ライフサイエンスコーパス: synthetic compound

1 AFs accumulation in stored maize, replacing synthetic compounds.

2 , validated, and used to screen a library of synthetic compounds.

3 ably with experimental results found for the synthetic compounds.

4 on in response to a diversity of natural and synthetic compounds.

5 metabolites, signaling molecules, and other synthetic compounds.

6 have been reported of SF-1 in complexes with synthetic compounds.

7 ntibiotic drugs and even diverse natural and synthetic compounds.

8 herry-picked from all commercially available synthetic compounds.

9 ne the allosteric regulation of myosins with synthetic compounds.

10 fied by screening our in-house collection of synthetic compounds.

11 ermine the absolution configurations of such synthetic compounds.

12 resent in a broad range of other natural and synthetic compounds.

13 of the substrates used to assay cytGSTs are synthetic compounds.

14 ely used building blocks in both natural and synthetic compounds.

15 , mandelalides E-L (5-12), and the supply of synthetic compounds 1 and 12, as well as seco-mandelalid

16 thocholic acid, oleanolic acid [OA], and two synthetic compounds), (2) a novel TGR5 antagonist (m-tol

17 Here we describe a synthetic compound, 2-fluoro-1-methoxy-4-pentafluorophen

18 ram around an identified hit resulted in new synthetic compound 26 [UCM-1306, 2-(fluoromethoxy)-4'-(S

19 We report that EF24, a synthetic compound 3,5-bis(2-flurobenzylidene)piperidin-

20 By contrast, a synthetic compound, 3-(1H-imidazol-1-ylmethyl)-2phenyl-1

21 y for new anticancer agents and identified a synthetic compound, 5-(2,4-dihydroxybenzylidene)-2-(phen

22 te MAIT cells but compete with bacterial and synthetic compounds activating MAIT cells, providing the

23 rived natural product, ikarugamycin; and the synthetic compound, alexidine dihydrochloride, which is

24 Retinoic acid and its synthetic compound AM80 play roles in immunoregulation b

25 s) of the various cytokines showed that each synthetic compound and E. coli 055:B5 LPS induced simila

26 this simple infection system to screen 6,000 synthetic compounds and 1,136 natural product extracts.

27 When placed in field traps, the synthetic compounds and a queen-equivalent mixture rapid

28 harma industry uses, as replacements for the synthetic compounds and also in the valorisation of plan

29 of biologically active natural products and synthetic compounds and can be accessed using mild react

30 he evolution of MGs from natural products to synthetic compounds and discuss integration of emerging

31 particular molecular properties compared to synthetic compounds and drugs.

32 Mouse macrophages were exposed to the synthetic compounds and E. coli 055:B5 LPS, and the resu

33 These modulators include both synthetic compounds and endogenous modulators, such as c

34 date this technique, we prepared mixtures of synthetic compounds and extracts from Arabidopsis thalia

35 and female D. suzukii olfactory responses to synthetic compounds and fruit juices as sources of attra

36 Biological evaluation of the synthetic compounds and intermediates against a panel of

37 ntiate distributions of natural products and synthetic compounds and is applicable in the analysis of

38 creening of substantially greater numbers of synthetic compounds and natural products, we are not rou

39 were compared with several other natural and synthetic compounds and related to glutathione and ascor

40 Phthalates are ubiquitous synthetic compounds and therefore difficult to measure i

41 SHU9119 (a synthetic compound) and AGRP (an endogenous peptide) are

42 al scaffolds encountered in both natural and synthetic compounds, and their biological activity often

43 The physical properties of the synthetic compound are somewhat different from those rep

44 m this laboratory indicates that a number of synthetic compounds are high affinity transport inhibito

45 Biomolecules and high-value synthetic compounds are rarely isotropic, highly-symmetr

46 in numerous biologically active natural and synthetic compounds, are efficiently prepared by a Rh(I)

47 In this study, we aimed to develop a small synthetic compound as a UL141 antagonist.

48 re, we examined the ability of TFA-12, a new synthetic compound belonging to tocopherol long-chain fa

49 and designed DNA fragments indicate that the synthetic compounds bind at AT sequences in the minor gr

50 We have shown previously that EM011, a synthetic compound, binds tubulin with a higher affinity

51 the sigma-1 receptor binds a vast number of synthetic compounds but does not bind opioid peptides; i

52 The replacement of synthetic compounds by essential oils for inhibition of

53 d synthase (FAS) inhibitors (cerulenin and a synthetic compound C75) led to inhibition of feeding and

54 the natural product cerulenin and the novel synthetic compound c75, are selective inhibitors of tumo

55 However, some synthetic compounds can fall outside the upper boundary

56 We have found that the synthetic compound CC-5079 potently inhibits cancer cell

57 sense a broad spectrum of ligands, including synthetic compounds, chemokines, mitogens, fatty acids,

58 gineered G-protein coupled receptor with the synthetic compound clozapine-N-oxide (CNO) evoked a shor

59 These synthetic compounds contain sequences that are active si

60 The synthetic compounds contained pentyl, hexyl, or hexanoyl

61 t a substantial fraction (~20%) of cytotoxic synthetic compounds containing Michael acceptor groups i

62 on of 7 and 8 along with several related key synthetic compounds containing the core residue 4 amidin

63 Nine structurally related synthetic compounds, containing aromatic or other hydrop

64 d MS/MS fragmentation pattern and, using the synthetic compound, demonstrate that it has bioactivity.

