ライフサイエンスコーパス: synaptically

1 signaling exhibits spatial specificity post-synaptically.

2 gulating neuronal excitability pre- and post-synaptically.

3 se of cells that are quiescent until excited synaptically.

4 e photoreceptor synapses, both pre- and post-synaptically.

5 risomatic-targeting interneurons communicate synaptically.

6 hair (sensillum) can inhibit each other non-synaptically.

7 nd Nav 1.6 were expressed both pre- and post-synaptically.

8 hanges in the hippocampus both pre- and post-synaptically.

9 ined asynchronous firing switched on and off synaptically.

10 In contrast to temporal coding by synaptically acting neurotransmitters such as glutamate,

11 teolytic release of Endostatin signals trans-synaptically, acting in concert with the presynaptic CaV

12 majority of individual AON neurons could be synaptically activated by several mixtures of structural

13 We examined the effects of synaptically activated Ca(2+) waves and NMDA spikes on s

14 in postsynaptic somatic [Ca2+]i produced by synaptically activated glutamate receptors was the resul

15 ux through voltage-gated Ca(2+) channels and synaptically activated NMDA receptors.

16 eromeric GluN1/GluN2A/GluN2B NMDARs and with synaptically activated NMDARs in brain slices from wild-

17 ing tonically activated NMDARs while leaving synaptically activated NMDARs intact.

18 is more potent at inhibiting tonically than synaptically activated NMDARs.

19 Synaptically activated, rapid and dendritic synthesis of

20 Synaptically activating waves in the presence of low con

21 The major synaptically active component inhaled from cigarettes is

22 Our findings suggest that, in synaptically active neurons, modest "basal" levels of po

23 nstrated excitatory GABA signaling, remained synaptically active, and facilitated network activity as

24 improved the proportion of neurons that were synaptically active.

25 tiple types of retinal neurons, resulting in synaptically amplified responses and center-surround ant

26 xposure, and DORs and MORs are synergic both synaptically and behaviorally in producing analgesic eff

27 as more prominent post-synaptically than pre-synaptically and both age and E treatment affected its s

28 and impair many facets of organization trans-synaptically and cell autonomously.

29 ain slices, we examined interactions between synaptically and ER-evoked calcium release at glutamater

30 t with the emerging functional importance of synaptically and extrasynaptically localized DCVs.

31 lpha5 subunits are predominantly found extra-synaptically and seem to interact with radixin for ancho

32 more active zones that transfer information synaptically at higher rates.

33 hree cardinal oscillators: one predominantly synaptically based cortical oscillator and two intrinsic

34 e ON cell population, compared intrinsic and synaptically based receptive fields, and quantified the

35 ), the output cells of the retina, is driven synaptically, because retinal photoreceptors and second-

36 and are thought to bind to each other trans-synaptically, but such interactions have not been demons

37 ted at short latencies, whereas those driven synaptically by AF stimulation (type A cells) were conce

38 Presumed granule cells driven synaptically by LOT stimulation (type L cells) were conc

39 ssuades wiring with the minor input and with synaptically compatible but functionally mismatched affe

40 Another synaptically concentrated laminin receptor, Bcam, is dis

41 , which are shared across even far-flung but synaptically connected brain regions, entrain the ~0.1-H

42 rillary tangles that progressively spread to synaptically connected brain regions.

43 Similarly, synaptically connected cell assemblies or "engrams" are

44 aphtyl acetyl spermine using recordings from synaptically connected cell pairs, NPEC-AMPA uncaging an

45 -10 ms before burst onset, consistent with a synaptically connected chain of neurons in HVC.

46 This study reveals that synaptically connected components of the HIPS, despite r

47 In contrast, other synaptically connected elements of the MTL did not exhib

48 g triple and dual whole-cell recordings from synaptically connected human neocortical layers 2-3 neur

49 ally innervate striatal neurons, and are not synaptically connected in PF.

50 By using paired recordings of synaptically connected interneurons in slice preparation

51 potentiated inhibitory transmission between synaptically connected interneurons.

52 synaptic neurons during paired recordings of synaptically connected layer 4 and layer 2/3 neurons in

53 Using paired recordings from synaptically connected molecular layer interneurons (MLI

54 he origins of sensory transformations across synaptically connected neural populations.

