ライフサイエンスコーパス: syntheses

1 t occurs between modulator and linker in MOF syntheses.

2 imulated diverse methods for their efficient syntheses.

3 rgy production and amino acid and nucleotide syntheses.

4 sed to predict organic(5) and inorganic(6,7) syntheses.

5 covering physical, chemical, and biological syntheses.

6 owed by a description of individual reported syntheses.

7 mechanical bonds formed via active-template syntheses.

8 ds obtained through demanding total chemical syntheses.

9 rgy production and amino acid and nucleotide syntheses.

10 ironmentally-benign and sustainable chemical syntheses.

11 mordenite crystals prepared via conventional syntheses.

12 hemical diagnostics, and microscale material syntheses.

13 , which compares favorably with all previous syntheses.

14 an be generalized in other metallic nanowire syntheses.

15 surrogate for other well-established alkyne syntheses.

16 n the basis of the catalysts employed in the syntheses.

17 c labeling, have not been considered in past syntheses.

18 a single operation, leading to concise total syntheses.

19 le these NPs for application in biocatalytic syntheses.

20 d ring systems, in agreement with literature syntheses.

21 ucleotides during leading and lagging strand syntheses.

22 g reactions in pharmaceutical and laboratory syntheses.

23 oxane formation, a common problem in silanol syntheses.

24 ted via multiple, individual block copolymer syntheses.

25 In 9 prior total syntheses, 11-34 steps (LLS) were required.

26 ared through multistep chemical or enzymatic syntheses(4,5).

27 e development of more highly step-economical syntheses, a synthesis that combines high levels of step

28 ill gain wide acceptance for PET radiotracer syntheses across the radiochemistry community.

29 Here we present the syntheses, activities, and crystal structures of the p53

30 Altogether, organic syntheses, activity-based protein profiling, yeast mutag

31 power-law model for the frequency of repeat syntheses and assess the validity of this model using a

32 Here we report, in full, the syntheses and conformational properties of three out of

33 d in regulation of cholesterol and terpenoid syntheses and down-regulated those involved in glyceroph

34 In this review, the syntheses and electronic structures of the geminal diani

35 ough widely used in catalysis, the multistep syntheses and high loadings typically employed are limit

36 resource for earth sciences, climate change syntheses and model evaluation.

37 It includes syntheses and multiple mechanisms of degradations of the

38 The syntheses and O(2) reactivities of active-site models of

39 Syntheses and optimization processes to mitigate this gr

40 The syntheses and optoelectronic properties of two different

41 s or protecting groups need complex chemical syntheses and require UV, visible, or two-photon NIR lig

42 The progress in nanocrystal syntheses and surface engineering has opened the way to

43 Herein, we report the syntheses and use of three peptide mimics as potential s

44 es that are long-known, but studies on their syntheses and uses are rare.

45 hat Bronsted bases play in amide-assisted NP syntheses and were necessary for Ge incorporation.

46 Typical preparations involve multistep syntheses and/or macroinitiator approaches.

47 nable excitation and emission profiles, mild syntheses, and biological compatibility.

48 idal particles is ubiquitous in many zeolite syntheses, and has led to extensive efforts to understan

49 Herein, we demonstrate the design, syntheses, and molecular architectonics of cyclic dipept

50 nd folds, novel chemical approaches to their syntheses, and their value as pharmacological tools to u

51 fferent effects on growth and macromolecular syntheses, and they phosphorylate distinct substrates.

52 zole (BTD) core was used as the base for the syntheses, and two pai-extended fluorescent derivatives

53 low evaluation of covariation in cross-study syntheses, and we recommend against using Hedges' g in b

54 a set of precursors needed for macromolecule syntheses; and (2) enzymes in each subnetwork have chara

55 The syntheses are amenable to large scale manufacturing.

56 The syntheses are captured as digital code that can be publi

57 ted, but systematic reviews and quantitative syntheses are lacking.

