ライフサイエンスコーパス: synergistic

1 t of As, while Cd/As(mix) joint toxicity was synergistic.

2 ation of the transmembrane domain (TMD) from synergistic 5-HT binding.

3 o is required for oogenesis and for in vitro synergistic actin assembly.

4 s modest, cefazolin plus ertapenem exhibited synergistic action in a rat model of MSSA endocarditis.

5 lar anticancer and antifungal activities and synergistic action in combination with cisplatin and amp

6 Collectively, clearance and synergistic action of all these gating checkpoints are r

7 dary, which becomes further dysbiotic by the synergistic action of bacterial communities.

8 The synergistic action of outer membrane permeability, efflu

9 The synergistic action of the chiral copper catalyst, Lewis

10 DEI was ignited by synergistic actions of constructing nanoheterojunctions

11 Besides, it has been observed that the synergistic actions of enzymes improved the biological a

12 hydrolyse polymeric arabinoxylan while their synergistic actions successfully modified its structure

13 l binding site of aryl sulfonamides may have synergistic actions.

14 n of EMT genes, we employed the CRISPR/dCas9 Synergistic Activation Mediator (SAM) system, which indu

15 Our structure explains the synergistic activation of cohesin by NIPBL and DNA and p

16 nal validation revealed these dGBMs conveyed synergistic activation of Gli targets essential for mand

17 dopamine-denervated striatum, resulting in a synergistic activation of PLC signaling by D1 and mGlu5

18 With three synergistic active sites, Hf(12) -Ru-Co-OTf competently

19 Here we report that synergistic activities of 15-lipoxygenase (15-LO) and se

20 rious drug combinations by quantification of synergistic activities.

21 multitargeted anticancer agent may result in synergistic activity of its components.

22 ate >1700 mumol g(-1) h(-1) generated by the synergistic activity of the two composite costituents.

23 rs within the 1.45 Mb cluster exhibit highly synergistic activity that is dependent on the Coordinato

24 ligands to PDK1 reveal multiple hotspots of synergistic allostery with cumulative effects greater th

25 bility, multivalency, complex heterogeneity, synergistic alphaalpha-hub:ligand folding, accessory bin

26 Our findings suggest that synergistic alterations of gut microbial consortia, rath

27 This possible synergistic ameliorating effect is achieved through the

28 In preclinical mouse models, a synergistic anabolic response to PTH(1-34) and tibia loa

29 ocking and step pinning(12,13), exhibit both synergistic and antagonistic cooperativity depending on

30 Thus, our ability to rapidly identify synergistic and antagonistic drug interactions can poten

31 mensal bacterial groups and showed different synergistic and antagonistic effects in combination with

32 We also highlight that synergistic and antagonistic effects occur concurrently,

33 , could be valuable for better understanding synergistic and antagonistic effects relevant for stabil

34 lved in the hydrocarbon phase, can have both synergistic and antagonistic effects, depending on their

35 edict singular versus combinatory effects of synergistic and antagonistic factors on chromatograph ar

36 Synergistic and antagonistic interactions between stimul

37 The networks of multiple synergistic and antagonistic interactions within oral bi

38 The 19-CAR and ML responses were synergistic and CAR specific and required immunoreceptor

39 oteins, where activating proteins tend to be synergistic and deactivating proteins tend to be competi

40 liganded enzyme targets is bidirectional and synergistic and offers a strategy for combinatorial drug

41 tween 171 miRNA-binding sites and identified synergistic and redundant effects.

42 herefore better able to discriminate between synergistic, antagonistic, and additive interactions.

43 with robust stability, high drug loading and synergistic anti-cancer efficacy.

44 ncentration of anionic detergent and exhibit synergistic anti-cancer efficacy.

45 e pro-injurious effects of LPS, suggesting a synergistic anti-inflammatory effect of PS/drug formulat

46 mes of the arachidonic acid cascade leads to synergistic anti-inflammatory effects.

