ライフサイエンスコーパス: synthetic cell

1 nthetic genome that can be used to produce a synthetic cell.

2 rk for the development of a self-replicating synthetic cell.

3 ate partial molecular self-regeneration in a synthetic cell.

4 artificial cortices for the stabilization of synthetic cells.

5 d in biomedicine, biosensing or for building synthetic cells.

6 gineering advanced biomimetic agents such as synthetic cells.

7 s both structural and functional elements of synthetic cells.

8 tunable platform for programming release is synthetic cells.

9 ology, biosensing, targeted drug release, or synthetic cells.

10 lecular gates for drug delivery, or to build synthetic cells.

11 NA materials to mimic life-like functions in synthetic cells.

12 mplified pathways for membrane generation in synthetic cells.

13 lar transport in biosensing, sequencing, and synthetic cells.

14 , showing promise in building biosensors and synthetic cells.

15 on of functionalities in both biological and synthetic cells.

16 ent key early steps in the reconstitution of synthetic cells.

17 have utility in the construction of minimal synthetic cells.

18 nally, structurally and functionally complex synthetic cells.

19 as whole-cell models and the engineering of synthetic cells.

20 ally for use with biological logic gates and synthetic cells.

21 design principles for conferring motility to synthetic cells.

22 design, and the construction of minimal and synthetic cells.

23 neous again, with infrequent division of the synthetic cells.

24 sensing, drug delivery, and the creation of synthetic cells.

25 ssembly of new infectious virions within the synthetic cells.

26 res at the cortex or within the lumen of the synthetic cells.

27 esting, biophysical studies and their use as synthetic cells.

28 and opening up its use in the generation of synthetic cells.

29 romolecular machines, metabolic networks and synthetic cells.

30 l strategy towards the bottom-up assembly of synthetic cells.

31 trafast bioengineered systems such as active synthetic cells.

32 pid release of molecules encapsulated within synthetic cells.

33 esicles as a way to automate the assembly of synthetic cells.

34 membrane proteins, and provide a chassis for synthetic cells.

35 ly, structurally and morphologically complex synthetic cells.

36 e(3)O(4) nanoparticles and embedding them in synthetic cells.

37 So far, genetic regulation of synthetic cell activity has been largely confined to che

38 Here we show that a wide array of synthetic cell adhesion molecules can be generated by co

39 The modularity of synthetic cell adhesion molecules provides fundamental i

40 identity of the intracellular domain of the synthetic cell adhesion molecules specifies interface mo

41 Projects such as BaSyC (Building a Synthetic Cell) aim to build an entity that mimics how l

42 organize biochemical processes in cells and synthetic cell analogues.

43 , quorum-sensing-based communication between synthetic cells and bacteria was controlled with light.

44 ular communication mechanisms engineered for synthetic cells and classify them based on their resembl

45 ined fashion, with potential applications in synthetic cells and nanoreactors.

46 provide a platform to engineer functions of synthetic cells and protocells.

47 ould be exploited in the bottom-up design of synthetic cells and tissues, to the generation of smart

48 lucidate complex cellular mechanisms, create synthetic cells, and discover new therapeutics.

49 hemicals, constructing metabolic modules for synthetic cells, and even enabling molecular computation

50 crodroplets are finding increased utility in synthetic cell applications due to their cytomimetic pro

51 Bottom-up synthetic cells are as a platform for replicating and pr

52 rogress in this field, including areas where synthetic cells are having socioeconomic and technologic

53 ncement is key to unlocking the potential of synthetic cells as cell models and as microdevices in bi

54 ould unlock a wide range of applications for synthetic cells as programmable micromachines in biomedi

55 o build up genetic complexity in an evolving synthetic cell, as well as to study evolutionary process

56 We demonstrate that synthetic cells based on droplet-supported lipid bilayer

57 A synthetic cell-binding peptide (P-15) combined with anor

58 A synthetic cell-binding peptide (P-15) combined with anor

59 The role of a synthetic cell-binding peptide (P-15), combined with ano

60 ese results suggest that the use of the P-15 synthetic cell-binding peptide combined with ABM yields

61 ese results suggest that the use of the P-15 synthetic cell-binding peptide combined with ABM yields

62 erived hydroxyapatite matrix combined with a synthetic cell-binding peptide P-15 (Putty P15) to deter

63 ith a bovine-derived xenograft coated with a synthetic cell-binding peptide; then the test group rece

64 Our work provides a foundation for a synthetic cell biology in which multi-protein macroscale

65 Immunopharma) is a customizable, degradable synthetic cell biomimetic that emulates physiologic, cel

66 etic biology is to enhance the complexity of synthetic cells by establishing functional compartmental

67 Here, synthetic cells, called nanoreactors, are engineered for

68 Synthetic cells can be constructed from diverse molecula

69 Additionally, these synthetic cells can be efficiently removed from T cells

70 Encased in a lipid bilayer structure, synthetic cells can be outfitted with molecular conduits

71 An open question is whether simplified synthetic cells can gain similar complex functionality b

72 These findings demonstrate synthetic cells capable of autonomous circadian rhythms

73 Here we introduce a synthetic cell-cell adhesin logic with swarming bacteria

74 face patterns(2,9) is still very limited, as synthetic cell-cell adhesion toolkits and suitable patte

75 The construction of synthetic cell-cell communication networks can improve o

76 ave applications ranging from drug design to synthetic cell circuits.

