ライフサイエンスコーパス: syntenic

1 ea that the majority of Drosophila genes are syntenic.

2 een 52 and 57 kbp in length that are largely syntenic.

3 in animal models where a single copy of the syntenic 16p11.2 region has been deleted have revealed m

4 ral cortex from mouse models with CNV of the syntenic 7qF3 region and lymphoblast lines from 34 membe

5 are striking: most genes are single copy and syntenic across mammalian genomes, whereas most genes ar

6 region around the origin of replication was syntenic across the genus.

7 a combination of phylogenetic analyses with syntenic alignment of mammalian CD59 genes to identify t

8 At the genome level, syntenic alignments between sorghum (Sorghum bicolor) an

9 al spans in their genomic context, including syntenic alignments with other kinetoplastid organisms.

10 e proteins, as a model for gene evolution by syntenic alignments with sorghum and rice, two genomes t

11 haplotype" (or "haploid genotype") refers to syntenic alleles inherited on a single chromosome, and w

12 Genetic, evolutionary and syntenic analyses indicate that chIFN-kappa is a type I

13 bination of phylogenetic, splicing site, and syntenic analyses revealed that zebrafish have two per1

14 gh comprehensive sequence, phylogenetic, and syntenic analyses, we fully describe the identification

15 Genome syntenic analysis between spinach and sugar beet suggest

16 Syntenic analysis of genome structure revealed that the

17 Syntenic analysis of Glossina relative to Drosophila mel

18 Syntenic analysis of regions harbouring GmSNAP genes in

19 e orthologous relationships based on sharing syntenic anchors, collocating in the same syntenic block

20 The proportion of genes syntenic and collinear within each synteny block is rela

21 rived open reading frames (ORFs) that showed syntenic and copy number variation among species, but we

22 ferentiation complex (EDC) locus comprises a syntenic and linear cluster of genes whose concomitant e

23 n DNA replication and genome maintenance, is syntenic and linked to Trp53 in mice and humans.

24 species elements (LIMEs), which include both syntenic and nonsyntenic regions, of at least 100 identi

25 by phylogenetic gene family trees help infer syntenic and orthologous relationships.

26 Comprehensive syntenic and phylogenetic analyses support our hypothesi

27 P compiles gene and gene family information, syntenic and phylogenetic context and tissue-specific tr

28 These two genomes are highly syntenic and show a high degree of sequence conservation

29 In better studied species, ODG can perform syntenic annotation translations or rapidly identify cha

30 t in all five genomes, and display conserved syntenic architecture with respect to gene order, orient

31 ed-end sequences (2 x 76 bp) provides a good syntenic assembly with >95% high-quality coverage (more

32 QTL-peak candidate genes delineated are syntenic between rat and human genomes, increasing clini

33 located between the lplA and glnQ genes are syntenic between the two phytoplasmas and contain the ma

34 netic mapping revealed that 83% of ESTs were syntenic between wheat and rice, a far higher level of s

35 nic blocks across species, the disruption of syntenic blocks (via chromosomal inversion events) and i

36 or themes are addressed: the conservation of syntenic blocks across species, the disruption of synten

37 char also revealed extensive conservation of syntenic blocks across species, which was generally cons

38 Identification of conserved syntenic blocks across these genomes suggests a large nu

39 Comparison of syntenic blocks across this large genomic data set confi

40 nally, we identify and analyze the conserved syntenic blocks among reconstructed ancestral genomes an

41 y manifested as chromosomal rearrangement of syntenic blocks and DNA insertions/deletions.

42 ng syntenic anchors, collocating in the same syntenic blocks and sharing the same annotated protein f

43 other hand, an analysis of the disruption of syntenic blocks between species allowed the identificati

44 ey comparative alignment type and search for syntenic blocks between two sequences and zoom in to vie

45 C6 were the result of complex reshuffling of syntenic blocks from three (AK3, AK5 and AK11), three (A

46 Among the >300 syntenic blocks identified are segments of over 40 Mb wi

47 The largest syntenic blocks occur in regions with low meiotic recomb

48 chicken, turkey and zebra finch, identifying syntenic blocks of at least 250 kb.

49 e rate in another, when comparing homologous syntenic blocks of the genome.

