2/3 cells ("network suppressi

208 opment of local versus long-range excitatory synaptic inputs onto layer 2/3 neurons in the somatosens

209 Emerging evidence suggests that central synaptic inputs onto motor neurons (MNs) play an importa

210 io of the overall excitatory over inhibitory synaptic inputs onto NAc principle neurons after SDe.

211 , NMDAR signaling via activity of long-range synaptic inputs onto neurogliaform cells is required for

212 ortical plasticity by controlling excitatory synaptic inputs onto PV neurons and thus PV-cell mediate

213 Both reduction of GABA release and synaptic inputs onto pyramidal cells erode the emergence

214 For a significant fraction of TRN neurons, synaptic inputs or brief depolarizing current steps led

215 These experiments show that integration of synaptic inputs over time by Nav1.7 is critical for body

216 determine plasticity of different excitatory synaptic input patterns in perisomatic dendrites of CA1

217 a the combination of dendritic processing of synaptic input patterns with long-term synaptic plastici

218 the structural organization of PNNs and the synaptic inputs perforating them in primary visual corte

219 Alterations in synaptic input, persisting for hours to days, elicit hom

220 The results also indicate that the synaptic inputs received by the motor neurons before for

221 ct with subsequent excitatory and inhibitory synaptic inputs remains unknown.

222 Loss of inhibitory synaptic input resulted in increased excitability of SST

223 Analysis of the synaptic inputs shows that this saccadic suppression res

224 and K(+) conductances suppress low-frequency synaptic inputs, so cells with larger voltage-gated cond

225 generate local action potentials (APs) upon synaptic input ("spine spike").

226 ctivity driven by stochastic spatio-temporal synaptic input streams in these structures has presented

227 KO mice showed a greatly enhanced excitatory synaptic input strength in neurons of the lateral superi

228 Therefore, our study on spontaneous synaptic inputs suggests a different extent of synaptic

229 Neurons outside clusters had weaker synaptic input than neurons within clusters, in which in

230 erent pyramidal neuron subtypes also receive synaptic inputs that are dissimilar in frequency and in

231 porally structured excitatory and inhibitory synaptic inputs that are driven by ipsi- and contralater

232 cortex (PFC) inputs revealed a hierarchy of synaptic inputs that depends on the identity of the post

233 ion conductances, inhibitory and excitatory synaptic inputs that differ among this cell population.

234 The goal of this study was to describe the synaptic inputs that shape the light responses of the ON

235 otion, stops ongoing locomotion by providing synaptic inputs that trigger the termination burst in st

236 als in a pacemaker pattern in the absence of synaptic input, the intrinsic properties that underlie t

237 delity is thought to depend on the GABAergic synaptic input through a feedforward inhibitory circuit

238 mechanisms best tuned to temporal pattern of synaptic input to achieve long-lasting LTP and memory st

239 neonatal surgical injury on primary afferent synaptic input to adult mouse SDH interneurons using in

240 natomy with targeted genetic manipulation of synaptic input to an identified Drosophila neuron, we sh

241 ediate separate components of the excitatory synaptic input to AOFF-S RGCs.

242 First, we identify robust, excitatory synaptic input to Bar.

243 eurons, it is proposed that this occurs when synaptic input to cortex is strong yet decorrelated.

244 results provide the first evidence that late synaptic input to corticospinal neurons may represent a

245 t force coordination patterns, we found that synaptic input to motor neurons is shared across all fre

246 to muscles and therefore to infer sources of synaptic input to motor neurons.

247 ll signaling in shaping the excitability and synaptic input to motor neurons.SIGNIFICANCE STATEMENT W

248 ze densely in the ARC and provide inhibitory synaptic input to nearby anorexigenic POMC neurons.

249 tral retina form clusters, which may augment synaptic input to SCBCs.

250 In CA1, both synaptic input to single neurons and population activity

251 we determined the neuronal classes providing synaptic input to the CSDns within the antennal lobe (AL

252 t function may be attributable to changes in synaptic input to the motor neuron pool or to adaptation

253 low contraction levels and/or strong common synaptic input to the motor neurons.