65 PM534 is a novel synthetic compound derived from the Structure-Activity-R

66 A synthetic compound designed to bind in this pocket, and

67 ZIP is a synthetic compound designed to inhibit the atypical PKC,

68 ychoactive substances (NPSs) which are small synthetic compounds designed to mimic the effects of oth

69 The NMR data of the synthetic compound did not conform to the reported natur

70 In each assay, the synthetic compounds displayed comparable activity to the

71 actions could be efficiently disrupted using synthetic compounds either mimicking or masking this car

72 A racemic blend of the synthetic compound elicited behavioral and electrophysio

73 mer therefore represents an innovative fully synthetic compound for the treatment of lung inflammator

74 was proposed for use in screening natural or synthetic compounds for cell cycle-dependent (particular

75 ing of a 50000-member library of natural and synthetic compounds for sensitizers of RCC cells to TRAI

76 tionship (QSAR) of a group of endogenous and synthetic compounds for the androgen receptor (AR) using

77 talline materials has prompted the design of synthetic compounds for the regulation of crystal growth

78 Evaluation of the synthetic compounds for their ability to act as microbe-

79 hroughput whole-cell-based screening of 5000 synthetic compounds from the AnalytiCon NATx library hel

80 In addition, a number of synthetic compounds have been developed that also target

81 Many categories of both natural and synthetic compounds have been reported to have neuroprot

82 A number of synthetic compounds have been shown to block the process

83 way-specific screens of natural products and synthetic compounds have recently provided a number of s

84 The new synthetic compounds have two aromatic-amidine groups for

85 ystem for throughput screening of natural or synthetic compounds highly effective on blocking of PRRS

86 We herein report the first examples of synthetic compound-I and activated compound-II species t

87 Carba-NAD is a synthetic compound identical to NAD except for one subst

88 The synthetic compounds identified in these assays should se

89 me may have evolved the ability to hydrolyze synthetic compounds in bacteria under selective pressure

90 the mechanism of stimulation mediated by the synthetic compounds in comparison with natural lipoprote

91 here the efficacies of several of these new synthetic compounds in regulating two types of protein d

92 ar activities remain unexplored, and diverse synthetic compounds including insecticides exert JH-like

93 unctional analyses using highly purified and synthetic compounds indicate that the core structure rec

94 , and further examination revealed that this synthetic compound induced expression of an AP-1 target

95 nrelated small-molecule natural products and synthetic compounds inhibit Sec61 with differential effe

96 The synthetic compound ink derived from the dissolution of t

97 Novel AIT preparations, such as synthetic compounds, innovative carrier systems and adju

98 aromatic substances when the amount of added synthetic compound is in tens of percent.

99 Remediation of these synthetic compounds is difficult and an enormous logisti

100 A series of chiral synthetic compounds is reported that shows intricate but

101 SU5416, a novel synthetic compound, is a potent and selective inhibitor

102 PPARs are the targets for the hypolipidemic synthetic compounds known as peroxisome proliferators, a

103 ocessing of compound lesions by human cells, synthetic compound lesions containing UV photoproducts o

104 tration barrier makes screening conventional synthetic compound libraries largely impractical, and ac

105 search for inhibitors in natural product and synthetic compound libraries.

106 ural products for drug discovery in favor of synthetic compound libraries.

107 These synthetic compounds made it possible to establish relati

108 gands include a diverse array of natural and synthetic compounds, many of which are toxins.

109 The synthetic compounds matched the physical and biological

110 These synthetic compounds model peptide-nucleic acid heterocon

111 Our synthetic compounds modulated significantly both platele

112 In this report, we describe a synthetic compound of the pyrido[2,3-d]pyrimidine class,

113 oiety found in a large number of natural and synthetic compounds of medicinal significance.

114 l groups comprise a large set of natural and synthetic compounds, often with potent biological activi

115 These agents are synthetic compounds or natural products and their analog

116 Retinoids are a large family of natural and synthetic compounds related to vitamin A that have pleio

117 A referenced tabulation of the synthetic compounds reported to date is provided.

118 The degradation of synthetic compounds requires bacteria to recruit and ada

119 Analysis of synthetic compounds revealed stereoselectivity of the DA

120 , as well as the use of purified natural and synthetic compounds, showed that this process involved p

121 f the family of flavones and isoflavones and synthetic compounds such as the tyrphostins.

122 , and erysolin) and one of which was a novel synthetic compound termed MARPIN.

123 osophila suzukii to foliage- and fruit-based synthetic compounds tested alone and in association with

124 vated receptor (PPAR) gamma, we identified a synthetic compound that binds to this receptor.

