ライフサイエンスコーパス: synonymous mutation

1 ange at the protein level (i.e. 'silent' or 'synonymous' mutations).

2 orders of magnitude greater than the rate of synonymous mutation.

3 se mutations were found, as well as a linked synonymous mutation.

4 g of all MAP2K7 exons did not reveal any non-synonymous mutations.

5 engineered capsid sequences with hundreds of synonymous mutations.

6 onymous rates reflect purifying selection on synonymous mutations.

7 tional tendencies and complete neutrality of synonymous mutations.

8 ntified and revealed both synonymous and non-synonymous mutations.

9 cing different patterns on nonsynonymous and synonymous mutations.

10 e distribution and ages of nonsynonymous and synonymous mutations.

11 ion, one chain-termination mutant, and three synonymous mutations.

12 there is nonetheless selection in humans on synonymous mutations.

13 ls pervasive weak negative selection against synonymous mutations.

14 were in coding regions, and 12 presented non-synonymous mutations.

15 S), the normalized ratio of nonsynonymous to synonymous mutations.

16 measured changes in specific activity due to synonymous mutations.

17 -synonymous mutations in an investigation of synonymous mutations.

18 ed a constrained evolutionary path, even for synonymous mutations.

19 e T dimerization, however, is insensitive to synonymous mutations.

20 always adequate to substantiate selection on synonymous mutations.

21 ations as well as between synonymous and non-synonymous mutations.

22 trees branches following synonymous and non-synonymous mutations.

23 We observe three nonsynonymous and two synonymous mutations.

24 diverse methods to understand the effects of synonymous mutations.

25 by an almost complete lack of noncoding and synonymous mutations.

26 ake functional predictions possible even for synonymous mutations.

27 thods, its performance is not limited to non-synonymous mutations.

28 generated 24 different nonsynonymous and 13 synonymous mutations.

29 s (1.15), and the ratio of non-synonymous to synonymous mutations (1.18) was less than half of that e

30 oma and these tumours contain only 30-50 non-synonymous mutations(5).

31 n, we found that potentially deleterious non-synonymous mutations (9566 SNPs) explained as much genet

32 Moreover, the ratio of nonsynonymous to synonymous mutations, a measure of positive selection pr

33 aring the accumulation of synonymous and non-synonymous mutations across pairs of globally sampled ge

34 library in SMN1 exon 7, we show that 23% of synonymous mutations across the exon decrease exon inclu

35 several estimates of selection intensity on synonymous mutations all suggest a detectable influence

36 hIP) variants, we recently discovered 18 non-synonymous mutations, all with frequencies less than 2%

37 me and supported by a neutral clock based on synonymous mutations alone.

38 We find synonymous mutations alter oligoribonuclease's dimer pro

39 tions identified were biallelic and included synonymous mutations altering splicing of physiological

40 A novel heterozygous non-synonymous mutation and a novel polymorphism in OMI/HTRA

41 e regions had higher ratios of nonsynonymous/synonymous mutations and encompassed immunodominant epit

42 election coefficient (s) against unpreferred synonymous mutations and found the value (s >or= 10(-5))

43 , especially those arising from selection on synonymous mutations and from the choice of genes, are d

44 y of 1.9 x 10(7) with over 8500 possible non-synonymous mutations and inferred the effects of each mu

45 Our data suggest that non-synonymous mutations and mutations that increase the len

46 sceptibility testing, after the exclusion of synonymous mutations and nonsynonymous mutations previou

47 ess accumulated lethal mutations, excess non-synonymous mutations, and excess transposable element in

48 es differed by one or two reverse engineered synonymous mutations, and measured the transmission of t

49 her mammalian PB2 adaptation (Q591K, n = 6), synonymous mutations, and minor variants.

50 tory events include nonsynonymous mutations, synonymous mutations, and mutations at splice sites.

