ライフサイエンスコーパス: synthetic biology

1 e blurred by bridging top-down and bottom-up synthetic biology.

2 tronic mRNAs, expanding the toolkit of plant synthetic biology.

3 stems are vital tools for the advancement of synthetic biology.

4 ese colorful pigments attractive targets for synthetic biology.

5 or artificial cell construction in bottom-up synthetic biology.

6 NA functions and developing genetic tools in synthetic biology.

7 gle-cell transcriptomics are advancing plant synthetic biology.

8 re for applications in mRNA therapeutics and synthetic biology.

9 mising tool for applications in chemical and synthetic biology.

10 try and mechanistic modeling to medicine and synthetic biology.

11 applications in chemistry, biotechnology and synthetic biology.

12 s applications in many areas of chemical and synthetic biology.

13 ases the tool kit for RNA nanotechnology and synthetic biology.

14 been and remains one of the central aims of synthetic biology.

15 ts great potential in accelerating cell-free synthetic biology.

16 as a versatile and truly modular platform in synthetic biology.

17 mechanistic routes for drug development and synthetic biology.

18 reactions for applications in chemistry and synthetic biology.

19 r translation fidelity, and potential use in synthetic biology.

20 unctional designs in protein engineering and synthetic biology.

21 ovel molecular architectures and devices for synthetic biology.

22 n Nature and represents an important goal in synthetic biology.

23 d allow the automatic design of circuits for synthetic biology.

24 responsive module for RNA nanotechnology and synthetic biology.

25 how we can utilize these variations in plant synthetic biology.

26 uct pathways in heterologous systems through synthetic biology.

27 opportunities for robust nanoconstruction in synthetic biology.

28 fied challenges into opportunities for plant synthetic biology.

29 rotocells is an unexplored area of bottom-up synthetic biology.

30 ese photosensing systems in optogenetics and synthetic biology.

31 perties are emerging challenges in bottom-up synthetic biology.

32 powerful capabilities for biotechnology and synthetic biology.

33 f next-generation immune cell therapies with synthetic biology.

34 ene and genome transfer in biotechnology and synthetic biology.

35 h that is the nexus of chemical genomics and synthetic biology.

36 network is a major challenge in cellular and synthetic biology.

37 o the field of artificial metalloenzymes and synthetic biology.

38 ing and manipulating microbial metabolism by synthetic biology.

39 also being exploited in multiple contexts in synthetic biology.

40 analogues of membrane proteins have advanced synthetic biology.

41 of novel and more functional protocells for synthetic biology.

42 increasingly important tool in molecular and synthetic biology.

43 DNA assembly forms the cornerstone of modern synthetic biology.

44 ns in biomolecular design, biotechnology and synthetic biology.

45 eactions that have potential applications in synthetic biology.

46 se applications in molecular programming and synthetic biology.

47 diversity by combinatorial biosynthesis and synthetic biology.

48 reat promise to advance the growing field of synthetic biology.

49 e findings have implications in the field of synthetic biology.

50 nanostructure-based molecular circuitry for synthetic biology.

51 thus protect against the potential misuse of synthetic biology.

52 e biophysics, as well as in cell biology and synthetic biology.

53 based metabolic modules for new functions in synthetic biology.

54 ave significance in space bioengineering and synthetic biology.

55 cal for sophisticated cell engineering using synthetic biology.

56 posttranscriptional level is a challenge for synthetic biology.

57 nd will greatly advance plant functional and synthetic biology.

58 e model organisms for microalgal systems and synthetic biology.

59 implications for rational protein design and synthetic biology.

60 complex life science workflows ushered in by synthetic biology.

61 ty predictions and insight generation in RNA synthetic biology.

62 or the development of therapeutic agents and synthetic biology.

63 for applications in medical diagnostics and synthetic biology.

64 considerable challenge in biotechnology and synthetic biology.

65 function as a canonical riboswitch model in synthetic biology.

66 milestone in achieving the full potential of synthetic biology(10,11,12).

67 ction is now a standard design principle for synthetic biology(2,3).

68 Synthetic biology, a field where scientists seek to desi

69 our device holds potential for making modern synthetic biology accessible in high school, community,

70 These Synthetic Biology adjuvants also elicited similar IgG1,

71 Synthetic biology aims to design and construct bacterial

72 Synthetic biology aims to develop programmable tools to

73 Synthetic biology allows us to bioengineer cells to synt

74 tive developmental genetics, bioengineering, synthetic biology and artificial life aimed to reveal ho

75 h living cells is an important challenge for synthetic biology and bio-engineering.

