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1 nsferase genes involved in exopolysaccharide synthesis.
2 ators after they are incorporated during RNA synthesis.
3 GAT1) are already known to be related to oil synthesis.
4 correlated with genes involvement in oxalate synthesis.
5 roles in regulating fragile X protein (FMRP) synthesis.
6 ation initiation and reducing global protein synthesis.
7 analog widely employed in studies of protein synthesis.
8 rug discovery programmes and natural product synthesis.
9 ding to PHGDH degradation to suppress serine synthesis.
10 te shift likely has little effect on protein synthesis.
11 could be connected to C. neoformans melanin synthesis.
12 ure more efficient and practical for organic synthesis.
13 ELOVL2 (Elovl2(-/-) ), the key enzyme in DHA synthesis.
14 tors) and regulates crucial steps in protein synthesis.
15 ansformations in the field of modern organic synthesis.
16 to stationary phase, tone down their protein synthesis.
17 s provides a continual challenge to chemical synthesis.
18 regulate hepatic acetyl-CoA and cholesterol synthesis.
19 nfection, which was reversed by blocking LOS synthesis.
20 an essential amino acid required for protein synthesis.
21 and unnatural-amino-acid-containing protein synthesis.
22 rapid cell elongation to secondary cell wall synthesis.
23 rised by reduced or absent beta-globin chain synthesis.
24 rch for exoplanets(14,15), optical frequency synthesis(16), time keeping(17) and other areas(10).
25 6 genes were found to be associated with oil synthesis (27 genes), amino acid synthesis (four genes)
26 we isolated multiple genes impacting protein synthesis: a ribosomal RNA helicase gene, tRNA biosynthe
28 the basis of this detection, our population synthesis analysis implies that such asymmetric binaries
31 tion risk during the colder periods when AMP synthesis and bacterial growth is slow and pathogen pres
32 cyltransferase (LRAT) disrupt 11-cis-retinal synthesis and cause Leber congenital amaurosis (LCA).
34 c acid and non-nucleic acid targets, ease of synthesis and chemical modification, amenability to be i
36 g, and could be particularly relevant to the synthesis and cotranslational behavior of some proteins.
39 The contribution of each mechanism to cutin synthesis and deposition has shown a temporal and coordi
44 ted prolonged S-phase, were defective in DNA synthesis and had increased DNA damage levels, suggestin
45 d through a variety of substrates, including synthesis and late-stage functionalization of scaffolds
49 luding phosphatidylinositol-3,5-bisphosphate synthesis and retrograde transport from the vacuole.
50 his effect of mTORC1/2 inhibitors on protein synthesis and RRM2 levels was rescued in cell lines with
53 e characterized by elevated rates of protein synthesis and that high expression of ABCE1, a translati
54 ts into the processes that underpin osmolyte synthesis and transport, but the main computational appr
55 sponded differently to XRN1 deletion in mRNA synthesis and were differentially regulated by mRNA deca
57 se changes presumably lead to decreased 5-HT synthesis and/or increased 5-HT reuptake, thereby reduci
63 dology enables spatial regulation of protein synthesis, and deciphering, reconstruction and design of
64 of innovative tools, we examine the design, synthesis, and properties of light-activated degraders.
68 nstrate a promising application of BO in CNT synthesis as an efficient and robust algorithm which can
70 We perform a comprehensive analysis of DNA synthesis at all STR permutations and interrogate the im
71 ent cohesin removal is needed to restart DNA synthesis at stalled forks and promote survival followin
74 on is an important building block in organic synthesis because it features several reaction sites wit
75 y decreased 40S fraction and reduced protein synthesis but no major changes in m(2) (6,6)A levels in
76 were mechanistically independent of protein synthesis but sensitive to pharmacological blockade of t
78 ent plasma cells adapt to increased antibody synthesis by activating the unfolded protein response (U
79 tide addition, can stimulate translesion RNA synthesis by Escherichia coli RNAP without altering the
80 me assembly factor, RbfA, suppresses protein synthesis by immature Escherichia coli 30S subunits.
83 )F]DOPA uptake, an estimate of dopamine (DA) synthesis capacity, in the striatum predictive of conver
86 1, slo-1, or homt-1 (a gene required for Mel synthesis) causes substantially increased neurotransmitt
88 The ability to achieve chirality-selective synthesis (chiral induction) is of great importance in s
89 to previously unattainable measurements and synthesis conditions at unparalleled efficiencies and sa
90 substrate lickings) when presented with the synthesised cyclo(L-Pro-L-Pro) chemical blend, compared
91 a large set of single-cell E. coli flagellar synthesis data from different strains and mutants, we id
93 are ultimately responsible for the excessive synthesis, deposition and remodelling of extracellular m
94 pe reactions commonly applied for on-surface synthesis, distinct stepwise on-surface reactions, inclu
95 lational modification that regulates protein synthesis during cellular response to oxidative stress.
