ライフサイエンスコーパス: syncytiotrophoblast

1 creted by trophoblastic cells, mostly by the syncytiotrophoblast.

2 r differentiation into both extravillous and syncytiotrophoblast.

3 a, that is a unique compartment known as the syncytiotrophoblast.

4 hoblast and coordinately lost in postmitotic syncytiotrophoblast.

5 iformly bind to chondroitin sulfate A on the syncytiotrophoblast.

6 ial cells that may be analogous to the human syncytiotrophoblast.

7 ociated with the microvilli of the placental syncytiotrophoblast.

8 to the pH-neutral basolateral surface of the syncytiotrophoblast.

9 ast cells fuse to produce the multinucleated syncytiotrophoblast.

10 ophoblasts and the microbial-resistant cell, syncytiotrophoblast.

11 ding the transcriptome of the multinucleated syncytiotrophoblast.

12 essed in the basal membrane of the placental syncytiotrophoblast.

13 rentiation program: fusion into an overlying syncytiotrophoblast.

14 phoblasts compared to that in differentiated syncytiotrophoblast.

15 MMP-14 was predominately localized to the syncytiotrophoblast.

16 several placental cell types, including the syncytiotrophoblast.

17 esence of both ET-1 and its receptors in the syncytiotrophoblast.

18 space and also at significant levels to the syncytiotrophoblasts.

19 ffecting differentiation of the labyrinthine syncytiotrophoblasts.

20 ramatically as cytotrophoblasts fuse to form syncytiotrophoblasts.

21 tissue, and at very high levels by placental syncytiotrophoblasts.

22 genesis, is required for cell-cell fusion of syncytiotrophoblasts.

23 trimester placenta, specifically in EVTs and syncytiotrophoblasts.

24 otrophoblast progenitors into multinucleated syncytiotrophoblasts.

25 o the mother and shunts uterine blood to the syncytiotrophoblasts.

26 tiate to either extravillous trophoblasts or syncytiotrophoblasts.

27 n/nodal inhibition leads to the formation of syncytiotrophoblasts.

28 mediates adherence to CSA on the surface of syncytiotrophoblasts.

29 pment and is expressed, like CS and GH-V, in syncytiotrophoblasts.

30 The syncytiotrophoblast, a cell of fetal origin, is known to

31 oviral fusogens known as syncytins forms the syncytiotrophoblast, a multinucleated cell structure ess

32 galectins are predominantly expressed by the syncytiotrophoblast, a primary site of metabolic exchang

33 the hypothesis that release occurs from the syncytiotrophoblast after the induction of apoptotic cha

34 onstrated that TRAIL protein is prominent in syncytiotrophoblast, an uninterrupted placental cell lay

35 They are secreted by the syncytiotrophoblast and are detected around day 14 postf

36 EPI64 colocalizes with EBP50 and ezrin in syncytiotrophoblast and cultured cell microvilli, and th

37 ey spontaneously fuse to form a multinuclear syncytiotrophoblast and CYP19 expression is markedly ind

38 , we demonstrate for the first time that the syncytiotrophoblast and cytotrophoblast are a major site

39 vestigate the possibility that the placental syncytiotrophoblast and deported trophoblastic debris se

40 rst and second-trimester placenta as well as syncytiotrophoblast and extravillous cytotrophoblast of

41 ucted lineage trajectories to multinucleated syncytiotrophoblast and extravillous trophoblast populat

42 ytotrophoblast cells but not in post-mitotic syncytiotrophoblast and invasive extravillous cytotropho

43 Ebolavirus antigen was seen in the syncytiotrophoblast and placental maternal mononuclear c

44 ycerate mutase (BPGM) was upregulated in the syncytiotrophoblast and spiral artery trophoblast cells

45 g pregnancy soluble CORIN is released by the syncytiotrophoblast and that increased levels of soluble

46 during cytotrophoblast differentiation into syncytiotrophoblast and the impact of any changes on PlG

47 MT1-MMP was expressed predominantly in the syncytiotrophoblast and the villous and extravillous cyt

48 bs show extensive expression of hFcRn in the syncytiotrophoblast and traces in the endothelium and ot

49 to investigate the presence of mHAgs in the syncytiotrophoblast and trophoblast debris shed from fir

50 duce mesoderm progeny, APA(+) cells generate syncytiotrophoblasts and CD87(+) cells give rise to vasc

51 articipate in immune responses, formation of syncytiotrophoblasts and cell-fate specification.

