ライフサイエンスコーパス: synaptic membrane

1 the CTL centrosome to a position beneath the synaptic membrane.

2 l nitric oxide synthase (nNOS) from the post-synaptic membrane.

3 acetylcholine receptors (AChRs) at the post-synaptic membrane.

4 zation of numerous signaling proteins in the synaptic membrane.

5 sis for activity-associated replenishment of synaptic membrane.

6 tion, thus inhibiting their recycling to the synaptic membrane.

7 boutons, indicating an inability to retrieve synaptic membrane.

8 PICK1-dependent transport of GluR2 from the synaptic membrane.

9 ustering or a selective stabilization in the synaptic membrane.

10 indicating enhanced organisation of the post-synaptic membrane.

11 by the movement of receptors to and from the synaptic membrane.

12 er by opening an ion channel across the post-synaptic membrane.

13 ology categories, such as dynein complex and synaptic membrane.

14 he functional signaling nanostructure of the synaptic membrane.

15 ecular organization and stability within the synaptic membrane.

16 from the subsynaptic nuclei to the overlying synaptic membrane.

17 ic interactions with the lipid matrix of the synaptic membrane.

18 phatidylinositol trisphosphate (PIP3) in the synaptic membrane.

19 ultiple protein kinase (PK)C isozymes to the synaptic membrane.

20 and Rab4-mediated recycling of AMPARs to the synaptic membrane.

21 a reduced rate of recycling of internalised synaptic membrane.

22 to vesicles immediately adjacent to the post-synaptic membrane.

23 by Rab8, drives receptor insertion into the synaptic membrane.

24 mediated by reverse signaling into the post-synaptic membrane.

25 on clusters of interacting receptors in the synaptic membrane.

26 in clustering the transmembrane proteins in synaptic membranes.

27 low values, such as in synaptic vesicles or synaptic membranes.

28 0.2 +/- 1.8%, respectively, of that in crude synaptic membranes.

29 ween the two processes typically observed in synaptic membranes.

30 a KD value (12 nM) which was 9-fold that for synaptic membranes.

31 other constituents of Torpedo electric organ synaptic membranes.

32 s alpha1 and alpha7 integrins are present in synaptic membranes.

33 ecessary to maintain normal levels of AP2 on synaptic membranes.

34 lesterol, an astrocyte-supplied component of synaptic membranes.

35 ution tomography and microtransplantation of synaptic membranes.

36 of NMDA receptors to both extrasynaptic and synaptic membranes.

37 y of alkylphenol-based anesthetic binding to synaptic membranes.

38 ion of lipid composition and organization in synaptic membranes.

39 g PDE10A to a specific functional context at synaptic membranes.

40 on is particularly reduced in frontal cortex synaptic membranes.

41 s to exocytosis of GluN1-GluN2B receptors to synaptic membranes.

42 s system, particularly in photoreceptors and synaptic membranes.

43 zing phosphatides, the major constituents of synaptic membranes.

44 elial cells, cultured neurons, and rat brain synaptic membranes.

45 te-containing phosphatidylcholine species in synaptic membranes, a finding with as yet uncertain sign

46 N-cadherin may reflect dynamic regulation of synaptic membrane adhesion, which, in turn, might modula

47 ilitated by PKA activation, SK2 recycling to synaptic membranes after TBS is inhibited by Ube3a.

48 ubcellular fractionation was used to isolate synaptic membranes; alternatively, membrane receptors we

49 plays a critical role in stabilizing AP2 on synaptic membranes, an event that is required for initia

50 f proteins that target NMDA receptors to the synaptic membrane and couple it to numerous signal trans

51 rm depression by stabilizing cadherin at the synaptic membrane and impairing AMPA receptor endocytosi

52 ional human NMJs that evidence pre- and post-synaptic membrane and motor nerve axon co-localisation.

53 function as cell-adhesion molecules at post-synaptic membrane and play critical roles in synaptogene

54 cluding components of the basal lamina, post-synaptic membrane and post-synaptic cytoskeleton.