125 or an estradiol-dendrimer conjugate, each a synthetic compound that stimulates kinase-mediated ER ac

126 e-disrupting chemicals (EDCs) are natural or synthetic compounds that are ubiquitous in the environme

127 Perfluoroalkyl substances (PFASs) are synthetic compounds that are widely used in industry and

128 and exciting target for the design of novel synthetic compounds that can act as anti-proliferative a

129 We have identified two classes of synthetic compounds that differentially modulate BAR act

130 s a key skeletal unit in several natural and synthetic compounds that exhibit diverse biological prop

131 Here we describe novel synthetic compounds that have a unique mode of binding t

132 Lack of efficient access to collections of synthetic compounds that have skeletal diversity is a ke

133 be discovered using a diverse collection of synthetic compounds that have three-dimensional features

134 r screening process was designed to identify synthetic compounds that increase the total amount of fu

135 racterization of transcriptional regulators, synthetic compounds that inhibit transcription, or other

136 A key feature found in synthetic compounds that is rare in nature is the use of

137 fact, the serum of mice immunized with fully synthetic compounds that mimic cell-surface tumour antig

138 Xenoestrogens are synthetic compounds that mimic endogenous estrogens by b

139 cidations, and rationally designed bioactive synthetic compounds that were accomplished because of co

140 Amino acid-derived isoindolines are synthetic compounds that were created with the idea of i

141 The assays use synthetic compounds that were designed to mimic the natu

142 ttention was drawn to certain, predominantly synthetic, compounds that are responsible for disproport

143 Despite the prevalence of fluorine in synthetic compounds, the known biological scope is limit

144 c agents, and it is the first non-polyamide, synthetic compound to specifically recognize a DNA seque

145 interactions involved in the binding of this synthetic compound to the 80S ribosome.

146 he receptor are inferred from the ability of synthetic compounds to affect channel function without i

147 hepatocytes and are among the first totally synthetic compounds to approach the activity of adenopho

148 n difficult, in part due to the tendency for synthetic compounds to bind unpredictably within the lip

149 The work reported here uses synthetic compounds to evaluate the extent of NN weakeni

150 Application of synthetic compounds to inhibit potato sprouting is a maj

151 xidants can be used in egg powder instead of synthetic compounds to reduce malonaldehyde production d

152 The ability of natural and synthetic compounds to stimulate transforming growth fac

153 Many synthetic compounds to which we attribute specific activ

154 mimicked reproductive cheaters by applying a synthetic compound typical of fertile individuals on non

155 e methyl siloxanes (VMS) are high-production synthetic compounds, ubiquitously found in the environme

156 h-throughput screen of approximately 200,000 synthetic compounds using Per2lucSV reporter fibroblast

157 natural products, drugs, cosmetics and other synthetic compounds) using a limited number of pre-defin

158 Each synthetic compound was reacted under anaerobic condition

159 Proton, (13)C NMR, and molecular mass of the synthetic compound were identical with vesperlysine A, a

160 The synthetic compounds were employed to uncover immunodomin

161 The synthetic compounds were evaluated for antibacterial act

162 The synthetic compounds were evaluated for in vitro antivira

163 a significant portion of biologically active synthetic compounds were found to be pseudo-natural prod

164 Indeed, all synthetic compounds were found to bind to the target RNA

165 The synthetic compounds were used to examine binding propert

166 Structures of the synthetic compounds were verified by NMR spectroscopy us

167 The drug is a totally synthetic compound, which lessens the likelihood of natu

168 ening of a chemical library, we identified a synthetic compound whose inducing ability significantly

169 r- and polyfluoroalkyl substances (PFAS) are synthetic compounds widely employed in society due to th

170 Imiquimod is a synthetic compound with antitumor properties; a 5% cream

171 this study, we employed virtual screening of synthetic compounds with a natural product scaffold in c

172 Naphthoquinones (NQs) are natural and synthetic compounds with a wide range of biological acti

173 Hence, screening and identifying natural or synthetic compounds with anti-cancer activity via p53-in

174 represent a class of naturally occurring and synthetic compounds with demonstrated antitumor activity

175 f normal reproductive functions, natural and synthetic compounds with estrogen-like activities can fu

176 luoroalkyl substances (PFAS) are over 14 000 synthetic compounds with exceptional environmental persi

177 target and to inform the development of new synthetic compounds with improved potency and reduced cy

178 Simple synthetic compounds with only S and C donors offer a lig

179 us antioxidant mechanisms and neutralized by synthetic compounds with peroxynitrite-scavenging capaci

180 occur as constituents of various natural and synthetic compounds with potentially useful bioactivitie

181 f cell migration data for this and two other synthetic compounds with published data on cortistatin A

182 In this case, the evaluation of just six synthetic compounds with seven riboswitch mutants led to

183 th the NMR data and specific rotation of the synthetic compounds with that of the reported data.

184 Furthermore, analyses of four of the synthetic compounds with two important purified resistan

185 of nucleic acid libraries into corresponding synthetic compounds would enable selection and amplifica

186 ion of cytochromes P4501A1/2 (CYP1A1/2) by a synthetic compound YH439 was studied in rodents as well