55 fect the behavior of both single neurons and synaptically connected neuronal assemblies.

56 dy investigated whether modifications in the synaptically connected neuronal network of GnRH neurons

57 ay demonstrate a tendency to be expressed by synaptically connected neuronal populations.

58 s show that Cbln2 is frequently expressed by synaptically connected neuronal populations.

59 The specific partnering of synaptically connected neurons is central to nervous sys

60 found that Cbln2 is frequently expressed by synaptically connected neurons, although there are excep

61 AAV1 spreads exclusively or specifically to synaptically connected neurons, and (2) how broad its ap

62 tracellular release and subsequent uptake by synaptically connected neurons, but little is known abou

63 n up, axonally transported, and passed on to synaptically connected neurons.

64 ong the axonal network and propagate between synaptically connected neurons.

65 hat correlated activity drives plasticity in synaptically connected neurons.

66 rvous system in a directional manner between synaptically connected neurons.

67 pread at both the inoculation site and among synaptically connected neurons.

68 ped into a powerful approach for visualizing synaptically connected neurons.

69 trating that PRV transmission is confined to synaptically connected neurons.

70 , finding minimal covariation when comparing synaptically connected or developmentally related cell t

71 rs similarly regardless of whether they were synaptically connected or not.

72 Recordings from synaptically connected pairs of EGFP-TH(+) interneurons

73 In synaptically connected pairs, CCh reduced the short-term

74 atic inhibition change with distance between synaptically connected partners in the rodent hippocampu

75 o explore this possibility, we recorded from synaptically connected PC-CN neuron cell pairs in rats.

76 We re-examined these roles in a model of a synaptically connected population of excitatory neurons

77 dual whole-cell recordings from identified, synaptically connected Renshaw cell-motoneuron pairs in

78 ade simultaneous single-unit recordings from synaptically connected retinal ganglion cells and LGN ne

79 Using dual patch-clamp recording from synaptically connected rod bipolar and AII or A17 amacri

80 creased the amplitude of I(Ca) recorded from synaptically connected rods and caused hyperpolarizing s

81 sponse precision and is widely applicable to synaptically connected spiking neurons.SIGNIFICANCE STAT

82 ted that these catecholaminergic neurons are synaptically connected to BAT.

83 techniques, we confirm that DRA R7 cells are synaptically connected to Dm-DRA1, whereas DRA R8 form s

84 e excitatory MC4R-expressing PVH neurons are synaptically connected to neurons in the parabrachial nu

85 Leptin receptor-positive cells were synaptically connected to respiratory motoneurons.

86 tral spinal progenitors, produced BFCNs that synaptically connected with endogenous neurons, whereas

87 ariety of CNS tissues, where they can become synaptically connected with host circuitry.

88 Because TRCs are not synaptically connected with the afferent nerve fibers, w

89 intermediates in aggregate spreading between synaptically-connected neurons.

90 We also demonstrated that severed axons synaptically contacted NPCs, most of which were VEGF imm

91 These glutamatergic ARC projections synaptically converge with GABAergic ARC(AgRP) projectio

92 opulation of LepRb mPOA neurons) project and synaptically couple to rostral raphe pallidus neurons, c

93 Our analysis suggests that, unlike synaptically coupled assemblies, independent neurons fle

94 ng the virus can move by axonal transport to synaptically coupled brain loci.

95 photoreceptors with voltage steps applied to synaptically coupled HCs and found that feedback is too

96 s evoked by hyperpolarizing steps applied to synaptically coupled HCs.

97 Furthermore, paired recordings between synaptically coupled Ivy and pyramidal cells show that I

98 d to a decrease in synaptic strength between synaptically coupled layer 2/3 cortical pyramidal neuron

99 el expression of any gene of interest in the synaptically coupled neurons, and robustly labels connec

100 performed paired whole-cell recordings from synaptically coupled nRT and TC neurons of the ventrobas

101 l neuron, suggesting that these neurons were synaptically coupled or received common input from the c

102 al neurons, suggesting that these cells were synaptically coupled or received common input from the c

103 e examined these questions by recording from synaptically coupled pairs of cartwheel cells, neurons w

104 We addressed these issues by recording from synaptically coupled pairs of glycine/GABA coreleasing i

105 To investigate this, we made recordings from synaptically coupled pairs of pyramidal neurons in rat v

106 ls had no effect on evoked IPSCs measured in synaptically coupled Purkinje cells.

