ライフサイエンスコーパス: synergy

1 y) and better than their best member (strong synergy).

2 that the N-deacetylases PdaV and PgdA act in synergy.

3 coverage, and power efficiency, which yield synergy.

4 ng research is framed by Larson's concept of synergy.

5 providing a mechanistic explanation for the synergy.

6 h inhibited the GATA4-NKX2-5 transcriptional synergy.

7 tive binding effect known as catechol-cation synergy.

8 e inhibition of GATA4-NKX2-5 transcriptional synergy.

9 ations below their MIC and thus could act in synergy.

10 olving size, encapsulation, recognition, and synergy.

11 ties, and induce in vitro and in vivo immune synergy.

12 re, we examined the molecular basis for this synergy.

13 e tool kit that can effectively predict drug synergy.

14 orate multiconstituent interactions, such as synergy.

15 ery of factors involved in establishing such synergy.

16 on of the mechanism by which AF(G)Ps achieve synergy.

17 s, but complicates statistical assessment of synergy.

18 imicrobial activities, causing antimicrobial synergy.

19 ntified ATF3 as the driver of this antitumor synergy.

20 . parasanguinis on S. mutans and C. albicans synergy.

21 et independently for each risk factor and in synergy.

22 retained, as expected for nucleation-driven synergy.

23 clear how oral commensals influence pathogen synergy.

24 ion, suggesting a role in PDGFRbeta-Integrin synergy.

25 r cycles and associated with a stable muscle synergy.

26 egree of specificity and a high capacity for synergies.

27 specific synergies coalesce to become merged synergies.

28 ng as well as the potential for programmatic synergies.

29 mporal patterns but all structured in stable synergies.

30 uronal networks that encode locomotor muscle synergies.

31 ion of motor modules representable as muscle synergies.

32 demand fine-tuning or reshaping of the early synergies.

33 a stable association with systematic muscle synergies across movements.

34 unilateral modulation dynamics of the muscle-synergy activations during adaptation, characterized by

35 el to identify combination effects including synergy, additivity and antagonism.

36 ts and multiple functionalities owing to the synergies among multiple components.

37 es are maximized when reserve design fosters synergies among nearby reserves(7,8).

38 tiscale engineering fully exploits the multi-synergy among components to endow the newly designed met

39 TM domains in oligomerization, underscoring synergy among different oligomerization contact regions

40 The synergy among pore volume, guest packing, and linker con

41 ions (RE(3+) = Gd, Eu, Yb, Tm) to achieve a synergy among their magnetic and optical properties and

42 cers than would be identified by traditional synergy analysis.

43 nd the needs of people, to realize potential synergies and avoid conflict between different objective

44 We compare all spatial synergies and their activation/drive strengths as proxie

45 ross divergent food security dimensions, and synergies and trade-offs between sustainable development

46 lternative land-use plans, we identified the synergies and trade-offs between the biodiversity benefi

47 itative elements of targets; and identifying synergies and trade-offs by accounting for interactions

48 tization approach capable of revealing these synergies and trade-offs, incorporating ecological and e

49 Based on synergies and trade-offs, we proposed element optimizati

50 luding grip strength, fine motor skills, and synergies and was frequency band specific.

51 tion data can help determine significance of synergy and antagonism in drug combination screens with

52 is consistent with a modified polymicrobial synergy and dysbiosis model for bacterial involvement in

53 s general photoredox and enzymatic catalysis synergy and enables chemoenzymatic processes for powerfu

54 ppaB signaling is implicated in inflammatory synergy and MDS progression.

55 ypes of HIV-1 that we tested, and shows high synergy and no cross-resistance with approved antiretrov

56 Exploiting this synergy and orthogonality of photolytic and hydrolytic d

57 non-randomly across cortical layers to form synergy and redundancy hubs.

58 erforming as well as their best member (weak synergy) and better than their best member (strong syner

59 During development, synergies are fractionated into units with fewer muscles

60 Recent data have argued that muscle synergies are inborn or determined early in life, but de

61 Predicted synergies are provided and have been validated in gliobl

62 Kinetic data also reveal that synergy arises from differentiated roles for the metals

63 y mixtures can be predicted without positing synergy at the molecular level.

