ライフサイエンスコーパス: synaptic transmission

1 nsmitter receptor mGluR6 in ON-BCs to enable synaptic transmission.

2 r20, increased seizure threshold and altered synaptic transmission.

3 ter segment morphogenesis, ciliogenesis, and synaptic transmission.

4 ns, with fewer synaptic vesicles and altered synaptic transmission.

5 n neural activity, network oscillations, and synaptic transmission.

6 ression, and deficits in cortical excitatory synaptic transmission.

7 vesicle replenishment and sustains reliable synaptic transmission.

8 scuss how such molecular dynamics influences synaptic transmission.

9 e ensembles and contrasting changes in basal synaptic transmission.

10 teins orchestrate their functions to achieve synaptic transmission.

11 resynaptic release to optimize glutamatergic synaptic transmission.

12 t detectably impair excitatory or inhibitory synaptic transmission.

13 ic spine density and rescuing NMDAR-mediated synaptic transmission.

14 up III mGluRs and dysregulated glutamatergic synaptic transmission.

15 egulate important neuronal functions such as synaptic transmission.

16 campal circuits, thereby reducing excitatory synaptic transmission.

17 oughput mapping of neuronal excitability and synaptic transmission.

18 tory homoeostasis, resulting in dysregulated synaptic transmission.

19 thereby shape the efficacy and plasticity of synaptic transmission.

20 action potential dictates the reliability of synaptic transmission.

21 a diagnostic marker and alter NMDAR-related synaptic transmission.

22 ese sex differences with particular focus on synaptic transmission.

23 f ID, ASD and DEE also disrupt glutamatergic synaptic transmission.

24 oid tone mimics GEE effects on cognition and synaptic transmission.

25 rucial for providing the energy required for synaptic transmission.

26 s for increased response to higher frequency synaptic transmission.

27 ndritic arborization, synapse formation, and synaptic transmission.

28 e control likely through enhanced inhibitory synaptic transmission.

29 n regulating GABA(B)R1a function to modulate synaptic transmission.

30 dergic synapses and important for inhibitory synaptic transmission.

31 postsynaptic membrane, ensuring for reliable synaptic transmission.

32 quantal release by exocytosis that underlies synaptic transmission.

33 glutamate release sites to enable efficient synaptic transmission.

34 al substrates that are capable of regulating synaptic transmission.

35 nging from immune and endocrine signaling to synaptic transmission.

36 s of lamina neurons, indicating a failure in synaptic transmission.

37 ion levels of essential proteins involved in synaptic transmission.

38 but it is unclear how these are recoded for synaptic transmission.

39 aptic adaptor protein involved in excitatory synaptic transmission.

40 ted in postsynaptic impairment of inhibitory synaptic transmission.

41 ognized as regulatory elements of excitatory synaptic transmission.

42 ion channels, and key molecules involved in synaptic transmission.

43 Synaptic AMPARs are critical for excitatory synaptic transmission.

44 ters Pin1, preventing its negative action on synaptic transmission.

45 membrane, which support a potential role in synaptic transmission.

46 the synaptic vesicle cycle to ensure normal synaptic transmission.

47 ing neurodevelopment, immune activation, and synaptic transmission.

48 tic spine density, and diminished excitatory synaptic transmission.

49 s on hippocampal glutamatergic and GABAergic synaptic transmission.

50 , but again decreased NMDA-receptor mediated synaptic transmission.

51 nts of synaptic vesicles and the strength of synaptic transmission.

52 refilled rapidly to maintain high-frequency synaptic transmission.

53 A receptors play crucial roles in excitatory synaptic transmission.

54 logical role of cholesterol in glutamatergic synaptic transmission.

55 oward dependence on other Ca(V) channels for synaptic transmission.

56 channel for rapid opening, facilitating fast synaptic transmission.

57 ectrical properties and increased excitatory synaptic transmission.

58 probed the impact of N40D MOR regulation on synaptic transmission.

59 and trafficking, and AMPA receptor-mediated synaptic transmission.

60 on channels [3], molecular motors [4-7], and synaptic transmission [8-11].

