ライフサイエンスコーパス: synthetic

1 e an outlook about the future development of synthetic 2D CCFs for electrochemical applications, whic

2 (10-mm slabs with 5-mm overlap, 1-mm slices, synthetic 2D mammogram) and an experimental protocol (6-

3 ntal protocol (6-mm slabs with 3-mm overlap, synthetic 2D mammogram) with a crossover design.

4 compare translocation of phage, plasmid, and synthetic A-philic, GC rich sequences by the T4 motor.

5 toughness design approach can be applied to synthetic adhesives.

6 o increase mvPC's immunogenicity, we added a synthetic adjuvant (RS09) to the mvPC design.

7 e also able to identify a novel agonist, the synthetic analogue 2-fluoro-ATP, and to confirm its agon

8 Active matter, both synthetic and biological, demonstrates complex spatiotem

9 mulate single-cell transcriptional data from synthetic and Boolean networks that avoids pitfalls of p

10 approach using a birth-death model with both synthetic and experimental data, and show that we can ro

11 Using both synthetic and experimental datasets for comparison, we p

12 This fully synthetic and modular therapeutic platform could be an i

13 Using multiple synthetic and real data sets, we demonstrate ACTIONet's

14 er of enzymes that can be harnessed for post-synthetic and site-specific labeling of nucleic acids ha

15 -of-action of the small, rationally designed synthetic antifungal peptide PAF26 using the model fungu

16 This synthetic approach also allows access to unnatural deriv

17 )/C(60) 0D-2D heterostructures via a one-pot synthetic approach for catalytic hydrogen generation.

18 Here we show how a complementary divergent synthetic approach that is holistically patterned off of

19 An efficient synthetic approach to the tricyclic 1,7a-dihydro-1,3a-et

20 The one-pot synthetic approach yielded micellar nanoparticles at hig

21 Two synthetic approaches to the key heterocyclic aglycon 7,

22 often complementary to small molecule based synthetic approaches, providing a powerful tool when dep

23 of similar hybrid strategy that combines two synthetic approaches.

24 e at ambient conditions and require peculiar synthetic approaches.

25 the properties of a theophylline-responsive synthetic aptazyme for control of nuclear-encoded transg

26 Synthetic assembly within living cells represents an inn

27 r-sensitive AID system that incorporates the synthetic auxin derivative 5-Ad-IAA and its high-affinit

28 r Superfamily can successfully insert into a synthetic bilayer without the need for translocon insert

29 Here we have developed monobodies, synthetic binding proteins, that bind the N-terminal fou

30 oded in this underexploited resource using a synthetic-bioinformatic natural product (syn-BNP) approa

31 A synthetic biological module, however, can be designed to

32 roving drug treatment and the performance of synthetic biological systems.

33 become a prime model for cellular, evo-devo, synthetic biological, and evolutionary investigations.

34 as being introduced into circuit designs for synthetic biology applications.

35 table and engineer cell functions for future synthetic biology applications.

36 Our findings illustrate the power of a synthetic biology approach in which bottom-up constructi

37 citing opportunities to profoundly transform synthetic biology by enabling new approaches to the mode

38 A recent wave of synthetic biology efforts has focused on the establishme

39 eneration of useful promoters and facilitate synthetic biology efforts in this model organism.

40 logy, genetic engineering, gene editing, and synthetic biology exponentially expand opportunities to

41 One primary objective of synthetic biology is to improve the sustainability of ch

42 Here, we apply synthetic biology methods to reverse-engineer gene expre

43 in cellular engineering(1,2) have positioned synthetic biology to address therapeutic(3,4) and indust

44 In the first wave of synthetic biology, genetic elements, combined into simpl

45 r switches useful in biodesign, sensing, and synthetic biology, the behavior we have demonstrated--fu

46 In the second wave of synthetic biology, the simple circuits, combined into co

47 implications for rational protein design and synthetic biology.

48 function as a canonical riboswitch model in synthetic biology.

49 s applications in many areas of chemical and synthetic biology.