77 sed cell-cell interactions inferred from the synthetic cells closely resemble the original data, achi

78 mic control over protein distribution within synthetic cells comprising a lipid bilayer membrane surr

79 The flexible and modular design of synthetic cells, comprising lipid vesicles capable of im

80 synthetic cell modules and augmented living/synthetic cell constructs with potential applications in

81 , we pave the way for the development of new synthetic cell constructs.

82 Synthetic cells containing genetic programs and protein

83 oluble Abeta oligomers from several sources (synthetic, cell culture, human brain extracts) facilitat

84 us work expressing membrane pore proteins in synthetic cells demonstrated content exchange, user-defi

85 ll-free protein expression and vesicle-based synthetic cell design to create cell-sized capsules able

86 ble tool for synthetic biology and bottom-up synthetic cell design.

87 agnetic field, which is absent from existing synthetic cell designs.

88 polymersomes are particularly attractive for synthetic cell development and drug delivery systems.

89 In the framework of artificial or synthetic cell development, giant liposomes are common b

90 plored, molecular crowding at the surface of synthetic cells emerges as an additional development wit

91 In the bioengineered world, advances in synthetic cell engineering and biorobotics have created

92 this study contributes to the development of synthetic cells, enhancing our understanding of the mini

93 cell-free viral cycle where T7 phages infect synthetic cells, equipped with lipopolysaccharides on th

94 olling a wide range of in vitro chemistries, synthetic cell-free biochemical circuits promise to be u

95 port here on the development of a completely synthetic cell-free therapy based on peptide amphiphile

96 (CV) protocol introduces an efficient, fully synthetic, cell-free approach for preparing gRNA express

97 lates, in situ gene expression and, thereby, synthetic cell function can be controlled according to s

98 So far, a fully synthetic cell has remained elusive, but chemists are pr

99 loped novel criteria for evaluating how well synthetic cell images reflect the properties of real ima

100 in phase-separated membrane domains of model synthetic cells, imitating the localization of multimeri

101 d present activated release of material from synthetic cells in a light-sensitive fashion.

102 ological conditions and their suitability as synthetic cells in biological media.

103 s associated with increased calcification of synthetic cells in response to high extracellular Ca(2+)

104 A relatively unexplored energy source in synthetic cells is transmembrane electron transport, whi

105 ith good spatial and temporal control within synthetic, cell-laden biomimetic scaffolds.

106 w available to generate rudimentary forms of synthetic cell-like entities, minimal progress has been

107 controlled drug release and the building of synthetic cell-like or logic ionic networks.

108 Larger assemblies of synthetic cells may be used to form prototissues.

109 Under irradiation, the synthetic cell membranes can interact with chemical buil

110 Combining these systems enables synthetic cell microreactors to be built using a nested

111 t microfluidic system for the fabrication of synthetic cells mimicking the viscoelastic and T-cell-ac

112 Here, we fabricate a synthetic cell-mimicking microparticle (CMMP) that recap

113 a simple method for the de novo creation of synthetic cell mimics in the form of giant polymeric ves

114 Here, we design and assemble a monolayer of synthetic cell-mimics and examine their collective behav

115 e-induced vasodilation by constructing a new synthetic cell model based on bio-derived coacervate ves

116 We screen a range of synthetic cell models for their ability to form augmente

117 Synthetic cell models help us understand living cells an

118 ent work and challenges in developing these "synthetic cell" models and their growing practical appli

119 ide opportunities for the fabrication of new synthetic cell modules and augmented living/synthetic ce

120 gineering synthetic cellular communities and synthetic cell-natural cell communication.

121 ulating blood sugar; and the construction of synthetic 'cells' or particles mimicking functional aspe

122 assive simulations of particles diffusing in synthetic cells parameterized by morphometric statistics

123 of complex biological pathways and use with synthetic cells, particularly using remote, nondamaging

124 Synthetic cell permeable C2-ceramide induced apoptotic d

125 in/TCF-dependent transcription, we developed synthetic cell-permeable analogs of beta-catenin's helix

126 ence of N-acetylsphingosine (C2-ceramide), a synthetic cell-permeable ceramide analog.

127 Synthetic cell-permeable ceramides (C6- and C2-ceramide)

128 ules that can be oligomerized in vivo by the synthetic cell-permeable dimerizer FK1012H2.

129 urthermore, treating BMECs with cavtratin, a synthetic cell-permeable peptide encoding the caveolin-1

130 3-methyl-but-2-enyl diphosphate (HMBPP) or a synthetic cell-permeable prodrug, bis (pivaloyloxymethyl

131 everal families of readily prepared, totally synthetic, cell-permeable dimerizers composed of ligands

132 s available, control of gene expression with synthetic, cell-permeable molecules is within reach.