107 ansiently inhibit action potential firing of synaptically coupled PV cells.

108 Using paired recordings from synaptically coupled RBs and AIIs, we found that a volta

109 uation in distractor processing between mono-synaptically coupled regions of S1 and wMC.

110 s of a deterministic finite-sized network of synaptically coupled spiking neurons and present a forma

111 rons, thereby confirming that pacemakers are synaptically coupled to motor networks in the spinal ven

112 veraging indicated that a subset of C-INs is synaptically coupled to phrenic motoneurons and excitato

113 As of 18 days in vitro (DIV 18), ESNs were synaptically coupled, exhibited spontaneous network acti

114 number of synapses are not likely to remain synaptically coupled.

115 itioned axonal and dendritic branches can be synaptically coupled.

116 cated in SNc, revealing the existence of two synaptically distinct and region-specific subcellular do

117 Light stimulation evoked in all ipRGCs both synaptically driven ('extrinsic') and autonomous melanop

118 ed melanopsin-based ('intrinsic') as well as synaptically driven ('extrinsic') light responses.

119 es of depolarization to LTP induction during synaptically driven action potential firing in hippocamp

120 ations elicited significant increases in the synaptically driven activation of the adjacent, environm

121 When tDCS is of sufficient length, synaptically driven after-effects are induced.

122 , we find that fast tonic firing intensifies synaptically driven burst firing output in dopamine neur

123 of intrinsic and synaptic properties renders synaptically driven firing of interneurons essentially i

124 modulation, including GABAergic inhibition, synaptically driven fluctuations in membrane potential,

125 The spatial extent of the synaptically driven light responses was comparable to th

126 They also exhibit strong synaptically driven light responses.

127 2 cells, M4 cells exhibit robust, sustained, synaptically driven ON responses and dendritic stratific

128 Their synaptically driven photoresponses lack direction select

129 PAR response duration at SC-CA1 synapses and synaptically driven postsynaptic discharge of CA1 pyrami

130 athway and as a relay for rod/cone input via synaptically driven responses.

131 Under low light intensities, where only synaptically driven rod/cone input activates ipRGCs, the

132 ty were physiologically relevant and largely synaptically driven.

133 Here, we show that synaptically-driven reaction-diffusion pathways on dendr

134 rall effect of increased O-GlcNAc is reduced synaptically-driven spike probability via synaptic depre

135 oject to the parabrachial complex (PB), they synaptically engage distinct efferent nodes, the pre-loc

136 tudy evaluates the central circuits that are synaptically engaged by very small subsets of the total

137 rthermore, we provide evidence that SNX27 is synaptically enriched and its level of expression regula

138 Syndapin I (PACSIN 1) is a synaptically enriched membrane tubulating protein that p

139 tivated hypothesis that these organelles are synaptically enriched.

140 tors promoted the generation of long-lasting synaptically evoked "up-states" in matrix SPNs but oppos

141 hamphetamine (METH) or cocaine exposure both synaptically evoked and baclofen-activated GABA(B)R-GIRK

142 l; however, in vivo experiments fail to link synaptically evoked astrocyte Ca(2+) transients and imme

143 Synaptically evoked Ca(2+) influx through N-methyl-D-asp

144 y of CA1 neurons where they are activated by synaptically evoked Ca(2+) influx to limit the size of E

145 In contrast, synaptically evoked Ca(2+) transients are limited to the

146 icient dendritic inhibition leads to greater synaptically evoked calcium transients in the apical den

147 itionally, blocking NO reduces the augmented synaptically evoked dendritic calcium release mediated b

148 the ability of CA1 pyramidal neurons to fire synaptically evoked dendritic spikes and to generate a t

149 Using whole-cell voltage-clamp recording of synaptically evoked EPSCs in adult rat hippocampal slice

150 Finally, the latencies of synaptically evoked global APs and EPSPs were found to c

151 T Our study examines rebound, postburst, and synaptically evoked inhibitory pauses in subpopulations

152 d rebound delays and, importantly, shortened synaptically evoked inhibitory pauses, thereby demonstra

153 found evidence of Kv4.2 internalization upon synaptically evoked LTP in CA1 neurons of hippocampal sl

154 e to females, CbN cells of males had smaller synaptically evoked mGluR1/5-dependent currents, slower

155 rain slices directly showed DHPG-induced and synaptically evoked mitochondrial superoxide production.