51 terogeneity or lower ratios of nonsynonymous/synonymous mutations, and none except one of these regio

52 n protein and numerous spliced variants, non-synonymous mutations, and post-translational modificatio

53 Synonymous mutations are coding mutations that do not al

54 More non-synonymous mutations are found in PAVs than core genes,

55 hypothesis is that selection coefficients on synonymous mutations are inversely related to the total

56 s of codon bias in Drosophila indicates that synonymous mutations are not neutral, but rather are sub

57 Missense or non-synonymous mutations are nucleotide substitutions that a

58 However, synonymous mutations are rarely investigated in the canc

59 variable effects model, we infer that 11% of synonymous mutations are subject to strong purifying sel

60 more, aside from those that affect splicing, synonymous mutations are typically ignored as potential

61 onymous to synonymous mutations; however, if synonymous mutations are under purifying selection, this

62 how conserving, or radically different, non-synonymous mutations are with respect to some key amino

63 occurring mutations, both nonsynonymous and synonymous mutations, as well as mutation combinations i

64 ur study identified an independent risk of a synonymous mutation at HLA-DOA, a non-classical HLA gene

65 Evolving neoplasms accumulate non-synonymous mutations at a high rate, potentially enablin

66 Furthermore, we found a trend of increased synonymous mutations at the sites for more efficient A3A

67 s) of non-synonymous mutations relative to a synonymous mutation background.

68 ancer-associated genes that are enriched for synonymous mutations based on a non-coding background mo

69 for estimating the intensity of selection on synonymous mutations based on the frequencies of unprefe

70 e sequence analysis revealed a number of non-synonymous mutations between copies of the kinetochore g

71 Low non-synonymous mutation burden and programmed death-ligand 1

72 L deficiency due to homozygosity for a novel synonymous mutation (c.222C->A, p.V74V).

73 variant under selection in Europeans (a non-synonymous mutation, C282Y) has been relatively well-stu

74 Although some synonymous mutations can affect RNA splicing, translatio

75 formation specific and provide evidence that synonymous mutations can alter the drug sensitivity of p

76 However, synonymous mutations can change mRNA structures in ways

77 7T/1101A, demonstrating that combinations of synonymous mutations can have functional consequences dr

78 However, recent studies suggest that synonymous mutations can influence nearly every step in

79 dynamics, and dimerization to understand how synonymous mutations can influence the dimerization of t

80 Both common genetic variants and rare non-synonymous mutations can interact to increase SLE risk.

81 Assuming all non-synonymous mutations cause resistance, we report 90% sen

82 hanges in codon translation rates induced by synonymous mutations cause shifts in co-translational an

83 Synonymous mutations change the DNA sequence of a gene w

84 ions, we found that de novo near-splice site synonymous mutations changing exonic splicing regulators

85 anisms are now thought to cause selection on synonymous mutations, commonly supported by a low evolut

86 n, uncatalogued bla(TEM-1) alleles with only synonymous mutations compared with the known reference w

87 bases) of 200 other GPCRs, with recorded non-synonymous mutations, confirmed a high frequency of Arg-

88 er 260 000 somatic alterations including non-synonymous mutations, copy number variants and structura

89 study in yeast, there have been claims that synonymous mutations could be as important as nonsynonym

90 Molecular modeling predicts that these non-synonymous mutations could disrupt NADPHO complex assemb

91 ed exonic definition of exon 4 and the MMP20 synonymous mutation decreased exonic definition of exon

92 py and hindering their fixations relative to synonymous mutations despite continued population adapta

93 Amongst the 18 non-synonymous mutations detected, was N485I, in the ace-1 g

94 er of other single-sample reports of IDH non-synonymous mutation, did not elevate cellular 2HG levels

95 This effect implies that synonymous mutations disrupting mRNA secondary structure

96 e Atlas using the ratio of non-synonymous to synonymous mutations (dN/dS) and find 85 driver genes, i

97 The ratio of non-synonymous to synonymous mutations (dN/dS) has become a popular method

98 Synonymous mutations do not alter amino acids and are ge

99 Synonymous mutations do not alter the encoded protein, b

100 ting between neutral and disease-causing non-synonymous mutations documented in the human population

101 sults, and augmenting out-of-frame data with synonymous mutations does not aid out-of-sample performa

102 ut detectable signature of weak selection on synonymous mutations during mammalian evolution, likely

103 hypothesis that the mean age of segregating synonymous mutations equals the mean age of segregating

104 are consistent with purging of recessive non-synonymous mutations exposed to selection in founder-ass

105 We systematically analyzed ~10(6) non-synonymous mutations extracted from COSMIC, involving ~8

106 Notably, we found one non-synonymous mutation (fimA-Mut.6) across all Salmonella s

107 lternative RNA splicing effect as a reported synonymous mutation for Crouzon syndrome.