64 ebo-controlled, dose-ranging, phase 2 study (SYNERGY) at 72 sites in 12 countries.

65 highlight potential solutions; and encourage synergies between academia; contract research, developme

66 at lead to progress across multiple SDGs-and synergies between accelerators on achieving SDG-aligned

67 ng broader questions about the potential for synergies between biological and artificial neural netwo

68 s characterizing the Anthropocene, including synergies between biological invasions and climate chang

69 ent of this system, as well as the potential synergies between citizen science, manual biocuration an

70 ithin the motor cortex in the form of muscle synergies between different body parts that compose thes

71 tails of the reaction mechanisms, and strong synergies between ESI-MS defined SAC sites and electroni

72 t reliable, multiplex gene editing to reveal synergies between gene targets remains a major challenge

73 IT97K-499-35 was developed by exploiting the synergies between single-molecule real-time sequencing,

74 Although we find synergies between the conservation of high altitude Poly

75 hness of their structures afford engineering synergies between the metal nodes, functional linkers, e

76 We identify and discuss promising synergies between the studies which look beyond the life

77 and conservation actions and how to promote synergies between them.

78 nzyme by Amphetamine; We also found that the synergies between these two metabolites cause Captagon's

79 We discover new functional synergies between TNF and IFNbeta controlling dendritic

80 te the antibacterial effect of, and possible synergies between, the three main stressors present in h

81 A dual additive approach is used, where the synergy between an alkali metal cation and a polar solve

82 ed as isomers of [H(3)C-Pt-H(CO(2))](-) by a synergy between anion photoelectron spectroscopy and qua

83 ese results reveal a new mechanism of immune synergy between antibodies and T cells and highlights N

84 Moreover, the synergy between Au and Pt metals on the NP surface also

85 P. aeruginosa to AZM and great increases in synergy between AZM and other antimicrobial agents, indi

86 e applied in future food allergy research in synergy between both knowledge institutes and clinicians

87 electrosynthesis is driven by an unexpected synergy between calcium and metaborate.

88 Results highlight the synergy between carbon sequestration and biodiversity co

89 heckerboard susceptibility analysis revealed synergy between ceftazidime-avibactam and fosfomycin.

90 erbright NIR-II contrast agents based on the synergy between chemical synthesis and ultrafast laser p

91 usters 1-5 that are formed by exploiting the synergy between coordinating lanthanides ions as symmetr

92 potential for greater cross-pollination and synergy between corneal and solid organ transplant resea

93 putational model that exploits the potential synergy between deep learning from "big data" (to create

94 s as well as boosted selectivity control and synergy between distinct active sites in multifunctional

95 ate Ca(2+) and CN signaling and demonstrates synergy between experimental and computational methods,

96 e aim of this review is to underline how the synergy between far-IR spectroscopy and theory can provi

97 However, the synergy between Fe(0) abiotic reactions and microbiologi

98 Recently, adhesive synergy between flanking lysine (Lys, K) and 3,4-Dihydro

99 Here, based on the well-established synergy between histone deacetylase inhibitors (HDACi) a

100 ther, this work highlights the importance of synergy between host defenses and the necessity of evalu

101 d provide biological rationale for potential synergy between ibrutinib and venetoclax.

102 Finally, synergy between IL-15 and IL-21 was observed only upon C

103 the basic dynamic mechanisms underlying the synergy between immunotherapy and epigenetic therapies a

104 servations and animal models have long shown synergy between influenza virus infections and bacterial

105 Synergy between inhibitors of matrix metalloproteases an

106 The demonstration of intramolecular synergy between LPMOs and hydrolytic enzymes reported he

107 rch, Xie and colleagues reveal an unexpected synergy between MEK inhibitors and immune checkpoint blo

108 ese two mutations and demonstrate a striking synergy between Mir142 loss-of-function and IDH2(R140Q),

109 the pathophysiology of LHON arising from the synergy between mitochondrial ND1 and ND4 mutations.