156 y their strong effects on both exogenous and synaptically evoked NMDA receptor-mediated currents in m

157 ubtypes, kinetic modeling, and recordings of synaptically evoked NMDAR responses in acute brain slice

158 In addition, synaptically evoked postsynaptic calcium responses were

159 function of Kv3.3 channels in regulating the synaptically evoked Purkinje cell complex spike, the mas

160 annels control the amplitude and duration of synaptically evoked regenerative activity in the distal

161 In addition, dendritically and synaptically evoked responses showed a corresponding dec

162 ebellar stellate cells diffusionally isolate synaptically evoked signals in dendrites and are capable

163 y is observed 48 h after training and alters synaptically evoked spike firing and integrative propert

164 Under physiological conditions, LTP of synaptically evoked spike output was expressed preferent

165 hloride pump can increase the probability of synaptically evoked spiking after photoactivation; this

166 ed in response to optogenetic stimulation or synaptically evoked spiking of NPY+ cells, suppresses bo

167 c spiking, with network state encoded in the synaptically evoked spine Ca(2+) responses.

168 distance information can also be provided by synaptically-evoked BAPs.

169 The CT neurons in S1 synaptically excited S1-projecting thalamocortical (TC)

170 find that the regional distribution of post-synaptically expressed 5-HT receptors better correlates

171 A synaptically generated form of burst firing has been sho

172 requires new transcription, indicating that synaptically generated signals must be transported to th

173 ts intracellular domain in the regulation of synaptically generated signals.

174 We conclude that information derived from synaptically-generated BAPs can indicate synapse locatio

175 ecrete cytokines in one of two modes: either synaptically (i.e., toward antigenic target cells) or mu

176 rons through axon terminals and spread trans-synaptically in a retrograde direction between neurons.

177 dence suggests these channels also exist pre-synaptically in a subset of synaptic terminals within th

178 found that alpha1ARs are found mainly extra-synaptically in axons and axon terminals in the NAc and

179 s required for SIS in vivo, is expressed non-synaptically in several wake-promoting neurons, and like

180 mal fractions revealed that NgR1 is enriched synaptically in the hippocampus.

181 rating the conclusion that GABA does not act synaptically in the mouse LSO.

182 observations that tauopathy can spread trans-synaptically in vivo, via cell-to-cell transfer.

183 ologically suppress RA synthesis, whereas in synaptically inactive neurons, decreases in the resting

184 um ion (Ca(2+)) uptake by mitochondria after synaptically induced Ca(2+)-release from ER and thereby

185 Paradoxically, synaptically induced depolarization will suppress this C

186 m channels and NMDA receptors contributes to synaptically induced LMO4-mediated transactivation.

187 Synaptically induced LTD was deficient in Eif4ebp2(-/-)

188 CA1 of adult rat hippocampus, mechanisms of synaptically induced mGluR-LTD.

189 tase (PTP) is essential for the induction of synaptically induced mGluR-LTD.

190 -phosphorylation, underlies the induction of synaptically induced mGluR-LTD.

191 These cells synaptically integrate into olfactory bulb circuits afte

192 VZ-lineage-tracing mice, SVZ-derived neurons synaptically integrate into the peri-infarct cortex; the

193 ed cortical excitatory neurons that appeared synaptically integrated into the circuitry.

194 received synaptic inputs identifying them as synaptically integrated neurons.

195 onship with motor axons with whom they later synaptically interact.

196 SALM5 promotes synapse development by trans-synaptically interacting with presynaptic LAR-RPTPs and

197 From this work a dispersed but synaptically interconnected network of reinforcement cir

198 d to odor stimulation and how they integrate synaptically into local circuits.

199 tatistics and spike train reproducibility in synaptically isolated cortical neurons were measured in

200 inated LLDs in FTNs, and NMDAR activation in synaptically isolated FTNs induced repetitive LLDs.