76 erable potential for applications throughout synthetic biology and bio-manufacturing as they are able

77 t OMVs could potentially be useful tools for synthetic biology and biotechnological applications.

78 way for use of the 3-HP-inducible system in synthetic biology and biotechnology applications.

79 rstanding of this system has implications in synthetic biology and biotechnology, for example, in app

80 protein design, and opens up new avenues for synthetic biology and cell engineering.

81 halo-metabolites in living cultures.Coupling synthetic biology and chemical reactions in cells is a c

82 This revealed novel design principles in synthetic biology and demonstrated the power of SIFT to

83 This work provides a valuable tool to synthetic biology and demonstrates remarkable versatilit

84 applications of modern biotechniques, namely synthetic biology and gene drives, are discussed, and a

85 eases are at the forefront of biotechnology, synthetic biology and gene editing.

86 ine integrases are emerging as core tools in synthetic biology and have applications in biotechnology

87 cell mRNA-sequence analysis, bioinformatics, synthetic biology and high-throughput functional analysi

88 re, we construct a virus laser which bridges synthetic biology and laser physics, and demonstrate vir

89 Synthetic biology and metabolic engineering have expande

90 les match a diverse range of applications in synthetic biology and nanomaterials.

91 chitecture, addressing a significant need in synthetic biology and offering a versatile new tool for

92 However, advances in synthetic biology and organic synthesis have inspired a

93 This increased understanding is valuable for synthetic biology and potentially also for medicine.

94 split inteins for their use in the fields of synthetic biology and protein engineering.

95 We combined synthetic biology and supramolecular assembly to prepare

96 aryotic physiology with marked potential for synthetic biology and surface-display applications.

97 ding toolkits for future strain engineering, synthetic biology, and broader efforts.

98 ophisticated protein-based control logic for synthetic biology, and illustrates that nature has not f

99 r use as model cell membranes in biophysics, synthetic biology, and origins of life studies.

100 urrent dCas tools in genetic engineering and synthetic biology, and provide perspectives on future di

101 this technology opens new opportunities for synthetic biology applications due to the versatility of

102 e and control microbial colony structure for synthetic biology applications in complex environments.

103 ontrol assembly and function in cellular and synthetic biology applications of LLPS.

104 of many genes for metabolic engineering and synthetic biology applications.

105 ion of drug resistance and developing future synthetic biology applications.

106 to further develop unnatural base-pairs for synthetic biology applications.

107 as being introduced into circuit designs for synthetic biology applications.

108 hampering the design of engineered genes for synthetic biology applications.

109 entially very advantageous for biotechnology/synthetic biology applications.

110 th genetic analysis of gene function and for synthetic biology applications.

111 table and engineer cell functions for future synthetic biology applications.

112 eal host for a variety of sustainability and synthetic biology applications.

113 ps within the ribosome and make possible new synthetic biology applications.

114 ing increasingly important in the context of synthetic biology applied to de novo pathway discovery a

115 es will eventually succeed, I suggest that a synthetic biology approach - moving free-living nematode

116 optimize phytoene biosynthesis, we applied a synthetic biology approach and constructed a chimeric GG

117 To investigate isoDCA in vivo, we took a synthetic biology approach and designed minimal microbia

118 The 4 x 4 array derived by this bottom-up synthetic biology approach can detect grey-scale images

119 Using stochastic simulations and a synthetic biology approach in E. coli, we find that the

120 Our findings illustrate the power of a synthetic biology approach in which bottom-up constructi

121 Here, we use a synthetic biology approach to demonstrate that this cons

122 hanisms of filament assembly, we have used a synthetic biology approach to reconstitute, in a nonnati

123 Here we use a synthetic biology approach to set a series of hPTM-contr

124 synthases and accessory proteins, we chose a synthetic biology approach to synthesize plant HM in yea

125 nant protein production by P. pastoris and a synthetic biology approach to this industrial host.

126 top-bottom leaf patterning and from a novel synthetic biology approach.