97 , the rate-limiting substrate for fatty acid synthesis (FAS), is produced in the soma and delivered t
99 eotide was in the first coding position, DNA synthesis fidelity was similar to that observed with a 1
100 ed with oil synthesis (27 genes), amino acid synthesis (four genes) and the tricarboxylic acid (TCA)
104 sins (ebh, sdrD), polysaccharide and capsule synthesis genes, cell wall remodeling genes (lytN, ddh),
106 and society, and recent improvements in DNA synthesis have enabled the manipulation of megabase geno
107 tially valuable building blocks for chemical synthesis, have each been prepared from cyclopentanone i
110 strate the feasibility of perturbing protein synthesis in a mouse liver by targeting translation elon
112 r cells require nominal increases in protein synthesis in order to maintain high proliferation rates.
119 We propose that Myc-regulated fatty acid synthesis is a valid target for therapy and/or preventio
121 in machines extract these lipids after their synthesis is completed at the inner membrane and transpo
126 ish revealed that neutrophil chemoattractant synthesis is triggered by a sustained calcium flux upon
127 l erythritol phosphate pathway of isoprenoid synthesis, is essential for Gram-negative bacteria, myco
128 is the ability of a gene to repress its own synthesis, is the most abundant regulatory motif known t
130 motifs, control experiments, and gram-scale synthesis make the synthetic model viable and significan
131 rminal differentiation (FLG and FLG2), lipid synthesis/metabolism (ELOVL3 and FA2H), and tight juncti
133 uate the response of skeletal muscle protein synthesis (MPS) to anabolic stimuli such as protein inge
135 t reorganize its catalytic center to promote synthesis of 2'-5'-oligoadenylate and thus activation of
137 on has a broad scope, as demonstrated by the synthesis of 35 different ketones bearing a wide variety
142 ic DNA transcription templates regulates the synthesis of a fluorescence-activating RNA aptamer.
144 of this method has been demonstrated in the synthesis of acylsilanes bearing different silyl groups
145 environment was exploited to accomplish the synthesis of alkenes using a one-pot, two-step experimen
147 ) catalyzed the direct or one-pot sequential synthesis of alpha,alpha-disubstituted ketones via the a
151 -pot, metal-free, double cyclization for the synthesis of bicyclic 2-pyridones as peptidomimetics was
154 s at fully substituted carbon centers in the synthesis of chiral 2,2-disubstituted benzomorpholines.
155 iated methodology has been developed for the synthesis of chiral 2-aryl-ferroceneamides from chiral 2
156 products are suitable intermediates for the synthesis of chiral vicinal diamines as has been verifie
157 and can be employed to achieve the targeted synthesis of clinically-relevant molecules in the presen
158 tudy reveals an alternative sequence for the synthesis of compounds that contain the pyrrolodiketopip
160 rganozinc reagents, thereby allowing for the synthesis of cyclic and acyclic tetrasubstituted double
162 s highlight the utility of the method in the synthesis of densely functionalized small molecules suit
169 sed as an initiator, was tracked through the synthesis of Glu-PLGA by both (13)C NMR and enzymatic an
170 in organic solvent as well as the enzymatic synthesis of glycan epitopes in the aqueous phase in a s
172 alyzes the rate-limiting step in the de novo synthesis of guanine nucleotides, impacting the cellular
173 Herein, we describe an expeditious total synthesis of hemiasterlin featuring a four-component Ugi
176 nditions and broad scope, and allows for the synthesis of highly functionalized azetidines from readi
178 otensin system (RAS), including the balanced synthesis of its main effector peptides Ang (angiotensin
179 supplementation, indicating that endogenous synthesis of LA is essential for C. elegans development.
180 is a unified click-approach for the modular synthesis of lead-like structures through application of
182 identify a pre-emptive pathway that reduces synthesis of membrane proteins that have failed to prope
187 ld open new possibilities for the design and synthesis of molecular cages with novel topologies targe
190 ecent methodological study investigating the synthesis of N-alkoxyazomethine ylides, an unexpected am
191 h-throughput, printing-technology-compatible synthesis of nanocrystalline particles of common materia
192 tive bottom-up approach for the non-covalent synthesis of nascent axial organic heterostructures, whi
196 monoesters to diesters may have enabled the synthesis of nucleic acids, perhaps opening a way into t
197 start with a brief primer on the biological synthesis of nucleotides, followed by an extensive focus
200 ized silica resin to facilitate the chemical synthesis of peptides in organic solvent as well as the
201 lic acid-phosphoric acid anhydrides, for the synthesis of peptidyl-RNAs, peptides, RNA oligomers and
202 involving lipid metabolism, specifically the synthesis of pigments and oxylipins, and the metabolism
203 be derivatization via direct metalation, but synthesis of polysubstituted thiophenes bearing reactive
204 represents a new and powerful method for the synthesis of porous solids with tailored functionalities
206 omical and scalable route for the controlled synthesis of Pt-based intermetallic catalysts, which can
210 d coordination (ACC) strategy to achieve the synthesis of rare-earth single erbium (Er) atoms support
211 the components of nucleotides-either via the synthesis of ribose and the canonical nucleobases and th
215 observation was additionally verified by the synthesis of stable CO and 2,6-xylylisocyanide (XylNC) a
216 rk, a novel strategy for the straightforward synthesis of substituted phthalimides is described, whic
217 In this article, a high-yield method for the synthesis of sulfonyl 9-fluorenylidenes is described, wh
218 ere we report a strategy that simplifies the synthesis of terpenes by inverting the order of nature's
219 in the most brief and highest yielding total synthesis of the alkaloid in three steps and a 36% overa
220 esis uses key intermediates in the prebiotic synthesis of the canonical pyrimidine ribonucleosides (c
223 scientific statement provides an up-to-date synthesis of the existing data on the MT and how it rela
226 the predominant pathways responsible for the synthesis of the most abundant phospholipids, phosphatid
227 ycosyltransferase activities involved in the synthesis of the N-glycan of the viral major capsid prot
229 ated, the pyrimidines persist throughout the synthesis of the purine deoxyribonucleosides, leading to
230 o-, regio- and furanosyl-selective prebiotic synthesis of the purine deoxyribonucleosides: deoxyadeno
231 pairment, warranting a timely evaluation and synthesis of the scientific literature and formulation o
232 E-6-PHOSPHATE SYNTHASE1 (TPS1) catalyzes the synthesis of the sucrose-signaling metabolite trehalose
233 te their hydrological significance, a global synthesis of their effects on hydrology is lacking.