55 bution studies show that SALM1 is present in synaptic membrane and postsynaptic density fractions but

56 of developmental remodeling in reconstituted synaptic membranes and observe remarkably stable microdo

57 ion of STEP prevents the loss of NMDARs from synaptic membranes and reverses behavioral deficits in N

58 4.16; Nln) was first identified in rat brain synaptic membranes and shown to ubiquitously participate

59 ieves this by limiting NMDAR availability at synaptic membranes and stabilizing spine actin cytoskele

60 nal transit through the actin-rich IS to the synaptic membrane, and can be defective in the context o

61 by the insertion of AMPAR subunits into the synaptic membrane, and we found that repeated systemic a

62 of receptors occurs at both synaptic and non-synaptic membranes, and glutamate receptors can exchange

63 Mammalian synaptic membranes appear to contain high proportions of

64 t target AMPA receptors for removal from the synaptic membrane are incompletely understood.

65 utamate-binding protein complex in rat brain synaptic membranes are described.

66 the fusion of neurotransmitter vesicles with synaptic membranes, are also needed for the prior tether

67 drebrin A in 2xKI mice was located near the synaptic membrane, as compared to those of WT mice.

68 ed due to increased levels of both total and synaptic membrane-associated dopamine transporters.

69 s, but not NMDARs, cycle into and out of the synaptic membrane at a rapid rate and that certain forms

70 pha-synuclein, AP2, and AP180 share a common synaptic membrane binding pathway.

71 STX-3 is a synaptic membrane-bound protein involved in the effects

72 laced nearly all of the [35S]TBPS binding to synaptic membranes but had no effect on binding to coate

73 tion may underlie the removal of AMPARs from synaptic membrane by Abeta.

74 retion of lysosomes, which are guided to the synaptic membrane by centrosome repositioning, can facil

75 ectodomain, which is released from the post-synaptic membrane by the SUP-17/ADAM10 protease.

76 ilar to corresponding structures observed in synaptic membranes can be generated on protein-free lipo

77 Relative to the levels in synaptic membranes, CCVs contained 110 +/- 14% and 29.5

78 w affinity phencyclidine-binding entity in a synaptic membrane complex.

79 demonstrate that a treatment that increases synaptic membrane content can enhance cognitive function

80 ransport of NMDA receptors in and out of the synaptic membrane contributes to several forms of long-l

81 HIV-1 Tat protein can damage the synaptic membranes contributing to the development of de

82 rch3.0, eNpHR3.0) tools to create a slow non-synaptic membrane current in bystander neurons, which ma

83 slices with Tat-H-Ras depleted NR2A from the synaptic membrane, decreased endogenous Src activity and

84 glutamatergic terminals display asymmetrical synaptic membrane densities with postsynaptic dense bodi

85 pleomorphic synaptic vesicles and symmetric synaptic membrane densities.

86 tic cell adhesion molecule Fasciclin II, and synaptic membrane detachment at active zones.

87 f vesicles containing TCRzeta and LAT at the synaptic membrane determines not only the nanoscale orga

88 e quantify the comprehensive lipidome of rat synaptic membranes during postnatal development and obse

89 2+)-sensors synaptotagmin-1 and Doc2b deform synaptic membranes during synaptic vesicle exocytosis.

90 ab3A has been postulated to cycle on and off synaptic membranes during the course of neurotransmissio

91 and of proteins that are concentrated within synaptic membranes (e.g., PSD-95, synapsin-1), improved

92 -ir (i.e., within 60 nm of the pre- and post-synaptic membranes), E treatment increased synaptic ERbe

93 a key omega-3 polyunsaturated fatty acid in synaptic membranes, enhances the agonist-induced transit

94 when the plasma membrane was separated into synaptic membrane-enriched and extrasynaptic membrane-en

95 ased throughout the neuron, including in the synaptic membrane-enriched fraction.

96 1 on GluR1 was decreased specifically in the synaptic membrane-enriched fraction.

97 RIMS2 regulates synaptic membrane exocytosis.

98 d by approximately 100%; (ii) similarly, the synaptic membrane expression of the alpha1 subunit prote

99 aminobutyric acid receptor regulation in the synaptic membrane fraction of the rat mPFC following ext

100 on of pp60c-src with insulin receptor in the synaptic membrane fraction, however, was temporally decr

101 d with its tyrosine dephosphorylation in the synaptic membrane fraction.

102 ation of IR protein in the hippocampal crude synaptic membrane fraction.

103 Orb2A is also found enriched in the synaptic membrane fraction.

104 the microsomal fraction but insoluble in the synaptic membrane fraction.

