ライフサイエンスコーパス: synergism

1 ith the lowest intakes, suggesting potential synergism.

2 mensal may be utilized to attenuate pathogen synergism.

3 ithromycin resistance and subsequent loss of synergism.

4 Bliss independence model were used to assess synergism.

5 y, along with the mechanisms involved in the synergism.

6 quired MRSA USA300 strain, indicating strong synergism.

7 recombinant lFBPase exhibits AMP/Fru-2,6-P2 synergism.

8 g degrees of nonlinear blending and additive synergism.

9 with at least another compound, suggesting a synergism.

10 thma due to interaction was 7.2%, indicating synergism.

11 nses and provide insights into monocot viral synergism.

12 dy PMV- and SPMV-host interactions and viral synergism.

13 signaling pathways that modulate leptin/CCK synergism.

14 ted feedback loops display the mechanisms of synergism.

15 the effect of these molecules on leptin/CCK synergism.

16 xpression of one of the GRs involved in this synergism.

17 molecular mechanisms of gene-by-environment synergism.

18 both motifs appear important for functional synergism.

19 are for fast and accurate prediction of drug synergism.

20 etter electronic properties with an improved synergism.

21 due to possible agglomeration and decreased synergism.

22 the activation and reduced or eliminated the synergism.

23 rostatic pressure significantly enhanced the synergism.

24 hown great advantages due to their catalytic synergism.

25 ctions indeed played a role for the observed synergism.

26 ory systems can operate cooperatively and in synergism.

27 bacterial membranes and exhibit an exemplary synergism.

28 comutated driver genes suggesting functional synergism.

29 at their combination (up to ~46%) indicating synergisms.

30 apy approach displays significant anticancer synergism, abrogates this epigenetic-mediated, multi-pro

31 y Taxol treatment was found to show the best synergism among all combination strategies.

32 This leads to the conclusion that synergism among cellulases is morphology-dependent and g

33 GFRalpha-driven glioma through combinatorial synergism and increased tumor accumulation of dasatinib.

34 apacity for different cancer treatments with synergism and multidrug resistance inhibition, which has

35 ous materials with unprecedented tunability, synergism and precision.

36 We quantified this synergism and ranked these hotspots using a difference i

37 nature of site 2 account for the DksA-ppGpp synergism and suggest mechanisms for ppGpp enhancement o

38 hlight the importance of validating in vitro synergism and the challenge of matching drug exposures t

39 s the pivotal determinant of the OX(1)-CB(1) synergism and thus suggest a functional rather than a mo

40 rithms for automated computer simulation for synergism and/or antagonism at any effect and dose level

41 ntified concurrent variations that maximized synergism, and examined the ways in which it was affecte

42 ptosis induced by serum starvation, cytokine synergism, and glucolipotoxicity, through phosphatidylin

43 better understand their mechanisms, possible synergisms, and specific risks.

44 f developmental and anatomical traits; trait synergisms; and (interspecies) root competition.

45 combinatorially with documented examples of synergism, antagonism and redundancy.

46 ach for successive relapses considering drug synergism are highlighted.

47 ombined blockade, details of CXCR3 and CXCR4 synergism are not understood.

48 documented, the mechanisms that govern this synergism are poorly understood.

49 Although both mechanisms of synergism are used in parallel, the contribution of conv

50 The apparent functional synergism arising from TRPM8 activation and M-current bl

51 n incorporation with antagonism switching to synergism at higher doses, while the CA model indicated

52 To evaluate potential synergism at lower concentrations (near or below 1 part

53 at fails to capture essential aspects of the synergisms at highly active Ni-Fe sites.

54 Finally, a synergism between Abeta/APP and human tau seems to be re

55 )-specific antibody, we define a therapeutic synergism between ALK and IGF-1R inhibitors.

56 Previously, we have shown that statistical synergism between amino acid variants in thyroglobulin (

57 Synergism between amino acids and tocopherols was demons

58 ol neutrophils, but there was no evidence of synergism between AMX and neutrophils.

