ライフサイエンスコーパス: synovium

1 c to the microvasculature of human arthritic synovium.

2 he inflammatory and erosive processes in the synovium.

3 induced apoptosis of macrophages in inflamed synovium.

4 subchondral bone, and the joint capsule with synovium.

5 ling IdU-positive cells were detected in the synovium.

6 associated with CD14(+) monocytes in the RA synovium.

7 eflects the proteins present in the inflamed synovium.

8 nd is expressed in rheumatoid arthritis (RA) synovium.

9 th the amount of TSG-6 immunostaining in the synovium.

10 se to tryptase-positive mast cells in the RA synovium.

11 nd hyperplasia of synovial tissue seen in RA synovium.

12 h expression of galectin 3 in the rheumatoid synovium.

13 chronic inflammatory immune responses in the synovium.

14 SF MSCs are likely to originate from synovium.

15 ted by immunohistochemical analysis of mouse synovium.

16 oduced by chondrocytes, subchondral bone and synovium.

17 bsequently migrate out of the blood into the synovium.

18 l recruitment, using an in vitro model of RA synovium.

19 n-11 as essential for the development of the synovium.

20 matory synovitis, using collagenase-digested synovium.

21 g to RA ST was 3-fold greater than to normal synovium.

22 AR-2-expressing cells was investigated in RA synovium.

23 xpression was similarly down-regulated in RA synovium.

24 (FLS) lines were established from rheumatoid synovium.

25 urishing the inflamed and hyperproliferative synovium.

26 activation of IRF-3 was also increased in RA synovium.

27 in RA synovium compared with osteoarthritis synovium.

28 te the expression of these factors in the RA synovium.

29 latter may involve the immediately adjacent synovium.

30 ncreased as compared to normal cartilage and synovium.

31 macrophages, which are abundant in inflamed synovium.

32 on, MC hyperplasia was seen in the arthritic synovium.

33 ficantly higher than in normal cartilage and synovium.

34 way from the lymph nodes toward the inflamed synovium.

35 binding site on endothelial syndecan-3 in RA synovium.

36 rs the transition from the lymph node to the synovium.

37 te p38 are activated in rheumatoid arthritis synovium.

38 n the vast majority of cells in the inflamed synovium.

39 e gene expression, particularly IL-8, in the synovium.

40 s a prominent differentiating feature of PsA synovium.

41 lining by immunohistologic staining of human synovium.

42 tilage was present in close association with synovium.

43 ases (TIMPs) in both articular cartilage and synovium.

44 Tie2 regulates angiogenesis in inflammatory synovium.

45 sion dramatically increased in the arthritic synovium.

46 inflammatory cytokine production in inflamed synovium.

47 ed decreased hMSH6 and increased hMSH3 in RA synovium.

48 ated kinases were significantly higher in RA synovium.

49 that Tie2 and Ang1 were elevated in human RA synovium.

50 to distinct microdomains within the inflamed synovium.

51 mphocyte accumulation seen in the rheumatoid synovium.

52 lation and positioning within the rheumatoid synovium.

53 y higher TBX5 expression than in OASF and OA synovium.

54 peptidergic fiber density in the ankle joint synovium.

55 e response to therapy than appearance of the synovium.

56 icroarray expression data from cartilage and synovium.

57 ovial fibroblasts (RASFs), key players in RA synovium.

58 ng cytokine synthesis at central sites in RA synovium.

59 is higher in RA than in osteoarthritis (OA) synovium.

60 the presence of endothelial gaps in inflamed synovium.

61 normal human tissues including normal human synovium.

62 for the microvasculature of human arthritic synovium.

63 s accumulated in the articular cartilage and synovium after ACLT, and selective elimination of these

64 on, as well as protein levels of CTGF in the synovium, after treatment with the TSP-1-derived peptide

65 nt interzone cells identifies in adult mouse synovium an MSC population largely negative for the skel

66 he number of pro-inflammatory macrophages in synovium and (c) improves the severity of synovitis and

67 latent TGF-beta1 are secreted from both the synovium and all three articular cartilage zones (superf

68 PPD) and monosodium urate (MSU) deposited in synovium and articular cartilage initiate joint inflamma

69 drocytes gain access to active TGF-beta: the synovium and articular cartilage secrete latent TGF-beta

70 driven acquired immune response in psoriatic synovium and blood was reported.