52 s)-precursors of the mature placental cells, syncytiotrophoblasts and cytotrophoblasts, in chorionic

53 (FcR) binding affinity, and FcR abundance in syncytiotrophoblasts and endothelial cells contribute to

54 ages and further specify into multinucleated syncytiotrophoblasts and extravillous trophoblast cells.

55 ndistinguishable results were obtained using syncytiotrophoblasts and in experiments using trophoblas

56 and in situ in 18- to 20-week-old placental syncytiotrophoblasts and invasive trophoblasts.

57 expressed in progenitor cytotrophoblasts and syncytiotrophoblasts and is overexpressed in preeclampsi

58 o the formation of multinucleated myofibers, syncytiotrophoblasts and osteoclasts, allowing their res

59 We validated this fusion of syncytiotrophoblasts and stromal cells using human blast

60 This enabled isolation of syncytiotrophoblasts and two subpopulations of invasive

61 nclude cytotrophoblasts differentiating into syncytiotrophoblasts) and anchoring villi (which include

62 ignal sequence receptor 1) were found in the syncytiotrophoblast, and one antigen (DDX3Y) was found i

63 ned to the late endosomal compartment of the syncytiotrophoblast, and tightly associated to the gener

64 G glycoprotein also was expressed in villous syncytiotrophoblasts, and accumulation of Mamu-AG glycop

65 rescence staining of the endogenous RBCs and syncytiotrophoblasts, and co-localization of CSPG and IR

66 Formations of myofibers, osteoclasts, syncytiotrophoblasts, and fertilized zygotes share a com

67 lasts, 128 with cytotrophoblasts and 80 with syncytiotrophoblasts, and included genes such as FLT1, G

68 fferentiated into chorionic trophoblasts and syncytiotrophoblasts, as demonstrated by their expressio

69 onitis and increased TNF-alpha production by syncytiotrophoblasts assessed by immunohistochemistry (a

70 domains where trophoblast cells fuse into a syncytiotrophoblast at the fetomaternal interface, consi

71 Placental syncytiotrophoblasts at the maternal-fetal interface rel

72 insights into the defense mechanisms used by syncytiotrophoblasts at various stages of human gestatio

73 For example, HVEM was identified on syncytiotrophoblast but not in villous mesenchymal cells

74 PL is normally only expressed in placental syncytiotrophoblasts, but PL genes are amplified and exp

75 In the human placental syncytiotrophoblast, C(19) steroids are converted to est

76 pathology that involves severe disruption to syncytiotrophoblast cell differentiation.

77 ified decreased Fpn1 expression in placental syncytiotrophoblast cells at late gestation as the mecha

78 RESULTSSARS-CoV-2 localized predominantly to syncytiotrophoblast cells at the materno-fetal interface

79 In vitro studies using primary syncytiotrophoblast cells demonstrated that LIGHT direct

80 The protein was highly expressed in the syncytiotrophoblast cells of the labyrinth layer of the

81 lls, and in the case of pregnancy, placental syncytiotrophoblast cells) and several forms of chaperon

82 developed 3D cell-line-based models of human syncytiotrophoblasts, cells that lie in direct contact w

83 The antigens were detected in the placental syncytiotrophoblasts, chorionic trophoblasts, decidual c

84 the presence of distinct cytotrophoblast and syncytiotrophoblast clusters and a small cluster of extr

85 he maternal vessels and endometrium, whereas syncytiotrophoblasts covering trophoblastic lacunae or n

86 ctoderm with subsequent differentiation into syncytiotrophoblast, cytotrophoblast, and downstream tro

87 tal trophoblast to ZIKV: cytotrophoblast and syncytiotrophoblast derived from placental villi at term

88 may be due to excessive release of placental syncytiotrophoblast-derived extracellular vesicles (STBE

89 PR knockout in an in vitro cellular model of syncytiotrophoblast development (BeWo cells), we found t

90 dosage impacts a widely used model for human syncytiotrophoblast development.