59 tanding of the mechanisms by which the early synergism between antibody-mediated toxin neutralization

60 nt potential of bread; however, caffeine and synergism between antioxidants are also important consid

61 oxicity of the mixture, as well as potential synergism between arsenic and manganese.

62 Our results reveal synergism between auxin transport and signaling, and the

63 ys, the latter confirming strong to moderate synergism between B2088 and various classes of antibioti

64 n cross-linking, prompting us to investigate synergism between beta-lactams and DCS.

65 nce that uniquely human cognition depends on synergism between both representational and motivational

66 The results revealed substantial synergism between BRGA and RHL/D.

67 nstrated that metabolic and glucan-dependent synergism between C. albicans and S. mutans contribute t

68 Finally, synergism between C12/C14 and POS were confirmed by time

69 nium chloride is used with the BTU receptor, synergism between C4P and Aliquat 336 is so pronounced t

70 Strong pharmacological synergism between CAF and HAL is demonstrated in both si

71 Highlighted in this Perspective are the synergism between calculations and experiments in the au

72 tion between CBM-linker and Trp-38 indicates synergism between CBM-linker and CD in feeding the cellu

73 aptive value of beneficial mutations through synergism between cell-to-cell variability and genetic v

74 Synergism between CHK1 inhibition and RRM1-dependent gem

75 ant e-e mixing, thus reaching a new level of synergism between computational and formal treatments.

76 Indeed, the synergism between cryogenic electron microscopic and X-r

77 This includes specific synergism between cytokinin and salicylic acid pathways

78 RATIONALE: The relative actions and synergism between distinct myocardial-derived stem cell

79 ng or timing treatment schedules to optimize synergism between drugs.

80 t especially under low food, the strength of synergism between esfenvalerate and prochloraz increased

81 Possible synergism between female sex hormones and vitamin D on p

82 This bidirectional synergism between fly genetics and human genomics facili

83 We find a synergism between function of the PEPR and Flagellin Sen

84 In addition, we discovered synergism between hBD-3 and LL-37 in killing S. aureus.

85 n is one of the molecular mechanisms for the synergism between HCV and alcohol abuse in liver disease

86 In blood cancers, the synergism between HIF overexpression and stabilization w

87 Based on the synergism between histone deacetylase inhibitors and hyp

88 Our data provide strong evidence of synergism between IFN-gamma and TNF- alpha in inflammato

89 l models, which can illustrate the potential synergism between immune checkpoint inhibitors and radio

90 These results suggest synergism between increased RyR sensitivity and decrease

91 bserved under any other condition suggesting synergism between increased RyR sensitivity and decrease

92 We investigated the synergism between influenza virus and Streptococcus pneu

93 We investigated synergism between inositol 1,4,5-trisphosphate (Ins(1,4,

94 The synergism between ISC-4 and cetuximab was retained indep

95 We observed evidence of synergism between lead and manganese, whereby lead toxic

96 The potential synergism between ligand and reductant for iron (hydr)ox

97 This study investigated the potential synergism between ligands (desferrioxamine B (DFOB) or N

98 The synergism between light and heat shocks was deficient in

99 The synergism between low-frequency sonophoresis (LFS) and c

100 wards higher free NADH suggesting a possible synergism between metabolic dysfunction and transcriptio

101 Second, the well-known synergism between metals and warming was manifested not

102 gs highlight the potential of exploiting the synergism between miR-9/9*-124 and transcription factors

103 This study shows that modular synergism between miRNAs and neuronal subtype-specific t

104 +)-handling defect is the result of negative synergism between mitochondrial depolarization and alter

105 These results do not provide evidence for synergism between mutation and stress.

106 ty provides preliminary clinical evidence of synergism between olaparib and alpelisib, particularly i

107 antioxidant activity is also related to the synergism between other minor compounds found in the EO.