71 an directly visualize and monitor changes in synovium and bone that precede actual bone erosion.

72 on of immune and inflammatory cells into the synovium and by hyperplasia of the fibroblasts in the sy

73 The alpha7 receptor is expressed in the synovium and by synoviocytes.

74 opathologic injury, and C3 deposition in the synovium and cartilage in wild-type and fH(+/-) mice.

75 istry revealed the presence of MMP-10 in the synovium and cartilage of an IL-1 plus OSM-induced model

76 C3 deposition in the synovium and cartilage was significantly reduced (p < 0.

77 diverse subset of proteins and peptides from synovium and cartilage, different from that bound by nor

78 atory cells, such as macrophages, invade the synovium and cause cartilage and bone destruction.

79 luated their expression and regulation in RA synovium and cultured fibroblast-like synoviocytes (FLS)

80 the expression and function of PI3Kdelta in synovium and cultured fibroblast-like synoviocytes (FLS)

81 al antibody to human PAR-2, expression in RA synovium and cultured synovial fibroblasts was character

82 R were demonstrated in RA and osteoarthritis synovium and cultured synoviocytes.

83 of increased PI3Kdelta expression in both RA synovium and cultured synoviocytes.

84 ease in MMP expression in both cartilage and synovium and decreased TIMP-1 expression in the articula

85 Gadd45beta expression were analyzed in human synovium and fibroblast-like synoviocytes (FLS) using qu

86 The expression of alpha7R in human synovium and fibroblast-like synoviocytes (FLS) was dete

87 of TNF-alpha in cell-cell interactions in RA synovium and for the effectiveness of TNF-alpha blockade

88 s (MKK-4 and MKK-7) are phosphorylated in RA synovium and form a complex with JNK in fibroblast-like

89 re isolated from normal and rheumatoid human synovium and from normal or arthritic joints of wild-typ

90 Complement factor C3 is made in rheumatoid synovium and has been proposed to be a crucial driver of

91 ells, and they find a niche both in inflamed synovium and in lymph nodes.

92 eks after induction of inflammation, both in synovium and in other periarticular tissues.

93 n-specific autoimmunity in the brain, heart, synovium and intestines, allergic disorders of the lung

94 ced by the chondrocytes themselves or by the synovium and other surrounding tissues, even in the abse

95 MSC populations were derived from adult synovium and periosteum.

96 GF(+)/CD68(+) and VEGFR1(+)/CD11b(+)) in the synovium and peripheral blood of HJD subjects along with

97 nerves from both fore and hind limbs, stifle synovium and perisynovial adipose tissue, urinary bladde

98 citrullinated CRT is overabundant in the RA synovium and potentiates SE-activated signaling in vitro

99 less methylated in rheumatoid arthritis (RA) synovium and RASF than in osteoarthritis (OA) samples.

100 iogenesis and autoimmune inflammation in the synovium and represents a protective mechanism preventin

101 ectomy effectively controls the hypertrophic synovium and resultant bleeding, and can be used safely

102 accumulation of TSP2 protein in the inflamed synovium and resulted in a prompt inhibition of lesional

103 es from OA-affected and normal cartilage and synovium and selected 22 genes in addition to the estrog

104 In addition, expression of IFNbeta in synovium and serum was decreased, potentially contributi

105 tures in the knee such as cruciate ligament, synovium and some blood vessels are formed by cells deri

106 ivo visualization of abnormal vascularity in synovium and subchondral bone that have not been apparen

107 activated PBMCs that migrate to the inflamed synovium and subchondral bone, where they are exposed to

108 out, 3) HA residence times in the SF, and 4) synovium and subsynovium cellularity of the knee joints

109 ecruiting and retaining leukocytes in the RA synovium and suggest that targeting JAM-C may be importa

110 ur data indicated SOX5 levels were higher in synovium and synovial fluid from RA compared to osteoart

111 d in the microvasculature of human arthritic synovium and that has the potential to be developed as a

112 rotein is expressed in RA and osteoarthritis synovium and that the protein is found primarily in the

113 the phenotype of infiltrating B cells in the synovium and the unexpected role for B cells in bone hom

114 ages, infiltrating macrophages from inflamed synovium and tumor-associated macrophages.