58 However, their chemical syntheses are often long, complex, and not easily amenab

59 oniae, septal and longitudinal peptidoglycan syntheses are performed by independent functional comple

60 Several syntheses are presented that demonstrate the broad funct

61 lity for the intelligent scale-up of organic syntheses, as demonstrated in the present study by the s

62 Their syntheses benefit from decades of research but are often

63 alkali-metal-sulfur batteries, organic syntheses, biological chemistry, geochemical processes i

64 xperimental design, drug discovery, chemical syntheses, business intelligence, and historical studies

65 e alternatives to traditional solution-based syntheses, but they have also received attention for the

66 be introduced into COFs directly via de novo syntheses can be accessed through post-synthetic modific

67 The syntheses can be carried out at room temperature because

68 -then highly efficient, scalable and modular syntheses can result.

69 nto DNA-encoded libraries (DELs) because DEL syntheses cannot fully exploit the capabilities of moder

70 form the natural product skeleton, with the syntheses completed in just one further operation.

71 disciplines, due to their challenging total syntheses, complex biosynthesis pathways, mechanism of a

72 Data were extracted and narrative syntheses conducted.

73 nizing center for peptidoglycan and membrane syntheses critical for cell envelope formation during po

74 We provide full detailed syntheses, describe its cocrystallization with and behav

75 according element combinations or bottom-up syntheses employing low valent organo-main group element

76 These syntheses enabled the unambiguous characterization of th

77 These syntheses feature an asymmetric decarboxylative allylati

78 Both syntheses follow a convergent approach that unites the C

79 specialists, to work towards better evidence syntheses for better evidence and better decisions.

80 Following specific examples of syntheses for monometallic, multimetallic, and heterostr

81 s for the directed design of electrochemical syntheses for Pd cubes and octahedra.

82 Improved syntheses for the large-scale preparation of both compou

83 We report syntheses for two families of heterogeneous-atom-incorpo

84 this Review, we highlight ten selected total syntheses from 2014 to 2019 that illustrate how transiti

85 the scorpion venom, we developed laboratory syntheses from commercially available precursors, allowi

86 n in concert with varied alpha-hydroxyketone syntheses, giving access to a broad spectrum of alkynes.

87 ms to computationally plan multistep organic syntheses has been a challenge for more than 50 years(1-

88 Despite their interest, relatively few total syntheses have been completed.

89 scoveries, robust di- and triblock copolymer syntheses have been demonstrated with olefins (ethylene

90 o any cultivated organism, >70-step chemical syntheses have been developed to access these unique com

91 elative to combinatorial design of colloidal syntheses have the potential to accelerate the synthetic

92 tion in methodologies preventing cross-study syntheses, how PCBs biomagnify at food web, regional, an

93 The qualitative syntheses identified 15 operational considerations acros

94 ures that are difficult to form by bottom-up syntheses in a controlled fashion.

95 This means that the connection of multi-step syntheses in a single machine to run many different prot

96 aration impact the full spectrum of chemical syntheses in academia and industry.

97 including strategies investigated for their syntheses in the literature, the conformations adopted b

98 ontext of more than 70 natural product total syntheses in which the reactions served as a key strateg

99 Key features of the syntheses include an acid-catalyzed tandem intermolecula

100 in the year 2000 prompted numerous chemical syntheses, including scalable preparations with as few a

101 The key step in these syntheses involve a Rh-catalyzed C-C/C-H activation casc

102 roperties unachievable via conventional bulk syntheses is envisioned.

103 e time of Charles Darwin, but several recent syntheses link earthworm activities to higher greenhouse

104 e through N-nucleotide addition, with longer syntheses manifesting as N-regions.

105 Focused libraries based on these syntheses may exclude the NP but maintain the molecular

106 Cross-study syntheses may inflate these influences by collating stud

107 deal levels of resource economy in molecular syntheses, novel avenues are required, which include, bu

108 zation strategy opens new avenues for facile syntheses of "designer materials" where chemical compone

109 The concise and convergent total syntheses of (+)- and (-)-Fumimycin have been achieved b

110 stituent choice, leading to enantioselective syntheses of (+)-chelidonine, (+)-norchelidonine, and (+

111 , respectively, en route to highly efficient syntheses of (+)-limaspermidine and (+)-kopsihainanine A

112 The first total syntheses of (+/-)-rhabdastrellic acid A and (+/-)-stell

113 This led to concise syntheses of (-)-akuammicine and (-)-strychnine.

114 The total syntheses of (-)-herquline B (2) and a heretofore-unreco

115 ategy was utilized in enantioselective total syntheses of (-)-macfarlandin C and (+)-dendrillolide A.