91 In chorionic villi, syncytiotrophoblasts did not become infected, although c

92 Overexpression of Mash-2 prevents syncytiotrophoblast differentiation and induction of CYP

93 en cytotrophoblasts are cultured in 2% O(2), syncytiotrophoblast differentiation and induction of CYP

94 teasomal degradation of USF1/2, resulting in syncytiotrophoblast differentiation and induction of hCY

95 USF2 and DNA-binding activity declined with syncytiotrophoblast differentiation and were maintained

96 otein binding to these E boxes declined with syncytiotrophoblast differentiation in 20% O(2) and was

97 ough TFEB appears to play a critical role in syncytiotrophoblast differentiation, ablation of TFEB la

98 ich are indicative of spongiotrophoblast and syncytiotrophoblast differentiation, respectively.

99 to define mechanisms for O(2) regulation of syncytiotrophoblast differentiation, we found that hypox

100 at elevated levels by hypoxia, declines with syncytiotrophoblast differentiation.

101 depletion imply that MSX2 prevents premature syncytiotrophoblast differentiation.

102 cytotrophoblasts dramatically decreased upon syncytiotrophoblast differentiation.

103 ression of these microRNAs (miRNAs) impaired syncytiotrophoblast differentiation.

104 5, that are significantly downregulated upon syncytiotrophoblast differentiation.

105 binding activity to the Gcm1 promoter during syncytiotrophoblast differentiation.

106 Upon removal, syncytiotrophoblasts disintegrate and invasive cytotroph

107 roitin sulfate A (CSA) on the surface of the syncytiotrophoblast during placental malaria.

108 for the fusion of cytotrophoblast cells into syncytiotrophoblasts during placental development.

109 Likewise, primary human syncytiotrophoblast exposed to hemozoin, tumor necrosis

110 ng the surface of villi that float in blood, syncytiotrophoblasts express the neonatal Fc receptor (F

111 In placental villi, syncytiotrophoblasts express the virion receptor epiderm

112 Syncytiotrophoblast extracellular microvesicles (STEVs)

113 PE), there is increased release of placental syncytiotrophoblast extracellular vesicles (STBEVs) and

114 ed a consistent pattern of MIF expression in syncytiotrophoblasts, extravillous trophoblasts, IVB mon

115 f MT1-MMP and MT2-MMP, which is critical for syncytiotrophoblast formation and in turn for fetal vess

116 cm1) in trophoblast cells, preventing excess syncytiotrophoblast formation and permitting normal plac

117 in the process of cell fusion necessary for syncytiotrophoblast formation and that during this physi

118 equired for increased expression of Gcm1 and syncytiotrophoblast formation as well as impaired placen

119 n-B (SynB), a mouse syncytin responsible for syncytiotrophoblast formation at the fetomaternal interf

120 this interaction regulates Gcm1 expression, syncytiotrophoblast formation, placental vascularization

121 retroviral origin, is crucial for placental syncytiotrophoblast formation.

122 whereas lack of Plet1 preferentially induces syncytiotrophoblast formation.

123 In contrast, syncytiotrophoblasts from placentas with high neutralizi

124 Functionally, the derepression of many syncytiotrophoblast genes after MSX2 knockdown is likely

125 reconstituted apical membranes of term human syncytiotrophoblast (hST), containing endogenous PC2 (PC

126 enerates all labyrinth trophoblast subtypes, syncytiotrophoblasts I and II, and sinusoidal trophoblas

127 layers of the mouse placental labyrinth, the Syncytiotrophoblast-I lineage, initially share similar t

128 ells in first trimester placentas and to the syncytiotrophoblast in term placentas.

129 acenta, HO-2 immunostaining was prominent in syncytiotrophoblast in the first trimester and reduced t

130 reduced fusion of cytotrophoblast cells into syncytiotrophoblast in vivo, (2) increased SUPYN transcr

131 placenta, able to differentiate either into syncytiotrophoblasts in floating chorionic villi or extr

132 totrophoblasts in the first trimester and to syncytiotrophoblasts in the third trimester.