115 /6 expression was significantly higher in RA synovium and was localized to the sublining mononuclear

116 This RNA message has been found only in OA synovium and, if translated, would result in a protein i

117 ed on cells derived from human thymus, skin, synovium, and cartilage, and its expression is enhanced

118 onfirmed that IKKepsilon was activated in RA synovium, and immunostaining showed localization of pIKK

119 inflammation, mononuclear cell influx in the synovium, and increased expression of catabolic factors,

120 protein is expressed in rheumatoid arthritis synovium, and loss of p53 function through somatic mutat

121 re strongly expressed in psoriatic arthritis synovium, and serum matrix metalloproteinases-3 may be a

122 ained from 3 different sources (bone marrow, synovium, and skin) to test the hypothesis that synovial

123 luid in the pisotriquetral recess, enhancing synovium, and, less commonly, pisotriquetral bone marrow

124 Inflammation and angiogenesis in the synovium are associated with OA.

125 yte-independent CTMCs and identify arthritic synovium as a model system by which to gain insight into

126 atively categorized by the appearance of the synovium as one of the following: frondlike and hypertro

127 NF200+, GAP-43+, and TH+ nerve fibers in the synovium, as well as a significant increase in joint pai

128 as analyzed in human articular cartilage and synovium, as well as in dorsal root ganglia (DRG) and sp

129 arthritis, EPCs were recruited into inflamed synovium at the acute phase of disease and formed de nov

130 ere obtained from RA and osteoarthritis (OA) synovium at the time of total joint replacement.

131 s: (a) decreases macrophages infiltration in synovium, (b) reduces the number of pro-inflammatory mac

132 bola virus/Kikwit found that the large joint synovium became immunopositive beginning on postinfectio

133 lude primarily the joint capsule, ligaments, synovium, bone, and in the knee, the outer edge of the m

134 e a dominant source of IL-6 and RANKL in the synovium, both of which are therapeutic targets for infl

135 lycoprotein that is not expressed in healthy synovium but is elevated in the rheumatoid joint, where

136 imination of spirochetes from heart base and synovium but not vascular walls, tendons, or ligaments.

137 e-SCID mouse chimeras infiltrated rheumatoid synovium but preferentially homed to lymph nodes.

138 is, the target of the immune response is the synovium but the SpA disorders target the tendon, ligame

139 AT-1 expression in rheumatoid arthritis (RA) synovium, but mechanisms that induce synovial IFN expres

140 trated abundant MKK-4 and MKK-7 in RA and OA synovium, but the levels of phosphorylated kinases were

141 verning trafficking of immune cells into the synovium by chemokines were identified, but not in situ

142 fibroblasts also promote inflammation in the synovium by producing cytokines and chemokines.

143 ively inadequate oxygen delivery in affected synovium, can both be objectively and non-invasively eva

144 sed by the accumulation of leukocytes in the synovium, cartilage destruction and bone erosion.

145 P1 is abundantly expressed in the rheumatoid synovium, CD47-TSP1 interaction is proposed to be a key

146 and progressive inflammatory disorder of the synovium characterised by destruction of bone and cartil

147 al neoplastic proliferation arising from the synovium characterized by a minor population of intratum

148 In human-synovium chimeric mice, MRE11A(low) T cells were tissue-

149 PAR-2 was substantially up-regulated in RA synovium compared with control synovial tissue from pati

150 sphorylation was significantly greater in RA synovium compared with osteoarthritis synovium.

151 urprisingly, abundant MSI was observed in RA synovium compared with osteoarthritis tissue.

152 cursor-containing population in the inflamed synovium, comprising a subset distinct from conventional

153 We previously reported that human synovium contains cells that, after culture expansion, d

154 nd protein were unexpectedly low in human RA synovium despite abundant NF-kappaB activity.

155 The rheumatoid synovium displays characteristics of Toll-like receptor

156 d WISP1, which we found overexpressed in the synovium during experimental OA, may conduce to OA patho

157 t signaling pathway are overexpressed in the synovium during experimental OA.