105 oligomers, and oligomers are enriched in the synaptic membrane fraction.

106 of Shc-66, Shc-52, and Grb-2 in hippocampal synaptic membrane fractions following training.

107 luble in Triton X-100 in both microsomal and synaptic membrane fractions, while NR1 was readily solub

108 in coimmunoprecipitates with syndecan-2 from synaptic membrane fractions.

109 brane fusion is constitutively active, while synaptic membrane fusion is regulated, consistent with t

110 this process is implicated in regulation of synaptic membrane fusion that may be altered by aggregat

111 Syntaxin 1, an essential protein in synaptic membrane fusion, contains a helical autonomousl

112 nts of the protein machinery responsible for synaptic membrane fusion.

113 For [3H]flunitrazepam binding to synaptic membranes, GABA gave an EC50 = 2.0 microM and a

114 Mechanisms that target PSD-95 to synaptic membranes, however, are unknown.

115 DiTC binding to human brain synaptic membranes identifies channels composed of other

116 (AMPARs) from dendritic compartments to the synaptic membrane in response to neuronal activity is a

117 show that alpha-synuclein binds to isolated synaptic membranes in an ATP-dependent manner, similar t

118 interaction of the peptidic conantokins with synaptic membranes in conjunction with a high affinity b

119 ulin also can cause Rab3A to dissociate from synaptic membranes in vitro.

120 been shown to cause Rab3A to dissociate from synaptic membranes in vitro.

121 Rs1 was associated with the outer surface of synaptic membranes in wild-type (Wt) retinas.

122 Rab8 is localized in close proximity to the synaptic membrane, including the postsynaptic density.

123 hain and the large GTPase dynamin-1, bind to synaptic membranes independent of ATP.

124 erved a specific reduction in AP2 binding to synaptic membranes, indicating that alpha-synuclein inte

125 that transports phosphatidylserine from the synaptic membrane inner to outer leaflet, and demonstrat

126 , long-term depression (LTD) promoted ADAM10 synaptic membrane insertion and stimulated its activity.

127 MPA-type glutamate receptors (AMPARs) to the synaptic membrane is a key mechanism to determine the st

128 ivery of neurotransmitter receptors into the synaptic membrane is essential for synaptic function and

129 CLASP2-mediated microtubule capturing at the synaptic membrane is essential for the maintenance of a

130 e binding of [(3)H]flumazenil to hippocampal synaptic membranes is decreased.

131 dopamine D4 receptor (hD4R) is maintained in synaptic membranes is not known.

132 f these processes by proteomically analyzing synaptic membranes lacking the synaptogenic adhesion mol

133 ation of NR2A and retention of NR2A into the synaptic membrane leading to inhibition of NMDA receptor

134 ARs) from Rab11-recycling endosomes into the synaptic membrane, leading to synaptic potentiation.

135 olumns that had been loaded with solubilized synaptic membranes; lesser concentrations of three polyp

136 ber of factors, including stimulus strength, synaptic membrane noise and especially whether or not th

137 forms protein accumulations that localize to synaptic membranes, nuclei and endosomes.

138 cellular fractions, homogenate, cytosol, and synaptic membranes, obtained from F344/BNF1 rats of 5-6,

139 show that APP/Bri2 complexes are reduced in synaptic membranes of FDD(KI) mice.

140 d enriched progressively in synaptosomes and synaptic membranes of sheep brain, as assessed by immuno

141 s are relatively fixed, AMPA receptors cycle synaptic membranes on and off.

142 owed up-regulation of multiple pre- and post-synaptic membrane or scaffolding proteins including glut

143 ent the structural abnormalities of the post-synaptic membrane or the abnormal oxidative properties o

144 s by which clathrin-coated vesicles retrieve synaptic membranes or take up endocytic receptors have b

145 aptically, being frequently localized on the synaptic membranes or the synaptic junctional complex.

146 the postsynaptic density (30-60 nm from the synaptic membrane) positively correlated with DR perform

147 is modified when it is incorporated into the synaptic membrane, possibly by strengthening its interac

148 1) and GluR2/3 subunits of AMPA receptors in synaptic membrane preparations, whereas no change was ob

149 ls, transfected HEK-293 cells, and rat brain synaptic membrane preparations.