127 To overcome this barrier, we developed a synthetic-biology approach based on a technique known as

128 Here, we use a synthetic-biology approach to assemble patterned materia

129 The emergence of synthetic biology approaches for cellular engineering pr

130 However, traditional synthetic biology approaches involve ad-hoc engineering

131 The production of BIAs through synthetic biology approaches provides a higher-yielding

132 Here, we report synthetic biology approaches to co-produce high-value se

133 targets for antibacterial drugs and informed synthetic biology approaches to design and manufacture i

134 will remain a useful resource for extending Synthetic Biology approaches towards non-standard bacter

135 In this study, using molecular and synthetic biology approaches, biochemistry, radiolabelin

136 orated with foreign antigens using different synthetic biology approaches.

137 Rapid advances in synthetic biology are enabling us to exploit the informa

138 Systems biology and synthetic biology are increasingly used to examine and m

139 Increasingly, researchers in synthetic biology are relying on and developing massive

140 aboratory and transformative applications of synthetic biology are still in their infancy.

141 Emerging technologies, such as genomics and synthetic biology, are enabling new ways for discovering

142 l advances have accelerated the emergence of synthetic biology as a new discipline (Cameron et al., 2

143 oven widely applicable for biotechnology and synthetic biology as ligand-specific biosensors enabling

144 tional tissues for regenerative medicine and synthetic biology as well as new machine learning archit

145 ould both provide tools for biocatalysis and synthetic biology, as well as guide efforts to uncover n

146 sing the production of renewable alkanes via synthetic biology-based approaches.

147 istance with Isomap and Laplacian Eigenmaps, synthetic biology biobircks are successfully visualized

148 eaction cascades are of great importance for synthetic biology, biochemistry and bioengineering.

149 (ssDNA) of lengths >200 nucleotides (nt) in synthetic biology, biological imaging and bionanotechnol

150 n these being a problematic time, we've seen synthetic biology blossom and deliver many new technolog

151 citing opportunities to profoundly transform synthetic biology by enabling new approaches to the mode

152 l of membrane proteins in nanotechnology and synthetic biology by manipulating global bilayer propert

153 ogy has the potential to expand the field of synthetic biology by providing an interface for material

154 Synthetic biology can be used to overcome these challeng

155 ches with advances in sensor development and synthetic biology can provide enabling tools for preclin

156 SimCells represent a simplified synthetic biology chassis that can be programmed to manu

157 icroorganisms offer novel characteristics as synthetic biology chassis, and the toolbox of components

158 ired to further develop this organism into a synthetic biology chassis.

159 ated for broad applications in the yeast and synthetic biology communities that contains only the fou

160 Given this, many in the synthetic biology community have started to ask: is it p

161 Predicting the behavior of these synthetic biology components remains a challenge, a situ

162 Here, we apply this holistic synthetic biology concept to the engineering of cell-fre

163 elp develop mutations or over-expression and synthetic biology constructs to identify genes in P. aer

164 By extracting biobricks from synthetic biology database Registry of Standard Biologic

165 teria, which lag behind other prokaryotes in synthetic biology despite their huge potential regarding

166 d to facilitate base editing applications in synthetic biology, disease modeling, and regenerative me

167 A recent wave of synthetic biology efforts has focused on the establishme

168 eneration of useful promoters and facilitate synthetic biology efforts in this model organism.

169 r aryl O-demethylation and as a component of synthetic biology efforts to valorize previously underus

170 As the fields of biotechnology and synthetic biology expand, cheap and sensitive tools are

171 t here the results of chemical, genetic, and synthetic biology experiments to decipher the biosynthes

172 logy, genetic engineering, gene editing, and synthetic biology exponentially expand opportunities to

173 mogenetics toolbox to benefit the burgeoning synthetic biology field.

174 es are extensively used in biotechnology and synthetic biology for assembly and rearrangement of DNA

175 repurposing natural microcompartments using synthetic biology for biotechnological applications.

