ライフサイエンスコーパス: synthesis inhibition

1 imental and therapeutic possibilities for HA synthesis inhibition.

2 use of blockers of ET-1 receptors and by NO synthesis inhibition.

3 duction of calreticulin mRNA resists protein synthesis inhibition.

4 culture and that did not increase during DNA synthesis inhibition.

5 We report here that 4-MUG contributes to HA synthesis inhibition.

6 onditions of nutrient deprivation or protein synthesis inhibition.

7 smaller effect on nrd expression during DNA synthesis inhibition.

8 ry were similar to those produced by protein synthesis inhibition.

9 partial agonist activity as measured by DNA synthesis inhibition.

10 hormones, developmental signals, and protein synthesis inhibition.

11 observed appeared to be a consequence of DNA synthesis inhibition.

12 ives with increased potencies toward protein synthesis inhibition.

13 r, and is impaired by post-retrieval protein synthesis inhibition.

14 pite succumbing to the same level of protein synthesis inhibition.

15 and hypertension in response to nitric oxide synthesis inhibition.

16 nvolved recovery from stress-induced protein synthesis inhibition.

17 uggest the presence of ER stress and protein synthesis inhibition.

18 cludes eIF2alpha phosphorylation and protein synthesis inhibition.

19 it down recapitulates the effects of protein synthesis inhibition.

20 nous mRNAs, leading to a strong host protein synthesis inhibition.

21 cell monolayers from ricin-mediated protein synthesis inhibition.

22 synthesis without an effect on host protein synthesis inhibition.

23 e from mechanisms unrelated to prostaglandin synthesis inhibition.

24 M breakdown, were ruled out as causes of RNA synthesis inhibition.

25 gardless of MHV-induced general host protein synthesis inhibition.

26 -6, during virus-induced severe host protein synthesis inhibition.

27 showed increased sensitivity to sphingolipid synthesis inhibition.

28 ring sustained hyperemia is unaffected by NO synthesis inhibition.

29 lcholine were not attenuated by nitric oxide synthesis inhibition.

30 of exercise, and this was not changed by NO synthesis inhibition.

31 induced COX-2 independently of prostaglandin synthesis inhibition.

32 Parallel to RNA synthesis inhibition, 8-Cl-Ado was maximally incorporate

33 del of high serum Ang II) or by nitric oxide synthesis inhibition (a model of low serum Ang II).

34 Moreover, protein synthesis inhibition, a feature of the high-altitude pla

35 ng hypothermia as the only cause for protein synthesis inhibition (active, 0.47 +/- 0.08 pmol/mg prot

36 e mature protein) that had identical protein synthesis inhibition activity as compared to native BD1.

37 BD1-G28-5 sFv retained the full protein synthesis inhibition activity of recombinant BD1 and spe

38 nists or postsynaptic 2-arachidonoylglycerol synthesis inhibition again reversed this block.

39 sor and renal vasoconstrictor response to NO synthesis inhibition, although the natriuretic response

40 Differential aspects of DNA synthesis inhibition among cell types are presented and

41 all precursor lipids that leads to cell wall synthesis inhibition and (ii) membrane depolarisation th

42 ypoxic ROS and contributed to global protein synthesis inhibition and adaptive ATF4-mediated gene exp

43 Similarly, the protein synthesis inhibition and apoptosis induction correlated

44 in BCR-stimulated cells, leading to protein synthesis inhibition and cell cycle block.

45 8 or 249-265 lack functions of IFN-beta mRNA synthesis inhibition and degradation of PKR.

46 The dose responses for fatty acid synthesis inhibition and DNA synthesis inhibition are si

47 de the first evidence that placental protein synthesis inhibition and endoplasmic reticulum (ER) stre

48 lular pH and calcium manipulation on protein synthesis inhibition and energy failure due to anoxia/ag

49 olar macrophages with endogenous leukotriene synthesis inhibition and enhance this process in leukotr

50 factor alpha (TNF-alpha), the ability of RNA synthesis inhibition and NF-kappaB inactivation to sensi

51 Conversely, both AP synthesis inhibition and pharmacological antagonism redu

52 summarize recent findings about triglyceride synthesis inhibition and prevention of progressive disea

53 ases the apoptotic threshold through protein synthesis inhibition and simultaneous production of cera

54 lls from forodesine-induced RNA- and protein-synthesis inhibition and stabilized and increased Mcl-1

55 ecifically discuss their role in the protein synthesis inhibition and the intrinsic pathway of apopto

56 minals show decreased sensitivity to protein synthesis inhibition, and resistance coincides with a de

57 ells in nude mice treated with C75 showed FA synthesis inhibition, apoptosis, and inhibition of tumor

58 for fatty acid synthesis inhibition and DNA synthesis inhibition are similar.

59 on was correlated with the degree of protein synthesis inhibition as measured by autoradiography and

60 competed by an excess of IL-13 in a protein synthesis inhibition assay and confirmed by a clonogenic

61 neck cancer cells, as determined by protein synthesis inhibition assay and confirmed by clonogenic a

62 , resulting in nanomolar potencies in an ATP synthesis inhibition assay.