158 among the first cells that accumulate in the synovium during osteoarthritis, both exerting a pathogen

159 lymphoid microarchitectures in the inflamed synovium: ectopic GCs; T cell-B cell aggregates lacking

160 ritical factor mediating inflammation in the synovium, enthesis, and bone.

161 ted that PI3Kdelta is highly expressed in RA synovium, especially in the synovial lining.

162 In rheumatoid arthritis (RA), the inflamed synovium exhibits characteristic infiltration of macroph

163 4+ T cells and macrophages in the rheumatoid synovium express elevated levels of CD80, increasing the

164 osteoarthritis (OA), and psoriatic arthritis synovium, exRNA was detectable only in the RA synovial l

165 n of macrophages, and neoangiogenesis in the synovium following hemarthrosis.

166 nchymal cells also contributed to tendon and synovium formation.

167 The normal synovium forms a membrane at the edges of joints and pro

168 ncrease in AT(1) receptor protein content in synovium from acutely and chronically inflamed rat knee

169 Additionally, analysis of the synovium from arthritic paws indicated that the same CD4

170 s were isolated from articular cartilage and synovium from calf stifle joints and cultured as monolay

171 The synovium from Crry-Tg mice without CIA contained the mRN

172 whereas there was little or no expression in synovium from healthy donors.

173 with rheumatoid arthritis and compared with synovium from healthy donors.

174 EPCs were 4-fold more numerous in inflamed synovium from mice with anti-type II collagen antibody-i

175 by double immunofluorescence in the inflamed synovium from patients with rheumatoid arthritis and com

176 A for the Crry transgene, by RT-PCR, and the synovium from transgenic mice with CIA exhibited little

177 This role depends on the synovium functioning as an ultrafilter that reflects HA

178 s expressed as a protein in vivo in human OA synovium, functions as an aggrecanase, and cleaves other

179 gressive tumour-like behaviour of rheumatoid synovium have also been implicated.

180 tis (RA), the effects of methotrexate on the synovium have been described solely in RA.

181 psoriatic arthritis and rheumatoid arthritis synovium have divergent histopathologic features that in

182 cture, knee OA was assessed by cartilage and synovium histology in addition to bone morphology.

183 factor alpha generation from inflamed human synovium in a dose-dependent manner (P < 0.05).

184 M expression on leukocytes, endothelium, and synovium in joint sections of peptidoglycan-polysacchari

185 cytokine cascade in the in vitro cultures of synovium in joints of patients with RA led to studies of

186 e molecular cross-talk between cartilage and synovium in osteoarthritis, the most widespread arthriti

187 For chlamydiae, residence in the synovium in patients with acute or chronic Chlamydia-ind

188 This first analysis of the synovium in patients with chronic pyogenic arthritis ide

189 epair in mice and was switched on in injured synovium in prospective areas of cartilage formation, wh

190 itative differences in the appearance of the synovium in TKA between particle-induced synovitis, infe

191 ion and leukocyte recruitment in a facsimile synovium in vivo using the murine air-pouch model.

192 To identify stem cells in the synovium in vivo, a double nucleoside analog cell-labeli

193 of this study was to identify MSCs in native synovium in vivo.

194 ent of neutrophils to the peritoneum and the synovium in wild-type mice, but not in GEF-H1(-/-) mice.

195 le of JAM-C in leukocyte retention in the RA synovium, in vitro and in situ adhesion assays and RA ST

196 ctants in synovial fluid from the rheumatoid synovium, including CCL2, CCL7, and CXCL8.

197 reviously, the basis for organization of the synovium into a tissue was unknown.

198 Gdf5 upregulation in articular cartilage and synovium is a generic response to knee injury that is de

199 etween soluble mediators within the inflamed synovium is a key factor that governs the pathologic out

200 The synovium is a mesenchymal tissue composed mainly of fibr

201 iltration into the rheumatoid arthritis (RA) synovium is a multistep process in which leukocytes leav

202 arthritis, whether C3 synthesized within the synovium is important in promoting inflammation.

203 In rheumatoid arthritis (RA), the synovium is infiltrated by mononuclear cells that influe

204 erstood and the pathophysiologic role of the synovium is only beginning to be elucidated.