108 Our findings support synergism between PI based desensitization and belatacep

109 er, these findings suggest that antileukemic synergism between PI3K/AKT/mTOR inhibitors and BH3 mimet

110 nventional mechanistic interpretation of the synergism between randomly acting endoglucanases (EGs) a

111 recombination, a possibility consistent with synergism between recG and ruv null alleles and reinforc

112 research provides epidemiologic evidence for synergism between rotavirus and other enteric pathogens.

113 gree to which this improvement may represent synergism between sorafenib and doxorubicin remains to b

114 ion groups with each other, and there was no synergism between text messages and calls.

115 d murine tumors, which reveals an unexpected synergism between the autophagy pathway and p62 in drivi

116 Our results indicate a synergism between the base excision repair pathway and d

117 ivation mechanism, and previously unexpected synergism between the covalent and non-covalent ubiquiti

118 study, we extend this principle to a strong synergism between the dectin-1 agonist curdlan and an in

119 might give rise to the behaviorally observed synergism between the direct/indirect pathway neurons.

120 Thus, our work identifies a synergism between the DNA methylation and Aurora kinase

121 plasmid encoding MdtM suggested a functional synergism between the single-component MdtM transporter

122 t osteoinductive agent (BMP-7), suggesting a synergism between the soluble factor and GJIC.

123 ecrosis factor-alpha (TNF-alpha), suggesting synergism between the two cytokines.

124 the hot plate test to determine if there is synergism between the two drugs in reducing pain.

125 rated a FIC index of <0.5, suggesting strong synergism between the two drugs.

126 ty of individual ASL antimicrobials, impairs synergism between them, and thus may disrupt an importan

127 ole in southern-AF than northern-AF, and the synergism between thermal and water-related conditions i

128 To investigate potential synergism between these factors, we used a global proteo

129 redicted to be the best strategy to maximize synergism between these two drugs.

130 her, its expression is required for the full synergism between these two pathogens.

131 o Cry2Ab caused by selection with Cry1Ac and synergism between these two toxins against resistant ins

132 d higher than expected mortality, reflecting synergism between these two toxins.

133 More importantly, we uncovered genetic synergism between Twist1 and the ETS family transcriptio

134 Synergism between two crystal growth modifiers is expect

135 iencies in innate immunity and evidence of a synergism between viral infection and allergic mechanism

136 equired for cancer progression, indicating a synergism between VP-16 treatment and the loss of Star-P

137 Synergism between WAFAPA and MYPGLA was detected.

138 several inhibitors with tungstate, and found synergism between WO(4)(2-) and NO(2)(-), while additive

139 The authors prospectively evaluated synergisms between effects of arsenic exposure and those

140 Lastly, we identified strong pharmacological synergisms between FPPa-OmoMYC and chemotherapeutic agen

141 However, little is known about potential synergisms between halide and nitrate ions.

142 t C/EBPalpha plays an important role in such synergism by directly interacting with PXR; enhancing RI

143 Synergism can be explained by a simple and general mecha

144 ive definition for additive effect (CI = 1), synergism (CI < 1), and antagonism (CI > 1) in drug comb

145 ompounds from GCB and WF demonstrated slight synergism (CI=0.92), while potentially bioaccessible and

146 instead of valine in B2088) displayed better synergism compared to other substitutions.

147 is of this combination demonstrated superior synergism, compared with each individual treatment at lo

148 re (S)-selective, which points to pronounced synergism (cooperative nonadditivity) when they interact

149 five lead compounds were examined for their synergism/cooperativity with five clinical drugs against

150 EGF-C-induced angiogenic and lymphangiogenic synergism could be potentially important approaches for

151 Expression of synergism demands that an enzyme display low basal activ

152 The strength of the synergism depended on the particle acidity and water con

153 We show that cellular G(i)-G(q) synergism derives from direct supra-additive stimulation

154 rimary arylamine group is indispensable, but synergism due to hydrophobic contacts between the rest o

155 mpaired upon miR-125b repression, suggesting synergism during leukemic transformation in GATA1s-mutat

156 studied for the first time whether a similar synergism exists between P11L and three other mutations

157 To determine the specificity of this synergism, Exp.

158 This synergism extended to androgen-sensitive and androgen-in

159 Only a subset of architectures exhibited synergism following paired changes in parameters.

160 teraction, and the possibility of using such synergism for gene therapy applications.