116 Herein, the first total syntheses of (-)-pseudocopsinine (1) and (-)-minovincine

117 The asymmetric total syntheses of (-)-rhynchophylline and (+)-isorhynchophyll

118 The asymmetric syntheses of (-)-strychnopivotine and the polycyclic mai

119 hase-transfer catalyst, the first asymmetric syntheses of 1-oxaspiro[2.5]octa-5,7-dien-4-ones were re

120 We showcase automated syntheses of 12 compounds from the literature, including

121 action parameters applied for the successful syntheses of 12-, 13-, and 14-membered natural product C

122 We report the syntheses of 2 and its congener deacetylakuammiline (3).

123 Rapid syntheses of 5-HT2C agonist, (-)-enduracididine and azid

124 We report herein the syntheses of 79 derivatives of the 4(3H)-quinazolinones

125 Two practical and high-yielding syntheses of 9-phosphatriptycene are reported.

126 Syntheses of a crystalline polycyclic halichondrin C1-C1

127 In this study, the syntheses of a range of hongoquercins using gold-catalyz

128 ropisomers herein have allowed the practical syntheses of a small nanographene as well as some tripty

129 on strategy was demonstrated in the scalable syntheses of a variety of complex molecules carrying sul

130 utes to biotic targets, as well as plausible syntheses of abiotic molecules.

131 ctive oxidations of porphyrins, the rational syntheses of all five dilactone isomers along stepwise,

132 given the limited number of enantioselective syntheses of alpha-tertiary amines.

133 However, prior syntheses of ambient stable, open-shell molecules requir

134 , in comparison with the previously reported syntheses of aminooxazoles based on gold-catalyzed nitre

135 Syntheses of analytical standards, including deuterium-l

136 s inability to catalyze transapiosylation in syntheses of apiosides.

137 The syntheses of beta-S-GlcA(1->3)GlcNAc and beta-S-Gal(1->3

138 lopments, as well as the applications in the syntheses of bioactive compounds and polymers.

139 n provides a breakthrough towards developing syntheses of biomimetic iron-sulfur-carbide clusters lik

140 of RO 20-1724 as well as in the formal total syntheses of both (+/-)-hamacanthin B and (+/-)-quinagol

141 The syntheses of both compounds were dependent on functional

142 Here we report the syntheses of both natural and unnatural dibenzylbutane l

143 utative biogenetic precursor, from which the syntheses of both natural products were attempted.

144 All prior syntheses of brazilin have involved a Friedel-Crafts alk

145 Whereas nine total syntheses of bryostatins have been achieved to date, bry

146 The total syntheses of caesalpinnone A (1) and its putative biosyn

147 Syntheses of carbonate chemistry spatial patterns are im

148 portend that this process will expedite the syntheses of chiral heterocyclic amines of significance

149 nces in these areas, including collaborative syntheses of chlorolissoclimide, nigelladine A, artemisi

150 ted in a gram-scale reaction and streamlined syntheses of complex ether, sulfone, and tertiary amine

151 We have also applied it in the formal total syntheses of complex molecules.

152 th scaffold, the piperidinoindoline, through syntheses of compounds now termed "dihydropsychotriadine

153 e reaction intermediates in high temperature syntheses of copper nanocrystals by a variety of techniq

154 of this process is highlighted in multigram syntheses of d- or l-nucleoside analogs, locked nucleic

155 pled with our previously developed templated syntheses of dibenzo crown ethers, this protocol makes p

156 tion-phase and the high-yielding solid-phase syntheses of discrete oligourethanes and methods for the

157 The method is demonstrated in the successful syntheses of eighty-eight otherwise difficult to access

158 The four generations of the total syntheses of ent-oxycodone were accomplished in 13, 18,

159 The one-step syntheses of exotine A and exotine B, which comprise the

160 Total syntheses of five naturally occurring polyacetylenes fro

161 e is the shortest among >30 total and formal syntheses of fostriecin family members.