133 nto IGCs, and addition of a newly developed, synthetic, cell-permeable P/CAF inhibitor blocks this mo

134 These findings demonstrate that a synthetic, cell-permeable small-molecule can be develope

135 Here we report the design of synthetic, cell-permeable, stabilized alpha-helical pept

136 inds and stabilizes the fluorescent state of synthetic cell permeant fluorogenic chromophores (so-cal

137 ication, dendritic MCM emerge as a promising synthetic cell platform for the selective delivery of th

138 eration T cell therapies by the induction of synthetic cell programmes.

139 ever, recent progress toward the creation of synthetic cells, ranging from simple protocells to artif

140 But what kind of entity would a synthetic cell really be?

141 The programmed construction of functional synthetic cells requires spatial control over arrays of

142 Routinizing the engineering of synthetic cells requires specifying beforehand how many

143 nimal reactive precursors is a major goal in synthetic cell research.

144 The remodeled light-responsive synthetic cells reversibly alter their shape under irrad

145 t would be valuable in synthetic biology and synthetic cell science.

146 ic biology has stimulated the development of synthetic cells (SCs), autonomous protein-manufacturing

147 ch sophisticated behaviors in liposome-based synthetic cells (SCs).

148 how the model may be deployed to design new synthetic cell signaling circuits based on a desired fin

149 Synthetic cells spark intriguing questions about the nat

150 nded to other applications in the context of synthetic cells such as transport, signaling, and contro

151 The resulting synthetic cells support robust T cell activation and exp

152 Synthetic cell surface receptors have potential applicat

153 nce of inter- and extracellular adhesion and synthetic cell surface tension are key material properti

154 emonstrate the first production of a totally synthetic cell-surface receptor for a virus.

155 Synthetic cells (SynCells) are artificial constructs des

156 Here, we describe a dynamic synthetic cell system assembled using artificial lipids

157 This method yields synthetic cells (tentatively neurons and astrocytes) tha

158 ort the development of temperature-sensitive synthetic cells that control protein production by explo

159 dergo phenotypic conversion to proliferative synthetic cells that generate extracellular matrix to fo

160 hetic biology have led to the development of synthetic cells that mimic some features of real cells,

161 computational models to generate in silico "synthetic" cells that faithfully mimic the temporal traj

162 To produce a synthetic cell, the genome must be transferred from yeas

163 The RNA condensates can be expressed within synthetic cells to produce membrane-less organelles with

164 Replicating cellular functions requires synthetic cells to remain structurally stable in biologi

165 rrent interest in mimicking this behavior in synthetic cells to understand the physical basis of inte

166 dels(2-6), can be used to efficiently design synthetic, cell-type-specific enhancers, starting from r

167 ied settings, engineering stimuli-responsive synthetic cells under genetic regulation is imperative.

168 way for customizable, genetically programmed synthetic cells under thermal control to be used in biot

169 selective transcriptional activation inside synthetic cells, underscoring the potential of Chol-ssDN

170 control the synthesis of biomolecules within synthetic cells using a tissue-penetrating stimulus open

171 sed mechanism for transmembrane signaling in synthetic cells using cholesterol-modified single-strand

172 ngs us closer to the bottom-up generation of synthetic cells using recombinant synthetic biology plat

173 A synthetic cell-wall analogue was developed to hijack the

174 structures of the enzyme in complex with two synthetic cell-wall-based ligands, we present for the fi

175 e catalytic domain of LytA in complex with a synthetic cell-wall-based peptidoglycan (PG) ligand that

176 n the design of bacteria with non-canonical "synthetic" cell walls.

177 ng the genetic code converged when the first synthetic cell was created 4 years ago.

178 his work, cell-free protein synthesis within synthetic cells was controlled using light by encoding g

179 The origin of synthetic cells was further examined by colocalization o

180 g these orthogonal light-activated DNAs into synthetic cells, we used two overlapping patterns of blu

181 In this way, synthetic cells were activated remotely, in a spatiotemp

182 increases in the maximum growth rate of the synthetic cells were comparable.

183 ntinuous development of bottom-up engineered synthetic cells, which have become increasingly similar

184 formidable task to construct a true-to-life synthetic cell with high organizational and functional c

185 bottleneck exists preventing the creation of synthetic cells with a defined nucleus-like compartment

186 illustrate an approach for the evolution of synthetic cells with alternative biochemical building bl

187 The protocol includes fabrication of synthetic cells with defined sizes, crosslinking strateg

188 Here, we present an approach for creating synthetic cells with distinct nucleus-like compartments

189 We envisage that interfacing synthetic cells with engineered, multifunctional DNA nan

190 lved in designing, manipulating and creating synthetic cells with hierarchical organization and funct

191 re a versatile platform for creating minimal synthetic cells with life-like functions.

192 re novel approaches towards the formation of synthetic cells with rigid shells, additive manufacturin