108 te the distribution of fitness effects among synonymous mutations for a gene under directional select

109 full-genome sequences, we estimate rates of synonymous mutations for each mutation type and examine

110 s of the functionality and non-neutrality of synonymous mutations for various analyses and conclusion

111 haracterize the functional properties of non-synonymous mutations found in ORF-1 a/b, S, and N genes.

112 It is conceivable that non-synonymous mutations found in tumor mitochondrial DNA (m

113 of the additional mutation PB2 628R and/or a synonymous mutation from an A to a G nucleotide at nucle

114 yze the variant allele frequency spectrum of synonymous mutations from healthy blood and esophagus to

115 ymorphisms, there is a significant excess of synonymous mutations from preferred to unpreferred codon

116 18-20, we detected five different single non-synonymous mutations: Glu605Lys, Arg622Ile, Asn657Lys, L

117 Synonymous mutations had highly variable fitness effects

118 Synonymous mutations have been shown to alter gene expre

119 to have little to no functional consequence, synonymous mutations have been widely used in evolutiona

120 Several mouse models harboring synonymous mutations have shown alterations in synaptic

121 sites with high ratios of non-synonymous to synonymous mutations; however, if synonymous mutations a

122 We analyze de novo synonymous mutations identified in autism spectrum disor

123 een linked to epithelial malignancy with non-synonymous mutations identified in both MTG8 and MTG16 i

124 The strong non-neutrality of most synonymous mutations, if it holds true for other genes a

125 RNA sequence optimization of Cas9 by synonymous mutation improves its safety.

126 We identified a synonymous mutation in affected individuals that alters

127 fic immune response against the virus; a non-synonymous mutation in an epitope region of the virus is

128 eport shows selection of a recurrent somatic synonymous mutation in cancer.

129 onal cloning revealed that zl1 carries a non-synonymous mutation in GRMZM2G141636, which encodes a pu

130 determining the fruit shape, including a non-synonymous mutation in the gene Longifolia 1-like (CA03g

131 Another synonymous mutation in the same exon, c.321C>T (p.D107D)

132 This identified 52 somatic non-synonymous mutations in 32 genes, many of which were nov

133 sing temperature, a CPD RSV containing 2,692 synonymous mutations in 9 of 11 ORFs did not lose temper

134 Nonsynonymous and synonymous mutations in a PEST-like domain near the LLO

135 ~10(-7) per site per generation; considering synonymous mutations in a sample of 390,000 individuals,

136 Furthermore, we found non-synonymous mutations in a set of plausible candidate gen

137 The non-synonymous mutations in AgNP-treated populations were mo

138 Significant excess of non-synonymous mutations in AKAP4 (p<0.02), a gene mediating

139 This selection pressure against synonymous mutations in alternatively spliced exons was

140 ierarchy is reflected in the fitness cost of synonymous mutations in amino acid biosynthesis genes an

141 oal is to adopt the current standard for non-synonymous mutations in an investigation of synonymous m

142 We discovered non-synonymous mutations in ARID1A, FBXW7, PIGR, ZC3H12A, an

143 These data suggest that non-synonymous mutations in ASB10 do not cause Mendelian for

144 The synonymous mutations in BCL2 are enriched in its anti-ap

145 m future experimental studies on the role of synonymous mutations in cancer biology.

146 nza PR8 viruses containing codon-deoptimized synonymous mutations in coding regions comprising the en

147 Given the role of synonymous mutations in disease and drug codon optimizat

148 ry of over 50,000 edits that consist of only synonymous mutations in Escherichia coli.

149 of the pre-mRNA as well as 29 variants with synonymous mutations in exon 12.