61 PSEN1/PSEN2, are implicated in glutamatergic synaptic transmission, a function that is altered by pat

62 vesicles are released during high-frequency synaptic transmission; accordingly, synaptic vesicles ne

63 vesicles are released during high-frequency synaptic transmission; accordingly, synaptic vesicles ne

64 al modeling that estradiol-induced shifts in synaptic transmission alone can increase firing output,

65 R) subunit GluA3 has been suggested to shape synaptic transmission and activity-dependent plasticity

66 tion mimetic cortactin restored the impaired synaptic transmission and ameliorated repetitive behavio

67 e of Amh-mediated postsynaptic modulation of synaptic transmission and Amh-regulated long-term synapt

68 le for astrocyte-neuron interactions in both synaptic transmission and brain ischemia.

69 In vivo, teriflunomide decreased CA3-CA1 synaptic transmission and CA1 mean firing rate and atten

70 Mitochondria provide energy for synaptic transmission and can buffer calcium, impacting

71 sing glutamate, astrocytes actively regulate synaptic transmission and contribute to excitotoxicity i

72 e that associative fear learning potentiates synaptic transmission and cue-specific activity of media

73 16p11.2(dp/+) mice found deficient GABAergic synaptic transmission and elevated neuronal excitability

74 sAPP-GABA(B)R1a binding suppressed synaptic transmission and enhanced short-term facilitati

75 s in sensory neurons relate to inflammatory, synaptic transmission and extracellular matrix reorganiz

76 c and delayed disruption of hippocampal-mPFC synaptic transmission and functional connectivity associ

77 Strikingly, inhibitory synaptic transmission and GABAergic cells were identifie

78 ed that CTZ or light stimulation facilitated synaptic transmission and induced neuroplasticity mimick

79 ivity-dependent, and was independent of fast synaptic transmission and intracellular Ca(2+) levels.

80 receptor potential regulates the strength of synaptic transmission and is shaped by a variety of volt

81 ynapse density and active zones, and altered synaptic transmission and long-term plasticity.

82 application of Abetaos reduced glutamatergic synaptic transmission and long-term potentiation.

83 hat exogenous Amh protein addition increased synaptic transmission and long-term synaptic plasticity

84 pe 1-cannabinoid receptors (CB1) to modulate synaptic transmission and mediate multiple forms of syna

85 ch differentially regulates gene expression, synaptic transmission and memory formation.

86 Both excitatory synaptic transmission and network firing activity increa

87 ck invariably disrupt trophic signaling from synaptic transmission and neuromodulation in addition to

88 At low (nanomolar) levels, it modulates synaptic transmission and neuronal activity, but at much

89 y but also connect homeostatic regulation of synaptic transmission and neuronal excitability.

90 a broader transcriptional program regulating synaptic transmission and neuronal function.

91 However, these changes did not impair synaptic transmission and plasticity and synaptic vesicl

92 Synaptic transmission and plasticity are shaped by the d

93 of PFC DA homeostasis, leading to defective synaptic transmission and plasticity as well as impaired

94 Astrocytes have been shown to modulate synaptic transmission and plasticity in specific cortica

95 escue reduced synapse formation and impaired synaptic transmission and plasticity in stb cKO neurons.

96 that regulate presynaptic calcium channels, synaptic transmission and plasticity in the mammalian CN

97 SD symptoms, and a novel locus implicated in synaptic transmission and plasticity may serve as a poss

98 atory ion channels with fundamental roles in synaptic transmission and plasticity, and their dysfunct

99 sential to control many processes, including synaptic transmission and plasticity, cell growth and di

100 synaptic cargos and impaired maintenance of synaptic transmission and plasticity, contributing to au

101 ciated with psychiatric disorders, including synaptic transmission and plasticity, making it unclear

102 Astrocytes support the energy demands of synaptic transmission and plasticity.

103 dendritic spines is essential for excitatory synaptic transmission and plasticity.

104 r receptors in the brain, where they mediate synaptic transmission and plasticity.

105 t-translational modification is critical for synaptic transmission and plasticity.

106 receptor trafficking, ultimately controlling synaptic transmission and plasticity.

107 which is implicated in regulating excitatory synaptic transmission and plasticity.