47 in combination with lenalidomide resulted in synergistic anti-MM activity in both in vitro and in viv

48 oth PI3K and RAS signaling, thereby exerting synergistic anti-tumor effects on ovarian cancers with P

49 iruses is a promising strategy for achieving synergistic anti-tumor efficacy with improved safety pro

50 The substrates exhibited a synergistic antioxidant effect when combined with commer

51 blocks EGFR and STAT3 signaling, and exerts synergistic antitumor activity both in vitro and in vivo

52 DNA damage inducing chemotherapy resulted in synergistic antitumor activity.

53 In summary, this study presents a synergistic antitumor combination of PDI and HDAC inhibi

54 Photoirradiation of EA-BPS induces a synergistic antitumor effect that results from the combi

55 th nocodazole (to induce mitotic arrest) had synergistic antitumor effects in vitro, with minimal eff

56 d NSCLC cells to chemotherapy and produced a synergistic antitumor response in vitro and in vivo.

57 These findings serve as proof of concept of synergistic antitumour activity with the combination of

58 ffect of TMNP, we concluded that TMNP causes synergistic apoptosis and necrosis along with cell cycle

59 A successful simulation strategy requires a synergistic approach that balances between the three fie

60 To impart both intricacy and security, a synergistic approach was implemented resulting in both o

61 These synergistic approaches range from Go and related structu

62 ife were associated with clinical CVD with a synergistic association with outcome (P(interaction)=0.0

63 s to prevent cardiovascular disease can have synergistic benefit in preventing other diseases and imp

64 MAPK pathway, was evaluated and demonstrated synergistic benefit.

65 eting inflammasomes and complement may offer synergistic benefits to inhibit CNV.

66 enhanced systemic FC acceptor capacity, has synergistic benefits.

67 new alloy design and production path that is synergistic between additive manufacturing and dispersio

68 o the peptidyl tRNA-binding site and towards synergistic binders that occupy the nascent peptide exit

69 iological barriers and leveraging on several synergistic cancer cell killing mechanisms.

70 Synergistic cell death was observed with c-MET inhibitio

71 ibitor buthionine sulfoximine (BSO) leads to synergistic cell growth inhibition.

72 Synergistic co-activation does not require preexisting a

73 Here, we use a synergistic combination of a chemical force (hydrogen bo

74 Additional studies showed a synergistic combination of PI3K-alpha/delta inhibitors w

75 We used a synergistic combination of total internal reflection flu

76 nd that the transcriptional signature of the synergistic combination was unique relative to that of e

77 re moving toward the evaluation of potential synergistic combinations.

78 ents in obtaining it, and the ability of our synergistic computational-experimental approach to "de-r

79 romoted cell proliferation, and improved the synergistic cytotoxicity of treatment with the alkylatin

80 dent on autophagy for survival and displayed synergistic cytotoxicity with the poly (ADP-ribose) poly

81 spectroscopy of late passage MSC indicated a synergistic decrease of actin and microtubule cytoskelet

82 rs of both transcription factors resulted in synergistic decreases in cell growth in cell lines and p

83 ic-Acid Speech (NuSpeak), two orthogonal and synergistic deep learning architectures to characterize

84 hermore, combining the mutations resulted in synergistic defects in RNA packaging, suggesting redunda

85 Silicon amendment induces the synergistic defense mechanism by significantly increasin

86 We find that synergistic delivery of dCas9 effectors is highly select

87 s study, we discover that Aurora kinases are synergistic determinants of a switch from the proliferat

88 practices by sharing experiences and making synergistic discoveries about what works.

89 giogenesis as the key events and potentially synergistic drivers associated with CRC metastasis.

90 aining an AUROC of 0.77 in the prediction of synergistic drug combinations in an independent dataset.

91 l mechanisms leads directly to the design of synergistic drug combinations, which we validate systema

92 ization to maximize drug cytotoxicity and/or synergistic drug interactions.

93 TB strategy manipulating Ison@Man-Se NPs for synergistic drug-induced and phagolysosomal destruction

94 We show that a significant synergistic effect (faster decomposition in mixtures tha

95 ation with chemotherapy, which can achieve a synergistic effect and a decrease in chemoresistance.

96 m of the present work was to investigate the synergistic effect between antibodies directed toward di

97 cell proliferation of WT MEFs, suggesting a synergistic effect between CARM1 and PRMT6 inhibitions.

98 gin or anti-PD-1 therapy alone, indicating a synergistic effect between PD-1 inhibitors and immunomod

99 The synergistic effect between RB and C(KLAKLAK)(2) has been

100 5 as mediated through SETD1, suggestive of a synergistic effect between SETD1 and p65 in the modulati

101 here the growth kinetics are controlled by a synergistic effect between strain and entropy.