150 he patterns and rates of the accumulation of synonymous mutations in isolates collected from the pati

151 s of evidence suggest that selection acts on synonymous mutations in mammals.

152 Synonymous mutations in messenger RNAs (mRNAs) can reduc

153 D8A mutant viruses selected second-site non-synonymous mutations in nsp14 associated with improved m

154 sociated with faster clade growth rates than synonymous mutations in ORF8.

155 ide resistance alleles in OsALS and creating synonymous mutations in OsSPL14 to resist OsMIR156-media

156 Synonymous mutations in protein-coding genes do not alte

157 All non-synonymous mutations in reactive T cell epitopes were te

158 Synonymous mutations in Rv3792 increased the expression

159 We identify Asian-derived non-synonymous mutations in the AHR gene that associate with

160 ation at the p110 start codon, we introduced synonymous mutations in the coding region between the p1

161 vious study identified 3 nonsynonymous and 6 synonymous mutations in the entire mosquito sodium chann

162 In two OS cases, we found de novo non-synonymous mutations in the genes KCNQ2 and SCN2A.

163 We report here that some synonymous mutations in the human DRD2 have functional e

164 heterogeneity, the ratio of nonsynonymous to synonymous mutations in the immunopeptidome (immune dN/d

165 immune dN/dS, the ratio of nonsynonymous to synonymous mutations in the immunopeptidome, to measure

166 lex species, we identified a total of 15 non-synonymous mutations in the insecticide target genes, in

167 ic analysis revealed the existence of higher synonymous mutations in the intronless divergents of ReC

168 Resistance Network on the prevalence of non-synonymous mutations in the Kelch 13 (K13) gene, which a

169 Introduction of synonymous mutations in the minigenome RNAs also affecte

170 Analysis of both 5' UTR and synonymous mutations in the PEST-like domain that are pr

171 Non-synonymous mutations in the SARS-CoV-2 spike region affe

172 g the co-existence of both nonsynonymous and synonymous mutations in the sodium channel of resistant

173 10 non-synonymous mutations in the spike protein gene were at p

174 e, showing parallel frequency changes in non-synonymous mutations in the three studied populations.

175 Two additional non-synonymous mutations in this gene exhibit similar phenot

176 Mutated proteins derived from non-synonymous mutations in tumor genomic DNA are the major

177 In this study we identified deleterious non-synonymous mutations in two cilia genes, Dnah11 and Mks1

178 In addition, non-synonymous mutations in two MAPK (mitogen-activated prot

179 ints, contributing also to the evidence that synonymous mutations in viral ssRNA genomes are not stri

180 locus is deleted in PA80 alongside a few non-synonymous mutations in virulence factors including prot

181 dentified within the groups, only three were synonymous mutations, indicating strong positive selecti

182 Such allelic disparity is observed for some synonymous mutations, indicating they may not be biologi

183 t the bioinformatics analysis, we introduced synonymous mutations into conserved codons within known

184 oach, we introduce a barcoded library of non-synonymous mutations into hotspot codons 12 and 13 of Kr

185 Introduction of 54 synonymous mutations into the insert had no detectable e

186 in levels and for understanding selection on synonymous mutations, it would be valuable to computatio

187 liced exons and a decrease in the density of synonymous mutations (Ks).

188 We identified two non-synonymous mutations (L50F and R188G) in Mpro encoded by

189 outheast Asia there is a great excess of non-synonymous mutations, many of which cause radical amino-

190 that changes in protein expression caused by synonymous mutations may be most important when an organ

191 tropism, and immune evasion, while frequent synonymous mutations may modify viral fitness.

192 sembly checkpoint function and suggests that synonymous mutations may weaken the checkpoint.

193 The possibility that synonymous mutations might be enriched in cancer has bee

194 10 unique clones that differ by two or three synonymous mutations (molecular tags).