50 Specifically, a synthetic biomaterial containing boronate molecules is d

51 ht percentage of siRNA while also carrying a synthetic biosensing peptide on the surface that is clea

52 We focus on synthetic brush polymers of oligonucleotides, oligosacch

53 We presented synthetic calls during co-housing and observed that neur

54 The rapid proliferation of new synthetic cannabinoid receptor agonists (SCRAs) has init

55 In this study, we evaluated whether (synthetic) cannabinoid activity can be detected in oral

56 00 synthetic cases (S2DB); (c) CDB plus 2000 synthetic cases (CS2DB); and (d) CDB plus 40 000 synthet

57 hetic cases (CS2DB); and (d) CDB plus 40 000 synthetic cases (CS40DB).

58 cal DW positive stroke cases (CDB); (b) 2000 synthetic cases (S2DB); (c) CDB plus 2000 synthetic case

59 de array of systems, ranging from enzymes to synthetic catalysts, exert adaptive motifs to maximize t

60 s of informing the design of next generation synthetic catalysts.

61 se and direct fashion remains a contemporary synthetic challenge.

62 rmation in the regulatory risk assessment of synthetic chemicals.

63 drug discovery has used natural product and synthetic chemistry approaches to generate libraries of

64 Synthetic chemistry enables a bottom-up approach to quan

65 , it is also possible to use the reaction in synthetic chemistry for general formation of amide bonds

66 ortunities in diverse applications including synthetic chemistry, gas valorization, and greenhouse ga

67 In seeking to extend the lexicon of synthetic chemists in this regard, we have developed an

68 and now significantly enrich the toolbox of synthetic chemists.

69 f substrate cells, and gene-engineering with synthetic co-stimulatory circuits.

70 ssociation and changes the conception of new synthetic collagen designs.

71 omposition and register-specific assembly of synthetic collagen heterotrimers.

72 Here, we studied synthetic communities constructed from the core members

73 This enabled us to classify the synthetic community into four modules of co-occurring st

74 th the NMR data and specific rotation of the synthetic compounds with that of the reported data.

75 the choice of molecular building blocks and synthetic conditions, allowing for facile tailoring and

76 obtained in the crystalline form under mild synthetic conditions.

77 We use the synthetic control method to analyze the effect of face m

78 We adopted a photoinduced post-synthetic copolymerization strategy to realize a membran

79 n of the glucocorticoid receptor (GR) by the synthetic corticosteroid dexamethasone (DEX) stimulates

80 Nanoparticle occlusion in natural and synthetic crystals is a topic of wide-ranging interest o

81 mine the diagnostic performance of MRI-based synthetic CT (sCT) in the depiction of erosions, scleros

82 onclusion With CT as the reference standard, synthetic CT of the sacroiliac joints has better diagnos

83 the presence of NH(3) , thus establishing a synthetic cycle for Ni-mediated AO.

84 Validated with both realistic synthetic data and internal quality control samples, ncG

85 By using the MiCRM to generate synthetic data with different environmental and taxonomi

86 Synthetic datasets mimic real datasets by preserving the

87 This article introduces the concept of synthetic datasets, which is an emerging method original

88 ne (3alpha5alpha-P), pregnanolone, and their synthetic derivatives are potent positive allosteric mod

89 mensional topological physics with time as a synthetic dimension.

90 ring resonator with two independent physical synthetic dimensions.

91 The assay was developed with synthetic DNA templates and validated with DNA from two

92 allosteric protein transcription factors and synthetic DNA transcription templates regulates the synt

93 We have previously engineered a synthetic DNA vaccine targeting the MERS coronavirus Spi

94 The expression of synthetic elements is influenced by both the number and

95 ivity that can generate alanine, the primary synthetic enzyme for alanine is encoded by alaT, althoug

96 bly and elevated expression of the GABAergic synthetic enzyme GAD67 also cooperate to decrease and po

97 High-dose synthetic estrogen therapy was the standard treatment of

98 show that contraception can be achieved with synthetic estrogen, with progestin, and by combining the

99 A range of substituted triphenylethylene synthetic estrogens and diethylstilbestrol were used.

100 BFD1 accumulates during stress and its synthetic expression is sufficient to drive differentiat

101 we have prepared and characterized the first synthetic [Fe(4)S(4)](3+)-alkyl cluster.