176 throughput framework may serve to accelerate synthetic biology for clinical applications and for unde

177 demonstrates the transformative potential of synthetic biology for the treatment of human disease whe

178 This work provides a synthetic biology framework to approach cell fate determ

179 In the first wave of synthetic biology, genetic elements, combined into simpl

180 Synthetic biology, genome engineering and directed evolu

181 pid strain manipulation with applications in synthetic biology, genome minimization and the removal o

182 of CRISPR-Cas9 in medicine, agriculture, and synthetic biology has accelerated the drive to discover

183 The use of this circuit as a tool for synthetic biology has been hampered by a lack of mechani

184 Modern synthetic biology has been reinvented as an engineering

185 A longstanding goal of synthetic biology has been the programmable control of c

186 Synthetic biology has been used both to assess and modul

187 Furthermore, synthetic biology has expanded the cell engineering tool

188 Synthetic biology has focused on engineering genetic mod

189 Synthetic biology has focused on engineering microbes to

190 Synthetic biology has promised and delivered on an impre

191 While synthetic biology has revolutionized our approaches to m

192 Synthetic biology has the potential to bring forth advan

193 The field of synthetic biology has used the engineered assembly of sy

194 Advances in synthetic biology have already demonstrated the capacity

195 Advances in synthetic biology have led to an arsenal of proof-of-pri

196 rated by -omic scale data, phylogenetics and synthetic biology, have shed light on the evolution of t

197 d probabilistic modeling techniques to guide synthetic biology in a systematic fashion, without the n

198 ady progress in establishing foundations for synthetic biology in plant systems.

199 for externally controlled gene expression in synthetic biology in plants or functional crop design.

200 Synthetic biology is a powerful tool to create therapeut

201 Plant synthetic biology is a rapidly evolving field with new t

202 Synthetic biology is advancing into a new phase where re

203 Synthetic biology is among the most hyped research topic

204 Synthetic biology is an established but ever-growing int

205 Synthetic biology is characterized by efforts targeted a

206 Synthetic biology is driving a new era of medicine throu

207 ussed, and their potential utility for plant synthetic biology is explored.

208 Synthetic biology is now poised to transform the potenti

209 One fundamental challenge in synthetic biology is the lack of quantitative tools that

210 A major goal of synthetic biology is to define the minimal cellular mach

211 An important goal in synthetic biology is to engineer biochemical pathways to

212 A defining goal of synthetic biology is to engineer cells to coordinate tas

213 One goal of synthetic biology is to improve the efficiency and predi

214 One primary objective of synthetic biology is to improve the sustainability of ch

215 Synthetic biology is transforming therapeutic paradigms

216 emergence of genome editing technologies and synthetic biology, it is now possible to engineer geneti

217 We cite specific examples from the synthetic biology literature that illustrate these princ

218 ization, and, with examples, demonstrate how synthetic biology may maximize CO2 uptake within and abo

219 moters are a central regulatory component in synthetic biology, metabolic engineering, and protein pr

220 Here, we apply synthetic biology methods to reverse-engineer gene expre

221 In addition, the synthetic biology methods we develop to port this pathwa

222 In synthetic biology, methods for stabilizing genetically e

223 malisms, that will be useful in engineering, synthetic biology, microbiology and genetics.

224 And with advances in the field of synthetic biology, microfluidics and lithography, many e

225 ent very promising opportunities for further synthetic biology modification and for a variety of biot

226 pate these regulators will find broad use as synthetic biology moves beyond parts engineering to the

227 The combination of cell-free synthetic biology, nanodisc-technology and non-covalent

228 Using the tools of synthetic biology, nonpathogenic bacteria can be designe

229 accelerate community efforts in systems and synthetic biology of these industrially important microa

230 Recent advances in synthetic biology offer new routes to this chemical dive

231 Gene editing, gene drives, and synthetic biology offer novel opportunities to control v

232 Synthetic biology offers the potential to expand communi

233 technology, emboldened by recent advances in synthetic biology, offers to generate sustainable biolog

234 smids is available in machine-readable SBOL (Synthetic Biology Open Language) format.

235 the design of next-generation DNA pores for synthetic biology or biomedicine.

236 cluding systems designed for applications in synthetic biology or metabolic engineering.

237 ly present in nature and is also employed in synthetic biology, partly to reduce gene expression nois

238 the localized feedback model, we developed a synthetic biology platform based on mammalian cells expr

239 I diTPS functions in plants, and may promote synthetic biology platforms for a broader spectrum of di

240 esting biosensor constructs, developed using synthetic biology principles, in different bacterial gen

241 versity and expand the toolbox available for synthetic biology programmes for sustainable production

242 The new field of synthetic biology promises to change health care, comput

243 To facilitate the management of complexity, synthetic biology relies on an abstraction hierarchy com

244 Recent advances in synthetic biology research have been underpinned by an e

245 erstone of biomedical, biotechnological, and synthetic biology research.