195 Our results reveal that synonymous mutations most likely play an underappreciate

196 uencing approach, we demonstrated that a non-synonymous mutation, MT-CO1 (V274I), could be detected i

197 ata indicate that selection coefficients for synonymous mutations must vary by a minimum of one or tw

198 reduced cAMP production arising from the non-synonymous mutations (n = 23) with patients with non-syn

199 the vaccine and its parent, as well as five synonymous mutations, none of which involves cis-acting

200 The fitness effects of synonymous mutations, nucleotide changes that do not alt

201 Only synonymous mutations occurred in Pfk13.

202 t CUG codons within the +1 reading frame: 1) synonymous mutation of CUG codons in the M2-reading fram

203 A non-synonymous mutation of human SLC25A45 (R285C) stabilizes

204 The non-synonymous mutation of the H5 hemagglutinin (HA) gene ha

205 Synonymous mutations, once known as "silent" mutations,

206 Inactivating m(6)A addition sites with synonymous mutations or demethylase resulted in m(6)A-de

207 bacterial behaviour are associated with non-synonymous mutations or insertion-deletions in defined r

208 Synonymous mutations or protein expression losses in ACT

209 We identified non-synonymous mutation (p.Glu38del) in MAP3K9 in ten tumors

210 individual variability driven largely by non-synonymous mutations, particularly in the N-terminal and

211 crepancies indicate that, in contrast to the synonymous mutations, parts of STEC O157 genomes have ev

212 The average mutation burden is 95 non-synonymous mutations per area, exceeding previous CCA in

213 noncoding mutations or a difference between synonymous mutations potentially advantageous or deleter

214 included the number of tumor-associated non-synonymous mutations, predicted neo-antigen load and PD-

215 th likely functional effects, as well as non-synonymous mutations predominantly in MDR-/XDR-TB strain

216 the timing of the action of selection on non-synonymous mutations predominantly to the Holocene.

217 impacted by mutations, with three recurrent synonymous mutations present in multiple SARS-CoV-2 line

218 Neoantigens are peptides derived from non-synonymous mutations presented by human leukocyte antige

219 M model-on out-of-frame sequence data and on synonymous mutations-produce significantly different res

220 Synonymous mutation progressively optimized human codons

221 Non-synonymous mutations purged in modern Norwegian killer w

222 two rare potentially disease-associated non-synonymous mutations, Q170H and R181G, in the ADAM10 pro

223 coded by genes that have a non-synonymous to synonymous mutation rate even greater than immune-relate

224 the rate of mutation, such that the average synonymous mutation rate is 20-30% higher than in noncod

225 ining 40 genome pairs, we estimated that the synonymous mutation rate was 1.38 x 10(-5) per site per

226 Accordingly, the synonymous mutation rate was consistently greater than t

227 ighly structured, conserved, and contain low synonymous mutation rates.

228 ons are detected using the synonymous to non-synonymous mutations ratio.

229 al excess calculated using non-synonymous to synonymous mutation ratios (dN/dS).

230 and non-coding regions and synonymous-to-non-synonymous mutation ratios suggest the neutral drift bei

231 ores of observed/expected synonymous and non-synonymous mutation ratios.

232 hypothesis proposes that interference among synonymous mutations reduces the efficacy of selection o

233 RNA variant allele frequencies (VAFs) of non-synonymous mutations relative to a synonymous mutation b

234 rS, ttrB, ttrC, and ttrA (7, 2, 2, and 7 non-synonymous mutations, respectively).

235 Three-quarters of synonymous mutations resulted in a significant reduction

236 ructures associated with vPAR-CL sites using synonymous mutations, resulting in varied effects to vir

237 contiguous subsegment mutant viruses having synonymous mutations revealed that subsegments SS8195-82

238 Analysis of synonymous mutations showed the same pattern.

239 However, a CPD RSV containing 1,378 synonymous mutations solely in the polymerase L ORF quic

240 reover, we show that, despite only a few non-synonymous mutations specifically targeting arginine res

241 Synonymous mutations, such as I507-ATC-->ATT, in deletio

242 significantly lower than the average age of synonymous mutations, suggesting the presence of slightl

243 le admixture, have accumulated many more non-synonymous mutations than African strains.

244 ccumulate more transposable elements and non-synonymous mutations than other genes during individual

245 es have accumulated proportionally fewer non-synonymous mutations than other populations.