50 he location and orientation of 53 C. hystrix syntenic blocks on the seven cucumber chromosomes, and a

51 Comparisons of syntenic blocks reveal clear structural similarities in

52 vely reshuffled, leading to a minimum of 921 syntenic blocks shared between the species.

53 ECRbase features a database of syntenic blocks that recapitulate the evolution of rearr

54 Arabidopsis' unique gene content is found in syntenic blocks that were formed during the most recent

55 Micro-syntenic blocks were detected in apple (Malus x domestic

56 sed for a fine-scale comparison of conserved syntenic blocks with the human and canine genomes.

57 tly ordered anchors between the two genomes (syntenic blocks).

58 s repetitive sequences, telomeres, conserved syntenic blocks, and expansion of pathogenicity-related

59 netic networks were found for individual rye syntenic blocks.

60 er scaffolds on the basis of the analysis of syntenic blocks.

61 ethod, with 3,941 ORFs present in conserved, syntenic blocks.

62 ra genome at many junctions between adjacent syntenic blocks.

63 hat repeats and repeat-clusters are found at syntenic break points between E. histolytica and E. disp

64 e organized in clusters, frequently found at syntenic break points providing insights into their cont

65 pped the locations of 31 major human-chicken syntenic breakpoints.

66 ic genes, many of which are found at or near syntenic breaks, implicating evolutionary breakpoint reg

67 tegrative Web-based system to find and align syntenic chromosomal regions and visualize the output in

68 ed by the absence of group Q homologs on the syntenic chromosomal regions in Arabidopsis thaliana (Br

69 The gl8a and gl8b genes map to syntenic chromosomal regions, have similar, but not iden

70 s chromosomes in the two species from highly syntenic chromosomes in most cases to chromosomes with a

71 JY-1-like sequences are present on syntenic chromosomes of other vertebrate species, but la

72 (lws1, lws2, and miR-726) occur in a single syntenic cluster.

73 Conserved syntenic clusters of tRNA genes and 5S rRNA genes occur

74 , phylogenetic profiles (presence/absence of syntenic conservation across 17 species), and locations

75 as brain-development genes in primates, and syntenic conservation across angiosperms, such as single

76 cat, human, and mouse highlights regions of syntenic conservation and species-specific gene rearrang

77 everal previous studies examined genome-wide syntenic conservation to infer the contents of ancestral

78 genomes followed by post-processing of those syntenic datasets to identify and plot gene retention pa

79 e family expansion are often associated with syntenic discontinuities that-along with gene divergence

80 ther gene that resembles CRH in sequence and syntenic environment.

81 The results show that a syntenic expression site is present in all strains of A.

82 oximately 25 kb of all 4 linear plasmids was syntenic for orthologous genes for plasmid maintenance o

83 e timing of gene set duplications located on syntenic gamma blocks.

84 ete basal fungal lineage, the sex locus is a syntenic gene cluster governing sexual reproduction in w

85 We also discovered a syntenic gene cluster of transcription factors that regu

86 Strikingly dissimilar conserved syntenic gene content, gene sequence diversity signature

87 chromosomes, with most genes maintaining as syntenic gene pairs.

88 subfunctionalization and/or fractionation of syntenic gene sets, and conserved noncoding sequence con

89 erved housekeeping genes are concentrated in syntenic gene-rich blocks, whereas virulence genes are d

90 eudoobscura We find that while the original (syntenic) gene copy has generally retained the ancestral

91 including insertions of high numbers of non-syntenic genes and a high rate of tandem gene duplicatio

92 ic changes; it has acquired more than 80 non-syntenic genes and only 13 ancestral genes are shared am

93 The high frequency of non-syntenic genes and rapid local gene evolution correlate

94 Syntenic genes are more highly expressed than nonsynteni

95 usual in mammals, whereas single-copy highly syntenic genes are rare for flowering plants.

96 s were highly conserved with less than 1% of syntenic genes being subject to differential fractionati

97 ed a more relaxed selection pressure for non-syntenic genes compared to syntenic genes, and gene onto

98 Local duplication of non-syntenic genes contributed significantly to the expansio

99 lative codon bias is broadly conserved among syntenic genes from different trypanosomatids.

100 to establish the chromosomal arrangement of syntenic genes from model grass species.