162 ed strategy toward the stereoselective total syntheses of halimene-type terpenoids and analogues as a

163 t glycosylation strategy for achieving rapid syntheses of heptose (Hep)-containing oligosaccharides.

164 An approach for the syntheses of herqulines B and C is reported that takes a

165 are discussed in the context of eight recent syntheses of hetidine and hetisine natural products and

166 Enantioselective syntheses of hexacyclic aspidoalbidine alkaloids (+)-fen

167 odology has been successfully applied to the syntheses of hitherto unreported imidazo-fused benzimida

168 Reported syntheses of hydrophobic MOFs are critically summarized,

169 ooperative catalysis, here we report concise syntheses of indenone-based natural products, paucifloro

170 Although these methods have gained success, syntheses of isotope-labeled peptides are time-consuming

171 pH levels relevant to experimental prebiotic syntheses of key biomolecules is a compelling reason to

172 Short and scalable total syntheses of lamellarin G trimethyl ether, lamellarin D

173 Syntheses of large polycyclic aromatic hydrocarbons (PAH

174 taining up to six-membered heterocycles; the syntheses of larger rings failed.

175 lenge of prebiotic chemistry is to trace the syntheses of life's key building blocks from a handful o

176 his newly developed method, enantioselective syntheses of lyconadins A-E (1-5), lycopecurine (6), and

177 ing macrocyclization handles and the one-pot syntheses of macromulticyclic peptide cages.

178 Herein, the total syntheses of malacidin A and its analogues are reported

179 As part of a program to develop practical syntheses of members of the family of (bacterio)chloroph

180 The first total syntheses of members of these natural product families a

181 (5)Br), can lead to concise asymmetric total syntheses of microcladallenes A and B, desepilaurallene,

182 ation of vinyl acetohydroxamates facilitated syntheses of monocyclic beta-lactams suitable for incorp

183 ivalent of the diarylborinic acid, selective syntheses of more complex monosulfated glycosides, namel

184 nts the limitations of traditional colloidal syntheses of nano-heterostructures with atomic precision

185 ccessfully validated three computer-designed syntheses of natural products in the laboratory.

186 a result linking new and existing laboratory syntheses of natural products with findings of the compo

187 plication of the tandem reaction sequence to syntheses of neonectrolides B-E as well as previously un

188 Here, we report molten-salt syntheses of NiO particles exposing a variety of crystal

189 has worked to solve this problem by devising syntheses of NP leads, diversifying late-stage intermedi

190 Chemical syntheses of oligosaccharides and glycosides call utiliz

191 We describe here the syntheses of optically pure (3aS,4S,7aR)-hexahydro-4H-fu

192 le may allow future development of catalytic syntheses of oxygenated products from CH(4) in gas-phase

193 quired to complete chemical and/or enzymatic syntheses of polysaccharides as long 92-mers.

194 Therefore, finding plausible prebiotic syntheses of potentially ancestral noncanonical nucleoti

195 re challenging processes, especially for the syntheses of primary amines, which often are non-selecti

196 cating that the intermediates of the de novo syntheses of purines and histidine, 5-aminoimidazole-4-c

197 trategy was demonstrated in the short formal syntheses of pyrrolidinoindoline alkaloids (+/-)-CPC-1 a

198 Although biomimetic total syntheses of representative compounds have been reported

199 utility is further demonstrated by the total syntheses of salinipyrones A and B.

200 e, yet efficient, scalable, and controllable syntheses of sequenced copolymers remain a defining chal

201 The exemplified syntheses of several biologically and clinically importa

202 these claims, computer-predicted, prebiotic syntheses of several biotic molecules as well as a multi

203 these concepts was illustrated by the total syntheses of several natural products and other importan

204 concise, divergent, and redox-economic total syntheses of several polycyclic members of the rhodonoid

205 The chemical syntheses of several variants, efficacy in reversing mul

206 Bioinspired total syntheses of six isolates were achieved in six steps uti

207 The expedient and stereoselective syntheses of small libraries of trifunctionalized cyclob

208 ble the rapid development of continuous-flow syntheses of small molecules in high yield.