236 nimide removal by Pd(II) was applied for the synthesis of two ubiquitin activity-based probes (Ub-ABP
237 g the electrodeposition conditions can allow synthesis of unlimited combinations of ligand nano-seque
238 products and drug molecules, stereospecific synthesis of useful alpha-chiral alkyl amines, and rapid
239 the current strategy may be suitable for the synthesis of various complex natural and unnatural cyclo
244 d with inhibitors that prevent peptidoglycan synthesis or peptidoglycan crosslinking by penicillin-bi
245 orted molecular imaging measures of dopamine synthesis or release capacities, dopamine D(2/3) recepto
247 ression of genes involved in the cholesterol synthesis pathway in primary human T-ALL specimens.
249 ally in chemical biology for peptide/protein synthesis, posttranslational modifications, and DNA labe
250 The label-free and sensitive detection of synthesis products from single microbial cells remains t
255 For a deeper understanding of the levan synthesis reaction, we determined the crystallographic s
256 ion facilitates the increase in nucleic acid synthesis required for anabolic cell growth and prolifer
257 o demonstrate that cytokinin-induced protein synthesis requires isoforms of the ribosomal protein L4
258 olvents commonly used in polymer and peptide synthesis results in the alteration of DNA helical struc
259 g DNA replication, transcription, nucleotide synthesis, ribosome biogenesis and function, as well as
261 single, systemic dose of methotrexate, a DNA-synthesis (S phase) inhibitor, has been used since 1991
262 bility in compositional tuning and immediate synthesis scalability of high-Ni NMA very similar to NCA
263 )T(M) recall response because of expeditious synthesis/secretion kinetics (CCL3/4/5) and low activati
264 ress made in the field of small fluorocarbon synthesis since their invention in the early 1930s by Th
269 viding a framework for the design of new DEL synthesis technologies to enable next-generation drug di
270 ta and also allows for future sequencing and synthesis technologies, by changing the parameters of th
271 that we describe, depending on the metal and synthesis temperature used, as random (Co, Cd, 120 degre
273 ural analyses of replicative and translesion synthesis (TLS) DNA polymerases (Pols) are retained in t
274 the germline; there it is used in fatty acid synthesis to critically support embryonic development.
275 e and robust body of literature suitable for synthesis to detect macroimmunology patterns and effect
276 ioinformatic algorithms followed by chemical synthesis to predict and then produce small molecules in
279 sule polymerase Cps1B of App1 as an in vitro synthesis tool and an alternative for capsule polymer pr
280 ernative that can potentially enable ammonia synthesis under milder conditions in small-scale, distri
282 for individual SHs are scarce because probe synthesis usually takes place by time-consuming solution
283 translational machinery to slow down protein synthesis via phosphorylation of the eukaryotic initiati
284 The partial reduction of ECm during RNA synthesis was circumvented by the protection of the nitr
286 or HDAC3/6-selective HDACi, and new protein synthesis was not required for gene suppression by HDACi
288 drogenase, an enzyme required for 15-Oxo-ETE synthesis, was predominantly expressed in mast cells and
290 d in DNA packaging, replication, and protein synthesis were detected at lower rates and zinc finger f
291 While ribosome biogenesis and global protein synthesis were unaffected by nsun-1 depletion, translati
292 ficial larynx sound source, a vowel sound is synthesised which compares favourably with vowels of mod
293 h the natural A, T, G and C bases during DNA synthesis, which allows for labeling of replicating or r
294 egulation of genes responsible for cell wall synthesis, which contributes to fibre length by modulati
295 e is limited, EpdSCs activate de novo serine synthesis, which in turn stimulates alpha-ketoglutarate-
296 s associated with increased rates of protein synthesis, which lead to growth inhibition and hypersens
297 been proven as a powerful tool in asymmetric synthesis, while flow chemistry has begun its rise as a