150 Hence, the quantity of synaptic membrane probably increased.

151 erations in cochlear mechanics, hair cell or synaptic membrane properties, hair cell innervation, or

152 ntribute to autistic phenotype by modulating synaptic membrane protein expression and neurotransmitte

153 proteins synaptophysin and synaptotagmin; a synaptic membrane protein, plasma membrane-associated pr

154 pose that a presynaptic Ank2-L lattice links synaptic membrane proteins and spectrin to the underlyin

155 Many neuronal and synaptic membrane proteins are known to undergo ES, but

156 The synaptic membrane proteins synaptobrevin, syntaxin, and

157 The synaptic membrane proteins syntaxin, 25K synaptosome-ass

158 We demonstrate here that turnover of synaptic membrane proteins via the endolysosomal pathway

159 ccumulate K63-polyubiquitylated proteins and synaptic membrane proteins, disrupting synaptic vesicle

160 axonal transport cargoes including vesicles, synaptic membrane proteins, mitochondria and prelysosoma

161 lated N-glycosylation sites were enriched in synaptic membrane proteins, such as Ca(2+) ion channels,

162 plays an instructive role in the turnover of synaptic membrane proteins.

163 nt role in the targeting and localization of synaptic membrane proteins.

164 or optimal TCR-induced actin polymerization, synaptic membrane raft polarity, and function in CD8, bu

165 Synaptic membrane-remodeling events such as endocytosis

166 Thus, as with exocytosis, mechanisms of synaptic membrane retrieval may be tuned by the precise

167 neity in the molecular mechanisms underlying synaptic membrane retrieval, even among synapses with si

168 Photoreceptor and synaptic membranes share the highest content of DHA of a

169 In the nervous system, modification of synaptic membrane size has a major impact on synaptic fu

170 poE KO mice to determine the role of apoE in synaptic membrane structure and to determine susceptibil

171 NSF's synaptic membrane substrate, the ternary SNARE complex c

172 calcium channels and as a regulator of post-synaptic membrane targeting for alpha-amino-3-hydroxyl-5

173 now identified a novel alphaGDI complex from synaptic membranes that contains three chaperone compone

174 implicated in regulating NMDAR stability in synaptic membrane, the role of microtubules in regulatin

175 acilitated by the recruitment of PTPalpha to synaptic membranes, the compartment where Fyn resides.

176 But, in synaptic membranes, there was an age-related decrease in

177 in which no electron-lucent microvesicles or synaptic membrane thickenings were visible.

178 Thus, in comparison to GABAA receptors on synaptic membranes, those on CCVs have a reduced alpha 1

179 governed by receptor cycling on and off the synaptic membrane through its interaction with glutamate

180 ate that Rab3 is not in itself essential for synaptic membrane traffic but functions to modulate the

181 ught to play an important regulatory role in synaptic membrane traffic.

182 on of Shrub levels in the FXS model prevents synaptic membrane trafficking defects and strongly resto

183 l dynamic, high-resolution information about synaptic membrane trafficking in intact human brain slic

184 We analyzed whether synaptic membrane trafficking proteins are substrates fo

185 of AMPA receptors are rapidly upregulated in synaptic membranes under conditions associated with pote

186 ttachment of [125I]DTXk bound to channels in synaptic membranes unveiled subunits of Mr = 78 000 and

187 Clathrin and alpha-adaptin relocalization to synaptic membranes upon nerve stimulation.

188 Association of beta8 with synaptic membranes was further supported by its enrichme

189 [(3)H]Fluorowillardiine binding to rat synaptic membranes was increased by D1 by a factor of 3.

190 GLR-1 is localized on synaptic membranes, where it regulates reversals of loco

191 horylated enzyme preferentially localizes to synaptic membranes, whereas phosphorylated GRK5 is found

192 rminals and dendritic spines adjacent to the synaptic membrane, which support a potential role in syn

193 els of GluN2B subunits were decreased in the synaptic membrane, while levels of C2'-containing GluN1

194 e, ephrinB ligands are localized to the post-synaptic membrane, while their cognate Eph receptors are

195 Treatment of synaptic membranes with calpain I resulted in truncation

196 Pre-incubation of synaptic membranes with phosphatase inhibitors significa

197 e accumulation of recycled AChRs in the peri-synaptic membrane without affecting the pre-existing ACh