209 tion of hemp candidate genes involved in the syntheses of specialized metabolites.

210 minotransferases to realize stereoconvergent syntheses of stereodefined gamma-substituted alcohols an

211 and dienophiles, which enables the expedient syntheses of structurally diverse natural products.

212 loit nonclassical crystallization routes for syntheses of structured and functional materials.

213 We describe enantioselective syntheses of strychnos and chelidonium alkaloids.

214 Combinatorial syntheses of such libraries require water- and DNA-compa

215 metal in the products, and is applicable to syntheses of targets in the pharmaceutical area.

216 Enantioselective total syntheses of the anticancer isocarbostyril alkaloids (+)

217 The syntheses of the benzo-bridged dioxa- and diazatriangule

218 The first syntheses of the cytotoxic peptides lipovelutibols B and

219 The syntheses of the enantiomers of two other closely relate

220 , B-P, and B-halide bonds is combined in the syntheses of the first diiododiborenes.

221 ch has focused on finding possible prebiotic syntheses of the four canonical nucleotides of coding RN

222 Concise enantioselective syntheses of the fragments were devised, with highlights

223 Unified, efficient, and scalable syntheses of the halichondrin natural products are repor

224 Divergent and enantiospecific total syntheses of the indolosesquiterpenoids xiamycins A, C,

225 Total syntheses of the monoterpenoid indole alkaloids (+/-)-al

226 ers, featuring divergent and stereoselective syntheses of the N-acetyl-8a-cyanodecahydroquinoline fra

227 nsformations of the products, as well as the syntheses of the natural product iso-moracin and the dru

228 escribed here are the collective and concise syntheses of the natural products (-)-microthecaline A,

229 Described herein are syntheses of the naturally occurring polyketides (-)-tet

230 ition, we showcase its utility by the formal syntheses of the pharmaceuticals NGB 4420 and tenilapine

231 e report a common strategy to facilitate the syntheses of the polycyclic alkaloids (-)-FR901483 (1) a

232 ily accessible starting materials, and short syntheses of the privileged scaffold indeno[1,2-c]isoqui

233 The first asymmetric total syntheses of the real isolation product (2S,5R,8R)-green

234 often provided concise and nonobvious total syntheses of the targeted natural products, typically we

235 Modular gram-scale syntheses of the trimethyl ethers of lamellarins G (6) a

236 tegy, we achieved the enantioselective total syntheses of the type A PPAPs (-)-nemorosone and (-)-6-e

237 ity of substrates allowed axially controlled syntheses of their trans-mono-alkylated derivatives, sub

238 ompelling mandate to develop practical total syntheses of these agents.

239 In addition, chemoenzymatic syntheses of these azaphilones supplied enantioenriched

240 al starting materials as opposed to previous syntheses of these ligands, which have confronted long a

241 on of pharmaceuticals, as highlighted by the syntheses of thiocarlide, butoxycaine, and pramoxine.

242 Conventional colloidal syntheses of this class of hybrid structures require com

243 Four syntheses of this compound have been reported, which are

244 In addition to new syntheses of three of the seven amino acid subunits, hig

245 Herein, the total syntheses of tiancimycins A and B, yangpumicin A, and a

246 Specifically, the first syntheses of trichoflectin, deflectin-1a, and lunatoic a

247 here the diastereocontrolled formal racemic syntheses of tricyclic marine alkaloids, lepadiformines

248 strategy is amenable to the stereocontrolled syntheses of trisaccharide diastereomers, and a tetrasac

249 As in our previous syntheses of trisaccharide repeating units, the potentia

250 We report the total syntheses of two indole diterpenoid natural products, pa

251 We demonstrate the syntheses of two magic methyl substrates-an inverse agon

252 reaction proved critical in achieving total syntheses of two oxygenated natural products, one of whi