102 activity of metallic atoms and enhancing the synergistic effect between the inner selenides and surfa

103 ectronic structural features suggests that a synergistic effect between the ligand and cobalt in Co(I

104 igand-functionalized NPs, we showcase here a synergistic effect between these two NP types during the

105 A synergistic effect by methyljasmonate (MeJA) and by comp

106 e on propranolol's efficacy was opposite the synergistic effect hypothesized a priori.

107 The synergistic effect in combination with bortezomib and an

108 ent with IL-17RB-neutralizing antibody has a synergistic effect in combination with gemcitabine for k

109 reatments using combinations of drugs with a synergistic effect is attractive but proves to be highly

110 ion hydrogel to maintain ADSC functions, the synergistic effect of AM with ADSC in preventing the cat

111 The results also showed that the synergistic effect of AM-ADSCs was more pronounced in pr

112 s including cirrhosis suggesting a potential synergistic effect of cardiac dysfunction on fibrosis ri

113 Synergistic effect of combining D-amino acids with Cip w

114 Factorial analysis suggested a synergistic effect of combining nutrition education and

115 Furthermore, we find that the synergistic effect of inhibiting both mitochondrial tran

116 Due to the likely synergistic effect of N dopant and V(O) , the V(O) -rich

117 duction of rice has been elucidated, and the synergistic effect of nZVI treatment and rice cultivatio

118 ildren as the reference group, we observed a synergistic effect of overweightness and early pubertal

119 The synergistic effect of selective aptamers & high sensitiv

120 es lithium dendrite growth but also brings a synergistic effect of storing lithium via a reversible t

121 we here demonstrate, for the first time, the synergistic effect of the combination of DMAP/HCl/Schrei

122 vitro studies in porcine skin confirmed the synergistic effect of these strategies in enhancing epid

123 Furthermore, a synergistic effect on breast cancer (MCF-7) and melanoma

124 However, LDL did not exert a synergistic effect on HDL cholesterol efflux capacity in

125 ntially by the same stimulus, which exerts a synergistic effect on PDCD4 expression and thereby helps

126 A synergistic effect on phage restriction was observed whe

127 ion of TET1 and a VP64 transactivator have a synergistic effect on the reactivation of the inactive a

128 First principle simulation reveals this synergistic effect originates from the unique Fe-Cu coor

129 Due to the synergistic effect originating from the conjugated inner

130 role in the enhanced disinfection, while the synergistic effect presented a greater contribution, whi

131 Their apparent synergistic effect reported in previous observational st

132 tability of the WW domain due to a favorable synergistic effect that depends on the hydrophobicity of

133 d the enantiopure comonomers, highlighting a synergistic effect upon coassembly of the three monomers

134 omolar concentrations (0.019-1.83 muM) and a synergistic effect was achieved when Methylene Blue was

135 ed the permeability of IEC monolayers, had a synergistic effect when knocked down from both cell type

136 e the CyRPA/RIPR combination showed a modest synergistic effect with Hewlett's [Formula: see text] Ad

137 CPPB displays a strong synergistic effect with paclitaxel against growth-inhibi

138 sociated with severe periodontitis and has a synergistic effect with poor oral hygiene, suggesting mo

139 ality litter in mixtures shows a significant synergistic effect, while additive effects are observed

140 absorbed more N) within mixtures, a possible synergistic effect, while Iris ensata 'Rising Sun' perfo

141 together with IL-4 failed to demonstrate any synergistic effect.

142 defects, and loss from both cell types has a synergistic effect.

143 e recognition process, resulting in a strong synergistic effect.

144 inhibitory CSPGs did not have a significant synergistic effect.

145 Additionally, we observed weaker synergistic effects at a distal GHI-subdomain locus.

146 feeds and eyestalk ablation and reveal their synergistic effects at the transcriptomic level through

147 Synergistic effects between nsPEF and the moderately ele

148 The synergistic effects between the polychaete feeding and t

149 es in different LHCEs indicate the intrinsic synergistic effects between the salt and the solvent whe

150 on was most likely the result of additive or synergistic effects caused by several compounds.