110 This synergy between mutations in components of the RDR6-SGS3

111 tion, raising the possibility of therapeutic synergy between NA inhibitors and anti-stem mAb treatmen

112 tron energies ~1 keV, due to an undocumented synergy between neighbouring metal and dielectric domain

113 In particular, via a synergy between NMR and kinetic experiments, we demonstr

114 al level, could shed light on the intriguing synergy between non-Hermiticity and supersymmetry.

115 Collectively, these results highlight the synergy between ONECUT2 and hypoxia in driving NEPC, and

116 Epidemiological synergy between outbreaks of viruses transmitted by Aede

117 The Synergy between PCI with Taxus and Cardiac Surgery (SYNT

118 posite endpoints at 5 years in the SYNTAXES (Synergy between PCI with Taxus and Cardiac Surgery Exten

119 (Synergy Between PCI With TAXUS and Cardiac Surgery: SYNT

120 (Synergy Between PCI With TAXUS and Cardiac Surgery: SYNT

121 mice subjected to PD-1 blockade, indicating synergy between PD-1 blockade and Siah2 loss.

122 The close synergy between peptides and nucleic acids in current bi

123 In the SYNTAX (Synergy Between Percutaneous Coronary Intervention With

124 The SYNTAX (Synergy Between Percutaneous Coronary Intervention With

125 Synergy between PMBN and EPIs boosted azithromycin activ

126 Our results reveal how synergy between profilin and formins generates robust fi

127 We show how synergy between properly placed acceptor and donor group

128 The integration and synergy between proteins and nanomaterials for biosensin

129 In this manuscript, we investigate synergy between PS and phosphatidylethanolamine (PE)-a l

130 of severe PH that provides insight into the synergy between pulmonary vascular injury and diminished

131 ngful clinical outcomes - if such a clinical synergy between radiation and ICI does exist - before th

132 se to radiotherapy and suggest a therapeutic synergy between radiotherapy and immune checkpoint inhib

133 ose that peptide binding is co-determined by synergy between the binding pockets of the MHC molecule.

134 Synergy between the inhibitory effect of progesterone an

135 ighted MB-PLS1-DA models benefiting from the synergy between the two sources of data were more discri

136 and without much attention to the potential synergy between these functional traits.

137 roviding an additional temporal mechanism of synergy between these Gq- and Gi-coupled GPCRs.

138 The rich opportunity offered by the synergy between these two classes of materials, however,

139 level data fusion, taking advantage from the synergy between these two data sets.

140 The concept of synergy between two agents, over a century old, is impor

141 ncreased nucleation is a critical element of synergy both in vitro and in vivo.

142 Our study demonstrates a synergy by using WGS for diagnosis and aetiological disc

143 This synergy caused membrane depolarization, destruction of t

144 We seek to understand how locomotor synergies change during development and training by stud

145 llected and analyzed to determine how muscle synergies change in response to perturbations.

146 0.43) while AZD2014 and afatanib also showed synergy (CI(50) = 0.41) against a chordoma cell in vitro

147 As adults train to run, specific synergies coalesce to become merged synergies.

148 Mechanistic understanding of this synergy could lead to the development of macromolecular

149 ines and cis-(+)-12-oxophytodienoic acid, in synergy, could act as anticancer compounds.

150 The synergy depends on the presence of the active promoter/o

151 The synergy derived from the model is found to be in agreeme

152 oid proximity is <500 nm, but this signaling synergy diminishes upon receptor segregation beyond this

153 in strong contrast to previous reports that synergy dominates yet supportive of more recent studies

154 ar patterns of muscle activations and muscle synergies during forward and backward locomotion are con

155 The mechanism of this synergy effect has remained obscure and is addressed her

156 Identifying those synergies ex ante facilitates the harmonization of polic

157 earchers in analyzing and planning their own synergy experiments.