161 on suggested an additive effect and moderate synergism for NPS-OA.

162 The effects of motifs on synergism for this biologically realistic model were con

163 icistronic reporter mRNA revealed functional synergism for translation efficiency.

164 ver, characterizing the underlying molecular synergisms for the combination of drugs remains a challe

165 Accordingly, synergism has been observed between DNA-damaging drugs a

166 This synergism, however, does not appear at the input level o

167 There was no evidence of synergism (i.e., excess risk due to interaction) between

168 as in REM sleep for memory consolidation and synergism in awake states for cognitive control.

169 This may be attributed to a pertinent synergism in between the positively charged functionaliz

170 xpressed in these same cells, accounting for synergism in double mutants discovered almost 100 years

171 Isobologram analyses showed synergism in dsRNA combinations (CI=0.4-0.82) vs. an add

172 ions suggest the evolution of AMP/Fru-2,6-P2 synergism in eukaryotic FBPases from an ancestral FBPase

173 m to the central cavity and the evolution of synergism in FBPases.

174 D decreases LT protein levels and eliminates synergism in MCV DNA replication as well as sT-induced c

175 This synergism in mixtures containing an azole has mostly bee

176 AMP/Fru-2,6-P2 synergism in pFBPase is absent in eFBPase.

177 tend earlier observations of organophosphate synergism in salmon and reveal an unusually steep concen

178 lly patterned and that, in contrast to their synergism in shoots, BR and auxin interact antagonistica

179 ence information indicates the likelihood of synergism in the FBPase from Leptospira interrogans (lFB

180 e first glimpse into the citrate-transferrin synergism in the regulation of Ti(IV) bioactivity and of

181 NRM in vivo also produced a PLA(2)-dependent synergism in their antinociceptive effects.

182 fectively coupled, can result in significant synergism in their electrical, mechanical, and biocompat

183 d Cap with a combination of siTNFalpha shows synergism in treating skin inflammation.

184 ion posaconazole-tacrolimus therapy displays synergism in vitro and improved antifungal efficacy in v

185 the PARP-1 inhibitor PJ34 were assessed for synergism in vitro by combination-index analysis in SK-N

186 mmunity development, which can contribute to synergisms in litter decomposition.

187 s to investigate pharmacological evidence of synergisms in nicotinic/muscarinic interactions on cogni

188 ent dynamics and interactions (antagonism or synergism) in a nutrient-poor greenhouse soil.

189 oot elongation was more than additive (i.e., synergism) in soils with high and medium cation-exchange

190 Therapeutic drug synergism intervened in cancer treatments has been demon

191 The synergism is attributed to the effective intratumoral bu

192 The synergism is attributed to the remarkably 30-70x higher-

193 Such synergism is commonly assumed to be complex, requiring r

194 Whereas synergism is comparatively weak when either methyltri(C(

195 This powerful synergism is explained by blockade of a P2Y12 receptor-d

196 ough DNA methylation, and that the degree of synergism is increased in cells lacking functional BRCA2

197 The absence of synergism is likely the result of stressor treatments th

198 Additionally, we uncovered that this synergism is mediated through Gi, protein kinase G, and

199 wheat straw suggested that this mechanism of synergism is operative also in the degradation of lignoc

200 Synergism is quantitatively explained by the classical a

201 This synergism is reduced by the RNA polymerase mutations ide

202 e of the identifying that the origin of this synergism is the increased penetration and subsequent di