102 Here, we show that synthetic [Fe(4)S(4)]-alkyl clusters undergo Fe-C bond h

103 be possible to compete with high-performance synthetic fibers such as glass fibers and carbon fibers

104 comes at the expense of selectivity in many synthetic filters.

105 However, despite the promise of synthetic flexibility and electronic design, fabrication

106 Nitrogen-based fuels pose one possible synthetic fuel pathway.

107 muli-triggered fusion and the development of synthetic fusogens for biomedical applications.

108 ross-linking in isolated human HDL either by synthetic gamma-ketoalkenal phospholipids or by oxPLs ge

109 new approaches to the model-driven design of synthetic gene networks, the fast and portable sensing o

110 Synthetic genes encoding Nanoluciferase polypeptides wer

111 c solutes as large as 40 kDa, in contrast to synthetic giant unilamellar vesicles.

112 that treatment with dexamethasone, a classic synthetic glucocorticoid, enhanced survival of criticall

113 sensitivity through covalent attachment of a synthetic glutamate-based photoswitch via a self-labelli

114 icited antibodies that recognized all of the synthetic glycans at 1:200-fold dilution.

115 irst time a MUC1-derived positional scanning synthetic glycopeptide combinatorial library (PS-SGCL) t

116 r the assembly, expression and processing of synthetic guide RNA arrays in vivo.

117 Finally, injection of synthetic hepcidin at the site of infection can limit or

118 self-assembly and subsequent collapse of the synthetic homopolymer poly(propylene sulfone).

119 Synthetic human alpha-defensin 5 (HD5) was orally given

120 antigens in phage display selections using a synthetic human single-chain fragment variable library.

121 nerate llama nanobodies (VHH) from naive and synthetic humanized VHH phage libraries that specificall

122 setting up the possibility of making natural-synthetic hybrid structures and conjugates.

123 ractions: unreacted and shale-reacted with a synthetic hydraulic fracture fluid.

124 Biogenic and synthetic hydroxyapatites are confounding materials whos

125 the mechanisms of these processes may enable synthetic improvements and development of new reactions.

126 ization of laccase for the decolorization of synthetic industrial dyes as a trial case.

127 onding sprayed treatments (with botanical or synthetic insecticide positive control) while treatments

128 The output was 30 synthetic intermediate projections (SIPs) per CUSIP.

129 oute to gamma-cyanoesters that can be useful synthetic intermediates for the synthesis of diverse bio

130 urements were conducted to identify relevant synthetic intermediates.

131 Here we construct synthetic Lactococcus lactis consortia and mathematical

132 s encoded as protein networks could identify synthetic lethal candidates that are more reproducible t

133 vivo These findings might pave a way for new synthetic lethal combination therapies.Significance: The

134 ystem is a practical approach in identifying synthetic lethal drug combinations for cancer treatment.

135 g, have made possible systematic screens for synthetic lethal drug targets in human cancers.

136 entifies numerous interactions that suppress synthetic lethal effects.

137 Furthermore, we showed that the synthetic lethal interaction between Haspin depletion an

138 A synthetic lethal interaction between PPP2R2A deficiency

139 ing of Synthetic Lethals (MiSL), to identify synthetic lethal interactions with the loss of VHL throu

140 l and cisplatin response beyond those of the synthetic lethal p53 mutant/MK2 combination alone.

141 al rather than technical limitations as most synthetic lethal phenotypes are strongly modulated by ch

142 the case of KRAS, we identify that published synthetic lethal screen hits significantly overlap at th

143 cancers, making fully small-molecule-induced synthetic lethality an innovative approach toward unmet

144 Synthetic lethality between poly(ADP-ribose) polymerase

145 Synthetic lethality is an innovative framework for disco

146 Although synthetic lethality is not a new idea, recent advances,

147 J ligands are amenable to chemically induced synthetic lethality strategies upon association with inh

148 vides a therapeutic opportunity and a unique synthetic lethality to exploit the distinctive metabolic

149 innovative computational platform, Mining of Synthetic Lethals (MiSL), to identify synthetic lethal i

150 ipid acyl chain (i.e., lipid packing) in the synthetic lipid vesicles.