101 nd gene ontology analysis indicated that non-syntenic genes may be enriched in functions involved in

102 Insertions of non-syntenic genes occurred at a similar rate along the chro

103 These non-syntenic genes on 3B have high sequence similarity to at

104 icken leptin together with a cluster of five syntenic genes provided the final proof for its identifi

105 whereas, by applying the same criteria, non-syntenic genes represent on average only 10 % of the pre

106 The few variably fractionated syntenic genes that were identified are unlikely to cont

107 Between these two genomes, syntenic genes were highly conserved with less than 1% o

108 comparisons of 60 diverse inbred lines, non-syntenic genes were six times more likely to be variable

109 pressure for non-syntenic genes compared to syntenic genes, and gene ontology analysis indicated tha

110 These non-syntenic genes, including prolamin and resistance-like g

111 re six times more likely to be variable than syntenic genes, suggesting that comparisons among additi

112 plication and are therefore younger than the syntenic genes.

113 are under different selection pressure than syntenic genes.

114 large-scale presence/absence variation among syntenic genes.

115 e database since its last release, including syntenic genome regions for human poly(A) sites in seven

116 We further show that orthologs in syntenic genomic blocks are more likely to share correla

117 reakage and fusion events based on conserved syntenic genomic blocks lead to conserved patterns of ka

118 es resulted in identification of a conserved syntenic genomic island consisting of up to 33 core gene

119 first report of a diverse family of related syntenic genomic islands with a deep evolutionary origin

120 mals because no direct homologs exist at the syntenic genomic locus in metatherian (marsupial) or pro

121 binds to a core group of approximately 1200 syntenic genomic regions in both species, with these con

122 om mammals to fish, that are maintained in a syntenic group across vertebrates.

123 h GC-content observed for the chicken leptin syntenic group suggests that other similar clusters of g

124 In this syntenic group, the RNA-binding protein 28 (RBM28) was i

125 nd about 20% for S. cerevisiae, as lacking a syntenic homolog because of local indels or scrambled sy

126 Fagin also delineates whether a gene has no syntenic homolog because of technical or biological reas

127 ng syntenic homolog), NTic (has a non-coding syntenic homolog), and Unknown (has no detected syntenic

128 , and further subclasses: AAic (has a coding syntenic homolog), NTic (has a non-coding syntenic homol

129 tenic homolog), and Unknown (has no detected syntenic homolog).

130 Furthermore, the repeated recruitment of syntenic homologs from large gene families strongly impl

131 biogenesis were identified, 14 of which were syntenic homologs in maize and S. viridis.

132 locus maps to a 3.9-Mb region, with complete syntenic homology to human chromosome 14, that contains

133 gene is located on chromosome 2, a region of syntenic homology with human chromosome 20, and in a reg

134 region on distal mouse chromosome 1 and its syntenic human counterpart 1q23-42 show strong evidence

135 ptibility locus Nba2 on chromosome 1 and the syntenic human locus are associated with a loss of immun

136 GEDDs along the mouse chromosomes that were syntenic in human.

137 ed the tree tests, the bulk (8 of 10) remain syntenic in the genomes with only a few (3 of the 10) ha

138 mparative genomics approaches are limited to syntenic inference and recombination is suppressed withi

139 sequence validated by genetic, physical and syntenic information.

140 o introduce a heterozygous deletion into the syntenic interval on C57BL/6 mouse chromosome 16.

141 Seventeen conserved syntenic linkage blocks making up the rye and barley gen

142 These profiles were cross-referenced with syntenic locations exhibiting hippocampal DNA methylatio

143 hologs of each PAI can be found in conserved syntenic locations in other Pseudomonas species, indicat

144 an and rat, with major clusters occurring in syntenic locations.

145 Similarly, the mouse clade B serpins map to syntenic loci at 13A3.2 and 1D, respectively.

146 that ICP1 has evolved to possess one of two syntenic loci encoding an SF1B-type helicase, either of

147 melon and watermelon, we uncovered conserved syntenic loci encoding metabolic genes for distinct cucu

148 R) in approximately 3000 human and zebrafish syntenic loci, we detected approximately 300 pairs of di

149 An identical domain was activated at the syntenic locus in a specific molecular subclass of spont

150 is insufficient to account for the extensive syntenic losses described in Lovell et al.

151 Using syntenic mapping and the functional characterization of

152 es or projected from a related species using syntenic mapping information.

153 Syntenic mapping is well-suited to annotate genomes clos

154 ment with homologs from related species, and syntenic mapping with other cereal species.