108 ior, and demonstrated that intact inhibitory synaptic transmission and proper E/I balance are require

109 erol as an important endogenous regulator of synaptic transmission and provides insight into molecula

110 d 11] results in long-lasting alterations in synaptic transmission and reduced PV expression in the a

111 equired for normal neuronal excitability and synaptic transmission and regulates depression-related b

112 ed the changes in translation and inhibitory synaptic transmission and rescued the synaptic plasticit

113 mportant roles of GluA3 in the maturation of synaptic transmission and short-term plasticity in endbu

114 host spinal cord below the injury to restore synaptic transmission and significantly improve function

115 t of NPAS2 disruption on accumbal excitatory synaptic transmission and strength, along with the behav

116 T alpha2delta proteins (Cacna2d1-4) regulate synaptic transmission and synaptogenesis, but coexpressi

117 anisms by investigating thalamocortical (TC) synaptic transmission and the function of the TC feedfor

118 Endocannabinoids retrogradely regulate synaptic transmission and their abundance is controlled

119 d light-evoked alpha variations may modulate synaptic transmission and visual processing in the retin

120 tivity elicit homeostatic plastic changes in synaptic transmission and/or intrinsic excitability.

121 nnels (pLGICs) are essential determinants of synaptic transmission, and are modulated by specific lip

122 bers, enhances excitatory but not inhibitory synaptic transmission, and augments NMDAR-mediated synap

123 that regulate synaptic function, excitatory synaptic transmission, and dopamine signaling.

124 ultielectrode arrays, increased frequency of synaptic transmission, and elevated calcium transients,

125 lay, pupal death, reduced lifespan, impaired synaptic transmission, and glial and axonal loss.

126 xcitatory synapses, enhanced corticostriatal synaptic transmission, and increased MSN action potentia

127 to stimulate axonal branching, glutamatergic synaptic transmission, and neuronal excitability.

128 log proteins in neurodevelopment, excitatory synaptic transmission, and plasticity.

129 matrix proteins in boosting synaptogenesis, synaptic transmission, and synaptic plasticity.

130 ne if neural activity, network oscillations, synaptic transmission, and/or synaptic plasticity are im

131 Our results indicate that dysregulation of synaptic transmission- and memory function-related genes

132 unctional implications of postsynaptic SR on synaptic transmission are not yet known.

133 velopment and maintenance of corticostriatal synaptic transmission are unclear.

134 Many proteins involved in synaptic transmission are well known, and their features

135 expressed in the brain and is important for synaptic transmission, as neurolastin knockout animals h

136 bunit prevented enhancement of glutamatergic synaptic transmission associated with status epilepticus

137 maps as well as in setting the properties of synaptic transmission at a central auditory nucleus.SIGN

138 GPCR that binds C1ql3, similarly suppressed synaptic transmission at AON->OB projections and abolish

139 d a physiological role of BRI2 in excitatory synaptic transmission at both presynaptic termini and po

140 leus, yet the specific roles of GluA3 in the synaptic transmission at endbulb synapses remains unexpl

141 el cellular mechanism that supports reliable synaptic transmission at high frequency in the CNS.

142 channel activity after injury contributes to synaptic transmission at the first pain synapse however

143 te indicators (GEGIs) allow eavesdropping on synaptic transmission at the level of cleft glutamate to

144 n induced by traumatic stress, and weakening synaptic transmission at these synapses blocks the effec

145 On the other hand, baseline synaptic transmission at this connection, and action pot

146 M(1) mAChRs dynamically modulate synaptic transmission at two PFC inputs whose activity i

147 heteromeric GlyRs (which mediate glycinergic synaptic transmission), because heteromeric GlyRs are le

148 3 disruption in mice leads to dysfunction of synaptic transmission, behavior, and development.

149 These experiments studied synaptic transmission between an Aplysia sensory neuron

150 ssed the contribution of GABA and glycine in synaptic transmission between the medial nucleus of the

151 t endocannabinoid signaling system modulates synaptic transmission between the MHb and its sole ident

152 s in the modulation of synapse formation and synaptic transmission, blood-brain barrier formation, an

153 ctively boosts excitatory synaptogenesis and synaptic transmission by a novel mechanism that is indep

154 tatory but not inhibitory synaptogenesis and synaptic transmission by a novel mechanism that is indep

155 nalysis revealed that UNC-13L's C2A promotes synaptic transmission by regulating a post-priming proce

156 rations, as well as assisting and modulating synaptic transmission by uptake and catabolism of major

157 el-fiber synapses and reduces parallel-fiber synaptic transmission by ~50% without altering release p