151 es of single-component liposomes composed of synthetic lipids of varying chain lengths, we demonstrat

152 o, establishing a potential route to simple, synthetic, low-cost antivenoms.

153 tumor microenvironment and suggests use of a synthetic LXR agonist as a novel therapeutic strategy to

154 and thus drives every interaction that this synthetic material has with its environment, from ecotox

155 The structure of the synthetic material was further corroborated by obtaining

156 gnificant step forward in the development of synthetic materials that rival their highly functional,

157 property of spider silks rarely observed in synthetic materials, highlights possibilities for furthe

158 -black coloration comparable to the blackest synthetic materials.

159 with insect-wing mimetic nanopillars made of synthetic materials.

160 this work, we used two- and three-component synthetic membranes (liposomes) and the plasma membrane

161 This has prompted the development of synthetic membranes to study lipid-lipid interactions in

162 hospholipids in both the plasma membrane and synthetic membranes, and is sufficient to induce extensi

163 ntrolled, and reconstituting viral fusion to synthetic membranes, which introduces nonphysiological m

164 -cell receptors are presented via the fluid, synthetic membranes, while mitogenic cues are released s

165 While many synthetic methods afford PPVs with all-trans stereochemi

166 tion of 2D TMD research, discussing both the synthetic methods that have enabled the preparation of t

167 , two-phase, and post-nanoparticle-synthesis synthetic methods to TMC/AuNP hybrids are discussed and

168 , turning a non-methylotrophic organism to a synthetic methylotroph that grows to a high cell density

169 ivariable logistic regression analysis, with synthetic minority oversampling techniques, was used.

170 were decreased in control mice injected with synthetic miR-144.

171 to achieve SAR tractability in a challenging synthetic modality.

172 periments, and gram-scale synthesis make the synthetic model viable and significant.

173 ocesses of life, have stimulated interest as synthetic models of natural systems and integral compone

174 the therapeutic effect of their natural and synthetic modulators, and it will discuss insights for t

175 , which in turn enhances the function of the synthetic module.

176 confined space is critical for the design of synthetic molecular machines.

177 Artificial water channels are synthetic molecules that aim to mimic the structural and

178 lutional neural networks (DCNNs) to generate synthetic MRI ventilation scans from free-breathing MRI

179 t, and rice), together accounting for 72% of synthetic N fertilizer-induced NH(3) emissions from crop

180 he electrical power densities generated from synthetic NaCl solutions and the crystal structures and

181 reening a yeast surface-displayed library of synthetic nanobody sequences, we developed nanobodies th

182 face-passivated gold nanoparticles behave as synthetic nanonucleases, able to cleave pBR322 plasmid D

183 es is presented, including carbon nanotubes, synthetic nanopores, model peptide nanopores, track-etch

184 observed offspring to carefully constructed synthetic offspring from the same parents to determine s

185 (limit of detection of 0.9 pM for the short synthetic oligomer) using a much simpler and faster prot

186 he construction of FISH probes entirely from synthetic oligonucleotides (oligos), allowing the optimi

187 , a natural mineral with a strong analogy to synthetic open-cell foams.

188 Methadone is a synthetic opioid agonist with notoriously unique propert

189 Furthermore, we consider the integration of synthetic optically active nanocomponents into organized

190 We detail our full synthetic optimization for the isolation of these cluste

191 e hue range, stability, and affordability of synthetic options.

192 try with MeV ions (MeV-SIMS) for analysis of synthetic organic pigments (SOPs) that can be usually fo

193 ration, site-specific labeling of RNAs, semi-synthetic organism creation, and unnatural-amino-acid-co

194 Synthetic overlapping 15-mer peptides of peanut allergen

195 ped a temperature-based screening method for synthetic paralysis that can be used to rapidly identify

196 hase and other components of the ganglioside synthetic pathway are crucial host factors that are requ

197 elds varying from 32 to 64% according to two synthetic pathways: (1) using a titanium-reductive amina

198 of the enzyme-instructed self-assembly of a synthetic peptide for trafficking endogenous proteins, t

199 es and root and nodule phenotyping data from synthetic peptide screens in planta.