63 rom 12 to 50 microM in the cell-free protein synthesis inhibition assay.

64 )H-radiolabeled precursors in macromolecular synthesis inhibition assays against MRSA.

65 lls, as determined by clonogenic and protein synthesis inhibition assays.

66 This study reports the synthesis, inhibition assays against four human carbonic

67 Furthermore, sterol synthesis inhibition blocks Mga2 pathway activation.

68 tein genes occurs in a background of protein synthesis inhibition, but in the course of diapause, a s

69 3' --> 5' exonuclease may contribute to DNA synthesis inhibition by alkylating agents.

70 proposed model for the mechanism of protein synthesis inhibition by aminoglycosides that invokes a d

71 The mechanism of DNA synthesis inhibition by cerulenin is indirect, because e

72 Protein synthesis inhibition by cycloheximide (CHX) treatment in

73 ion by bisindolylmaleimide (BIM) and protein synthesis inhibition by cycloheximide (CX) on basal and

74 DF is selectively inactivated during protein synthesis inhibition by cycloheximide and at a late stag

75 gation of mesangial cell Fas, and by protein synthesis inhibition by cycloheximide.

76 Based on this model for protein synthesis inhibition by DB, and the proposed mechanism o

77 ic pathway activity and the magnitude of DNA synthesis inhibition by FAS inhibitors are increased in

78 The mechanism of protein synthesis inhibition by hypoxia and its circumvention by

79 We also found that hepatocyte DNA synthesis inhibition by IL-1beta was completely antagoni

80 The degree of DNA synthesis inhibition by myeloperoxidase-sufficient neutr

81 (-5) mol/L) was measured before and after NO synthesis inhibition by nitro-L-arginine (LNA, 10(-4) mo

82 Cholesterol synthesis inhibition can block HIV-TAT-mediated NLRP3 in

83 window, hours after training, where protein synthesis inhibition can cause amnesia.

84 t what injection time window(s) will protein synthesis inhibition cause spatial memory amnesia?

85 While Hsc70 completely reversed protein synthesis inhibition caused by Hg2+.

86 L-1 reproduced the induction of iNOS and DNA synthesis inhibition caused by TCT and endotoxin.

87 ts into the mode of action, drug uptake, DNA synthesis inhibition, cell cycle effects, and induction

88 Finally, we find that protein synthesis inhibition, cell-cycle arrest, protein kinase

89 revious studies have shown that nitric oxide synthesis inhibition corrects the hyporesponsiveness to

90 Brain cholesterol synthesis inhibition (CSI) at a young age in rats has be

91 Contrarily, PG synthesis inhibition decelerated or stopped directional

92 hat brief periods of global or local protein synthesis inhibition decrease the synaptic vesicles avai

93 transcriptional level, resulting in protein synthesis inhibition, decreased viral messenger RNA asso

94 Klf13 mRNA was resistant to de novo protein synthesis inhibition, demonstrating that Klf13 is a dire

95 correlate with TRAIL resistance, and protein synthesis inhibition did not sensitize the TRAIL-resista

96 increased biosynthetic activity, and protein synthesis inhibition downstream of mammalian target of r

97 reduction itself also attenuated the protein synthesis inhibition due to anoxia/aglycemia (to 55.6% o

98 measurements were made before and during NO synthesis inhibition during exercise.

99 r work supports the importance of coenzyme A synthesis- inhibition during infection, as well as the a

100 E-BP1 occurs roughly concurrent with protein synthesis inhibition; during recovery from heat shock re

101 Protein synthesis inhibition experiments confirmed the mechanism

102 alternative interpretations are that protein synthesis inhibition facilitates extinction and that pos

103 s, cases have been reported in which protein synthesis inhibition failed to affect memory consolidati

104 zation of the medium exacerbated the protein synthesis inhibition following anoxia/aglycemia, and sig

105 Moreover, protein synthesis inhibition following early FOS expression resu

106 Although protein synthesis inhibition has been shown to affect long-term

107 ecifically and highly cytotoxic [50% protein synthesis inhibition (IC50) ranging from >0.1 to 13 ng/m

108 neither postsession inactivation nor protein synthesis inhibition impaired context-appropriate respon

109 We show that protein synthesis inhibition impairs the SMN complex, revealing

110 ndent manner, to VEEV-induced macromolecular synthesis inhibition.IMPORTANCE Most previous research e

111 otein expression and was overcome by protein synthesis inhibition in 50% of the resistant cell lines.

112 ent, receptor-mediated and prolonged protein synthesis inhibition in CA1 pyramidal neurons.