201 connect, to define differential patterns of synaptically linked neurons in the taste pathway.

202 d conditional reporter expression in neurons synaptically linked to the Cre-expressing catecholamine

203 urotropic virus that transneuronally infects synaptically-linked chains of neurons in the anterograde

204 bly because of the reduction in the level of synaptically localized AMPA-type glutamate receptors.

205 ated in AD-associated neurodegeneration, and synaptically localized caspase activity could play a rol

206 aMKII is to promote the retrieval-dependent, synaptically localized enhancement of protein synthesis

207 However, the molecular mechanisms regulating synaptically localized ERK1/2 signaling are poorly under

208 ith actin depolymerizing agents disrupts the synaptically localized nectin-1 and afadin cluster at an

209 whose RNAs have been found to interact with synaptically localized proteins.

210 e rate of internalization, leading to larger synaptically localized receptor clusters that increased

211 Activity-dependent transport of synaptically localized transcriptional regulators provid

212 s predicts that glutamine-glutamate cycle is synaptically localized.

213 pposed to bassoon immunoreactivity and hence synaptically localized.

214 Optical recording of synaptically mediated calcium responses identifies LVST-

215 ect photosensitivity through melanopsin with synaptically mediated drive from classical photoreceptor

216 Large, synaptically mediated outward currents were evoked in SG

217 vious studies have shown that norepinephrine synaptically mediates this Prostaglandin E(2) (PGE(2))-d

218 cerbated loss of synaptophysin compared with synaptically more active brain in AD transgenic but not

219 ic cell population to both locally and trans-synaptically offset neurophysiological disruptions produ

220 To determine if and how grafts become synaptically organized and connect with host systems, we

221 Thus synaptically positioned Ca2+-permeable AMPA receptors di

222 Olfactory signals are synaptically processed initially in the olfactory bulb (

223 However, these neurons also synaptically release non-peptide neurotransmitters.

224 We evaluated the contribution of synaptically released acetylcholine (ACh) to executive f

225 al dentate gyrus granule cells, we show that synaptically released acetylcholine preferentially lower

226 GABA(B) receptor dimer (GBB-1/2) that detect synaptically released ACh and GABA, respectively.

227 polarization activates I(h) current in ETCs; synaptically released DA increases I(h), which enhances

228 m by mediating the high-affinity reuptake of synaptically released DA, making it a crucial regulator

229 In brain slices, synaptically released dopamine increases astrocyte Ca(2+

230 rmacological approaches, we demonstrate that synaptically released dopamine inhibits CINs through typ

231 Clearance of synaptically released dopamine is regulated by the plasm

232 the brain, respond with Ca(2+) elevations to synaptically released dopamine, a phenomenon enhanced by

233 trols dopamine neurotransmission by clearing synaptically released dopamine.

234 (COMT) gene, whose protein product degrades synaptically released dopamine.

235 Synaptic GABAA receptors respond to synaptically released GABA and are considered to be unaf

236 Thus, the opposing actions of synaptically released GABA and DA are functionally integ

237 The spillover of synaptically released GABA can also activate extrasynapt

238 Whole-cell recordings further showed that synaptically released GABA in response to extracellular

239 acellular recording to monitor the effect of synaptically released GABA on the DGC population.

240 onsequently, under whole-cell current clamp, synaptically released GABA produced short- and long-last

241 y, I(tonic) may be activated by spillover of synaptically released GABA.

242 of a low-voltage-activated L-type current by synaptically released glutamate accounted nearly fully f

243 sts, suggesting high, but not low, levels of synaptically released glutamate activated mGluRs.

244 Excitatory amino acid transporters remove synaptically released glutamate and maintain its concent

245 rigin that is essential for the clearance of synaptically released glutamate and prevention of excito

246 Perisynaptic AMPARs do not normally detect synaptically released glutamate but can do so when the g

247 kedly prolongs the extracellular lifetime of synaptically released glutamate by reducing GLT-1 surfac

248 fore the second postnatal week, clearance of synaptically released glutamate depends primarily on dif

249 es longer than the extracellular lifetime of synaptically released glutamate estimated with uptake me

250 lectrophysiological approaches, we find that synaptically released glutamate fails to trigger GABA re

251 Efficient clearance of synaptically released glutamate from the extracellular s

252 ters terminate neurotransmission by clearing synaptically released glutamate from the extracellular s

253 Furthermore, synaptically released glutamate induced by electrical st

254 ng neuronal NMDA receptors with exogenous or synaptically released glutamate led to Miro1 positioning

255 To further determine whether synaptically released glutamate mediates VGluT1(+) synap

256 was able to manipulate negative feedback of synaptically released glutamate on transmitter release.