151 The multiple synergistic effects empower the electrocatalyst with exc

152 us a platform to unambiguously screen the M synergistic effects in improving the electrocatalytic ac

153 ine which species are most vulnerable to the synergistic effects of climate change and habitat loss i

154 Synergistic effects of depressive disorder and NR3C1 hyp

155 ect on the alpha-FAPbI(3) phase owing to the synergistic effects of epitaxial stabilization and strai

156 n thoroughly studied in various aspects, the synergistic effects of feeding with live feeds and the a

157 to any individual antibiotic or require the synergistic effects of several antibiotics, we treated m

158 nist mixtures is due to additive rather than synergistic effects of the specific antagonist combinati

159 improves functional outcome in mice with no synergistic effects of the used EphA4 targeted therapy.

160 elength from 300 to 750 nm demonstrating the synergistic effects of two different polymers.

161 Our results highlight the potential for synergistic effects of warming and biodiversity loss on

162 sults showed that N and CO(2) enrichment had synergistic effects on alpine grassland communities.

163 of targeting RNPs in the same nanoparticle, synergistic effects on lipid metabolism are observed in

164 tion gave higher efficacy of CO(2) indicated synergistic effects on melanosis and TMA inhibition.

165 Obesity and air pollution may have synergistic effects on the development of DSPN.

166 dings thus suggest that the RBD and CRD have synergistic effects on their membrane dynamics, with CRD

167 lin receptor attenuated pAkt T308 and showed synergistic effects on viability.

168 Genetic analyses indicate that eno exhibits synergistic effects with mutations at the LOCULE NUMBER

169 sponses (that is, additive, antagonistic and synergistic effects).

170 ess, and goblet cell metaplasia, without any synergistic effects.

171 in the MIC of the antibiotic, demonstrating synergistic effects.

172 wise and contends that both pathologies have synergistic effects.

173 mbined inhibition of p300/CBP and BET showed synergistic effects.

174 oups within a framework, leading to emergent synergistic effects.

175 y of combinatorial cell populations exerting synergistic effects.

176 totherms with the potential for detrimental, synergistic effects; yet, effects of these stressors rem

177 o be used directly in unbiased evaluation of synergistic efficacy in drug combinations using probabil

178 igned mesoporous silica nanoformulation with synergistic efficacy in subcutaneous and orthotopic PDAC

179 with robust stability, high drug loading and synergistic efficacy is a promising strategy for effecti

180 Preclinical trials in the model demonstrate synergistic efficacy of immune checkpoint blockade with

181 dicates that SARS-CoV-2 control requires the synergistic efforts of case isolation, contact quarantin

182 >100 mg As/g adsorbent), and during release, synergistic electrocatalytic oxidation of As(III) to As(

183 mometric classification analysis showed that synergistic enzymes' actions were predominantly responsi

184 This synergistic ethanol * saliva effect is attributed to the

185 The synergistic ETV5/c-Myc activation disappeared when hTERT

186 Our synergistic experimental and computational work demonstr

187 stituent, and type of reducing agent using a synergistic experimental-computational approach.

188 These three synergistic factors influence the nucleation and growth

189 y, knowledge of the specific, redundant, and synergistic functions of helper RNLs is limited.

190 ency with obesity and/or diabetes leads to a synergistic further impairment of endothelial and gut ba

191 This establishes multivalent, synergistic H3-tail binding causing distinct cellular lo

192 ed to the crystal structure and demonstrated synergistic HDX changes focused around the N221 and N255

193 However, the mechanism of this synergistic ILC2 activation is unknown.

194 e immuno-NP stems from its dual cargo of two synergistic immune modulators consisting of an agonist o

195 atures for photosynthesis, implying that the synergistic impacts of warming and biodiversity loss on

196 eterogenous catalysis, leading to remarkable synergistic impacts on activity and selectivity.

197 Synergistic improvement in leaf photosynthetic area and

198 e fusion to enhance mRNA release, leading to synergistic improvement of mRNA delivery.

199 ition of MTAP alongside SSAT upregulation is synergistic in androgen sensitive and castration recurre

200 ase in intracellular pyruvate and was highly synergistic in decreasing neuroblastoma cell viability.

201 ripheral blood mononuclear cells (PBMCs) and synergistic in human FLT3-differentiated mBMDCs and CAL-

202 were partially additive in LP and COMBO, and synergistic in MP media.