253 This study details syntheses of unsymmetrical magnesium(I)-adduct complexes

254 en limited to relatively simple targets, the syntheses of which could arguably be designed by human c

255 from a common intermediate enabled the first syntheses of xiamycins C and F, and an unexpected one-po

256 We expect that these OSDAs will lead to syntheses of zeolite beta.

257 were included in qualitative or quantitative syntheses, of which only three were of moderate-to-high

258 g meta-ethnography, was used for qualitative syntheses on operational considerations encompassing acc

259 polycyclizations applied to natural product syntheses over the last five years are discussed, includ

260 In both of these syntheses, Parker's cyclization was employed to construc

261 ugh ubiquitous to colloidal nanocrystal (NC) syntheses, play a role in assembling NCs into higher ord

262 ormation and that the metals involved in the syntheses (potassium in the case of the trifluoromethyl

263 However, syntheses pursuing precisely targeted mixed functionalit

264 acrocycles raises the importance of stepwise syntheses relative to one-pot macrocyclizations to offer

265 nes have been reported, but their concurrent syntheses remain a challenge.

266 The syntheses require 14 and 13 steps, respectively, and fea

267 eactions, metathesis processes, heterocycles syntheses, S(E)Ar reactions, metalation-ring opening seq

268 bimetallic catalysis for sustainable organic syntheses (SOS), highlighting key advances and represent

269 hemists to explore and select more efficient syntheses/synthetic routes.

270 Syntheses tend to employ only a single OSDA, but there a

271 in practice, resulting in the publication of syntheses that are highly susceptible to bias.

272 However, the scarcity of global syntheses that consider long-term processes has limited

273 of these approaches, with an emphasis on the syntheses that employ soluble Zintl anion compounds.

274 results also hint that there are many repeat syntheses that have been performed but not reported in t

275 this review, we survey a selection of recent syntheses that have implemented carbanion- or radical-ba

276 this Review, we survey a selection of recent syntheses that have implemented carbanion- or radical-ba

277 as TiO(2) for promoting challenging organic syntheses that rely on highly reactive intermediates.

278 method does not depend on lengthy precursor syntheses, the separation of isomers, or impractical lim

279 hat book reviews function as a form of short syntheses to inform and guide readers in deciding to use

280 igand design circumvents the extended linear syntheses typical of bifunctional catalysts, enabling sy

281 at have allowed us to deliver cost-effective syntheses under reduced timelines in an increasingly com

282 halides (Ar-X; X = I, Br, Cl) toward biaryl syntheses underwent smoothly in the presence of only 10

283 the context of resource economy in molecular syntheses until February 2020.

284 The modular motif affords efficient syntheses using building blocks optimized for interactio

285 e opportunities and limitations of enzymatic syntheses using distinct examples and provides an outloo

286 after the recent success of large-scale BNNT syntheses using high-temperature-pressure laser ablation

287 tudents evaluated the outcome of a series of syntheses using spectra corresponding to the products.

288 publish rigorous and comprehensive evidence syntheses, we aim here to identify major pitfalls in the

289 Using the latest simulations and data syntheses, we find agreement for spectra derived from ob

290 Both mitochondrial RNA and DNA syntheses were affected by rnh1 knockdown, suggesting th

291 Finally, measurements of colloidal syntheses were employed as guides for the directed desig

292 Both syntheses were performed by a peptide synthesizer in a s

293 acic Society.Methods: Comprehensive evidence syntheses were performed on all relevant studies that ad

294 The syntheses, which commence from (R)-carvone, employ a key

295 ly specialized laboratories can perform such syntheses, which greatly hampers progress in glycoscienc

296 known about the reaction mechanisms of their syntheses, which has hampered the development of new rea

297 e desired analogues that required multi-step syntheses with classical methods.

298 low cell design that make possible selective syntheses with high conversion of reactant to product wi

299 of metallabenzenes and it may be viable for syntheses with suitable ligands.

300 The one-step syntheses, X-ray structures, and spectroscopic character