133 al cytotrophoblasts were differentiated into syncytiotrophoblasts in vitro to examine AP-2 expression

134 nscytosed by the neonatal Fc receptor across syncytiotrophoblasts, infect underlying cytotrophoblasts

135 kness, and the apical plasma membrane of the syncytiotrophoblast interacts directly with maternal blo

136 villous cytotrophoblasts with the overlying syncytiotrophoblast is essential for the maintenance of

137 ese results suggest that oxidative stress in syncytiotrophoblast is promoted by both hemozoin exposur

138 Syncytiotrophoblast is the multinucleated epithelium of

139 Syncytiotrophoblast is the primary barrier regulating th

140 d2 in sinusoidal trophoblast giant cells and syncytiotrophoblasts is likely to have a non-cell autono

141 IgG transport across the first layer, the syncytiotrophoblast, is almost certainly mediated by the

142 ion chorionic villous explants, we show that syncytiotrophoblasts isolated from the second trimester

143 reveal defects in the maternal blood-facing syncytiotrophoblast layer as a shared pathology in place

144 acentae exhibited reduced BPGM levels in the syncytiotrophoblast layer compared to placentae from hea

145 ZO1 deficiency disrupts the formation of the syncytiotrophoblast layer in the placenta.

146 cells, including villous macrophages and the syncytiotrophoblast layer of placenta, Kupper cells in t

147 al zone, where trophoblast cells fuse into a syncytiotrophoblast layer to form the maternofetal inter

148 these genes were primarily localised to the syncytiotrophoblast layer, and showed decreased expressi

149 cells at the level of the cognate placental syncytiotrophoblast layer.

150 nce the fetomaternal interface comprises two syncytiotrophoblast layers (ST-I and ST-II) instead of o

151 cental defects in the spongiotrophoblast and syncytiotrophoblast layers, resulting in an arrest of va

152 terminal differentiation and polarization of syncytiotrophoblasts, leading to intrauterine fetal grow

153 ate cytotrophoblast cells (18 h culture) and syncytiotrophoblast-like cells (66 h culture).

154 dings established MSX2 as a repressor of the syncytiotrophoblast lineage and demonstrated its pivotal

155 entiated to the extravillous trophoblast and syncytiotrophoblast lineages and exhibited high transcri

156 lycan chondroitin sulfate A (CSA) present on syncytiotrophoblasts lining the placental blood spaces.

157 sis that excess Galphaq signaling within the syncytiotrophoblast may contribute.

158 activity, could have major implications for syncytiotrophoblast metabolism and function as well as f

159 lucose transporter isoform 1 (GLUT-1) on the syncytiotrophoblast microvillous and basal plasma membra

160 ral amino acid transporter (LAT) isoforms in syncytiotrophoblast microvillous membranes (MVMs).

161 Placentas were homogenized, and syncytiotrophoblast microvillous plasma membrane (MVM) a

162 r sites of syncytin expression are placental syncytiotrophoblasts, multinucleated cells that originat

163 Western blotting, and immunolocalized to the syncytiotrophoblast; necrosis was also evidenced by rele

164 Whereas eNOS was expressed by syncytiotrophoblast, neither eNOS or iNOS was expressed

165 in non-excitable tissue, is apparent in the syncytiotrophoblast of both first trimester and term hum

166 TRPC6 staining was present in the syncytiotrophoblast of both first trimester and term pla

167 Whereas B7-DC was prominent on the syncytiotrophoblast of early placenta, it was absent fro

168 Furthermore, ET-1 levels increased in the syncytiotrophoblast of explants from normal placentas af

169 ophoblast, cytotrophoblast cell columns, and syncytiotrophoblast of first and second-trimester placen

170 [Ca2+]i in syncytiotrophoblast of first trimester and term placenta

171 we show that aquaporin-4 is expressed in the syncytiotrophoblast of human and mouse placenta.

172 okine fractalkine, which is expressed in the syncytiotrophoblast of human placenta, from where it is

173 ere significantly reduced in brush border of syncytiotrophoblast of infected placentas; (b) amounts o

174 l staining for HLA-Class II was increased in syncytiotrophoblast of placentas with CHI (Grade 0.44 [I

175 channel that controls PC2 function in human syncytiotrophoblast of term placenta.

176 e an important route for Ca2+ entry into the syncytiotrophoblast of term, but not first trimester pla

177 expression of NKB was confined to the outer syncytiotrophoblast of the placenta, significant concent

178 er of tissues, including ovary, adipose, and syncytiotrophoblast of the placenta.