257 As D-serine is localized in glia, synaptically released glutamate presumably stimulates th

258 synaptic structure to regulate the time that synaptically released glutamate remains in the extracell

259 mate reuptake and attenuates the increase in synaptically released glutamate that accompanies cocaine

260 Glutamate transporters clear synaptically released glutamate to maintain precise comm

261 iGluSnFR competes with transporters to bind synaptically released glutamate, delaying glutamate upta

262 er supplies the precursor for generating the synaptically released glutamate, we measured miniature E

263 n increases, potentially speeding removal of synaptically released glutamate, whereas extracellular s

264 to neurons and glia terminate the actions of synaptically released glutamate.

265 to mature, processes that are influenced by synaptically released glutamate.

266 Synaptically released glycine also enhanced tonic glycin

267 tane-1,5-dioic acid, would elevate levels of synaptically released NAAG and reduce PCP-induced increa

268 activation of G protein-coupled receptors by synaptically released neurotransmitters demonstrated not

269 hrine transporter (NET) mediates reuptake of synaptically released norepinephrine in central and peri

270 a membrane protein that mediates reuptake of synaptically released norepinephrine.

271 nigrostriatal projections that may modulate synaptically released striatal glutamate.

272 deficient in zinc transporters to show that synaptically released zinc inhibits postsynaptic kainate

273 extrasynaptic NMDARs that are not reached by synaptically released zinc, but which are inhibited by a

274 e brain areas may impair normal clearance of synaptically-released glutamate and contribute to neural

275 which is associated with faster clearance of synaptically-released glutamate from the extracellular s

276 This capacity to signal across such a large synaptically relevant bandwidth enhances the response to

277 del of glaucoma, C1q becomes upregulated and synaptically relocalized in the adult retina early in th

278 This paradigm predicts that synaptically secreted cytokines such as IFN-gamma will p

279 usion, defining a period where excitable but synaptically silent neurons are present.

280 n of active arbors and local degeneration of synaptically silent ones.

281 ructural synapses, which however remain post-synaptically silent, suggesting that completion of early

282 urons in the upper layers of pOFC, which are synaptically suited to suppress noise and enhance signal

283 Teevra cells synaptically target GABAergic axo-axonic and some CCK in

284 ch does not bind PSD-95 PDZ domains, is less synaptically targeted and promotes dendritic arborizatio

285 In vivo imaging of transmission using synaptically targeted GCaMP3 to detect Ca(2+) influx thr

286 reduce post-synaptic assembly, whereas post-synaptically targeted RNAi has no effect, indicating tha

287 ERbeta-ir was more prominent post-synaptically than pre-synaptically and both age and E tr

288 Synaptically, the wake-promoting neurons were organized

289 rated that EES engages spinal circuits trans-synaptically through the recruitment of myelinated affer

290 ke in the adult, where this transmitter acts synaptically to inhibit neurons, during development, GAB

291 n-expressing interneurons that are connected synaptically to the Grp+ neurons.

292 Prey-derived chemosensory signals are synaptically transmitted to acutely relieve nCa(V) inact

293 otoreceptors, processed by interneurons, and synaptically transmitted to retinal ganglion cells (RGCs

294 feature a special processing mode, namely, a synaptically triggered action potential that is restrict

295 Olfactory bulb granule cells are activated synaptically via two main pathways.

296 lpha2, or alpha3 subunits are mainly located synaptically where they interact with the submembranous

297 er between neurons transneuronally and trans-synaptically, which is thought to explain the progressiv

298 aptic adhesion molecules that interact trans-synaptically with multitudinous postsynaptic adhesion mo

299 cell adhesion molecules that interact trans-synaptically with neurexins to mediate synapse developme

300 ic neuroligins are thought to interact trans-synaptically with presynaptic neurexins.