155 7 of cultivated and wild cucumbers, and the syntenic melon chromosome I suggested that the paracentr

156 series of rearrangements engineered over the syntenic mouse region, we show that this interval contai

157 and Supt3h promoters, consistent with their syntenic nature.

158 us and duplicated regions to construct local syntenic networks, we show that a shared ancient hexaplo

159 -tree phylogenomic results are inconclusive, syntenic ortholog distances to other species place avoca

160 aize and rice reveals that 13% of genes with syntenic orthologs in both species exhibit conserved imp

161 Nonsyntenic genes that lack syntenic orthologs in other grass species, and thus evol

162 The presence of syntenic orthologs to about 19% of the S. italica TPSs i

163 elated expression patterns compared with non-syntenic orthologs.

164 Although they were syntenic, overlapping a- and b-type ribotype genomes har

165 f the genes present in the four genomes were syntenic paralogs (ohnologs) generated by the pre-gamma,

166 known as homeologs, homoeologs, ohnologs, or syntenic paralogs, is uneven between duplicate regions.

167 These syntenic patches are often not colinear, however, and fo

168 d core proteome of about 6200 genes in large syntenic polycistronic gene clusters.

169 lting from differential fractionation in the syntenic portion of the genome using two whole-genome de

170 ns, insertions, or deletions) and located in syntenic positions in at least two genomes.

171 cription factors, maintain their chromosomal syntenic positions throughout angiosperm evolutionary ti

172 The differences in syntenic properties of all annotated gene families, incl

173 look at regions that are especially prone to syntenic rearrangements.

174 n Ae. tauschii with 18 annotated genes and a syntenic region in chromosome 1 of B. distachyon.

175 apping in mice to association mapping of the syntenic region in the human genome.

176 The syntenic region in the mouse is organized and imprinted

177 Furthermore, this response is conserved at a syntenic region in zebrafish cells.

178 Comparative analysis identified a syntenic region of 660 kb in Ae. tauschii with 18 annota

179 Several genes within a syntenic region of human and mouse chromosome 1 are asso

180 amplification at mouse chromosome 9qA1, the syntenic region of human chromosome 11q22.

181 7.6-kb GC-rich repeat units reside within a syntenic region of mouse chromosome 1.

182 in the region of human chromosome 21 and the syntenic region of mouse chromosome 16, trisomy of which

183 hin the human leukocyte receptor complex and syntenic region of mouse chromosome 7, named T cell-inte

184 for both nephropathy and albuminuria in the syntenic region of this interval for both human and mous

185 The human syntenic region of this locus has been previously linked

186 most complete deletion (CD) of the conserved syntenic region on chromosome 5G2.

187 CRISPR/Cas9 technique to delete in mice the syntenic region on chromosome 8 to create a Dnajb1-Prkac

188 ice and conducted association mapping of the syntenic region on human chromosome Xp22.

189 rbor a duplication spanning the entire Hsa21 syntenic region on Mmu10, Mmu16, or Mmu17, respectively.

190 duplication [Dp(11)17 ] (Dup mutant) of the syntenic region on mouse chromosome 11.

191 tion spanning the entire human chromosome 21 syntenic region on mouse chromosome 16 in mice using Cre

192 proximately 56.5% of the human chromosome 21 syntenic region on mouse chromosome 16.

193 B strain, germline-encoded regulation of the syntenic region resulted in decreased miR-15a/16-1.

194 Map3k1 within the syntenic region was expressed in the embryonic mouse gon

195 le genome fractionation requires identifying syntenic regions across genomes followed by post-process

196 atterns, whose parental genes are located in syntenic regions and/or have clear orthologs in at least

197 regions and genes within a single genome or syntenic regions between related genomes.

198 e duplicates as well as the absence of large syntenic regions consisting of duplicated gene copies im

199 ne disease models, and to disease-regulating syntenic regions identified in autoimmune patients on hu

200 In a wider context, the syntenic regions identified in peach, apple and strawber

201 ed an automated system to identify conserved syntenic regions in a primary genome using as outgroup a

202 lications on (1) interspecies comparisons of syntenic regions in human and mouse models; (2) intraspe

203 Finally, analysis of corresponding syntenic regions in the mouse, rat and chimp genomes ind

204 cluster of CslF genes that remain located in syntenic regions of all the grass genomes examined.