158 ecialized functions, including regulation of synaptic transmission, Ca(2+) homeostasis, neuronal exci

159 er, the complex kinetic behavior observed in synaptic transmission cannot be reproduced in a standard

160 enes involved in nervous system development, synaptic transmission, cytoskeleton, gliosis and dopamin

161 in the developing eye causes roughening and synaptic transmission defect, common findings in neurode

162 atory synapses but with increased functional synaptic transmission due to a postsynaptic mechanism, w

163 re is developmental compensation to preserve synaptic transmission during early stages of neuronal ci

164 of GluK2 kainate receptors in L2/3 enhances synaptic transmission during prolonged activity.

165 hat the balance of excitatory and inhibitory synaptic transmission (E/I ratio) is important for prope

166 Synaptic transmission efficacy can be bi-directionally m

167 tosis is essential for maintaining sustained synaptic transmission, especially for neurons that fire

168 The iMSN-D2Rs modulate neuronal activity and synaptic transmission, exerting control on circuit funct

169 s with electrophysiology to characterize the synaptic transmission from a subpopulation of TCs, which

170 gy, and appeared to reduce the efficiency of synaptic transmission from cones to bipolar cells.

171 eptors, negatively modulates corticostriatal synaptic transmission from the first postnatal week onwa

172 Synaptic transmission from these newborn SVZ-derived neu

173 ene clusters: (i) neuronal morphogenesis and synaptic transmission genes in limbic/paralimbic areas;

174 processes that include; muscle contraction, synaptic transmission, hormone secretion and activity-de

175 stration of CTZ enhanced axonal myelination, synaptic transmission, improved thalamocortical connecti

176 tosis through specific mechanisms stabilizes synaptic transmission in a CNS circuit on time scales ra

177 ression could even unravel a defect in basal synaptic transmission in a mouse model of amyloid deposi

178 subset of synapses, and whether it enhances synaptic transmission in addition to boosting synaptogen

179 nit alone is sufficient to rescue inhibitory synaptic transmission in beta1-beta3 triple knockout neu

180 s and the endocannabinoid (eCB) system tunes synaptic transmission in brain regions regulating emotio

181 Excitatory and inhibitory synaptic transmission in CA1 neurons was studied using p

182 that both drugs alter AMPA receptor-mediated synaptic transmission in CA3.

183 ough their agonist isoproterenol potentiated synaptic transmission in cerebellar slices from mice of

184 for the timely dark adaptation and efficient synaptic transmission in cone photoreceptors.

185 the molecular properties of NLGN4 and affect synaptic transmission in human neurons.

186 nsic excitability and spontaneous excitatory synaptic transmission in layer V pyramidal neurons in th

187 facilitate the mechanistic understanding of synaptic transmission in live cells and animals.

188 the impact of A118G on opioid regulation of synaptic transmission in mesolimbic VTA dopaminergic neu

189 with PSD-95 and impaired TARP-mediated AMPAR synaptic transmission in mice hippocampal neurons.

190 ining synaptic differentiation and efficient synaptic transmission in mice, and variants in MACF1 are

191 , and may provide a general means to enhance synaptic transmission in normal and disease states.

192 a history of alcohol drinking did not alter synaptic transmission in PDYN neurons in the CeA of eith

193 ndrial dysfunction affects cell activity and synaptic transmission in psychiatric illnesses is not we

194 ral or synthetic AAS strengthened excitatory synaptic transmission in putative ventral tegmental area

195 ntral nervous system that mediate excitatory synaptic transmission in response to the release of glut

196 derived adenosine has been shown to regulate synaptic transmission in several brain areas, we investi

197 We show that TC synaptic transmission in somatosensory cortex is enhance

198 s of the glutamate receptor subunit GluA3 in synaptic transmission in synapses between auditory nerve

199 ) and excitatory glutamate receptor-mediated synaptic transmission in the CeA, supporting the hypothe

200 nce, PTSD-like behavior responses, GABAergic synaptic transmission in the central amygdala (CeA), and

201 Ca(2+)-permeable component of glutamatergic synaptic transmission in the central nervous system (CNS

202 lies much of our understanding of excitatory synaptic transmission in the central nervous system of a

203 d-gated ion channels that mediate excitatory synaptic transmission in the central nervous system.