246 ates, whereas ttrR was more conserved (0 non-synonymous mutations) than ttrS, ttrB, ttrC, and ttrA (7

247 Several synonymous mutations that abolish secretion of hybrid pr

248 nted for by localised purifying selection on synonymous mutations that affect splicing.

249 be altered over long timescales in cells by synonymous mutations that alter a messenger RNA molecule

250 es, and weak selection influence the fate of synonymous mutations that are present today as polymorph

251 cular, plays any role in shaping the fate of synonymous mutations that are present today in human pop

252 Also, multiple synonymous mutations that changed the mRNA sequence of y

253 on may show a relatively large number of non-synonymous mutations that conserve a particular property

254 gene on de novo tumorigenesis, we introduced synonymous mutations that converted rare codons into com

255 ns targeted to 1,149 essential genes and for synonymous mutations that disrupted splice site motifs a

256 us mutations (n = 23) with patients with non-synonymous mutations that had no reduction in cAMP (n =

257 by examining patterns of synonymous and non-synonymous mutations that have accumulated in SARS-CoV-2

258 nes, illustrating the positions of these non-synonymous mutations that mainly located on the a-helix

259 lus (mRNA) and minus (vRNA) strands and used synonymous mutations to ablate m(6)A on both strands of

260 The estimated contribution of these synonymous mutations to disease liability is comparable

261 f the BC supergene and dragging multiple non-synonymous mutations to high frequency.

262 n we measure the effect of four adaptive non-synonymous mutations to the glycerol kinase (glpK) gene

263 ssessed the influence on the response of non-synonymous mutations (tumor mutational burden or TMB), c

264 pattern of differences in synonymous and non-synonymous mutations, under the assumption of neutrality

265 000 years old, to identify fixed derived non-synonymous mutations unique to the species and to obtain

266 ancer-associated genes that are enriched for synonymous mutations using whole genome sequencing data.

267 ulting in either the S639F substitution or a synonymous mutation was introduced in an echinocandin-su

268 1 to 10, generated by a combination of nine synonymous mutations, was defective in secretion signali

269 packaging signals were inactivated by serial synonymous mutations, was flanked by the NA segment-spec

270 orrection mechanisms and the consequences of synonymous mutations, we analyzed the effect of mechanis

271 ipoprotein A-V (APOA5), carriers of rare non-synonymous mutations were at 2.2-fold increased risk for

272 rotein receptor (LDLR), carriers of rare non-synonymous mutations were at 4.2-fold increased risk for

273 Several synonymous mutations were detected in exons 4 and 5 for

274 timated that between 1 in 34 and 1 in 12 non-synonymous mutations were drivers, accruing at constant

275 d repetitively in different patients, and no synonymous mutations were found, indicating that the obs

276 the mean ratio of nonsynonymous mutations to synonymous mutations were greater in clones derived from

277 Forty-five non-synonymous mutations were identified in the target genes

278 ence which are important for vRNA packaging, synonymous mutations were introduced into the full-lengt

279 Although synonymous mutations were previously thought to be silen

280 Synonymous mutations were the primary discriminatory var

281 Synonymous mutations, which change the DNA sequence but

282 Synonymous mutations, which do not alter the protein seq

283 trong increase in selection pressure against synonymous mutations, which propagates into the adjacent

284 spite the fact that it would be disrupted by synonymous mutations, which raises the possibility of ev

285 beta-lactamase CTX-M-15, and find three non-synonymous mutations with increased resistance against m

286 de the most compelling evidence to date that synonymous mutations with non-neutral fitness effects ma

287 resented in dbSNP and included predicted non-synonymous mutations with possible phenotypic effects.

288 The association of synonymous mutations with potentially important phenotyp

289 whole genome sequencing, we identified a non-synonymous mutation within an uncharacterized LacI-type

290 Interestingly, a low-frequency synonymous mutation within the MATN2 gene was identified

291 ancer-associated genes that are enriched for synonymous mutations within the same samples.

292 Resistance is caused by non-synonymous mutations within the target of ipflufenoquin/

293 s, we have rescued mutant viruses containing synonymous mutations within these highly conserved regio