179 lope genes were found to be expressed in the syncytiotrophoblasts of human and mouse placenta and to

180 immunoreactive protein(s) was present in the syncytiotrophoblasts of the chorionic villi of the rhesu

181 xcept for keratinocytes of the hair bulb and syncytiotrophoblasts of the placenta, but was present in

182 1 confirmed high expression in the cyto- and syncytiotrophoblasts of the placenta.

183 to the mature cell types of chorionic villi-syncytiotrophoblasts on the surfaces of floating villi a

184 on as well as improving knowledge of how the syncytiotrophoblast operates.

185 a further differentiation towards cells with syncytiotrophoblast or extravillous trophoblast features

186 ent by promoting differentiation towards the syncytiotrophoblast or giant cell pathway in Plet1-low a

187 ro E6, the virus inside cytotrophoblasts and syncytiotrophoblasts or in the supernatant 4 days after

188 We recently demonstrated that PC2 from human syncytiotrophoblast (PC2hst) but not the in vitro transl

189 m a preparation of apical membranes of human syncytiotrophoblast (PC2hst) reconstituted in a lipid bi

190 Decreased syncytiotrophoblast POA synthesis may contribute to insu

191 The placental syncytiotrophoblast releases micro and nanovesicles (STB

192 (CT) ends in formation of the multinucleated syncytiotrophoblast representing the fetal-maternal inte

193 The characteristics and key drivers of the syncytiotrophoblast response to oxidative stress were in

194 Syncytiotrophoblast-restricted Galphaq activation caused

195 ore, we also identify that loss of Cited2 in syncytiotrophoblasts results in the subcellular mislocal

196 and antioxidant responses within villous and syncytiotrophoblast samples of human preeclamptic placen

197 be cultured long term and differentiated to syncytiotrophoblast (SCT) and extravillous trophoblast (

198 The syncytiotrophoblast (SCT) at the maternal-fetal interfac

199 racterized cell lineages, differentiation of syncytiotrophoblast (SCT), a cell type critical for horm

200 to either extravillous trophoblast (EVT) or syncytiotrophoblast (SCT).

201 oblast cell types [cytotrophoblast (CTB) and syncytiotrophoblast (SCT)] in pregnant persons with gest

202 The placental syncytiotrophoblasts (SCTB) express high levels of iron

203 rical organoids with a single outer layer of syncytiotrophoblast (ST) cells that display a barrier fu

204 onuclear colonies, whereas upon induction of syncytiotrophoblast (ST) differentiation multinuclear st

205 n of trophoblast cells into a multinucleated syncytiotrophoblast (ST) layer.

206 differentiation of cytotrophoblast (CT) into syncytiotrophoblast (ST).

207 t can be differentiated into early gestation syncytiotrophoblasts (ST) and extravillous trophoblasts

208 nctional extravillous trophoblasts (EVT) and syncytiotrophoblasts (ST).

209 ents of a placental villous functional unit, syncytiotrophoblast (STB) and villous core.

210 (EVT) cells and instead show a bias towards syncytiotrophoblast (STB) differentiation, thus indicati

211 TB), precursors to terminally differentiated syncytiotrophoblast (STB) in chorionic villi and extravi

212 The syncytiotrophoblast (STB) is a multinucleated cell layer

213 Continuous formation of the multinucleated syncytiotrophoblast (STB) layer via differentiation and

214 B) progenitor-like cells, and then into both syncytiotrophoblast (STB)- and extravillous trophoblast

215 , but inhibits cell fusion and production of syncytiotrophoblast (STB)-specific proteins, such as hCG

216 genes were known to be uniquely expressed in syncytiotrophoblast (STB)-subtype of placental cells and

217 ility to fuse and differentiate, forming the syncytiotrophoblast (STB).

218 ophoblast (EVT) lineage or the multinucleate syncytiotrophoblast (STB).

219 tion into extravillous trophoblast (EVT) and syncytiotrophoblast (STB).

220 phoblast, extravillous trophoblast (EVT) and syncytiotrophoblast (STB).