158 ing development and training by studying the synergies for running in preschoolers and diverse adults

159 taging and tumor biology yields a predictive synergy for determining breast cancer prognosis.

160 ients), prediction of drug response and drug synergy for individual tumors (treatment prioritization

161 This collective model shows increased synergy for regimens where trastuzumab is administered p

162 dy demonstrated, for the first time, a N-E-W synergy for resource-efficient wastewater treatment usin

163 orphology patterns allows us to predict drug synergies; for example, certain beta-lactams appear to w

164 ependent component analysis (ICA) to extract synergies from electromyography (EMG).

165 lerate, no consensus on how to quantify drug synergy has emerged.

166 development of a mathematical model of drug synergy has potential to evaluate and improve standard-o

167 Homogeneous sub-populations comprising synergy hubs decode stimulus information significantly b

168 There were strong force-stabilizing synergies in the MU-mode space during accurate cyclical

169 kemia mouse-models, resulting in therapeutic synergy in 75% of the tested models.

170 s disrupts S. mutans and C. albicans biofilm synergy in a contact and H(2)O(2)-independent manner.

171 AZM also demonstrated increased synergy in combination with synthetic host-defense pepti

172 2 expression, they nevertheless demonstrated synergy in doing so, likely attributable to their differ

173 Realizing improved strength-ductility synergy in eutectic alloys acting as in situ composite m

174 peron might explain increased AZM uptake and synergy in host-like media.

175 ockout of Dll4 and Fgf8 demonstrates genetic synergy in OFT alignment.

176 DK4/6 inhibitors, respectively) demonstrated synergy in vitro (CI(50) = 0.43) while AZD2014 and afata

177 Polepsilon proofreading defects produces no synergy, indicating that Polepsilon cannot correct error

178 Electrochemically, a unique synergy is achieved that is driven by interfacial tensio

179 e actin assembly, but the mechanism of their synergy is controversial.

180 This demonstrates that synergy is effective in promoting coagulation factor bin

181 Instead, this lifespan-extending synergy is exclusively dependent on the lysosome biogene

182 The mechanistic basis of the observed synergy is likely enhanced inhibition of CD4 binding to

183 presence of glucose-6 phosphate, significant synergy is observed.

184 Synergy is predicted with an accuracy matching biologica

185 This synergy is proposed to be driven by elongation and the f

186 The synergy is rationalized by the ability of the quinazolin

187 The catalytic synergy is responsible for reduction of the oxidation te

188 standard photovoltaic technologies, a proper synergy is still lacking between the recently growing 2D

189 Predicted synergy is supported by disease-specific and clinically

190 Fractionation and merging of muscle synergies may be a mechanism for modifying early motor m

191 s transcriptional cascade suggests that drug synergy may ensue when the transcriptional responses eli

192 FTIR analysis additionally suggested that a synergy may exist solely in the triply doped system, whe

193 The different synergy mechanism of gamma-terpinene with mono- and poly

194 infer the combinatorial drug efficacies and synergy mechanisms through drug functional module-induce

195 Presences of specific synergy-merging patterns correlate with enhanced or redu

196 was confirmed by HSA (Highest Single Agent) synergy model.

197 rding the appropriate domains of conflicting synergy models - fissures impacting all aspects of combi

198 understanding is frequently lacking for the synergy observed when combining deacetylase and bromodom

199 Remarkably, we find that spatial primitives/synergies of adult injured and neonatal injured rats dif

200 ositive associations, suggesting accelerator synergies of combination provisions.

201 Synergies of experiments and computations demonstrate th

202 y laser vaporization, and characterized by a synergy of anion photoelectron spectroscopy and electron

203 Along with minimal invasiveness, the synergy of both enzymes was very useful to increase the

204 eves such chemoselectivity via an unexpected synergy of catalyst design and acid additive.

205 The resulting synergy of complementary effects of Au core and surface

206 The synergy of favorable band energy alignment and concerted

207 The synergy of Fe and Cu atoms in such confined subnano spac

208 Our results demonstrated that the synergy of H(2)O(2) and gluconic acid is essential for t

209 imisation and a clear path towards increased synergy of machine learning and quantum chemistry.