205 t the expression of IFN response genes in RA synovium is regulated by interplay between TNFalpha and

206 ic basis for the differing roles of skin and synovium is suggested by a landmark animal study that de

207 In rheumatoid arthritis, the synovium is the site of inflammation, and it participate

208 Assessing the pathology of the synovium, its thickening and increased vascularity throu

209 r and destruction of target tissues, such as synovium (joint lining).

210 d to bare areas and the associated cartilage-synovium junction.

211 by chronic inflammatory infiltration of the synovium, leading to eventual cartilage and bone destruc

212 protein (COMP) is a component of cartilage, synovium, ligament, and tendon, yet its normal function

213 MSU crystals also were injected into mouse synovium-like subcutaneous air pouches.

214 eta-HSD1) enzyme which is expressed in bone, synovium, liver and adipose tissue.

215 Subchondral bone and synovium may be responsible for nociceptive stimuli, and

216 growth factor VEGF generated by the inflamed synovium may promote angiogenesis, thereby contributing

217 ural knee joint components (i.e., cartilage, synovium, meniscus, subchondral bone) were examined by h

218 In the synovium, neutrophils interact with resident fibroblast-

219 ero (-0.03 +/- 0.18, n= 21), confirming that synovium, not initial lymphatic endothelium, is the refl

220 he protein was detected in cell lysates from synovium obtained from OA patients.

221 The histologic features of OA synovium obtained from patients undergoing primary surge

222 In total, the synovium of 28 of 30 rhesus macaques with terminal filov

223 and this serine protease is abundant in the synovium of arthritic mice.

224 demonstrate the presence in inflamed knee OA synovium of clonally expanded, Ag-driven B cells that ma

225 -mediated disease that primarily affects the synovium of diarthrodial joints.

226 alpha mRNA with HIF-1alpha expression in the synovium of HJD subjects, implicating hypoxia in the neo

227 lectins, cytokines, and collagenase-3 in the synovium of IL-17R-/- mice.

228 bodies and bound targets within the inflamed synovium of mice with CIA.

229 FR was highly expressed and activated in the synovium of mice with collagen-induced arthritis and pat

230 Latent infection could be reactivated in the synovium of normal mice when treated with Cytoxan and th

231 the level of ADAMTS-12 in the cartilage and synovium of patients with both osteoarthritis and rheuma

232 ike synoviocytes (RA-FLSs) isolated from the synovium of patients with RA.

233 alpha (TNFalpha) have been identified in the synovium of patients with reactive and undifferentiated

234 An abundance of mast cells are found in the synovium of patients with rheumatoid arthritis (RA).

235 e concentration of ADAMTS-7 in cartilage and synovium of patients with rheumatoid arthritis is signif

236 ulation of PD-1(hi)CXCR5(-)CD4(+) T cells in synovium of patients with rheumatoid arthritis.

237 similar and strong expression pattern in the synovium of patients with rheumatoid arthritis.

238 and metalloproteinase gene expression in the synovium of PsA patients.

239 port that C5orf30 is highly expressed in the synovium of RA patients compared with control synovial t

240 We observed IL-17(+)Foxp3(+) T cells in the synovium of subjects with active rheumatoid arthritis (R

241 ells (ECs) and fibroblasts isolated from the synovium or skin of RA patients were established in cocu

242 o SCID mice engrafted either with rheumatoid synovium or with human lymph nodes.

243 these patients, the inflammatory response in synovium persists.

244 enchymal Stem Cells (MSC), and with adjacent synovium plays key roles in joint disease including the

245 cell types of the rheumatoid arthritis (RA) synovium, possess phenotypic and molecular characteristi

246 s are involved in an NK cell increase in the synovium, possibly by expressing CXCL10 in inflamed join

247 in which NGF secreted by FLS into PsA and RA synovium promotes the survival of activated autoreactive

248 To model RA synovium, RA synovial fibroblasts (RASFs) were coculture

249 nown about the validity of contrast enhanced synovium representing synovitis.