205 Single coorthologs of Baf1 are found in syntenic regions of brachypodium (Brachypodium distachyo

206 ies, genome-wide search for oncogenes within syntenic regions of chromosome gain.

207 Analyses of relaxin family genes on syntenic regions of model tetrapods showed that the A ch

208 econd, when mapping the identified CNAs onto syntenic regions of the human genome, we noted that the

209 H3K4me1, and H3K27Ac levels were detected at syntenic regions of the IL-10 locus in mouse neutrophils

210 rries duplications spanning the entire Hsa21 syntenic regions on all three mouse chromosomes.

211 th DS, particularly the impacts of different syntenic regions on these phenotypes.

212 evolutionarily conserved positions, occur in syntenic regions, and evolve under purifying selection.

213 tein sequences, gene models and annotations, syntenic regions, protein families and phylogenetic tree

214 or exhibit no p63 binding in the orthologous syntenic regions, typifying an occupancy lost subset.

215 ition and loss, and rearrangement within the syntenic regions-have shaped the genomes of each parasit

216 ve data set of PSGs by masking less reliable syntenic regions.

217 roach is to limit the search for homologs to syntenic regions.

218 We accomplished this using syntenic relationship among four closely related species

219 ve analyses were undertaken to determine the syntenic relationship between L. perenne/F. pratensis an

220 There is a strong syntenic relationship between the two zebrafish genes an

221 Defining syntenic relationships among orthologous gene clusters i

222 the diploid sorghum genome identified clear syntenic relationships and collinear tracts.

223 genomic analysis identifies chromosome-level syntenic relationships between bottle gourd and other cu

224 Microsynteny networks use genes as nodes and syntenic relationships between genes as edges.

225 s chromosomal rearrangements that break down syntenic relationships occur; however, they do not appea

226 The syntenic relationships of similar genes in other teleost

227 it also facilitates the characterization of syntenic relationships with other cultivated and model l

228 The syntenic relationships with other grass genomes examined

229 Syntenic relationships within the S. caninervis and Phys

230 leta and L. gigantea, and investigated local syntenic relationships.

231 h to organize and interpret massive pairwise syntenic relationships.

232 tissue of any genotype, 90% of which are non-syntenic relative to other grasses.

233 by long-range chromatic interactions through syntenic repeats combined with regional methylation spre

234 th the adjacent Borcs7 gene was humanized by syntenic replacement.

235 1BS aneuploidy are related to rice genes on syntenic rice chromosome 5 short arm (5S).

236 To attain functional information about this syntenic segment in mice, we have generated a 6.9-Mb del

237 mouse mutant with a targeted deletion of the syntenic segment of the mouse X chromosome that phenocop

238 selection signature that spanned a conserved syntenic segment to bovine chromosome 12 on caprine and

239 Chains (putative syntenic sets of anchors) are computed using a dynamic p

240 ls containing a heterozygous deletion of the syntenic SMS critical region, were observed in Rai1(+/-)

241 titive elements, segmental duplications, and syntenic tandem DNA repeats were enriched in methylation

242 The S. aureus and S. epidermidis genomes are syntenic throughout their lengths and share a core set o

243 omato steroidal alkaloid gene cluster and is syntenic to a chromosome 12 region containing another ac

244 small 350-kb amplicon from a region that is syntenic to a much larger locus amplified in human cance

245 d that each seashore paspalum chromosome was syntenic to and highly colinear with a single sorghum ch

246 g proteins of the C4 cycle in S. viridis are syntenic to homologs used by maize.

247 f mouse chromosome 11B3, a 4-megabase region syntenic to human 17p13.1, produces a greater effect on

248 This DNA region, syntenic to human 2q31-32, contains a range of regulator

249 row interval on bovine chromosome 15 that is syntenic to human chromosome 11p12-p11.2.

250 n mice that harbor a chromosomal duplication syntenic to human chromosome 21q.

251 Interestingly, HIVAN1 is syntenic to human chromosome 3q25-27, an interval showin

252 pe and markers located on CFA34, in a region syntenic to human chromosome 3q26.

253 analysis of the introgressed region that is syntenic to human HSA4q21, a gene cluster previously ass

254 hymic lymphomas with t(12;14) translocation, syntenic to inv(14;14) in humans.