221 nd its differentiation toward multinucleated syncytiotrophoblasts (STBs) and invasive extravillous tr

222 iated into extravillous trophoblasts (EVTs), syncytiotrophoblasts (STBs), and organoids, and this stu

223 s are responsible for gas/nutrient exchange (syncytiotrophoblasts, STBs) and invasion and maternal va

224 We use human cytotrophoblast and syncytiotrophoblast stem cell cultures, polarized tropho

225 ta demonstrate a causal relationship between syncytiotrophoblast stress and the development of preecl

226 Syncytiotrophoblast stress is theorized to drive develop

227 iation of trophoblast stem cells (TSCs) into syncytiotrophoblasts (STs) and extravillous trophoblasts

228 ominant ATOH8 expression in EVTs compared to syncytiotrophoblasts (STs) and TSCs.

229 differentiates into cytotrophoblasts (CTs), syncytiotrophoblasts (STs), and extravillous trophoblast

230 EL, Annexin V binding and ADP:ATP in CTs and syncytiotrophoblasts (STs).

231 e that all three isoforms are present in the syncytiotrophoblast suggesting each plays a role in amin

232 1 is found at the basal surface of placental syncytiotrophoblasts, suggesting that it also transports

233 xpressed in the apical membrane of placental syncytiotrophoblasts, suggesting that it may protect the

234 nt both in the intervillous space and on the syncytiotrophoblast surface, HA is absent in these locat

235 and secondly, maternal blood surrounding the syncytiotrophoblast (SYN).

236 (CytT), before and after differentiation to syncytiotrophoblast (SynT) in primary culture, revealed

237 endocytic processes, and is expressed in the syncytiotrophoblast (SynT), an epithelial layer at mater

238 relies on the development of multinucleated syncytiotrophoblasts (SynT) from trophoblast progenitors

239 last (CTB) progenitors differentiate to form syncytiotrophoblasts (SynTBs), which provide the exchang

240 Maternal obesity results in decreased syncytiotrophoblast synthesis of palmitoleic acid, a fat

241 l placenta, maternal blood directly contacts syncytiotrophoblasts that cover chorionic villi and cyto

242 he microvillous plasma membrane (MVM) of the syncytiotrophoblast, the transporting epithelium of huma

243 First, the syncytiotrophoblast, the transporting epithelium of the

244 dent on delivery of fatty acids (FAs) by the syncytiotrophoblast, the transporting epithelium of the

245 ture and villous cytotrophoblasts underlying syncytiotrophoblasts, then reaches blood vessels in the

246 Bs in the villous chorion differentiate into syncytiotrophoblasts, they take an alternative trajector

247 ever, LEPTIN gene expression was diminished, syncytiotrophoblast TNFalpha immunostaining elevated and

248 oss the basal membrane (BM) of the placental syncytiotrophoblast to the fetus, although vital for ami

249 letion of MSX2 resulted in activation of the syncytiotrophoblast transcriptional program, while force

250 erine vasculature, or fuse into multinuclear syncytiotrophoblasts transporting oxygen and nutrients t

251 suggesting a role for this pathway in murine syncytiotrophoblast turnover.

252 d maternal immunoglobulin G were detected in syncytiotrophoblasts, villus core macrophages, and dendr

253 Primary syncytiotrophoblast was exposed to hemozoin and tumor ne

254 cental IL-1beta, and TNF-alpha production by syncytiotrophoblasts was independently associated with d

255 In vitro studies demonstrated that syncytiotrophoblasts were not a major source of sTNFR.

256 villi that were infected with CMV in utero, syncytiotrophoblasts were often spared, whereas cytotrop

257 underlying villus cytotrophoblasts, whereas syncytiotrophoblasts were spared.

258 lacenta in the apical plasma membrane of the syncytiotrophoblasts, where the transferrin-bound iron i

259 by conversion to trophoblast, and especially syncytiotrophoblast, whereas an A83-01/PD173074 combinat

260 se, and differentiate to form multinucleated syncytiotrophoblast with induction of aromatase (hCYP19A

261 (2), human cytotrophoblasts fuse to form the syncytiotrophoblast with marked induction of hCYP19 (aro

262 of CMV transmission to the fetus: (i) across syncytiotrophoblasts with subsequent infection of the un

263 was found in both human and mouse placentae syncytiotrophoblast, with higher expression facing the m

264 CSF-1R and CSF-1 in the cytotrophoblast and syncytiotrophoblast within ectopic implantation sites fr

265 These cells, particularly areas of syncytiotrophoblast within the colonies, quickly become