210 he two-stage cracking process induced by the synergy of micro-voids and nano-voids.

211 metastases in mice and the immunotherapeutic synergy of protein arginine deiminase 4 (PAD4) inhibitor

212 phages in their natural context, and how the synergy of simple phage macromolecules brings about comp

213 king order in live mammalian cells through a synergy of single-molecule and super-resolution methods.

214 alidated resistance delay and thus long-term synergy of targeted therapeutics in advanced melanoma mo

215 Conclusion: The synergy of TGF-beta and Axl induces CXCL5 secretion, cau

216 We show the functional synergy of the dual-agonist cargo can be tweaked by adju

217 d the high nonlinearity could arise from the synergy of the mid-gap traps assisted electronic transit

218 response sigma factor mutants confirmed the synergy of the three stressors, which is enhanced at hig

219 erall, our analysis underscores the powerful synergy offered by combining molecular orbital and VB th

220 i(OH)(2)-GR is attributed to its appropriate synergy on the enhanced adsorption of CO(2), increased a

221 th young and adult animals, comprising motor synergies or primitives.

222 develop a robust method for determination of synergy or additivity in antibody combinations.

223 e mixed inhibitor treatment modes, we tested synergy or antagonism between several inhibitors with tu

224 te abundant expression of ZAP, indicative of synergy or complementation of these hitherto unconnected

225 mise that spinal circuit modules for spatial synergy patterns may be determined early, before postnat

226 Exploiting the amino-catechol synergy, polymeric pressure-sensitive adhesives (PSAs) h

227 This rare insight into intermetallic synergy rationalizes the outstanding catalytic performan

228 Synergy refers to performance gains that are attributabl

229 s of repeated kicking, on the one hand, with synergies resulting from fractionation of those revealed

230 Rather, surveying the landscape of drug synergy reveals the persistence of historical fissures r

231 erformed a focused flow cytometry-based drug synergy screen and identified a novel synergistic intera

232 dult spinal cords rapidly converge to common synergy sets.

233 mode space confirmed the existence of strong synergies stabilizing finger force.

234 There were no synergies stabilizing MU-mode magnitude in the space of

235 the exo70A1 vamp721 mutant showed a strong, synergy, suppressing growth and cell expansion beyond th

236 Antimicrobial synergy testing and therapeutic drug monitoring assessed

237 Overall, studies reported more synergies than trade-offs between reduced climate impact

238 However, intact rats possess some synergies that differ significantly, although modestly,

239 We also introduce a typology of 5 classes of synergies that enables an understanding of their causal

240 nts not just muscles of the body, but muscle synergies that form the building blocks of the complex b

241 Indeed, we identified five muscle synergies that were similar during forward and backward

242 e of these three biologic inhibitors creates synergy that offers a series of advantages to the molecu

243 fying short- and long-term drug kinetics and synergies to identify the most effective drug combinatio

244 e argue that this will achieve the necessary synergy to accelerate progress in the discovery and appl

245 For synergy to occur, an active isoform first binds to the f

246 nd schistosome-specific CD8 T cells acted in synergy to reduce HBV-induced pathology during the TH1 p

247 t Cu and Fe in the binary system can work in synergy to significantly deform the linear configuration

248 cer and uncover potential mechanisms of drug synergy, warranting further studies in individual cancer

249 This fin-body synergy was absent in vestibular mutants, suggesting sen

250 Synergy was also observed against breast cancer stem cel

251 This synergy was dependent on TAA cross presentation to cytol

252 While in vitro synergy was modest, cefazolin plus ertapenem exhibited s

253 Anti-oxidative synergy was not seen in any of the tested lycopene-antho

254 No such synergy was observed for cells treated with alpha-TOH.

255 Using two distinct measures of pharmacologic synergy, we demonstrated that SOS1 inhibition strongly s

256 To elucidate the molecular mechanism of this synergy, we investigated the effects of the two drugs, i

257 erns of muscle activations, including muscle synergies, were similar for forward and backward locomot

258 al antibiotics, highlighting their potential synergies when used in combination.