200 enes; and (4) information about a library of synthetic peptides and root and nodule phenotyping data

201 In this study, we designed synthetic peptides derived from indolicidin, a naturally

202 and oncogenicity of HAdVs, the structures of synthetic peptides identical or very similar to the aden

203 ty and structural variability of natural and synthetic peptides, the two directions have so far not b

204 e, and for parallel measurements using model synthetic petroleum mixtures (consisting of representati

205 A synthetic phage display library based on the variable do

206 g Fn-EDA in human aortic SMCs suppressed the synthetic phenotype and downregulated Akt1/mTOR signalin

207 Stimulation of the QS system using synthetic pheromones prior to inoculation did not signif

208 Synthetic pigment and pigmented human cartilage tissue b

209 work exploration times for a variety of both synthetic planar networks and organelle morphologies ext

210 results indicate that expert-level automated synthetic planning is feasible, pending continued improv

211 ntified permissive architectures for minimal synthetic plant promoters enabling the computational des

212 ermined, resulting in a reliable and tunable synthetic platform applicable for a broad range of subst

213 We describe a process for engineering a synthetic polymer nanoparticle (NP) that functions as an

214 d if it benefits from biodegradation of this synthetic polymer.

215 phase diagrams of macromolecules, including synthetic polymers and proteins.

216 The control of the tacticity of synthetic polymers enables the realization of emergent p

217 reactive transport processes in natural and synthetic porous materials, beyond the current dispersio

218 matic compounds could open up a multitude of synthetic possibilities.

219 ent reactions are presented to emphasize the synthetic potential of this novel strategy.

220 Biochemical studies of the particular synthetic PrAMP oncocin112 (Onc112) suggest that on reac

221 ew, we focus specifically on summarizing the synthetic principles and strategies developed to form ra

222 An easily handled one-pot synthetic procedure was previously developed for the syn

223 trol of regioselectivity requires multi-step synthetic procedures to prepare the desired tether or ma

224 bling the computational design of a suite of synthetic promoters of different strengths.

225 e interactions by measuring Cbf1p binding at synthetic promoters with multiple sites.

226 teraction was blocked by previously-reported synthetic proteins, termed monobodies, that bind the GPR

227 An exciting feature of this synthetic protocol is that the reaction mechanism and fo

228 The synthetic protocol to form chiral pyrrolidines was furth

229 Here we report a synthetic protocol toward a merocyanine (MC) pentamer 1

230 th Fe(3+)-ions via very simple eco- friendly synthetic protocol.

231 property capacity but with typically tedious synthetic protocols.

232 The synthetic results unambiguously confirmed the absolute c

233 pression in plastids, but the application of synthetic riboswitches for the regulation of nuclear-enc

234 In plants, synthetic riboswitches were used to regulate gene expres

235 Overall, the project provides a valuable synthetic roadmap for medicinal chemists to access a ran

236 e report how a metal organic framework (MOF) synthetic route can be optimized using an in situ monito

237 We describe an efficient synthetic route to differentially protected diester, 1-(

238 In this work, we propose a simple synthetic route to obtain different vlasouliolides in go

239 ists of a one-pot straightforward three-step synthetic route, including (i) CuBr(2)-mediated alpha-br

240 ied successfully for the detection of VAN in synthetic samples and various food samples.

241 We investigated this process on a synthetic scale, leading to the discovery of an Amadori-

242 ectrochemical allylic alkylation expands the synthetic scope of cross-coupling reactions and can be f

243 ve seen great advances in the development of synthetic self-assembling molecular systems.

244 This short synthetic sequence enabled investigation of both hemiast

245 nt an automated benchmarking workflow, using synthetic shotgun sequencing reads for which we know the

246 nalysis of GD3-binding toward Siglec-7 using synthetic sialoglycoconjugates and a comprehensive set o

247 Applying synthetic signaling approaches to plants offers the prom

248 ASOs are small synthetic single-stranded chains of nucleic acids that t

249 Both AM-derived EVs and synthetic SOCS3 liposomes inhibited the activation of ST

250 n uptake strategies, were grown in irrigated synthetic soil under semiarid conditions with gravimetri

251 We, herein, present a collection of synthetic, spectroscopic and theoretical investigations

252 s the 2-substituted-2H-indazoles in a single synthetic step with yields up to 79%.