203 The two-state mechanism also explains why synergism is unique to PLC-beta3 among the four PLC-beta

204 d so-called "competing response types," with synergism itself conceived of as causal co-action within

205 t higher doses, while the CA model indicated synergism, mainly driven by effects at high doses of gam

206 Phene synergism may be common in plant biology and can have su

207 These synergisms may enable 'special' tolerance of intracellul

208 efore, we hypothesized that this statistical synergism mirrors a biochemical interaction between Tg p

209 et, providing a possible explanation for the synergism observed between these two compounds.

210 The neutralization synergism obtained when pooling the most potent HMAbs co

211 tively predicted and ranked the efficacy and synergism of all possible combinatorial inhibitions of e

212 r enhanced activity, selectivity, and mutual synergism of antimicrobial biosurfactants and reduced de

213 echanistically, we provide evidence that the synergism of ATRA and FLT3 TKIs is at least in part due

214 can be involved with the reported behavioral synergism of D1R and D3R agonists.

215 We conclude that the synergism of IL-1beta and IFN-gamma to induce expression

216 and likely pretibial myxoedema) involves the synergism of insulin-like growth factor 1 receptor (IGF1

217 ivation of T cells and required a tripartite synergism of interferon-gamma, tumor necrosis factor and

218 The synergism of large surface area, multiscale porous struc

219 This synergism of Msx1 with Pax9 is significant, because it i

220 ly complex diseases with the interaction and synergism of multiple genetic and environmental factors.

221 Results of mixture tests showed a strong synergism of the identified aromatic amines not only wit

222 The reported synergism of the precursor spectinomycin with other anti

223 Synergism of these drugs can be attributed to their acti

224 ir pollutant exposure, which may be due to a synergism of these factors acting on innate immune recog

225 study provides a molecular mechanism for the synergism of tumor microenvironmental conditions in canc

226 707 (1 mum) and OMDM-2 (5 mum), a functional synergism on cellular AEA and 2-AG uptake was observed.

227 ents in complex hormone disease networks and synergism or antagonism between pathways.

228 e volatile oils and verify the occurrence of synergism or antagonism between them.

229 ly depending on the polarity, mild to strong synergism or antagonism was observed by combining ecdyst

230 nteraction are sometimes used to assess such synergism or mechanistic interaction, but testing for po

231 Synergism (or antagonism) was quantified using degrees o

232 We performed dose-response, synergism, P-glycoprotein inhibition, and pharmacokineti

233 To examine this food synergism, papaya and strawberry nectars and their respe

234 found that epinephrine signaling changes the synergism pattern and decreases efficacy of combination

235 The synergism requires Snf1 and Adr1 but not Cat8.

236 Synergism requires the presence of both Smad and AP-1 re

237 In a narrow pH range around 2.5 the synergism resulted in a 10-fold higher survival rate.

238 The synergism results from LfcinB-mediated activation of Sp1

239 ve action between GRs may further add to the synergism seen in germination triggered by multiple GRs.

240 The strong synergism seen with paclitaxel and everolimus was then e

241 NCPD displays much stronger synergism than its free drug counterpart, which suggests

242 the case when two or more species exhibit a synergism that produces a disease state not seen with an

243 This provides two types of synergism that strongly potentiated cAMP-mediated fluid

244 n their mechanism of action and screened for synergism to improve Gram-negative bacterial coverage.

245 plored here is the linkage of AMP/Fru-2,6-P2 synergism to the central cavity and the evolution of syn

246 ons ranges from cooperation and coexistence (synergism) to mutual exclusion (antagonism).