254 phroditic marine-snail, Aplysia californica, synaptic input to the neuroendocrine bag cell neurons tr

255 two hand muscles are concurrently activated, synaptic input to the two motor neuron pools is shared a

256 he identity of upstream neurons that provide synaptic input to this subpopulation is unclear.

257 rotransmission in which the strengths of all synaptic inputs to a cell are multiplicatively scaled up

258 We found that the excitatory synaptic inputs to both orexin- and melanin-concentratin

259 othesized that BOLD reflects the strength of synaptic inputs to cortex, whereas NBG is more dependent

260 In vitro work revealed that excitatory synaptic inputs to hippocampal inhibitory interneurons c

261 rate, interspike intervals and estimates of synaptic inputs to motor neurons were assessed.

262 ons also included interneurons that provided synaptic inputs to motor neurons, but the pharmacologic

263 pects of inferred inputs are consistent with synaptic inputs to MSO neurons including the tendencies

264 elective targeting of glycinergic inhibitory synaptic inputs to ON-DSGCs.

265 afferents, we identified extensive afferent synaptic inputs to OPCs residing in secondary motor cort

266 rely on synaptic plasticity, particularly at synaptic inputs to Purkinje cells.

267 reactive for calbindin, that likely underlie synaptic inputs to specific types of calretinin-immunore

268 ON cell loses proportionately more SNR from synaptic inputs to spike output than the OFF cell does.

269 Through EM reconstruction of all LC6 synaptic inputs to the glomerulus, we found that LC6 and

270 te that optogenetically activated long-range synaptic inputs to the inferior olive, including project

271 s increases in a neuron's spiking output and synaptic inputs to the nucleus, enabling gene regulation

272 otropin-releasing hormone (GnRH) neurons and synaptic inputs to these cells coincident with productio

273 o examine whether changes in the strength of synaptic inputs to these circuits contribute to this imb

274 l ganglion cells with overlapping excitatory synaptic input (transient Off alpha, transient Off mini,

275 es.SIGNIFICANCE STATEMENT The climbing fiber synaptic input transiently depolarizes the dendrite of c

276 cally attributed to an increase in GABAergic synaptic input triggered by non-preferred stimuli.

277 nally, we examined spiking and motor-related synaptic inputs using intracellular recordings during si

278 a neuron's action potential (AP) output and synaptic inputs, via excitatory postsynaptic potentials

279 The potentiated synaptic input was not initially coincident with action

280 In dendritic spines receiving synaptic inputs, we show here that in the presence of a

281 Using simulated GABA and glutamate synaptic inputs, we showed changes in both the passive a

282 Neurons store information by changing synaptic input weights.

283 inal dendritic branches, and total number of synaptic inputs were accompanied by cell type-specific c

284 parasol cells were reconstructed, and their synaptic inputs were analyzed.

285 l, visually evoked excitatory and inhibitory synaptic inputs were potentiated by visual experience an

286 Synaptic inputs were reliably induced by repetitive stim

287 evoked LFP spectral densities, indicative of synaptic inputs, were also 2-3-fold greater in dominant

288 citatory synaptic inputs, but not inhibitory synaptic inputs, were decreased in Foxp2(+/R552H) mice.

289 These D2R-induced ADPs only occur following synaptic input, which activates NMDARs, even when the de

290 to light decrements; and (5) distribution of synaptic inputs, which generate a color-opponent recepti

291 ain's own subsampling method (convergence of synaptic inputs) while extending the range of fundamenta

292 states promote the weakening of subthreshold synaptic inputs, while suprathreshold inputs are preserv

293 enshaw cells received spontaneous inhibitory synaptic input with a reduced frequency, showed lower in

294 uch phase maintenance requires adjustment of synaptic input with network frequency, a relationship th

295 y an increase of amplitude and peak phase of synaptic input with period.

296 dritic domains receiving distinct excitatory synaptic inputs with specific properties and plasticity

297 o estradiol treatment affect the response to synaptic inputs, with capacitance having a greater effec

298 Active integration of synaptic input within the inferior olive may play a cent

299 stence of a scaffold of neurons that receive synaptic inputs within the rat, mouse, and human fetal R

300 s selectively inhibit dendrites and regulate synaptic inputs, yet their response to systemic NMDAR an