204 w, calcium-permeable component of excitatory synaptic transmission in the CNS.

205 ory cortical neurons impairs corticostriatal synaptic transmission in the dorsolateral striatum.

206 synapse formation or the basal parameters of synaptic transmission in the hippocampal Schaffer collat

207 e found that (2R,6R)-HNK enhances excitatory synaptic transmission in the hippocampus through a conce

208 We then performed analyses of synaptic transmission in the LS, stress-induced expressi

209 Fast excitatory synaptic transmission in the mammalian brain is largely

210 it parvalbumin inputs to suppress inhibitory synaptic transmission in the mOFC.

211 covery of long-term depression of inhibitory synaptic transmission in the mouse nucleus accumbens cor

212 ed ion channels that mediate fast excitatory synaptic transmission in the nervous system.

213 s unknown how mu-opioid signaling influences synaptic transmission in the OFC.

214 on, and changes in excitatory and inhibitory synaptic transmission in the PFC.

215 Notably, weakening synaptic transmission in these circuits blocks aggressio

216 Whether synaptic transmission is excitatory or inhibitory depend

217 he electrogenic and biochemical machinery of synaptic transmission is highly sensitive to changes in

218 Synaptic transmission is initiated via spontaneous or ac

219 slices that alpha1-A(R)-mediated excitatory synaptic transmission is mediated by the ionotropic glut

220 Although synaptic transmission is not established until early in

221 The impact of pannexin-1 (Panx1) channels on synaptic transmission is poorly understood.

222 sequences specific to alpha-neurexins enable synaptic transmission is poorly understood.

223 or preventing phosphorylation, revealed that synaptic transmission is similar among the three groups:

224 zolepropionic acid receptor (AMPAR)-mediated synaptic transmission, it is unknown how it exerts this

225 ediates the release of glutamate and impacts synaptic transmission, learning and memory, and neurotox

226 ntral to our understanding the initiation of synaptic transmission, learning, and memory formation.

227 1 and mTORC2, suggesting that mTOR's role in synaptic transmission may be complex-specific.

228 Basal synaptic transmission measured in input-output relations

229 However, transient potentiation of synaptic transmission mediated by activity-dependent rel

230 ecruitment, presynaptic differentiation, and synaptic transmission mediated by neuroligin-1.

231 Membrane fusion during synaptic transmission mediates the trafficking of chemic

232 e in synaptic vesicles and coreleased during synaptic transmission, modulating the postsynaptic ionot

233 vesicles are released during high-frequency synaptic transmission, Na(+) accumulated in terminals an

234 vesicles are released during high-frequency synaptic transmission, Na(+) accumulates in axon termina

235 ficient neurons demonstrate perturbations in synaptic transmission, neuron differentiation, cell prol

236 s completely abolished; however, spontaneous synaptic transmission not only persists but even increas

237 Synaptic transmission occurs when an action potential tr

238 uring neurons in several layers through fast synaptic transmission of acetylcholine (ACh) in rodent m

239 Trans-synaptic transmission of mHtt aggregates is inversely co

240 differentiation, and impaired the excitatory synaptic transmission of NPC-derived neurons.

241 thin postsynaptic density (PSD), and reduced synaptic transmission of pyramidal neurons.

242 d altered inhibitory and enhanced excitatory synaptic transmission of the principal neurons, and redu

243 nc18-1 phosphorylation has a minor impact on synaptic transmission, only after intense activity, and

244 ctivation of these afferent CB1Rs suppresses synaptic transmission onto developing granule cells, and

245 s both excitatory and inhibitory spontaneous synaptic transmission onto GRPR neurons.

246 centration-dependent inhibition of GABAergic synaptic transmission onto medial OFC (mOFC), but not la

247 uce a long-lasting suppression of inhibitory synaptic transmission onto OFC pyramidal neurons in a re

248 tive zones, allowing high rates of sustained synaptic transmission onto the afferent fibres.

249 ocampal slice can propagate without chemical synaptic transmission or gap junctions, but can generate

250 the hippocampus but does not alter baseline synaptic transmission or long-term potentiation.