259 fat pad of syngeneic mice, and demonstrated synergy when combined with anti-PD-1 therapy.

260 ractions downstream of mutated EGFR revealed synergy when combining an EGFR-TKI with inhibitors of pr

261 in challenging and are biased to identifying synergies which are prioritized in conservation.

262 bilayer leads to innate and adaptive immune synergy which biases a Th1 immune response.

263 for studying diet patterns assume no dietary synergy, which can lead to bias if incorrectly modeled.

264 and logistic regression suggest that dietary synergy, which is accounted for in machine learning, may

265 small number of interventions show positive synergies with both SDGs and NCPs with no significant ad

266 e need for further theoretical innovation or synergies with other kinds of psychological or structura

267 to increase its social impact and to develop synergies with some currently more distant disciplines t

268 positive PCa xenograft models and can act in synergy with a potent AR antagonist, enzalutamide.

269 rkably, ELFN2 in cone terminals functions in synergy with a related adhesion molecule, ELFN1, and the

270 3K and EGFR combination therapies, observing synergy with alpha isoform-selective PI3K inhibitor HS-1

271 could be useful therapeutically, possibly in synergy with an antibody that blocks receptor attachment

272 ecreased prostate cancer growth alone and in synergy with androgen-receptor antagonist treatment in v

273 genetic drugs as another mechanism for their synergy with anti-PD-1.

274 nd binding increases nucleation by Spire and synergy with Cappuccino in bulk pyrene assays and on bea

275 oal to establish the mechanism for potential synergy with cisplatin.

276 the novel nonblocker anti-PD-1 Abs and their synergy with classical blocker Abs may be instrumental i

277 ogical and anthropogenic variables acting in synergy with climate change.

278 Moreover, copB displayed genetic synergy with copA, suggesting that CopB functions in Cu

279 41 compounds showed strong synergy with DNAJA1 loss, whereas 18 dramatically lost p

280 ry immune responses and after vaccination by synergy with effector T cells and virus-specific antibod

281 Dasatinib exhibited synergy with everolimus in the treatment of HGG cells at

282 TGFBR1 inhibitors show synergy with existing therapeutics in treating GATA4-def

283 tins for cytotoxic effect, anti-TB activity, synergy with first-line drugs in macrophages, pharmacoki

284 ximize the immunomodulating effect of IRE in synergy with follow-up immunotherapy.

285 ic, "hot" tumor microenvironment, working in synergy with immunotherapies to increase patient respons

286 ize radiotherapy regimens and maximize their synergy with immunotherapy.

287 ineffective as monotherapy but demonstrates synergy with inhibitors of JAK/STAT signaling, doubling

288 f the extension of DR1 provides a remarkable synergy with LDTFs.

289 io is predictive of ERK1/2 pathway inhibitor synergy with MCL1 or BCL2/BCL-w/BCL-X(L) inhibitors.

290 limus-induced phosphorylated SMAD1/5 acts in synergy with metabolic stress-activated FOXO1 through fo

291 structure of the surface Fe sites, and their synergy with nearest-neighbor M sites through formation

292 ne-associated serine proteinases (MASPs), in synergy with or in place of TMPRSS2, contribute to activ

293 Such habitat loss acts in synergy with other important threats (e.g., logging and

294 anism of action may be critical for enhanced synergy with PI3K inhibitors in HNSCC patients and motiv

295 We observed synergy with regulators of cell cycle progression, YAP,

296 ential cofactor in this process and works in synergy with SDHAF2 to properly orient the flavin and ca

297 A low dose of THZ1 displayed potent synergy with the HER2 inhibitor lapatinib in HER2iR BC c

298 Infigratinib acts in synergy with the microtubule-depolymerizing drug vinorel

299 Present shortcomings may turn into areas of synergy with the potential to link neuroscience educatio

300 cade and sought to dissect its role, also in synergy with thymic stromal lymphopoietin (TSLP), in air