255 m of rice chromosome 3, which is known to be syntenic to long arms of group-4 chromosomes of wheat.

256 Human loci that are syntenic to many of the insulin secretion QTL from mouse

257 We also noted that PUL1,6-beta-glucan is syntenic to many PULs from other Bacteroidetes, suggesti

258 e of linkage to BMD phenotypes in the region syntenic to our linkage finding on chromosome 1q.

259 ity to each other in aligned regions and are syntenic to phage BcepNazgul.

260 These loci are syntenic to regions on human chromosomes 17q and 5q impl

261 CD8+ T cells, and genetic linkage to disease syntenic to that found in humans.

262 a chromosomal deficiency spanning a segment syntenic to the human 22q11.2 locus.

263 lyrata p4-siRNA hot spots are generally not syntenic to the most active p4-siRNA hot spots of A. tha

264 the human genome that occur near the region syntenic to the mouse enhancer exhibit significant assoc

265 /lpr mice, with trans-repression of a region syntenic to the murine CD8b promoter.

266 ith a duplication of a 2-Mb genomic interval syntenic to the PTLS region and identified consistent be

267 a 12.67-Mb interval (8q21.13-q22.1) that is syntenic to the Wpk locus in rat, which is a model with

268 Although human piRNA genes are syntenic to those in other placental mammals, their sequ

269 amplifications and deletions targeting loci syntenic to those not only in human T-ALL but also in di

270 quired copy number gains and losses that are syntenic to those observed in human MYCN-amplified NBL i

271 c regions on human chromosome 21 (Hsa21) are syntenic to three regions in the mouse genome, located o

272 nimal genomes, we found the previously known syntenic UCEs as well as previously undescribed nonsynte

273 a region of canine chromosome CFA15 that is syntenic with a region of human chromosome 14 (HSA14q11.

274 This amplicon is syntenic with a similar chromosome 11q22 amplicon identi

275 in lies in a 4-Mb region of Ab10 that is not syntenic with any other region of the maize genome and s

276 acteria such as transposases and integrases) syntenic with ARGs were rare in soil by comparison with

277 A. carolinensis microchromosomes are highly syntenic with chicken microchromosomes, yet do not exhib

278 porting the conclusion that the two loci are syntenic with conservation of function.

279 The M. truncatula region is syntenic with duplicated regions of Arabidopsis chromoso

280 ly copy number gains at mouse chromosome 11, syntenic with gains on human chromosome 17q.

281 s to canine chromosome 9 (CFA9), in a region syntenic with gene-dense human chromosome 17q.

282 1 amplifications and chromosome 4 deletions, syntenic with human 17q21-25 and 1p35-36, respectively.

283 to a 0.44 Mb interval of mouse chromosome 1 syntenic with human 1q23.2.

284 d of mouse chromosome 17 in a region that is syntenic with human chromosome 21q22.3, where the gene f

285 e trac mutation maps to mouse chromosome 17, syntenic with human chromosome 2p21-22.

286 This mouse QTL is syntenic with human chromosome 9p.

287 Several of the loci identified were syntenic with human T2D-related loci, indicating that th

288 tion in the H. rubra mitochondrial genome is syntenic with most malacostracans that have been examine

289 nsposable elements and are less likely to be syntenic with orthologous genes in other grasses.

290 several growth factor proteins, and regions syntenic with pearl millet or maize genomic regions that

291 This region is syntenic with previously identified blood pressure-relat

292 ost interestingly, AID induces DSBs at sites syntenic with sites of translocations, deletions, and am

293 al of 64% and 66% of Ae. tauschii genes were syntenic with sorghum and rice genes, respectively.

294 The genomes were syntenic with that of the murids Mus musculus and Rattus

295 The chl gene is on a region of chromosome 21 syntenic with the area of murine chromosome 7 bearing th

296 ied a locus on chromosome 14 (34.5-41.4 Mb), syntenic with the human 10q22-q23 schizophrenia-suscepti

297 at the IFITM locus exists in chickens and is syntenic with the IFITM locus in mammals.

298 that 27 % of the 3B predicted genes are non-syntenic with the orthologous chromosomes of Brachypodiu

299 This gene order is syntenic with the vernalization1 locus responsible for f

300 hat shares high sequence similarity to a non-syntenic zebrafish analog, cat7l Defects caused by inter