251 Pyk2 is not required for basal synaptic transmission or LTP, but participates in LTD.

252 n the brain, which is mediated by changes in synaptic transmissions or by changes in ion channel acti

253 tes an EGL-30-Rho pathway, distinct from the synaptic transmission pathway, that increases Wnt produc

254 e identify that these genes are enriched for synaptic transmission pathways and explain significant v

255 enriched for those involved in abnormal CNS synaptic transmission (PFDR = 0.02) and antigen processi

256 red mutations in SNAP25 give rise to related synaptic transmission phenotypes, specific alterations i

257 s a novel role of glial NKCC transporters in synaptic transmission, possibly through regulating extra

258 Here, we investigate the effect of synaptic transmission probabilities on the ability of th

259 A1A-encoded P/Q-type calcium channels impair synaptic transmission, producing early and lifelong neur

260 ese results, we build a model predicting the synaptic transmission properties of a unitary synapse, a

261 Substance P, but not blockade of inhibitory synaptic transmission, reduced opioidergic effects.

262 Chemical synaptic transmission relies on the Ca(2+)-induced fusio

263 f both CAMK2 isoforms abolished LTP, whereas synaptic transmission remained intact.

264 cularly enriched in synapses but its role in synaptic transmission remains poorly understood.

265 However, how APs control the timing of synaptic transmission remains unclear.

266 We also find that synaptic transmission requires the Ncc69 regulatory kina

267 Within the CNS synaptic transmission set, we identify individual signif

268 (+) promoted vesicle recycling and sustained synaptic transmission.SIGNIFICANCE STATEMENT High-freque

269 uscle, which is excited by EGL-30-stimulated synaptic transmission, suggesting a behavioral function

270 omer function in aging adults, including for synaptic transmission, survival, and locomotion.

271 grin1b (-/-)), which lack all NMDAR-mediated synaptic transmission, survive until ~10 d dpf (days pos

272 fold proteins are multi-domain organisers of synaptic transmission that contain three PDZ domains fol

273 e machinery, causing long-lasting changes in synaptic transmission that influence synaptic plasticity

274 Furthermore, spontaneous synaptic transmission that is normally highly Ca(2+)-sen

275 CNS cDNA replicated both the enhancement of synaptic transmission, the reduction of excitability, an

276 frog NMJ is a model synapse for the study of synaptic transmission, there are many unknowns centered

277 /adenosine release, and depresses excitatory synaptic transmission through activation of presynaptic

278 line receptors (nAChRs) mediate and modulate synaptic transmission throughout the brain, and contribu

279 activation of these axons and the resulting synaptic transmission to dorsal horn neurons.

280 uA2-containing AMPARs can sustain sufficient synaptic transmission to evoke low-threshold responses d

281 ated regulation of neuronal excitability and synaptic transmission to influence behavioral output.

282 Here, we assess the role of Doc2 proteins in synaptic transmission under physiological conditions at

283 ts support that M2 and M3 receptors modulate synaptic transmission via different mechanisms.

284 g of how astrocytes can regulate nociceptive synaptic transmission via neuronal-glial and glial-glial

285 Synaptic transmission was impaired in neurons expressing

286 Synaptic transmission was not impacted by the loss of CA

287 change in 'background' calcium that modifies synaptic transmission we compared the facilitation obser

288 To better understand their roles in synaptic transmission, we genetically inactivated mTORC1

289 function, the regulatory effects of MORs on synaptic transmission were recapitulated in two sets of

290 on of synaptic plasticity, and modulation of synaptic transmission were shared between CN and PT.

291 Therefore, during high-frequency synaptic transmission, when large amounts of glutamate a

292 During high-frequency synaptic transmission, when large numbers of synaptic ve

293 wo presynaptic and two postsynaptic steps of synaptic transmission which are modulated by cholesterol

294 tes dopamine-evoked depression of excitatory synaptic transmission, which contributes to amphetamine'

295 uces a long-lasting suppression of GABAergic synaptic transmission, which depends on subregional diff

296 stablish contact with rods to support normal synaptic transmission, which is propagated to the retina

297 h and proliferation, in neurons it regulates synaptic transmission, which is thought to be a major me

298 he tremor was rescued by completely blocking synaptic transmission with tetanus toxin in cerebellar n

299 pport the hypothesis that reduced inhibitory synaptic transmission within the NAc plays a critical ro

300 age induces long-term deficits in inhibitory synaptic transmission within the spinal superficial dors