113 fying, refined mechanism of RDV-mediated RNA synthesis inhibition in coronaviruses and define this nu

114 oduction, neither systemic nor unilateral E2 synthesis inhibition in NCM disrupted eventual song imit

115 host protein synthesis, whereas host protein synthesis inhibition in SARS-CoV-mt-infected cells was n

116 GSE treatment also showed DNA synthesis inhibition in starved and EGF-stimulated cells

117 Interestingly, inhibiting protein synthesis inhibition in the IL immediately after fear co

118 study was to examine the effects of protein synthesis inhibition in the intermediate cerebellum on t

119 ate the beneficial effects of thromboxane A2 synthesis inhibition in the setting of ischemia-reperfus

120 t or brain; conversely, epithelial serotonin synthesis inhibition increased anxiety and depression-li

121 DCs display an unusual resistance to protein synthesis inhibition induced in response to cytosolic ds

122 Triggering cell lysis by peptidoglycan synthesis inhibition is a traditional route for antimicr

123 These results suggest (1) that protein-synthesis inhibition is an important consideration in th

124 Transient protein synthesis inhibition is an important protective mechanis

125 Protein synthesis inhibition is required to sensitize the endoth

126 extinction and that postreactivation protein synthesis inhibition leads to an inability to retrieve t

127 NO synthase blockade and acute prostaglandin synthesis inhibition led to the equalization of GFR, ERP

128 ns were sought with these parameters and DNA synthesis inhibition measured ex vivo by [3H]thymidine i

129 with superimposition of acute prostaglandin synthesis inhibition (meclofenamate, 10 mg/kg IV), renal

130 Transient protein synthesis inhibition, mediated by phosphorylation of the

131 atosis in alcohol-fed mice, but only de novo synthesis inhibition, not sphingomyelin hydrolysis, impr

132 The NO synthesis inhibition observed for raw CPH was reduced af

133 viability was greatly preserved when protein synthesis inhibition occurred after peroxide induction.

134 s of both effects are rapid, with fatty acid synthesis inhibition occurring within 30 min and DNA syn

135 s inhibition occurring within 30 min and DNA synthesis inhibition occurring within 90 min of drug exp

136 arrest at the G0/G1 phase, inhibition of DNA synthesis, inhibition of cyclin D and cyclin E promoter

137 P < 0.05) that are involved in cell membrane synthesis, inhibition of protein synthesis, interference

138 amined the effects of pharmacologic ceramide synthesis inhibition on hepatic PLIN2 expression, steato

139 n accumulation, azithromycin-induced protein synthesis inhibition, oprM (encoding the outer-membrane

140 The effects of GA synthesis inhibition or exogenous GA application differe

141 cells subjected to stresses, such as protein synthesis inhibition or UV irradiation.

142 ensitive electrode, that was abolished by NO synthesis inhibition, or endothelium removal, and reduce

143 -3 activation was also attenuated by protein synthesis inhibition, p53 deficiency, or Bax deficiency,

144 sis inhibition to show that targeted protein synthesis inhibition pan-neuronally and in excitatory ne

145 ogether, our results suggest that nucleotide synthesis inhibition plays a causative role in the estab

146 In addition, heme synthesis inhibition promotes the acquisition of 2 cell-

147 ruption of original consolidation by protein synthesis inhibition (PSI) begun shortly after training.

148 Persistent protein synthesis inhibition (PSI) is a robust predictor of even

149 ed to examine the impact of systemic protein synthesis inhibition (PSI) on the reconsolidation of a c

150 I-labeled ligand binding competition and DNA synthesis inhibition revealed that IGFBP-3 was a more po

151 Ethylene synthesis inhibition revert the constitutive Fe uptake p

152 Protein synthesis inhibition selectively stabilized PTC containi

153 or cell-type-specific drug-inducible protein synthesis inhibition that enables rapid and reversible p

154 ons of mitochondrial and cytoplasmic protein synthesis inhibition to AG-induced ototoxicity.

155 Using protein synthesis inhibition to measure enzymatic activity, the

156 se cell-type-specific drug-inducible protein synthesis inhibition to show that targeted protein synth

157 K activity was always accompanied by protein synthesis inhibition to some extent.

158 e-activated cell sorting analyses showed DNA synthesis inhibition uniformly throughout the S phase af

159 ulatory effect could be reversed through GSL synthesis inhibition using clinically approved drugs.

160 , were studied in vitro by examining protein synthesis inhibition using Vero monkey kidney cells and

161 DNA synthesis inhibition was dependent on the UPR effector P

162 For all G4s, DNA synthesis inhibition was higher on the G-rich than C-ric

163 The DNA-binding domain essential for DNA synthesis inhibition was mapped to within 42 amino acid

164 The extent of DNA synthesis inhibition was related to the residual concent

165 Percentages of protein synthesis inhibition were determined by comparing [(35)S

166 op1-mediated DNA single-strand breaks or DNA synthesis inhibition were observed after 1 h exposure to

167 noid signaling, or by 2-arachidonoylglycerol synthesis inhibition, which impairs postsynaptic endocan

168 )O(2) from elevating Nrf2 protein level, RNA synthesis inhibition with actinomycin D failed to do so.

169 he next experiment examined the effect of NE synthesis inhibition with bis(4-methyl-1-homopiperazinyl

170 tudies reveal that vancomycin-like cell wall synthesis inhibition with improved efficacy attributed t

171 tensin II hypertensive model of nitric oxide synthesis inhibition with L-NAME.

172 holesterolemic patients before and during NO synthesis inhibition with N(G)-monomethyl-L-arginine (4

173 ience can be disrupted; by contrast, protein synthesis inhibition without prior reminding commonly do