246 elp us to understand the challenges faced by synthetic biology researchers.

247 oswitches have gained attention as tools for synthetic biology, since they enable researchers to repr

248 Here, we review advances in synthetic biology, single cell genomics, and multiscale

249 f Saccharomyces cerevisiae as a platform for synthetic biology, strain engineering remains slow and l

250 Here, we review recent synthetic biology strategies for manipulating quorum sen

251 hetic carbon assimilation can be overcome by synthetic biology strategies.

252 cillators, and (2) perform complex tasks for synthetic biology, such as counting noisy biological eve

253 plant material) or biosynthetically derived (synthetic biology) supplies.

254 One promising approach is to use synthetic biology techniques to engineer simple genetic

255 The integration of synthetic biology technology with bacteria enables their

256 Synthetic signaling is a branch of synthetic biology that aims to understand native genetic

257 cations in basic research, biotechnology and synthetic biology that involve the multistep engineering

258 r switches useful in biodesign, sensing, and synthetic biology, the behavior we have demonstrated--fu

259 With advancements in synthetic biology, the cost and the time needed for desi

260 In the second wave of synthetic biology, the simple circuits, combined into co

261 e combine a new computational algorithm with synthetic biology to access biologically active small mo

262 in cellular engineering(1,2) have positioned synthetic biology to address therapeutic(3,4) and indust

263 ding a proof of concept for the potential of synthetic biology to assist agricultural practices in en

264 Of particular interest is the application of synthetic biology to chloroplast biotechnology to genera

265 m sensing processes can be used as a tool in synthetic biology to construct synthetic cocultures with

266 cted technologies of genetic engineering and synthetic biology to create entertaining stories.

267 Microbe, and Isabella et al. (2018), employ synthetic biology to develop a live bacterial therapeuti

268 networks, but also to perform sophisticated synthetic biology to develop innovative engineered stem

269 petitiveness and effectiveness, we have used synthetic biology to develop reporter plasmids that allo

270 acement principles have also been applied in synthetic biology to enable artificial gene regulation a

271 enzyme families, which can be mimicked using synthetic biology to engineer diverse bioactive molecule

272 Applying synthetic biology to engineer gut-resident microbes prov

273 y, we give a long-term vision for the use of synthetic biology to engineer immune cells as a general

274 ish a library of devices that can be used in synthetic biology to facilitate modular circuit design.

275 Here we use bioinformatics and synthetic biology to mine the human microbiota for N-acy

276 Applications of synthetic biology to photosynthesis currently range from

277 system is therefore a powerful and versatile synthetic biology tool for diverse research and industri

278 MAGIC represents a powerful synthetic biology tool to investigate fundamental biolog

279 approach will be a valuable addition to the synthetic biology toolkit, facilitating the understandin

280 signed to combat cancer, focusing on how new synthetic biology tools are providing potential ways to

281 Using synthetic biology tools combined with long-read DNA sequ

282 ts to accelerate the development of reliable synthetic biology tools for the cyanobacterial community

283 Synthetic biology tools provide novel functionality to c

284 In this study, we review synthetic biology tools that are being applied to effect

285 echnology can be achieved with the growth of synthetic biology tools that manipulate microbial electr

286 This study offers new synthetic biology tools to program spatial structures.

287 the emerging next generation of systems and synthetic biology tools, targeting the genotype-phenotyp

288 Synthetic biology uses living cells as the substrate for

289 acilitate their successful implementation in synthetic biology ventures.

290 Synthetic biology was founded as a biophysical disciplin

291 Initially, progress in the nascent field of synthetic biology was slow due to the ad hoc nature of m

292 With the rapid advancement of synthetic biology, we can now engineer and equip immune

293 To fully realize the promise of synthetic biology, we must be aware of life's unique pro

294 n important problem both in evolutionary and synthetic biology, where repairing natural or synthetic

295 Synthetic biology will transform how we grow food, what

296 essors) have been engineered and employed in synthetic biology with great success.

297 Marrying synthetic biology with synthetic chemistry provides a po

298 rogram cellular behaviour is a major goal of synthetic biology, with applications in health, agricult

299 anella oneidensis MR-1 is quickly becoming a synthetic biology workhorse for bioelectrochemical techn

300 his study, we have demonstrated the use of a Synthetic Biology (yeast) production platform to generat