253 f 173 unique functional molecules in minimal synthetic steps.

254 nen-20-carboxaldehyde, a biologically active synthetic steroid, by using a 1,3-dipolar cycloaddition

255 Application of the developed synthetic strategies and methods provided a series of de

256 are currently only a small number of guiding synthetic strategies available to generate novel NP-insp

257 Various synthetic strategies have been developed over the years

258 peptide (IDR)-1018 based on three different synthetic strategies including head-to-tail cyclization

259 merization reactions are the cornerstones of synthetic strategies, which directly provides the direct

260 Suitable polymerization reaction and synthetic strategy are both critical for the obtainment

261 The synthetic strategy demonstrates the unique ability to in

262 This synthetic strategy provides concise and potentially exte

263 We have developed an efficient synthetic strategy to access 2,5-diaryl nonsymmetric fur

264 A synthetic strategy to fused bicyclic piperidines-buildin

265 Herein, we describe the evolution of our synthetic strategy toward 4 and report the series of dis

266 r, these results offer a potentially general synthetic strategy toward new materials with exotic meta

267 The synthetic strategy was based on the Wittig-Horner coupli

268 ine ring system is elaborated using a simple synthetic strategy.

269 Brain volumes with synthetic stroke lesions on DW images were produced by w

270 On the contrary, synthetic structural materials have unchanging mechanica

271 noids were accessed chemoenzymatically using synthetic substrates.

272 Advances in anion transport by synthetic supramolecular systems are discussed in this a

273 r from a dense liquid precursor, observed in synthetic systems but never in biogenic ones.

274 guidelines for replicating this strategy in synthetic systems.

275 o facilitates novel experimental methods for synthetic, systems, and evolutionary biology and broaden

276 Using synthetic tap water and new lead pipes, we developed a s

277 NA reduces KSHV infection facilitated by the synthetic TAR RNA in oral epithelial cells.

278 ated cages represent chemistry's challenging synthetic targets because a three-dimensional assembly i

279 ma-quaternary amino acids and other valuable synthetic targets.

280 ility of retrosynthetically guided access to synthetic Taxol, albeit in minute quantities and with en

281 ponents of the expanding range of asymmetric synthetic techniques.

282 onstitution of enzymatic tetracyclization of synthetic teicoplanin-derived heptapeptides and furtherm

283 the development of prebiotic, probiotic, or synthetic therapeutics that decrease the risk of autoimm

284 on and biomedical application of natural and synthetic thermoresponsive hydrogels are critically pres

285 ced an ALK1-dependent phenotypic switch from synthetic to contractile in pulmonary VSMCs.

286 A facile efficient synthetic tool, Buchwald-Hartwig cross-coupling reaction

287 able, obviating the requirement for an extra synthetic transformation into more stable boron species,

288 a-unsaturated ketones constitutes a powerful synthetic transformation.

289 complete understanding of these photoinduced synthetic transformations.

290 ordination of Al species can facilitate post-synthetic treatment to produce mesoporous ZSM-5 nanoboxe

291 After saturating the synthetic tree by boiling it underwater, water can flow

292 Synthetic trees can mimic this transpiration cycle, but

293 (2-trifluoromethyl-2'-methoxychalone), a new synthetic trifluorinated chalcone and Nrf2 agonist, for

294 e was applied for serotonin determination in synthetic urine using differential-pulse voltammetry wit

295 Emphasis is placed on the synthetic utility of cyclopropanols and related derivati

296 To show the synthetic utility of the catalytic C-C activation of les

297 We also demonstrate the synthetic value of these DHIQs by further functionalizat

298 Additionally, the synthetic versatility of the CF(2)Br intermediates was s

299 ultiple ensemble methods using both real and synthetic whole-genome sequencing, whole-exome sequencin

300 These new synthetic yeast hybrids and the iHyPr method have potent