203 ple combinations of BH3 mimetics were highly synergistic in restoring killing of CLL cells.

204 a-lactam (BL) to daptomycin (DAP) results in synergistic in vitro activity against methicillin-resist

205 n and CCNE1-amplified models, correlate with synergistic increases in replication fork stalling, doub

206 patible with either defect but causes strong synergistic increases in the mutation rate, indicating t

207 nes by their relevance-the individual gene's synergistic influence in a gene-to-gene interaction netw

208 The synergistic influence of sample flow rate and various el

209 dium fluoride (TA-NaF), which exhibits clear synergistic inhibition of ammonia production in pure bac

210 r CD437 combined with CHK1 inhibitors led to synergistic inhibition of cancer cell proliferation.

211 The drug combination induced synergistic inhibition of proliferation, as well as enha

212 obial inhibitor, and we hypothesize that the synergistic inhibitory effect on ammonia production is r

213 ec-11 and Siglec-11-derived peptides offered synergistic insight into ligand binding.

214 The synergistic integration of nanomaterials with 3D printin

215 ectedly, Nodal signaling is a major point of synergistic interaction between Cdon mutation and fetal

216 Previous work by Cory's group pointed to a synergistic interaction of MYC and MNT in neoplastic B-c

217 ence of depressive disorder with significant synergistic interaction terms and independent of potenti

218 Nano-11 and cdAMP demonstrated a strong synergistic interaction, as shown in the activation of m

219 n with itraconazole displayed broad-spectrum synergistic interactions against Candida albicans, Candi

220 chronic metabolic syndrome through potential synergistic interactions among different components is i

221 conceptual model is proposed to describe the synergistic interactions among different stress agents a

222 Pitavastatin displayed broad-spectrum synergistic interactions with both fluconazole and voric

223 We consider both cumulative impacts and synergistic interactions with other anthropogenic pressu

224 tures; and (iii) the search for higher-order synergistic interactions.

225 ous biomolecules via multivalent, hybrid and synergistic interactions.

226 nd molecular dynamics simulations reveal the synergistic interfacial interaction mechanisms of Ti-O-C

227 ing chimera reduced c-Myc levels and exerted synergistic lethality in BETi-P/R sAML cells.

228 studies show Li and Mn working together in a synergistic manner to facilitate both the Mn-I exchange

229 neutralized wild-type SARS-CoV-2 virus in a synergistic manner.

230 r sensitized PCa epithelia to docetaxel in a synergistic manner.

231 phabeta-tubulin assembly in an additive, not synergistic, manner.

232 s with rodent astrocytes results in mutually synergistic maturation, and that cell type-specific expr

233 We studied the synergistic mechanism of equimolar mixtures of magainin

234 to better suppress the HCC cell growth via a synergistic mechanism that may involve suppressing the e

235 Overall, these nonredundant synergistic mechanisms endowed T cells with improved eff

236 d over the years to discover new targets and synergistic mechanisms of action including multicellular

237 t vancomycin-resistant organisms through two synergistic mechanisms of action, both independent of d-

238 (CTLA-4), which limit T cell activation via synergistic mechanisms.

239 on, clusters in lipid membranes that provide synergistic membrane-spanning paths for a rapid and sele

240 created a mathematical bottom-up model for a synergistic mixture effect where we fit a multidimension

241 ibit chemical elimination pathways and cause synergistic mixture effects.

242 ii) the performance of algorithms to predict synergistic mixtures; and (iii) the search for higher-or

243 rphyrinoids, can carry chemotherapeutics for synergistic modalities, and can be enriched with functio

244 Such a job-synergistic mode between catalytic and conductive functi

245 d human clinical data, and in proposing this synergistic model, we highlight dopaminergic afferents f

246 r stages of the disease.IMPORTANCE Given the synergistic nature of TIGIT and PD-1, the coexpression o

247 d 33% resulted in interactive (antagonistic, synergistic, opposing or reversal) effects.

248 The synergistic optimization of bulk and surface properties,

249 ative therapeutics that may disassociate the synergistic or additive association between the infarcts

250 ty under consideration, and may be additive, synergistic or antagonistic.