250 competition for limited resources within the synovium, resulting in the destabilization of FOXP3 expr

251 stochemical analysis of subchondral bone and synovium revealed RANK-positive perivascular mononuclear

252 yS and APRIL were explored by treating human synovium-SCID mouse chimeras with the APRIL and BLyS dec

253 A layer of synovium separated the anterior bundle from the more sup

254 Human synovium-severe combined immunodeficiency (SCID) mouse c

255 The arthritic synovium showed expression of uPA and uPAR in neutrophil

256 s (ASCs), mesenchymal stem cells (MSCs), and synovium stem cells (SSCs) but also induce chondrogenesi

257 but only minimal expression of OPN-R, in RA synovium, suggesting that cleaved OPN is released into s

258 metabolically active infection state in the synovium, suggesting that they may be susceptible to ant

259 receptors are up-regulated in the rheumatoid synovium, suggesting that this receptor could be a thera

260 a TNF-dependent cascade in active rheumatoid synovium, suggesting that TNF might be a therapeutic tar

261 evels of these T cells were increased in the synovium, suggesting the T cells may have had systemic e

262 artilage deterioration, intimal cells in the synovium surrounding the joint space became hyperplastic

263 In RA synovium, TBX5 expression was primarily localized to the

264 ulation of T cells has been identified in RA synovium that phenotypically resembles cytokine-activate

265 existence of resident MSCs in the knee joint synovium that undergo proliferation and chondrogenic dif

266 cell (EPC) recruitment into engrafted human synovium that was injected intragraft with CXCL16-immuno

267 ctopic lymphoid structures in the rheumatoid synovium, their frequency, and role in pathogenesis.

268 XRs are present in rheumatoid arthritis (RA) synovium, these results suggest that LXR-mediated pathwa

269 functional significance of cadherins in the synovium, this study was undertaken to determine whether

270 Entheses are frequently juxtaposed to synovium, thus forming SECs.

271 interrogated gene expression profiles of SLE synovium to gain insight into the nature of lupus arthri

272 specific Wnt proteins, when expressed in the synovium, to induce OA pathology.

273 During the course of RA, the synovium transforms into a hyperplastic invasive tissue

274 ressed Wnt5a, Wnt8a, Wnt16, and WISP1 in the synovium using adenoviral vectors.

275 A novel synovium vascular window model was established to study

276 ibution of mediators produced locally in the synovium versus those circulating systemically is unknow

277 In RA synovium, visfatin/PBEF was predominantly expressed in t

278 transgenic mice significantly decreased knee synovium volume (by 50% from the baseline level) and sig

279 proportion of HA molecules reflected by the synovium was 57-75%.

280 hylation of the TBX5 promoter in RASF and RA synovium was accompanied by higher TBX5 expression than

281 Before treatment, PsA synovium was characterized by a predominant expression o

282 IFN-induced chemokine gene expression in synovium was constrained in active systemic JIA compared

283 arthritis model, EPC recruitment to inflamed synovium was evaluated.

284 its ligand, angiopoietin 1 (Ang1), in human synovium was examined by immunohistochemistry and Wester

285 ere euthanatized, joints were evaluated, and synovium was harvested for histology and immunohistochem

286 Expression in synovium was mainly in the intimal lining.

287 rization and EPC accumulation in mouse ankle synovium was measured.

288 An immunohistochemical study of human OA synovium was performed.

289 llamine, the pattern of MMR expression in RA synovium was reproduced (high hMSH3, low hMSH6).

290 s factor alpha and interleukin-1beta from RA synovium was substantially inhibited by ENMD-1068, in a

291 t adjacent to articular cartilage, where the synovium was that of bursae or tendon sheaths.

292 o provide evidence of DNA damage in inflamed synovium, we analyzed synovial tissues for microsatellit

293 novial fluid (SF) bathes joint cartilage and synovium, we reasoned that a comparative analysis of its

294 jury, double nucleoside-labeled cells within synovium were embedded in cartilage-specific metachromat

295 rmation of de novo blood vessels in inflamed synovium were evaluated.

296 Fibroblasts obtained from RA synovium were grown, and conditioned medium was obtained

297 Levels of p-ERK in the synovium were higher in RA patients than in normal indiv

298 sented HLA-DR self peptides from a patient's synovium were identified, synthesized, and reacted with

299 early and more extensive infiltration of the synovium with neutrophil leukocytes was the most promine

300 cing inflammatory responses in cartilage and synovium with pain-related factors in glial cells.