247 de "synergy under recoding of an exposure," "synergism under recoding of the outcome," and so-called

248 e triple combination showed a high degree of synergism, unprecedented for in vivo HIV-1 PrEP, leading

249 sional dynamics and ecological interactions (synergism versus competition) between populations in PB-

250 at locust mortality increased as a result of synergism via a mechanism related to Ca(2+) disruption i

251 much more magnified by the heat spike and a synergism was already detected at the low concentration

252 The synergism was already evident for the tendency for radic

253 This synergism was also evident at the protein level, with in

254 This synergism was also not seen between the germinant L-vali

255 However, synergism was also observed as in the case of D. magna e

256 On the other hand, this synergism was attenuated by disrupting the C/EBP binding

257 Synergism was demonstrated when extracts were combined w

258 Synergism was determined by calculating fractional inhib

259 bited XO, and for their combination moderate synergism was found.

260 Also, the synergism was independent of Chk2 both in Chk2-complemen

261 This synergism was not observed with the reverse treatment or

262 lower concentrations, and a modest degree of synergism was observed at higher concentrations.

263 However, synergism was observed between HELZJ and the antibiotics

264 A similar synergism was observed between physiological concentrati

265 Synergism was observed more frequently in H. bacteriopho

266 however, when combined with TMZ, significant synergism was observed, resulting in cell cycle arrest a

267 istically; however, after digestion in vitro synergism was observed.

268 Synergism was obtained for the binary mixtures of (TOH+A

269 However, synergism was only observed for prochloraz at environmen

270 The inter-domain synergism was pre-requisite for the efficient degradatio

271 single stimulation in U-CLL, whereas BCR/TLR synergism was required in M-CLL, in which the effect was

272 ects were observed at the lower doses, while synergism was seen at the highest doses.

273 Similar synergism was seen with agents targeting Akt in combinat

274 Synergism was the main effect observed among the tested

275 for therapeutic resistance and the switch in synergism were explored by analyzing a network model of

276 Accordingly, synergisms were only seen in leukemia cells expressing w

277 more, these antibodies elicit robust in vivo synergism when combined with oseltamivir, thus highlight

278 at a time, but interact cooperatively and in synergism when rats concurrently learn two types of task

279 We propose a mechanism of endo-exo synergism whereby the degradation of amorphous regions b

280 ose a molecular mechanism based on PARP1-Erk synergism, which may underlie this phenomenon.

281 le and triple mutations significantly reduce synergism while retaining other wild-type kinetic proper

282 shedding light on its potential mechanism of synergism with afatinib.

283 Along with known synergism with bright light, the above PRCs with a secon

284 P-response element, and C/EBP half-sites, in synergism with C/EBP family members, whereas the MMP13 p

285 ration-resistant prostate cancer (mCRPC) and synergism with docetaxel.

286 ecific inhibitor bicyclomycin failed to show synergism with either aza-C or streptolydigin.

287 finity, on- and off-rates, processivity, and synergism with endoglucanase.

288 SHS exposure has dose-dependent synergism with family history of asthma, the joint effec

289 key source of CCN1-induced ROS critical for synergism with FasL.

290 In addition to a direct antiviral effect and synergism with IFN, the SOCS antagonist also exhibits ad

291 Strikingly, # 6513745 displayed synergism with isoniazid against M. marinum in murine ma

292 o abrogate cell-cycle inhibition and produce synergism with LMP-400.

293 anti-malarials, we observe growth inhibition synergism with low doses of this beta2-selective inhibit

294 This synergism with mixtures of nutrient germinants was not s

295 res exploration, particularly in view of the synergism with other phytochemicals.

296 n skipping may constitute a key strategy for synergism with other splicing regulators in establishing

297 ts in an apparently mechanistically distinct synergism with quinine and with piperaquine.

298 colony formation revealed that LCA exhibits synergism with the alkylating agent temozolomide, which

299 IFN-beta in RelA(-/-) MEFs, transcriptional synergism with the coactivator CREB-binding protein, and

300 es via butyrate production, or contribute to synergism within a consortium by heterogenous polysaccha

301 anistic interaction is often conceived of as synergism within Rothman's sufficient-cause framework.