251 t and panorama of cellular degeneration as a synergistic or overlapping mechanism between ischemia an

252 s (PGRPs) kill bacteria through induction of synergistic oxidative, thiol, and metal stress.

253 ld be achieved in a single batch, due to the synergistic participation of the Ba(2+) and hydroxide io

254 s of these nuclear receptors, evaluate their synergistic pathways and identify their novel modulators

255 ination with reduced Brachyury activity have synergistic posterior body defects, in the strongest cas

256 Synergistic pro-fibrotic effects of TGF-beta were observ

257 pathogen model to consider the combined and synergistic processes used by these microbes.

258 This biosensor, which combines the synergistic properties of both CNTs and AuNPs, represent

259 nanoparticles (NPs) show multifunctional and synergistic properties, which are important for applicat

260 wavelength excitation/absorption bands are a synergistic property of the composite material as they a

261 ell autonomous immune response, and provides synergistic protection with the influenza endonuclease i

262 he peptide-lipid aggregates occurring in the synergistic regime at elevated peptide concentrations.

263 rinciples of miRNAs in NSDs, including miRNA synergistic regulation in NSDs, miRNA modules and NSD mo

264 ally induced skin carcinogenesis through the synergistic regulation of STAT1, STAT3, STAT5, and PI3K/

265 It is critical to note the synergistic relationship among all three of these compon

266 A highly synergistic relationship between PETase and MHETase was

267 PM2.5 exposures and heatwaves appeared to be synergistic (RERIs > 0) for less extreme heatwaves (i.e.

268 arrow-derived dendritic cells (mBMDCs) and a synergistic response in both mouse and human plasmacytoi

269 include enhancement of the high (additive or synergistic reward), compensation for undesired effects

270 Our data enable the development of rational synergistic RLT-combination therapies to improve outcome

271 Taken together, the data herein support a synergistic role for both Abeta and tau in driving neuro

272 rward loops (FFLs) as regulatory motifs have synergistic roles in cellular systems and their disrupti

273 The synergistic roles of the three ion pairs formed by the V

274 inhibited orthotopic liver tumor growth via synergistic SDT/CDT.

275 nwhile, intricate membrane design to realize synergistic separation and some emerging mechanisms are

276 The synergistic steps of design, fabrication, and biomimetic

277 ellular ensembles into living materials with synergistic structure and function remains a considerabl

278 Here, the synergistic superiorities in both activity and stability

279 t dual targeting of JAK2 and SMO resulted in synergistic suppression of breast cancer growth and meta

280 eatment and imaging availability could yield synergistic survival gains for patients with cancer.

281 teins can be combined into a single dose for synergistic targeting to multiple sites of action.

282 f a genomic TRN, providing a snapshot of the synergistic TFs regulatory activity.

283 We argue that this interaction is synergistic: that is, deficits of cognition and reward p

284 t with STAT3 and GR inhibitors could provide synergistic therapeutic efficacy.

285 ine) cationic polymer (PLL) for simultaneous synergistic thermo-chemotherapy treatment and MRI imagin

286 (18)F-FDG PET/CT radiomic features are synergistic to visual assessment of BMI in patients diag

287 ic nCOF composites were cytotoxic due to the synergistic toxicity of Dox and the effects of hyperther

288 In in vivo studies we observe synergistic tumour growth delays and elevated levels of

289 iscuss future directions that will lead to a synergistic understanding of the processes by which m(6)

290 The results thus suggest that synergistic uptake reactions can be expected to signific

291 ween the species are proposed to explain the synergistic uptake.

292 We propose that the synergistic use of the techniques discussed could prove

293 is however at its infancy to address whether synergistic variability and volatility (major departure

294 druggable candidate whose inhibition creates synergistic vulnerability of PDAC cells to Gem.

295 de promotes T cell tumor infiltration and is synergistic with anti-PD-1 therapy in PDAC mouse models.

296 directly induced ferroptosis and was highly synergistic with erastin.

297 loy closed-loop, nuanced approaches that are synergistic with native physiological processes.

298 a faster rate of RNFL thinning (P < 0.001), synergistic with thinner CCT (P = 0.004) over a mean fol

299 MCT1 inhibition was highly synergistic with vincristine and LDHA inhibition under c

300 utoinflammatory mechanism distinct from, and synergistic with, cytotoxic impairment.